Search of human proteins with 27597078

Search of human proteins with 27597078

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27597078 TYRO3 protein tyrosine kinase [Homo sapiens]
         (890 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27597078 TYRO3 protein tyrosine kinase [Homo sapiens]             1803   0.0  
gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]     677   0.0  
gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]     676   0.0  
gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]     627   e-179
gi|42741655 met proto-oncogene isoform b precursor [Homo sapiens]     232   1e-60
gi|188595716 met proto-oncogene isoform a precursor [Homo sapiens]    232   1e-60
gi|153946393 macrophage stimulating 1 receptor precursor [Homo s...   228   2e-59
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo...   222   1e-57
gi|119395738 insulin receptor isoform Short precursor [Homo sapi...   218   2e-56
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]   218   2e-56
gi|221316650 ephrin receptor EphA1 [Homo sapiens]                     216   8e-56
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like...   214   4e-55
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]   213   5e-55
gi|10862701 ret proto-oncogene isoform c [Homo sapiens]               210   4e-54
gi|10862703 ret proto-oncogene isoform a [Homo sapiens]               210   4e-54
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...   209   9e-54
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...   209   9e-54
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]    205   1e-52
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap...   203   5e-52
gi|31657140 insulin receptor-related receptor precursor [Homo sa...   203   7e-52
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]   202   1e-51
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]   202   1e-51
gi|17975768 ephrin receptor EphB3 precursor [Homo sapiens]            202   1e-51
gi|29029632 anaplastic lymphoma kinase [Homo sapiens]                 201   3e-51
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]             200   6e-51
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]               200   6e-51
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]             200   6e-51
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]             200   6e-51
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]             200   6e-51
gi|54607018 RYK receptor-like tyrosine kinase isoform 2 [Homo sa...   196   1e-49

>gi|27597078 TYRO3 protein tyrosine kinase [Homo sapiens]
          Length = 890

 Score = 1803 bits (4671), Expect = 0.0
 Identities = 890/890 (100%), Positives = 890/890 (100%)

Query: 1   MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPV 60
           MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPV
Sbjct: 1   MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPV 60

Query: 61  KLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVE 120
           KLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVE
Sbjct: 61  KLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVE 120

Query: 121 DGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKI 180
           DGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKI
Sbjct: 121 DGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKI 180

Query: 181 GGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSN 240
           GGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSN
Sbjct: 181 GGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSN 240

Query: 241 ASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRC 300
           ASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRC
Sbjct: 241 ASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRC 300

Query: 301 ANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKL 360
           ANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKL
Sbjct: 301 ANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKL 360

Query: 361 SWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQ 420
           SWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQ
Sbjct: 361 SWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQ 420

Query: 421 GPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAA 480
           GPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAA
Sbjct: 421 GPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAA 480

Query: 481 RSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQE 540
           RSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQE
Sbjct: 481 RSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQE 540

Query: 541 DGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPM 600
           DGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPM
Sbjct: 541 DGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPM 600

Query: 601 VILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARN 660
           VILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARN
Sbjct: 601 VILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARN 660

Query: 661 CMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGV 720
           CMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGV
Sbjct: 661 CMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGV 720

Query: 721 TMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFT 780
           TMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFT
Sbjct: 721 TMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFT 780

Query: 781 CLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAV 840
           CLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAV
Sbjct: 781 CLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAV 840

Query: 841 GGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC 890
           GGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
Sbjct: 841 GGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC 890


>gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]
          Length = 885

 Score =  677 bits (1746), Expect = 0.0
 Identities = 379/874 (43%), Positives = 522/874 (59%), Gaps = 59/874 (6%)

Query: 21  PRLG-------LLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGM-EEP 72
           PR+G       L L   A +    + A     +G P  +T ++G    L C ++   E P
Sbjct: 6   PRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPP 65

Query: 73  DIQWVKDGAVVQNLD--QLYIPVSEQH---WI--GFLSLKSVERSDAGRYWCQVEDGGET 125
           ++ W++DG +++  D  Q  +P+ E     WI    L + S++ SD G+Y C V  G +T
Sbjct: 66  EVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQT 125

Query: 126 EISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIG---G 182
            +SQP ++ +EG+P+F  EP+D  V  N PF LSC+A GPPEPV ++W +    +    G
Sbjct: 126 FVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPG 185

Query: 183 PAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNAS 242
             P  S L+V G+ +++ FSCEAHN KG+ +SRTAT+ +  LP  P N+ +     +   
Sbjct: 186 HGPQRS-LHVPGLNKTSSFSCEAHNAKGVTTSRTATITV--LPQQPRNLHLVSRQPTELE 242

Query: 243 VAWMPGADGRALLQSCTVQVTQAPGGW-----------EVLAVVVPVPPFTCLLRDLVPA 291
           VAW PG  G   L  CT+Q   +  G            E L     VPP    L  L P 
Sbjct: 243 VAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPH 302

Query: 292 TNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPL 351
           T Y +RV C ++ GPS +  W+P +T    P   P+N+ A R  S   + W+E  P APL
Sbjct: 303 TPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQE--PRAPL 360

Query: 352 EGPLGPYKLSW--------VQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCG 403
           +G L  Y+L++        + D G + E+T+E     L G     +L V V    A G G
Sbjct: 361 QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLE-----LQGDGSVSNLTVCVAAYTAAGDG 415

Query: 404 PWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQA 463
           PWS P+ + +     +   P     W  V+LG + A      LAL L+ +R+KETR+G+ 
Sbjct: 416 PWSLPVPLEAWRPVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEV 475

Query: 464 FDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRM 523
           F+  + RGE  V +R  +S++R   E   ATL+SLGIS+ELKEKL DV++   +  LG+ 
Sbjct: 476 FEPTVERGELVVRYRVRKSYSRRTTE---ATLNSLGISEELKEKLRDVMVDRHKVALGKT 532

Query: 524 LGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKL 583
           LG+GEFG+V E QL Q+D S +KVAVK +K  I   S++E+FL EA CMKEFDHP+V +L
Sbjct: 533 LGEGEFGAVMEGQLNQDD-SILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL 591

Query: 584 VGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGM 643
           +GV  +   +   P P+VILPFMKHGDLH+FLL SR+G+ P  LP Q L++FM DIA GM
Sbjct: 592 IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM 651

Query: 644 EYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALES 703
           EYLS++ FIHRDLAARNCML E+M+VCVADFGLS+KIY+GDYYRQG  +K+PVKW+A+ES
Sbjct: 652 EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES 711

Query: 704 LADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYD 763
           LAD +YT +SDVW+FGVTMWEI TRGQTPY G+EN+EIY+YL  GNRLKQP +C++ +Y 
Sbjct: 712 LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA 771

Query: 764 LMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERA----EEPTAGGSL 819
           LM +CW  +P+ RPSFT LR +LEN L  L       + LY+N++      E P A G  
Sbjct: 772 LMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA 831

Query: 820 ELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTP 853
           + P +  P       S + A    P+  RY+L P
Sbjct: 832 DPPTQPDPKDSC---SCLTAAEVHPAG-RYVLCP 861


>gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]
          Length = 894

 Score =  676 bits (1743), Expect = 0.0
 Identities = 383/884 (43%), Positives = 525/884 (59%), Gaps = 70/884 (7%)

Query: 21  PRLG-------LLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGM-EEP 72
           PR+G       L L   A +    + A     +G P  +T ++G    L C ++   E P
Sbjct: 6   PRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPP 65

Query: 73  DIQWVKDGAVVQNLD--QLYIPVSEQH---WI--GFLSLKSVERSDAGRYWCQVEDGGET 125
           ++ W++DG +++  D  Q  +P+ E     WI    L + S++ SD G+Y C V  G +T
Sbjct: 66  EVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQT 125

Query: 126 EISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIG---G 182
            +SQP ++ +EG+P+F  EP+D  V  N PF LSC+A GPPEPV ++W +    +    G
Sbjct: 126 FVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPG 185

