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Search of human proteins with 27545328
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27545328 leucine rich repeat containing 2 [Homo sapiens]
(371 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|190014581 leucine rich repeat containing 2 [Homo sapiens] 744 0.0
gi|27545328 leucine rich repeat containing 2 [Homo sapiens] 744 0.0
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 191 9e-49
gi|238908508 leucine-rich repeat and death domain-containing pro... 103 2e-22
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 102 7e-22
gi|157743290 leucine rich repeat containing 30 [Homo sapiens] 102 7e-22
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 101 9e-22
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 99 5e-21
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 99 5e-21
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 99 6e-21
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 98 1e-20
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 92 7e-19
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 91 2e-18
gi|45827729 scribble isoform b [Homo sapiens] 89 5e-18
gi|45827731 scribble isoform a [Homo sapiens] 89 5e-18
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 86 4e-17
gi|4503743 flightless I homolog [Homo sapiens] 86 7e-17
gi|194394161 leucine rich repeat containing 57 [Homo sapiens] 85 9e-17
gi|61742786 leucine rich repeat and death domain containing prot... 85 1e-16
gi|61742784 leucine rich repeat and death domain containing prot... 85 1e-16
gi|197333706 leucine rich repeat containing 8 family, member D [... 84 2e-16
gi|34222199 leucine rich repeat containing 8 family, member D [H... 84 2e-16
gi|63003903 leucine rich repeat containing 10 [Homo sapiens] 83 3e-16
gi|193788651 leucine rich repeat containing 69 [Homo sapiens] 83 3e-16
gi|33285015 leucine rich repeat containing 28 [Homo sapiens] 81 2e-15
gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens] 80 2e-15
gi|197333692 leucine rich repeat containing 8 family, member B [... 80 4e-15
gi|21245134 leucine rich repeat containing 8 family, member B [H... 80 4e-15
gi|62241040 leucine rich repeat containing 8 family, member A [H... 77 2e-14
gi|187829877 leucine rich repeat containing 8 family, member A [... 77 2e-14
>gi|190014581 leucine rich repeat containing 2 [Homo sapiens]
Length = 371
Score = 744 bits (1921), Expect = 0.0
Identities = 371/371 (100%), Positives = 371/371 (100%)
Query: 1 MGHKVVVFDISVIRALWETRVKKHKAWQKKEVERLEKSALEKIKEEWNFVAECRRKGIPQ 60
MGHKVVVFDISVIRALWETRVKKHKAWQKKEVERLEKSALEKIKEEWNFVAECRRKGIPQ
Sbjct: 1 MGHKVVVFDISVIRALWETRVKKHKAWQKKEVERLEKSALEKIKEEWNFVAECRRKGIPQ 60
Query: 61 AVYCKNGFIDTSVRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQ 120
AVYCKNGFIDTSVRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQ
Sbjct: 61 AVYCKNGFIDTSVRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQ 120
Query: 121 THLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLK 180
THLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLK
Sbjct: 121 THLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLK 180
Query: 181 SIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQ 240
SIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQ
Sbjct: 181 SIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQ 240
Query: 241 WLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPT 300
WLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPT
Sbjct: 241 WLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPT 300
Query: 301 ALCDSSTPLKFVSLMDNPIDNAQCEDGNEIMESERDRQHFDKEVMKAYIEDLKERESVPS 360
ALCDSSTPLKFVSLMDNPIDNAQCEDGNEIMESERDRQHFDKEVMKAYIEDLKERESVPS
Sbjct: 301 ALCDSSTPLKFVSLMDNPIDNAQCEDGNEIMESERDRQHFDKEVMKAYIEDLKERESVPS 360
Query: 361 YTTKVSFSLQL 371
YTTKVSFSLQL
Sbjct: 361 YTTKVSFSLQL 371
>gi|27545328 leucine rich repeat containing 2 [Homo sapiens]
Length = 371
Score = 744 bits (1921), Expect = 0.0
Identities = 371/371 (100%), Positives = 371/371 (100%)
Query: 1 MGHKVVVFDISVIRALWETRVKKHKAWQKKEVERLEKSALEKIKEEWNFVAECRRKGIPQ 60
MGHKVVVFDISVIRALWETRVKKHKAWQKKEVERLEKSALEKIKEEWNFVAECRRKGIPQ
Sbjct: 1 MGHKVVVFDISVIRALWETRVKKHKAWQKKEVERLEKSALEKIKEEWNFVAECRRKGIPQ 60
Query: 61 AVYCKNGFIDTSVRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQ 120
AVYCKNGFIDTSVRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQ
Sbjct: 61 AVYCKNGFIDTSVRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQ 120
Query: 121 THLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLK 180
THLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLK
Sbjct: 121 THLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLK 180
Query: 181 SIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQ 240
SIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQ
Sbjct: 181 SIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQ 240
Query: 241 WLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPT 300
WLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPT
Sbjct: 241 WLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPT 300
Query: 301 ALCDSSTPLKFVSLMDNPIDNAQCEDGNEIMESERDRQHFDKEVMKAYIEDLKERESVPS 360
ALCDSSTPLKFVSLMDNPIDNAQCEDGNEIMESERDRQHFDKEVMKAYIEDLKERESVPS
Sbjct: 301 ALCDSSTPLKFVSLMDNPIDNAQCEDGNEIMESERDRQHFDKEVMKAYIEDLKERESVPS 360
Query: 361 YTTKVSFSLQL 371
YTTKVSFSLQL
Sbjct: 361 YTTKVSFSLQL 371
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 191 bits (485), Expect = 9e-49
Identities = 108/317 (34%), Positives = 183/317 (57%), Gaps = 10/317 (3%)
Query: 39 ALEKIKEEWNFVAECRRKGIPQAVYCKNGFIDTSVRLLDKIERNTLTRQSSLPKDRGKRS 98
A+ +KE W E R K + + + + F VR+ + ER +LT+ L + +
Sbjct: 10 AVNAVKEVW----EKRIKKLNEDLKREKEFQHKLVRIWE--ERVSLTK---LREKVTRED 60
Query: 99 SAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISH 158
+ ++ E W LP SL + L+EW + T + IP +I FQ + +LDL +N IS
Sbjct: 61 GRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISE 120
Query: 159 LPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTF 218
+P IG L L+EL + +N +K++P EL +C +LE+L+ + N ++ +LP ELSNL ++T
Sbjct: 121 IPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTH 180
Query: 219 VDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYS 278
+D+S N F+++P+ VL M L+WLD+ SN L LP I+R++ L + L +N++T LP +
Sbjct: 181 LDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQT 240
Query: 279 MLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDNPIDNAQCEDGNEIMESERDRQ 338
+ N+K L LV+S + L ++P + + L+FV+ DNP+ +E + E +R+
Sbjct: 241 ISNMKNLGTLVLSNNKLQDIPVCM-EEMANLRFVNFRDNPLKLKVSLPPSEGTDEEEERE 299
Query: 339 HFDKEVMKAYIEDLKER 355
F + M YI++ + R
Sbjct: 300 LFGLQFMHTYIQESRRR 316
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 103 bits (258), Expect = 2e-22
Identities = 74/247 (29%), Positives = 127/247 (51%), Gaps = 28/247 (11%)
Query: 99 SAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISH 158
S + ++G + +E+P + L +S + I + ++ LDL KNQI
Sbjct: 488 SLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKK 547
Query: 159 LPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTF 218
+PA I + +L L + N ++ P EL ENL+ LD S N +L ++ ++ NLK +
Sbjct: 548 IPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSEN-QLQKISSDICNLKGIQK 606
Query: 219 VDISANKFSSVPI--CVLR------------------------MSNLQWLDISSNNLTDL 252
++ S+N+F PI C L+ M+ L+ LDIS+N + ++
Sbjct: 607 LNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREI 666
Query: 253 PQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFV 312
P++I L L S Y N+++YLP S+L+L L L +SG++L LP+A+ + + LK +
Sbjct: 667 PRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFS-LKEI 725
Query: 313 SLMDNPI 319
+ DNP+
Sbjct: 726 NFDDNPL 732
Score = 95.1 bits (235), Expect = 9e-20
Identities = 58/212 (27%), Positives = 107/212 (50%), Gaps = 1/212 (0%)
Query: 88 SSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMR 147
SSLP + + + +S H + +P + + ++R+ + N I+ P+ ++ +
Sbjct: 201 SSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLE 260
Query: 148 ILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELP 207
IL L KN++ H+P + LK L+ LN+ +N L + P L L LD +GNL + LP
Sbjct: 261 ILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNL-ISSLP 319
Query: 208 FELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLL 267
E+ LK + + + NK + + + + ++ ++ L ++ N L + I+ EL+ +L
Sbjct: 320 KEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILIL 379
Query: 268 YKNKLTYLPYSMLNLKKLTLLVVSGDHLVELP 299
KN L +P + L L +S + L ELP
Sbjct: 380 DKNLLKNIPEKISCCAMLECLSLSDNKLTELP 411
Score = 86.3 bits (212), Expect = 4e-17
Identities = 65/250 (26%), Positives = 125/250 (50%), Gaps = 10/250 (4%)
Query: 72 SVRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNT 131
++R+L+ +E N LT + PK +L+G + LP ++E +L + +
Sbjct: 281 TLRVLN-LEYNQLT---TFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHN 336
Query: 132 LIQIIPTYIQLFQAMRI--LDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDC 189
+ + +++FQ ++I L L N++ + +I + L+ L + N LK+IP ++ C
Sbjct: 337 KLTFLA--VEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCC 394
Query: 190 ENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNL 249
LE L S N +L ELP + L + + ++ N + C+ ++N+ L+ S N +
Sbjct: 395 AMLECLSLSDN-KLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNII 453
Query: 250 TDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPL 309
TD+P +I +++ L NK+ Y P + L L L V+G+++ E+P + S L
Sbjct: 454 TDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDI-SFSKQL 512
Query: 310 KFVSLMDNPI 319
+ L +N +
Sbjct: 513 LHLELSENKL 522
Score = 84.7 bits (208), Expect = 1e-16
Identities = 63/227 (27%), Positives = 111/227 (48%), Gaps = 2/227 (0%)
Query: 93 DRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLP 152
D G + L + LP ++ +LR +S+ I IP I +R L
Sbjct: 183 DSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFY 242
Query: 153 KNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSN 212
N I + P+++ CL NL+ L++G N L+ IP L + L L+ N +L P L
Sbjct: 243 NNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYN-QLTTFPKALCF 301
Query: 213 LKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKL 272
L ++ +D++ N SS+P + + NL+ L + N LT L +I +L +++ L NKL
Sbjct: 302 LPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKL 361
Query: 273 TYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDNPI 319
+ + + N ++L +L++ + L +P + L+ +SL DN +
Sbjct: 362 EVISHKIENFRELRILILDKNLLKNIPEKI-SCCAMLECLSLSDNKL 407
Score = 80.9 bits (198), Expect = 2e-15
Identities = 54/238 (22%), Positives = 115/238 (48%), Gaps = 24/238 (10%)
Query: 88 SSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMR 147
SSLPK+ + + + T L + + ++E +++ +++I I+ F+ +R
Sbjct: 316 SSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELR 375
Query: 148 ILDLPKNQISHLPAEIGC-----------------------LKNLKELNVGFNYLKSIPP 184
IL L KN + ++P +I C L NL++L+V N + I
Sbjct: 376 ILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITD 435
Query: 185 ELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDI 244
+ N+ L+ SGN+ + ++P E+ N +++ +++S NK P+ + + +L +L +
Sbjct: 436 CISHLNNICSLEFSGNI-ITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSV 494
Query: 245 SSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
+ N ++++P DI ++L L +NKL +L L L + + + ++P ++
Sbjct: 495 NGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASI 552
Score = 69.3 bits (168), Expect = 5e-12
Identities = 54/199 (27%), Positives = 92/199 (46%), Gaps = 4/199 (2%)
Query: 90 LPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRIL 149
+P S V L + P L +L+ +S +Q I + I + ++ L
Sbjct: 548 IPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKL 607
Query: 150 DLPKNQISHLPAEIGCLKNLKELNVG---FNYLKSIPPELGDCENLERLDCSGNLELMEL 206
+ NQ H P E+ L++L++LN+ L +P EL + L+ LD S N + E+
Sbjct: 608 NFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNN-AIREI 666
Query: 207 PFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFL 266
P + L+ + + N+ S +P +L +++LQ L++S NNLT LP I + L+
Sbjct: 667 PRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEIN 726
Query: 267 LYKNKLTYLPYSMLNLKKL 285
N L P + K+L
Sbjct: 727 FDDNPLLRPPVEICKGKQL 745
Score = 67.0 bits (162), Expect = 3e-11
Identities = 45/156 (28%), Positives = 80/156 (51%), Gaps = 2/156 (1%)
Query: 149 LDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIP-PELGDCENLERLDCSGNLELMELP 207
++L + P +I +K +K L + N +K+ + GD LE L N L LP
Sbjct: 146 VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQEN-GLSSLP 204
Query: 208 FELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLL 267
E+ L + +++S N S +P + ++ N++ L +N + + P D++ L L+ L
Sbjct: 205 SEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSL 264
Query: 268 YKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALC 303
KNKL ++P ++ +LK L +L + + L P ALC
Sbjct: 265 GKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALC 300
