BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|26051223 sperm-associated cation channel 2 isoform 2 [Homo sapiens] (530 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|26051223 sperm-associated cation channel 2 isoform 2 [Homo sa... 1031 0.0 gi|16876443 sperm-associated cation channel 2 isoform 1 [Homo sa... 1023 0.0 gi|26051227 sperm-associated cation channel 2 isoform 4 [Homo sa... 374 e-103 gi|150417969 voltage-gated sodium channel type V alpha isoform d... 100 4e-21 gi|20070163 voltage-dependent calcium channel alpha 1G subunit i... 100 6e-21 gi|38505284 voltage-dependent calcium channel alpha 1G subunit i... 100 6e-21 gi|38505282 voltage-dependent calcium channel alpha 1G subunit i... 100 6e-21 gi|38505280 voltage-dependent calcium channel alpha 1G subunit i... 100 6e-21 gi|38505278 voltage-dependent calcium channel alpha 1G subunit i... 100 6e-21 gi|38505270 voltage-dependent calcium channel alpha 1G subunit i... 100 6e-21 gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B ... 100 6e-21 gi|62988334 cation channel, sperm associated 4 [Homo sapiens] 98 2e-20 gi|38505292 voltage-dependent calcium channel alpha 1G subunit i... 98 2e-20 gi|38505288 voltage-dependent calcium channel alpha 1G subunit i... 98 2e-20 gi|38505276 voltage-dependent calcium channel alpha 1G subunit i... 98 2e-20 gi|38505274 voltage-dependent calcium channel alpha 1G subunit i... 98 2e-20 gi|38505272 voltage-dependent calcium channel alpha 1G subunit i... 98 2e-20 gi|38505268 voltage-dependent calcium channel alpha 1G subunit i... 98 2e-20 gi|38505290 voltage-dependent calcium channel alpha 1G subunit i... 97 5e-20 gi|38505286 voltage-dependent calcium channel alpha 1G subunit i... 97 5e-20 gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H... 96 1e-19 gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H... 96 1e-19 gi|193788732 calcium channel, voltage-dependent, L type, alpha 1... 95 2e-19 gi|193788730 calcium channel, voltage-dependent, L type, alpha 1... 95 2e-19 gi|193788728 calcium channel, voltage-dependent, L type, alpha 1... 95 2e-19 gi|193788724 calcium channel, voltage-dependent, L type, alpha 1... 95 2e-19 gi|193788720 calcium channel, voltage-dependent, L type, alpha 1... 95 2e-19 gi|120433602 calcium channel, voltage-dependent, L type, alpha 1... 95 2e-19 gi|193788548 calcium channel, voltage-dependent, L type, alpha 1... 95 2e-19 gi|193788544 calcium channel, voltage-dependent, L type, alpha 1... 95 2e-19 >gi|26051223 sperm-associated cation channel 2 isoform 2 [Homo sapiens] Length = 530 Score = 1031 bits (2665), Expect = 0.0 Identities = 530/530 (100%), Positives = 530/530 (100%) Query: 1 MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD 60 MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD Sbjct: 1 MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD 60 Query: 61 QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL 120 QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL Sbjct: 61 QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL 120 Query: 121 NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF 180 NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF Sbjct: 121 NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF 180 Query: 181 DFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKS 240 DFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKS Sbjct: 181 DFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKS 240 Query: 241 MTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWY 300 MTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWY Sbjct: 241 MTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWY 300 Query: 301 ALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREV 360 ALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREV Sbjct: 301 ALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREV 360 Query: 361 QLKADMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGASQQRESLDLSEVSEVESNYGATE 420 QLKADMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGASQQRESLDLSEVSEVESNYGATE Sbjct: 361 QLKADMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGASQQRESLDLSEVSEVESNYGATE 420 Query: 421 EDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPG 480 EDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPG Sbjct: 421 EDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPG 480 Query: 481 LMEMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK 530 LMEMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK Sbjct: 481 LMEMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK 530 >gi|16876443 sperm-associated cation channel 2 isoform 1 [Homo sapiens] Length = 528 Score = 1023 bits (2644), Expect = 0.0 Identities = 528/530 (99%), Positives = 528/530 (99%), Gaps = 2/530 (0%) Query: 1 MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD 60 MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD Sbjct: 1 MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD 60 Query: 61 QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL 120 QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL Sbjct: 61 QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL 120 Query: 121 NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF 180 NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF Sbjct: 121 NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF 180 Query: 181 DFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKS 240 DFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKS Sbjct: 181 DFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKS 240 Query: 241 MTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWY 300 MTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWY Sbjct: 241 MTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWY 300 Query: 301 ALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREV 360 ALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREV Sbjct: 301 ALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREV 360 Query: 361 QLKADMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGASQQRESLDLSEVSEVESNYGATE 420 QLKADMFKRQIIQRRKNMSHEALTSSHSKIED RGASQQRESLDLSEVSEVESNYGATE Sbjct: 361 QLKADMFKRQIIQRRKNMSHEALTSSHSKIED--RGASQQRESLDLSEVSEVESNYGATE 418 Query: 421 EDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPG 480 EDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPG Sbjct: 419 EDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPG 478 Query: 481 LMEMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK 530 LMEMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK Sbjct: 479 LMEMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK 528 >gi|26051227 sperm-associated cation channel 2 isoform 4 [Homo sapiens] Length = 199 Score = 374 bits (959), Expect = e-103 Identities = 187/187 (100%), Positives = 187/187 (100%) Query: 1 MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD 60 MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD Sbjct: 1 MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD 60 Query: 61 QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL 120 QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL Sbjct: 61 QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL 120 Query: 121 NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF 180 NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF Sbjct: 121 NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF 180 Query: 181 DFVVTML 187 DFVVTML Sbjct: 181 DFVVTML 187 >gi|150417969 voltage-gated sodium channel type V alpha isoform d [Homo sapiens] Length = 1998 Score = 100 bits (248), Expect = 4e-21 Identities = 74/267 (27%), Positives = 141/267 (52%), Gaps = 24/267 (8%) Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163 ++E F+ FIIF++ L++ L E LE T +K+ LE A +F+LE+LL Sbjct: 1201 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKT----IKVLLEYADKMFTYVFVLEMLL 1256 Query: 164 KWLS-NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLA 222 KW++ F ++ +AW DF++ +SL+ V +G ++ LR R LR L+ L+ Sbjct: 1257 KWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGP-IKSLRTLRALRPLRALS 1315 Query: 223 QFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFS-EYTRSPRQ-----DLEY 276 +F +++++ LV A+ S+ +L++ LIF+ IF++ GV +F+ ++ R Q L Y Sbjct: 1316 RFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNY 1375 Query: 277 HVFFS-------DLPNSLVTVFILFTLDH----WYALLQDVWKVPEVS-RIFSSIYFILW 324 + + +L L + D+ + ALLQ + P+ ++ IYF+++ Sbjct: 1376 TIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVYEEQPQWEYNLYMYIYFVIF 1435 Query: 325 LLLGSIIFRSIIVAMMVTNFQNIRKEL 351 ++ GS ++ + +++ NF +K+L Sbjct: 1436 IIFGSFFTLNLFIGVIIDNFNQQKKKL 1462 Score = 74.7 bits (182), Expect = 2e-13 Identities = 78/392 (19%), Positives = 182/392 (46%), Gaps = 44/392 (11%) Query: 47 LLDPSRQKKLVLGDQHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRP---PLSLWAGW 103 ++D Q+K LG Q + E+ + +L + Q+P PL+ + G+ Sbjct: 1451 IIDNFNQQKKKLGGQDIFMT--------EEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGF 1502 Query: 104 VLECPLFKNF---IIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILE 160 + + + F I+FL+ LN + +MVE + + + K+ + ++ F+ IF E Sbjct: 1503 IFDIVTKQAFDVTIMFLICLNMVTMMVETD--DQSPEKI---NILAKINLLFVA-IFTGE 1556 Query: 161 ILLKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVV--VLVGVTGQSVWLQLLRICRVLRSL 218 ++K + ++ ++WN+FDFVV +LS++ V+ ++ +++R+ R+ R L Sbjct: 1557 CIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRIL 1616 Query: 219 KLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHV 278 +L+ + I+ ++ L+ +L ++ + +LL + +I+++ G+ F+ D ++ Sbjct: 1617 RLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFN- 1675 Query: 279 FFSDLPNSLVTVFILFTLDHWYALLQDVWKV------PEV-----------SRIFSSIYF 321 F NS++ +F + T W LL + P + S ++F Sbjct: 1676 -FQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFF 1734 Query: 322 ILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRKNMSHE 381 ++++ +I ++ +A+++ NF +E E ++ + + +++++ + + + + Sbjct: 1735 TTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS 1794 Query: 382 ALTSSHSKIEDSSRGASQQRESL---DLSEVS 410 L+ + + R A + SL DL VS Sbjct: 1795 VLSDFADALSEPLRIAKPNQISLINMDLPMVS 1826 Score = 61.6 bits (148), Expect = 2e-09 Identities = 92/432 (21%), Positives = 183/432 (42%), Gaps = 78/432 (18%) Query: 114 IIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVF 172 I + LNT+ + +E + S ++ L+V IF E+ K ++ + + Sbjct: 723 ITMCIVLNTLFMALEHYNMTSEFEEM------LQVGNLVFTGIFTAEMTFKIIALDPYYY 776 Query: 173 WKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIIL 232 ++ WN+FD ++ +LSL+ +G++ S L +LR R+LR KL + + +I Sbjct: 777 FQQGWNIFDSIIVILSLME-----LGLSRMSN-LSVLRSFRLLRVFKLAKSWPTLNTLIK 830 Query: 233 VLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE---YTRSPRQDLEYHVFFSDLPNSLVT 289 ++ ++ ++ L ++L I +IFAV G+ +F + R L D ++ + Sbjct: 831 IIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLI 890 Query: 290 VFILFTLDHWYALLQDVWKVPEVS-RIFSSIYFILWLLLGSIIFRSIIVAMMVTNF---- 344 +F + W ++ +W EVS + + F+L +++G+++ ++ +A+++++F Sbjct: 891 IFRIL-CGEW---IETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADN 946 Query: 345 ----QNIRKELNEEMARREVQLKADMFKRQI------IQRRKNMSHEAL----------- 383 R+ N ++A +Q KR + R++ AL Sbjct: 947 LTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIA 1006 Query: 384 ---------------TSSHSKIEDS---SRGASQQRESLDLSEVSEVESNYGATEEDLIT 425 T ++ E+ +G E + + ++ ES+ EED Sbjct: 1007 TPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCV-PIAVAESDTDDQEEDEEN 1065 Query: 426 SASKTEETLSKKREYQ----------SSSCVSSTSSSYSSSSESRFSESIGRLDWETLVH 475 S TEE SK++E Q S S S++ SS +E+ S++ R W+ Sbjct: 1066 SLG-TEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWK--AE 1122 Query: 476 ENLPGLMEMDQD 487 PG E +D Sbjct: 1123 PQAPGCGETPED 1134 Score = 47.8 bits (112), Expect = 3e-05 Identities = 68/271 (25%), Positives = 116/271 (42%), Gaps = 51/271 (18%) Query: 6 QEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELL---DP--SRQKK-LVLG 59 QE + LP +A R +L + L L P+ I E L DP S QK +VL Sbjct: 40 QESREGLPEEEAPRPQL--DLQASKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLN 97 Query: 60 DQHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVF 119 + RFS ++A +LS H P+ A +L LF N +I Sbjct: 98 KGKTIFRFSA--------TNALYVLSPFH-------PIRRAAVKILVHSLF-NMLIMCTI 141 Query: 120 LNTIILMVE------IELLESTNTKLWPLKLTLEVAA-WFILLIFILEILLKWLSNFSVF 172 L + M + + +E T T ++ + +++ A F L F F Sbjct: 142 LTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAF-------------TF 188 Query: 173 WKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIIL 232 + WN DF V +++ + E + L L LR RVLR+LK ++ ++ I+ Sbjct: 189 LRDPWNWLDFSVIIMAYVSENIKLGN-------LSALRTFRVLRALKTISVIPGLKTIVG 241 Query: 233 VLVRALKSMTFLLMLLLIFFYIFAVTGVYVF 263 L++++K + +++L + +FA+ G+ +F Sbjct: 242 ALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272 Score = 33.9 bits (76), Expect = 0.38 Identities = 36/139 (25%), Positives = 61/139 (43%), Gaps = 24/139 (17%) Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339 F + + +F L T D W L Q + +I+ I+F+L + LGS ++I+A+ Sbjct: 355 FDSFAWAFLALFRLMTQDCWERLYQQTLR--SAGKIYM-IFFMLVIFLGSFYLVNLILAV 411 Query: 340 MVTNF--QNIRKELNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGA 397 + + QN E + Q +M K++ HEALT RG Sbjct: 412 VAMAYEEQNQATIAETEEKEKRFQEAMEMLKKE---------HEALT---------IRGV 453 Query: 398 -SQQRESLDLSEVSEVESN 415 + R SL++S ++ V S+ Sbjct: 454 DTVSRSSLEMSPLAPVNSH 472 >gi|20070163 voltage-dependent calcium channel alpha 1G subunit isoform 1 [Homo sapiens] Length = 2377 Score = 99.8 bits (247), Expect = 6e-21 Identities = 68/318 (21%), Positives = 162/318 (50%), Gaps = 40/318 (12%) Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164 +F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K Sbjct: 1277 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1332 Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221 W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++ Sbjct: 1333 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1392 Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263 ++ + +++++ L+ +LK + ++++ FF IF + GV +F Sbjct: 1393 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1452 Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316 S+ + + + + F +L +L+++F+L + D W ++ D V + + Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512 Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376 +YFI +LL+ + ++ V ++V NF R+ EE ARR + + R++ ++R+ Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL----RRLEKKRR 1568 Query: 377 NMSHEALTSSHSKIEDSS 394 N+ + + +S S +S Sbjct: 1569 NLMLDDVIASGSSASAAS 1586 Score = 92.8 bits (229), Expect = 7e-19 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%) Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200 L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V + Sbjct: 1643 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1702 Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260 ++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV Sbjct: 1703 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1762 Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312 +F + P + L