Query: 183 PAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNAS 242
             P  S L+V G+ +++ FSCEAHN KG+ +SRTAT+ +  LP  P N+ +     +   
Sbjct: 186 HGPQRS-LHVPGLNKTSSFSCEAHNAKGVTTSRTATITV--LPQQPRNLHLVSRQPTELE 242

Query: 243 VAWMPGADGRALLQSCTVQVTQAPGGW-----------EVLAVVVPVPPFTCLLRDLVPA 291
           VAW PG  G   L  CT+Q   +  G            E L     VPP    L  L P 
Sbjct: 243 VAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPH 302

Query: 292 TNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPL 351
           T Y +RV C ++ GPS +  W+P +T    P   P+N+ A R  S   + W+E  P APL
Sbjct: 303 TPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQE--PRAPL 360

Query: 352 EGPLGPYKLSW--------VQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCG 403
           +G L  Y+L++        + D G + E+T+E     L G     +L V V    A G G
Sbjct: 361 QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLE-----LQGDGSVSNLTVCVAAYTAAGDG 415

Query: 404 PWSQPLVVSSHDRAGQQGPPHSRTS----------WVPVVLGVLTALVTAAALALILLRK 453
           PWS P+ + +  R GQ  P H              W  V+LG + A      LAL L+ +
Sbjct: 416 PWSLPVPLEAW-RPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHR 474

Query: 454 RRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLI 513
           R+KETR+G+ F+  + RGE  V +R  +S++R   E   ATL+SLGIS+ELKEKL DV++
Sbjct: 475 RKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTE---ATLNSLGISEELKEKLRDVMV 531

Query: 514 PEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMK 573
              +  LG+ LG+GEFG+V E QL Q+D S +KVAVK +K  I   S++E+FL EA CMK
Sbjct: 532 DRHKVALGKTLGEGEFGAVMEGQLNQDD-SILKVAVKTMKIAICTRSELEDFLSEAVCMK 590

Query: 574 EFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLI 633
           EFDHP+V +L+GV  +   +   P P+VILPFMKHGDLH+FLL SR+G+ P  LP Q L+
Sbjct: 591 EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLV 650

Query: 634 RFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASK 693
           +FM DIA GMEYLS++ FIHRDLAARNCML E+M+VCVADFGLS+KIY+GDYYRQG  +K
Sbjct: 651 KFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAK 710

Query: 694 LPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQ 753
           +PVKW+A+ESLAD +YT +SDVW+FGVTMWEI TRGQTPY G+EN+EIY+YL  GNRLKQ
Sbjct: 711 MPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQ 770

Query: 754 PPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERA--- 810
           P +C++ +Y LM +CW  +P+ RPSFT LR +LEN L  L       + LY+N++     
Sbjct: 771 PADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGY 830

Query: 811 -EEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTP 853
            E P A G  + P +  P       S + A    P+  RY+L P
Sbjct: 831 PEPPGAAGGADPPTQPDPKDSC---SCLTAAEVHPAG-RYVLCP 870


>gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]
          Length = 999

 Score =  627 bits (1617), Expect = e-179
 Identities = 345/797 (43%), Positives = 492/797 (61%), Gaps = 33/797 (4%)

Query: 52  LTVSQGQPVKLNCSVEG---MEEPDIQWVKDGAVVQN----LDQLYIPVSEQHWIGFLSL 104
           + +S+ + VK NCS+      ++  I W KDG  +      + Q Y        I   S+
Sbjct: 103 IILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSI 162

Query: 105 KSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVG 164
            SV+RSD G Y C+++   E  +S P+++ V+G+P FT +P+ + V  N  F L+C+AVG
Sbjct: 163 TSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVG 222

Query: 165 PPEPVTIVWWRGTTKIGG-PAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQA 223
           PPEPV I W + ++++   P  SPSVL V G+T+  +FSCEAHN KGL  S+   ++++A
Sbjct: 223 PPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKA 282

Query: 224 LPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAP--GGWEVLAVVVPVPPF 281
           +P+ P  +++   ++ +  ++W+PG DG +  ++C++QV +A       V+       P 
Sbjct: 283 IPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPH 342

Query: 282 TCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSG--LI 339
              ++ L    NYS+ V C N +G S  + W+   T   AP+ AP N+     +S   + 
Sbjct: 343 LYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVD 402

Query: 340 LEWEEVIPEAPLEGPLGPYKLSWV-QDNGTQDELTVE----GTRANLTGWDPQKDLIVRV 394
           + W +  P    +G L  Y++S V Q  G   EL  E    G+RA ++         VR+
Sbjct: 403 IRWMKP-PTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRI 461

Query: 395 CVSNAVGCGPWSQP--LVVSSH---DRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALI 449
                 G GP+S P  + + +H   D A    P       V ++ G     +    +  I
Sbjct: 462 AAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYI 521

Query: 450 LL--RKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEK 507
            L  RKR +ET+FG AF       E  V++ A +SF R     IE TL SLG+S+EL+ K
Sbjct: 522 SLAIRKRVQETKFGNAFTE--EDSELVVNYIAKKSFCRRA---IELTLHSLGVSEELQNK 576

Query: 508 LEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLR 567
           LEDV+I      LG++LG+GEFGSV E  LKQEDG+ +KVAVK +K D  +  +IEEFL 
Sbjct: 577 LEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLS 636

Query: 568 EAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNL 627
           EAACMK+F HP+V +L+GV +   ++G +P PMVILPFMK+GDLH +LL SR+   P ++
Sbjct: 637 EAACMKDFSHPNVIRLLGVCIEMSSQG-IPKPMVILPFMKYGDLHTYLLYSRLETGPKHI 695

Query: 628 PLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYR 687
           PLQTL++FMVDIA GMEYLS+RNF+HRDLAARNCML +DMTVCVADFGLS+KIYSGDYYR
Sbjct: 696 PLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYR 755

Query: 688 QGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIG 747
           QG  +K+PVKW+A+ESLAD +YT +SDVWAFGVTMWEI TRG TPY G++N E+Y+YL+ 
Sbjct: 756 QGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLH 815

Query: 748 GNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINI 807
           G+RLKQP +C++++Y++MY CW  DP  RP+F+ LR++LE +L  L  +    D +Y+N 
Sbjct: 816 GHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNT 875

Query: 808 ERAE--EPTAGGSLELP 822
           +  E  E  A GS   P
Sbjct: 876 QLLESSEGLAQGSTLAP 892


>gi|42741655 met proto-oncogene isoform b precursor [Homo sapiens]
          Length = 1390

 Score =  232 bits (591), Expect = 1e-60
 Identities = 123/290 (42%), Positives = 173/290 (59%), Gaps = 15/290 (5%)

Query: 495  LDSLGISDELKEKLEDVLIPEQQFTL--GRMLGKGEFGSVREAQLKQEDGSFVKVAVKML 552
            +D   ++ EL + ++ V+I      +    ++G+G FG V    L   DG  +  AVK L
Sbjct: 1053 IDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSL 1112

Query: 553  KADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLH 612
               I    ++ +FL E   MK+F HP+V  L+G+ LRS        P+V+LP+MKHGDL 
Sbjct: 1113 NR-ITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGS-----PLVVLPYMKHGDLR 1166

Query: 613  AFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVA 672
             F     I     N  ++ LI F + +A GM+YL+S+ F+HRDLAARNCML E  TV VA
Sbjct: 1167 NF-----IRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVA 1221

Query: 673  DFGLSRKIYSGDYY--RQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQ 730
            DFGL+R +Y  +YY       +KLPVKW+ALESL    +T +SDVW+FGV +WE+MTRG 
Sbjct: 1222 DFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGA 1281

Query: 731  TPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFT 780
             PY  +   +I  YL+ G RL QP  C + +Y++M +CW    + RPSF+
Sbjct: 1282 PPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFS 1331


>gi|188595716 met proto-oncogene isoform a precursor [Homo sapiens]
          Length = 1408

 Score =  232 bits (591), Expect = 1e-60
 Identities = 123/290 (42%), Positives = 173/290 (59%), Gaps = 15/290 (5%)

