Search of human proteins with 253735700

Search of human proteins with 253735700

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A
isoform b precursor [Homo sapiens]
         (484 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform...   981   0.0  
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform...   964   0.0  
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform...   930   0.0  
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor...   372   e-103
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]   294   1e-79
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]   284   1e-76
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi...   231   1e-60
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]    219   6e-57
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [...   216   4e-56
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [...   214   2e-55
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec...   213   2e-55
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]   213   4e-55
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec...   212   7e-55
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H...   208   8e-54
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ...   206   4e-53
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]     204   1e-52
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec...   202   4e-52
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]   202   7e-52
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre...   189   6e-48
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec...   186   3e-47
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr...   176   4e-44
gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ...   166   6e-41
gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p...   146   5e-35
gi|223468705 5-hydroxytryptamine receptor 3 subunit D isoform 1 ...   144   2e-34
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]              139   4e-33
gi|47519877 5-hydroxytryptamine receptor 3 subunit D isoform 2 [...   117   3e-26
gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]              113   3e-25
gi|206725456 zinc activated ligand-gated ion channel [Homo sapiens]   110   4e-24
gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Hom...    88   2e-17
gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo s...    86   6e-17

>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
           precursor [Homo sapiens]
          Length = 484

 Score =  981 bits (2536), Expect = 0.0
 Identities = 484/484 (100%), Positives = 484/484 (100%)

Query: 1   MLGKLAMLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRD 60
           MLGKLAMLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRD
Sbjct: 1   MLGKLAMLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRD 60

Query: 61  WRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDS 120
           WRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDS
Sbjct: 61  WRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDS 120

Query: 121 IWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLT 180
           IWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLT
Sbjct: 121 IWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLT 180

Query: 181 FTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKF 240
           FTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKF
Sbjct: 181 FTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKF 240

Query: 241 YVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDT 300
           YVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDT
Sbjct: 241 YVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDT 300

Query: 301 LPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWL 360
           LPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWL
Sbjct: 301 LPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWL 360

Query: 361 LCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLA 420
           LCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLA
Sbjct: 361 LCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLA 420

Query: 421 VCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSI 480
           VCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSI
Sbjct: 421 VCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSI 480

Query: 481 WQYA 484
           WQYA
Sbjct: 481 WQYA 484


>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
           precursor [Homo sapiens]
          Length = 516

 Score =  964 bits (2493), Expect = 0.0
 Identities = 484/516 (93%), Positives = 484/516 (93%), Gaps = 32/516 (6%)

Query: 1   MLGKLAMLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRD 60
           MLGKLAMLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRD
Sbjct: 1   MLGKLAMLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRD 60

Query: 61  WRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDS 120
           WRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDS
Sbjct: 61  WRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDS 120

Query: 121 IWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLT 180
           IWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLT
Sbjct: 121 IWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLT 180

Query: 181 FTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKF 240
           FTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKF
Sbjct: 181 FTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKF 240

Query: 241 YVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDT 300
           YVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDT
Sbjct: 241 YVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDT 300

Query: 301 LPATAIGTPLI--------------------------------GVYFVVCMALLVISLAE 328
           LPATAIGTPLI                                GVYFVVCMALLVISLAE
Sbjct: 301 LPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAE 360

Query: 329 TIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMG 388
           TIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMG
Sbjct: 361 TIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMG 420

Query: 389 NHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDW 448
           NHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDW
Sbjct: 421 NHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDW 480

Query: 449 LRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA 484
           LRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
Sbjct: 481 LRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA 516


>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
           [Homo sapiens]
          Length = 463

 Score =  930 bits (2404), Expect = 0.0
 Identities = 456/457 (99%), Positives = 457/457 (100%)

Query: 28  EARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLT 87
           +ARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLT
Sbjct: 7   QARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLT 66

Query: 88  TYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRH 147
           TYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRH
Sbjct: 67  TYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRH 126

Query: 148 QGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRS 207
           QGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRS
Sbjct: 127 QGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRS 186

Query: 208 VFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDI 267
           VFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDI
Sbjct: 187 VFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDI 246

Query: 268 VGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLA 327
           VGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLA
Sbjct: 247 VGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLA 306

Query: 328 ETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAM 387
           ETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAM
Sbjct: 307 ETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAM 366

Query: 388 GNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARD 447
           GNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARD
Sbjct: 367 GNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARD 426

Query: 448 WLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA 484
           WLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
Sbjct: 427 WLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA 463


>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
           [Homo sapiens]
          Length = 441

 Score =  372 bits (955), Expect = e-103
 Identities = 191/449 (42%), Positives = 278/449 (61%), Gaps = 47/449 (10%)

Query: 39  ALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTD 98
           AL  LS  LL  Y K VRPV +W K TTV +D+ V+AIL+VD +NQ+L T +WY++ W D
Sbjct: 31  ALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWND 90

Query: 99  EFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQ 158
           EFL WN   FD I ++S+P  +IW PDI+INEFVD+ + P++PYVY+   G ++NYKP+Q
Sbjct: 91  EFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQ 150

Query: 159 VVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELL 218
           VV+ACSL+ Y FPFDVQNCSLTF S LHT++D++++  R PE ++ D+  F+N  EWELL
Sbjct: 151 VVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELL 210

Query: 219 GVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGE 278
            V   +      S+  +A+++F VV+RR PL YVVSLL+PSIFLM++D+  FYLPPN   
Sbjct: 211 SVSSTY-SILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRA 269

Query: 279 RVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHK 338
           R+ FK ++L+GY+VF + +S+ +P +   TPLIG +F +CMA LV+SLA++I +V+ +H 
Sbjct: 270 RIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHD 329

Query: 339 QD---LQQPVPAWLRHLVLERIAWLLCLREQSTSQRP---PATSQATKTDDCSAMGNHCS 392
           +     +QP                LCLR  + + RP   P   +A  T+  S  G H +
Sbjct: 330 EQRGGQEQP---------------FLCLRGDTDADRPRVEPRAQRAVVTES-SLYGEHLA 373

Query: 393 HMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVG 452
             G  ++                        +  +L SI  +L+ +D+  +   +WL + 
Sbjct: 374 QPGTLKE------------------------VWSQLQSISNYLQTQDQTDQQEAEWLVLL 409

Query: 453 SVLDKLLFHIYLLAVLAYSITLVMLWSIW 481
           S  D+LLF  YL  +  Y+ITL  LW++W
Sbjct: 410 SRFDRLLFQSYLFMLGIYTITLCSLWALW 438