H F + + +T+F + T D+W +++D + + Sbjct: 1763 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1822 Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366 + + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M Sbjct: 1823 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1875 Score = 88.2 bits (217), Expect = 2e-17 Identities = 76/270 (28%), Positives = 138/270 (51%), Gaps = 21/270 (7%) Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152 P S+ A W L C F+ + F I++ + + L P +LT LE++ Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781 Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211 +F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835 Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271 R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895 Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329 L F L ++VTVF + T + W +L + + ++++YFI + G+ Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952 Query: 330 IIFRSIIVAMMVTNFQNIRKELNEEMARRE 359 + +++VA++V FQ EE+++RE Sbjct: 953 YVLFNLLVAILVEGFQ------AEEISKRE 976 Score = 49.3 bits (116), Expect = 9e-06 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%) Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206 FI F +E+++K ++ +F K WN DF + + +L + L Q+V Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176 Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266 +R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++ Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236 Query: 267 TRS 269 R+ Sbjct: 237 LRN 239 Score = 37.0 bits (84), Expect = 0.045 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%) Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339 F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + + Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393 Query: 340 MVTNFQNIRKELNEEMARREVQ 361 + T F ++ ++ M + V+ Sbjct: 394 IATQFSETKQRESQLMREQRVR 415 >gi|38505284 voltage-dependent calcium channel alpha 1G subunit isoform 4 [Homo sapiens] Length = 2332 Score = 99.8 bits (247), Expect = 6e-21 Identities = 68/318 (21%), Positives = 162/318 (50%), Gaps = 40/318 (12%) Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164 +F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K Sbjct: 1277 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1332 Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221 W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++ Sbjct: 1333 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1392 Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263 ++ + +++++ L+ +LK + ++++ FF IF + GV +F Sbjct: 1393 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1452 Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316 S+ + + + + F +L +L+++F+L + D W ++ D V + + Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512 Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376 +YFI +LL+ + ++ V ++V NF R+ EE ARR + + R++ ++R+ Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL----RRLEKKRR 1568 Query: 377 NMSHEALTSSHSKIEDSS 394 N+ + + +S S +S Sbjct: 1569 NLMLDDVIASGSSASAAS 1586 Score = 92.8 bits (229), Expect = 7e-19 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%) Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200 L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V + Sbjct: 1643 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1702 Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260 ++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV Sbjct: 1703 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1762 Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312 +F + P + L H F + + +T+F + T D+W +++D + + Sbjct: 1763 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1822 Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366 + + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M Sbjct: 1823 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1875 Score = 88.2 bits (217), Expect = 2e-17 Identities = 76/270 (28%), Positives = 138/270 (51%), Gaps = 21/270 (7%) Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152 P S+ A W L C F+ + F I++ + + L P +LT LE++ Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781 Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211 +F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835 Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271 R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895 Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329 L F L ++VTVF + T + W +L + + ++++YFI + G+ Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952 Query: 330 IIFRSIIVAMMVTNFQNIRKELNEEMARRE 359 + +++VA++V FQ EE+++RE Sbjct: 953 YVLFNLLVAILVEGFQ------AEEISKRE 976 Score = 49.3 bits (116), Expect = 9e-06 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%) Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206 FI F +E+++K ++ +F K WN DF + + +L + L Q+V Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176 Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266 +R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++ Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236 Query: 267 TRS 269 R+ Sbjct: 237 LRN 239 Score = 37.0 bits (84), Expect = 0.045 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%) Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339 F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + + Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393 Query: 340 MVTNFQNIRKELNEEMARREVQ 361 + T F ++ ++ M + V+ Sbjct: 394 IATQFSETKQRESQLMREQRVR 415 >gi|38505282 voltage-dependent calcium channel alpha 1G subunit isoform 8 [Homo sapiens] Length = 2284 Score = 99.8 bits (247), Expect = 6e-21 Identities = 68/318 (21%), Positives = 162/318 (50%), Gaps = 40/318 (12%) Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164 +F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K Sbjct: 1277 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1332 Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221 W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++ Sbjct: 1333 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1392 Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263 ++ + +++++ L+ +LK + ++++ FF IF + GV +F Sbjct: 1393 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1452 Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316 S+ + + + + F +L +L+++F+L + D W ++ D V + + Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512 Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376 +YFI +LL+ + ++ V ++V NF R+ EE ARR + + R++ ++R+ Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL----RRLEKKRR 1568 Query: 377 NMSHEALTSSHSKIEDSS 394 N+ + + +S S +S Sbjct: 1569 NLMLDDVIASGSSASAAS 1586 Score = 92.8 bits (229), Expect = 7e-19 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%) Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200 L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V + Sbjct: 1643 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1702 Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260 ++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV Sbjct: 1703 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1762 Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312 +F + P + L H F + + +T+F + T D+W +++D + + Sbjct: 1763 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1822 Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366 + + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M Sbjct: 1823 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1875 Score = 88.2 bits (217), Expect = 2e-17 Identities = 76/270 (28%), Positives = 138/270 (51%), Gaps = 21/270 (7%) Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152 P S+ A W L C F+ + F I++ + + L P +LT LE++ Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781 Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211 +F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835 Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271 R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895 Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329 L F L ++VTVF + T + W +L + + ++++YFI + G+ Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952 Query: 330 IIFRSIIVAMMVTNFQNIRKELNEEMARRE 359 + +++VA++V FQ EE+++RE Sbjct: 953 YVLFNLLVAILVEGFQ------AEEISKRE 976 Score = 49.3 bits (116), Expect = 9e-06 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%) Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206 FI F +E+++K ++ +F K WN DF + + +L + L Q+V Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176 Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266 +R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++ Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236 Query: 267 TRS 269 R+ Sbjct: 237 LRN 239 Score = 37.0 bits (84), Expect = 0.045 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%) Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339 F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + + Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393 Query: 340 MVTNFQNIRKELNEEMARREVQ 361 + T F ++ ++ M + V+ Sbjct: 394 IATQFSETKQRESQLMREQRVR 415 >gi|38505280 voltage-dependent calcium channel alpha 1G subunit isoform 6 [Homo sapiens] Length = 2306 Score = 99.8 bits (247), Expect = 6e-21 Identities = 68/318 (21%), Positives = 162/318 (50%), Gaps = 40/318 (12%) Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164 +F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K Sbjct: 1254 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1309 Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221 W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++ Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369 Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263 ++ + +++++ L+ +LK + ++++ FF IF + GV +F Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429 Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316 S+ + + + + F +L +L+++F+L + D W ++ D V + + Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489 Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376 +YFI +LL+ + ++ V ++V NF R+ EE ARR + + R++ ++R+ Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL----RRLEKKRR 1545 Query: 377 NMSHEALTSSHSKIEDSS 394 N+ + + +S S +S Sbjct: 1546 NLMLDDVIASGSSASAAS 1563 Score = 92.8 bits (229), Expect = 7e-19 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%) Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200 L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V + Sbjct: 1620 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1679 Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260 ++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV Sbjct: 1680 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1739 Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312 +F + P + L H F + + +T+F + T D+W +++D + + Sbjct: 1740 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1799 Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366 + + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M Sbjct: 1800 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1852 Score = 86.3 bits (212), Expect = 6e-17 Identities = 72/256 (28%), Positives = 131/256 (51%), Gaps = 15/256 (5%) Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152 P S+ A W L C F+ + F I++ + + L P +LT LE++ Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781 Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211 +F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835 Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271 R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895 Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329 L F L ++VTVF + T + W +L + + ++++YFI + G+ Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952 Query: 330 IIFRSIIVAMMVTNFQ 345 + +++VA++V FQ Sbjct: 953 YVLFNLLVAILVEGFQ 968 Score = 49.3 bits (116), Expect = 9e-06 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%) Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206 FI F +E+++K ++ +F K WN DF + + +L + L Q+V Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176 Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266 +R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++ Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236 Query: 267 TRS 269 R+ Sbjct: 237 LRN 239 Score = 37.0 bits (84), Expect = 0.045 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%) Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339 F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + + Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393 Query: 340 MVTNFQNIRKELNEEMARREVQ 361 + T F ++ ++ M + V+ Sbjct: 394 IATQFSETKQRESQLMREQRVR 415 >gi|38505278 voltage-dependent calcium channel alpha 1G subunit isoform 11 [Homo sapiens] Length = 2261 Score = 99.8 bits (247), Expect = 6e-21 Identities = 68/318 (21%), Positives = 162/318 (50%), Gaps = 40/318 (12%) Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164 +F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K Sbjct: 1254 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1309 Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221 W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++ Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369 Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263 ++ + +++++ L+ +LK + ++++ FF IF + GV +F Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429 Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316 S+ + + + + F +L +L+++F+L + D W ++ D V + + Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489 Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376 +YFI +LL+ + ++ V ++V NF R+ EE ARR + + R++ ++R+ Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL----RRLEKKRR 1545 Query: 377 NMSHEALTSSHSKIEDSS 394 N+ + + +S S +S Sbjct: 1546 NLMLDDVIASGSSASAAS 1563 Score = 92.8 bits (229), Expect = 7e-19 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%) Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200 L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V + Sbjct: 1620 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1679 Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260 ++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV Sbjct: 1680 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1739 Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312 +F + P + L H F + + +T+F + T D+W +++D + + Sbjct: 1740 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1799 Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366 + + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M Sbjct: 1800 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1852 Score = 86.3 bits (212), Expect = 6e-17 Identities = 72/256 (28%), Positives = 131/256 (51%), Gaps = 15/256 (5%) Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152 P S+ A W L C F+ + F I++ + + L P +LT LE++ Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781 Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211 +F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835 Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271 