Query: 495  LDSLGISDELKEKLEDVLIPEQQFTL--GRMLGKGEFGSVREAQLKQEDGSFVKVAVKML 552
            +D   ++ EL + ++ V+I      +    ++G+G FG V    L   DG  +  AVK L
Sbjct: 1071 IDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSL 1130

Query: 553  KADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLH 612
               I    ++ +FL E   MK+F HP+V  L+G+ LRS        P+V+LP+MKHGDL 
Sbjct: 1131 NR-ITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGS-----PLVVLPYMKHGDLR 1184

Query: 613  AFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVA 672
             F     I     N  ++ LI F + +A GM+YL+S+ F+HRDLAARNCML E  TV VA
Sbjct: 1185 NF-----IRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVA 1239

Query: 673  DFGLSRKIYSGDYY--RQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQ 730
            DFGL+R +Y  +YY       +KLPVKW+ALESL    +T +SDVW+FGV +WE+MTRG 
Sbjct: 1240 DFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGA 1299

Query: 731  TPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFT 780
             PY  +   +I  YL+ G RL QP  C + +Y++M +CW    + RPSF+
Sbjct: 1300 PPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFS 1349


>gi|153946393 macrophage stimulating 1 receptor precursor [Homo
            sapiens]
          Length = 1400

 Score =  228 bits (580), Expect = 2e-59
 Identities = 125/298 (41%), Positives = 181/298 (60%), Gaps = 15/298 (5%)

Query: 500  ISDELKEKLEDVLIPEQQFTL--GRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADII 557
            +   L  +++DVLIP ++      R++GKG FG V   +   +  + ++ A+K L   I 
Sbjct: 1062 LDSALLAEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSR-IT 1120

Query: 558  ASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLA 617
                +E FLRE   M+  +HP+V  L+G+ L         +P V+LP+M HGDL  F+ +
Sbjct: 1121 EMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEG-----LPHVLLPYMCHGDLLQFIRS 1175

Query: 618  SRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLS 677
             +   NP    ++ LI F + +A GMEYL+ + F+HRDLAARNCML E  TV VADFGL+
Sbjct: 1176 PQ--RNP---TVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLA 1230

Query: 678  RKIYSGDYY--RQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAG 735
            R I   +YY  +Q   ++LPVKW+ALESL    +T +SDVW+FGV +WE++TRG  PY  
Sbjct: 1231 RDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRH 1290

Query: 736  IENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQL 793
            I+  ++ ++L  G RL QP  C + +Y +M QCW ADP  RP+F  L  E+E I+  L
Sbjct: 1291 IDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSAL 1348


>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
            sapiens]
          Length = 1367

 Score =  222 bits (566), Expect = 1e-57
 Identities = 163/536 (30%), Positives = 264/536 (49%), Gaps = 72/536 (13%)

Query: 333  RTDSGLILEWEEVIPEAPLEGPLGPYKLSW---VQDN----GTQDELTVEGTRANLTGWD 385
            R ++ + L+W E  PE P  G +  Y++ +   V+D       Q+     G + N     
Sbjct: 843  RPENSIFLKWPE--PENP-NGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLN-- 897

Query: 386  PQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAA 445
               +   R+  ++  G G W+ P+      + G +   H   +    VL ++  LV    
Sbjct: 898  -PGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLV---- 952

Query: 446  LALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELK 505
            + L +  ++R  +R G   + V+       +F AA  +                + DE +
Sbjct: 953  IMLYVFHRKRNNSRLG---NGVLYASVNPEYFSAADVY----------------VPDEWE 993

Query: 506  EKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQ--EDGSFVKVAVKMLKADIIASSDIE 563
                   +  ++ T+ R LG+G FG V E   K   +D    +VA+K +  +  +  +  
Sbjct: 994  -------VAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN-EAASMRERI 1045

Query: 564  EFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASR--IG 621
            EFL EA+ MKEF+  HV +L+GV  + +        +VI+  M  GDL ++L + R  + 
Sbjct: 1046 EFLNEASVMKEFNCHHVVRLLGVVSQGQPT------LVIMELMTRGDLKSYLRSLRPEME 1099

Query: 622  ENPFNLP--LQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRK 679
             NP   P  L  +I+   +IA GM YL++  F+HRDLAARNCM+AED TV + DFG++R 
Sbjct: 1100 NNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRD 1159

Query: 680  IYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENA 739
            IY  DYYR+G    LPV+W++ ESL D ++T  SDVW+FGV +WEI T  + PY G+ N 
Sbjct: 1160 IYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNE 1219

Query: 740  EIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSF----TCLRMELENILGQLSV 795
            ++  +++ G  L +P  C + +++LM  CW  +PK RPSF    + ++ E+E    ++S 
Sbjct: 1220 QVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSF 1279

Query: 796  LSASQDPLYINIERAEEP-----------TAGGSLELPGRDQPYSGAGDGSGMGAV 840
              + ++ L    E   EP            +  SL LP R   +  A +G G G +
Sbjct: 1280 YYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLPDRHSGHK-AENGPGPGVL 1334


>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
          Length = 1370

 Score =  218 bits (556), Expect = 2e-56
 Identities = 160/518 (30%), Positives = 253/518 (48%), Gaps = 62/518 (11%)

Query: 292  TNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNL-----HAIRTDSGLILEWEEVI 346
            T Y + ++  N   P        + +    P +   ++     H I  ++ + L W+E  
Sbjct: 804  TGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQE-- 861

Query: 347  PEAPLEGPLGPYKLSWVQDNGTQDELTVEGTR------ANLTGWDPQKDLIVRVCVSNAV 400
            P+ P  G +  Y++S+ +    +  L V            L G  P  +  VR+  ++  
Sbjct: 862  PKEP-NGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPG-NYSVRIRATSLA 919

Query: 401  GCGPWSQPLVVSSHDRAGQQGPPHSRTSWV--PVVLGVLTALVTAAALALILLRKRRKET 458
            G G W++P      D       P +    +  P++   L ++V  +    + LRKR+ + 
Sbjct: 920  GNGSWTEPTYFYVTDYLDV---PSNIAKIIIGPLIFVFLFSVVIGSIY--LFLRKRQPDG 974

Query: 459  RFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQF 518
              G  + S                     PE + A+ D    S  + ++ E   +  ++ 
Sbjct: 975  PLGPLYAS-------------------SNPEYLSAS-DVFPCSVYVPDEWE---VSREKI 1011

Query: 519  TLGRMLGKGEFGSVREAQLKQ--EDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFD 576
            TL R LG+G FG V E   +   +  +  +VAVK +         IE FL EA+ MK F 
Sbjct: 1012 TLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIE-FLNEASVMKGFT 1070

Query: 577  HPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASR--IGENPFNLP--LQTL 632
              HV +L+GV  + +        +V++  M HGDL ++L + R     NP   P  LQ +
Sbjct: 1071 CHHVVRLLGVVSKGQPT------LVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEM 1124

Query: 633  IRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCAS 692
            I+   +IA GM YL+++ F+HRDLAARNCM+A D TV + DFG++R IY  DYYR+G   
Sbjct: 1125 IQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKG 1184

Query: 693  KLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLK 752
             LPV+W+A ESL D ++T  SD+W+FGV +WEI +  + PY G+ N ++  +++ G  L 
Sbjct: 1185 LLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLD 1244

Query: 753  QPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENIL 790
            QP  C E V DLM  CW  +PK RP+F    +E+ N+L
Sbjct: 1245 QPDNCPERVTDLMRMCWQFNPKMRPTF----LEIVNLL 1278


>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
          Length = 1382

 Score =  218 bits (556), Expect = 2e-56
 Identities = 160/518 (30%), Positives = 253/518 (48%), Gaps = 62/518 (11%)

Query: 292  TNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNL-----HAIRTDSGLILEWEEVI 346
            T Y + ++  N   P        + +    P +   ++     H I  ++ + L W+E  
Sbjct: 816  TGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQE-- 873

Query: 347  PEAPLEGPLGPYKLSWVQDNGTQDELTVEGTR------ANLTGWDPQKDLIVRVCVSNAV 400
            P+ P  G +  Y++S+ +    +  L V            L G  P  +  VR+  ++  
Sbjct: 874  PKEP-NGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPG-NYSVRIRATSLA 931

