BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|254039600 F-box and leucine-rich repeat protein 17 [Homo sapiens] (303 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|254039600 F-box and leucine-rich repeat protein 17 [Homo sapi... 614 e-176 gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens] 111 9e-25 gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens] 95 9e-20 gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens] 93 3e-19 gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens] 90 2e-18 gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1 ... 82 6e-16 gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2 ... 76 4e-14 gi|164663798 antagonist of mitotic exit network 1 homolog [Homo ... 74 2e-13 gi|190194416 F-box and leucine-rich repeat protein 15 [Homo sapi... 66 3e-11 gi|16306588 F-box and leucine-rich repeat protein 4 [Homo sapiens] 63 3e-10 gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens] 59 4e-09 gi|51873034 F-box and leucine-rich repeat protein 9 [Homo sapiens] 48 9e-06 gi|16306591 F-box and leucine-rich repeat protein 9 [Homo sapiens] 48 9e-06 gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens] 41 0.001 gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [... 41 0.001 gi|5453880 acidic (leucine-rich) nuclear phosphoprotein 32 famil... 40 0.003 gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [... 40 0.003 gi|13569879 acidic (leucine-rich) nuclear phosphoprotein 32 fami... 37 0.022 gi|210147571 acidic (leucine-rich) nuclear phosphoprotein 32 fam... 37 0.022 gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 36 0.048 gi|6912604 acidic nuclear phosphoprotein 32C [Homo sapiens] 35 0.11 gi|8923179 F-box and leucine-rich repeat protein 12 [Homo sapiens] 34 0.18 gi|16306584 F-box and leucine-rich repeat protein 3 [Homo sapiens] 33 0.24 gi|116268109 nucleotide-binding oligomerization domains 27 [Homo... 33 0.41 gi|55742693 zyg-11 homolog B [Homo sapiens] 32 0.53 gi|16306574 F-box and leucine-rich repeat protein 5 isoform 2 [H... 32 0.91 gi|16306572 F-box and leucine-rich repeat protein 5 isoform 1 [H... 32 0.91 gi|16306576 F-box and leucine-rich repeat protein 6 isoform 1 [H... 32 0.91 gi|239754160 PREDICTED: similar to hCG1980490 [Homo sapiens] 31 1.5 gi|239748674 PREDICTED: similar to hCG1980490 [Homo sapiens] 31 1.5 >gi|254039600 F-box and leucine-rich repeat protein 17 [Homo sapiens] Length = 303 Score = 614 bits (1584), Expect = e-176 Identities = 303/303 (100%), Positives = 303/303 (100%) Query: 1 MSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQ 60 MSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQ Sbjct: 1 MSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQ 60 Query: 61 LGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPEL 120 LGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPEL Sbjct: 61 LGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPEL 120 Query: 121 QYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWI 180 QYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWI Sbjct: 121 QYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWI 180 Query: 181 INDRCVEVIAKEGQNLKELYLVSCKITDYALIAIGRYSMTIETVDVGWCKEITDQGATLI 240 INDRCVEVIAKEGQNLKELYLVSCKITDYALIAIGRYSMTIETVDVGWCKEITDQGATLI Sbjct: 181 INDRCVEVIAKEGQNLKELYLVSCKITDYALIAIGRYSMTIETVDVGWCKEITDQGATLI 240 Query: 241 AQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHITFSTVLQDCKRTLERAYQMGWTPNMSA 300 AQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHITFSTVLQDCKRTLERAYQMGWTPNMSA Sbjct: 241 AQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHITFSTVLQDCKRTLERAYQMGWTPNMSA 300 Query: 301 ASS 303 ASS Sbjct: 301 ASS 303 >gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens] Length = 418 Score = 111 bits (277), Expect = 9e-25 Identities = 74/277 (26%), Positives = 142/277 (51%), Gaps = 9/277 (3%) Query: 1 MSDNGVCVLAFKCPGLLR-YTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLK 59 ++DNG+ + G LR CKQ++D+S+ +A + L+ + +G +T+ GL Sbjct: 103 LTDNGLGHAFVQEIGSLRALNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLL 162 Query: 60 QLGSKCRELKDIHFGQCYKISDEGMIVIA-------KGCLKLQRIYMQENKLVTDQSVKA 112 + + LK ++ C +SD G+ +A +GCL L+++ +Q+ + +TD S+K Sbjct: 163 LIAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKH 222 Query: 113 FAEHCPELQYVGFMGCS-VTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLS 171 + L+ + C ++ G++HL+ + +L SL+LR + + +M + LS Sbjct: 223 ISRGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMGSLRLS 282 Query: 172 SLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITDYALIAIGRYSMTIETVDVGWCKE 231 L++ + D+ + IA+ LK L L SC I+D + + R + T+++G C Sbjct: 283 GLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSCHISDDGINRMVRQMHGLRTLNIGQCVR 342 Query: 232 ITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQLVQ 268 ITD+G LIA+ L + L C ++ + +E++ Q Sbjct: 343 ITDKGLELIAEHLSQLTGIDLYGCTRITKRGLERITQ 379 >gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens] Length = 491 Score = 94.7 bits (234), Expect = 9e-20 Identities = 71/277 (25%), Positives = 125/277 (45%), Gaps = 15/277 (5%) Query: 1 MSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLT------ 54 ++D G+ +A CP L R C +S+ ++ V S CP L+ + V K+T Sbjct: 199 LTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTR 258 Query: 55 --DEGLKQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKA 112 L L K ++ + C+ + DEG+ IA C +L +Y++ +TD+ ++ Sbjct: 259 EASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRY 318 Query: 113 FAEHCPELQYVGFMGCS-VTSKGVIHLTKLRN-LSSLDLRHITELDNETVMEIVKRCKNL 170 +C ++ + C V+ G+ + KL + L L + H + + + + K C L Sbjct: 319 LVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKL 378 Query: 171 SSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCK-ITDYALIAIGRYSMTIETVDVGWC 229 LN I D VE +AK LK L + C ++D L + ++ + + C Sbjct: 379 RYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSC 438 Query: 230 KEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQL 266 + IT QG ++A + L+ L + C EV+VE L Sbjct: 439 ESITGQGLQIVAANCFDLQTLNVQDC----EVSVEAL 471 Score = 82.4 bits (202), Expect = 4e-16 Identities = 55/196 (28%), Positives = 100/196 (51%), Gaps = 2/196 (1%) Query: 24 CKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEG 83 C L D + +A+HC L +++ +LTDEGL+ L C +K++ C +SD G Sbjct: 282 CFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFG 341 Query: 84 MIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGC-SVTSKGVIHLTK-L 141 + IAK +L+ + + VTD ++ A++C +L+Y+ GC +T GV +L K Sbjct: 342 LREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNC 401 Query: 142 RNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYL 201 L SLD+ + + + + C NL L+L I + ++++A +L+ L + Sbjct: 402 TKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNV 461 Query: 202 VSCKITDYALIAIGRY 217 C+++ AL + R+ Sbjct: 462 QDCEVSVEALRFVKRH 477 Score = 80.9 bits (198), Expect = 1e-15 Identities = 59/239 (24%), Positives = 109/239 (45%), Gaps = 11/239 (4%) Query: 39 CPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIY 98 C +L+ V V +LTD GL + C EL+ + CY IS+E + + C L+ + Sbjct: 185 CLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLD 244 Query: 99 MQENKLVT------DQSVKAFAEHCPE--LQYVGFMGCSVTSKGVIH--LTKLRNLSSLD 148 + VT + S+K H + ++Y+ C V +H L+ L Sbjct: 245 VSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLY 304 Query: 149 LRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSC-KIT 207 LR L +E + +V C ++ L++ ++D + IAK L+ L + C ++T Sbjct: 305 LRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVT 364 Query: 208 DYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQL 266 D + + +Y + ++ C+ ITD G +A++ L+ L + +C V++ +E L Sbjct: 365 DVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECL 423 Score = 76.6 bits (187), Expect = 2e-14 Identities = 51/215 (23%), Positives = 101/215 (46%), Gaps = 11/215 (5%) Query: 65 CRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVG 124 C L+ + C +++D G+ IA+ C +L+R+ + +++++V CP L+++ Sbjct: 185 CLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLD 244 Query: 125 FMGCS------VTSKGVIHLTKLR----NLSSLDLRHITELDNETVMEIVKRCKNLSSLN 174 GCS +T + I L+ L ++ LD+ L++E + I C L+ L Sbjct: 245 VSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLY 304 Query: 175 LCLNWIINDRCVEVIAKEGQNLKELYLVSCK-ITDYALIAIGRYSMTIETVDVGWCKEIT 233 L + D + + ++KEL + C+ ++D+ L I + + + + C +T Sbjct: 305 LRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVT 364 Query: 234 DQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQLVQ 268 D G +A+ LRYL C+ + + VE L + Sbjct: 365 DVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAK 399 Score = 36.2 bits (82), Expect = 0.037 Identities = 18/55 (32%), Positives = 29/55 (52%) Query: 219 MTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHI 273 + +ETV V C+ +TD+G IAQ LR L + C ++ V +V P++ Sbjct: 186 LMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNL 240 >gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens] Length = 423 Score = 93.2 bits (230), Expect = 3e-19 Identities = 68/264 (25%), Positives = 116/264 (43%), Gaps = 26/264 (9%) Query: 12 KCPGLLRYTAYR-CKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKD 70 +C G LR + R C + D+S+ A +C ++ +++ K+TD L C +LK Sbjct: 75 RCGGFLRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFCSKLKH 134 Query: 71 IHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSV 130 + C I++ + I++GC L+ + + +T ++A C Sbjct: 135 LDLTSCVSITNSSLKGISEGCRNLEYLNLSWCDQITKDGIEALVRGC------------- 181 Query: 131 TSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIA 190 R L +L LR T+L++E + I C L SLNL I D V I Sbjct: 182 -----------RGLKALLLRGCTQLEDEALKHIQNYCHELVSLNLQSCSRITDEGVVQIC 230 Query: 191 KEGQNLKELYLVSC-KITDYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRY 249 + L+ L L C +TD +L A+G ++ ++ C +TD G TL+A++ L Sbjct: 231 RGCHRLQALCLSGCSNLTDASLTALGLNCPRLQILEAARCSHLTDAGFTLLARNCHELEK 290 Query: 250 LGLMRCDKVNEVTVEQLVQQYPHI 273 + L C + + T+ QL P + Sbjct: 291 MDLEECILITDSTLIQLSIHCPKL 314 Score = 90.9 bits (224), Expect = 1e-18 Identities = 60/272 (22%), Positives = 130/272 (47%), Gaps = 6/272 (2%) Query: 1 MSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQ 60 + D+ + A C + C +++D++ +++ C L+ + + + +T+ LK Sbjct: 91 VGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFCSKLKHLDLTSCVSITNSSLKG 150 Query: 61 LGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPEL 120 + CR L+ ++ C +I+ +G+ + +GC L+ + ++ + D+++K +C EL Sbjct: 151 ISEGCRNLEYLNLSWCDQITKDGIEALVRGCRGLKALLLRGCTQLEDEALKHIQNYCHEL 210 Query: 121 QYVGFMGCS-VTSKGVIHLTK-LRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLN 178 + CS +T +GV+ + + L +L L + L + ++ + C L L Sbjct: 211 VSLNLQSCSRITDEGVVQICRGCHRLQALCLSGCSNLTDASLTALGLNCPRLQILEAARC 270 Query: 179 WIINDRCVEVIAKEGQNLKELYLVSC-KITDYALIAIGRYSMTIETVDVGWCKEITDQGA 237 + D ++A+ L+++ L C ITD LI + + ++ + + C+ ITD G Sbjct: 271 SHLTDAGFTLLARNCHELEKMDLEECILITDSTLIQLSIHCPKLQALSLSHCELITDDGI 330 Query: 238 TLIAQSS---KSLRYLGLMRCDKVNEVTVEQL 266 ++ S+ + LR L L C + +V +E L Sbjct: 331 LHLSNSTCGHERLRVLELDNCLLITDVALEHL 362 Score = 83.6 bits (205), Expect = 2e-16 Identities = 44/169 (26%), Positives = 85/169 (50%), Gaps = 8/169 (4%) Query: 13 CPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIH 72 C L+ C +++D ++ + C LQ + + LTD L LG C L+ + Sbjct: 207 CHELVSLNLQSCSRITDEGVVQICRGCHRLQALCLSGCSNLTDASLTALGLNCPRLQILE 266 Query: 73 FGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCS-VT 131 +C ++D G ++A+ C +L+++ ++E L+TD ++ + HCP+LQ + C +T Sbjct: 267 AARCSHLTDAGFTLLARNCHELEKMDLEECILITDSTLIQLSIHCPKLQALSLSHCELIT 326 Query: 132 SKGVIHLTKLRNLSSLDLRHITELDN-----ETVMEIVKRCKNLSSLNL 175 G++HL+ + + + ELDN + +E ++ C+ L L L Sbjct: 327 DDGILHLS--NSTCGHERLRVLELDNCLLITDVALEHLENCRGLERLEL 373 Score = 82.0 bits (201), Expect = 6e-16 Identities = 60/219 (27%), Positives = 109/219 (49%), Gaps = 7/219 (3%) Query: 24 CKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEG 83 C Q++ I A+ C L+ + + +L DE LK + + C EL ++ C +I+DEG Sbjct: 166 CDQITKDGIEALVRGCRGLKALLLRGCTQLEDEALKHIQNYCHELVSLNLQSCSRITDEG 225 Query: 84 MIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCS-VTSKGVIHLTK-L 141 ++ I +GC +LQ + + +TD S+ A +CP LQ + CS +T G L + Sbjct: 226 VVQICRGCHRLQALCLSGCSNLTDASLTALGLNCPRLQILEAARCSHLTDAGFTLLARNC 285 Query: 142 RNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKE---GQNLKE 198 L +DL + + T++++ C L +L+L +I D + ++ + L+ Sbjct: 286 HELEKMDLEECILITDSTLIQLSIHCPKLQALSLSHCELITDDGILHLSNSTCGHERLRV 345 Query: 199 LYLVSC-KITDYALIAIGRYSMTIETVDVGWCKEITDQG 236 L L +C ITD AL + +E +++ C+++T G Sbjct: 346 LELDNCLLITDVALEHL-ENCRGLERLELYDCQQVTRAG 383 Score = 65.9 bits (159), Expect = 4e-11 Identities = 42/153 (27%), Positives = 68/153 (44%), Gaps = 4/153 (2%) Query: 1 MSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQ 60 ++D GV + C L C L+D S+ A+ +CP LQ + LTD G Sbjct: 221 ITDEGVVQICRGCHRLQALCLSGCSNLTDASLTALGLNCPRLQILEAARCSHLTDAGFTL 280 Query: 61 LGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHC--- 117 L C EL+ + +C I+D +I ++ C KLQ + + +L+TD + + Sbjct: 281 LARNCHELEKMDLEECILITDSTLIQLSIHCPKLQALSLSHCELITDDGILHLSNSTCGH 340 Query: 118 PELQYVGFMGC-SVTSKGVIHLTKLRNLSSLDL 149 L+ + C +T + HL R L L+L Sbjct: 341 ERLRVLELDNCLLITDVALEHLENCRGLERLEL 373 >gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens] Length = 436 Score = 90.1 bits (222), Expect = 2e-18 Identities = 61/229 (26%), Positives = 111/229 (48%), Gaps = 5/229 (2%) Query: 13 CPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIH 72 CP L + C Q++ I A+ C L+ + + +L DE LK +G+ C EL ++ Sbjct: 168 CPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLN 227 Query: 73 FGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCS-VT 131 C +I+DEG+I I +GC KLQ + +TD + A ++CP L+ + CS +T Sbjct: 228 LQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLT 287 Query: 132 SKGVIHLTK-LRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVI- 189 G L + L +DL ++ + T++++ C L L+L +I D + + Sbjct: 288 DVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLG 347 Query: 190 --AKEGQNLKELYLVSCKITDYALIAIGRYSMTIETVDVGWCKEITDQG 236 A L+ + L +C + A + + ++E +++ C++IT G Sbjct: 348 NGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAG 396 Score = 86.3 bits (212), Expect = 3e-17 Identities = 61/290 (21%), Positives = 132/290 (45%), Gaps = 8/290 (2%) Query: 1 MSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQ 60 + DN + A C + C + +D + +++ C L+ + + + +T+ LK Sbjct: 104 VGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKA 163 Query: 61 LGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPEL 120 L C L+ ++ C +++ +G+ + +GC L+ ++++ + D+++K HCPEL Sbjct: 164 LSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPEL 223 Query: 121 QYVGFMGC-SVTSKGVIHLTK-LRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLN 178 + C +T +G+I + + L SL + + + + + + C L L + Sbjct: 224 VTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARC 283 Query: 179 WIINDRCVEVIAKEGQNLKELYLVSC-KITDYALIAIGRYSMTIETVDVGWCKEITDQGA 237 + D +A+ L+++ L C +ITD LI + + ++ + + C+ ITD G Sbjct: 284 SQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGI 343 Query: 238 TLI---AQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHITFSTVLQDCKR 284 + A + L + L C + + ++E L + H L DC++ Sbjct: 344 RHLGNGACAHDQLEVIELDNCPLITDASLEHL--KSCHSLERIELYDCQQ 391 Score = 85.5 bits (210), Expect = 5e-17 Identities = 62/264 (23%), Positives = 114/264 (43%), Gaps = 26/264 (9%) Query: 12 KCPGLLRYTAYR-CKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKD 70 +C G LR + R C + D ++ A +C ++ +++ K TD L C +L+ Sbjct: 88 RCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRH 147 Query: 71 IHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSV 130 + C I++ + +++GC L+++ + VT ++A C L+ + GC Sbjct: 148 LDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGC-- 205 Query: 131 TSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIA 190 T+L++E + I C L +LNL I D + I Sbjct: 206 ----------------------TQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITIC 243 Query: 191 KEGQNLKELYLVSC-KITDYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRY 249 + L+ L C ITD L A+G+ + ++V C ++TD G T +A++ L Sbjct: 244 RGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEK 303 Query: 250 LGLMRCDKVNEVTVEQLVQQYPHI 273 + L C ++ + T+ QL P + Sbjct: 304 MDLEECVQITDSTLIQLSIHCPRL 327 Score = 62.0 bits (149), Expect = 6e-10 Identities = 34/124 (27%), Positives = 66/124 (53%), Gaps = 4/124 (3%) Query: 1 MSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQ 60 ++D G LA C L + C Q++D+++I ++ HCP LQ + + + + +TD+G++ Sbjct: 286 LTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRH 345 Query: 61 LGSKC---RELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHC 117 LG+ +L+ I C I+D + + K C L+RI + + + +T +K H Sbjct: 346 LGNGACAHDQLEVIELDNCPLITDASLEHL-KSCHSLERIELYDCQQITRAGIKRLRTHL 404 Query: 118 PELQ 121 P ++ Sbjct: 405 PNIK 408 >gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1 [Homo sapiens] Length = 735 Score = 82.0 bits (201), Expect = 6e-16 Identities = 80/316 (25%), Positives = 134/316 (42%), Gaps = 57/316 (18%) Query: 13 CPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIH 72 C L+ C Q+S +A+ C + + + + LTD +K L KC + + Sbjct: 323 CHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLV 382 Query: 73 FGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCS-VT 131 F ISD A KL++I + NK VTD S K ++ P L ++ C +T Sbjct: 383 FTGAPHISD--CTFRALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGIT 440 Query: 132 SKGVIHLTKLRNLS----------------------------SLDLRHITELDNETVMEI 163 + L+ L+ L+ L+L + L + +VM++ Sbjct: 441 DSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKL 500 Query: 164 VKRCKNLSSLNL--C-------LNWIIN-------DRCVEVIAKEGQN-------LKELY 200 +RC NL+ L+L C + +I+N D I+ EG N LKEL Sbjct: 501 SERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLSRHKKLKELS 560 Query: 201 LVSC-KITDYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVN 259 + C +ITD + A + S+ +E +DV +C +++D +A +L L + C K+ Sbjct: 561 VSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKALAIYCINLTSLSIAGCPKIT 620 Query: 260 EVTVEQLVQQ--YPHI 273 + +E L + Y HI Sbjct: 621 DSAMEMLSAKCHYLHI 636 Score = 77.4 bits (189), Expect = 1e-14 Identities = 64/283 (22%), Positives = 126/283 (44%), Gaps = 36/283 (12%) Query: 25 KQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEGM 84 K+++D S + + P L +++ + +TD L+ L S ++L ++ C +I D G+ Sbjct: 411 KRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSL-SPLKQLTVLNLANCVRIGDMGL 469 Query: 85 IVIAKG--CLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCS-VTSKGVIHLTKL 141 G ++++ + + ++D SV +E CP L Y+ C +T++G+ ++ + Sbjct: 470 KQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNI 529 Query: 142 RNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQ------- 194 +L S+DL T++ NE + ++ R K L L++ + I D ++ K Sbjct: 530 FSLVSIDLSG-TDISNEG-LNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDV 587 Query: 195 -------------------NLKELYLVSC-KITDYALIAIGRYSMTIETVDVGWCKEITD 234 NL L + C KITD A+ + + +D+ C +TD Sbjct: 588 SYCSQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTD 647 Query: 235 QGATLIAQSSKSLRYLGLMRCDKVNEVTVEQL---VQQYPHIT 274 Q + K LR L + C +++ +++ VQQ + T Sbjct: 648 QILEDLQIGCKQLRILKMQYCTNISKKAAQRMSSKVQQQEYNT 690 Score = 75.9 bits (185), Expect = 4e-14 Identities = 72/281 (25%), Positives = 122/281 (43%), Gaps = 44/281 (15%) Query: 13 CPGLLRYTAYRCKQLSDTSII-----AVASHCPLLQKVHVGNQDKLTDEGLK--QLGSKC 65 CPG+L C LS+T+I + H LQ + + + TD+GL+ LG+ C Sbjct: 270 CPGVL------CLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGC 323 Query: 66 RELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGF 125 +L + C +IS +G IA C + + + + +TD VKA E C + + F Sbjct: 324 HKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVF 383 Query: 126 MGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRC 185 G S R LS+ LR I N+ V D Sbjct: 384 TGAPHISD-----CTFRALSACKLRKIRFEGNKRV---------------------TDAS 417 Query: 186 VEVIAKEGQNLKELYLVSCK-ITDYALIAIGRYSMTIETVDVGWCKEITDQGAT--LIAQ 242 + I K NL +Y+ CK ITD +L ++ + +++ C I D G L Sbjct: 418 FKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQ-LTVLNLANCVRIGDMGLKQFLDGP 476 Query: 243 SSKSLRYLGLMRCDKVNEVTVEQLVQQYPHITFSTVLQDCK 283 +S +R L L C ++++ +V +L ++ P++ + + L++C+ Sbjct: 477 ASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLS-LRNCE 516 Score = 53.5 bits (127), Expect = 2e-07 Identities = 40/155 (25%), Positives = 73/155 (47%), Gaps = 4/155 (2%) Query: 123 VGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIIN 182 + F GC + K ++ RNL L++ +E++ I + C + LNL N I Sbjct: 226 LNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLS-NTTIT 284 Query: 183 DRCVEVIAKEGQNLKELYLVSC-KITDYAL--IAIGRYSMTIETVDVGWCKEITDQGATL 239 +R + ++ + NL+ L L C + TD L + +G + +D+ C +I+ QG Sbjct: 285 NRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRY 344 Query: 240 IAQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHIT 274 IA S + +L + + + V+ LV++ IT Sbjct: 345 IANSCTGIMHLTINDMPTLTDNCVKALVEKCSRIT 379 Score = 48.1 bits (113), Expect = 9e-06 Identities = 25/99 (25%), Positives = 50/99 (50%) Query: 24 CKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEG 83 C QLSD I A+A +C L + + K+TD ++ L +KC L + C ++D+ Sbjct: 590 CSQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQI 649 Query: 84 MIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQY 122 + + GC +L+ + MQ ++ ++ + + + +Y Sbjct: 650 LEDLQIGCKQLRILKMQYCTNISKKAAQRMSSKVQQQEY 688 Score = 45.1 bits (105), Expect = 8e-05 Identities = 33/133 (24%), Positives = 62/133 (46%), Gaps = 1/133 (0%) Query: 1 MSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQ 60 +S+ G+ VL+ + L + C +++D I A +L+ + V +L+D +K Sbjct: 542 ISNEGLNVLS-RHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKA 600 Query: 61 LGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPEL 120 L C L + C KI+D M +++ C L + + L+TDQ ++ C +L Sbjct: 601 LAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQL 660 Query: 121 QYVGFMGCSVTSK 133 + + C+ SK Sbjct: 661 RILKMQYCTNISK 673 Score = 40.0 bits (92), Expect = 0.003 Identities = 33/188 (17%), Positives = 76/188 (40%), Gaps = 25/188 (13%) Query: 1 MSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSI-----------------------IAVAS 37 +SD V L+ +CP L + C+ L+ I + V S Sbjct: 492 LSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLS 551 Query: 38 HCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRI 97 L+++ V ++TD+G++ L+ + C ++SD + +A C+ L + Sbjct: 552 RHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKALAIYCINLTSL 611 Query: 98 YMQENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHLTKL--RNLSSLDLRHITEL 155 + +TD +++ + C L + GC + + ++ ++ + L L +++ T + Sbjct: 612 SIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNI 671 Query: 156 DNETVMEI 163 + + Sbjct: 672 SKKAAQRM 679 >gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2 [Homo sapiens] Length = 690 Score = 75.9 bits (185), Expect = 4e-14 Identities = 72/281 (25%), Positives = 122/281 (43%), Gaps = 44/281 (15%) Query: 13 CPGLLRYTAYRCKQLSDTSII-----AVASHCPLLQKVHVGNQDKLTDEGLK--QLGSKC 65 CPG+L C LS+T+I + H LQ + + + TD+GL+ LG+ C Sbjct: 270 CPGVL------CLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGC 323 Query: 66 RELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGF 125 +L + C +IS +G IA C + + + + +TD VKA E C + + F Sbjct: 324 HKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVF 383 Query: 126 MGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRC 185 G S R LS+ LR I N+ V D Sbjct: 384 TGAPHISD-----CTFRALSACKLRKIRFEGNKRV---------------------TDAS 417 Query: 186 VEVIAKEGQNLKELYLVSCK-ITDYALIAIGRYSMTIETVDVGWCKEITDQGAT--LIAQ 242 + I K NL +Y+ CK ITD +L ++ + +++ C I D G L Sbjct: 418 FKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQ-LTVLNLANCVRIGDMGLKQFLDGP 476 Query: 243 SSKSLRYLGLMRCDKVNEVTVEQLVQQYPHITFSTVLQDCK 283 +S +R L L C ++++ +V +L ++ P++ + + L++C+ Sbjct: 477 ASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLS-LRNCE 516 Score = 73.6 bits (179), Expect = 2e-13 Identities = 58/256 (22%), Positives = 119/256 (46%), Gaps = 27/256 (10%) Query: 25 KQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEGM 84 K+++D S + + P L +++ + +TD L+ L S ++L ++ C +I D G+ Sbjct: 411 KRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSL-SPLKQLTVLNLANCVRIGDMGL 469 Query: 85 IVIAKG--CLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCS-VTSKGVIHLTKL 141 G ++++ + + ++D SV +E CP L Y+ C +T++G+ ++ + Sbjct: 470 KQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNI 529 Query: 142 RNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYL 201 +L S+DL T++ NE + ++ R K L L++ + I D ++ Sbjct: 530 FSLVSIDLSG-TDISNEG-LNVLSRHKKLKELSVSECYRITDDGIQ-------------- 573 Query: 202 VSCKITDYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEV 261 ITD A+ + + +D+ C +TDQ + K LR L + C +++ Sbjct: 574 ----ITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKK 629 Query: 262 TVEQL---VQQYPHIT 274 +++ VQQ + T Sbjct: 630 AAQRMSSKVQQQEYNT 645 Score = 53.5 bits (127), Expect = 2e-07 Identities = 40/155 (25%), Positives = 73/155 (47%), Gaps = 4/155 (2%) Query: 123 VGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIIN 182 + F GC + K ++ RNL L++ +E++ I + C + LNL N I Sbjct: 226 LNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLS-NTTIT 284 Query: 183 DRCVEVIAKEGQNLKELYLVSC-KITDYAL--IAIGRYSMTIETVDVGWCKEITDQGATL 239 +R + ++ + NL+ L L C + TD L + +G + +D+ C +I+ QG Sbjct: 285 NRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRY 344 Query: 240 IAQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHIT 274 IA S + +L + + + V+ LV++ IT Sbjct: 345 IANSCTGIMHLTINDMPTLTDNCVKALVEKCSRIT 379 Score = 45.4 bits (106), Expect = 6e-05 Identities = 35/141 (24%), Positives = 65/141 (46%), Gaps = 32/141 (22%) Query: 24 CKQLSDTSIIAVASHCPLLQKVHVGNQDKLT------------------------DEGLK 59 C +LSD S++ ++ CP L + + N + LT +EGL Sbjct: 489 CVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLN 548 Query: 60 QLGSKCRELKDIHFGQCYKISDEG-------MIVIAKGCLKLQRIYMQENKLVTDQSVKA 112 L S+ ++LK++ +CY+I+D+G M +++ C L + + L+TDQ ++ Sbjct: 549 VL-SRHKKLKELSVSECYRITDDGIQITDSAMEMLSAKCHYLHILDISGCVLLTDQILED 607 Query: 113 FAEHCPELQYVGFMGCSVTSK 133 C +L+ + C+ SK Sbjct: 608 LQIGCKQLRILKMQYCTNISK 628 Score = 33.1 bits (74), Expect = 0.31 Identities = 29/152 (19%), Positives = 62/152 (40%), Gaps = 30/152 (19%) Query: 1 MSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSI-----------------------IAVAS 37 +SD V L+ +CP L + C+ L+ I + V S Sbjct: 492 LSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLS 551 Query: 38 HCPLLQKVHVGNQDKLTDEGLK-------QLGSKCRELKDIHFGQCYKISDEGMIVIAKG 90 L+++ V ++TD+G++ L +KC L + C ++D+ + + G Sbjct: 552 RHKKLKELSVSECYRITDDGIQITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIG 611 Query: 91 CLKLQRIYMQENKLVTDQSVKAFAEHCPELQY 122 C +L+ + MQ ++ ++ + + + +Y Sbjct: 612 CKQLRILKMQYCTNISKKAAQRMSSKVQQQEY 643 >gi|164663798 antagonist of mitotic exit network 1 homolog [Homo sapiens] Length = 258 Score = 73.6 bits (179), Expect = 2e-13 Identities = 49/174 (28%), Positives = 86/174 (49%), Gaps = 8/174 (4%) Query: 23 RCKQLSDTSIIAVASHCPLLQKVHV----GNQDKLTDEGLKQLGSKCRELKDIHFGQCYK 78 R +SD +++ + S+C L+K+++ GN+ +T EG+K + S C L + +C Sbjct: 69 RSCDISDAALLHL-SNCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLHEASLKRCCN 127 Query: 79 ISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHL 138 ++DEG++ +A C L+ I + +TD S+ A ++CP LQ V F V+ GVI L Sbjct: 128 LTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFSATQVSDSGVIAL 187 Query: 139 TK---LRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVI 189 + L + + H L + V ++ C + L +I D EV+ Sbjct: 188 VSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLITDHSREVL 241 Score = 70.9 bits (172), Expect = 1e-12 Identities = 40/130 (30%), Positives = 70/130 (53%), Gaps = 3/130 (2%) Query: 1 MSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQ 60 ++ G+ +A C L + RC L+D ++A+A +C LL+ + +G +TD L Sbjct: 102 VTSEGIKAVASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHA 161 Query: 61 LGSKCRELKDIHFGQCYKISDEGMIVIAKG--CLKLQRIYMQENKLVTDQSVKAFAEHCP 118 LG C L+ + F ++SD G+I + G KL+ I+M +TD +V+A +CP Sbjct: 162 