R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895 Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329 L F L ++VTVF + T + W +L + + ++++YFI + G+ Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952 Query: 330 IIFRSIIVAMMVTNFQ 345 + +++VA++V FQ Sbjct: 953 YVLFNLLVAILVEGFQ 968 Score = 49.3 bits (116), Expect = 9e-06 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%) Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206 FI F +E+++K ++ +F K WN DF + + +L + L Q+V Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176 Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266 +R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++ Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236 Query: 267 TRS 269 R+ Sbjct: 237 LRN 239 Score = 37.0 bits (84), Expect = 0.045 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%) Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339 F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + + Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393 Query: 340 MVTNFQNIRKELNEEMARREVQ 361 + T F ++ ++ M + V+ Sbjct: 394 IATQFSETKQRESQLMREQRVR 415 >gi|38505270 voltage-dependent calcium channel alpha 1G subunit isoform 2 [Homo sapiens] Length = 2354 Score = 99.8 bits (247), Expect = 6e-21 Identities = 68/318 (21%), Positives = 162/318 (50%), Gaps = 40/318 (12%) Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164 +F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K Sbjct: 1254 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1309 Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221 W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++ Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369 Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263 ++ + +++++ L+ +LK + ++++ FF IF + GV +F Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429 Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316 S+ + + + + F +L +L+++F+L + D W ++ D V + + Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489 Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376 +YFI +LL+ + ++ V ++V NF R+ EE ARR + + R++ ++R+ Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL----RRLEKKRR 1545 Query: 377 NMSHEALTSSHSKIEDSS 394 N+ + + +S S +S Sbjct: 1546 NLMLDDVIASGSSASAAS 1563 Score = 92.8 bits (229), Expect = 7e-19 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%) Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200 L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V + Sbjct: 1620 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1679 Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260 ++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV Sbjct: 1680 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1739 Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312 +F + P + L H F + + +T+F + T D+W +++D + + Sbjct: 1740 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1799 Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366 + + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M Sbjct: 1800 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1852 Score = 86.3 bits (212), Expect = 6e-17 Identities = 72/256 (28%), Positives = 131/256 (51%), Gaps = 15/256 (5%) Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152 P S+ A W L C F+ + F I++ + + L P +LT LE++ Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781 Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211 +F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835 Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271 R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895 Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329 L F L ++VTVF + T + W +L + + ++++YFI + G+ Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952 Query: 330 IIFRSIIVAMMVTNFQ 345 + +++VA++V FQ Sbjct: 953 YVLFNLLVAILVEGFQ 968 Score = 49.3 bits (116), Expect = 9e-06 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%) Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206 FI F +E+++K ++ +F K WN DF + + +L + L Q+V Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176 Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266 +R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++ Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236 Query: 267 TRS 269 R+ Sbjct: 237 LRN 239 Score = 37.0 bits (84), Expect = 0.045 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%) Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339 F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + + Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393 Query: 340 MVTNFQNIRKELNEEMARREVQ 361 + T F ++ ++ M + V+ Sbjct: 394 IATQFSETKQRESQLMREQRVR 415 >gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B subunit [Homo sapiens] Length = 2339 Score = 99.8 bits (247), Expect = 6e-21 Identities = 64/254 (25%), Positives = 129/254 (50%), Gaps = 18/254 (7%) Query: 108 PLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLS 167 P F+ FI+ ++ LNT++LM++ + +L L+ +F +E +LK ++ Sbjct: 1471 PPFEYFIMAMIALNTVVLMMKFY------DAPYEYELMLKCLNIVFTSMFSMECVLKIIA 1524 Query: 168 NFSV--FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFR 225 F V +++ AWNVFDFV + S+ +V + T + L LR+ R R +KLL Q Sbjct: 1525 -FGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGY 1583 Query: 226 QIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPN 285 I+I++ V++ K++ ++ +L+ + F+I+A+ G+ VF + H F Sbjct: 1584 TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQ 1643 Query: 286 SLVTVFILFTLDHWYALL---------QDVWKVPEVSRIFSSIYFILWLLLGSIIFRSII 336 +L+ +F T + W+ ++ + E F+ YF+ ++ L S + ++ Sbjct: 1644 ALMLLFRSATGEAWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLF 1703 Query: 337 VAMMVTNFQNIRKE 350 VA+++ NF+ + ++ Sbjct: 1704 VAVIMDNFEYLTRD 1717 Score = 86.3 bits (212), Expect = 6e-17 Identities = 67/241 (27%), Positives = 125/241 (51%), Gaps = 11/241 (4%) Query: 142 LKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVT 200 L TL A + L +F+ E+ LK +++S++N FDF V + S+ EVV Sbjct: 510 LTTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVF-EVVWAAIKP 568 Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260 G S + +LR R+LR K+ + ++ +++ L+ ++KS+ LL LL +F +FA+ G+ Sbjct: 569 GSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGM 628 Query: 261 YVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALL-QDVWKVPEVSR-IFSS 318 +F QD F P +++TVF + T + W A++ + VS+ +FSS Sbjct: 629 QLFGGQFNF--QDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSS 686 Query: 319 IYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRKNM 378 YFI+ L G+ ++ +A+ V N N +E+ + E +++ ++ +Q+ K + Sbjct: 687 FYFIVLTLFGNYTLLNVFLAIAVDNLANA-----QELTKDEEEMEEAANQKLALQKAKEV 741 Query: 379 S 379 + Sbjct: 742 A 742 Score = 72.0 bits (175), Expect = 1e-12 Identities = 84/395 (21%), Positives = 161/395 (40%), Gaps = 69/395 (17%) Query: 100 WAGWVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFIL 159 +A + E P F+ I+ + N I+L +E L + T P+ L+ + + IF Sbjct: 87 YAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKT---PMSERLDDTEPYFIGIFCF 143 Query: 160 EILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRV 214 E +K ++ VF K + WNV DFVV + +L G L+ LR RV Sbjct: 144 EAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGIL-------ATAGTDFDLRTLRAVRV 196 Query: 215 LRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF----------- 263 LR LKL++ +Q+++ +++A+ + + +LL +FA+ G+ + Sbjct: 197 LRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPN 256 Query: 264 ---------------------------SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTL 296 EY P + F ++ +++TVF T+ Sbjct: 257 STDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGI---TNFDNILFAILTVFQCITM 313 Query: 297 DHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMA 356 + W +L + ++ +YFI +++GS ++++ ++ F R+ + A Sbjct: 314 EGWTDILYNT--NDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRA 371 Query: 357 ----RREVQLKADM--FKRQIIQRRKNMSHEALTSSHSKIE-DSSRGASQQRESLDLSEV 409 RR+ Q++ ++ + I + + M E ++ K D + A+ ++ DL Sbjct: 372 FLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHA 431 Query: 410 SEVESNYGATEEDLITSASKTEETLSKKREYQSSS 444 E E + DL S K + +SSS Sbjct: 432 EEGEDRFA----DLCAVGSPFARASLKSGKTESSS 462 Score = 70.1 bits (170), Expect = 5e-12 Identities = 66/329 (20%), Positives = 146/329 (44%), Gaps = 54/329 (16%) Query: 103 WVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEIL 162 +++ F+ I+ ++ L++I L E + + P L+ + +F E++ Sbjct: 1145 YIVTMRYFEVVILVVIALSSIALAAEDPVRTDS-----PRNNALKYLDYIFTGVFTFEMV 1199 Query: 163 LKWLS-----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQLLRICRVLR 216 +K + + +++ WN+ DF+V +L+ G G+ + ++ LR+ RVLR Sbjct: 1200 IKMIDLGLLLHPGAYFRDLWNILDFIVVSGALV--AFAFSGSKGKDINTIKSLRVLRVLR 1257 Query: 217 SLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------- 263 LK + + +++ + +V +LK++ +L++ ++F +IFAV V +F Sbjct: 1258 PLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKE 1317 Query: 264 --------------SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKV 309 E PRQ +Y + ++ +L+T+F + T + W +L+ Sbjct: 1318 LERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDA 1377 Query: 310 PEVS-------RIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ----NIRKELNEEMARR 358 R+ SI+++++ ++ F +I VA+++ FQ + E + E R Sbjct: 1378 TYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNER 1437 Query: 359 ---EVQLKADMFKRQIIQRRKNMSHEALT 384 + + A R + Q R++ ++ T Sbjct: 1438 ACIDFAISAKPLTRYMPQNRQSFQYKTWT 1466 >gi|62988334 cation channel, sperm associated 4 [Homo sapiens] Length = 472 Score = 98.2 bits (243), Expect = 2e-20 Identities = 64/248 (25%), Positives = 126/248 (50%), Gaps = 22/248 (8%) Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163 +L P F+ + L+ +N I + + + K + L T++ +L I + E+LL Sbjct: 88 LLRHPAFQLLLALLLVINAITIALRTN--SYLDQKHYELFSTIDD---IVLTILLCEVLL 142 Query: 164 KWLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQ 223 WL+ F +FWK WN+ +F++ + LL + + + + L+ LR+ V +++ LA+ Sbjct: 143 GWLNGFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLAR 202 Query: 224 FRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDL 283 II V+++++ M +++L+L F +F+V GV +F + P+ F ++ Sbjct: 203 ------IIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFV--PKH-------FQNI 247 Query: 284 PNSLVTVFILFTLDHWYALLQD--VWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMV 341 +L T+FI T D W + D K I +IYF +++ +G+ I ++ V ++ Sbjct: 248 QVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVT 307 Query: 342 TNFQNIRK 349 TN + + K Sbjct: 308 TNLEQMMK 315 >gi|38505292 voltage-dependent calcium channel alpha 1G subunit isoform 3 [Homo sapiens] Length = 2343 Score = 97.8 bits (242), Expect = 2e-20 Identities = 64/303 (21%), Positives = 153/303 (50%), Gaps = 36/303 (11%) Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164 +F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K Sbjct: 1254 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1309 Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221 W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++ Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369 Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263 ++ + +++++ L+ +LK + ++++ FF IF + GV +F Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429 Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316 S+ + + + + F +L +L+++F+L + D W ++ D V + + Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489 Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376 +YFI +LL+ + ++ V ++V NF R+ EE ARR + + +++ + K Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEK 1549 Query: 377 NMS 379 M+ Sbjct: 1550 QMA 1552 Score = 92.8 bits (229), Expect = 7e-19 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%) Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200 L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V + Sbjct: 1609 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1668 Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260 ++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV Sbjct: 1669 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1728 Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312 +F + P + L H F + + +T+F + T D+W +++D + + Sbjct: 1729 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1788 Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366 + + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M Sbjct: 1789 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1841 Score = 86.3 bits (212), Expect = 6e-17 Identities = 72/256 (28%), Positives = 131/256 (51%), Gaps = 15/256 (5%) Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152 P S+ A W L C F+ + F I++ + + L P +LT LE++ Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781 Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211 +F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835 Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271 R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895 Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329 L F L ++VTVF + T + W +L + + ++++YFI + G+ Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952 Query: 330 IIFRSIIVAMMVTNFQ 345 + +++VA++V FQ Sbjct: 953 YVLFNLLVAILVEGFQ 968 Score = 49.3 bits (116), Expect = 9e-06 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%) Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206 FI F +E+++K ++ +F K WN DF + + +L + L Q+V Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176 Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266 +R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++ Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236 Query: 267 TRS 269 R+ Sbjct: 237 LRN 239 Score = 37.0 bits (84), Expect = 0.045 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%) Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339 F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + + Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393 Query: 340 MVTNFQNIRKELNEEMARREVQ 361 + T F ++ ++ M + V+ Sbjct: 394 IATQFSETKQRESQLMREQRVR 415 >gi|38505288 voltage-dependent calcium channel alpha 1G subunit isoform 12 [Homo sapiens] Length = 2250 Score = 97.8 bits (242), Expect = 2e-20 Identities = 64/303 (21%), Positives = 153/303 (50%), Gaps = 36/303 (11%) Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164 +F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K Sbjct: 1254 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1309 Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221 W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++ Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369 Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263 ++ + +++++ L+ +LK + ++++ FF IF + GV +F Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429 Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316 S+ + + + + F +L +L+++F+L + D W ++ D V + + Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489 Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376 +YFI +LL+ + ++ V ++V NF R+ EE ARR + + +++ + K Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEK 1549 Query: 377 NMS 379 M+ Sbjct: 1550 QMA 1552 Score = 92.8 bits (229), Expect = 7e-19 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%) Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200 L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V + Sbjct: 1609 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1668 Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260 ++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV Sbjct: 1669 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1728 Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312 +F + P + L H F + + +T+F + T D+W +++D + + Sbjct: 1729 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1788 Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366 + + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M Sbjct: 1789 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1841 Score = 86.3 bits (212), Expect = 6e-17 Identities = 72/256 (28%), Positives = 131/256 (51%), Gaps = 15/256 (5%) Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152 P S+ A W L C F+ + F I++ + + L P +LT LE++ Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781 Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211 +F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835 Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271 R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895 Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329 L F L ++VTVF + T + W +L + + ++++YFI + G+ Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952 Query: 330 IIFRSIIVAMMVTNFQ 345 + +++VA++V FQ Sbjct: 953 YVLFNLLVAILVEGFQ 968 Score = 49.3 bits (116), Expect = 9e-06 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%) Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206 FI F +E+++K ++ +F K WN DF + + +L + L Q+V Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176 Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266 +R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++ Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236 Query: 267 TRS 269 R+ Sbjct: 237 LRN 239 Score = 37.0 bits (84), Expect = 0.045 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%) Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339 F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + + Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393 Query: 340 MVTNFQNIRKELNEEMARREVQ 361 + T F ++ ++ M + V+ Sbjct: 394 IATQFSETKQRESQLMREQRVR 415 >gi|38505276 voltage-dependent calcium channel alpha 1G subunit isoform 5 [Homo sapiens] Length = 2321 Score = 97.8 bits (242), Expect = 2e-20 Identities = 64/303 (21%), Positives = 153/303 (50%), Gaps = 36/303 (11%) Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164 +F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K Sbjct: 1277 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1332 Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221 W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++ Sbjct: 1333 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1392 Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263 ++ + +++++ L+ +LK + ++++ FF IF + GV +F Sbjct: 1393 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1452 Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316 S+ + + + + F +L +L+++F+L + D W ++ D V + + Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512 Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376 +YFI +LL+ + ++ V ++V NF R+ EE ARR + + +++ + K Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEK 1572 Query: 377 NMS 379 M+ Sbjct: 1573 QMA 1575 Score = 92.8 bits (229), Expect = 7e-19 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%) Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200 L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V + Sbjct: 1632 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1691 Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260 ++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV Sbjct: 1692 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1751 Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312 +F + P + L H F + + +T+F + T D+W +++D + + Sbjct: 1752 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1811 Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366 + + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M Sbjct: 1812 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1864 Score = 88.2 bits (217), Expect = 2e-17 Identities = 76/270 (28%), Positives = 138/270 (51%), Gaps = 21/270 (7%) Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152 P S+ A W L C F+ + F I++ + + L P +LT LE++ Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781 Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211 +F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835 Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271 R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895 Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329 L F L ++VTVF + T + W +L + + ++++YFI + G+ Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952 Query: 330 IIFRSIIVAMMVTNFQNIRKELNEEMARRE 359 + +++VA++V FQ EE+++RE Sbjct: 953 YVLFNLLVAILVEGFQ------AEEISKRE 976 Score = 49.3 bits (116), Expect = 9e-06 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%) Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206 FI F +E+++K ++ +F K WN DF + + +L + L Q+V Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176 Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266 +R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++ Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236 Query: 267 TRS 269 R+ Sbjct: 237 LRN 239 Score = 37.0 bits (84), Expect = 0.045 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%) Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339 F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + + Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393 Query: 340 MVTNFQNIRKELNEEMARREVQ 361 + T F ++ ++ M + V+ Sbjct: 394 IATQFSETKQRESQLMREQRVR 415 >gi|38505274 voltage-dependent calcium channel alpha 1G subunit isoform 7 [Homo sapiens] Length = 2298 Score = 97.8 bits (242), Expect = 2e-20 Identities = 64/303 (21%), Positives = 153/303 (50%), Gaps = 36/303 (11%) Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164 +F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K Sbjct: 1254 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1309 Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221 W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++ Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369 Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263 ++ + +++++ L+ +LK + ++++ FF IF + GV +F Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429 Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316 S+ + + + + F +L +L+++F+L + D W ++ D V + + Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489 Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376 +YFI +LL+ + ++ V ++V NF R+ EE ARR + + +++ + K Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEK 1549 Query: 377 NMS 379 M+ Sbjct: 1550 QMA 1552 Score = 92.8 bits (229), Expect = 7e-19 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%) Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200 L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V + Sbjct: 1609 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1668 Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260 ++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV Sbjct: 1669 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1728 Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312 +F + P + L H F + + +T+F + T D+W +++D + + Sbjct: 1729 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1788 Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366 + + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M Sbjct: 1789 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1841 Score = 86.3 bits (212), Expect = 6e-17 Identities = 72/256 (28%), Positives = 131/256 (51%), Gaps = 15/256 (5%) Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152 P S+ A W L C F+ + F I++ + + L P +LT LE++ Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781 Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211 +F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835 Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271 R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895 Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329 L F L ++VTVF + T + W +L + + ++++YFI + G+ Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952 Query: 330 IIFRSIIVAMMVTNFQ 345 + +++VA++V FQ Sbjct: 953 YVLFNLLVAILVEGFQ 968 Score = 49.3 bits (116), Expect = 9e-06 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%) Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206 FI F +E+++K ++ +F K WN DF + + +L + L Q+V Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176 Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266 +R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++ Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236 Query: 267 TRS 269 R+ Sbjct: 237 LRN 239 Score = 37.0 bits (84), Expect = 0.045 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%) Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339 F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + + Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393 Query: 340 MVTNFQNIRKELNEEMARREVQ 361 + T F ++ ++ M + V+ Sbjct: 394 IATQFSETKQRESQLMREQRVR 415 >gi|38505272 voltage-dependent calcium channel alpha 1G subunit isoform 9 [Homo sapiens] Length = 2273 Score = 97.8 bits (242), Expect = 2e-20 Identities = 64/303 (21%), Positives = 153/303 (50%), Gaps = 36/303 (11%) Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164 +F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K Sbjct: 1277 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1332 Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221 W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++ Sbjct: 1333 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1392 Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263 ++ + +++++ L+ +LK + ++++ FF IF + GV +F Sbjct: 1393 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1452 Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316 S+ + + + + F +L +L+++F+L + D W ++ D V + + Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512 Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376 +YFI +LL+ + ++ V ++V NF R+ EE ARR + + +++ + K Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEK 1572 Query: 377 NMS 379 M+ Sbjct: 1573 QMA 1575 Score = 92.8 bits (229), Expect = 7e-19 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%) Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200 L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V + Sbjct: 1632 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1691 Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260 ++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV Sbjct: 1692 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1751 Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312 +F + P + L H F + + +T+F + T D+W +++D + + Sbjct: 1752 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1811 Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366 + + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M Sbjct: 1812 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1864 Score = 88.2 bits (217), Expect = 2e-17 Identities = 76/270 (28%), Positives = 138/270 (51%), Gaps = 21/270 (7%) Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152 P S+ A W L C F+ + F I++ + + L P +LT LE++ Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781 Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211 +F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835 Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271 R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895 Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329 L F L ++VTVF + T + W +L + + ++++YFI + G+ Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952 Query: 330 IIFRSIIVAMMVTNFQNIRKELNEEMARRE 359 + +++VA++V FQ EE+++RE Sbjct: 953 YVLFNLLVAILVEGFQ------AEEISKRE 976 Score = 49.3 bits (116), Expect = 9e-06 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%) Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206 FI F +E+++K ++ +F K WN DF + + +L + L Q+V Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176 Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266 +R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++ Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236 Query: 267 TRS 269 R+ Sbjct: 237 LRN 239 Score = 37.0 bits (84), Expect = 0.045 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%) Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339 F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + + Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393 Query: 340 MVTNFQNIRKELNEEMARREVQ 361 + T F ++ ++ M + V+ Sbjct: 394 IATQFSETKQRESQLMREQRVR 415 >gi|38505268 voltage-dependent calcium channel alpha 1G subunit isoform 14 [Homo sapiens] Length = 2171 Score = 97.8 bits (242), Expect = 2e-20 Identities = 64/303 (21%), Positives = 153/303 (50%), Gaps = 36/303 (11%) Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164 +F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K Sbjct: 1254 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1309 Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221 W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++ Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369 Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263 ++ + +++++ L+ +LK + ++++ FF IF + GV +F Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429 Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316 S+ + + + + F +L +L+++F+L + D W ++ D V + + Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489 Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376 +YFI +LL+ + ++ V ++V NF R+ EE ARR + + +++ + K Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEK 1549 Query: 377 NMS 379 M+ Sbjct: 1550 QMA 1552 Score = 92.8 bits (229), Expect = 7e-19 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%) Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200 L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V + Sbjct: 1609 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1668 Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260 ++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV Sbjct: 1669 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1728 Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312 +F + P + L H F + + +T+F + T D+W +++D + + Sbjct: 1729 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1788 Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366 + + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M Sbjct: 1789 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1841 Score = 86.3 bits (212), Expect = 6e-17 Identities = 72/256 (28%), Positives = 131/256 (51%), Gaps = 15/256 (5%) Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152 P S+ A W L C F+ + F I++ + + L P +LT