>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
          Length = 471

 Score =  294 bits (752), Expect = 1e-79
 Identities = 169/433 (39%), Positives = 254/433 (58%), Gaps = 33/433 (7%)

Query: 52  RKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNI 111
           RK  RPV +   PT V+I   + AIL+V+E+  +L++++W    W + F+ WNPE+ + I
Sbjct: 66  RKPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGI 125

Query: 112 TKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFP 171
           TK+S+   ++W+PDI I E +DV K+P     Y+ ++G ++  KP++V + C+LDI+ FP
Sbjct: 126 TKMSMAAKNLWLPDIFIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFP 185

Query: 172 FDVQNCSLTFTSWLHTIQ----DINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREF 227
           FD QNC+LTF+S+L+T+     D+   +W + +   + R++    GEWELLG+     + 
Sbjct: 186 FDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITD---ASRNILQTHGEWELLGLSKATAKL 242

Query: 228 SMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLL 287
           S    N Y ++ FYV IRRRP  YV++LL+PS FL+ +D + FYLP  SG RV FKITLL
Sbjct: 243 S-RGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLL 301

Query: 288 LGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQ-QPVP 346
           LGY+VFL+++SD LP +  GTPLIGVYF +C++L+V SL ETIFI  L+H    Q  P+P
Sbjct: 302 LGYNVFLLMMSDLLPTS--GTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLP 359

Query: 347 AWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRD 406
            WL  L+L   +   C         P A  +  K       G   +H+ G     K P  
Sbjct: 360 RWLHSLLLHCNSPGRCC--------PTAPQKENK-----GPGLTPTHLPG----VKEPEV 402

Query: 407 RCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLA 466
                P P EA L   G  +   + R+   ++    E+   WL+    +D +LF +YLL 
Sbjct: 403 SAGQMPGPAEAELT--GGSEWTRAQREHEAQKQHSVEL---WLQFSHAMDAMLFRLYLLF 457

Query: 467 VLAYSITLVMLWS 479
           + +  IT++ LW+
Sbjct: 458 MASSIITVICLWN 470


>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
          Length = 447

 Score =  284 bits (726), Expect = 1e-76
 Identities = 161/433 (37%), Positives = 252/433 (58%), Gaps = 42/433 (9%)

Query: 52  RKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNI 111
           RK  RP  ++  PT V+I   + AIL VD + Q+LT+++W    W + F+ WNP++   I
Sbjct: 51  RKAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGI 110

Query: 112 TKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFP 171
            KL++  +++W+PDI I E +DV ++P+    YI  +G ++  KP++V + C+LDI+ FP
Sbjct: 111 NKLTVLAENLWLPDIFIVESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFP 170

Query: 172 FDVQNCSLTFTSWLHTIQDINISL----WRLPEKVKSDRSVFMNQGEWELLGVLPYFREF 227
           FD QNC+ TF+S+L+T+  + + +    W + +   + R V   QGEWELLG+     + 
Sbjct: 171 FDQQNCTFTFSSFLYTVDSMLLGMDKEVWEITD---TSRKVIQTQGEWELLGINKATPKM 227

Query: 228 SMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLL 287
           SM  +N Y ++ FYV IRRRP  Y+++LL+PS FL+ +D + FYLP  S  R  FKITLL
Sbjct: 228 SM-GNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLL 286

Query: 288 LGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQ-QPVP 346
           LGY+VFL++++D LPA+  GTPLI VYF +C++L+V+SL ET+FI  L+H    Q  P+P
Sbjct: 287 LGYNVFLLMMNDLLPAS--GTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMP 344

Query: 347 AWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRD 406
            WL  L+L   +   C         P A  +  K      +G   +H+ GP    K P +
Sbjct: 345 RWLHSLLLHCTSPGRCC--------PTAPQKGNK-----GLGLTLTHLPGP----KEPGE 387

Query: 407 RCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLA 466
                  PRE          E      +   + ++ E+   W++    +D LLF +YLL 
Sbjct: 388 LAGKKLGPRET---------EPDGGSGW--TKTQLMEL---WVQFSHAMDTLLFRLYLLF 433

Query: 467 VLAYSITLVMLWS 479
           + +  +T+++LW+
Sbjct: 434 MASSILTVIVLWN 446


>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
           sapiens]
          Length = 450

 Score =  231 bits (589), Expect = 1e-60
 Identities = 145/470 (30%), Positives = 234/470 (49%), Gaps = 43/470 (9%)

Query: 15  LLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVY 74
           LL  LLP      E R +        L+L   L  NY   +RPV D  +   V+++V + 
Sbjct: 13  LLLFLLPAECLGAEGRLA--------LKLFRDLFANYTSALRPVADTDQTLNVTLEVTLS 64

Query: 75  AILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDV 134
            I+++DE+NQVLT Y+W RQ WTD +L+W+P  +  +  + IP+  +W PDI++    D 
Sbjct: 65  QIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADA 124

Query: 135 GKSPNI-PYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINI 193
               +    V +RH G V+   P    ++C +D+  FPFD Q+C LTF SW H    +++
Sbjct: 125 QPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDV 184

Query: 194 SLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSME-SSNYYAEMKFYVVIRRRPLFYV 252
                P    +  + F+   EW +LG+    R  +    S  Y ++ F +++RRR   YV
Sbjct: 185 R----PRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYV 240

Query: 253 VSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIG 312
            +LLLP + + ++  + F+LP +SGE+VS  +T+LL  +VF +++++++P  A   PLIG
Sbjct: 241 CNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMP-PAESVPLIG 299

Query: 313 VYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQST---S 369
            Y++  M ++  S A TI I+ L +     +PVPAW R L+L  +A  LC+RE+      
Sbjct: 300 KYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQ 359

Query: 370 QRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVC---GLLQ 426
            RPP  S +                  PQ    SP     PP  P      +C    LL 
Sbjct: 360 SRPPELSPS------------------PQ----SPEGGAGPPAGPCHEPRCLCRQEALLH 397

Query: 427 ELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVM 476
            +++I          +    DW R+  V+D+    I+    L  S+ +++
Sbjct: 398 HVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLV 447


>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
          Length = 494

 Score =  219 bits (557), Expect = 6e-57
 Identities = 125/447 (27%), Positives = 230/447 (51%), Gaps = 32/447 (7%)

Query: 42  RLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFL 101
           RL   L ++Y + +RPV +   P TV  +V +  + NVDE NQ++ T +W R  W D  L
Sbjct: 36  RLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKL 95