Score = 45.4 bits (106), Expect = 8e-05
Identities = 43/180 (23%), Positives = 79/180 (43%), Gaps = 18/180 (10%)
Query: 17 WETRVKKHKAWQKKEVERLEKSALEKIKEEWNFVAECRRKGIPQAVYCKNGFIDTSVRL- 75
+ET ++ + +V L ++ L+KI + C KGI + + N FI + L
Sbjct: 568 FETFPRELCTLENLQVLDLSENQLQKISSDI-----CNLKGIQKLNFSSNQFIHFPIELC 622
Query: 76 ---------LDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREW 126
+ +I+ LTR LP + + ++S E+P ++ E +L
Sbjct: 623 QLQSLEQLNISQIKGRKLTR---LPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSL 679
Query: 127 YISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPEL 186
+ N I +P + ++ L+L N ++ LP+ I + +LKE+N N L P E+
Sbjct: 680 HAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEI 739
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 102 bits (253), Expect = 7e-22
Identities = 65/218 (29%), Positives = 105/218 (48%), Gaps = 24/218 (11%)
Query: 105 LSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIG 164
L+G H LP + QT LRE Y+ ++ P + + + I+DL +N+I +P EIG
Sbjct: 149 LTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIG 208
Query: 165 CLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISAN 224
L L++ + N L +P L C L LD S NL L +P + L+++T + +S N
Sbjct: 209 HLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNL-LHSIPKSFAELRKMTEIGLSGN 267
Query: 225 KFSSVPICVLR-----------------------MSNLQWLDISSNNLTDLPQDIDRLEE 261
+ VP + R + NL++LD+S N+L P I L+
Sbjct: 268 RLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKN 327
Query: 262 LQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELP 299
L+ L NK+ LP + +L KL +L ++G+ + P
Sbjct: 328 LEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFP 365
Score = 97.8 bits (242), Expect = 1e-20
Identities = 75/268 (27%), Positives = 128/268 (47%), Gaps = 29/268 (10%)
Query: 90 LPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRIL 149
LP + S V +LS +P S E + E +S ++ +P I + ++ +L
Sbjct: 226 LPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLL 285
Query: 150 DLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFE 209
L + L CL NL+ L++ N+L P ++ +NLE L N ++ +LP E
Sbjct: 286 YLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDN-KIGQLPSE 344
Query: 210 LSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSN---NLTDLPQDIDRLEELQSFL 266
L +L ++ + ++ N+F S P VL +++L+ L I + LT +P+ I +L+ L+
Sbjct: 345 LGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELY 404
Query: 267 LYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALC----------------------D 304
+ N L YLP S+ ++ L +L + L +LP A+C D
Sbjct: 405 IENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLD 464
Query: 305 SSTPLKFVSLMDNPIDNAQ---CEDGNE 329
S LK ++LMDNP++ C +GNE
Sbjct: 465 SLVNLKVLTLMDNPMEEPPKEVCAEGNE 492
Score = 80.1 bits (196), Expect = 3e-15
Identities = 67/256 (26%), Positives = 118/256 (46%), Gaps = 32/256 (12%)
Query: 76 LDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQI 135
+ +E + Q + P+ R+ F + S + T +P + T L E ++ N I+
Sbjct: 5 IKSVEHSPKIHQRNDPQHVNDRT--FFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEE 62
Query: 136 IPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNY----------------- 178
IP IQ + +R+L L KN + L +G L +L+ L++ +N
Sbjct: 63 IPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRE 122
Query: 179 -------LKSIPPEL-GDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVP 230
LK IP + + +LE L +GN L LP E+ N ++ + + N+F P
Sbjct: 123 LRLYQTDLKEIPVVIFKNLHHLELLGLTGN-HLKCLPKEIVNQTKLREIYLKRNQFEVFP 181
Query: 231 --ICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLL 288
+CVL L+ +D+ N + +P++I L LQ F + N L LP S+ +L++L
Sbjct: 182 QELCVLY--TLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVL 239
Query: 289 VVSGDHLVELPTALCD 304
+S + L +P + +
Sbjct: 240 DLSHNLLHSIPKSFAE 255
Score = 70.1 bits (170), Expect = 3e-12
Identities = 54/202 (26%), Positives = 91/202 (45%), Gaps = 24/202 (11%)
Query: 129 SNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGD 188
SN + IP I F + + L NQI +P EI LKN++ L + N L+S+ P LG
Sbjct: 33 SNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGL 92
Query: 189 CENLERLDCSGN-----------------------LELMELPFEL-SNLKQVTFVDISAN 224
+LE LD S N +L E+P + NL + + ++ N
Sbjct: 93 LSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGN 152
Query: 225 KFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKK 284
+P ++ + L+ + + N PQ++ L L+ L +NK+ +P + +L
Sbjct: 153 HLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTG 212
Query: 285 LTLLVVSGDHLVELPTALCDSS 306
L ++ ++L LP +LC S
Sbjct: 213 LQKFYMASNNLPVLPASLCQCS 234
>gi|157743290 leucine rich repeat containing 30 [Homo sapiens]
Length = 301
Score = 102 bits (253), Expect = 7e-22
Identities = 72/264 (27%), Positives = 130/264 (49%), Gaps = 5/264 (1%)
Query: 91 PKDRGKRSSAFV-FELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRIL 149
P+ KR V F L T++PD L + +++ +S+ ++++P + + +L
Sbjct: 40 PRSLLKRGMHHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVL 99
Query: 150 DLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFE 209
+L N++ LP E+ L+ LK L V N L +P EL C LE L S N L +LP
Sbjct: 100 NLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNC-LSQLPAC 158
Query: 210 LSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYK 269
++L ++ +++S N F+ +P+CV + L +L + SN L ++ + I L LQ F+
Sbjct: 159 FADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEG 218
Query: 270 NKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDNPIDNAQCEDGNE 329
N + P S+ + L LL ++ + + LP+ L + V + NP+D N
Sbjct: 219 NNIHSFPRSLCLVTSLELLNLNNNDIQTLPSEL---HLLCRLVRIAWNPMDKGLHISHNP 275
Query: 330 IMESERDRQHFDKEVMKAYIEDLK 353
+ + + E++ Y++D K
Sbjct: 276 LSKPLPELVEGGLEMLFGYLKDKK 299
Score = 30.0 bits (66), Expect = 3.5
Identities = 26/120 (21%), Positives = 51/120 (42%), Gaps = 2/120 (1%)
Query: 69 IDTSVRLLDKIERNTLTRQ--SSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREW 126
+ + L K+E +L+ S LP S LS + +P + L
Sbjct: 132 VPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFL 191
Query: 127 YISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPEL 186
++ + ++ I IQ +++I N I P + + +L+ LN+ N ++++P EL
Sbjct: 192 HVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSEL 251
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 101 bits (252), Expect = 9e-22
Identities = 63/201 (31%), Positives = 115/201 (57%), Gaps = 1/201 (0%)
Query: 102 VFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPA 161
V + SG T LP+S E +L +++ +Q +P I + L+L +N +++LP
Sbjct: 109 VADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPD 168
Query: 162 EIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDI 221
+ L+ L+EL++G N + ++P +G +L+ L GN +L ELP E+ NLK + +D+
Sbjct: 169 SLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGN-QLSELPQEIGNLKNLLCLDV 227
Query: 222 SANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLN 281
S N+ +P + +++L L IS N L +P I +L++L + +N+LT LP ++
Sbjct: 228 SENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGE 287
Query: 282 LKKLTLLVVSGDHLVELPTAL 302
+ LT LV++ + L+ LP ++
Sbjct: 288 CESLTELVLTENQLLTLPKSI 308
Score = 98.6 bits (244), Expect = 8e-21
Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 1/218 (0%)
Query: 89 SLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRI 148
SLP++ G + EL T LPDSL + L E + N I +P I ++
Sbjct: 142 SLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKD 201
Query: 149 LDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPF 208
L L NQ+S LP EIG LKNL L+V N L+ +P E+ +L L S NL L +P
Sbjct: 202 LWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNL-LETIPD 260
Query: 209 ELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLY 268
+ LK+++ + + N+ + +P V +L L ++ N L LP+ I +L++L +
Sbjct: 261 GIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNAD 320
Query: 269 KNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSS 306
+NKL LP + LT+ V + L +P + ++
Sbjct: 321 RNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQAT 358
Score = 87.8 bits (216), Expect = 1e-17
Identities = 68/230 (29%), Positives = 107/230 (46%), Gaps = 26/230 (11%)
Query: 105 LSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIG 164
LS LP + L E +S I IP I +A+++ D N ++ LP
Sbjct: 66 LSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFP 125
Query: 165 CLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVD---- 220
L+NL L+V L+S+P +G+ NL L+ NL L LP L+ L+++ +D
Sbjct: 126 ELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENL-LTYLPDSLTQLRRLEELDLGNN 184
Query: 221 -------------------ISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEE 261
+ N+ S +P + + NL LD+S N L LP++I L
Sbjct: 185 EIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTS 244
Query: 262 LQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTAL--CDSSTPL 309
L ++ +N L +P + LKKL++L V + L +LP A+ C+S T L
Sbjct: 245 LTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTEL 294
Score = 87.4 bits (215), Expect = 2e-17
Identities = 57/195 (29%), Positives = 97/195 (49%), Gaps = 1/195 (0%)
Query: 105 LSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIG 164
L ELP+ + LR+ +S+ IQ +P I F + LD+ +N+I +P I
Sbjct: 43 LDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESIS 102
Query: 165 CLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISAN 224
K L+ + N L +P + +NL L + ++ L LP + NL + +++ N
Sbjct: 103 FCKALQVADFSGNPLTRLPESFPELQNLTCLSVN-DISLQSLPENIGNLYNLASLELREN 161
Query: 225 KFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKK 284
+ +P + ++ L+ LD+ +N + +LP+ I L L+ L N+L+ LP + NLK
Sbjct: 162 LLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKN 221
Query: 285 LTLLVVSGDHLVELP 299
L L VS + L LP
Sbjct: 222 LLCLDVSENRLERLP 236
Score = 84.3 bits (207), Expect = 2e-16
Identities = 58/198 (29%), Positives = 99/198 (50%), Gaps = 2/198 (1%)
Query: 131 TLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCE 190
+L+ + + +++ L L NQ+ LP + L L++L + N ++ +PPE+ +
Sbjct: 23 SLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFM 82
Query: 191 NLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLT 250
L LD S N E+ E+P +S K + D S N + +P + NL L ++ +L
Sbjct: 83 QLVELDVSRN-EIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQ 141
Query: 251 DLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLK 310
LP++I L L S L +N LTYLP S+ L++L L + + + LP ++ + LK
Sbjct: 142 SLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESI-GALLHLK 200
Query: 311 FVSLMDNPIDNAQCEDGN 328
+ L N + E GN
Sbjct: 201 DLWLDGNQLSELPQEIGN 218
Score = 79.0 bits (193), Expect = 7e-15
Identities = 47/173 (27%), Positives = 87/173 (50%), Gaps = 1/173 (0%)
Query: 88 SSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMR 147
S LP++ G + ++S LP+ + T L + IS L++ IP I + +
Sbjct: 210 SELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLS 269
Query: 148 ILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELP 207
IL + +N+++ LP +G ++L EL + N L ++P +G + L L+ N +L+ LP
Sbjct: 270 ILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRN-KLVSLP 328
Query: 208 FELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLE 260
E+ +T + N+ + +P V + + L LD++ N L LP + L+
Sbjct: 329 KEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALK 381
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 99.4 bits (246), Expect = 5e-21
Identities = 59/210 (28%), Positives = 109/210 (51%), Gaps = 1/210 (0%)
Query: 90 LPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRIL 149
LPK + + +L +TE+P+ L++ + L+E+++ + IP +I + + L
Sbjct: 176 LPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYL 235
Query: 150 DLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFE 209
D+ KN I + I +NL++L + N L+ +P +G +N+ L N +LM LP
Sbjct: 236 DVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDEN-QLMYLPDS 294
Query: 210 LSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYK 269
+ L V +D S N+ ++P + +++NL+ N L LP +I + + L+
Sbjct: 295 IGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHS 354
Query: 270 NKLTYLPYSMLNLKKLTLLVVSGDHLVELP 299
NKL LP M +++KL ++ +S + L LP
Sbjct: 355 NKLETLPEEMGDMQKLKVINLSDNRLKNLP 384
Score = 92.8 bits (229), Expect = 4e-19
Identities = 57/201 (28%), Positives = 104/201 (51%), Gaps = 1/201 (0%)
Query: 102 VFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPA 161
+ E S ++LPD + +L + Y+++ ++ +P ++IL+L +NQ+ LP
Sbjct: 119 IVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPK 178
Query: 162 EIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDI 221
+ L L+ L++G N +P L L+ N L +P + +LKQ+T++D+
Sbjct: 179 TMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDAN-RLTFIPGFIGSLKQLTYLDV 237
Query: 222 SANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLN 281
S N V + NLQ L +SSN+L LP+ I L+ + + + +N+L YLP S+
Sbjct: 238 SKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGG 297
Query: 282 LKKLTLLVVSGDHLVELPTAL 302