LE++ Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781 Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211 +F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835 Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271 R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895 Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329 L F L ++VTVF + T + W +L + + ++++YFI + G+ Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952 Query: 330 IIFRSIIVAMMVTNFQ 345 + +++VA++V FQ Sbjct: 953 YVLFNLLVAILVEGFQ 968 Score = 49.3 bits (116), Expect = 9e-06 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%) Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206 FI F +E+++K ++ +F K WN DF + + +L + L Q+V Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176 Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266 +R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++ Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236 Query: 267 TRS 269 R+ Sbjct: 237 LRN 239 Score = 37.0 bits (84), Expect = 0.045 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%) Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339 F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + + Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393 Query: 340 MVTNFQNIRKELNEEMARREVQ 361 + T F ++ ++ M + V+ Sbjct: 394 IATQFSETKQRESQLMREQRVR 415 >gi|38505290 voltage-dependent calcium channel alpha 1G subunit isoform 13 [Homo sapiens] Length = 2243 Score = 96.7 bits (239), Expect = 5e-20 Identities = 66/313 (21%), Positives = 158/313 (50%), Gaps = 40/313 (12%) Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164 +F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K Sbjct: 1254 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1309 Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221 W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++ Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369 Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263 ++ + +++++ L+ +LK + ++++ FF IF + GV +F Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429 Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316 S+ + + + + F +L +L+++F+L + D W ++ D V + + Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489 Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376 +YFI +LL+ + ++ V ++V NF R+ EE ARR + + R++ ++R+ Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL----RRLEKKRR 1545 Query: 377 NMSHEALTSSHSK 389 + S +S+ Sbjct: 1546 KAQCKPYYSDYSR 1558 Score = 92.8 bits (229), Expect = 7e-19 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%) Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200 L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V + Sbjct: 1602 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1661 Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260 ++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV Sbjct: 1662 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1721 Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312 +F + P + L H F + + +T+F + T D+W +++D + + Sbjct: 1722 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1781 Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366 + + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M Sbjct: 1782 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1834 Score = 86.3 bits (212), Expect = 6e-17 Identities = 72/256 (28%), Positives = 131/256 (51%), Gaps = 15/256 (5%) Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152 P S+ A W L C F+ + F I++ + + L P +LT LE++ Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781 Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211 +F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835 Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271 R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895 Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329 L F L ++VTVF + T + W +L + + ++++YFI + G+ Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952 Query: 330 IIFRSIIVAMMVTNFQ 345 + +++VA++V FQ Sbjct: 953 YVLFNLLVAILVEGFQ 968 Score = 49.3 bits (116), Expect = 9e-06 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%) Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206 FI F +E+++K ++ +F K WN DF + + +L + L Q+V Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176 Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266 +R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++ Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236 Query: 267 TRS 269 R+ Sbjct: 237 LRN 239 Score = 37.0 bits (84), Expect = 0.045 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%) Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339 F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + + Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393 Query: 340 MVTNFQNIRKELNEEMARREVQ 361 + T F ++ ++ M + V+ Sbjct: 394 IATQFSETKQRESQLMREQRVR 415 >gi|38505286 voltage-dependent calcium channel alpha 1G subunit isoform 10 [Homo sapiens] Length = 2266 Score = 96.7 bits (239), Expect = 5e-20 Identities = 66/313 (21%), Positives = 158/313 (50%), Gaps = 40/313 (12%) Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK---- 164 +F + ++ ++FLN I + +E ++ + + ++ L ++ + +F+ E+ +K Sbjct: 1277 MFDHVVLVIIFLNCITIAMERPKIDPHSAE----RIFLTLSNYIFTAVFLAEMTVKVVAL 1332 Query: 165 -WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV--WLQLLRICRVLRSLKLL 221 W + +S+WNV D ++ ++S++ +V +V +G + L++LR+ R LR L+++ Sbjct: 1333 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1392 Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------------------ 263 ++ + +++++ L+ +LK + ++++ FF IF + GV +F Sbjct: 1393 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1452 Query: 264 SEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI-------F 316 S+ + + + + F +L +L+++F+L + D W ++ D V + + Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512 Query: 317 SSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRK 376 +YFI +LL+ + ++ V ++V NF R+ EE ARR + + R++ ++R+ Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRL----RRLEKKRR 1568 Query: 377 NMSHEALTSSHSK 389 + S +S+ Sbjct: 1569 KAQCKPYYSDYSR 1581 Score = 92.8 bits (229), Expect = 7e-19 Identities = 58/234 (24%), Positives = 123/234 (52%), Gaps = 14/234 (5%) Query: 146 LEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSL----LPEVVVLVGVT 200 L++ + +IF+LE + K ++ F F++ WN D + +LS+ L E+ V + Sbjct: 1625 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1684 Query: 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260 ++++R+ R+ R LKLL ++ ++ +++AL + L +L ++ F+IFA GV Sbjct: 1685 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1744 Query: 261 YVFSEY---TRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPE-----V 312 +F + P + L H F + + +T+F + T D+W +++D + + Sbjct: 1745 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1804 Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADM 366 + + S IYF+ ++L + ++++A+++ + + KE EE A E +L+ +M Sbjct: 1805 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE-AELEAELELEM 1857 Score = 88.2 bits (217), Expect = 2e-17 Identities = 76/270 (28%), Positives = 138/270 (51%), Gaps = 21/270 (7%) Query: 96 PLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLE-STNTKLWPLKLT--LEVAAWF 152 P S+ A W L C F+ + F I++ + + L P +LT LE++ Sbjct: 722 PSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 781 Query: 153 ILLIFILEILLKWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRI 211 +F LE+LLK L + K+ +N+FD V+ ++S V +VG G L +LR Sbjct: 782 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS----VWEIVGQQGGG--LSVLRT 835 Query: 212 CRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPR 271 R++R LKL+ +Q ++VL++ + ++ MLL++F +IF++ G+++F S R Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895 Query: 272 --QDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 329 L F L ++VTVF + T + W +L + + ++++YFI + G+ Sbjct: 896 DGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL---YNGMASTSSWAALYFIALMTFGN 952 Query: 330 IIFRSIIVAMMVTNFQNIRKELNEEMARRE 359 + +++VA++V FQ EE+++RE Sbjct: 953 YVLFNLLVAILVEGFQ------AEEISKRE 976 Score = 49.3 bits (116), Expect = 9e-06 Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%) Query: 152 FILLIFILEILLKWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVVLVGVTGQSVWL 206 FI F +E+++K ++ +F K WN DF + + +L + L Q+V Sbjct: 123 FIFAFFAVEMVVKMVA-LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDL-----QNVSF 176 Query: 207 QLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY 266 +R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV +++ Sbjct: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236 Query: 267 TRS 269 R+ Sbjct: 237 LRN 239 Score = 37.0 bits (84), Expect = 0.045 Identities = 17/82 (20%), Positives = 44/82 (53%), Gaps = 3/82 (3%) Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339 F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + + Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIM---YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 393 Query: 340 MVTNFQNIRKELNEEMARREVQ 361 + T F ++ ++ M + V+ Sbjct: 394 IATQFSETKQRESQLMREQRVR 415 >gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H subunit isoform b [Homo sapiens] Length = 2347 Score = 95.5 bits (236), Expect = 1e-19 Identities = 67/272 (24%), Positives = 136/272 (50%), Gaps = 27/272 (9%) Query: 113 FIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSV 171 FI F++ +N I + +E + L L+ + ++F+ E LK ++ F Sbjct: 1616 FITFIICVNVITMSMEHYNQPKS------LDEALKYCNYVFTIVFVFEAALKLVAFGFRR 1669 Query: 172 FWKSAWNVFDFVVTMLSL----LPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQI 227 F+K WN D + +LSL L E+ + + ++++R+ R+ R LKLL + Sbjct: 1670 FFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGM 1729 Query: 228 QIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRS---PRQDLEYHVFFSDLP 284 + ++ +V+AL + L +L ++ F+I+A GV +F S P + L H FS+ Sbjct: 1730 RALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFG 1789 Query: 285 NSLVTVFILFTLDHWYALLQDVWKVPEVSR----------IFSSIYFILWLLLGSIIFRS 334 + +T+F + T D+W +++D + E SR S +YF+ ++L+ + + Sbjct: 1790 MAFLTLFRVSTGDNWNGIMKDTLR--ECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVN 1847 Query: 335 IIVAMMVTNFQNIRKELNEEMARREVQLKADM 366 ++VA+++ + + KE E+ A + +++ +M Sbjct: 1848 VVVAVLMKHLEESNKEARED-AELDAEIELEM 1878 Score = 93.6 bits (231), Expect = 4e-19 Identities = 72/306 (23%), Positives = 153/306 (50%), Gaps = 38/306 (12%) Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163 V+ +F + ++ +FLN + + +E ++ +T+ ++ L V+ + IF+ E+++ Sbjct: 1290 VITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTE----RVFLSVSNYIFTAIFVAEMMV 1345 Query: 164 K-----WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVW--LQLLRICRVLR 216 K LS + +S+WN+ D ++ ++SL+ VV + G + L++LR+ R LR Sbjct: 1346 KVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLR 1405 Query: 217 SLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY---------- 266 L+++++ +++++ L+ +L+ + ++++ FF IF + GV +F Sbjct: 1406 PLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTR 1465 Query: 267 ---TRSPRQDLEYHVF-----FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI--- 315 T++ + Y F +L +L+++F+L + D W ++ D V + Sbjct: 1466 NISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQ 1525 Query: 316 ----FSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARR--EVQLKADMFKR 369 + +YFI +LL+ S ++ V ++V NF R+ E ARR E +L+ +R Sbjct: 1526 NHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRR 1585 Query: 370 QIIQRR 375 + QRR Sbjct: 1586 RKAQRR 1591 Score = 74.3 bits (181), Expect = 3e-13 Identities = 58/247 (23%), Positives = 124/247 (50%), Gaps = 21/247 (8%) Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163 +++ F I+ + +NT+ + VE T LE++ +F LE+LL Sbjct: 789 IVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTN------ALEISNIVFTSMFALEMLL 842 Query: 164 KWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVW-LQLLRICRVLRSLKLL 221 K L+ + + ++ +N+FD ++ ++S+ + GQ+ L +LR R+LR LKL+ Sbjct: 843 KLLACGPLGYIRNPYNIFDGIIVVISVWE-------IVGQADGGLSVLRTFRLLRVLKLV 895 Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFS---EYTRSPRQDLEYHV 278 ++ ++VLV+ + ++ LL++F +IF++ G+++F + Sbjct: 896 RFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRK 955 Query: 279 FFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVA 338 F L ++VTVF + T + W +L + + ++++YF+ + G+ + +++VA Sbjct: 956 NFDSLLWAIVTVFQILTQEDWNVVL---YNGMASTSSWAALYFVALMTFGNYVLFNLLVA 1012 Query: 339 MMVTNFQ 345 ++V FQ Sbjct: 1013 ILVEGFQ 1019 Score = 50.8 bits (120), Expect = 3e-06 Identities = 31/128 (24%), Positives = 63/128 (49%), Gaps = 9/128 (7%) Query: 146 LEVAAWFILLIFILEILLKWLS----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTG 201 LE FI F +E+++K ++ + WN DF + + ++ + G Sbjct: 136 LEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMME-----YSLDG 190 Query: 202 QSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVY 261 +V L +R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV Sbjct: 191 HNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQ 250 Query: 262 VFSEYTRS 269 +++ R+ Sbjct: 251 LWAGLLRN 258 Score = 38.9 bits (89), Expect = 0.012 Identities = 25/110 (22%), Positives = 56/110 (50%), Gaps = 18/110 (16%) Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339 F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + + Sbjct: 361 FDNIGYAWIAIFQVITLEGWVDIM---YYVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 417 Query: 340 MVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSK 389 + T F E +RE QL + QR +++S+++ +S S+ Sbjct: 418 IATQF--------SETKQRESQLMRE-------QRARHLSNDSTLASFSE 452 >gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H subunit isoform a [Homo sapiens] Length = 2353 Score = 95.5 bits (236), Expect = 1e-19 Identities = 67/272 (24%), Positives = 136/272 (50%), Gaps = 27/272 (9%) Query: 113 FIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSV 171 FI F++ +N I + +E + L L+ + ++F+ E LK ++ F Sbjct: 1622 FITFIICVNVITMSMEHYNQPKS------LDEALKYCNYVFTIVFVFEAALKLVAFGFRR 1675 Query: 172 FWKSAWNVFDFVVTMLSL----LPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQI 227 F+K WN D + +LSL L E+ + + ++++R+ R+ R LKLL + Sbjct: 1676 FFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGM 1735 Query: 228 QIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRS---PRQDLEYHVFFSDLP 284 + ++ +V+AL + L +L ++ F+I+A GV +F S P + L H FS+ Sbjct: 1736 RALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFG 1795 Query: 285 NSLVTVFILFTLDHWYALLQDVWKVPEVSR----------IFSSIYFILWLLLGSIIFRS 334 + +T+F + T D+W +++D + E SR S +YF+ ++L+ + + Sbjct: 1796 MAFLTLFRVSTGDNWNGIMKDTLR--ECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVN 1853 Query: 335 IIVAMMVTNFQNIRKELNEEMARREVQLKADM 366 ++VA+++ + + KE E+ A + +++ +M Sbjct: 1854 VVVAVLMKHLEESNKEARED-AELDAEIELEM 1884 Score = 92.4 bits (228), Expect = 9e-19 Identities = 67/299 (22%), Positives = 148/299 (49%), Gaps = 36/299 (12%) Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163 V+ +F + ++ +FLN + + +E ++ +T+ ++ L V+ + IF+ E+++ Sbjct: 1290 VITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTE----RVFLSVSNYIFTAIFVAEMMV 