Query: 401  GCGPWSQPLVVSSHDRAGQQGPPHSRTSWV--PVVLGVLTALVTAAALALILLRKRRKET 458
            G G W++P      D       P +    +  P++   L ++V  +    + LRKR+ + 
Sbjct: 932  GNGSWTEPTYFYVTDYLDV---PSNIAKIIIGPLIFVFLFSVVIGSIY--LFLRKRQPDG 986

Query: 459  RFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQF 518
              G  + S                     PE + A+ D    S  + ++ E   +  ++ 
Sbjct: 987  PLGPLYAS-------------------SNPEYLSAS-DVFPCSVYVPDEWE---VSREKI 1023

Query: 519  TLGRMLGKGEFGSVREAQLKQ--EDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFD 576
            TL R LG+G FG V E   +   +  +  +VAVK +         IE FL EA+ MK F 
Sbjct: 1024 TLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIE-FLNEASVMKGFT 1082

Query: 577  HPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASR--IGENPFNLP--LQTL 632
              HV +L+GV  + +        +V++  M HGDL ++L + R     NP   P  LQ +
Sbjct: 1083 CHHVVRLLGVVSKGQPT------LVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEM 1136

Query: 633  IRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCAS 692
            I+   +IA GM YL+++ F+HRDLAARNCM+A D TV + DFG++R IY  DYYR+G   
Sbjct: 1137 IQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKG 1196

Query: 693  KLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLK 752
             LPV+W+A ESL D ++T  SD+W+FGV +WEI +  + PY G+ N ++  +++ G  L 
Sbjct: 1197 LLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLD 1256

Query: 753  QPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENIL 790
            QP  C E V DLM  CW  +PK RP+F    +E+ N+L
Sbjct: 1257 QPDNCPERVTDLMRMCWQFNPKMRPTF----LEIVNLL 1290


>gi|221316650 ephrin receptor EphA1 [Homo sapiens]
          Length = 976

 Score =  216 bits (550), Expect = 8e-56
 Identities = 186/623 (29%), Positives = 285/623 (45%), Gaps = 76/623 (12%)

Query: 198 STMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGAD--GRALL 255
           +T+ +CE+ + +  A      V     P+AP N++ +  S +  S+ W P AD  GR  +
Sbjct: 308 ATICTCESGHYR--APGEGPQVACTGPPSAPRNLSFSA-SGTQLSLRWEPPADTGGRQDV 364

Query: 256 -------------------QSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSL 296
                              Q C V V  +PG   +    V V         L P  NY+ 
Sbjct: 365 RYSVRCSQCQGTAQDGGPCQPCGVGVHFSPGARGLTTPAVHV-------NGLEPYANYTF 417

Query: 297 RVRCANA---LGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSG-LILEWEEVIPEAPLE 352
            V   N    LG S +A      + G A + +  +L  ++ +   L L W    P +P  
Sbjct: 418 NVEAQNGVSGLGSSGHASTSVSISMGHAESLSGLSLRLVKKEPRQLELTWAGSRPRSP-- 475

Query: 353 GPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVS 412
           G    Y+L  +  +  + ++ +E  R  LT   P    IVRV +   +G GP+S      
Sbjct: 476 GANLTYELHVLNQDEERYQMVLE-PRVLLTELQPDTTYIVRVRMLTPLGPGPFSP----- 529

Query: 413 SHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALAL--ILLRKRRKETRFGQAFDSVMAR 470
             D   +  PP SR      ++ V+  L+  AAL L  ++ R RR + +  Q        
Sbjct: 530 --DHEFRTSPPVSRGLTGGEIVAVIFGLLLGAALLLGILVFRSRRAQRQRQQRQRD---- 583

Query: 471 GEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVL-IPEQQFTLGRMLGKGEF 529
                    A   +RE    ++  +D     D  +  L+    +      +  ++G+GEF
Sbjct: 584 --------RATDVDREDKLWLKPYVDLQAYEDPAQGALDFTRELDPAWLMVDTVIGEGEF 635

Query: 530 GSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLR 589
           G V    L+        VA+K LK D         FLREA  M +F HPH+  L GV  +
Sbjct: 636 GEVYRGTLRLPSQDCKTVAIKTLK-DTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTK 694

Query: 590 SRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSR 649
                R PI M+I  FM++G L AFL      E    L    L+  +  IA GM YLS+ 
Sbjct: 695 -----RKPI-MIITEFMENGALDAFLR-----EREDQLVPGQLVAMLQGIASGMNYLSNH 743

Query: 650 NFIHRDLAARNCMLAEDMTVCVADFGLSRKI--YSGDYYRQGCASKLPVKWLALESLADN 707
           N++HRDLAARN ++ +++   V+DFGL+R +  + G Y  QG   K+P++W A E++A  
Sbjct: 744 NYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQG--GKIPIRWTAPEAIAHR 801

Query: 708 LYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQ 767
           ++T  SDVW+FG+ MWE+++ G  PY  + N E+   +  G RL  P +C   +Y+LM  
Sbjct: 802 IFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKN 861

Query: 768 CWSADPKQRPSFTCLRMELENIL 790
           CW+ D  +RP F  L+  LE +L
Sbjct: 862 CWAYDRARRPHFQKLQAHLEQLL 884


>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
            domains 1 [Homo sapiens]
          Length = 1138

 Score =  214 bits (544), Expect = 4e-55
 Identities = 170/540 (31%), Positives = 261/540 (48%), Gaps = 63/540 (11%)

Query: 282  TCLLRDLVPATNYSLRVRCANA--LGPSPYADWVPFQTKGLAPASAPQNLHA-IRTDSGL 338
            T LL  L P T+Y L V+  +   LGP+     V     G     AP++LHA   +DS +
Sbjct: 604  TALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSG---PPAPRHLHAQALSDSEI 660

Query: 339  ILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTV-----EGTRANLTGWDPQKDLIVR 393
             L W+   PEA L GP+  Y +      G  D L +     E T   + G +     + R
Sbjct: 661  QLTWKH--PEA-LPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFR 717

Query: 394  VCVSNAVGCGPWSQPLVVSS------------HDRAGQQGPPHSRTSWVPVVLGVLTALV 441
            +  S   G G WS  +  S+              RA ++G        V   +      +
Sbjct: 718  MRAS-IQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTI 776

Query: 442  TAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGIS 501
             AA L L+ +R+     R  + F      GE  +   ++ +    R  +++         
Sbjct: 777  LAALLTLVCIRRSCLHRR--RTFTYQSGSGEETILQFSSGTLTLTRRPKLQP-------- 826

Query: 502  DELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSD 561
                E L   ++  +  T   ++G+G FG V  A +K+ DG  +  A+KMLK +  + +D
Sbjct: 827  ----EPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKK-DGLKMNAAIKMLK-EYASEND 880

Query: 562  IEEFLREAACM-KEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRI 620
              +F  E   + K   HP++  L+G     + +G L I +   P+   G+L  FL  SR+
Sbjct: 881  HRDFAGELEVLCKLGHHPNIINLLGAC---KNRGYLYIAIEYAPY---GNLLDFLRKSRV 934

Query: 621  GENP----------FNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVC 670
             E              L  + L+RF  D A GM+YLS + FIHRDLAARN ++ E++   
Sbjct: 935  LETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASK 994

Query: 671  VADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQ 730
            +ADFGLSR     + Y +    +LPV+W+A+ESL  ++YT +SDVW+FGV +WEI++ G 
Sbjct: 995  IADFGLSR---GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGG 1051

Query: 731  TPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENIL 790
            TPY G+  AE+Y  L  G R++QP  C ++VY+LM QCW   P +RP F  + ++L  +L
Sbjct: 1052 TPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRML 1111


>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
          Length = 2347

 Score =  213 bits (543), Expect = 5e-55
 Identities = 167/549 (30%), Positives = 274/549 (49%), Gaps = 82/549 (14%)