L + L S + + LP+++
Sbjct: 298 LISVEELDCSFNEVEALPSSI 318
Score = 89.4 bits (220), Expect = 5e-18
Identities = 67/236 (28%), Positives = 109/236 (46%), Gaps = 24/236 (10%)
Query: 90 LPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRIL 149
LPK S L T LP S+ +LRE +S IQ P I+ + + I+
Sbjct: 61 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120
Query: 150 DLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFE 209
+ N IS LP L NL +L + +L+ +P G L+ L+ N +L LP
Sbjct: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELREN-QLKMLPKT 179
Query: 210 LSNLKQVTFVDISANKFSSVPICVLRMSNLQ-----------------------WLDISS 246
++ L Q+ +D+ +N+F+ VP + ++S L+ +LD+S
Sbjct: 180 MNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSK 239
Query: 247 NNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
NN+ + + I E LQ LL N L LP ++ +LK +T L + + L+ LP ++
Sbjct: 240 NNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSI 295
Score = 87.4 bits (215), Expect = 2e-17
Identities = 58/207 (28%), Positives = 108/207 (52%), Gaps = 24/207 (11%)
Query: 123 LREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSI 182
L E Y+ I+ +P + Q++ L LP N ++ LPA I L NL+EL+V N ++
Sbjct: 48 LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107
Query: 183 PPELGDCENLERLDCSGN------------LELMEL----------PFELSNLKQVTFVD 220
P + +C+ L ++ S N L L +L P L ++ ++
Sbjct: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILE 167
Query: 221 ISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSML 280
+ N+ +P + R++ L+ LD+ SN T++P+ +++L L+ F + N+LT++P +
Sbjct: 168 LRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIG 227
Query: 281 NLKKLTLLVVSGDH--LVELPTALCDS 305
+LK+LT L VS ++ +VE + C++
Sbjct: 228 SLKQLTYLDVSKNNIEMVEEGISTCEN 254
Score = 76.3 bits (186), Expect = 4e-14
Identities = 54/175 (30%), Positives = 89/175 (50%), Gaps = 2/175 (1%)
Query: 129 SNTLIQIIPTYIQLFQ-AMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELG 187
S+ ++ +P I F+ + L L NQI LP ++ ++L +L++ N L ++P +
Sbjct: 30 SHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIA 89
Query: 188 DCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSN 247
+ NL LD S N + E P + N K +T V+ S N S +P ++ NL L ++
Sbjct: 90 NLINLRELDVSKN-GIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDA 148
Query: 248 NLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
L LP + RL +LQ L +N+L LP +M L +L L + + E+P L
Sbjct: 149 FLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
Score = 75.9 bits (185), Expect = 6e-14
Identities = 46/186 (24%), Positives = 96/186 (51%), Gaps = 1/186 (0%)
Query: 86 RQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQA 145
R + +P G ++S + + + + +L++ +S+ +Q +P I +
Sbjct: 218 RLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKN 277
Query: 146 MRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELME 205
+ L + +NQ+ +LP IG L +++EL+ FN ++++P +G NL N L +
Sbjct: 278 ITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNY-LQQ 336
Query: 206 LPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSF 265
LP E+ + K +T + + +NK ++P + M L+ +++S N L +LP +L++L +
Sbjct: 337 LPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAM 396
Query: 266 LLYKNK 271
L N+
Sbjct: 397 WLSDNQ 402
Score = 32.7 bits (73), Expect = 0.54
Identities = 17/96 (17%), Positives = 45/96 (46%)
Query: 89 SLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRI 148
+LP G+ ++ F + +LP + ++ ++ + ++ +P + Q +++
Sbjct: 313 ALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKV 372
Query: 149 LDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPP 184
++L N++ +LP L+ L + + N K + P
Sbjct: 373 INLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIP 408
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 99.4 bits (246), Expect = 5e-21
Identities = 59/210 (28%), Positives = 109/210 (51%), Gaps = 1/210 (0%)
Query: 90 LPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRIL 149
LPK + + +L +TE+P+ L++ + L+E+++ + IP +I + + L
Sbjct: 176 LPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYL 235
Query: 150 DLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFE 209
D+ KN I + I +NL++L + N L+ +P +G +N+ L N +LM LP
Sbjct: 236 DVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDEN-QLMYLPDS 294
Query: 210 LSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYK 269
+ L V +D S N+ ++P + +++NL+ N L LP +I + + L+
Sbjct: 295 IGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHS 354
Query: 270 NKLTYLPYSMLNLKKLTLLVVSGDHLVELP 299
NKL LP M +++KL ++ +S + L LP
Sbjct: 355 NKLETLPEEMGDMQKLKVINLSDNRLKNLP 384
Score = 92.8 bits (229), Expect = 4e-19
Identities = 57/201 (28%), Positives = 104/201 (51%), Gaps = 1/201 (0%)
Query: 102 VFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPA 161
+ E S ++LPD + +L + Y+++ ++ +P ++IL+L +NQ+ LP
Sbjct: 119 IVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPK 178
Query: 162 EIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDI 221
+ L L+ L++G N +P L L+ N L +P + +LKQ+T++D+
Sbjct: 179 TMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDAN-RLTFIPGFIGSLKQLTYLDV 237
Query: 222 SANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLN 281
S N V + NLQ L +SSN+L LP+ I L+ + + + +N+L YLP S+
Sbjct: 238 SKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGG 297
Query: 282 LKKLTLLVVSGDHLVELPTAL 302
L + L S + + LP+++
Sbjct: 298 LISVEELDCSFNEVEALPSSI 318
Score = 89.4 bits (220), Expect = 5e-18
Identities = 67/236 (28%), Positives = 109/236 (46%), Gaps = 24/236 (10%)
Query: 90 LPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRIL 149
LPK S L T LP S+ +LRE +S IQ P I+ + + I+
Sbjct: 61 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120
Query: 150 DLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFE 209
+ N IS LP L NL +L + +L+ +P G L+ L+ N +L LP
Sbjct: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELREN-QLKMLPKT 179
Query: 210 LSNLKQVTFVDISANKFSSVPICVLRMSNLQ-----------------------WLDISS 246
++ L Q+ +D+ +N+F+ VP + ++S L+ +LD+S
Sbjct: 180 MNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSK 239
Query: 247 NNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
NN+ + + I E LQ LL N L LP ++ +LK +T L + + L+ LP ++
Sbjct: 240 NNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSI 295
Score = 87.4 bits (215), Expect = 2e-17
Identities = 58/207 (28%), Positives = 108/207 (52%), Gaps = 24/207 (11%)
Query: 123 LREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSI 182
L E Y+ I+ +P + Q++ L LP N ++ LPA I L NL+EL+V N ++
Sbjct: 48 LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107
Query: 183 PPELGDCENLERLDCSGN------------LELMEL----------PFELSNLKQVTFVD 220
P + +C+ L ++ S N L L +L P L ++ ++
Sbjct: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILE 167
Query: 221 ISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSML 280
+ N+ +P + R++ L+ LD+ SN T++P+ +++L L+ F + N+LT++P +
Sbjct: 168 LRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIG 227
Query: 281 NLKKLTLLVVSGDH--LVELPTALCDS 305
+LK+LT L VS ++ +VE + C++
Sbjct: 228 SLKQLTYLDVSKNNIEMVEEGISTCEN 254
Score = 76.3 bits (186), Expect = 4e-14
Identities = 54/175 (30%), Positives = 89/175 (50%), Gaps = 2/175 (1%)
Query: 129 SNTLIQIIPTYIQLFQ-AMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELG 187
S+ ++ +P I F+ + L L NQI LP ++ ++L +L++ N L ++P +
Sbjct: 30 SHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIA 89
Query: 188 DCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSN 247
+ NL LD S N + E P + N K +T V+ S N S +P ++ NL L ++
Sbjct: 90 NLINLRELDVSKN-GIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDA 148
Query: 248 NLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
L LP + RL +LQ L +N+L LP +M L +L L + + E+P L
Sbjct: 149 FLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
Score = 75.9 bits (185), Expect = 6e-14
Identities = 46/186 (24%), Positives = 96/186 (51%), Gaps = 1/186 (0%)
Query: 86 RQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQA 145
R + +P G ++S + + + + +L++ +S+ +Q +P I +
Sbjct: 218 RLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKN 277
Query: 146 MRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELME 205
+ L + +NQ+ +LP IG L +++EL+ FN ++++P +G NL N L +
Sbjct: 278 ITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNY-LQQ 336
Query: 206 LPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSF 265
LP E+ + K +T + + +NK ++P + M L+ +++S N L +LP +L++L +
Sbjct: 337 LPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAM 396
Query: 266 LLYKNK 271
L N+
Sbjct: 397 WLSDNQ 402
Score = 32.7 bits (73), Expect = 0.54
Identities = 17/96 (17%), Positives = 45/96 (46%)
Query: 89 SLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRI 148
+LP G+ ++ F + +LP + ++ ++ + ++ +P + Q +++
Sbjct: 313 ALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKV 372
Query: 149 LDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPP 184
++L N++ +LP L+ L + + N K + P
Sbjct: 373 INLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIP 408
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 99.0 bits (245), Expect = 6e-21
Identities = 80/263 (30%), Positives = 136/263 (51%), Gaps = 18/263 (6%)
Query: 65 KNGFIDTSVRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLR 124
K+G ++ S R L ++ + +P++ + S F + W EQT L
Sbjct: 37 KSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLS---FGATERWW--------EQTDLT 85
Query: 125 EWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPP 184
+ ISN +Q + ++L A+ +LD+ NQ++ LP+ I L+NL++LNV N LK +P
Sbjct: 86 KLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPE 145
Query: 185 ELGDCENLERLDCSGN-LELMELPFE-LSNLKQVTFVDISANKFSSVPICVLRMSNLQWL 242
E+ + NL+ L N L + FE LSNL+ +D+S N ++VP +S+L L
Sbjct: 146 EITNLRNLKCLYLQHNELTCISEGFEQLSNLED---LDLSNNHLTTVPASFSSLSSLVRL 202
Query: 243 DISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
++SSN L LP +I+R++ L+ N L +P + ++ L LL + + L LP
Sbjct: 203 NLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE-- 260
Query: 303 CDSSTPLKFVSLMDNPIDNAQCE 325
S + LK + + +N I+ + E
Sbjct: 261 FPSCSLLKELHVGENQIEMLEAE 283
Score = 77.0 bits (188), Expect = 2e-14
Identities = 53/216 (24%), Positives = 104/216 (48%), Gaps = 26/216 (12%)
Query: 69 IDTSVRLLDKIERNTLTRQSS--LPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREW 126
+ +++R L+ +++ ++ LP++ + L T + + ++ ++L +
Sbjct: 120 LPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDL 179
Query: 127 YISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPEL 186
+SN + +P ++ L+L N++ LPAEI +K LK L+ N L++IPPEL
Sbjct: 180 DLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPEL 239
Query: 187 GDCENLERL--------------DCS---------GNLELMELPFELSNLKQVTFVDISA 223
E+LE L CS +E++E L +L + +D+
Sbjct: 240 AGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAE-HLKHLNSILVLDLRD 298
Query: 224 NKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRL 259
NK SVP ++ + +L+ LD+S+N+++ LP + L
Sbjct: 299 NKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL 334
Score = 57.8 bits (138), Expect = 2e-08
Identities = 45/160 (28%), Positives = 81/160 (50%), Gaps = 2/160 (1%)
Query: 112 ELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKE 171
E+ D++K + N L +I ++L + + +DL N++S + E+ L+ L
Sbjct: 417 EVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTF 476
Query: 172 LNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSV-P 230
L++ N+L S+P E+ L+ ++ S N M LP L + + + IS N+ SV P
Sbjct: 477 LDLRNNFLNSLPEEMESLVRLQTINLSFNRFKM-LPEVLYRIFTLETILISNNQVGSVDP 535
Query: 231 ICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKN 270
+ M NL LD+ +N+L +P ++ L++ LL N
Sbjct: 536 QKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
Score = 53.1 bits (126), Expect = 4e-07
Identities = 51/180 (28%), Positives = 87/180 (48%), Gaps = 13/180 (7%)
Query: 159 LPAE----IGCLKNLKELNVGFNYLKSIPPELGDCEN---LERLDCSGNLELMELPFELS 211
LP+E I + LK L+ IP E+ D + ++ S N +L E+P +
Sbjct: 387 LPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKN-QLCEIPKRMV 445
Query: 212 NLKQ-VTFVDISANK--FSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLY 268
LK+ V+ VD+S NK F S+ +CVL+ L +LD+ +N L LP++++ L LQ+ L
Sbjct: 446 ELKEMVSDVDLSFNKLSFISLELCVLQ--KLTFLDLRNNFLNSLPEEMESLVRLQTINLS 503
Query: 269 KNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDNPIDNAQCEDGN 328
N+ LP + + L +++S + + + L + L +N + E GN
Sbjct: 504 FNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGN 563
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 98.2 bits (243), Expect = 1e-20
Identities = 65/227 (28%), Positives = 116/227 (51%), Gaps = 5/227 (2%)
Query: 73 VRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTL 132
+R+L+ E + T LPK K + +L + ELP+ L + +LRE ++ N
Sbjct: 163 LRILELRENHLKT----LPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNA 218
Query: 133 IQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENL 192