Query: 102 QWNPEDFDNITKLSIPTDSIWVPDIL-----INEFVDVGKSPNIPYVYIRHQGEVQNYKP 156
           +W+P ++D I  L +P D IW PDI+     + +F   GK+  +    +++ G +    P
Sbjct: 96  RWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKAL----LKYNGMITWTPP 151

Query: 157 LQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWE 216
               ++C +DI  FPFD QNCSL F SW +   +I++ +  +  KV  D + F    EWE
Sbjct: 152 AIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLI--IGSKV--DMNDFWENSEWE 207

Query: 217 LLGVLPYFREFSMES-SNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPN 275
           ++    Y  +         Y ++ +   IRR P+FY ++L++P +F+  + ++ FYLP +
Sbjct: 208 IIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSD 267

Query: 276 SGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRL 335
            GE+V+  I++LL  +VFL+++++T+P+T++  PL+G Y +  M  + +S+  T+F++ +
Sbjct: 268 CGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNI 327

Query: 336 VHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQR-------PPATSQATKTDDCSAMG 388
            ++      +P W++ + L+ +  +L +R      R       P   ++       ++ G
Sbjct: 328 HYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLARRPAKGKLASHG 387

Query: 389 -----NHCSHMGGPQDFEKSPRDRCSPPP-----PPREASLAVCGLLQELSSIRQFLEKR 438
                  C H     +   S R R S  P        E S  V  ++  +  I + ++  
Sbjct: 388 EPRHLKECFHCHKSNELATSKR-RLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSH 446

Query: 439 DEIREVARDWLRVGSVLDKLLFHIYLL 465
           +E +EV  DW  V  V+D++   ++++
Sbjct: 447 NETKEVEDDWKYVAMVVDRVFLWVFII 473


>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
           [Homo sapiens]
          Length = 458

 Score =  216 bits (550), Expect = 4e-56
 Identities = 131/462 (28%), Positives = 235/462 (50%), Gaps = 27/462 (5%)

Query: 15  LLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVY 74
           L+ L +P+    G    + N    ALLR   +L   Y+K VRPV        V   + + 
Sbjct: 9   LIVLGIPSSATTGFNSIAEN--EDALLR---HLFQGYQKWVRPVLHSNDTIKVYFGLKIS 63

Query: 75  AILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDV 134
            +++VDEKNQ++TT +W +Q WTD  L+WNP+D+  I  + +P++S+W+PDI++ E  D 
Sbjct: 64  QLVDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADG 123

Query: 135 G-KSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINI 193
             +   +  V ++  G V    P    ++C++D+  FPFD QNCS+ F SW  T     +
Sbjct: 124 RFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSW--TYDGTMV 181

Query: 194 SLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVV 253
            L  + E V  DR  F + GEWE+L      +    +    Y  + +  V+RR PLFY +
Sbjct: 182 DLILINENV--DRKDFFDNGEWEILNA-KGMKGNRRDGVYSYPFITYSFVLRRLPLFYTL 238

Query: 254 SLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGV 313
            L++P + L  + ++ FYLP + GE++S   ++L+  +VFL+++ + +P+++   PLIG 
Sbjct: 239 FLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGE 298

Query: 314 YFVVCMALLVISLAETIFIVRLVHK-QDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRP 372
           Y +  M  + +S+  T+F++ + H+      P+  W++ L L+++  LLC+++       
Sbjct: 299 YLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSS 358

Query: 373 PATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIR 432
           P   ++        +             EK  + + S       A L        +  I 
Sbjct: 359 PEKEESQPVVKGKVL-------------EKKKQKQLSDGEKVLVAFLEKAA--DSIRYIS 403

Query: 433 QFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITL 474
           + ++K   I +V +DW  V  VLD++   ++L+  +  S+ +
Sbjct: 404 RHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSVTGSVLI 445


>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
           [Homo sapiens]
          Length = 479

 Score =  214 bits (544), Expect = 2e-55
 Identities = 131/449 (29%), Positives = 225/449 (50%), Gaps = 21/449 (4%)

Query: 42  RLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFL 101
           +L + L  +Y   +RPV D  K   V++ + +  I ++DE+NQ+LT Y+W RQ W D +L
Sbjct: 33  KLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYL 92

Query: 102 QWNPEDFDNITKLSIPTDSIWVPDI-LINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVV 160
            W+ + +D +  + IP+D +W PDI L N+  D    P    V +R+ G +    P    
Sbjct: 93  TWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITK 152

Query: 161 TACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGV 220
           ++C +D+  FPFD Q C+LTF SW +    ++I           D S F+   EWE+ G+
Sbjct: 153 SSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDI----FNALDSGDLSDFIEDVEWEVHGM 208

Query: 221 LPYFREFSME-SSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGER 279
                  S    S  Y ++ F ++++RR  FY+V+LL+P + +  +  + FYLP  SGE+
Sbjct: 209 PAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEK 268

Query: 280 VSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQ 339
           VS  +T+LL  +VF ++V++ +PA+    PLIG Y++  MAL+  S A TI ++ +    
Sbjct: 269 VSLGVTILLAMTVFQLMVAEIMPASE-NVPLIGKYYIATMALITASTALTIMVMNIHFCG 327

Query: 340 DLQQPVPAWLRHLVLERIAWLL--------CLREQSTSQRPPATSQATKTDDCSAMGNHC 391
              +PVP W R ++L+ ++ +L        CL    + +R   T   +K  + +      
Sbjct: 328 AEARPVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTKVYSKLPESNLKAARN 387

Query: 392 SHMGGPQDFEKS-PRDRCSPPPPPREASLAVCG----LLQELSSIRQFLEKRDEIREVAR 446
             +   +D  K    D       P+EA  + C     L + +  I + L+          
Sbjct: 388 KDLSRKKDMNKRLKNDLGCQGKNPQEAE-SYCAQYKVLTRNIEYIAKCLKDHKATNSKGS 446

Query: 447 DWLRVGSVLDKLLFHIYLLAVLAYSITLV 475
           +W +V  V+D+    I+ + V   +I ++
Sbjct: 447 EWKKVAKVIDRFFMWIFFIMVFVMTILII 475


>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
           precursor [Homo sapiens]
          Length = 502

 Score =  213 bits (543), Expect = 2e-55
 Identities = 124/458 (27%), Positives = 233/458 (50%), Gaps = 32/458 (6%)

Query: 42  RLSDYLL--TNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDE 99
           RL ++LL  + Y K +RP  +  +  TV + V +  +++V E+ Q++TT +W  Q W D 
Sbjct: 31  RLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDY 90