Query: 279  PPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAP--ASAPQNLHAIRTDS 336
            P + C + +L P T+Y++RV      G +  +    F+TK   P     P+ L   +   
Sbjct: 1710 PAYVCNITNLQPYTSYNVRVVVVYKTGENSTSLPESFKTKAGVPNKPGIPKLLEGSKNS- 1768

Query: 337  GLILEWEEV------IPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQ--K 388
               ++WE+       I    LE  +     + +Q+   + ++T  G+ +++  W  +  K
Sbjct: 1769 ---IQWEKAEDNGCRITYYILE--IRKSTSNNLQNQNLRWKMTFNGSCSSVCTWKSKNLK 1823

Query: 389  DLI-VRVCVSNAVGCGPWS---QPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAA 444
             +   RV  +N +G G +S   + +++   D             W+P    +LT +V   
Sbjct: 1824 GIFQFRVVAANNLGFGEYSGISENIILVGDD------------FWIPETSFILTIIVGIF 1871

Query: 445  ALALILL----RKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGI 500
             +  I L     +R K  +  +   +V+   +  +               +      +G+
Sbjct: 1872 LVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKEL-------------AELRGLAAGVGL 1918

Query: 501  SDEL--------KEKLEDV-LIPEQQFTLGRMLGKGEFGSVREAQLKQEDG---SFVKVA 548
            ++          +E++E++   P ++ TL  +LG G FG V E       G     +KVA
Sbjct: 1919 ANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVA 1978

Query: 549  VKMLKADIIASSDIE--EFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFM 606
            VK LK     S+D E  EFL+EA  M +F+HP++ K +GV L +  +       +IL  M
Sbjct: 1979 VKTLKK---GSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQ------YIILELM 2029

Query: 607  KHGDLHAFLLASRIGENPFNLPLQTLIRFM---VDIACGMEYLSSRNFIHRDLAARNCML 663
            + GDL  +L  +R+    F  PL TL+  +   VDI+ G  YL   +FIHRDLAARNC++
Sbjct: 2030 EGGDLLTYLRKARMAT--FYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLV 2087

Query: 664  A-EDMT----VCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAF 718
            + +D T    V + DFGL+R IY  DYYR+     LPV+W+A ESL D ++T QSDVW+F
Sbjct: 2088 SVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSF 2147

Query: 719  GVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPS 778
            G+ +WEI+T G  PY    N ++ NY+  G RL+ P  C +D+++LM QCW+ +P QRP+
Sbjct: 2148 GILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPT 2207

Query: 779  FTCLRMELE 787
            F  ++ +L+
Sbjct: 2208 FHRIQDQLQ 2216


>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
          Length = 1072

 Score =  210 bits (535), Expect = 4e-54
 Identities = 135/384 (35%), Positives = 204/384 (53%), Gaps = 37/384 (9%)

Query: 432  VVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERI 491
            +   VL + + +  L+   +    K         + M    PA  F  + S +  R    
Sbjct: 638  IAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGAR---- 693

Query: 492  EATLDSLG--ISDELKEKLEDVL--IPEQQFTLGRMLGKGEFGSVREA---QLKQEDGSF 544
              +LDS+   +S +  + LED     P +   LG+ LG+GEFG V +A    LK   G +
Sbjct: 694  RPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAG-Y 752

Query: 545  VKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILP 604
              VAVKMLK +  + S++ + L E   +K+ +HPHV KL G   +    G L   ++I+ 
Sbjct: 753  TTVAVKMLKENA-SPSELRDLLSEFNVLKQVNHPHVIKLYGACSQD---GPL---LLIVE 805

Query: 605  FMKHGDLHAFLLASR-IGENPFN-----------------LPLQTLIRFMVDIACGMEYL 646
            + K+G L  FL  SR +G                      L +  LI F   I+ GM+YL
Sbjct: 806  YAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL 865

Query: 647  SSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLAD 706
            +    +HRDLAARN ++AE   + ++DFGLSR +Y  D Y +    ++PVKW+A+ESL D
Sbjct: 866  AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFD 925

Query: 707  NLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMY 766
            ++YT QSDVW+FGV +WEI+T G  PY GI    ++N L  G+R+++P  C E++Y LM 
Sbjct: 926  HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLML 985

Query: 767  QCWSADPKQRPSFTCLRMELENIL 790
            QCW  +P +RP F  +  +LE ++
Sbjct: 986  QCWKQEPDKRPVFADISKDLEKMM 1009


>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
          Length = 1114

 Score =  210 bits (535), Expect = 4e-54
 Identities = 135/384 (35%), Positives = 204/384 (53%), Gaps = 37/384 (9%)

Query: 432  VVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERI 491
            +   VL + + +  L+   +    K         + M    PA  F  + S +  R    
Sbjct: 638  IAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGAR---- 693

Query: 492  EATLDSLG--ISDELKEKLEDVL--IPEQQFTLGRMLGKGEFGSVREA---QLKQEDGSF 544
              +LDS+   +S +  + LED     P +   LG+ LG+GEFG V +A    LK   G +
Sbjct: 694  RPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAG-Y 752

Query: 545  VKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILP 604
              VAVKMLK +  + S++ + L E   +K+ +HPHV KL G   +    G L   ++I+ 
Sbjct: 753  TTVAVKMLKENA-SPSELRDLLSEFNVLKQVNHPHVIKLYGACSQD---GPL---LLIVE 805

Query: 605  FMKHGDLHAFLLASR-IGENPFN-----------------LPLQTLIRFMVDIACGMEYL 646
            + K+G L  FL  SR +G                      L +  LI F   I+ GM+YL
Sbjct: 806  YAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL 865

Query: 647  SSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLAD 706
            +    +HRDLAARN ++AE   + ++DFGLSR +Y  D Y +    ++PVKW+A+ESL D
Sbjct: 866  AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFD 925

Query: 707  NLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMY 766
            ++YT QSDVW+FGV +WEI+T G  PY GI    ++N L  G+R+++P  C E++Y LM 
Sbjct: 926  HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLML 985

Query: 767  QCWSADPKQRPSFTCLRMELENIL 790
            QCW  +P +RP F  +  +LE ++
Sbjct: 986  QCWKQEPDKRPVFADISKDLEKMM 1009


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score =  209 bits (532), Expect = 9e-54
 Identities = 136/370 (36%), Positives = 192/370 (51%), Gaps = 31/370 (8%)

Query: 519 TLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHP 578
           T+   LG G++G V E   K+     + VAVK LK D +   ++EEFL+EAA MKE  HP
Sbjct: 243 TMKHKLGGGQYGEVYEGVWKKYS---LTVAVKTLKEDTM---EVEEFLKEAAVMKEIKHP 296

Query: 579 HVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVD 638
           ++ +L+GV  R       P   +I  FM +G+L  +L       N   +    L+     
Sbjct: 297 NLVQLLGVCTRE------PPFYIITEFMTYGNLLDYLREC----NRQEVNAVVLLYMATQ 346

Query: 639 IACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKW 698
           I+  MEYL  +NFIHRDLAARNC++ E+  V VADFGLSR + +GD Y     +K P+KW
Sbjct: 347 ISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR-LMTGDTYTAHAGAKFPIKW 405

Query: 699 LALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECM 758
            A ESLA N ++++SDVWAFGV +WEI T G +PY GI+ +++Y  L    R+++P  C 
Sbjct: 406 TAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP 465

Query: 759 EDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGS 818
           E VY+LM  CW  +P  RPSF  +    E +  + S+    +  L     R    T   +
Sbjct: 466 EKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQA 525

Query: 819 LELPGRDQPYSGAGD----------GSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPE 868
            ELP + +    A +              G     P D    ++P      P +    PE
Sbjct: 526 PELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSP----LLPRKERGPPE 581

Query: 869 SPLNETQRLL 878
             LNE +RLL
Sbjct: 582 GGLNEDERLL 591


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score =  209 bits (532), Expect = 9e-54
 Identities = 136/370 (36%), Positives = 192/370 (51%), Gaps = 31/370 (8%)

Query: 519 TLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHP 578
           T+   LG G++G V E   K+     + VAVK LK D +   ++EEFL+EAA MKE  HP
Sbjct: 262 TMKHKLGGGQYGEVYEGVWKKYS---LTVAVKTLKEDTM---EVEEFLKEAAVMKEIKHP 315