+Q++P I + + LD+ KN+I + +I + L++L + N L+ +P +G + L
Sbjct: 219 LQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKL 278
Query: 193 ERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDL 252
L N +L LP + NL + D S N+ S+P + + +L+ L + N L +L
Sbjct: 279 TTLKVDDN-QLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPEL 337
Query: 253 PQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELP 299
P++I + + L NKL +LP + ++KL +L +S + L LP
Sbjct: 338 PREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLP 384
Score = 94.4 bits (233), Expect = 2e-19
Identities = 65/232 (28%), Positives = 113/232 (48%), Gaps = 2/232 (0%)
Query: 90 LPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRIL 149
LP + G+ + EL H LP S+ + L + N +P + Q +R L
Sbjct: 153 LPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLREL 212
Query: 150 DLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFE 209
+ N + LP IG LK L L++ N ++++ ++ CE LE L S N+ L +LP
Sbjct: 213 WMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNM-LQQLPDS 271
Query: 210 LSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYK 269
+ LK++T + + N+ + +P + +S L+ D S N L LP I L L++ + +
Sbjct: 272 IGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDE 331
Query: 270 NKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDNPIDN 321
N L LP + + K +T++ + + L LP + L+ ++L DN + N
Sbjct: 332 NFLPELPREIGSCKNVTVMSLRSNKLEFLPEEI-GQMQKLRVLNLSDNRLKN 382
Score = 90.9 bits (224), Expect = 2e-18
Identities = 58/201 (28%), Positives = 101/201 (50%), Gaps = 1/201 (0%)
Query: 102 VFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPA 161
+ E S ++LPD + +L + Y+++ ++ +P +RIL+L +N + LP
Sbjct: 119 IIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPK 178
Query: 162 EIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDI 221
+ L L+ L++G N +P L +NL L N L LP + LK + ++D+
Sbjct: 179 SMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNA-LQVLPGSIGKLKMLVYLDM 237
Query: 222 SANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLN 281
S N+ +V + + L+ L +SSN L LP I L++L + + N+LT LP ++ N
Sbjct: 238 SKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGN 297
Query: 282 LKKLTLLVVSGDHLVELPTAL 302
L L S + L LP+ +
Sbjct: 298 LSLLEEFDCSCNELESLPSTI 318
Score = 84.3 bits (207), Expect = 2e-16
Identities = 64/215 (29%), Positives = 98/215 (45%), Gaps = 24/215 (11%)
Query: 111 TELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLP---------- 160
+ LP ++ +L+E IS +Q P I+ + + I++ N IS LP
Sbjct: 82 SNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLT 141
Query: 161 -------------AEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELP 207
A G L L+ L + N+LK++P + LERLD GN E ELP
Sbjct: 142 QLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDL-GNNEFGELP 200
Query: 208 FELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLL 267
L ++ + + + N +P + ++ L +LD+S N + + DI E L+ LL
Sbjct: 201 EVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLL 260
Query: 268 YKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
N L LP S+ LKKLT L V + L LP +
Sbjct: 261 SSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTI 295
Score = 80.9 bits (198), Expect = 2e-15
Identities = 57/217 (26%), Positives = 105/217 (48%), Gaps = 24/217 (11%)
Query: 123 LREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSI 182
L E Y+ I+ +P + QA+R L +P N +S+LP I L NLKEL++ N ++
Sbjct: 48 LEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEF 107
Query: 183 PPELGDCENLERLDCSGN------------LELME----------LPFELSNLKQVTFVD 220
P + C+ L ++ S N L L + LP L ++ ++
Sbjct: 108 PENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILE 167
Query: 221 ISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSML 280
+ N ++P + +++ L+ LD+ +N +LP+ +D+++ L+ + N L LP S+
Sbjct: 168 LRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIG 227
Query: 281 NLKKLTLLVVSGDHL--VELPTALCDSSTPLKFVSLM 315
LK L L +S + + V++ + C++ L S M
Sbjct: 228 KLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNM 264
Score = 71.2 bits (173), Expect = 1e-12
Identities = 53/175 (30%), Positives = 87/175 (49%), Gaps = 2/175 (1%)
Query: 129 SNTLIQIIPTYIQLFQ-AMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELG 187
S+ +Q +P + F+ + L L NQI LP ++ + L++L++ N L ++P +
Sbjct: 30 SHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIA 89
Query: 188 DCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSN 247
NL+ LD S N + E P + K +T ++ S N S +P ++ NL L ++
Sbjct: 90 SLVNLKELDISKN-GVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDA 148
Query: 248 NLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
L LP + RL +L+ L +N L LP SM L +L L + + ELP L
Sbjct: 149 FLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVL 203
Score = 48.1 bits (113), Expect = 1e-05
Identities = 35/132 (26%), Positives = 58/132 (43%), Gaps = 3/132 (2%)
Query: 78 KIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIP 137
K++ N LT LP G S F+ S LP ++ LR + + +P
Sbjct: 282 KVDDNQLTM---LPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELP 338
Query: 138 TYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDC 197
I + + ++ L N++ LP EIG ++ L+ LN+ N LK++P + L L
Sbjct: 339 REIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWL 398
Query: 198 SGNLELMELPFE 209
S N +P +
Sbjct: 399 SDNQSKALIPLQ 410
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 92.0 bits (227), Expect = 7e-19
Identities = 79/323 (24%), Positives = 147/323 (45%), Gaps = 34/323 (10%)
Query: 34 RLEKSALEKIKEEWNFVAECRRKGIPQAVYCKNGF--IDTSVRLLDKIERNTL--TRQSS 89
R + S E IKE + +CR + + K + +S++ L ++ L + S
Sbjct: 82 RKKSSNAEVIKE----LNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQS 137
Query: 90 LPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMR-- 147
LP + G + LS T LPDSL LR + + ++ IP+ + ++
Sbjct: 138 LPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTL 197
Query: 148 ---------------------ILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPEL 186
+L + +N+I LPAEIG L NL L+V N L+ +P E+
Sbjct: 198 YLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEI 257
Query: 187 GDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISS 246
G+C + LD N EL++LP + NL ++ + + N+ S++P + + S L+ L++ +
Sbjct: 258 GNCTQITNLDLQHN-ELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLEN 316
Query: 247 NNLTDLPQD-IDRLEELQSFLLYKNKLTYLPY-SMLNLKKLTLLVVSGDHLVELPTALCD 304
NN++ LP+ + L +L S L +N P + L + + + ++P +
Sbjct: 317 NNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFS 376
Query: 305 SSTPLKFVSLMDNPIDNAQCEDG 327
+ L +++ DN + + + G
Sbjct: 377 RAKVLSKLNMKDNQLTSLPLDFG 399
Score = 85.5 bits (210), Expect = 7e-17
Identities = 73/265 (27%), Positives = 123/265 (46%), Gaps = 33/265 (12%)
Query: 86 RQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQ-THLREWYISNTLIQIIPT------ 138
R S++P+ K S+ L + + LP+SL L ++ Q+ P
Sbjct: 295 RLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQF 354
Query: 139 ---YIQLFQAMRI----------------LDLPKNQISHLPAEIGCLKNLKELNVGFNYL 179
Y + RI L++ NQ++ LP + G ++ ELN+ N L
Sbjct: 355 STIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQL 414
Query: 180 KSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNL 239
IP ++ +LE L S NL L +LP L NL+++ +D+ NK S+P + + +L
Sbjct: 415 TKIPEDVSGLVSLEVLILSNNL-LKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDL 473
Query: 240 QWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGD---HLV 296
Q L +++N LT LP+ I L L L +N LT+LP + L+ L L ++ + H +
Sbjct: 474 QKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSL 533
Query: 297 ELPTALCDSSTPLKFVSLMDNPIDN 321
ALC + L +S+ + P+ +
Sbjct: 534 PFELALC---SKLSIMSIENCPLSH 555
Score = 75.9 bits (185), Expect = 6e-14
Identities = 51/153 (33%), Positives = 75/153 (49%), Gaps = 1/153 (0%)
Query: 79 IERNTLTRQ-SSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIP 137
+E N T Q + +P+D S V LS +LP L LRE + ++ +P
Sbjct: 405 VELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLP 464
Query: 138 TYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDC 197
I + ++ L L NQ++ LP IG L NL L +G N L +P E+G ENLE L
Sbjct: 465 NEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYL 524
Query: 198 SGNLELMELPFELSNLKQVTFVDISANKFSSVP 230
+ N L LPFEL+ +++ + I S +P
Sbjct: 525 NDNPNLHSLPFELALCSKLSIMSIENCPLSHLP 557
Score = 71.2 bits (173), Expect = 1e-12
Identities = 51/170 (30%), Positives = 86/170 (50%), Gaps = 2/170 (1%)
Query: 88 SSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMR 147
+SLP D G +S L+ T++P+ + L +SN L++ +P + + +R
Sbjct: 392 TSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLR 451
Query: 148 ILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELP 207
LDL +N++ LP EI LK+L++L + N L ++P +G NL L NL L LP
Sbjct: 452 ELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENL-LTHLP 510
Query: 208 FELSNLKQVTFVDISAN-KFSSVPICVLRMSNLQWLDISSNNLTDLPQDI 256
E+ L+ + + ++ N S+P + S L + I + L+ LP I
Sbjct: 511 EEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQI 560
Score = 69.7 bits (169), Expect = 4e-12
Identities = 59/265 (22%), Positives = 112/265 (42%), Gaps = 48/265 (18%)
Query: 86 RQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQA 145
R +++ KD S + + +LP + E +L +++ ++ +P I
Sbjct: 203 RITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQ 262
Query: 146 MRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNL---- 201
+ LDL N++ LP IG L +L L + +N L +IP L C LE L+ N
Sbjct: 263 ITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTL 322
Query: 202 -------------------------------------------ELMELPFEL-SNLKQVT 217
+ ++PF + S K ++
Sbjct: 323 PESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLS 382
Query: 218 FVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPY 277
+++ N+ +S+P+ +++ L++++N LT +P+D+ L L+ +L N L LP+
Sbjct: 383 KLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPH 442
Query: 278 SMLNLKKLTLLVVSGDHLVELPTAL 302
+ NL+KL L + + L LP +
Sbjct: 443 GLGNLRKLRELDLEENKLESLPNEI 467
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 90.9 bits (224), Expect = 2e-18
Identities = 66/231 (28%), Positives = 111/231 (48%), Gaps = 2/231 (0%)
Query: 89 SLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRI 148
+LP G + ++S LPDSL + LR + + + P + A+
Sbjct: 149 ALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEE 208
Query: 149 LDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPF 208
LD+ N++ LP +I L+ LK L + L ++P + +LE L N L LP
Sbjct: 209 LDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNN-GLQALPA 267
Query: 209 ELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLY 268
+ S L+++ +++S+N F P +L ++ L+ L +S N LT +P I L L + L
Sbjct: 268 QFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLD 327
Query: 269 KNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDNPI 319
N++ YLP S++ L L LV+ G+ + LP S + + DNP+
Sbjct: 328 NNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSR-VGLWKIKDNPL 377
Score = 88.2 bits (217), Expect = 1e-17
Identities = 62/189 (32%), Positives = 99/189 (52%), Gaps = 3/189 (1%)
Query: 130 NTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEI-GCLKNLKELNVGFNYLKSIPPELGD 188
N ++ P +L + LD+ N+++ L AE+ L+ L++LN+ N L ++P +LG
Sbjct: 97 NRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGA 156
Query: 189 CENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNN 248
+LE LD S N L LP LS L ++ +D+ N+ ++ P +L++ L+ LD+SSN
Sbjct: 157 LAHLEELDVSFN-RLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNR 215
Query: 249 LTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTP 308
L LP+DI L L+ L +L LP L L L++ + L LP A
Sbjct: 216 LRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALP-AQFSCLQR 274
Query: 309 LKFVSLMDN 317
LK ++L N
Sbjct: 275 LKMLNLSSN 283
Score = 75.1 bits (183), Expect = 9e-14
Identities = 57/226 (25%), Positives = 103/226 (45%), Gaps = 1/226 (0%)
Query: 83 TLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQL 142
+ R + LP S ++ T P L + L E +S+ ++ +P I
Sbjct: 166 SFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISA 225
Query: 143 FQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLE 202
+A++IL L ++ LPA L +L+ L + N L+++P + + L+ L+ S NL
Sbjct: 226 LRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNL- 284
Query: 203 LMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEEL 262
E P L L + + +S N+ +SVP + + L L + +N + LP I L L
Sbjct: 285 FEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGL 344
Query: 263 QSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTP 308
+ +L N++ LP L ++ L + + L++ P +C P
Sbjct: 345 EELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIP 390
Score = 73.9 bits (180), Expect = 2e-13
Identities = 52/164 (31%), Positives = 89/164 (54%), Gaps = 7/164 (4%)
Query: 145 AMRILDLPKNQISHLP---AEIGCLKNLKELNVGFNYLKSIPPELGDC-ENLERLDCSGN 200
++R+L L +N+ + LP AE+G +L EL+V N L ++ E+ L +L+ S N