1345 Query: 164 K-----WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVW--LQLLRICRVLR 216 K LS + +S+WN+ D ++ ++SL+ VV + G + L++LR+ R LR Sbjct: 1346 KVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLR 1405 Query: 217 SLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEY---------- 266 L+++++ +++++ L+ +L+ + ++++ FF IF + GV +F Sbjct: 1406 PLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTR 1465 Query: 267 ---TRSPRQDLEYHVF-----FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRI--- 315 T++ + Y F +L +L+++F+L + D W ++ D V + Sbjct: 1466 NISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQ 1525 Query: 316 ----FSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQ 370 + +YFI +LL+ S ++ V ++V NF R+ E ARR + + +R+ Sbjct: 1526 NHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERR 1584 Score = 74.3 bits (181), Expect = 3e-13 Identities = 58/247 (23%), Positives = 124/247 (50%), Gaps = 21/247 (8%) Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163 +++ F I+ + +NT+ + VE T LE++ +F LE+LL Sbjct: 789 IVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTN------ALEISNIVFTSMFALEMLL 842 Query: 164 KWLSNFSV-FWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVW-LQLLRICRVLRSLKLL 221 K L+ + + ++ +N+FD ++ ++S+ + GQ+ L +LR R+LR LKL+ Sbjct: 843 KLLACGPLGYIRNPYNIFDGIIVVISVWE-------IVGQADGGLSVLRTFRLLRVLKLV 895 Query: 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFS---EYTRSPRQDLEYHV 278 ++ ++VLV+ + ++ LL++F +IF++ G+++F + Sbjct: 896 RFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRK 955 Query: 279 FFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVA 338 F L ++VTVF + T + W +L + + ++++YF+ + G+ + +++VA Sbjct: 956 NFDSLLWAIVTVFQILTQEDWNVVL---YNGMASTSSWAALYFVALMTFGNYVLFNLLVA 1012 Query: 339 MMVTNFQ 345 ++V FQ Sbjct: 1013 ILVEGFQ 1019 Score = 50.8 bits (120), Expect = 3e-06 Identities = 31/128 (24%), Positives = 63/128 (49%), Gaps = 9/128 (7%) Query: 146 LEVAAWFILLIFILEILLKWLS----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTG 201 LE FI F +E+++K ++ + WN DF + + ++ + G Sbjct: 136 LEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMME-----YSLDG 190 Query: 202 QSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVY 261 +V L +R RVLR L+ + + ++I++ +L+ L + +L+L F+IF + GV Sbjct: 191 HNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQ 250 Query: 262 VFSEYTRS 269 +++ R+ Sbjct: 251 LWAGLLRN 258 Score = 38.9 bits (89), Expect = 0.012 Identities = 25/110 (22%), Positives = 56/110 (50%), Gaps = 18/110 (16%) Query: 280 FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAM 339 F ++ + + +F + TL+ W ++ + V + ++ IYFIL +++GS ++ + + Sbjct: 361 FDNIGYAWIAIFQVITLEGWVDIM---YYVMDAHSFYNFIYFILLIIVGSFFMINLCLVV 417 Query: 340 MVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSK 389 + T F E +RE QL + QR +++S+++ +S S+ Sbjct: 418 IATQF--------SETKQRESQLMRE-------QRARHLSNDSTLASFSE 452 >gi|193788732 calcium channel, voltage-dependent, L type, alpha 1C subunit isoform 5 [Homo sapiens] Length = 2166 Score = 94.7 bits (234), Expect = 2e-19 Identities = 102/423 (24%), Positives = 177/423 (41%), Gaps = 46/423 (10%) Query: 85 SRLHVRCSQRPPLSLWAGWVLECP----------LFKNFIIFLVFLNTIILMVEIELLES 134 +RL R S+ W W C +F +IFLVFLNT+ + E Sbjct: 491 ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE-----H 545 Query: 135 TNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEV 193 N W L + A +L +F E+LLK S ++ S +N FD V +L + Sbjct: 546 YNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604 Query: 194 VVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFY 253 +V + + + +LR R+LR K+ + + ++ L+ +++S+ LL+LL +F Sbjct: 605 LVETKIMSP-LGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFII 663 Query: 254 IFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQD---VWKVP 310 IF++ G+ +F F + P SL+TVF + T + W +++ D + P Sbjct: 664 IFSLLGMQLFGGKFNFDEMQTRRSTF-DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722 Query: 311 EVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTN------FQNIRKELNEEMARREVQLKA 364 + IYFI+ + G+ I ++ +A+ V N + +KE EE R+++ A Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782 Query: 365 DMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGAS--------------QQRESLDLSEVS 410 K+Q + + + S KIE S A Q E+ D S Sbjct: 783 SPEKKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYP 838 Query: 411 EVESNYGATEEDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDW 470 E+ EE+ LS+ + + + S+ + SS +RF R+ Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVN 898 Query: 471 ETL 473 +T+ Sbjct: 899 DTI 901 Score = 71.6 bits (174), Expect = 2e-12 Identities = 78/364 (21%), Positives = 152/364 (41%), Gaps = 63/364 (17%) Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163 ++E F+ I+ +F N + L + I E + LE + L+IF +E L Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNAT---NSNLERVEYLFLIIFTVEAFL 176 Query: 164 KWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVV---------LVGVTGQSVWLQLL 209 K ++ +F +A WN+ DF++ ++ L ++ +G G ++ L Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236 Query: 210 RICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------ 263 R RVLR L+L++ +Q+++ +++A+ + + +L+L I+A+ G+ +F Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296 Query: 264 ------------SEYTRSP--------RQ-----------DLEYH--VFFSDLPNSLVTV 290 +E SP RQ D H F + +++TV Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTV 356 Query: 291 FILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350 F T++ W +L W V R + IYF+ +++GS ++++ ++ F KE Sbjct: 357 FQCITMEGWTDVL--YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS---KE 411 Query: 351 LNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGASQQRESLDLSEVS 410 + AR + Q + K+Q+ + K + E+ G +++ S Sbjct: 412 REKAKARGDFQKLRE--KQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTS 469 Query: 411 EVES 414 E ES Sbjct: 470 ETES 473 Score = 71.6 bits (174), Expect = 2e-12 Identities = 60/300 (20%), Positives = 136/300 (45%), Gaps = 52/300 (17%) Query: 103 WVLECPLFKNFIIFLVFLNTIILMVE-----------IELLESTNTKLWPLKLTLEVAAW 151 +V+ F+ + L+ LNTI L ++ + +L T L+ +++ L++ A+ Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF 1273 Query: 152 ------------FILLIFILEILLKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGV 199 F LI I I+ LS + ++ AWN FD ++ + S++ + V Sbjct: 1274 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNP 1333 Query: 200 TGQS-------------VWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLM 246 + + + R+ RV+R +KLL++ I+ ++ +++ +++ ++ + Sbjct: 1334 AEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1393 Query: 247 LLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHW----YAL 302 L+++ F+I+AV G+ VF + + ++ + F P +++ +F T + W A Sbjct: 1394 LIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLAC 1453 Query: 303 LQDVWKVPE------------VSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350 + PE F+ YFI + +L + + ++ VA+++ NF + ++ Sbjct: 1454 MPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD 1513 Score = 51.2 bits (121), Expect = 2e-06 Identities = 57/283 (20%), Positives = 125/283 (44%), Gaps = 59/283 (20%) Query: 109 LFKNFIIFLVFLNTIILMVE--IELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWL 166 +F N I+F + L++I L E ++ N L+ + IF +EI LK Sbjct: 901 IFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTT-------IFTIEIALKMT 953 Query: 167 S-----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQLLRICRVLRSLKL 220 + + F ++ +N+ D +V +SL+ G+ ++ +++LR+ RVLR L+ Sbjct: 954 AYGAFLHKGSFCRNYFNILDLLVVSVSLIS-----FGIQSSAINVVKILRVLRVLRPLRA 1008 Query: 221 LAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE--YTRS--------- 269 + + + ++ ++ + A++++ ++++ + ++FA GV +F YT S Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068 Query: 270 -------------------PRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALL------- 303 PR F ++ +++ +F + T + W LL Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128 Query: 304 -QDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ 345 +D + R+ SI+FI+++++ + +I V ++ FQ Sbjct: 1129 TEDKGPIYNY-RVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1170 >gi|193788730 calcium channel, voltage-dependent, L type, alpha 1C subunit isoform 4 [Homo sapiens] Length = 2173 Score = 94.7 bits (234), Expect = 2e-19 Identities = 102/423 (24%), Positives = 177/423 (41%), Gaps = 46/423 (10%) Query: 85 SRLHVRCSQRPPLSLWAGWVLECP----------LFKNFIIFLVFLNTIILMVEIELLES 134 +RL R S+ W W C +F +IFLVFLNT+ + E Sbjct: 491 ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE-----H 545 Query: 135 TNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEV 193 N W L + A +L +F E+LLK S ++ S +N FD V +L + Sbjct: 546 YNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604 Query: 194 VVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFY 253 +V + + + +LR R+LR K+ + + ++ L+ +++S+ LL+LL +F Sbjct: 605 LVETKIMSP-LGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFII 663 Query: 254 IFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQD---VWKVP 310 IF++ G+ +F F + P SL+TVF + T + W +++ D + P Sbjct: 664 IFSLLGMQLFGGKFNFDEMQTRRSTF-DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722 Query: 311 EVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTN------FQNIRKELNEEMARREVQLKA 364 + IYFI+ + G+ I ++ +A+ V N + +KE EE R+++ A Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782 Query: 365 DMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGAS--------------QQRESLDLSEVS 410 K+Q + + + S KIE S A Q E+ D S Sbjct: 783 SPEKKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYP 838 Query: 411 EVESNYGATEEDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDW 470 E+ EE+ LS+ + + + S+ + SS +RF R+ Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVN 898 Query: 471 ETL 473 +T+ Sbjct: 899 DTI 901 Score = 71.6 bits (174), Expect = 2e-12 Identities = 78/364 (21%), Positives = 152/364 (41%), Gaps = 63/364 (17%) Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163 ++E F+ I+ +F N + L + I E + LE + L+IF +E L Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNAT---NSNLERVEYLFLIIFTVEAFL 176 Query: 164 KWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVV---------LVGVTGQSVWLQLL 209 K ++ +F +A WN+ DF++ ++ L ++ +G G ++ L Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236 Query: 210 RICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------ 263 R RVLR L+L++ +Q+++ +++A+ + + +L+L I+A+ G+ +F Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296 Query: 264 ------------SEYTRSP--------RQ-----------DLEYH--VFFSDLPNSLVTV 290 +E SP RQ D H F + +++TV Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTV 356 Query: 291 FILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350 F T++ W +L W V R + IYF+ +++GS ++++ ++ F KE Sbjct: 357 FQCITMEGWTDVL--YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS---KE 411 Query: 351 LNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGASQQRESLDLSEVS 410 + AR + Q + K+Q+ + K + E+ G +++ S Sbjct: 412 REKAKARGDFQKLRE--KQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTS 469 Query: 411 EVES 414 E ES Sbjct: 470 ETES 473 Score = 68.9 bits (167), Expect = 1e-11 Identities = 53/278 (19%), Positives = 128/278 (46%), Gaps = 36/278 (12%) Query: 103 WVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEIL 162 +V+ F+ + L+ LNTI L ++ + K+ + + +F +E++ Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQ------HYGQSCLFKIAMNILNMLFTGLFTVEMI 1267 Query: 163 LKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQS-------------VWLQL 208 LK ++ ++ AWN FD ++ + S++ + V + + + Sbjct: 1268 LKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITF 1327 Query: 209 LRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTR 268 R+ RV+R +KLL++ I+ ++ +++ +++ ++ +L+++ F+I+AV G+ VF + Sbjct: 1328 FRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL 1387 Query: 269 SPRQDLEYHVFFSDLPNSLVTVFILFTLDHW----YALLQDVWKVPE------------V 312 + ++ + F P +++ +F T + W A + PE Sbjct: 1388 NDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPC 1447 Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350 F+ YFI + +L + + ++ VA+++ NF + ++ Sbjct: 1448 GSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD 1485 Score = 55.1 bits (131), Expect = 2e-07 Identities = 59/281 (20%), Positives = 129/281 (45%), Gaps = 55/281 (19%) Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLS- 167 +F N I+F + L++I L E + ++ T+ + L A + IF LEI+LK + Sbjct: 901 IFTNLILFFILLSSISLAAE-DPVQHTSFR----NHILGNADYVFTSIFTLEIILKMTAY 955 Query: 168 ----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQLLRICRVLRSLKLLA 222 + F ++ +N+ D +V +SL+ G+ ++ +++LR+ RVLR L+ + Sbjct: 956 GAFLHKGSFCRNYFNILDLLVVSVSLIS-----FGIQSSAINVVKILRVLRVLRPLRAIN 1010 Query: 223 QFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE--YTRS----------- 269 + + ++ ++ + A++++ ++++ + ++FA GV +F YT S Sbjct: 1011 RAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECK 1070 Query: 270 -----------------PRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALL--------Q 304 PR F ++ +++ +F + T + W LL + Sbjct: 1071 GNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTE 1130 Query: 305 DVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ 345 D + R+ SI+FI+++++ + +I V ++ FQ Sbjct: 1131 DKGPIYNY-RVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1170 >gi|193788728 calcium channel, voltage-dependent, L type, alpha 1C subunit isoform 3 [Homo sapiens] Length = 2179 Score = 94.7 bits (234), Expect = 2e-19 Identities = 102/423 (24%), Positives = 177/423 (41%), Gaps = 46/423 (10%) Query: 85 SRLHVRCSQRPPLSLWAGWVLECP----------LFKNFIIFLVFLNTIILMVEIELLES 134 +RL R S+ W W C +F +IFLVFLNT+ + E Sbjct: 491 ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE-----H 545 Query: 135 TNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEV 193 N W L + A +L +F E+LLK S ++ S +N FD V +L + Sbjct: 546 YNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604 Query: 194 VVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFY 253 +V + + + +LR R+LR K+ + + ++ L+ +++S+ LL+LL +F Sbjct: 605 LVETKIMSP-LGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFII 663 Query: 254 IFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQD---VWKVP 310 IF++ G+ +F F + P SL+TVF + T + W +++ D + P Sbjct: 664 IFSLLGMQLFGGKFNFDEMQTRRSTF-DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722 Query: 311 EVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTN------FQNIRKELNEEMARREVQLKA 364 + IYFI+ + G+ I ++ +A+ V N + +KE EE R+++ A Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782 Query: 365 DMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGAS--------------QQRESLDLSEVS 410 K+Q + + + S KIE S A Q E+ D S Sbjct: 783 SPEKKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYP 838 Query: 411 EVESNYGATEEDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDW 470 E+ EE+ LS+ + + + S+ + SS +RF R+ Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVN 898 Query: 471 ETL 473 +T+ Sbjct: 899 DTI 901 Score = 71.6 bits (174), Expect = 2e-12 Identities = 78/364 (21%), Positives = 152/364 (41%), Gaps = 63/364 (17%) Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163 ++E F+ I+ +F N + L + I E + LE + L+IF +E L Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNAT---NSNLERVEYLFLIIFTVEAFL 176 Query: 164 KWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVV---------LVGVTGQSVWLQLL 209 K ++ +F +A WN+ DF++ ++ L ++ +G G ++ L Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236 Query: 210 RICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------ 263 R RVLR L+L++ +Q+++ +++A+ + + +L+L I+A+ G+ +F Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296 Query: 264 ------------SEYTRSP--------RQ-----------DLEYH--VFFSDLPNSLVTV 290 +E SP RQ D H F + +++TV Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTV 356 Query: 291 FILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350 F T++ W +L W V R + IYF+ +++GS ++++ ++ F KE Sbjct: 357 FQCITMEGWTDVL--YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS---KE 411 Query: 351 LNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGASQQRESLDLSEVS 410 + AR + Q + K+Q+ + K + E+ G +++ S Sbjct: 412 REKAKARGDFQKLRE--KQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTS 469 Query: 411 EVES 414 E ES Sbjct: 470 ETES 473 Score = 61.6 bits (148), Expect = 2e-09 Identities = 55/300 (18%), Positives = 129/300 (43%), Gaps = 58/300 (19%) Query: 103 WVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEIL 162 +V+ F+ + L+ LNTI L ++ + K+ + + +F +E++ Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQ------HYGQSCLFKIAMNILNMLFTGLFTVEMI 1267 Query: 163 LKWLS-NFSVFWKSAWNVFDFVVTMLSLL-------------------------PEVVVL 196 LK ++ ++ AWN FD ++ + S++ P + VL Sbjct: 1268 LKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMGPSCSHPPLAVL 1327 Query: 197 VGVT----------GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLM 246 + + R+ RV+R +KLL++ I+ ++ +++ +++ ++ + Sbjct: 1328 TAPPVADGFQNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1387 Query: 247 LLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHW----YAL 302 L+++ F+I+AV G+ VF + + ++ + F P +++ +F T + W A Sbjct: 1388 LIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLAC 1447 Query: 303 LQDVWKVPE------------VSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350 + PE F+ YFI + +L + + ++ VA+++ NF + ++ Sbjct: 1448 MPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD 1507 Score = 51.2 bits (121), Expect = 2e-06 Identities = 57/283 (20%), Positives = 125/283 (44%), Gaps = 59/283 (20%) Query: 109 LFKNFIIFLVFLNTIILMVE--IELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWL 166 +F N I+F + L++I L E ++ N L+ + IF +EI LK Sbjct: 901 IFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTT-------IFTIEIALKMT 953 Query: 167 S-----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQLLRICRVLRSLKL 220 + + F ++ +N+ D +V +SL+ G+ ++ +++LR+ RVLR L+ Sbjct: 954 AYGAFLHKGSFCRNYFNILDLLVVSVSLIS-----FGIQSSAINVVKILRVLRVLRPLRA 1008 Query: 221 LAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE--YTRS--------- 269 + + + ++ ++ + A++++ ++++ + ++FA GV +F YT S Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068 Query: 270 -------------------PRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALL------- 303 PR F ++ +++ +F + T + W LL Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128 Query: 304 -QDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ 345 +D + R+ SI+FI+++++ + +I V ++ FQ Sbjct: 1129 TEDKGPIYNY-RVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1170 >gi|193788724 calcium channel, voltage-dependent, L type, alpha 1C subunit isoform 2 [Homo sapiens] Length = 2186 Score = 94.7 bits (234), Expect = 2e-19 Identities = 102/423 (24%), Positives = 177/423 (41%), Gaps = 46/423 (10%) Query: 85 SRLHVRCSQRPPLSLWAGWVLECP----------LFKNFIIFLVFLNTIILMVEIELLES 134 +RL R S+ W W C +F +IFLVFLNT+ + E Sbjct: 491 ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE-----H 545 Query: 135 TNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEV 193 N W L + A +L +F E+LLK S ++ S +N FD V +L + Sbjct: 546 YNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604 Query: 194 VVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFY 253 +V + + + +LR R+LR K+ + + ++ L+ +++S+ LL+LL +F Sbjct: 605 LVETKIMSP-LGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFII 663 Query: 254 IFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQD---VWKVP 310 IF++ G+ +F F + P SL+TVF + T + W +++ D + P Sbjct: 664 IFSLLGMQLFGGKFNFDEMQTRRSTF-DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722 Query: 311 EVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTN------FQNIRKELNEEMARREVQLKA 364 + IYFI+ + G+ I ++ +A+ V N + +KE EE R+++ A Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782 Query: 365 DMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGAS--------------QQRESLDLSEVS 410 K+Q + + + S KIE S A Q E+ D S Sbjct: 783 SPEKKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYP 838 Query: 411 EVESNYGATEEDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDW 470 E+ EE+ LS+ + + + S+ + SS +RF R+ Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVN 898 Query: 471 ETL 473 +T+ Sbjct: 899 DTI 901 Score = 71.6 bits (174), Expect = 2e-12 Identities = 78/364 (21%), Positives = 152/364 (41%), Gaps = 63/364 (17%) Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163 ++E F+ I+ +F N + L + I E + LE + L+IF +E L Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNAT---NSNLERVEYLFLIIFTVEAFL 176 Query: 164 KWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVV---------LVGVTGQSVWLQLL 209 K ++ +F +A WN+ DF++ ++ L ++ +G G ++ L Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236 Query: 210 RICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------ 263 R RVLR L+L++ +Q+++ +++A+ + + +L+L I+A+ G+ +F Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296 Query: 264 ------------SEYTRSP--------RQ-----------DLEYH--VFFSDLPNSLVTV 290 +E SP RQ D H F + +++TV Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTV 356 Query: 291 FILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350 F T++ W +L W V R + IYF+ +++GS ++++ ++ F KE Sbjct: 357 FQCITMEGWTDVL--YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS---KE 411 Query: 351 LNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGASQQRESLDLSEVS 410 + AR + Q + K+Q+ + K + E+ G +++ S Sbjct: 412 REKAKARGDFQKLRE--KQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTS 469 Query: 411 EVES 414 E ES Sbjct: 470 ETES 473 Score = 71.6 bits (174), Expect = 2e-12 Identities = 60/300 (20%), Positives = 136/300 (45%), Gaps = 52/300 (17%) Query: 103 WVLECPLFKNFIIFLVFLNTIILMVE-----------IELLESTNTKLWPLKLTLEVAAW 151 +V+ F+ + L+ LNTI L ++ + +L T L+ +++ L++ A+ Sbjct: 1234 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF 1293 Query: 152 ------------FILLIFILEILLKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGV 199 F LI I I+ LS + ++ AWN FD ++ + S++ + V Sbjct: 1294 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNP 1353 Query: 200 TGQS-------------VWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLM 246 + + + R+ RV+R +KLL++ I+ ++ +++ +++ ++ + Sbjct: 1354 AEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1413 Query: 247 LLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHW----YAL 302 L+++ F+I+AV G+ VF + + ++ + F P +++ +F T + W A Sbjct: 1414 LIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLAC 1473 Query: 303 LQDVWKVPE------------VSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350 + PE F+ YFI + +L + + ++ VA+++ NF + ++ Sbjct: 1474 MPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD 1533 Score = 55.8 bits (133), Expect = 9e-08 Identities = 59/296 (19%), Positives = 133/296 (44%), Gaps = 65/296 (21%) Query: 109 LFKNFIIFLVFLNTIILMVE------------IELLESTNTKLWPLKLTLEV---AAWFI 153 +F N I+F + L++I L E + + T ++ +++ L++ A + Sbjct: 901 IFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVF 960 Query: 154 LLIFILEILLKWLS-----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQ 207 IF LEI+LK + + F ++ +N+ D +V +SL+ G+ ++ ++ Sbjct: 961 TSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLIS-----FGIQSSAINVVK 1015 Query: 208 LLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE-- 265 +LR+ RVLR L+ + + + ++ ++ + A++++ ++++ + ++FA GV +F Sbjct: 1016 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1075 Query: 266 YTRS----------------------------PRQDLEYHVFFSDLPNSLVTVFILFTLD 297 YT S PR F ++ +++ +F + T + Sbjct: 1076 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1135 Query: 298 HWYALL--------QDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ 345 W LL +D + R+ SI+FI+++++ + +I V ++ FQ Sbjct: 1136 GWPELLYRSIDSHTEDKGPIYNY-RVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1190 >gi|193788720 calcium channel, voltage-dependent, L type, alpha 1C subunit isoform 1 [Homo sapiens] Length = 2221 Score = 94.7 bits (234), Expect = 2e-19 Identities = 102/423 (24%), Positives = 177/423 (41%), Gaps = 46/423 (10%) Query: 85 SRLHVRCSQRPPLSLWAGWVLECP----------LFKNFIIFLVFLNTIILMVEIELLES 134 +RL R S+ W W C +F +IFLVFLNT+ + E Sbjct: 491 ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE-----H 545 Query: 135 TNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEV 193 N W L + A +L +F E+LLK S ++ S +N FD V +L + Sbjct: 546 YNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604 Query: 194 VVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFY 253 +V + + + +LR R+LR K+ + + ++ L+ +++S+ LL+LL +F Sbjct: 605 LVETKIMSP-LGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFII 663 Query: 254 IFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQD---VWKVP 310 IF++ G+ +F F + P SL+TVF + T + W +++ D + P Sbjct: 664 IFSLLGMQLFGGKFNFDEMQTRRSTF-DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722 Query: 311 EVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTN------FQNIRKELNEEMARREVQLKA 364 + IYFI+ + G+ I ++ +A+ V N + +KE EE R+++ A Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782 Query: 365 DMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGAS--------------QQRESLDLSEVS 410 K+Q + + + S KIE S A Q E+ D S Sbjct: 783 SPEKKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYP 838 Query: 411 EVESNYGATEEDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDW 470 E+ EE+ LS+ + + + S+ + SS +RF R+ Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVN 898 Query: 471 ETL 473 +T+ Sbjct: 899 DTI 901 Score = 71.6 bits (174), Expect = 2e-12 Identities = 78/364 (21%), Positives = 152/364 (41%), Gaps = 63/364 (17%) Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163 ++E F+ I+ +F N + L + I E + LE + L+IF +E L Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNAT---NSNLERVEYLFLIIFTVEAFL 176 Query: 164 KWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVV---------LVGVTGQSVWLQLL 209 K ++ +F +A WN+ DF++ ++ L ++ +G G ++ L Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236 Query: 210 RICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------ 263 R RVLR L+L++ +Q+++ +++A+ + + +L+L I+A+ G+ +F Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296 Query: 264 ------------SEYTRSP--------RQ-----------DLEYH--VFFSDLPNSLVTV 290 +E SP RQ D H F + +++TV Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTV 356 Query: 291 FILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350 F T++ W +L W V R + IYF+ +++GS ++++ ++ F KE Sbjct: 357 FQCITMEGWTDVL--YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS---KE 411 Query: 351 LNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGASQQRESLDLSEVS 410 + AR + Q + K+Q+ + K + E+ G +++ S Sbjct: 412 REKAKARGDFQKLRE--KQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTS 469 Query: 411 EVES 414 E ES Sbjct: 470 ETES 473 Score = 71.6 bits (174), Expect = 2e-12 Identities = 60/300 (20%), Positives = 136/300 (45%), Gaps = 52/300 (17%) Query: 103 WVLECPLFKNFIIFLVFLNTIILMVE-----------IELLESTNTKLWPLKLTLEVAAW 151 +V+ F+ + L+ LNTI L ++ + +L T L+ +++ L++ A+ Sbjct: 1234 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF 1293 Query: 152 ------------FILLIFILEILLKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGV 199 F LI I I+ LS + ++ AWN FD ++ + S++ + V Sbjct: 1294 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNP 1353 Query: 200 TGQS-------------VWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLM 246 + + + R+ RV+R +KLL++ I+ ++ +++ +++ ++ + Sbjct: 1354 AEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1413 Query: 247 LLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHW----YAL 302 L+++ F+I+AV G+ VF + + ++ + F P +++ +F T + W A Sbjct: 1414 LIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLAC 1473 Query: 303 LQDVWKVPE------------VSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350 + PE F+ YFI + +L + + ++ VA+++ NF + ++ Sbjct: 1474 MPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD 1533 Score = 55.8 bits (133), Expect = 9e-08 Identities = 59/296 (19%), Positives = 133/296 (44%), Gaps = 65/296 (21%) Query: 109 LFKNFIIFLVFLNTIILMVE------------IELLESTNTKLWPLKLTLEV---AAWFI 153 +F N I+F + L++I L E + + T ++ +++ L++ A + Sbjct: 901 IFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVF 960 Query: 154 LLIFILEILLKWLS-----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQ 207 IF LEI+LK + + F ++ +N+ D +V +SL+ G+ ++ ++ Sbjct: 961 TSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLIS-----FGIQSSAINVVK 1015 Query: 208 LLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE-- 265 +LR+ RVLR L+ + + + ++ ++ + A++++ ++++ + ++FA GV +F Sbjct: 1016 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1075 Query: 266 YTRS----------------------------PRQDLEYHVFFSDLPNSLVTVFILFTLD 297 YT S PR F ++ +++ +F + T + Sbjct: 1076 YTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1135 Query: 298 HWYALL--------QDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ 345 W LL +D + R+ SI+FI+++++ + +I V ++ FQ Sbjct: 1136 GWPELLYRSIDSHTEDKGPIYNY-RVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1190 >gi|120433602 calcium channel, voltage-dependent, L type, alpha 1C subunit isoform 18 [Homo sapiens] Length = 2138 Score = 94.7 bits (234), Expect = 2e-19 Identities = 102/423 (24%), Positives = 177/423 (41%), Gaps = 46/423 (10%) Query: 85 SRLHVRCSQRPPLSLWAGWVLECP----------LFKNFIIFLVFLNTIILMVEIELLES 134 +RL R S+ W W C +F +IFLVFLNT+ + E Sbjct: 491 ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE-----H 545 Query: 135 TNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEV 193 N W L + A +L +F E+LLK S ++ S +N FD V +L + Sbjct: 546 YNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604 Query: 194 VVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFY 253 +V + + + +LR R+LR K+ + + ++ L+ +++S+ LL+LL +F Sbjct: 605 LVETKIMSP-LGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFII 663 Query: 254 IFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQD---VWKVP 310 IF++ G+ +F F + P SL+TVF + T + W +++ D + P Sbjct: 664 IFSLLGMQLFGGKFNFDEMQTRRSTF-DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722 Query: 311 EVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTN------FQNIRKELNEEMARREVQLKA 364 + IYFI+ + G+ I ++ +A+ V N + +KE EE R+++ A Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782 Query: 365 DMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGAS--------------QQRESLDLSEVS 