LGKNCPFLQCVDF-SATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCP 220 Query: 119 ELQYVGFMGC 128 +++ + F GC Sbjct: 221 QIRILLFHGC 230 Score = 46.2 bits (108), Expect = 4e-05 Identities = 46/198 (23%), Positives = 79/198 (39%), Gaps = 38/198 (19%) Query: 105 VTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLR----HITELDNETV 160 +TD ++ PE+Q + C ++ ++HL+ R L L+L + + +E + Sbjct: 50 ITDSNISEILH--PEVQTLDLRSCDISDAALLHLSNCRKLKKLNLNASKGNRVSVTSEGI 107 Query: 161 MEIVKRCKNL--SSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSC-KITDYALIAIGR- 216 + C L +SL C N + D V +A Q LK + L C ITD +L A+G+ Sbjct: 108 KAVASSCSYLHEASLKRCCN--LTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKN 165 Query: 217 --------YSMT------------------IETVDVGWCKEITDQGATLIAQSSKSLRYL 250 +S T +E + +G C +TD + +R L Sbjct: 166 CPFLQCVDFSATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRIL 225 Query: 251 GLMRCDKVNEVTVEQLVQ 268 C + + + E L Q Sbjct: 226 LFHGCPLITDHSREVLEQ 243 >gi|190194416 F-box and leucine-rich repeat protein 15 [Homo sapiens] Length = 300 Score = 66.2 bits (160), Expect = 3e-11 Identities = 47/169 (27%), Positives = 84/169 (49%), Gaps = 3/169 (1%) Query: 1 MSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQ 60 +SD + + + P L C QLS ++ A+A CP LQ++ + + D + L+ Sbjct: 101 LSDEDLVPVLARNPQLRSVALGGCGQLSRRALGALAEGCPRLQRLSLAHCDWVDGLALRG 160 Query: 61 LGSKCRELKDIHFGQCYKISDEGMIVIA-KGCLKLQRIYMQENKLVTDQSVKAFAEHCPE 119 L +C L+++ C ++ DE ++ +A + L+ + + N V D +V+ A +CPE Sbjct: 161 LADRCPALEELDLTACRQLKDEAIVYLAQRRGAGLRSLSLAVNANVGDAAVQELARNCPE 220 Query: 120 LQYVGFMGC-SVTSKGVIHLTK-LRNLSSLDLRHITELDNETVMEIVKR 166 L ++ GC V S GV L + L SL +RH + ++ + KR Sbjct: 221 LHHLDLTGCLRVGSDGVRTLAEYCPVLRSLRVRHCHHVAESSLSRLRKR 269 Score = 46.6 bits (109), Expect = 3e-05 Identities = 43/202 (21%), Positives = 84/202 (41%), Gaps = 27/202 (13%) Query: 68 LKDIHFGQCYK-ISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFM 126 L+++ C++ +SDE ++ + +L+ + + ++ +++ A AE CP LQ Sbjct: 89 LQELALAPCHEWLSDEDLVPVLARNPQLRSVALGGCGQLSRRALGALAEGCPRLQ----- 143 Query: 127 GCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCV 186 L L H +D + + RC L L+L + D + Sbjct: 144 -------------------RLSLAHCDWVDGLALRGLADRCPALEELDLTACRQLKDEAI 184 Query: 187 EVIA-KEGQNLKELYL-VSCKITDYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSS 244 +A + G L+ L L V+ + D A+ + R + +D+ C + G +A+ Sbjct: 185 VYLAQRRGAGLRSLSLAVNANVGDAAVQELARNCPELHHLDLTGCLRVGSDGVRTLAEYC 244 Query: 245 KSLRYLGLMRCDKVNEVTVEQL 266 LR L + C V E ++ +L Sbjct: 245 PVLRSLRVRHCHHVAESSLSRL 266 Score = 35.0 bits (79), Expect = 0.082 Identities = 19/85 (22%), Positives = 43/85 (50%), Gaps = 2/85 (2%) Query: 189 IAKEGQNLKELYLVSCK--ITDYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKS 246 + ++ + L+EL L C ++D L+ + + + +V +G C +++ + +A+ Sbjct: 82 LLRDAEGLQELALAPCHEWLSDEDLVPVLARNPQLRSVALGGCGQLSRRALGALAEGCPR 141 Query: 247 LRYLGLMRCDKVNEVTVEQLVQQYP 271 L+ L L CD V+ + + L + P Sbjct: 142 LQRLSLAHCDWVDGLALRGLADRCP 166 >gi|16306588 F-box and leucine-rich repeat protein 4 [Homo sapiens] Length = 621 Score = 63.2 bits (152), Expect = 3e-10 Identities = 42/184 (22%), Positives = 84/184 (45%), Gaps = 33/184 (17%) Query: 12 KCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGL--KQLGSKCRELK 69 K L R YR K + T+++++ + C LQ + +G+ + D + +G+KC++L+ Sbjct: 424 KLCSLKRLVLYRTK-VEQTALLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLR 482 Query: 70 DIHFGQCYKISDEGMIVIAKGCL----------------------------KLQRIYMQE 101 + +C I++ G+ +A GC LQ++++ Sbjct: 483 TLDLWRCKNITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTA 542 Query: 102 NKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIH--LTKLRNLSSLDLRHITELDNET 159 N+ V D + A +C LQ + +G + S + L ++LS LD+ +++DN Sbjct: 543 NRSVCDTDIDELACNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRA 602 Query: 160 VMEI 163 V+E+ Sbjct: 603 VLEL 606 Score = 60.8 bits (146), Expect = 1e-09 Identities = 68/266 (25%), Positives = 117/266 (43%), Gaps = 22/266 (8%) Query: 14 PGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQD---KLTDEGLKQLGSKCRELKD 70 P L R A CK LS C LQ +H+ Q KL D L+ L S+C ++ Sbjct: 298 PDLCRL-AQTCKLLSQHC-------CDPLQYIHLNLQPYWAKLDDTSLEFLQSRCTLVQW 349 Query: 71 IHF---GQCYKISDEGMIVIAKGC-LKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFM 126 ++ G IS G K C +L R+ + + + + ++ +E CP LQ + Sbjct: 350 LNLSWTGNRGFISVAGFSRFLKVCGSELVRLELSCSHFLNETCLEVISEMCPNLQALNLS 409 Query: 127 GC-SVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNL--CLNWIIND 183 C + + H+ KL +L L L + T+++ ++ I+ C L L+L C+ D Sbjct: 410 SCDKLPPQAFNHIAKLCSLKRLVL-YRTKVEQTALLSILNFCSELQHLSLGSCVMIEDYD 468 Query: 184 RCVEVIAKEGQNLKELYLVSCK-ITDYALIAIGRYSMTIETVDVGWCKEITDQGA--TLI 240 +I + + L+ L L CK IT+ + + +E +D+GWC + T + Sbjct: 469 VIASMIGAKCKKLRTLDLWRCKNITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRL 528 Query: 241 AQSSKSLRYLGLMRCDKVNEVTVEQL 266 A +L+ L L V + +++L Sbjct: 529 AHQLPNLQKLFLTANRSVCDTDIDEL 554 Score = 50.4 bits (119), Expect = 2e-06 Identities = 46/250 (18%), Positives = 102/250 (40%), Gaps = 27/250 (10%) Query: 27 LSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEGMIV 86 L++T + ++ CP LQ +++ + DKL + + C + + + K+ ++ Sbjct: 388 LNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIAKLCSLKRLVLYRT--KVEQTALLS 445 Query: 87 IAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHLTKLRNLSS 146 I C +LQ + + ++ D V A +G K + L + Sbjct: 446 ILNFCSELQHLSLGSCVMIEDYDVIA--------SMIG--------------AKCKKLRT 483 Query: 147 LDLRHITELDNETVMEIVKRCKNLSSLNL--CLNWIINDRCVEVIAKEGQNLKELYLVSC 204 LDL + + E+ C L L+L C + C +A + NL++L+L + Sbjct: 484 LDLWRCKNITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTAN 543 Query: 205 K-ITDYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTV 263 + + D + + ++ +D+ + ++ + +S K L L + C +++ V Sbjct: 544 RSVCDTDIDELACNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAV 603 Query: 264 EQLVQQYPHI 273 +L +P + Sbjct: 604 LELNASFPKV 613 Score = 45.1 bits (105), Expect = 8e-05 Identities = 38/160 (23%), Positives = 63/160 (39%), Gaps = 41/160 (25%) Query: 170 LSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSC------------------------- 204 L L L + +N+ C+EVI++ NL+ L L SC Sbjct: 377 LVRLELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIAKLCSLKRLVLYRT 436 Query: 205 KITDYALIAIGRYSMTIETVDVGWCKEITDQG--ATLIAQSSKSLRYLGLMRCDKVNEVT 262 K+ AL++I + ++ + +G C I D A++I K LR L L RC + E Sbjct: 437 KVEQTALLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENG 496 Query: 263 VEQLVQQYPHITFSTVLQDCKRTLERAYQMGWTPNMSAAS 302 + +L P L +GW P + +++ Sbjct: 497 IAELASGCP--------------LLEELDLGWCPTLQSST 522 >gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens] Length = 479 Score = 59.3 bits (142), Expect = 4e-09 Identities = 53/218 (24%), Positives = 104/218 (47%), Gaps = 6/218 (2%) Query: 53 LTDEGLKQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKA 112 +TD GL+ + + + + + C ++ G+ ++ + + + V D ++ A Sbjct: 205 ITDAGLEVMLEQMQGVVRLELSGCNDFTEAGLWSSLSA--RITSLSVSDCINVADDAIAA 262 Query: 113 FAEHCPELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHIT--ELDNETVMEIVKRCKNL 