Sbjct: 88 SLRVLVLRRNRFARLPPAVAELG--HHLTELDVSHNRLTALGAEVVSALRELRKLNLSHN 145
Query: 201 LELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLE 260
+L LP +L L + +D+S N+ + +P + +S L+ LD+ N LT P+ + +L
Sbjct: 146 -QLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLV 204
Query: 261 ELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCD 304
L+ + N+L LP + L+ L +L +SG L LP C+
Sbjct: 205 ALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCE 248
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 89.4 bits (220), Expect = 5e-18
Identities = 69/236 (29%), Positives = 114/236 (48%), Gaps = 2/236 (0%)
Query: 71 TSVRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISN 130
T +R L + N ++ Q+ LP D G ++ EL LP SL L + +
Sbjct: 125 TQLRSLAHLALNDVSLQA-LPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGG 183
Query: 131 TLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCE 190
++++P + +R L L +NQ+S LP E+G L+ L L+V N L+ +P ELG
Sbjct: 184 NDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLV 243
Query: 191 NLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLT 250
L L S NL L LP + LKQ++ + + N+ V + NL L ++ N L
Sbjct: 244 LLTDLLLSQNL-LRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLM 302
Query: 251 DLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSS 306
LP+ + +L +L + + +N L LP + L++L + + L LP L ++
Sbjct: 303 ALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTT 358
Score = 83.6 bits (205), Expect = 3e-16
Identities = 76/275 (27%), Positives = 120/275 (43%), Gaps = 32/275 (11%)
Query: 53 CRRKGIPQAVYCKNGFIDTSVRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTE 112
C + +P+ +Y + ++ + ++ N L LPK + + LS
Sbjct: 22 CSLQAVPEEIYRYSRSLEELL-----LDANQLRE---LPKPFFRLLNLRKLGLSDNEIQR 73
Query: 113 LPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLP------------ 160
LP + L E +S I IP I+ +A+ I D N +S LP
Sbjct: 74 LPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHL 133
Query: 161 -----------AEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFE 209
++G L NL L + N LKS+P L LE+LD GN +L LP
Sbjct: 134 ALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGN-DLEVLPDT 192
Query: 210 LSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYK 269
L L + + + N+ S++P + + L LD+S N L +LP ++ L L LL +
Sbjct: 193 LGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQ 252
Query: 270 NKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCD 304
N L LP + LK+L++L V + L E+ A+ D
Sbjct: 253 NLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGD 287
Score = 55.5 bits (132), Expect = 8e-08
Identities = 39/141 (27%), Positives = 67/141 (47%), Gaps = 3/141 (2%)
Query: 73 VRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTL 132
V L D + L R+ LP G+ + ++ E+ +++ + +L E ++ L
Sbjct: 243 VLLTDLLLSQNLLRR--LPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENL 300
Query: 133 IQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENL 192
+ +P + + L++ +N + LP EIG L L++ N L +PPEL L
Sbjct: 301 LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTEL 360
Query: 193 ERLDCSGNLELMELPFELSNL 213
LD +GN L LPF L++L
Sbjct: 361 HVLDVAGN-RLQSLPFALTHL 380
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 89.4 bits (220), Expect = 5e-18
Identities = 69/236 (29%), Positives = 114/236 (48%), Gaps = 2/236 (0%)
Query: 71 TSVRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISN 130
T +R L + N ++ Q+ LP D G ++ EL LP SL L + +
Sbjct: 125 TQLRSLAHLALNDVSLQA-LPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGG 183
Query: 131 TLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCE 190
++++P + +R L L +NQ+S LP E+G L+ L L+V N L+ +P ELG
Sbjct: 184 NDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLV 243
Query: 191 NLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLT 250
L L S NL L LP + LKQ++ + + N+ V + NL L ++ N L
Sbjct: 244 LLTDLLLSQNL-LRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLM 302
Query: 251 DLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSS 306
LP+ + +L +L + + +N L LP + L++L + + L LP L ++
Sbjct: 303 ALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTT 358
Score = 83.6 bits (205), Expect = 3e-16
Identities = 76/275 (27%), Positives = 120/275 (43%), Gaps = 32/275 (11%)
Query: 53 CRRKGIPQAVYCKNGFIDTSVRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTE 112
C + +P+ +Y + ++ + ++ N L LPK + + LS
Sbjct: 22 CSLQAVPEEIYRYSRSLEELL-----LDANQLRE---LPKPFFRLLNLRKLGLSDNEIQR 73
Query: 113 LPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLP------------ 160
LP + L E +S I IP I+ +A+ I D N +S LP
Sbjct: 74 LPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHL 133
Query: 161 -----------AEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFE 209
++G L NL L + N LKS+P L LE+LD GN +L LP
Sbjct: 134 ALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGN-DLEVLPDT 192
Query: 210 LSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYK 269
L L + + + N+ S++P + + L LD+S N L +LP ++ L L LL +
Sbjct: 193 LGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQ 252
Query: 270 NKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCD 304
N L LP + LK+L++L V + L E+ A+ D
Sbjct: 253 NLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGD 287
Score = 55.5 bits (132), Expect = 8e-08
Identities = 39/141 (27%), Positives = 67/141 (47%), Gaps = 3/141 (2%)
Query: 73 VRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTL 132
V L D + L R+ LP G+ + ++ E+ +++ + +L E ++ L
Sbjct: 243 VLLTDLLLSQNLLRR--LPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENL 300
Query: 133 IQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENL 192
+ +P + + L++ +N + LP EIG L L++ N L +PPEL L
Sbjct: 301 LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTEL 360
Query: 193 ERLDCSGNLELMELPFELSNL 213
LD +GN L LPF L++L
Sbjct: 361 HVLDVAGN-RLQSLPFALTHL 380
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 86.3 bits (212), Expect = 4e-17
Identities = 51/163 (31%), Positives = 86/163 (52%), Gaps = 1/163 (0%)
Query: 121 THLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLK 180
+H+ + +S+ + ++P I + + +L+ NQI LP +I L+ LK LN+G N L
Sbjct: 40 SHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLN 99
Query: 181 SIPPELGDCENLERLDCS-GNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNL 239
++P G LE LD + NL LP L + + +S N F +P + +++ L
Sbjct: 100 TLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKL 159
Query: 240 QWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNL 282
Q L + N+L LP++I L +L+ + N+LT LP + NL
Sbjct: 160 QILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 202
Score = 66.2 bits (160), Expect = 4e-11
Identities = 46/165 (27%), Positives = 88/165 (53%), Gaps = 4/165 (2%)
Query: 166 LKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANK 225
L ++ +L + N L +PP + + +NLE L+ N ++ ELP ++S+L+++ +++ N+
Sbjct: 39 LSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNN-QIEELPTQISSLQKLKHLNLGMNR 97
Query: 226 FSSVPICVLRMSNLQWLDISSNNLTD--LPQDIDRLEELQSFLLYKNKLTYLPYSMLNLK 283
+++P + L+ LD++ NNL++ LP + L L++ L N LP + L
Sbjct: 98 LNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLT 157
Query: 284 KLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDNPIDNAQCEDGN 328
KL +L + + L+ LP + T LK + + N + E GN
Sbjct: 158 KLQILSLRDNDLISLPKEI-GELTQLKELHIQGNRLTVLPPELGN 201
Score = 61.6 bits (148), Expect = 1e-09
Identities = 42/126 (33%), Positives = 67/126 (53%), Gaps = 4/126 (3%)
Query: 69 IDTSVRLLDKIERNTL--TRQSSLPKDRGKRSSAFVFELSGEHWTE--LPDSLKEQTHLR 124
+ T + L K++ L R ++LP+ G + V +L+ + +E LP + T LR
Sbjct: 78 LPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLR 137
Query: 125 EWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPP 184
Y+S+ +I+P I ++IL L N + LP EIG L LKEL++ N L +PP
Sbjct: 138 ALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPP 197
Query: 185 ELGDCE 190
ELG+ +
Sbjct: 198 ELGNLD 203
Score = 49.3 bits (116), Expect = 6e-06
Identities = 32/121 (26%), Positives = 55/121 (45%), Gaps = 3/121 (2%)
Query: 112 ELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISH--LPAEIGCLKNL 169
ELP + L+ + + +P A+ +LDL N +S LP L L
Sbjct: 77 ELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTL 136
Query: 170 KELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSV 229
+ L + N + +PP++G L+ L N +L+ LP E+ L Q+ + I N+ + +
Sbjct: 137 RALYLSDNDFEILPPDIGKLTKLQILSLRDN-DLISLPKEIGELTQLKELHIQGNRLTVL 195
Query: 230 P 230
P
Sbjct: 196 P 196
Score = 45.8 bits (107), Expect = 6e-05
Identities = 27/88 (30%), Positives = 48/88 (54%)
Query: 210 LSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYK 269
L L +T + +S NK + VP + + NL+ L+ +N + +LP I L++L+ L
Sbjct: 36 LFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGM 95
Query: 270 NKLTYLPYSMLNLKKLTLLVVSGDHLVE 297
N+L LP +L L +L ++ ++L E
Sbjct: 96 NRLNTLPRGFGSLPALEVLDLTYNNLSE 123
Score = 32.3 bits (72), Expect = 0.70
Identities = 24/88 (27%), Positives = 44/88 (50%), Gaps = 3/88 (3%)
Query: 235 RMSNLQWLDISSNNLTDL--PQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSG 292
R N +D+S ++++ + L + +L NKLT +P ++ LK L +L
Sbjct: 13 REKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFN 72
Query: 293 DHLVELPTALCDSSTPLKFVSLMDNPID 320
+ + ELPT + S LK ++L N ++
Sbjct: 73 NQIEELPTQI-SSLQKLKHLNLGMNRLN 99
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 85.5 bits (210), Expect = 7e-17
Identities = 63/220 (28%), Positives = 111/220 (50%), Gaps = 7/220 (3%)
Query: 104 ELSGEHWTELPDSLKEQTHLREWYIS-NTLIQIIPTYIQLFQAMRILDLPKNQI--SHLP 160
+LS LP ++ HL+ ++ N L+ + A++ L L Q S+LP
Sbjct: 157 DLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLP 216
Query: 161 AEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVD 220
+ L NL ++++ N L +P L +L RL+ S N ++ EL + V ++
Sbjct: 217 TSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSN-QITELSLCIDQWVHVETLN 275
Query: 221 ISANKFSSVPICVLRMSNLQWLDISSNNLT--DLPQDIDRLEELQSFLLYKNKLTYLPYS 278
+S N+ +S+P + ++S L+ L ++SN L LP I +L L+ F+ N L +P S
Sbjct: 276 LSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPES 335
Query: 279 MLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDNP 318
+ KL LV++ +HLV LP A+ T ++ + + +NP
Sbjct: 336 LCRCPKLRKLVLNKNHLVTLPEAI-HFLTEIEVLDVRENP 374
Score = 79.0 bits (193), Expect = 7e-15
Identities = 61/220 (27%), Positives = 106/220 (48%), Gaps = 3/220 (1%)
Query: 79 IERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPT 138
+ R + S +P D K V +LS TE P L+ ++ +S+ I IP
Sbjct: 85 VARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPN 144
Query: 139 YIQL-FQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFN-YLKSIPPELGDCENLERLD 196
+ + + LDL +N++ LP ++ L +L+ L + N L + +L L+ L
Sbjct: 145 QLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLH 204
Query: 197 CSGNLELME-LPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQD 255
LP L L + VD+S N + VP C+ + +L+ L++SSN +T+L
Sbjct: 205 LRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLC 264
Query: 256 IDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHL 295
ID+ +++ L +N+LT LP ++ L KL L ++ + L
Sbjct: 265 IDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKL 304
Score = 60.5 bits (145), Expect = 2e-09
Identities = 42/171 (24%), Positives = 90/171 (52%), Gaps = 3/171 (1%)
Query: 136 IPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERL 195
+PT ++ + +DL N ++ +P + L +L+ LN+ N + + + ++E L
Sbjct: 215 LPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETL 274
Query: 196 DCSGNLELMELPFELSNLKQVTFVDISANK--FSSVPICVLRMSNLQWLDISSNNLTDLP 253
+ S N +L LP + L ++ + +++NK F +P + +++NL+ ++NNL +P
Sbjct: 275 NLSRN-QLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVP 333
Query: 254 QDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCD 304
+ + R +L+ +L KN L LP ++ L ++ +L V + + +P D
Sbjct: 334 ESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPAD 384
Score = 49.7 bits (117), Expect = 4e-06
Identities = 44/178 (24%), Positives = 78/178 (43%), Gaps = 24/178 (13%)
Query: 146 MRILDLPKNQIS--HLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLEL 203
+R +DL N + P + + +L+ L + L +P EL + LE L S N L
Sbjct: 10 VRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHN-NL 68
Query: 204 MELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQ 263
L ELS+L + + AN + + +P DI +L++L
Sbjct: 69 TTLHGELSSLPSLRAIVARANSLKN---------------------SGVPDDIFKLDDLS 107
Query: 264 SFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDNPIDN 321
L N+LT P + N K + +L +S + + +P L + T L ++ L +N +++
Sbjct: 108 VLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLES 165
Score = 37.0 bits (84), Expect = 0.028
Identities = 32/112 (28%), Positives = 52/112 (46%), Gaps = 5/112 (4%)
Query: 79 IERNTLTRQSSLPKDRGKRSSAFVFELSGEH--WTELPDSLKEQTHLREWYISNTLIQII 136
+ RN LT SLP K S L+ + LP + + T+L E+ +N ++++
Sbjct: 276 LSRNQLT---SLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELV 332