410 K+Q + + + S KIE S A Q E+ D S Sbjct: 783 SPEKKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYP 838 Query: 411 EVESNYGATEEDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDW 470 E+ EE+ LS+ + + + S+ + SS +RF R+ Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVN 898 Query: 471 ETL 473 +T+ Sbjct: 899 DTI 901 Score = 71.6 bits (174), Expect = 2e-12 Identities = 78/364 (21%), Positives = 152/364 (41%), Gaps = 63/364 (17%) Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163 ++E F+ I+ +F N + L + I E + LE + L+IF +E L Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNAT---NSNLERVEYLFLIIFTVEAFL 176 Query: 164 KWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVV---------LVGVTGQSVWLQLL 209 K ++ +F +A WN+ DF++ ++ L ++ +G G ++ L Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236 Query: 210 RICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------ 263 R RVLR L+L++ +Q+++ +++A+ + + +L+L I+A+ G+ +F Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296 Query: 264 ------------SEYTRSP--------RQ-----------DLEYH--VFFSDLPNSLVTV 290 +E SP RQ D H F + +++TV Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTV 356 Query: 291 FILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350 F T++ W +L W V R + IYF+ +++GS ++++ ++ F KE Sbjct: 357 FQCITMEGWTDVL--YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS---KE 411 Query: 351 LNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGASQQRESLDLSEVS 410 + AR + Q + K+Q+ + K + E+ G +++ S Sbjct: 412 REKAKARGDFQKLRE--KQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTS 469 Query: 411 EVES 414 E ES Sbjct: 470 ETES 473 Score = 68.9 bits (167), Expect = 1e-11 Identities = 53/278 (19%), Positives = 128/278 (46%), Gaps = 36/278 (12%) Query: 103 WVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEIL 162 +V+ F+ + L+ LNTI L ++ + K+ + + +F +E++ Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQ------HYGQSCLFKIAMNILNMLFTGLFTVEMI 1267 Query: 163 LKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQS-------------VWLQL 208 LK ++ ++ AWN FD ++ + S++ + V + + + Sbjct: 1268 LKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITF 1327 Query: 209 LRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTR 268 R+ RV+R +KLL++ I+ ++ +++ +++ ++ +L+++ F+I+AV G+ VF + Sbjct: 1328 FRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL 1387 Query: 269 SPRQDLEYHVFFSDLPNSLVTVFILFTLDHW----YALLQDVWKVPE------------V 312 + ++ + F P +++ +F T + W A + PE Sbjct: 1388 NDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPC 1447 Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350 F+ YFI + +L + + ++ VA+++ NF + ++ Sbjct: 1448 GSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD 1485 Score = 51.2 bits (121), Expect = 2e-06 Identities = 57/283 (20%), Positives = 125/283 (44%), Gaps = 59/283 (20%) Query: 109 LFKNFIIFLVFLNTIILMVE--IELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWL 166 +F N I+F + L++I L E ++ N L+ + IF +EI LK Sbjct: 901 IFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTT-------IFTIEIALKMT 953 Query: 167 S-----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQLLRICRVLRSLKL 220 + + F ++ +N+ D +V +SL+ G+ ++ +++LR+ RVLR L+ Sbjct: 954 AYGAFLHKGSFCRNYFNILDLLVVSVSLIS-----FGIQSSAINVVKILRVLRVLRPLRA 1008 Query: 221 LAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE--YTRS--------- 269 + + + ++ ++ + A++++ ++++ + ++FA GV +F YT S Sbjct: 1009 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1068 Query: 270 -------------------PRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALL------- 303 PR F ++ +++ +F + T + W LL Sbjct: 1069 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1128 Query: 304 -QDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ 345 +D + R+ SI+FI+++++ + +I V ++ FQ Sbjct: 1129 TEDKGPIYNY-RVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1170 >gi|193788548 calcium channel, voltage-dependent, L type, alpha 1C subunit isoform 20 [Homo sapiens] Length = 2127 Score = 94.7 bits (234), Expect = 2e-19 Identities = 102/423 (24%), Positives = 177/423 (41%), Gaps = 46/423 (10%) Query: 85 SRLHVRCSQRPPLSLWAGWVLECP----------LFKNFIIFLVFLNTIILMVEIELLES 134 +RL R S+ W W C +F +IFLVFLNT+ + E Sbjct: 491 ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE-----H 545 Query: 135 TNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEV 193 N W L + A +L +F E+LLK S ++ S +N FD V +L + Sbjct: 546 YNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 604 Query: 194 VVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFY 253 +V + + + +LR R+LR K+ + + ++ L+ +++S+ LL+LL +F Sbjct: 605 LVETKIMSP-LGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFII 663 Query: 254 IFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQD---VWKVP 310 IF++ G+ +F F + P SL+TVF + T + W +++ D + P Sbjct: 664 IFSLLGMQLFGGKFNFDEMQTRRSTF-DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 722 Query: 311 EVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTN------FQNIRKELNEEMARREVQLKA 364 + IYFI+ + G+ I ++ +A+ V N + +KE EE R+++ A Sbjct: 723 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 782 Query: 365 DMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGAS--------------QQRESLDLSEVS 410 K+Q + + + S KIE S A Q E+ D S Sbjct: 783 SPEKKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYP 838 Query: 411 EVESNYGATEEDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDW 470 E+ EE+ LS+ + + + S+ + SS +RF R+ Sbjct: 839 NPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVN 898 Query: 471 ETL 473 +T+ Sbjct: 899 DTI 901 Score = 73.6 bits (179), Expect = 4e-13 Identities = 53/267 (19%), Positives = 129/267 (48%), Gaps = 25/267 (9%) Query: 103 WVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEIL 162 +V+ F+ + L+ LNTI L ++ + K+ + + +F +E++ Sbjct: 1214 YVVNSTYFEYLMFVLILLNTICLAMQ------HYGQSCLFKIAMNILNMLFTGLFTVEMI 1267 Query: 163 LKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQS--VWLQLLRICRVLRSLK 219 LK ++ ++ AWN FD ++ + S++ + V ++ + + R+ RV+R +K Sbjct: 1268 LKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVK 1327 Query: 220 LLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVF 279 LL++ I+ ++ +++ +++ ++ +L+++ F+I+AV G+ VF + + ++ + Sbjct: 1328 LLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNN 1387 Query: 280 FSDLPNSLVTVFILFTLDHW----YALLQDVWKVPE------------VSRIFSSIYFIL 323 F P +++ +F T + W A + PE F+ YFI Sbjct: 1388 FQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFIS 1447 Query: 324 WLLLGSIIFRSIIVAMMVTNFQNIRKE 350 + +L + + ++ VA+++ NF + ++ Sbjct: 1448 FYMLCAFLIINLFVAVIMDNFDYLTRD 1474 Score = 71.6 bits (174), Expect = 2e-12 Identities = 78/364 (21%), Positives = 152/364 (41%), Gaps = 63/364 (17%) Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163 ++E F+ I+ +F N + L + I E + LE + L+IF +E L Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNAT---NSNLERVEYLFLIIFTVEAFL 176 Query: 164 KWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVV---------LVGVTGQSVWLQLL 209 K ++ +F +A WN+ DF++ ++ L ++ +G G ++ L Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236 Query: 210 RICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------ 263 R RVLR L+L++ +Q+++ +++A+ + + +L+L I+A+ G+ +F Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296 Query: 264 ------------SEYTRSP--------RQ-----------DLEYH--VFFSDLPNSLVTV 290 +E SP RQ D H F + +++TV Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTV 356 Query: 291 FILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350 F T++ W +L W V R + IYF+ +++GS ++++ ++ F KE Sbjct: 357 FQCITMEGWTDVL--YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS---KE 411 Query: 351 LNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGASQQRESLDLSEVS 410 + AR + Q + K+Q+ + K + E+ G +++ S Sbjct: 412 REKAKARGDFQKLRE--KQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTS 469 Query: 411 EVES 414 E ES Sbjct: 470 ETES 473 Score = 55.1 bits (131), Expect = 2e-07 Identities = 59/281 (20%), Positives = 129/281 (45%), Gaps = 55/281 (19%) Query: 109 LFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLS- 167 +F N I+F + L++I L E + ++ T+ + L A + IF LEI+LK + Sbjct: 901 IFTNLILFFILLSSISLAAE-DPVQHTSFR----NHILGNADYVFTSIFTLEIILKMTAY 955 Query: 168 ----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQLLRICRVLRSLKLLA 222 + F ++ +N+ D +V +SL+ G+ ++ +++LR+ RVLR L+ + Sbjct: 956 GAFLHKGSFCRNYFNILDLLVVSVSLIS-----FGIQSSAINVVKILRVLRVLRPLRAIN 1010 Query: 223 QFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE--YTRS----------- 269 + + ++ ++ + A++++ ++++ + ++FA GV +F YT S Sbjct: 1011 RAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECK 1070 Query: 270 -----------------PRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALL--------Q 304 PR F ++ +++ +F + T + W LL + Sbjct: 1071 GNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTE 1130 Query: 305 DVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ 345 D + R+ SI+FI+++++ + +I V ++ FQ Sbjct: 1131 DKGPIYNY-RVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1170 >gi|193788544 calcium channel, voltage-dependent, L type, alpha 1C subunit isoform 19 [Homo sapiens] Length = 2135 Score = 94.7 bits (234), Expect = 2e-19 Identities = 102/423 (24%), Positives = 177/423 (41%), Gaps = 46/423 (10%) Query: 85 SRLHVRCSQRPPLSLWAGWVLECP----------LFKNFIIFLVFLNTIILMVEIELLES 134 +RL R S+ W W C +F +IFLVFLNT+ + E Sbjct: 488 ARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE-----H 542 Query: 135 TNTKLWPLKLTLEVAAWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEV 193 N W L + A +L +F E+LLK S ++ S +N FD V +L + Sbjct: 543 YNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI 601 Query: 194 VVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFY 253 +V + + + +LR R+LR K+ + + ++ L+ +++S+ LL+LL +F Sbjct: 602 LVETKIMSP-LGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFII 660 Query: 254 IFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQD---VWKVP 310 IF++ G+ +F F + P SL+TVF + T + W +++ D + P Sbjct: 661 IFSLLGMQLFGGKFNFDEMQTRRSTF-DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 719 Query: 311 EVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTN------FQNIRKELNEEMARREVQLKA 364 + IYFI+ + G+ I ++ +A+ V N + +KE EE R+++ A Sbjct: 720 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTA 779 Query: 365 DMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGAS--------------QQRESLDLSEVS 410 K+Q + + + S KIE S A Q E+ D S Sbjct: 780 SPEKKQELVEKPAVGE----SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYP 835 Query: 411 EVESNYGATEEDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDW 470 E+ EE+ LS+ + + + S+ + SS +RF R+ Sbjct: 836 NPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVN 895 Query: 471 ETL 473 +T+ Sbjct: 896 DTI 898 Score = 72.8 bits (177), Expect = 7e-13 Identities = 78/361 (21%), Positives = 152/361 (42%), Gaps = 60/361 (16%) Query: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163 ++E F+ I+ +F N + L + I E + LE + L+IF +E L Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNAT---NSNLERVEYLFLIIFTVEAFL 176 Query: 164 KWLSNFSVFWKSA-----WNVFDFVVTMLSLLPEVVV---------LVGVTGQSVWLQLL 209 K ++ +F +A WN+ DF++ ++ L ++ +G G ++ L Sbjct: 177 KVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKAL 236 Query: 210 RICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF------ 263 R RVLR L+L++ +Q+++ +++A+ + + +L+L I+A+ G+ +F Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296 Query: 264 ---------SEYTRSP--------RQ-----------DLEYH--VFFSDLPNSLVTVFIL 293 +E SP RQ D H F + +++TVF Sbjct: 297 TCYNQEGIAAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQC 356 Query: 294 FTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNE 353 T++ W +L W V R + IYF+ +++GS ++++ ++ F KE + Sbjct: 357 ITMEGWTDVL--YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS---KEREK 411 Query: 354 EMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGASQQRESLDLSEVSEVE 413 AR + Q + K+Q+ + K + E+ G +++ SE E Sbjct: 412 AKARGDFQKLRE--KQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETE 469 Query: 414 S 414 S Sbjct: 470 S 470 Score = 72.0 bits (175), Expect = 1e-12 Identities = 53/278 (19%), Positives = 129/278 (46%), Gaps = 36/278 (12%) Query: 103 WVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEIL 162 +V+ F+ + L+ LNTI L ++ + K+ + + +F +E++ Sbjct: 1211 YVVNSTYFEYLMFVLILLNTICLAMQ------HYGQSCLFKIAMNILNMLFTGLFTVEMI 1264 Query: 163 LKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEVVV-------------LVGVTGQSVWLQL 208 LK ++ ++ WNVFDF++ + S++ ++ + + + Sbjct: 1265 LKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITF 1324 Query: 209 LRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTR 268 R+ RV+R +KLL++ I+ ++ +++ +++ ++ +L+++ F+I+AV G+ VF + Sbjct: 1325 FRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL 1384 Query: 269 SPRQDLEYHVFFSDLPNSLVTVFILFTLDHW----YALLQDVWKVPE------------V 312 + ++ + F P +++ +F T + W A + PE Sbjct: 1385 NDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPC 1444 Query: 313 SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKE 350 F+ YFI + +L + + ++ VA+++ NF + ++ Sbjct: 1445 GSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD 1482 Score = 51.2 bits (121), Expect = 2e-06 Identities = 57/283 (20%), Positives = 125/283 (44%), Gaps = 59/283 (20%) Query: 109 LFKNFIIFLVFLNTIILMVE--IELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWL 166 +F N I+F + L++I L E ++ N L+ + IF +EI LK Sbjct: 898 IFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTT-------IFTIEIALKMT 950 Query: 167 S-----NFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV-WLQLLRICRVLRSLKL 220 + + F ++ +N+ D +V +SL+ G+ ++ +++LR+ RVLR L+ Sbjct: 951 AYGAFLHKGSFCRNYFNILDLLVVSVSLIS-----FGIQSSAINVVKILRVLRVLRPLRA 1005 Query: 221 LAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSE--YTRS--------- 269 + + + ++ ++ + A++++ ++++ + ++FA GV +F YT S Sbjct: 1006 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE 1065 Query: 270 -------------------PRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALL------- 303 PR F ++ +++ +F + T + W LL Sbjct: 1066 CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSH 1125 Query: 304 -QDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQ 345 +D + R+ SI+FI+++++ + +I V ++ FQ Sbjct: 1126 TEDKGPIYNY-RVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1167 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.325 0.136 0.396 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,949,181 Number of Sequences: 37866 Number of extensions: 672017 Number of successful extensions: 5942 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 111 Number of HSP's successfully gapped in prelim test: 156 Number of HSP's that attempted gapping in prelim test: 4409 Number of HSP's gapped (non-prelim): 882 length of query: 530 length of database: 18,247,518 effective HSP length: 107 effective length of query: 423 effective length of database: 14,195,856 effective search space: 6004847088 effective search space used: 6004847088 T: 11 A: 40 X1: 15 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.6 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.