Query: 100 FLQWNPEDFDNITKLSIPTDSIWVPDILINEFVD-VGKSPNIPYVYIRHQGEVQNYKPLQ 158
            L W PE+FDN+ K+ +P+  IW+PD+++    D + +        + + G +    P  
Sbjct: 91  RLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAI 150

Query: 159 VVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELL 218
             +AC +++ +FPFD QNC++ F SW +   +I++ L    +   +    F   GEW+++
Sbjct: 151 YKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVL----KSEVASLDDFTPSGEWDIV 206

Query: 219 GVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGE 278
             LP  R  + + S Y  ++ +  +IRR+PLFY ++L++P + +  + I+ FYLP + GE
Sbjct: 207 A-LPGRRNENPDDSTY-VDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGE 264

Query: 279 RVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHK 338
           +++  I++LL  +VFL+++S  +P T++  PL+G Y +  M L+  S+  ++ ++ + H+
Sbjct: 265 KMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHR 324

Query: 339 QDLQQPVPAWLRHLVLERIAWLL--------CLREQSTSQRPPAT---------SQATKT 381
                 +  W++ + LE++  LL        C R++   +R              +A   
Sbjct: 325 SPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGA 384

Query: 382 DDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIR---QFLEKR 438
           D C+   N  S  G    F   P        P R      CGL + +  +R     +   
Sbjct: 385 DSCTCFVNRASVQGLAGAFGAEPAPVAG---PGRSGEPCGCGLREAVDGVRFIADHMRSE 441

Query: 439 DEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVM 476
           D+ + V+ DW  V  V+D+L   I++   +  +I + +
Sbjct: 442 DDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFL 479


>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
          Length = 468

 Score =  213 bits (541), Expect = 4e-55
 Identities = 121/429 (28%), Positives = 213/429 (49%), Gaps = 37/429 (8%)

Query: 47  LLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPE 106
           L  +Y + VRPV        +   + +  +++VDEKNQ++TT +W +Q W D  L+WNP+
Sbjct: 54  LFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPD 113

Query: 107 DFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLD 166
           D+  I  + +P+DS+W PDI++ +  D           IR+ G V    P    ++C++D
Sbjct: 114 DYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTID 173

Query: 167 IYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFRE 226
           +  FPFD+QNCS+ F SW +    ++I L    E    D+  F + GEWE++      + 
Sbjct: 174 VTFFPFDLQNCSMKFGSWTYDGSQVDIIL----EDQDVDKRDFFDNGEWEIVSATGS-KG 228

Query: 227 FSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITL 286
              +S  +Y  + +  VI+R PLFY + L++P I L  + ++ FYLP N GE++    ++
Sbjct: 229 NRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSV 288

Query: 287 LLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVP 346
           L+  +VFL+++ + +P+++   PLIG Y V  M  + +S+  T+F + + H+        
Sbjct: 289 LVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAM 348

Query: 347 AWL-RHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPR 405
           A L R + L  +  LLC+R                           SH+    D   + +
Sbjct: 349 APLVRKIFLHTLPKLLCMR---------------------------SHV----DRYFTQK 377

Query: 406 DRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLL 465
           +       P+ +   +   L  +  I + + K +++REV  DW  +  VLD++    +L 
Sbjct: 378 EETESGSGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLF 437

Query: 466 AVLAYSITL 474
             +  S+ L
Sbjct: 438 VSIVGSLGL 446


>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
           precursor [Homo sapiens]
          Length = 627

 Score =  212 bits (539), Expect = 7e-55
 Identities = 114/356 (32%), Positives = 197/356 (55%), Gaps = 10/356 (2%)

Query: 18  LLLPTLLAQG----EARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIV 73
           LL P LL  G     A     T   A  RL   L + Y K  RPV +      V   + +
Sbjct: 11  LLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSI 70

Query: 74  YAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVD 133
             +++VDEKNQ++TT +W +Q W D  L+W+P D++N+T + IP++ IW PDI++    D
Sbjct: 71  AQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNAD 130

Query: 134 VGKS-PNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDIN 192
              +  ++   ++ H G VQ   P    ++CS+D+  FPFD QNC++ F SW  T     
Sbjct: 131 GDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSW--TYDKAK 188

Query: 193 ISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMES-SNYYAEMKFYVVIRRRPLFY 251
           I L  +  +V  D+  F   GEW ++  +  +     E  +  Y ++ +  VIRR PLFY
Sbjct: 189 IDLVNMHSRV--DQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFY 246

Query: 252 VVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLI 311
            ++L++P + +  + ++ FYLP   GE+++  I++LL  +VFL+++++ +P+T++  PLI
Sbjct: 247 TINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLI 306

Query: 312 GVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQS 367
           G Y +  M  + +S+  T+F++ + H+      +P W+R + L+ +  LL ++  S
Sbjct: 307 GEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPS 362



 Score = 31.2 bits (69), Expect = 2.2
 Identities = 16/66 (24%), Positives = 31/66 (46%)

Query: 411 PPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAY 470
           PPP    S A+   ++ +  I   L+  D    V  DW  V  V+D++   ++++  L  
Sbjct: 554 PPPHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLG 613

Query: 471 SITLVM 476
           ++ L +
Sbjct: 614 TVGLFL 619


>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
           sapiens]
          Length = 502

 Score =  208 bits (530), Expect = 8e-54
 Identities = 144/499 (28%), Positives = 235/499 (47%), Gaps = 57/499 (11%)

Query: 14  ALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIV 73
           AL A LL   L QGE +R          +L   L+ NY    RPV +  +P TV   + +
Sbjct: 11  ALAASLLHVSL-QGEFQR----------KLYKELVKNYNPLERPVANDSQPLTVYFSLSL 59

Query: 74  YAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVD 133
             I++VDEKNQVLTT IW +  WTD +LQWN  ++  +  +  P   IW PDIL+    D
Sbjct: 60  LQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSAD 119

Query: 134 VGKSPNI-PYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDIN 192
                     V +   G  Q   P    ++C +D+  FPFDVQ+C L F SW +    ++
Sbjct: 120 ERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLD 179

Query: 193 ISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNY-YAEMKFYVVIRRRPLFY 251
           + +       ++D S ++  GEW+L+G+     E   E     Y ++ F V +RRR L+Y
Sbjct: 180 LQMQ------EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYY 233

Query: 252 VVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLI 311
            ++LL+P + +  + ++ F LP +SGE++S  IT+LL  +VF+++V++ +PAT+   PLI
Sbjct: 234 GLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLI 293

Query: 312 GVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQR 371
             YF   M ++ +S+  T+ +++  H       +P W R ++L   AW L ++     + 
Sbjct: 294 AQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKV 353