Query: 137 PTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGD 188
P + +R L L KN + LP I L ++ L+V N +PP+ D
Sbjct: 333 PESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPAD 384
>gi|194394161 leucine rich repeat containing 57 [Homo sapiens]
Length = 239
Score = 85.1 bits (209), Expect = 9e-17
Identities = 62/196 (31%), Positives = 108/196 (55%), Gaps = 6/196 (3%)
Query: 102 VFELSGEHWTELPDSLKEQT-HLREWYISNTLIQIIPTY-IQLFQAMRILDLPKNQISHL 159
VF+L TE P L++ T +LR +SN I+ +P I F ++ L L N+++ L
Sbjct: 18 VFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVL 77
Query: 160 PAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFV 219
P EI LK L+ L++ N+L+ +P G L+ L SGN +L LP +L +L+ + +
Sbjct: 78 PDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGN-QLGALPPQLCSLRHLDVM 136
Query: 220 DISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKN--KLTYLPY 277
D+S N+ S+P V + ++ L+++ N ++ + I L+ L +N +L+ LP
Sbjct: 137 DLSKNQIRSIPDSVGELQVIE-LNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQ 195
Query: 278 SMLNLKKLTLLVVSGD 293
S+L+ ++ LL V G+
Sbjct: 196 SILSDSQICLLAVEGN 211
Score = 57.8 bits (138), Expect = 2e-08
Identities = 39/116 (33%), Positives = 63/116 (54%), Gaps = 6/116 (5%)
Query: 203 LMELPFELSNL-KQVTFVDISANKFSSVP-ICVLRMSNLQWLDISSNNLTDLPQDIDRLE 260
L E P +L L + +D+S NK S+P + + + + L+ L +++N LT LP +I L+
Sbjct: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLK 85
Query: 261 ELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMD 316
+L++ L N L LP + L L L +SG+ L LP LC L+ + +MD
Sbjct: 86 KLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCS----LRHLDVMD 137
Score = 53.9 bits (128), Expect = 2e-07
Identities = 41/181 (22%), Positives = 88/181 (48%), Gaps = 9/181 (4%)
Query: 95 GKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKN 154
GK + L+ T LPD + L ++N ++ +P+ A++ L L N
Sbjct: 59 GKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGN 118
Query: 155 QISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLK 214
Q+ LP ++ L++L +++ N ++SIP +G+ + +E L+ + N ++ ++ ++S
Sbjct: 119 QLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIE-LNLNQN-QISQISVKISCCP 176
Query: 215 QVTFVDISAN--KFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKL 272
++ + + N + S +P +L S + L + N +I +L EL+ + Y +
Sbjct: 177 RLKILRLEENCLELSMLPQSILSDSQICLLAVEGNLF-----EIKKLRELEGYDKYMERF 231
Query: 273 T 273
T
Sbjct: 232 T 232
Score = 50.4 bits (119), Expect = 2e-06
Identities = 40/166 (24%), Positives = 81/166 (48%), Gaps = 26/166 (15%)
Query: 139 YIQLFQAMRILDLPKNQISHLPAEIGCL-KNLKELNVGFNYLKSIPPEL-GDCENLERLD 196
+++ Q + L ++ PA++ L NL+ +++ N ++S+PP L G L+ L
Sbjct: 9 HVETAQKTGVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLS 68
Query: 197 CSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDI 256
+ N +L LP E+ NLK+ L+ L +++N+L +LP
Sbjct: 69 LNNN-KLTVLPDEICNLKK-----------------------LETLSLNNNHLRELPSTF 104
Query: 257 DRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
+L L++ L N+L LP + +L+ L ++ +S + + +P ++
Sbjct: 105 GQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSV 150
Score = 47.0 bits (110), Expect = 3e-05
Identities = 44/157 (28%), Positives = 68/157 (43%), Gaps = 11/157 (7%)
Query: 76 LDKIERNTLTRQS--SLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLI 133
L K+E +L LP G+ S+ LSG LP L HL +S I
Sbjct: 84 LKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQI 143
Query: 134 QIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLK--SIPPELGDCEN 191
+ IP + Q + L+L +NQIS + +I C LK L + N L+ +P +
Sbjct: 144 RSIPDSVGELQVIE-LNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQ 202
Query: 192 LERLDCSGNLELMELPFELSNLKQVTFVDISANKFSS 228
+ L GNL FE+ L+++ D +F++
Sbjct: 203 ICLLAVEGNL------FEIKKLRELEGYDKYMERFTA 233
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 84.7 bits (208), Expect = 1e-16
Identities = 56/171 (32%), Positives = 88/171 (51%), Gaps = 1/171 (0%)
Query: 111 TELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLK 170
T LP L HL +S ++ +P + + + L L N +S LP +G L L
Sbjct: 115 TNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALT 174
Query: 171 ELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVP 230
L V N L+++PP LG L+RLD S NL L LP E+ L + +++++N+ S+P
Sbjct: 175 FLTVTHNRLQTLPPALGALSTLQRLDLSQNL-LDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 231 ICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLN 281
+ + +L+ L + SN L +P D+ RL L L N+L LP +L+
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLD 284
Score = 77.4 bits (189), Expect = 2e-14
Identities = 51/150 (34%), Positives = 80/150 (53%), Gaps = 1/150 (0%)
Query: 153 KNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSN 212
+ +++LPA + L +L L++ FN L+++P + L L S N L ELP L
Sbjct: 111 RGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNC-LSELPEALGA 169
Query: 213 LKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKL 272
L +TF+ ++ N+ ++P + +S LQ LD+S N L LP +I L L L N+L
Sbjct: 170 LPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRL 229
Query: 273 TYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
LP S+ L+ L LLV+ + L +P L
Sbjct: 230 QSLPASLAGLRSLRLLVLHSNLLASVPADL 259
Score = 74.3 bits (181), Expect = 2e-13
Identities = 49/199 (24%), Positives = 92/199 (46%), Gaps = 1/199 (0%)
Query: 58 IPQAVYCKNGFIDTSVRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSL 117
+PQ++ C + + D + ++LP + +LS LP +
Sbjct: 85 LPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACV 144
Query: 118 KEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFN 177
+ L +S+ + +P + A+ L + N++ LP +G L L+ L++ N
Sbjct: 145 LQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQN 204
Query: 178 YLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMS 237
L ++PPE+G +L L+ + N L LP L+ L+ + + + +N +SVP + R+
Sbjct: 205 LLDTLPPEIGGLGSLLELNLASN-RLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLP 263
Query: 238 NLQWLDISSNNLTDLPQDI 256
L LD+ N L DLP ++
Sbjct: 264 LLTRLDLRDNQLRDLPPEL 282
Score = 45.4 bits (106), Expect = 8e-05
Identities = 34/101 (33%), Positives = 55/101 (54%), Gaps = 1/101 (0%)
Query: 227 SSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLT 286
+++P + +++L LD+S N+L LP + ++ L + LL N L+ LP ++ L LT
Sbjct: 115 TNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALT 174
Query: 287 LLVVSGDHLVELPTALCDSSTPLKFVSLMDNPIDNAQCEDG 327
L V+ + L LP AL ST L+ + L N +D E G
Sbjct: 175 FLTVTHNRLQTLPPALGALST-LQRLDLSQNLLDTLPPEIG 214
Score = 45.4 bits (106), Expect = 8e-05
Identities = 30/106 (28%), Positives = 53/106 (50%)
Query: 83 TLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQL 142
T R +LP G S+ +LS LP + L E +++ +Q +P +
Sbjct: 179 THNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAG 238
Query: 143 FQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGD 188
+++R+L L N ++ +PA++ L L L++ N L+ +PPEL D
Sbjct: 239 LRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLD 284
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 84.7 bits (208), Expect = 1e-16
Identities = 56/171 (32%), Positives = 88/171 (51%), Gaps = 1/171 (0%)
Query: 111 TELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLK 170
T LP L HL +S ++ +P + + + L L N +S LP +G L L
Sbjct: 115 TNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALT 174
Query: 171 ELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVP 230
L V N L+++PP LG L+RLD S NL L LP E+ L + +++++N+ S+P
Sbjct: 175 FLTVTHNRLQTLPPALGALSTLQRLDLSQNL-LDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 231 ICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLN 281
+ + +L+ L + SN L +P D+ RL L L N+L LP +L+
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLD 284
Score = 77.4 bits (189), Expect = 2e-14
Identities = 51/150 (34%), Positives = 80/150 (53%), Gaps = 1/150 (0%)
Query: 153 KNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSN 212
+ +++LPA + L +L L++ FN L+++P + L L S N L ELP L
Sbjct: 111 RGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNC-LSELPEALGA 169
Query: 213 LKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKL 272
L +TF+ ++ N+ ++P + +S LQ LD+S N L LP +I L L L N+L
Sbjct: 170 LPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRL 229
Query: 273 TYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
LP S+ L+ L LLV+ + L +P L
Sbjct: 230 QSLPASLAGLRSLRLLVLHSNLLASVPADL 259
Score = 74.3 bits (181), Expect = 2e-13
Identities = 49/199 (24%), Positives = 92/199 (46%), Gaps = 1/199 (0%)
Query: 58 IPQAVYCKNGFIDTSVRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSL 117
+PQ++ C + + D + ++LP + +LS LP +
Sbjct: 85 LPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACV 144
Query: 118 KEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFN 177
+ L +S+ + +P + A+ L + N++ LP +G L L+ L++ N
Sbjct: 145 LQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQN 204
Query: 178 YLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMS 237
L ++PPE+G +L L+ + N L LP L+ L+ + + + +N +SVP + R+
Sbjct: 205 LLDTLPPEIGGLGSLLELNLASN-RLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLP 263
Query: 238 NLQWLDISSNNLTDLPQDI 256
L LD+ N L DLP ++
Sbjct: 264 LLTRLDLRDNQLRDLPPEL 282
Score = 45.4 bits (106), Expect = 8e-05
Identities = 34/101 (33%), Positives = 55/101 (54%), Gaps = 1/101 (0%)
Query: 227 SSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLT 286
+++P + +++L LD+S N+L LP + ++ L + LL N L+ LP ++ L LT
Sbjct: 115 TNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALT 174
Query: 287 LLVVSGDHLVELPTALCDSSTPLKFVSLMDNPIDNAQCEDG 327
L V+ + L LP AL ST L+ + L N +D E G
Sbjct: 175 FLTVTHNRLQTLPPALGALST-LQRLDLSQNLLDTLPPEIG 214
Score = 45.4 bits (106), Expect = 8e-05
Identities = 30/106 (28%), Positives = 53/106 (50%)
Query: 83 TLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQL 142
T R +LP G S+ +LS LP + L E +++ +Q +P +
Sbjct: 179 THNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAG 238
Query: 143 FQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGD 188
+++R+L L N ++ +PA++ L L L++ N L+ +PPEL D
Sbjct: 239 LRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLD 284
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 84.3 bits (207), Expect = 2e-16
Identities = 61/190 (32%), Positives = 101/190 (53%), Gaps = 3/190 (1%)
Query: 115 DSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGC--LKNLKEL 172
+SLK+ ++ E + N ++ IP I ++ LDL N I + I LK L L
Sbjct: 629 NSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCL 688
Query: 173 NVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPIC 232
+ N + +IPP + +NLE L S N +L LP + +L+++ +D+S N S +PI
Sbjct: 689 KLWHNKIVTIPPSITHVKNLESLYFSNN-KLESLPVAVFSLQKLRCLDVSYNNISMIPIE 747
Query: 233 VLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSG 292
+ + NLQ L I+ N + LP+ + + +L++ L +N +T LP + L +LT L + G
Sbjct: 748 IGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKG 807
Query: 293 DHLVELPTAL 302
+ L LP L
Sbjct: 808 NCLDRLPAQL 817
Score = 68.2 bits (165), Expect = 1e-11
Identities = 52/206 (25%), Positives = 94/206 (45%), Gaps = 10/206 (4%)
Query: 53 CRRKGIPQAVYCKNGFIDTSVRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTE 112
C + IP A++ + +++ LD N T + + KR + +L
Sbjct: 645 CELERIPHAIFSLS-----NLQELDLKSNNIRTIEEIISFQHLKRLTCL--KLWHNKIVT 697
Query: 113 LPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKEL 172
+P S+ +L Y SN ++ +P + Q +R LD+ N IS +P EIG L+NL+ L
Sbjct: 698 IPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHL 757
Query: 173 NVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVP-- 230
++ N + +P +L C L L+ N + LP ++ L Q+T +++ N +P
Sbjct: 758 HITGNKVDILPKQLFKCIKLRTLNLGQNC-ITSLPEKVGQLSQLTQLELKGNCLDRLPAQ 816
Query: 231 ICVLRMSNLQWLDISSNNLTDLPQDI 256
+ RM L + + LP ++
Sbjct: 817 LGQCRMLKKSGLVVEDHLFDTLPLEV 842
Score = 58.2 bits (139), Expect = 1e-08
Identities = 54/222 (24%), Positives = 99/222 (44%), Gaps = 31/222 (13%)
Query: 112 ELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQA-MRILDLPKNQISHLPAEIGCLKNLK 170
++P + + T+L+E ++ + ++ T + +R L + ++ +PA + LKNL+
Sbjct: 504 KIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLR 563
Query: 171 EL----NVGFNYLKSIPPE-LGDCENLERLDCSGNL------------ELMELPF----- 208
EL N+ K I E L + +L+ L NL L +L
Sbjct: 564 ELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGT 623
Query: 209 ------ELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDI--DRLE 260
L + V +++ + +P + +SNLQ LD+ SNN+ + + I L+
Sbjct: 624 KLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLK 683
Query: 261 ELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
L L+ NK+ +P S+ ++K L L S + L LP A+
Sbjct: 684 RLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAV 725
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 84.3 bits (207), Expect = 2e-16
Identities = 61/190 (32%), Positives = 101/190 (53%), Gaps = 3/190 (1%)
Query: 115 DSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGC--LKNLKEL 172