Query: 579 HVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVD 638
           ++ +L+GV  R       P   +I  FM +G+L  +L       N   +    L+     
Sbjct: 316 NLVQLLGVCTRE------PPFYIITEFMTYGNLLDYLREC----NRQEVNAVVLLYMATQ 365

Query: 639 IACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKW 698
           I+  MEYL  +NFIHRDLAARNC++ E+  V VADFGLSR + +GD Y     +K P+KW
Sbjct: 366 ISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR-LMTGDTYTAHAGAKFPIKW 424

Query: 699 LALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECM 758
            A ESLA N ++++SDVWAFGV +WEI T G +PY GI+ +++Y  L    R+++P  C 
Sbjct: 425 TAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP 484

Query: 759 EDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGS 818
           E VY+LM  CW  +P  RPSF  +    E +  + S+    +  L     R    T   +
Sbjct: 485 EKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQA 544

Query: 819 LELPGRDQPYSGAGD----------GSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPE 868
            ELP + +    A +              G     P D    ++P      P +    PE
Sbjct: 545 PELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSP----LLPRKERGPPE 600

Query: 869 SPLNETQRLL 878
             LNE +RLL
Sbjct: 601 GGLNEDERLL 610


>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
          Length = 869

 Score =  205 bits (522), Expect = 1e-52
 Identities = 129/312 (41%), Positives = 174/312 (55%), Gaps = 39/312 (12%)

Query: 504 LKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQ----LKQEDGSFVKVAVKMLKADIIAS 559
           L  KL  +  P       R +G+G FG V +A+    L  E   F  VAVKMLK +  AS
Sbjct: 561 LNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEP--FTMVAVKMLKEE--AS 616

Query: 560 SDIE-EFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVIL-PFMKHGDLHAFLLA 617
           +D++ +F REAA M EFD+P++ KL+GV     A G+   PM +L  +M +GDL+ FL +
Sbjct: 617 ADMQADFQREAALMAEFDNPNIVKLLGVC----AVGK---PMCLLFEYMAYGDLNEFLRS 669

Query: 618 --------------------SRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLA 657
                               S  G  P +   Q  I   V  A GM YLS R F+HRDLA
Sbjct: 670 MSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQV--AAGMAYLSERKFVHRDLA 727

Query: 658 ARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWA 717
            RNC++ E+M V +ADFGLSR IYS DYY+      +P++W+  ES+  N YT +SDVWA
Sbjct: 728 TRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWA 787

Query: 718 FGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRP 777
           +GV +WEI + G  PY G+ + E+  Y+  GN L  P  C  ++Y+LM  CWS  P  RP
Sbjct: 788 YGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRP 847

Query: 778 SFTCLRMELENI 789
           SFT +   LE +
Sbjct: 848 SFTSIHRILERM 859



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 42/174 (24%), Positives = 75/174 (43%), Gaps = 13/174 (7%)

Query: 44  KLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLS 103
           K+   P+ + + +G    L C+  G  +P + W+K  + ++   ++ +  S     G L 
Sbjct: 122 KITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLES-----GSLR 176

Query: 104 LKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAV 163
           + +V++ DAG+Y C  ++   T  S+ V L VE        P+   V   +   L C A 
Sbjct: 177 IHNVQKEDAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTAT 236

Query: 164 GPPEPVTIVWWRGTTKIGGPAPSPSVLN-------VTGVTQSTMFSCEAHNLKG 210
           G P P TI W      +   +   SV +          +T+  +++C A N  G
Sbjct: 237 GIPVP-TITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHG 289



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 31/117 (26%), Positives = 56/117 (47%), Gaps = 4/117 (3%)

Query: 64  CSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGG 123
           C+VE   +P+I W ++  +++  D  Y  + E   +  L++ SVE SD G Y C   +G 
Sbjct: 49  CAVESYPQPEISWTRNKILIKLFDTRY-SIRENGQL--LTILSVEDSDDGIYCCTANNGV 105

Query: 124 ETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKI 180
              +     L V+  P  T  P ++ +       L C  +G P+P ++ W +G + +
Sbjct: 106 GGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKP-SVSWIKGDSPL 161


>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
          Length = 1124

 Score =  203 bits (517), Expect = 5e-52
 Identities = 165/538 (30%), Positives = 254/538 (47%), Gaps = 53/538 (9%)

Query: 274  VVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIR 333
            + VP    + LL +L P   Y +R R           D   +    + P   P+N+    
Sbjct: 591  IKVPGNLTSVLLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQ-PENIKISN 649

Query: 334  -TDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLT-----GWDPQ 387
             T S  ++ W  ++    +      YK   VQ       + V+   A +T     G +P+
Sbjct: 650  ITHSSAVISWT-ILDGYSISSITIRYK---VQGKNEDQHVDVKIKNATITQYQLKGLEPE 705

Query: 388  KDLIVRVCVSNAVGCG--PWSQPLVVSSHDRA-GQQGPPHSRTSWVPVVLGVLTALVTAA 444
                V +   N +G     +S  LV     +A    G        +    G+    V  A
Sbjct: 706  TAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLA 765

Query: 445  ALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAAR-SFNRERPERIEATLDSLGISDE 503
             L ++ L++   + R  QAF +V  R EPAV F +   + NR+     + T+    + D 
Sbjct: 766  FLIILQLKRANVQRRMAQAFQNV--REEPAVQFNSGTLALNRKVKNNPDPTI--YPVLDW 821

Query: 504  LKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIE 563
               K +DV+            G+G FG V +A++K+ DG  +  A+K +K +  +  D  
Sbjct: 822  NDIKFQDVI------------GEGNFGQVLKARIKK-DGLRMDAAIKRMK-EYASKDDHR 867

Query: 564  EFLREAACM-KEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGE 622
            +F  E   + K   HP++  L+G       +G L + +   P   HG+L  FL  SR+ E
Sbjct: 868  DFAGELEVLCKLGHHPNIINLLGAC---EHRGYLYLAIEYAP---HGNLLDFLRKSRVLE 921

Query: 623  NP----------FNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVA 672
                          L  Q L+ F  D+A GM+YLS + FIHRDLAARN ++ E+    +A
Sbjct: 922  TDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIA 981

Query: 673  DFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTP 732
            DFGLSR     + Y +    +LPV+W+A+ESL  ++YT  SDVW++GV +WEI++ G TP
Sbjct: 982  DFGLSR---GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTP 1038

Query: 733  YAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENIL 790
            Y G+  AE+Y  L  G RL++P  C ++VYDLM QCW   P +RPSF  + + L  +L
Sbjct: 1039 YCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096


>gi|31657140 insulin receptor-related receptor precursor [Homo
            sapiens]
          Length = 1297

 Score =  203 bits (516), Expect = 7e-52
 Identities = 108/273 (39%), Positives = 164/273 (60%), Gaps = 11/273 (4%)

Query: 513  IPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASS-DIEEFLREAAC 571
            +P +Q ++ R LG+G FG V E   +  +       V +   + +AS  +  EFL+EA+ 
Sbjct: 974  VPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEASV 1033

Query: 572  MKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRI-GENPFNLP-- 628
            MK F   HV +L+GV  + +        +VI+  M  GDL + L + R   EN   LP  
Sbjct: 1034 MKAFKCHHVVRLLGVVSQGQPT------LVIMELMTRGDLKSHLRSLRPEAENNPGLPQP 1087

Query: 629  -LQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYR 687
             L  +I+   +IA GM YL++  F+HRDLAARNCM+++D TV + DFG++R +Y  DYYR
Sbjct: 1088 ALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYR 1147

Query: 688  QGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIG 747
            +G    LPV+W+A ESL D ++T  SDVW+FGV +WEI+T  + PY G+ N ++  +++ 
Sbjct: 1148 KGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMD 1207

Query: 748  GNRLKQPPECMEDVYDLMYQCWSADPKQRPSFT 780
            G  L++   C   + +LM +CW  +P+ RPSFT
Sbjct: 1208 GGVLEELEGCPLQLQELMSRCWQPNPRLRPSFT 1240