Query: 372 PPATSQATKTDDCSAM------------------------GNHCSHMGGPQDFEKSPRDR 407
            PA     +    +++                        G HC  +  P       R  
Sbjct: 354 RPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHC--VPTPDSGVVCGRMA 411

Query: 408 CSPP----------PPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDK 457
           CSP           PP  +  LA   +L+E+  I      +DE   V  +W     V+D+
Sbjct: 412 CSPTHDEHLLHGGQPPEGDPDLAK--ILEEVRYIANRFRCQDESEAVCSEWKFAACVVDR 469

Query: 458 LLFHIYLLAVLAYSITLVM 476
           L    + +  +  +I ++M
Sbjct: 470 LCLMAFSVFTIICTIGILM 488


>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
           (neuronal) [Homo sapiens]
          Length = 529

 Score =  206 bits (524), Expect = 4e-53
 Identities = 109/347 (31%), Positives = 190/347 (54%), Gaps = 13/347 (3%)

Query: 21  PTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVD 80
           PT L QG +            RL  +L   Y +  RPV +      V   + +  +++VD
Sbjct: 46  PTALPQGGSHTETED------RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVD 99

Query: 81  EKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKS-PN 139
           EKNQ++TT +W +Q W+D  L+WNP DF NIT L +P++ IW+PDI++    D   +  +
Sbjct: 100 EKNQMMTTNVWLKQEWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTH 159

Query: 140 IPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLP 199
           +   ++   G V    P    ++CS+D+  FPFD QNC + F SW  T     I L ++ 
Sbjct: 160 MTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSW--TYDKAKIDLEQME 217

Query: 200 EKVKSDRSVFMNQGEWELLGVLPYFREFSMES-SNYYAEMKFYVVIRRRPLFYVVSLLLP 258
           + V  D   +   GEW ++     +     +  +  Y ++ +  VIRR PLFY ++L++P
Sbjct: 218 QTV--DLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIP 275

Query: 259 SIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVC 318
            + +  + ++ FYLP + GE+++  I++LL  +VFL+++++ +P+T++  PLIG Y +  
Sbjct: 276 CLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFT 335

Query: 319 MALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERI-AWLLCLR 364
           M  + +S+  T+F++ + H+      +P W+R  +L  +  WLL  R
Sbjct: 336 MIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNR 382


>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
          Length = 498

 Score =  204 bits (519), Expect = 1e-52
 Identities = 130/486 (26%), Positives = 238/486 (48%), Gaps = 35/486 (7%)

Query: 14  ALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLL--TNYRKGVRPVRDWRKPTTVSIDV 71
           +L+   L  L  +G  R +      A  +L D LL  T Y   +RP     +  ++ + +
Sbjct: 6   SLVLFFLVALCGRGNCRVAN-----AEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL 60

Query: 72  IVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEF 131
            +  +++V+E+ Q++TT +W +Q WTD  L WN   ++ +  L IP   IW+PDI++   
Sbjct: 61  SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN 120

Query: 132 VDVGKSPNI-PYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQD 190
            D     ++   + +R  G V    P    +AC +++  FPFD QNC+L F SW +   +
Sbjct: 121 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE 180

Query: 191 INISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLF 250
           I++ L   P     D   F   GEW+++  LP  R  + +  +Y  ++ +  +I+R+PLF
Sbjct: 181 IDMVLMT-PTASMDD---FTPSGEWDIVA-LPGRRTVNPQDPSY-VDVTYDFIIKRKPLF 234

Query: 251 YVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPL 310
           Y ++L++P +   ++ I+ FYLP + GE+++  I++LL  + FL+++S  +P T++  PL
Sbjct: 235 YTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPL 294

Query: 311 IGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQ 370
           IG Y +  M L+  S+  ++ ++ + H+      +  W++   L ++   L ++      
Sbjct: 295 IGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDS 354

Query: 371 R-----PPATS-------QATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREAS 418
                 PP+ S        AT T   +  GN    +       KSP    +P   PR+  
Sbjct: 355 SPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAG-STPVAIPRDFW 413

Query: 419 LAVCG--------LLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAY 470
           L   G         L+ +S I Q ++  DE + V  DW  V  V+D+L   +++   +  
Sbjct: 414 LRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLG 473

Query: 471 SITLVM 476
           ++ L +
Sbjct: 474 TVGLFL 479


>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
           precursor [Homo sapiens]
          Length = 457

 Score =  202 bits (515), Expect = 4e-52
 Identities = 126/461 (27%), Positives = 231/461 (50%), Gaps = 38/461 (8%)

Query: 18  LLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAIL 77
           LLL +L + G    S + TR     L   L  +Y   VRPV D R+   V++ + +  ++
Sbjct: 7   LLLFSLCSAGLVLGSEHETR-----LVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLI 61

Query: 78  NVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKS 137
           NVDE NQ++TT +  +Q W D  L+WNP+D+  + K+ IP++ IW PD+++    D G  
Sbjct: 62  NVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNAD-GDF 120

Query: 138 PNIPY--VYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISL 195
             + +  V +++ G +    P    + C + + +FPFD QNCS+   +W +    + I+ 
Sbjct: 121 AIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAIN- 179

Query: 196 WRLPEKVKSDRSVFMNQGEWELLGVLPYFRE--FSMESSNYYAEMKFYVVIRRRPLFYVV 253
              PE  + D S FM  GEW +     +     +S      Y ++ ++ V++R PL+++V
Sbjct: 180 ---PESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIV 236

Query: 254 SLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGV 313
           ++++P +    +  + FYLP +SGE+++  I++LL  +VFL+++ + +P+T+   PLIG 
Sbjct: 237 NVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGK 296

Query: 314 YFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPP 373
           Y +  M  ++ S+  T+ ++   H+      +P W+R + ++ I  ++     ST +RP 
Sbjct: 297 YMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFF---STMKRPS 353

Query: 374 ATSQATK--TDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASL----AVCGLLQE 427
              Q  K  T+D               D    P     PPP    + L     V   ++ 
Sbjct: 354 REKQDKKIFTEDIDI-----------SDISGKP----GPPPMGFHSPLIKHPEVKSAIEG 398

Query: 428 LSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVL 468
           +  I + ++   E    A +W  V  V+D +L  +++L  +
Sbjct: 399 IKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCI 439


>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score =  202 bits (513), Expect = 7e-52
 Identities = 122/483 (25%), Positives = 234/483 (48%), Gaps = 40/483 (8%)