+SLK+ ++ E + N ++ IP I ++ LDL N I + I LK L L
Sbjct: 629 NSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCL 688
Query: 173 NVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPIC 232
+ N + +IPP + +NLE L S N +L LP + +L+++ +D+S N S +PI
Sbjct: 689 KLWHNKIVTIPPSITHVKNLESLYFSNN-KLESLPVAVFSLQKLRCLDVSYNNISMIPIE 747
Query: 233 VLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSG 292
+ + NLQ L I+ N + LP+ + + +L++ L +N +T LP + L +LT L + G
Sbjct: 748 IGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKG 807
Query: 293 DHLVELPTAL 302
+ L LP L
Sbjct: 808 NCLDRLPAQL 817
Score = 68.2 bits (165), Expect = 1e-11
Identities = 52/206 (25%), Positives = 94/206 (45%), Gaps = 10/206 (4%)
Query: 53 CRRKGIPQAVYCKNGFIDTSVRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTE 112
C + IP A++ + +++ LD N T + + KR + +L
Sbjct: 645 CELERIPHAIFSLS-----NLQELDLKSNNIRTIEEIISFQHLKRLTCL--KLWHNKIVT 697
Query: 113 LPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKEL 172
+P S+ +L Y SN ++ +P + Q +R LD+ N IS +P EIG L+NL+ L
Sbjct: 698 IPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHL 757
Query: 173 NVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVP-- 230
++ N + +P +L C L L+ N + LP ++ L Q+T +++ N +P
Sbjct: 758 HITGNKVDILPKQLFKCIKLRTLNLGQNC-ITSLPEKVGQLSQLTQLELKGNCLDRLPAQ 816
Query: 231 ICVLRMSNLQWLDISSNNLTDLPQDI 256
+ RM L + + LP ++
Sbjct: 817 LGQCRMLKKSGLVVEDHLFDTLPLEV 842
Score = 58.2 bits (139), Expect = 1e-08
Identities = 54/222 (24%), Positives = 99/222 (44%), Gaps = 31/222 (13%)
Query: 112 ELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQA-MRILDLPKNQISHLPAEIGCLKNLK 170
++P + + T+L+E ++ + ++ T + +R L + ++ +PA + LKNL+
Sbjct: 504 KIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLR 563
Query: 171 EL----NVGFNYLKSIPPE-LGDCENLERLDCSGNL------------ELMELPF----- 208
EL N+ K I E L + +L+ L NL L +L
Sbjct: 564 ELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGT 623
Query: 209 ------ELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDI--DRLE 260
L + V +++ + +P + +SNLQ LD+ SNN+ + + I L+
Sbjct: 624 KLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLK 683
Query: 261 ELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
L L+ NK+ +P S+ ++K L L S + L LP A+
Sbjct: 684 RLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAV 725
>gi|63003903 leucine rich repeat containing 10 [Homo sapiens]
Length = 277
Score = 83.2 bits (204), Expect = 3e-16
Identities = 64/195 (32%), Positives = 104/195 (53%), Gaps = 3/195 (1%)
Query: 128 ISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELG 187
+S + ++ P ++ F+ + L L N ++ LP E+G L+NL+ L + FN K++P +
Sbjct: 36 LSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVC 95
Query: 188 DCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSN 247
+ L L GN +L +LP ELS L+ + + I AN + +P V +S L+ L SN
Sbjct: 96 TLKQLCILYL-GNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSN 154
Query: 248 NLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSST 307
L LP + RL+EL++ L N+LT P +L++ L ++ V + + P+ SS
Sbjct: 155 ALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPSLAHLSS- 213
Query: 308 PLKFVSLMDNPIDNA 322
LK V NP NA
Sbjct: 214 -LKLVIYDHNPCRNA 227
Score = 79.3 bits (194), Expect = 5e-15
Identities = 49/156 (31%), Positives = 81/156 (51%), Gaps = 1/156 (0%)
Query: 147 RILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMEL 206
+++DL +Q+ P + + L +L + N+L S+PPELG +NL+ L N L
Sbjct: 32 KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFN-NFKAL 90
Query: 207 PFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFL 266
P + LKQ+ + + NK +P + + NL+ L I +N LT LP + L L++
Sbjct: 91 PQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLH 150
Query: 267 LYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
N L LP + L++L + +SG+ L + PT L
Sbjct: 151 AGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVL 186
Score = 54.3 bits (129), Expect = 2e-07
Identities = 41/167 (24%), Positives = 78/167 (46%), Gaps = 2/167 (1%)
Query: 88 SSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMR 147
+SLP + G+ + + L ++ LP + L Y+ N + +P+ + L Q +R
Sbjct: 65 NSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLR 124
Query: 148 ILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELP 207
L + N ++ LP + L LK L+ G N L+ +P +L + L + SGN L + P
Sbjct: 125 TLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGN-RLTDFP 183
Query: 208 FELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQ 254
L ++ + +D+ N P + +S+L+ + N + P+
Sbjct: 184 TVLLHMPFLEVIDVDWNSIRYFP-SLAHLSSLKLVIYDHNPCRNAPK 229
Score = 48.9 bits (115), Expect = 7e-06
Identities = 30/101 (29%), Positives = 50/101 (49%), Gaps = 7/101 (6%)
Query: 202 ELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEE 261
+L E+P + VD+S ++ P+ V L L +S N+L LP ++ +L+
Sbjct: 24 DLREMPLD-------KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQN 76
Query: 262 LQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
LQ L N LP + LK+L +L + + L +LP+ L
Sbjct: 77 LQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSEL 117
>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
Length = 347
Score = 83.2 bits (204), Expect = 3e-16
Identities = 55/192 (28%), Positives = 96/192 (50%), Gaps = 23/192 (11%)
Query: 136 IPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERL 195
+P+ + ++ L L N I + E+ L L LN+G N L+ +P E+ +L+ L
Sbjct: 29 MPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNL 88
Query: 196 DCSGNL-----------------------ELMELPFELSNLKQVTFVDISANKFSSVPIC 232
SGN L +LP E+S LK +T++ I+ N+ +S+P
Sbjct: 89 HLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRE 148
Query: 233 VLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSG 292
+ + NL L ++ N L +P++I L++LQ LL +N + LP + +LKKL +L ++G
Sbjct: 149 LCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAG 208
Query: 293 DHLVELPTALCD 304
+ + P+ D
Sbjct: 209 NIIQIFPSGFQD 220
Score = 68.2 bits (165), Expect = 1e-11
Identities = 48/162 (29%), Positives = 85/162 (52%), Gaps = 3/162 (1%)
Query: 112 ELPDSLKEQTHLREWYIS-NTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLK 170
E+P+ +K T L+ ++S N + + P Q + +L+L N ++ LP E+ LK+L
Sbjct: 74 EVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLT 133
Query: 171 ELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVP 230
+++ +N L SIP EL ENL L + N +L+ +P E+ LK++ + ++ N +P
Sbjct: 134 YMSINYNQLASIPRELCFLENLVELQLNYN-QLICIPEEIKFLKKLQKLLLARNNIGVLP 192
Query: 231 ICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKL 272
+ + L+ LDI+ N + P L +L+ F N L
Sbjct: 193 EELCDLKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGNPL 233
Score = 67.0 bits (162), Expect = 3e-11
Identities = 55/208 (26%), Positives = 100/208 (48%), Gaps = 29/208 (13%)
Query: 102 VFELSGEHWTELPDSLKEQTHLREWYISNTLI-QIIPTYIQLFQAMRILDLPKNQISHLP 160
+ L+G+ T++P +L + L+ + N LI ++ P L Q + L+L N + +P
Sbjct: 18 IITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQ-LTTLNLGNNLLEEVP 76
Query: 161 AEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSG--NLELMELPFELSNLKQVTF 218
E+ L +LK L++ N + P G C+ L+ L N L +LP E+S LK +T+
Sbjct: 77 EEMKYLTSLKNLHLSGNRICRFAP--GACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTY 134
Query: 219 VDISANKFSSVP--ICVLR---------------------MSNLQWLDISSNNLTDLPQD 255
+ I+ N+ +S+P +C L + LQ L ++ NN+ LP++
Sbjct: 135 MSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEE 194
Query: 256 IDRLEELQSFLLYKNKLTYLPYSMLNLK 283
+ L++L+ + N + P +LK
Sbjct: 195 LCDLKKLRILDIAGNIIQIFPSGFQDLK 222
Score = 52.4 bits (124), Expect = 7e-07
Identities = 47/174 (27%), Positives = 79/174 (45%), Gaps = 10/174 (5%)
Query: 102 VFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPA 161
+ L+ H T+LP + L I+ + IP + + + L L NQ+ +P
Sbjct: 111 LLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPE 170
Query: 162 EIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDI 221
EI LK L++L + N + +P EL D + L LD +GN+ + P +LK F
Sbjct: 171 EIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNI-IQIFPSGFQDLKLREFYCE 229
Query: 222 SANKFSSVPICVLRMSNLQWL-DISS----NNLTD----LPQDIDRLEELQSFL 266
F P+ + N+ L +I+S N L + L DI+R +++S +
Sbjct: 230 GNPLFLQQPVISTQQENVWSLQEITSRFVMNQLAENNPFLMDDIERYPQVRSMI 283
Score = 38.5 bits (88), Expect = 0.010
Identities = 25/108 (23%), Positives = 49/108 (45%)
Query: 210 LSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYK 269
LS K + ++ K + +P + ++ L+ L + +N + + ++ L +L + L
Sbjct: 10 LSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGN 69
Query: 270 NKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDN 317
N L +P M L L L +SG+ + CD L ++L +N
Sbjct: 70 NLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNN 117
>gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
Length = 367
Score = 80.9 bits (198), Expect = 2e-15
Identities = 55/173 (31%), Positives = 91/173 (52%), Gaps = 3/173 (1%)
Query: 111 TELPDSLKEQT-HLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNL 169
T LP++L ++ +L E Y+ + I ++P I ++ LDL N + + EIG L+ L
Sbjct: 54 TSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRAL 113
Query: 170 KELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSV 229
+ L + N L+ +PPE+GD + L+ LD S N L+ LP L + ++ + N+ V
Sbjct: 114 RHLRLANNQLQFLPPEVGDLKELQTLDISTN-RLLTLPERLHMCLSLQYLTVDRNRLWYV 172
Query: 230 PICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKN-KLTYLPYSMLN 281
P + ++ +L L ++ N L LP D+ R ELQ + N L LP + N
Sbjct: 173 PRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYLYN 225
Score = 68.6 bits (166), Expect = 9e-12
Identities = 52/175 (29%), Positives = 88/175 (50%), Gaps = 3/175 (1%)
Query: 144 QAMRILDLPKNQISHLPAEIGC-LKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLE 202
Q + L + +N ++ LP + L NL EL + N + +P +G L+ LD S N
Sbjct: 41 QYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNAL 100
Query: 203 LMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEEL 262
+ P E+ L+ + + ++ N+ +P V + LQ LDIS+N L LP+ + L
Sbjct: 101 EIVCP-EIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSL 159
Query: 263 QSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDN 317
Q + +N+L Y+P + L L L ++G+ L LP L S L++V + +N
Sbjct: 160 QYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDL-GRSRELQYVYVDNN 213
>gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens]
Length = 224
Score = 80.5 bits (197), Expect = 2e-15
Identities = 49/149 (32%), Positives = 78/149 (52%), Gaps = 1/149 (0%)
Query: 135 IIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLER 194
++P I + + +L+ NQI LP +I L+ LK LN+G N L ++P G LE
Sbjct: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 60
Query: 195 LDCS-GNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLP 253
LD + NL LP L + + +S N F +P + +++ LQ L + N+L LP
Sbjct: 61 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP 120
Query: 254 QDIDRLEELQSFLLYKNKLTYLPYSMLNL 282
++I L +L+ + N+LT LP + NL
Sbjct: 121 KEIGELTQLKELHIQGNRLTVLPPELGNL 149
Score = 61.6 bits (148), Expect = 1e-09
Identities = 42/126 (33%), Positives = 67/126 (53%), Gaps = 4/126 (3%)
Query: 69 IDTSVRLLDKIERNTL--TRQSSLPKDRGKRSSAFVFELSGEHWTE--LPDSLKEQTHLR 124
+ T + L K++ L R ++LP+ G + V +L+ + +E LP + T LR
Sbjct: 25 LPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLR 84
Query: 125 EWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPP 184
Y+S+ +I+P I ++IL L N + LP EIG L LKEL++ N L +PP
Sbjct: 85 ALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPP 144
Query: 185 ELGDCE 190
ELG+ +
Sbjct: 145 ELGNLD 150
Score = 49.3 bits (116), Expect = 6e-06
Identities = 32/121 (26%), Positives = 55/121 (45%), Gaps = 3/121 (2%)
Query: 112 ELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISH--LPAEIGCLKNL 169
ELP + L+ + + +P A+ +LDL N +S LP L L
Sbjct: 24 ELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTL 83
Query: 170 KELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSV 229
+ L + N + +PP++G L+ L N +L+ LP E+ L Q+ + I N+ + +
Sbjct: 84 RALYLSDNDFEILPPDIGKLTKLQILSLRDN-DLISLPKEIGELTQLKELHIQGNRLTVL 142
Query: 230 P 230
P
Sbjct: 143 P 143
>gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
Length = 803
Score = 79.7 bits (195), Expect = 4e-15
Identities = 56/190 (29%), Positives = 99/190 (52%), Gaps = 3/190 (1%)
Query: 115 DSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGC--LKNLKEL 172
++LK+ +L+ + + ++ IP I + LDL +N + + I L+NL L
Sbjct: 579 NNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCL 638
Query: 173 NVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPIC 232
+ N + IP ++G NLE+L N + LP +L ++ ++D+S N + +P
Sbjct: 639 KLWHNNIAYIPAQIGALSNLEQLSLDHN-NIENLPLQLFLCTKLHYLDLSYNHLTFIPEE 697
Query: 233 VLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSG 292
+ +SNLQ+ +++NN+ LP + + ++LQ LL KN L L + L LT L + G
Sbjct: 698 IQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIG 757