>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
          Length = 1074

 Score =  202 bits (514), Expect = 1e-51
 Identities = 113/317 (35%), Positives = 177/317 (55%), Gaps = 22/317 (6%)

Query: 510 DVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREA 569
           D  I  ++  LGR +G+G+FG V +      +   + VA+K  K +  + S  E+FL+EA
Sbjct: 436 DYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCK-NCTSDSVREKFLQEA 494

Query: 570 ACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPL 629
             M++FDHPH+ KL+GV   +      P+  +I+     G+L +FL   +     ++L L
Sbjct: 495 LTMRQFDHPHIVKLIGVITEN------PV-WIIMELCTLGELRSFLQVRK-----YSLDL 542

Query: 630 QTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQG 689
            +LI +   ++  + YL S+ F+HRD+AARN +++ +  V + DFGLSR +    YY+  
Sbjct: 543 ASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKAS 602

Query: 690 CASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGN 749
              KLP+KW+A ES+    +T  SDVW FGV MWEI+  G  P+ G++N ++   +  G 
Sbjct: 603 -KGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGE 661

Query: 750 RLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIER 809
           RL  PP C   +Y LM +CW+ DP +RP FT L+ +L  IL +      +Q    + +E 
Sbjct: 662 RLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEE----EKAQQEERMRMES 717

Query: 810 AEEPT----AGGSLELP 822
             + T    +GGS E P
Sbjct: 718 RRQATVSWDSGGSDEAP 734


>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
          Length = 1052

 Score =  202 bits (514), Expect = 1e-51
 Identities = 113/317 (35%), Positives = 177/317 (55%), Gaps = 22/317 (6%)

Query: 510 DVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREA 569
           D  I  ++  LGR +G+G+FG V +      +   + VA+K  K +  + S  E+FL+EA
Sbjct: 414 DYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCK-NCTSDSVREKFLQEA 472

Query: 570 ACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPL 629
             M++FDHPH+ KL+GV   +      P+  +I+     G+L +FL   +     ++L L
Sbjct: 473 LTMRQFDHPHIVKLIGVITEN------PV-WIIMELCTLGELRSFLQVRK-----YSLDL 520

Query: 630 QTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQG 689
            +LI +   ++  + YL S+ F+HRD+AARN +++ +  V + DFGLSR +    YY+  
Sbjct: 521 ASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKAS 580

Query: 690 CASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGN 749
              KLP+KW+A ES+    +T  SDVW FGV MWEI+  G  P+ G++N ++   +  G 
Sbjct: 581 -KGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGE 639

Query: 750 RLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIER 809
           RL  PP C   +Y LM +CW+ DP +RP FT L+ +L  IL +      +Q    + +E 
Sbjct: 640 RLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEE----EKAQQEERMRMES 695

Query: 810 AEEPT----AGGSLELP 822
             + T    +GGS E P
Sbjct: 696 RRQATVSWDSGGSDEAP 712


>gi|17975768 ephrin receptor EphB3 precursor [Homo sapiens]
          Length = 998

 Score =  202 bits (513), Expect = 1e-51
 Identities = 160/532 (30%), Positives = 255/532 (47%), Gaps = 56/532 (10%)

Query: 288 LVPATNYSLRVRCANAL-GPSP----YADWVPFQTKGLAPASAPQ-NLHAIRTDSGLILE 341
           L+  T Y+  V+  N + G SP    YA  V   T   AP+  P   LH+  + S L L 
Sbjct: 415 LLAHTRYTFEVQAVNGVSGKSPLPPRYAA-VNITTNQAAPSEVPTLRLHS-SSGSSLTLS 472

Query: 342 WEEVIPEAPLEGPLGPYKLSWVQDN-GTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAV 400
           W    PE P  G +  Y++ + + + G    +T +     L G  P    +V+V      
Sbjct: 473 WAP--PERP-NGVILDYEMKYFEKSEGIASTVTSQMNSVQLDGLRPDARYVVQVRARTVA 529

Query: 401 GCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTA----LVTAAALALILLRKRR- 455
           G G +S+P    +    G           +P+++G  TA    +V    +A++ LRK+R 
Sbjct: 530 GYGQYSRPAEFETTSERGSGA--QQLQEQLPLIVGSATAGLVFVVAVVVIAIVCLRKQRH 587

Query: 456 -KETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIP 514
             ++ + +     +A G           F  E P   EA  +     D    K+E+V+  
Sbjct: 588 GSDSEYTEKLQQYIAPGMKVY----IDPFTYEDPN--EAVREFAKEIDVSCVKIEEVI-- 639

Query: 515 EQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKE 574
                     G GEFG V   +LKQ     V VA+K LK          +FL EA+ M +
Sbjct: 640 ----------GAGEFGEVCRGRLKQPGRREVFVAIKTLKVGY-TERQRRDFLSEASIMGQ 688

Query: 575 FDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIR 634
           FDHP++ +L GV  +SR     P+ M++  FM++  L +FL   R+ +  F +    L+ 
Sbjct: 689 FDHPNIIRLEGVVTKSR-----PV-MILTEFMENCALDSFL---RLNDGQFTVI--QLVG 737

Query: 635 FMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIY---SGDYYRQGCA 691
            +  IA GM+YLS  N++HRDLAARN ++  ++   V+DFGLSR +    S   Y     
Sbjct: 738 MLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLG 797

Query: 692 SKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRL 751
            K+P++W A E++A   +T  SDVW++G+ MWE+M+ G+ PY  + N ++ N +    RL
Sbjct: 798 GKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRL 857

Query: 752 KQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENIL---GQLSVLSASQ 800
             P +C   ++ LM  CW  D   RP F+ +   L+ ++     L V++++Q
Sbjct: 858 PPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLIRNAASLKVIASAQ 909


>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
          Length = 1620

 Score =  201 bits (511), Expect = 3e-51
 Identities = 133/384 (34%), Positives = 196/384 (51%), Gaps = 33/384 (8%)

Query: 432  VVLGVLT-ALVTAAALAL--ILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERP 488
            ++L V+T ALV A  LA   I++  RRK          + +        R +       P
Sbjct: 1035 LILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNP 1094

Query: 489  ERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLK--QEDGSFVK 546
                A   S  ISD LKE      +P +  TL R LG G FG V E Q+     D S ++
Sbjct: 1095 NYCFAGKTS-SISD-LKE------VPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQ 1146

Query: 547  VAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFM 606
            VAVK L  ++ +  D  +FL EA  + +F+H ++ + +GVSL+S  +       ++L  M
Sbjct: 1147 VAVKTLP-EVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPR------FILLELM 1199

Query: 607  KHGDLHAFLLASRIGEN-PFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLA- 664
              GDL +FL  +R   + P +L +  L+    DIACG +YL   +FIHRD+AARNC+L  
Sbjct: 1200 AGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTC 1259

Query: 665  --EDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTM 722
                    + DFG++R IY   YYR+G  + LPVKW+  E+  + ++T ++D W+FGV +
Sbjct: 1260 PGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLL 1319

Query: 723  WEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCL 782
            WEI + G  PY    N E+  ++  G R+  P  C   VY +M QCW   P+ RP+F  +
Sbjct: 1320 WEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAII 1379

Query: 783  RMELENILGQLSVLSASQDPLYIN 806
               +E           +QDP  IN
Sbjct: 1380 LERIE---------YCTQDPDVIN 1394


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score =  200 bits (508), Expect = 6e-51
 Identities = 113/277 (40%), Positives = 159/277 (57%), Gaps = 17/277 (6%)

Query: 519 TLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHP 578
           T+   LG G++G V     K+     + VAVK LK D +   ++EEFL+EAA MKE  HP
Sbjct: 274 TMKHKLGGGQYGEVYVGVWKKYS---LTVAVKTLKEDTM---EVEEFLKEAAVMKEIKHP 327

Query: 579 HVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVD 638
           ++ +L+GV          P   ++  +M +G+L  +L       N   +    L+     
Sbjct: 328 NLVQLLGVCTLE------PPFYIVTEYMPYGNLLDYLREC----NREEVTAVVLLYMATQ 377