Query: 15  LLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVY 74
           LL LLL +LL    A  + +       RL + L  +Y + +RPV +   P  +  +V + 
Sbjct: 17  LLLLLLLSLLPVARASEAEH-------RLFERLFEDYNEIIRPVANVSDPVIIHFEVSMS 69

Query: 75  AILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILI-NEFVD 133
            ++ VDE NQ++ T +W +Q W D  L+WNP D+     + +P   IW PDI++ N  V 
Sbjct: 70  QLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVG 129

Query: 134 VGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINI 193
             +  +     +++ GEV    P    ++C +D+  FPFD QNC++ F SW +    I++
Sbjct: 130 DFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDL 189

Query: 194 SLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMES-SNYYAEMKFYVVIRRRPLFYV 252
            L      +K     +   GEW ++    Y  +         Y ++ + + IRR PLFY 
Sbjct: 190 VLIGSSMNLKD----YWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYT 245

Query: 253 VSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIG 312
           ++L++P + +  + ++ FYLP + GE+V+  I++LL  +VFL+++++T+P+T++  PLIG
Sbjct: 246 INLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIG 305

Query: 313 VYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCL----REQST 368
            Y +  M  + +S+  T+F++ + ++      +P+W++ + L  +  ++ +      +  
Sbjct: 306 EYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGN 365

Query: 369 SQRP-PATSQATKTDDC----------------SAMGNHCSHMG-GPQDFEKSPRDRCSP 410
           +Q+P P         +C                  M  +C H      +F  +     S 
Sbjct: 366 AQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSS 425

Query: 411 PPPPREASLAVCG-----LLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLL 465
                  SL+         +Q +  I + ++ ++E +E+  DW  V  V+D++   ++ L
Sbjct: 426 ESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTL 485

Query: 466 AVL 468
             +
Sbjct: 486 VCI 488


>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
           precursor [Homo sapiens]
          Length = 482

 Score =  189 bits (479), Expect = 6e-48
 Identities = 126/486 (25%), Positives = 231/486 (47%), Gaps = 63/486 (12%)

Query: 18  LLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAIL 77
           LLL +L + G    S + TR     L   L  +Y   VRPV D R+   V++ + +  ++
Sbjct: 7   LLLFSLCSAGLVLGSEHETR-----LVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLI 61

Query: 78  NVDEKNQVLTTYIWYRQ-------------------------YWTDEFLQWNPEDFDNIT 112
           NVDE NQ++TT +  +Q                          W D  L+WNP+D+  + 
Sbjct: 62  NVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVK 121

Query: 113 KLSIPTDSIWVPDILINEFVDVGKSPNIPY--VYIRHQGEVQNYKPLQVVTACSLDIYNF 170
           K+ IP++ IW PD+++    D G    + +  V +++ G +    P    + C + + +F
Sbjct: 122 KIHIPSEKIWRPDLVLYNNAD-GDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF 180

Query: 171 PFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFRE--FS 228
           PFD QNCS+   +W +    + I+    PE  + D S FM  GEW +     +     +S
Sbjct: 181 PFDEQNCSMKLGTWTYDGSVVAIN----PESDQPDLSNFMESGEWVIKESRGWKHSVTYS 236

Query: 229 MESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLL 288
                 Y ++ ++ V++R PL+++V++++P +    +  + FYLP +SGE+++  I++LL
Sbjct: 237 CCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLL 296

Query: 289 GYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAW 348
             +VFL+++ + +P+T+   PLIG Y +  M  ++ S+  T+ ++   H+      +P W
Sbjct: 297 SLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNW 356

Query: 349 LRHLVLERIAWLLCLREQSTSQRPPATSQATK--TDDCSAMGNHCSHMGGPQDFEKSPRD 406
           +R + ++ I  ++     ST +RP    Q  K  T+D               D    P  
Sbjct: 357 VRKVFIDTIPNIMFF---STMKRPSREKQDKKIFTEDIDI-----------SDISGKP-- 400

Query: 407 RCSPPPPPREASL----AVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHI 462
              PPP    + L     V   ++ +  I + ++   E    A +W  V  V+D +L  +
Sbjct: 401 --GPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGV 458

Query: 463 YLLAVL 468
           ++L  +
Sbjct: 459 FMLVCI 464


>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
           precursor [Homo sapiens]
          Length = 501

 Score =  186 bits (473), Expect = 3e-47
 Identities = 115/454 (25%), Positives = 221/454 (48%), Gaps = 35/454 (7%)

Query: 42  RLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFL 101
           RL + L + Y   VRP R+      VS+ +I+  +++++EK++ ++T ++    WTD  L
Sbjct: 29  RLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDYRL 88

Query: 102 QWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPY-VYIRHQGEVQNYKPLQVV 160
            W+P + D I  L I  +S+W+PD+++    D      +   V +   G V+   P    
Sbjct: 89  SWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGIYR 148

Query: 161 TACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPE-----KVKSDRSVFMNQGEW 215
           ++CS+ +  FPFD QNC++ F+S+ +   ++++     P+     ++      F+  G+W
Sbjct: 149 SSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQW 208

Query: 216 ELLGVLPYFREFSMES----SNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFY 271
           E++       +   +          E+ FY++IRR+PLFY+V+++ P I + ++ I  FY
Sbjct: 209 EIIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFY 268

Query: 272 LPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIF 331
           LPP++GE++   I  LL  +VFL++++D +P T++  P+I  Y +  M L+  S+  ++ 
Sbjct: 269 LPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVV 328

Query: 332 IVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHC 391
           ++ L H+      +P W+R + + ++   L L+        P      +   CS+ G+  
Sbjct: 329 VLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLKRPK-----PERDLMPEPPHCSSPGSGW 383

Query: 392 SHMGGPQDFEKSPRDRCSPPPPPREASLA-------------VCGLLQEL-------SSI 431
                     K P D   P P   +  L+                LL EL       S I
Sbjct: 384 GRGTDEYFIRKPPSDFLFPKPNRFQPELSAPDLRRFIDGPNRAVALLPELREVVSSISYI 443

Query: 432 RQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLL 465
            + L+++++   +  DW  V  V+D+L    +++
Sbjct: 444 ARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFII 477


>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  176 bits (446), Expect = 4e-44
 Identities = 104/328 (31%), Positives = 179/328 (54%), Gaps = 23/328 (7%)

Query: 51  YRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDN 110
           Y K +RPV    +   V++ + +  ++++ E  + LTT +W    WTD  L+WN E+F N
Sbjct: 38  YNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGN 97