Query: 293 DHLVELPTAL 302
++L LP L
Sbjct: 758 NYLETLPPEL 767
Score = 60.8 bits (146), Expect = 2e-09
Identities = 35/129 (27%), Positives = 71/129 (55%), Gaps = 2/129 (1%)
Query: 68 FIDTSVRLLDKIERNTLTRQS--SLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLRE 125
+I + L +E+ +L + +LP + +LS H T +P+ ++ ++L+
Sbjct: 647 YIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQY 706
Query: 126 WYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPE 185
+ ++N I+++P + + ++ L L KN + +L +G L NL L + NYL+++PPE
Sbjct: 707 FAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPE 766
Query: 186 LGDCENLER 194
L C++L+R
Sbjct: 767 LEGCQSLKR 775
Score = 51.6 bits (122), Expect = 1e-06
Identities = 59/257 (22%), Positives = 110/257 (42%), Gaps = 32/257 (12%)
Query: 77 DKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYI-SNTLIQI 135
DKIE + L + LP + + + V L +LP ++ + +L+E + ++L+
Sbjct: 420 DKIELH-LFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVD 478
Query: 136 IPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKEL----------------------- 172
P L + ++IL L ++ +P + LKNLKEL
Sbjct: 479 HPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLK 538
Query: 173 NVGFNYLKS----IPPELGD-CENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFS 227
N+ YLKS IP + D +L++L + + L + + +++ +
Sbjct: 539 NLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLE 598
Query: 228 SVPICVLRMSNLQWLDISSNNLTDLPQDI--DRLEELQSFLLYKNKLTYLPYSMLNLKKL 285
+P + ++NL LD+ NNL + + I L+ L L+ N + Y+P + L L
Sbjct: 599 RIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNL 658
Query: 286 TLLVVSGDHLVELPTAL 302
L + +++ LP L
Sbjct: 659 EQLSLDHNNIENLPLQL 675
Score = 43.5 bits (101), Expect = 3e-04
Identities = 39/146 (26%), Positives = 63/146 (43%), Gaps = 3/146 (2%)
Query: 90 LPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRIL 149
+P G S+ L + LP L T L +S + IP IQ ++
Sbjct: 648 IPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYF 707
Query: 150 DLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFE 209
+ N I LP + K L+ L +G N L ++ P +G+ NL L+ GN L LP E
Sbjct: 708 AVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNY-LETLPPE 766
Query: 210 LSNLKQV--TFVDISANKFSSVPICV 233
L + + + + N +++P+ V
Sbjct: 767 LEGCQSLKRNCLIVEENLLNTLPLPV 792
>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
sapiens]
Length = 803
Score = 79.7 bits (195), Expect = 4e-15
Identities = 56/190 (29%), Positives = 99/190 (52%), Gaps = 3/190 (1%)
Query: 115 DSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGC--LKNLKEL 172
++LK+ +L+ + + ++ IP I + LDL +N + + I L+NL L
Sbjct: 579 NNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCL 638
Query: 173 NVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPIC 232
+ N + IP ++G NLE+L N + LP +L ++ ++D+S N + +P
Sbjct: 639 KLWHNNIAYIPAQIGALSNLEQLSLDHN-NIENLPLQLFLCTKLHYLDLSYNHLTFIPEE 697
Query: 233 VLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSG 292
+ +SNLQ+ +++NN+ LP + + ++LQ LL KN L L + L LT L + G
Sbjct: 698 IQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIG 757
Query: 293 DHLVELPTAL 302
++L LP L
Sbjct: 758 NYLETLPPEL 767
Score = 60.8 bits (146), Expect = 2e-09
Identities = 35/129 (27%), Positives = 71/129 (55%), Gaps = 2/129 (1%)
Query: 68 FIDTSVRLLDKIERNTLTRQS--SLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLRE 125
+I + L +E+ +L + +LP + +LS H T +P+ ++ ++L+
Sbjct: 647 YIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQY 706
Query: 126 WYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPE 185
+ ++N I+++P + + ++ L L KN + +L +G L NL L + NYL+++PPE
Sbjct: 707 FAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPE 766
Query: 186 LGDCENLER 194
L C++L+R
Sbjct: 767 LEGCQSLKR 775
Score = 51.6 bits (122), Expect = 1e-06
Identities = 59/257 (22%), Positives = 110/257 (42%), Gaps = 32/257 (12%)
Query: 77 DKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYI-SNTLIQI 135
DKIE + L + LP + + + V L +LP ++ + +L+E + ++L+
Sbjct: 420 DKIELH-LFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVD 478
Query: 136 IPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKEL----------------------- 172
P L + ++IL L ++ +P + LKNLKEL
Sbjct: 479 HPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLK 538
Query: 173 NVGFNYLKS----IPPELGD-CENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFS 227
N+ YLKS IP + D +L++L + + L + + +++ +
Sbjct: 539 NLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLE 598
Query: 228 SVPICVLRMSNLQWLDISSNNLTDLPQDI--DRLEELQSFLLYKNKLTYLPYSMLNLKKL 285
+P + ++NL LD+ NNL + + I L+ L L+ N + Y+P + L L
Sbjct: 599 RIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNL 658
Query: 286 TLLVVSGDHLVELPTAL 302
L + +++ LP L
Sbjct: 659 EQLSLDHNNIENLPLQL 675
Score = 43.5 bits (101), Expect = 3e-04
Identities = 39/146 (26%), Positives = 63/146 (43%), Gaps = 3/146 (2%)
Query: 90 LPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRIL 149
+P G S+ L + LP L T L +S + IP IQ ++
Sbjct: 648 IPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYF 707
Query: 150 DLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFE 209
+ N I LP + K L+ L +G N L ++ P +G+ NL L+ GN L LP E
Sbjct: 708 AVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNY-LETLPPE 766
Query: 210 LSNLKQV--TFVDISANKFSSVPICV 233
L + + + + N +++P+ V
Sbjct: 767 LEGCQSLKRNCLIVEENLLNTLPLPV 792
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 77.4 bits (189), Expect = 2e-14
Identities = 63/237 (26%), Positives = 117/237 (49%), Gaps = 6/237 (2%)
Query: 122 HLREWYISNTLIQIIP-TYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLK 180
HL++ I+N ++I ++ + L+L + + +P I L NL+E+++ N LK
Sbjct: 568 HLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLK 627
Query: 181 SIPPELGDCENLERLDCSGNL--ELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSN 238
+I E+ ++L RL C + +P ++ NL + + ++ NK +P +
Sbjct: 628 TIE-EIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRK 686
Query: 239 LQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVEL 298
L++LD+S NNLT LP DI L+ LQ+ + N++ LP + +KL L + + L L
Sbjct: 687 LRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSL 746
Query: 299 PTALCDSSTPLKFVSLMDNPIDNAQCEDGNEIMESERDRQHFDKEVMKAYIEDLKER 355
P+ + T L + L N ++ E G E +R ++++ ++KER
Sbjct: 747 PSRV-GELTNLTQIELRGNRLECLPVELG-ECPLLKRSGLVVEEDLFNTLPPEVKER 801
Score = 77.4 bits (189), Expect = 2e-14
Identities = 40/123 (32%), Positives = 67/123 (54%), Gaps = 1/123 (0%)
Query: 109 HWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKN 168
H +P + T+L Y++ I+ IPT + + +R LDL N ++ LPA+IG L+N
Sbjct: 650 HIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQN 709
Query: 169 LKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSS 228
L+ L + N ++++PPEL C L L GN L LP + L +T +++ N+
Sbjct: 710 LQNLAITANRIETLPPELFQCRKLRALHL-GNNVLQSLPSRVGELTNLTQIELRGNRLEC 768
Query: 229 VPI 231
+P+
Sbjct: 769 LPV 771
Score = 48.5 bits (114), Expect = 9e-06
Identities = 76/360 (21%), Positives = 136/360 (37%), Gaps = 69/360 (19%)
Query: 5 VVVFDISVIRALWETRVKKHKAWQKKEV-ERLEKSALEKIKEEWNFVAECRRKGIPQAVY 63
V+ + + + LW + K + + + E S + +K ++ F+ + P +Y
Sbjct: 329 VIFYGLICMYTLWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFMLHLIDQYDP--LY 386
Query: 64 CKNGFIDTSVRLLDKIERNTLTRQSSLPKDRGK-------RSSAFVFELSGEHWTELPDS 116
K + S +K+ + L + +L K R + + +F LSG +PD+
Sbjct: 387 SKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLSG-----IPDT 441
Query: 117 LKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQIS-HLPAEIGCLKNLKELNVG 175
+ + L + IP I ++ L L PA +NL+ L++
Sbjct: 442 VFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIK 501
Query: 176 FNYLKSIPPELGDCENLERLDCSGN-------------------LELMELPFELSNLKQ- 215
F +K IP + + LE L +GN L+++ L LS L Q
Sbjct: 502 FTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQV 561
Query: 216 VTFVDISANKFS-------------------------------SVPICVLRMSNLQWLDI 244
VT V + K S +P + + NLQ +D+
Sbjct: 562 VTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDL 621
Query: 245 SSNNLTDLPQDI--DRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
NNL + + I L L L+ N + Y+P + NL L L ++ + + ++PT L
Sbjct: 622 KDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQL 681
Score = 48.5 bits (114), Expect = 9e-06
Identities = 35/129 (27%), Positives = 60/129 (46%), Gaps = 2/129 (1%)
Query: 68 FIDTSVRLLDKIERNTLTRQS--SLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLRE 125
+I + L +ER L R +P +LS + T LP + +L+
Sbjct: 653 YIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQN 712
Query: 126 WYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPE 185
I+ I+ +P + + +R L L N + LP+ +G L NL ++ + N L+ +P E
Sbjct: 713 LAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVE 772
Query: 186 LGDCENLER 194
LG+C L+R
Sbjct: 773 LGECPLLKR 781
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 77.4 bits (189), Expect = 2e-14
Identities = 63/237 (26%), Positives = 117/237 (49%), Gaps = 6/237 (2%)
Query: 122 HLREWYISNTLIQIIP-TYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLK 180
HL++ I+N ++I ++ + L+L + + +P I L NL+E+++ N LK
Sbjct: 568 HLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLK 627
Query: 181 SIPPELGDCENLERLDCSGNL--ELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSN 238
+I E+ ++L RL C + +P ++ NL + + ++ NK +P +
Sbjct: 628 TIE-EIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRK 686
Query: 239 LQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVEL 298
L++LD+S NNLT LP DI L+ LQ+ + N++ LP + +KL L + + L L
Sbjct: 687 LRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSL 746
Query: 299 PTALCDSSTPLKFVSLMDNPIDNAQCEDGNEIMESERDRQHFDKEVMKAYIEDLKER 355
P+ + T L + L N ++ E G E +R ++++ ++KER
Sbjct: 747 PSRV-GELTNLTQIELRGNRLECLPVELG-ECPLLKRSGLVVEEDLFNTLPPEVKER 801
Score = 77.4 bits (189), Expect = 2e-14
Identities = 40/123 (32%), Positives = 67/123 (54%), Gaps = 1/123 (0%)
Query: 109 HWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKN 168
H +P + T+L Y++ I+ IPT + + +R LDL N ++ LPA+IG L+N
Sbjct: 650 HIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQN 709
Query: 169 LKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSS 228
L+ L + N ++++PPEL C L L GN L LP + L +T +++ N+
Sbjct: 710 LQNLAITANRIETLPPELFQCRKLRALHL-GNNVLQSLPSRVGELTNLTQIELRGNRLEC 768
Query: 229 VPI 231
+P+
Sbjct: 769 LPV 771
Score = 48.5 bits (114), Expect = 9e-06
Identities = 76/360 (21%), Positives = 136/360 (37%), Gaps = 69/360 (19%)
Query: 5 VVVFDISVIRALWETRVKKHKAWQKKEV-ERLEKSALEKIKEEWNFVAECRRKGIPQAVY 63
V+ + + + LW + K + + + E S + +K ++ F+ + P +Y
Sbjct: 329 VIFYGLICMYTLWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFMLHLIDQYDP--LY 386
Query: 64 CKNGFIDTSVRLLDKIERNTLTRQSSLPKDRGK-------RSSAFVFELSGEHWTELPDS 116
K + S +K+ + L + +L K R + + +F LSG +PD+
Sbjct: 387 SKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLSG-----IPDT 441
Query: 117 LKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQIS-HLPAEIGCLKNLKELNVG 175
+ + L + IP I ++ L L PA +NL+ L++
Sbjct: 442 VFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIK 501
Query: 176 FNYLKSIPPELGDCENLERLDCSGN-------------------LELMELPFELSNLKQ- 215
F +K IP + + LE L +GN L+++ L LS L Q
Sbjct: 502 FTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQV 561
Query: 216 VTFVDISANKFS-------------------------------SVPICVLRMSNLQWLDI 244
VT V + K S +P + + NLQ +D+
Sbjct: 562 VTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDL 621
Query: 245 SSNNLTDLPQDI--DRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
NNL + + I L L L+ N + Y+P + NL L L ++ + + ++PT L
Sbjct: 622 KDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQL 681
Score = 48.5 bits (114), Expect = 9e-06
Identities = 35/129 (27%), Positives = 60/129 (46%), Gaps = 2/129 (1%)
Query: 68 FIDTSVRLLDKIERNTLTRQS--SLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLRE 125
+I + L +ER L R +P +LS + T LP + +L+
Sbjct: 653 YIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQN 712
Query: 126 WYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPE 185
I+ I+ +P + + +R L L N + LP+ +G L NL ++ + N L+ +P E
Sbjct: 713 LAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVE 772
Query: 186 LGDCENLER 194
LG+C L+R
Sbjct: 773 LGECPLLKR 781
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,415,190
Number of Sequences: 37866
Number of extensions: 567410
Number of successful extensions: 3279
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 91
Number of HSP's successfully gapped in prelim test: 128
Number of HSP's that attempted gapping in prelim test: 1943
Number of HSP's gapped (non-prelim): 693
length of query: 371
length of database: 18,247,518
effective HSP length: 104
effective length of query: 267
effective length of database: 14,309,454
effective search space: 3820624218
effective search space used: 3820624218
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.