Query: 639 IACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKW 698
           I+  MEYL  +NFIHRDLAARNC++ E+  V VADFGLSR + +GD Y     +K P+KW
Sbjct: 378 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGAKFPIKW 436

Query: 699 LALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECM 758
            A ESLA N ++++SDVWAFGV +WEI T G +PY GI+ +++Y+ L  G R++QP  C 
Sbjct: 437 TAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP 496

Query: 759 EDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSV 795
             VY+LM  CW   P  RPSF       E +    S+
Sbjct: 497 PKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSI 533


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score =  200 bits (508), Expect = 6e-51
 Identities = 113/277 (40%), Positives = 159/277 (57%), Gaps = 17/277 (6%)

Query: 519 TLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHP 578
           T+   LG G++G V     K+     + VAVK LK D +   ++EEFL+EAA MKE  HP
Sbjct: 289 TMKHKLGGGQYGEVYVGVWKKYS---LTVAVKTLKEDTM---EVEEFLKEAAVMKEIKHP 342

Query: 579 HVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVD 638
           ++ +L+GV          P   ++  +M +G+L  +L       N   +    L+     
Sbjct: 343 NLVQLLGVCTLE------PPFYIVTEYMPYGNLLDYLREC----NREEVTAVVLLYMATQ 392

Query: 639 IACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKW 698
           I+  MEYL  +NFIHRDLAARNC++ E+  V VADFGLSR + +GD Y     +K P+KW
Sbjct: 393 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGAKFPIKW 451

Query: 699 LALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECM 758
            A ESLA N ++++SDVWAFGV +WEI T G +PY GI+ +++Y+ L  G R++QP  C 
Sbjct: 452 TAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP 511

Query: 759 EDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSV 795
             VY+LM  CW   P  RPSF       E +    S+
Sbjct: 512 PKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSI 548


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score =  200 bits (508), Expect = 6e-51
 Identities = 113/277 (40%), Positives = 159/277 (57%), Gaps = 17/277 (6%)

Query: 519 TLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHP 578
           T+   LG G++G V     K+     + VAVK LK D +   ++EEFL+EAA MKE  HP
Sbjct: 268 TMKHKLGGGQYGEVYVGVWKKYS---LTVAVKTLKEDTM---EVEEFLKEAAVMKEIKHP 321

Query: 579 HVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVD 638
           ++ +L+GV          P   ++  +M +G+L  +L       N   +    L+     
Sbjct: 322 NLVQLLGVCTLE------PPFYIVTEYMPYGNLLDYLREC----NREEVTAVVLLYMATQ 371

Query: 639 IACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKW 698
           I+  MEYL  +NFIHRDLAARNC++ E+  V VADFGLSR + +GD Y     +K P+KW
Sbjct: 372 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGAKFPIKW 430

Query: 699 LALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECM 758
            A ESLA N ++++SDVWAFGV +WEI T G +PY GI+ +++Y+ L  G R++QP  C 
Sbjct: 431 TAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP 490

Query: 759 EDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSV 795
             VY+LM  CW   P  RPSF       E +    S+
Sbjct: 491 PKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSI 527


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score =  200 bits (508), Expect = 6e-51
 Identities = 113/277 (40%), Positives = 159/277 (57%), Gaps = 17/277 (6%)

Query: 519 TLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHP 578
           T+   LG G++G V     K+     + VAVK LK D +   ++EEFL+EAA MKE  HP
Sbjct: 274 TMKHKLGGGQYGEVYVGVWKKYS---LTVAVKTLKEDTM---EVEEFLKEAAVMKEIKHP 327

Query: 579 HVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVD 638
           ++ +L+GV          P   ++  +M +G+L  +L       N   +    L+     
Sbjct: 328 NLVQLLGVCTLE------PPFYIVTEYMPYGNLLDYLREC----NREEVTAVVLLYMATQ 377

Query: 639 IACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKW 698
           I+  MEYL  +NFIHRDLAARNC++ E+  V VADFGLSR + +GD Y     +K P+KW
Sbjct: 378 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGAKFPIKW 436

Query: 699 LALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECM 758
            A ESLA N ++++SDVWAFGV +WEI T G +PY GI+ +++Y+ L  G R++QP  C 
Sbjct: 437 TAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP 496

Query: 759 EDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSV 795
             VY+LM  CW   P  RPSF       E +    S+
Sbjct: 497 PKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSI 533


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score =  200 bits (508), Expect = 6e-51
 Identities = 113/277 (40%), Positives = 159/277 (57%), Gaps = 17/277 (6%)

Query: 519 TLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHP 578
           T+   LG G++G V     K+     + VAVK LK D +   ++EEFL+EAA MKE  HP
Sbjct: 253 TMKHKLGGGQYGEVYVGVWKKYS---LTVAVKTLKEDTM---EVEEFLKEAAVMKEIKHP 306

Query: 579 HVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVD 638
           ++ +L+GV          P   ++  +M +G+L  +L       N   +    L+     
Sbjct: 307 NLVQLLGVCTLE------PPFYIVTEYMPYGNLLDYLREC----NREEVTAVVLLYMATQ 356

Query: 639 IACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKW 698
           I+  MEYL  +NFIHRDLAARNC++ E+  V VADFGLSR + +GD Y     +K P+KW
Sbjct: 357 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGAKFPIKW 415

Query: 699 LALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECM 758
            A ESLA N ++++SDVWAFGV +WEI T G +PY GI+ +++Y+ L  G R++QP  C 
Sbjct: 416 TAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP 475

Query: 759 EDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSV 795
             VY+LM  CW   P  RPSF       E +    S+
Sbjct: 476 PKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSI 512


>gi|54607018 RYK receptor-like tyrosine kinase isoform 2 [Homo
           sapiens]
          Length = 607

 Score =  196 bits (497), Expect = 1e-49
 Identities = 107/280 (38%), Positives = 160/280 (57%), Gaps = 8/280 (2%)

Query: 503 ELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQE-DGSFVKVAVKMLKADIIASSD 561
           E K K++D+ I  ++ TL  +L +G FG +    L  E D +  K A      D  +   
Sbjct: 315 EAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQ 374

Query: 562 IEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIG 621
           +   L E+  ++   H ++  +  V +    K     PMVILP+M  G+L  FL   ++ 
Sbjct: 375 VTMMLTESCKLRGLHHRNLLPITHVCIEEGEK-----PMVILPYMNWGNLKLFLRQCKLV 429

Query: 622 E--NPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRK 679
           E  NP  +  Q L+   + IACGM YL+ R  IH+DLAARNC++ + + V + D  LSR 
Sbjct: 430 EANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRD 489

Query: 680 IYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENA 739
           ++  DY+  G     PV+W+ALESL +N ++  SDVWAFGVT+WE+MT GQTPY  I+  
Sbjct: 490 LFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPF 549

Query: 740 EIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSF 779
           E+  YL  G R+ QP  C ++++ +M  CW+ DP++RP F
Sbjct: 550 EMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKF 589



 Score = 33.5 bits (75), Expect = 0.90
 Identities = 27/65 (41%), Positives = 29/65 (44%), Gaps = 8/65 (12%)

Query: 7  MGRPGLPPLP------LPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPV 60
          +GRPG   LP       PPPP L LLLA L   LLP   AA       P   + S G  V
Sbjct: 7  LGRPGRSCLPGARGLRAPPPPPLLLLLALLP--LLPAPGAAAAPAPRPPELQSASAGPSV 64

Query: 61 KLNCS 65
           L  S
Sbjct: 65 SLYLS 69


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.416 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,781,295
Number of Sequences: 37866
Number of extensions: 2015324
Number of successful extensions: 12534
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 660
Number of HSP's successfully gapped in prelim test: 384
Number of HSP's that attempted gapping in prelim test: 8381
Number of HSP's gapped (non-prelim): 2896
length of query: 890
length of database: 18,247,518
effective HSP length: 111
effective length of query: 779
effective length of database: 14,044,392
effective search space: 10940581368
effective search space used: 10940581368
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.