Query: 111 ITKLSIPTDSIWVPDILINEFVDVGKSPNIPY---VYIRHQGEVQNYKPLQVVTACSLDI 167
           I+ L +P D +W+P+I++    D   S  I Y   V + H G V    P    ++C + +
Sbjct: 98  ISVLRLPPDMVWLPEIVLENNND--GSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISV 155

Query: 168 YNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKS--------DRSVFMNQGEWELL- 218
             FPFD QNCSL F+S  +T ++I +SL +  ++ ++        D   F   GEWE++ 
Sbjct: 156 TYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVH 215

Query: 219 -----GVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLP 273
                 V P     +   S    ++ FY++IRR+PLFY++++L+P + +  M  + FYLP
Sbjct: 216 RPARVNVDPR----APLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLP 271

Query: 274 PNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIV 333
            +SGE+ S  I++LL  SVFL+++S  LPAT++  PLIG + +  M L+ + +   + ++
Sbjct: 272 ADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVL 331

Query: 334 RLVHKQDLQQPVPAWLRHLVLERIAWLL 361
            +  +      +   ++ L LE +  LL
Sbjct: 332 NIHFRTPSTHVLSEGVKKLFLETLPELL 359


>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
           precursor [Homo sapiens]
          Length = 493

 Score =  166 bits (419), Expect = 6e-41
 Identities = 112/470 (23%), Positives = 216/470 (45%), Gaps = 46/470 (9%)

Query: 18  LLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAIL 77
           LLL  LL +G  +          LRL  +L  NY  G RPVR+     T+S+ V +  ++
Sbjct: 9   LLLLGLLGRGVGKNEE-------LRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLI 61

Query: 78  NVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVD---- 133
           +++EK + LTT +W    W D  L ++ +DF  I  L +P++ +W+P+I++   +D    
Sbjct: 62  SLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFG 121

Query: 134 VGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINI 193
           V    N   V +   G V    P    + C++++  FPFD QNCSL F S  +  +++  
Sbjct: 122 VAYDAN---VLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEF 178

Query: 194 SL-----WRLPEKVKSDRSVFMNQGEWEL---LGVLPYFREFSMESSNYYAEMKFYVVIR 245
           +       +   K+  D   +   GEW +    GV+      + +      ++ + ++IR
Sbjct: 179 TFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPG-ETDVIYSLIIR 237

Query: 246 RRPLFYVVSLLLPSIFLMVMDIVGFYLPPNS-GERVSFKITLLLGYSVFLIIVSDTLPAT 304
           R+PLFYV+++++P + +  + ++ ++LP  + G++ +  I +LL  +VFL +++  +P T
Sbjct: 238 RKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPET 297

Query: 305 AIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLR 364
           ++  PL+G + +  M +  + +   + ++ +  +      +   LRH++LE +  LL   
Sbjct: 298 SLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLL--- 354

Query: 365 EQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGL 424
              +   P A   A+     S++G     +   +   K PR                   
Sbjct: 355 --GSPPPPEAPRAASPPRRASSVG---LLLRAEELILKKPRSELVFEGQRHRQGTWTAAF 409

Query: 425 LQELSS--------------IRQFLEKRDEIREVARDWLRVGSVLDKLLF 460
            Q L +              + +    ++   E   DW+R+G+ LD + F
Sbjct: 410 CQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICF 459


>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  146 bits (368), Expect = 5e-35
 Identities = 97/372 (26%), Positives = 181/372 (48%), Gaps = 15/372 (4%)

Query: 18  LLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAIL 77
           LLL  LLA     + RN       RL   L+ NY   +RP         VS+ + +  ++
Sbjct: 8   LLLLLLLAVCLGAQGRNQEE----RLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLI 63

Query: 78  NVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVD-VGK 136
           +++E+ + LTT +W    W D  L+W+P D++ +  L +P+  +W PDI++   VD V +
Sbjct: 64  SLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFE 123

Query: 137 SPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISL- 195
                 V +   G +    P    +ACS+ +  FPFD QNCSL F S  ++  +I++ L 
Sbjct: 124 VALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLS 183

Query: 196 ---WRLPEKVKSDRSVFMNQGEWEL--LGVLPYFREFSMESSNYYAEMKFYVVIRRRPLF 250
               +  E +  D   F   GEW +            +      + ++ FY++I+R+PLF
Sbjct: 184 QEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLF 243

Query: 251 YVVSLLLPSIFLMVMDIVGFYLPPNS-GERVSFKITLLLGYSVFLIIVSDTLPATAIGTP 309
           YV++++ P + +  + I+  +LP  + G++ +  I +LL  +VFL +V+  +P T+   P
Sbjct: 244 YVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVP 303

Query: 310 LIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTS 369
           LI  Y    + + ++ +   + ++ +  +      +   +R + L  +  LL +  +  +
Sbjct: 304 LISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMHVRPLA 363

Query: 370 QRPPATSQATKT 381
              PA  Q T++
Sbjct: 364 ---PAAVQDTQS 372


>gi|223468705 5-hydroxytryptamine receptor 3 subunit D isoform 1
           [Homo sapiens]
          Length = 404

 Score =  144 bits (363), Expect = 2e-34
 Identities = 128/450 (28%), Positives = 200/450 (44%), Gaps = 78/450 (17%)

Query: 59  RDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPT 118
           R W       +  I++ +L  D   Q++T+++W           WNP++   I K  + T
Sbjct: 3   RGWFHGKGFLLGFILHLLLQ-DSHLQLVTSFLWLNM--------WNPDECGGIKKSGMAT 53

Query: 119 DSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCS 178
           +++W+ D+ I E VD              Q        + +V A S  I    +   + S
Sbjct: 54  ENLWLSDVFIEESVD--------------QTPAGLMASMSIVKATSNTISQCGW---SAS 96

Query: 179 LTFTSWLHTIQDIN------------ISLWRLPEKVKS--DRSVFMNQGEWELLGVLPYF 224
             +T  +    D                 WR   +      R+ F  + EW LLG+    
Sbjct: 97  ANWTPSISPSMDRGERSPSALSPTQVTRAWRRMSRSFQIHHRTSFRTRREWVLLGIQKRT 156

Query: 225 REFSMESSNYYAEMKFYVVIRRR--PLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSF 282
            + ++ ++N Y +  F+V IRRR  P  YVV+ L+PS  L+ +D + FYLP  SG    F
Sbjct: 157 IKVTV-ATNQYEQAIFHVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPF 215