170 ++ P L + VT + + T + S+ LR ++ E+ N V+ +V NL Sbjct: 263 ISQLLPNLAELSLQAYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNL 322 Query: 171 SSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSC-KITDYALIAIGRYSMTIETVDVGWC 229 ++L+L + D VE++A+ + L+ L L C +ITD AL + +E + + C Sbjct: 323 TALSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLDRC 382 Query: 230 KEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQLV 267 ITD G + ++ S SLR L L C +V + ++ L+ Sbjct: 383 VRITDTGLSYLSTMS-SLRSLYLRWCCQVQDFGLKHLL 419 Score = 58.2 bits (139), Expect = 9e-09 Identities = 37/181 (20%), Positives = 84/181 (46%), Gaps = 2/181 (1%) Query: 105 VTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIV 164 +TD ++ E + + GC+ ++ + + ++SL + + ++ + I Sbjct: 205 ITDAGLEVMLEQMQGVVRLELSGCNDFTEAGLWSSLSARITSLSVSDCINVADDAIAAIS 264 Query: 165 KRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSC-KITDYALIAIGRYSMTIET 223 + NL+ L+L + + A++G + L L+SC +IT++ ++ + + Sbjct: 265 QLLPNLAELSLQAYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNLTA 324 Query: 224 VDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHITFSTVLQDCK 283 + + C ++TD G L+A++ + LR L L C ++ ++ +E + H VL C Sbjct: 325 LSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDL-HRLEELVLDRCV 383 Query: 284 R 284 R Sbjct: 384 R 384 Score = 42.0 bits (97), Expect = 7e-04 Identities = 32/150 (21%), Positives = 72/150 (48%), Gaps = 3/150 (2%) Query: 1 MSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQ 60 ++++GV + P L + C +++D + VA + L+ + + ++TD L+ Sbjct: 307 ITNHGVVNVVHSLPNLTALSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEY 366 Query: 61 LGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPEL 120 + L+++ +C +I+D G+ ++ L+ +Y++ V D +K L Sbjct: 367 VACDLHRLEELVLDRCVRITDTGLSYLST-MSSLRSLYLRWCCQVQDFGLKHLLA-LGSL 424 Query: 121 QYVGFMGCS-VTSKGVIHLTKLRNLSSLDL 149 + + GC +T+ G+ L +L+ L L+L Sbjct: 425 RLLSPAGCPLLTTTGLSGLVQLQELEELEL 454 Score = 40.8 bits (94), Expect = 0.001 Identities = 25/124 (20%), Positives = 54/124 (43%) Query: 24 CKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEG 83 C ++++ ++ V P L + + K+TD+G++ + R+L+ + C +I+D Sbjct: 304 CWEITNHGVVNVVHSLPNLTALSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMA 363 Query: 84 MIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHLTKLRN 143 + +A +L+ + + +TD + + C V G+ HL L + Sbjct: 364 LEYVACDLHRLEELVLDRCVRITDTGLSYLSTMSSLRSLYLRWCCQVQDFGLKHLLALGS 423 Query: 144 LSSL 147 L L Sbjct: 424 LRLL 427 >gi|51873034 F-box and leucine-rich repeat protein 9 [Homo sapiens] Length = 223 Score = 48.1 bits (113), Expect = 9e-06 Identities = 23/76 (30%), Positives = 39/76 (51%) Query: 1 MSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQ 60 ++DNG+ +A CP L C +LSD AS P LQ +++ + +L ++ L Sbjct: 113 LTDNGLVAVARGCPSLEHLALSHCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDA 172 Query: 61 LGSKCRELKDIHFGQC 76 +G CR+L+ + C Sbjct: 173 IGQACRQLRVLDVATC 188 Score = 45.8 bits (107), Expect = 5e-05 Identities = 26/105 (24%), Positives = 49/105 (46%), Gaps = 1/105 (0%) Query: 24 CKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEG 83 C +L+D S+ V L Q + + +LTD GL + C L+ + C ++SD+G Sbjct: 85 CSKLTDASLAKVLQFLQLRQ-LSLSLLPELTDNGLVAVARGCPSLEHLALSHCSRLSDKG 143 Query: 84 MIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGC 128 A +LQ + + + +Q++ A + C +L+ + C Sbjct: 144 WAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATC 188 Score = 45.4 bits (106), Expect = 6e-05 Identities = 22/98 (22%), Positives = 51/98 (52%) Query: 26 QLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEGMI 85 +L+D ++AVA CP L+ + + + +L+D+G Q S L+ ++ C ++ ++ + Sbjct: 112 ELTDNGLVAVARGCPSLEHLALSHCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLD 171 Query: 86 VIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYV 123 I + C +L+ + + + +V+ F P++ V Sbjct: 172 AIGQACRQLRVLDVATCPGINMAAVRRFQAQLPQVSCV 209 Score = 42.7 bits (99), Expect = 4e-04 Identities = 26/96 (27%), Positives = 51/96 (53%), Gaps = 5/96 (5%) Query: 196 LKELYLVSC-KITDYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMR 254 L+EL L +C K+TD +L + ++ + + + + E+TD G +A+ SL +L L Sbjct: 77 LQELDLTACSKLTDASLAKVLQF-LQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSH 135 Query: 255 CDKVNEVTVEQLVQQYP---HITFSTVLQDCKRTLE 287 C ++++ Q +P H+ S+ Q ++TL+ Sbjct: 136 CSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLD 171 Score = 40.4 bits (93), Expect = 0.002 Identities = 21/88 (23%), Positives = 45/88 (51%), Gaps = 1/88 (1%) Query: 42 LQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQE 101 LQ++ + KLTD L ++ + +L+ + +++D G++ +A+GC L+ + + Sbjct: 77 LQELDLTACSKLTDASLAKV-LQFLQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSH 135 Query: 102 NKLVTDQSVKAFAEHCPELQYVGFMGCS 129 ++D+ A P LQ++ CS Sbjct: 136 CSRLSDKGWAQAASSWPRLQHLNLSSCS 163 Score = 37.7 bits (86), Expect = 0.013 Identities = 18/64 (28%), Positives = 36/64 (56%) Query: 205 KITDYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVE 264 ++TD L+A+ R ++E + + C ++D+G A S L++L L C ++ E T++ Sbjct: 112 ELTDNGLVAVARGCPSLEHLALSHCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLD 171 Query: 265 QLVQ 268 + Q Sbjct: 172 AIGQ 175 >gi|16306591 F-box and leucine-rich repeat protein 9 [Homo sapiens] Length = 223 Score = 48.1 bits (113), Expect = 9e-06 Identities = 23/76 (30%), Positives = 39/76 (51%) Query: 1 MSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQ 60 ++DNG+ +A CP L C +LSD AS P LQ +++ + +L ++ L Sbjct: 113 LTDNGLVAVARGCPSLEHLALSHCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDA 172 Query: 61 LGSKCRELKDIHFGQC 76 +G CR+L+ + C Sbjct: 173 IGQACRQLRVLDVATC 188 Score = 45.8 bits (107), Expect = 5e-05 Identities = 26/105 (24%), Positives = 49/105 (46%), Gaps = 1/105 (0%) Query: 24 CKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEG 83 C +L+D S+ V L Q + + +LTD GL + C L+ + C ++SD+G Sbjct: 85 CSKLTDASLAKVLQFLQLRQ-LSLSLLPELTDNGLVAVARGCPSLEHLALSHCSRLSDKG 143 Query: 84 MIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGC 128 A +LQ + + + +Q++ A + C +L+ + C Sbjct: 144 WAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATC 188 Score = 45.4 bits (106), Expect = 6e-05 Identities = 22/98 (22%), Positives = 51/98 (52%) Query: 26 QLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEGMI 85 +L+D ++AVA CP L+ + + + +L+D+G Q S L+ ++ C ++ ++ + Sbjct: 112 ELTDNGLVAVARGCPSLEHLALSHCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLD 171 Query: 86 VIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYV 123 I + C +L+ + + + +V+ F P++ V Sbjct: 172 AIGQACRQLRVLDVATCPGINMAAVRRFQAQLPQVSCV 209 Score = 42.7 bits (99), Expect = 4e-04 Identities = 26/96 (27%), Positives = 51/96 (53%), Gaps = 5/96 (5%) Query: 196 LKELYLVSC-KITDYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMR 254 L+EL L +C K+TD +L + ++ + + + + E+TD G +A+ SL +L L Sbjct: 77 LQELDLTACSKLTDASLAKVLQF-LQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSH 135 Query: 255 CDKVNEVTVEQLVQQYP---HITFSTVLQDCKRTLE 287 C ++++ Q +P H+ S+ Q ++TL+ Sbjct: 136 CSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLD 171 Score = 40.4 bits (93), Expect = 0.002 Identities = 21/88 (23%), Positives = 45/88 (51%), Gaps = 1/88 (1%) Query: 42 LQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQE 101 LQ++ + KLTD L ++ + +L+ + +++D G++ +A+GC L+ + + Sbjct: 77 LQELDLTACSKLTDASLAKV-LQFLQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSH 135 Query: 102 NKLVTDQSVKAFAEHCPELQYVGFMGCS 129 ++D+ A P LQ++ CS Sbjct: 136 CSRLSDKGWAQAASSWPRLQHLNLSSCS 163 Score = 37.7 bits (86), Expect = 0.013 Identities = 18/64 (28%), Positives = 36/64 (56%) Query: 205 KITDYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVE 264 ++TD L+A+ R ++E + + C ++D+G A S L++L L C ++ E T++ Sbjct: 112 ELTDNGLVAVARGCPSLEHLALSHCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLD 171 Query: 265 QLVQ 268 + Q Sbjct: 172 AIGQ 175 >gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens] Length = 1162 Score = 41.2 bits (95), Expect = 0.001 Identities = 38/176 (21%), Positives = 76/176 (43%), Gaps = 20/176 (11%) Query: 118 PELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCL 177 P L+ + GCS ++ + + L +LDLR + + + +++ Sbjct: 977 PGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIRDLLTPPA--------- 1027 Query: 178 NWIINDRCVEVIAKEGQNLKELYLVSCKITDYALIAIGRYSMTIETVDVGWCKEITDQGA 237 D+ + + +N+ + L ITD L I R+ + +D+ C +TDQ + Sbjct: 1028 -----DKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSS 1082 Query: 238 TLIAQSSKSLRY----LGLMRCDKVNEVTVEQLVQQYPHITFSTVLQDCKRTLERA 289 L+ S RY L + C+K+ + T+ L ++ ++T L+ CK+ +A Sbjct: 1083 NLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYL-RRIANVTLID-LRGCKQITRKA 1136 Score = 33.1 bits (74), Expect = 0.31 Identities = 17/67 (25%), Positives = 37/67 (55%), Gaps = 4/67 (5%) Query: 27 LSDTSIIAVASHCPLLQKVHVGNQDKLTDEG---LKQLGSKCR-ELKDIHFGQCYKISDE 82 ++D ++ + H PLL ++ + + LTD+ L +GS R L +++ C K++D+ Sbjct: 1051 ITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQ 1110 Query: 83 GMIVIAK 89 +I + + Sbjct: 1111 TLIYLRR 1117 >gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [Homo sapiens] Length = 1265 Score = 41.2 bits (95), Expect = 0.001 Identities = 30/112 (26%), Positives = 53/112 (47%), Gaps = 8/112 (7%) Query: 27 LSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQL---GSKCRE-LKDIHFGQCYKISDE 82 ++D S+ + H PLL K+H+ + +TD+ + L G+ R+ L +I+ C K++D+ Sbjct: 1156 ITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQ 1215 Query: 83 GMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKG 134 + K C + I ++ K VT + + F Q CS T G Sbjct: 1216 -CLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSSFQ---GRSCSTTRLG 1263 Score = 36.2 bits (82), Expect = 0.037 Identities = 21/71 (29%), Positives = 35/71 (49%), Gaps = 4/71 (5%) Query: 194 QNLKELYLVSCKITDYALIAIGRYSMTIETVDVGWCKEITDQGATLI----AQSSKSLRY 249 +N+ EL L ITD +L I R+ + + + +C +TDQ L+ + SL Sbjct: 1144 RNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTE 1203 Query: 250 LGLMRCDKVNE 260 + L C+KV + Sbjct: 1204 INLSDCNKVTD 1214 >gi|5453880 acidic (leucine-rich) nuclear phosphoprotein 32 family, member A [Homo sapiens] Length = 249 Score = 40.0 bits (92), Expect = 0.003 Identities = 30/111 (27%), Positives = 57/111 (51%), Gaps = 11/111 (9%) Query: 101 ENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNET- 159 +N + ++ + EL+++ + +TS + +L KL L L+L DN Sbjct: 25 DNSRSNEGKLEGLTDEFEELEFLSTINVGLTS--IANLPKLNKLKKLELS-----DNRVS 77 Query: 160 --VMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITD 208 + + ++C NL+ LNL N I + +E + K+ +NLK L L +C++T+ Sbjct: 78 GGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPL-KKLENLKSLDLFNCEVTN 127 >gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [Homo sapiens] Length = 1336 Score = 40.0 bits (92), Expect = 0.003 Identities = 28/101 (27%), Positives = 53/101 (52%), Gaps = 6/101 (5%) Query: 27 LSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQL---GSKCRE-LKDIHFGQCYKISDE 82 ++D S+ + H PLL K+H+ + +TD+ + L G+ R+ L +I+ C K++D+ Sbjct: 1225 ITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQ 1284 Query: 83 GMIVIAKGCLKLQRIYMQENKLVTDQSVKAF-AEHCPELQY 122 + K C + I ++ K VT + + F AE +Q+ Sbjct: 1285 -CLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSVSVQF 1324 Score = 36.2 bits (82), Expect = 0.037 Identities = 21/71 (29%), Positives = 35/71 (49%), Gaps = 4/71 (5%) Query: 194 QNLKELYLVSCKITDYALIAIGRYSMTIETVDVGWCKEITDQGATLI----AQSSKSLRY 249 +N+ EL L ITD +L I R+ + + + +C +TDQ L+ + SL Sbjct: 1213 RNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTE 1272 Query: 250 LGLMRCDKVNE 260 + L C+KV + Sbjct: 1273 INLSDCNKVTD 1283 >gi|13569879 acidic (leucine-rich) nuclear phosphoprotein 32 family, member E isoform 1 [Homo sapiens] Length = 268 Score = 37.0 bits (84), Expect = 0.022 Identities = 24/87 (27%), Positives = 46/87 (52%), Gaps = 7/87 (8%) Query: 93 KLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIH-LTKLRNLSSLDLRH 151 KL+++ + +N + ++ AE CP L Y+ G + + L L+NL SLDL + Sbjct: 65 KLRKLELSDN--IISGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDLFN 122 Query: 152 --ITELDN--ETVMEIVKRCKNLSSLN 174 IT L++ E++ E++++ L + Sbjct: 123 CEITNLEDYRESIFELLQQITYLDGFD 149 Score = 35.0 bits (79), Expect = 0.082 Identities = 31/112 (27%), Positives = 57/112 (50%), Gaps = 13/112 (11%) Query: 101 ENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETV 160 +N L + ++ + EL+++ S + L+ L L SL+ EL + + Sbjct: 25 DNCLCVNGEIEGLNDTFKELEFL--------SMANVELSSLARLPSLNKLRKLELSDNII 76 Query: 161 ---MEIV-KRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITD 208 +E++ ++C NL+ LNL N I + VE + + +NLK L L +C+IT+ Sbjct: 77 SGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEAL-QNLKNLKSLDLFNCEITN 127 >gi|210147571 acidic (leucine-rich) nuclear phosphoprotein 32 family, member E isoform 3 [Homo sapiens] Length = 220 Score = 37.0 bits (84), Expect = 0.022 Identities = 24/87 (27%), Positives = 46/87 (52%), Gaps = 7/87 (8%) Query: 93 KLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIH-LTKLRNLSSLDLRH 151 KL+++ + +N + ++ AE CP L Y+ G + + L L+NL SLDL + Sbjct: 17 KLRKLELSDN--IISGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDLFN 74 Query: 152 --ITELDN--ETVMEIVKRCKNLSSLN 174 IT L++ E++ E++++ L + Sbjct: 75 CEITNLEDYRESIFELLQQITYLDGFD 101 Score = 34.3 bits (77), Expect = 0.14 Identities = 26/77 (33%), Positives = 44/77 (57%), Gaps = 5/77 (6%) Query: 136 IHLTKLRNLSSLDLRHITELDNETV---MEIV-KRCKNLSSLNLCLNWIINDRCVEVIAK 191 + L+ L L SL+ EL + + +E++ ++C NL+ LNL N I + VE + + Sbjct: 4 VELSSLARLPSLNKLRKLELSDNIISGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEAL-Q 62 Query: 192 EGQNLKELYLVSCKITD 208 +NLK L L +C+IT+ Sbjct: 63 NLKNLKSLDLFNCEITN 79 >gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] Length = 1093 Score = 35.8 bits (81), Expect = 0.048 Identities = 49/219 (22%), Positives = 92/219 (42%), Gaps = 32/219 (14%) Query: 51 DKLTDEGLKQLGSKCRELKDIHFGQCY--KISDEGMIVIAKGCLKLQRIYMQENKLVTDQ 108 + L D+G++ L R K CY ++S E + GC L + +L Sbjct: 796 NNLLDDGVQLLCEALRHPK------CYLERLSLESCGLTEAGCEYLSLALISNKRLT--- 846 Query: 109 SVKAFAEHCPELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLR--HITELDNETVMEIVKR 166 C +G G + S + H L SL LR H T L +E + + Sbjct: 847 ------HLCLADNVLGDGGVKLMSDALQHAQC--TLKSLVLRRCHFTSLSSEYLSTSLLH 898 Query: 167 CKNLSSLNLCLNWIIND---RCVEVIAKEGQNLKELYLVSCKITDYALIAIGRYSM---T 220 K+L+ L+L NW+ ++ +V NL++L L+ C +T+ + + + Sbjct: 899 NKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPN 958 Query: 221 IETVDVGWCKEITDQGATLIAQSSK----SLRYLGLMRC 255 + ++D+G ++ D G ++ + + +++ LGL C Sbjct: 959 LRSLDLG-NNDLQDDGVKILCDALRYPNCNIQRLGLEYC 996 >gi|6912604 acidic nuclear phosphoprotein 32C [Homo sapiens] Length = 234 Score = 34.7 bits (78), Expect = 0.11 Identities = 30/108 (27%), Positives = 57/108 (52%), Gaps = 9/108 (8%) Query: 101 ENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETV 160 +N + ++A + EL+++ + +TS + L KL+ L L+LR L+ Sbjct: 25 DNSRSNEGKLEALTDEFEELEFLSKINGGLTS--ISDLPKLK-LRKLELRVSGGLE---- 77 Query: 161 MEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITD 208 + ++C NL+ L L N I + +E + K+ +NLK L L +C++T+ Sbjct: 78 -VLAEKCPNLTHLYLSGNKIKDLSTIEPL-KQLENLKSLDLFNCEVTN 123 Score = 30.8 bits (68), Expect = 1.5 Identities = 24/86 (27%), Positives = 42/86 (48%), Gaps = 4/86 (4%) Query: 94 LQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIH-LTKLRNLSSLDLRH- 151 L ++ +++ +L ++ AE CP L ++ G + I L +L NL SLDL + Sbjct: 60 LPKLKLRKLELRVSGGLEVLAEKCPNLTHLYLSGNKIKDLSTIEPLKQLENLKSLDLFNC 119 Query: 152 -ITELDNETVMEIVKRCKNLSSLNLC 176 +T L N+ + K L+ L+ C Sbjct: 120 EVTNL-NDYGENVFKLLLQLTYLDSC 144 >gi|8923179 F-box and leucine-rich repeat protein 12 [Homo sapiens] Length = 326 Score = 33.9 bits (76), Expect = 0.18 Identities = 29/137 (21%), Positives = 64/137 (46%), Gaps = 2/137 (1%) Query: 40 PLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYM 99 PLL+ + + DE L+ L ++ R L+ + G Y++++ G+ + LQR+ + Sbjct: 151 PLLECIVLDRVPAFRDEHLQGL-TRFRALRSLVLGGTYRVTETGLDAGLQELSYLQRLEV 209 Query: 100 QENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLR-HITELDNE 158 L D ++ A + H +++ + +++ G+ L + L SL L+ + + Sbjct: 210 LGCTLSADSTLLAISRHLRDVRKIRLTVRGLSAPGLAVLEGMPALESLCLQGPLVTPEMP 269 Query: 159 TVMEIVKRCKNLSSLNL 175 + EI+ C + L + Sbjct: 270 SPTEILSSCLTMPKLRV 286 >gi|16306584 F-box and leucine-rich repeat protein 3 [Homo sapiens] Length = 428 Score = 33.5 bits (75), Expect = 0.24 Identities = 26/105 (24%), Positives = 48/105 (45%), Gaps = 3/105 (2%) Query: 22 YRCKQLSDTSIIAVASHCP-LLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKIS 80 Y + +S + V CP L++ V N + DE L ++ +C+ L I G+C ++S Sbjct: 314 YFGRSVSKDVLGRVGMTCPRLVELVVCANGLRPLDEELIRIAERCKNLSAIGLGEC-EVS 372 Query: 81 DEGMIVIAKGC-LKLQRIYMQENKLVTDQSVKAFAEHCPELQYVG 124 + K C +L ++ + E L+ DQ H +++G Sbjct: 373 CSAFVEFVKMCGGRLSQLSIMEEVLIPDQKYSLEQIHWEVSKHLG 417 >gi|116268109 nucleotide-binding oligomerization domains 27 [Homo sapiens] Length = 1866 Score = 32.7 bits (73), Expect = 0.41 Identities = 25/101 (24%), Positives = 46/101 (45%), Gaps = 12/101 (11%) Query: 90 GCLKLQRIYMQENKLVTDQSVKAFAEHCP---ELQYVGFMGCSVTSKGVIHLTKLRNLSS 146 GC +++ + + K D +A + P LQ +G G +T++G+ HL K L Sbjct: 684 GCGQIENLSFKSRKC-GDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCP 742 Query: 147 LDLRHITELDNE-------TVMEIVKRCKNLSSLNLCLNWI 180 L+ ++ DN+ ++E++ L L+L N I Sbjct: 743 -QLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSI 782 >gi|55742693 zyg-11 homolog B [Homo sapiens] Length = 744 Score = 32.3 bits (72), Expect = 0.53 Identities = 28/129 (21%), Positives = 63/129 (48%), Gaps = 5/129 (3%) Query: 132 SKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAK 191 ++ + + L L SLD+ + + D ++ R K+L+ +L + + ++V+ + Sbjct: 176 NEDLAEVASLPRLESLDISNTSITDITALLACKDRLKSLTMHHLKCLKMTTTQILDVV-R 234 Query: 192 EGQNLKELYLVSCK--ITDYALIAIGRYSM--TIETVDVGWCKEITDQGATLIAQSSKSL 247 E ++L L + K +D AL + + + + ++DV K +TD+ Q S+ Sbjct: 235 ELKHLNHLDISDDKQFTSDIALRLLEQKDILPNLVSLDVSGRKHVTDKAVEAFIQQRPSM 294 Query: 248 RYLGLMRCD 256 +++GL+ D Sbjct: 295 QFVGLLATD 303 >gi|16306574 F-box and leucine-rich repeat protein 5 isoform 2 [Homo sapiens] Length = 565 Score = 31.6 bits (70), Expect = 0.91 Identities = 21/74 (28%), Positives = 34/74 (45%), Gaps = 3/74 (4%) Query: 24 CKQLSDTS--IIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISD 81 C Q++D ++ + P L+ +++ +T GL+ L S C L D +F C I+ Sbjct: 482 CYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNING 541 Query: 82 EGMIVIAKGCLKLQ 95 A GC LQ Sbjct: 542 PHADT-ASGCQNLQ 554 >gi|16306572 F-box and leucine-rich repeat protein 5 isoform 1 [Homo sapiens] Length = 691 Score = 31.6 bits (70), Expect = 0.91 Identities = 21/74 (28%), Positives = 34/74 (45%), Gaps = 3/74 (4%) Query: 24 CKQLSDTS--IIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISD 81 C Q++D ++ + P L+ +++ +T GL+ L S C L D +F C I+ Sbjct: 608 CYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNING 667 Query: 82 EGMIVIAKGCLKLQ 95 A GC LQ Sbjct: 668 PHADT-ASGCQNLQ 680 >gi|16306576 F-box and leucine-rich repeat protein 6 isoform 1 [Homo sapiens] Length = 539 Score = 31.6 bits (70), Expect = 0.91 Identities = 21/61 (34%), Positives = 31/61 (50%), Gaps = 2/61 (3%) Query: 93 KLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGC-SVTSKGVIHLTK-LRNLSSLDLR 150 +LQR+ + K +K E CP L ++ GC VT+ ++ L K L SLDL+ Sbjct: 195 QLQRLTLIHWKSQVHPVLKLVGECCPRLTFLKLSGCHGVTADALVMLAKACCQLHSLDLQ 254 Query: 151 H 151 H Sbjct: 255 H 255 >gi|239754160 PREDICTED: similar to hCG1980490 [Homo sapiens] Length = 348 Score = 30.8 bits (68), Expect = 1.5 Identities = 26/75 (34%), Positives = 39/75 (52%), Gaps = 12/75 (16%) Query: 50 QDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQS 109 +D LTD GL QLG REL+ Q ++ ++ I I + KL+ ++++ + V D Sbjct: 199 EDTLTDSGLSQLGRALRELE----AQRQRLREQHQIWIRE---KLK--HLEQKEEVADDQ 249 Query: 110 VK---AFAEHCPELQ 121 VK A E C E Q Sbjct: 250 VKGLVAEEEACEERQ 264 >gi|239748674 PREDICTED: similar to hCG1980490 [Homo sapiens] Length = 348 Score = 30.8 bits (68), Expect = 1.5 Identities = 26/75 (34%), Positives = 39/75 (52%), Gaps = 12/75 (16%) Query: 50 QDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQS 109 +D LTD GL QLG REL+ Q ++ ++ I I + KL+ ++++ + V D Sbjct: 199 EDTLTDSGLSQLGRALRELE----AQRQRLREQHQIWIRE---KLK--HLEQKEEVADDQ 249 Query: 110 VK---AFAEHCPELQ 121 VK A E C E Q Sbjct: 250 VKGLVAEEEACEERQ 264 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.322 0.135 0.404 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 10,164,138 Number of Sequences: 37866 Number of extensions: 401455 Number of successful extensions: 1252 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 18 Number of HSP's successfully gapped in prelim test: 33 Number of HSP's that attempted gapping in prelim test: 998 Number of HSP's gapped (non-prelim): 131 length of query: 303 length of database: 18,247,518 effective HSP length: 102 effective length of query: 201 effective length of database: 14,385,186 effective search space: 2891422386 effective search space used: 2891422386 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.