Query: 283 KITLLLGYSVFLIIVSDTLPATAIGTPLI------------GVYFVVCMALLVISLAETI 330
           K+T+LLGYSVFL++++D LPAT+  +               GVYF +C++L+V SL ETI
Sbjct: 216 KMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETI 275

Query: 331 FIVRLVHKQDLQQ-PVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGN 389
           FI  L+H    Q  P+P WL  L+L       C         P A  +  K       G 
Sbjct: 276 FITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCC--------PTAPQKGNK-----GPGL 322

Query: 390 HCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWL 449
             +H+ G     K P       P P EA L   G  +   + R+   ++    E+   W+
Sbjct: 323 TPTHLPG----VKEPEVSAGQMPGPGEAELT--GGSEWTRAQREHEAQKQHSVEL---WV 373

Query: 450 RVGSVLDKLLFHIYLLAVLAYSITLVMLWS 479
           +    +D LLF +YLL + +  IT++ LW+
Sbjct: 374 QFSHAMDALLFRLYLLFMASSIITVICLWN 403


>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
          Length = 412

 Score =  139 bits (351), Expect = 4e-33
 Identities = 96/369 (26%), Positives = 171/369 (46%), Gaps = 45/369 (12%)

Query: 143 VYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKV 202
           V +   G  Q   P    ++C +D+  FPFDVQ+C L F SW +    +++ +       
Sbjct: 40  VLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQ------ 93

Query: 203 KSDRSVFMNQGEWELLGVLPYFREFSMESSNY-YAEMKFYVVIRRRPLFYVVSLLLPSIF 261
           ++D S ++  GEW+L+G+     E   E     Y ++ F V +RRR L+Y ++LL+P + 
Sbjct: 94  EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVL 153

Query: 262 LMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMAL 321
           +  + ++ F LP +SGE++S  IT+LL  +VF+++V++ +PAT+   PLI  YF   M +
Sbjct: 154 ISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMII 213

Query: 322 LVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKT 381
           + +S+  T+ +++  H       +P W R ++L   AW L ++     +  PA     + 
Sbjct: 214 VGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRR 273

Query: 382 DDCSAM------------------------GNHCSHMGGPQDFEKSPRDRCSPP------ 411
              +++                        G HC  +  P       R  CSP       
Sbjct: 274 CSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHC--VPTPDSGVVCGRMACSPTHDEHLL 331

Query: 412 ----PPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAV 467
               PP  +  LA   +L+E+  I      +DE   V  +W     V+D+L    + +  
Sbjct: 332 HGGQPPEGDPDLAK--ILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFT 389

Query: 468 LAYSITLVM 476
           +  +I ++M
Sbjct: 390 IICTIGILM 398


>gi|47519877 5-hydroxytryptamine receptor 3 subunit D isoform 2
           [Homo sapiens]
          Length = 279

 Score =  117 bits (292), Expect = 3e-26
 Identities = 88/253 (34%), Positives = 126/253 (49%), Gaps = 37/253 (14%)

Query: 242 VVIRRR--PLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSD 299
           V IRRR  P  YVV+ L+PS  L+ +D + FYLP  SG    FK+T+LLGYSVFL++++D
Sbjct: 48  VAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMND 107

Query: 300 TLPATAIGTPLI------------GVYFVVCMALLVISLAETIFIVRLVHKQDLQQ-PVP 346
            LPAT+  +               GVYF +C++L+V SL ETIFI  L+H    Q  P+P
Sbjct: 108 LLPATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLP 167

Query: 347 AWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRD 406
            WL  L+L       C         P A  +  K       G   +H+ G     K P  
Sbjct: 168 RWLHSLLLHCTGQGRCC--------PTAPQKGNK-----GPGLTPTHLPG----VKEPEV 210

Query: 407 RCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLA 466
                P P EA L   G  +   + R+   ++    E+   W++    +D LLF +YLL 
Sbjct: 211 SAGQMPGPGEAELT--GGSEWTRAQREHEAQKQHSVEL---WVQFSHAMDALLFRLYLLF 265

Query: 467 VLAYSITLVMLWS 479
           + +  IT++ LW+
Sbjct: 266 MASSIITVICLWN 278


>gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
          Length = 321

 Score =  113 bits (283), Expect = 3e-25
 Identities = 79/309 (25%), Positives = 143/309 (46%), Gaps = 39/309 (12%)

Query: 203 KSDRSVFMNQGEWELLGVLPYFREFSMESSNY-YAEMKFYVVIRRRPLFYVVSLLLPSIF 261
           ++D S ++  GEW+L+G+     E   E     Y ++ F V +RRR L+Y ++LL+P + 
Sbjct: 3   EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVL 62

Query: 262 LMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMAL 321
           +  + ++ F LP +SGE++S  IT+LL  +VF+++V++ +PAT+   PLI  YF   M +
Sbjct: 63  ISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMII 122

Query: 322 LVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKT 381
           + +S+  T+ +++  H       +P W R ++L   AW L ++     +  PA     + 
Sbjct: 123 VGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRR 182

Query: 382 DDCSAM------------------------GNHCSHMGGPQDFEKSPRDRCSPP------ 411
              +++                        G HC  +  P       R  CSP       
Sbjct: 183 CSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHC--VPTPDSGVVCGRMACSPTHDEHLL 240

Query: 412 ----PPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAV 467
               PP  +  LA   +L+E+  I      +DE   V  +W     V+D+L    + +  
Sbjct: 241 HGGQPPEGDPDLAK--ILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFT 298

Query: 468 LAYSITLVM 476
           +  +I ++M
Sbjct: 299 IICTIGILM 307


>gi|206725456 zinc activated ligand-gated ion channel [Homo sapiens]
          Length = 412

 Score =  110 bits (274), Expect = 4e-24
 Identities = 80/337 (23%), Positives = 149/337 (44%), Gaps = 17/337 (5%)

Query: 7   MLLW--VQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKP 64
           M LW  +    L   +  LL  G+  +      P+L  ++  L    ++ ++   +   P
Sbjct: 2   MALWSLLHLTFLGFSITLLLVHGQGFQGTAAIWPSLFNVN--LSKKVQESIQIPNNGSAP 59

Query: 65  TTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVP 124
             V + V V  + NVD     +++ +  R  W D  L WN         +++P +S+W P
Sbjct: 60  LLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPRHA-ITLPWESLWTP 118

Query: 125 DILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSW 184
            + I E + V      P   +   G V+    L   T C+ ++ +FP D  NCSL+F + 
Sbjct: 119 RLTILEALWVDWRDQSPQARVDQDGHVKLNLALATETNCNFELLHFPRDHSNCSLSFYAL 178

Query: 185 LHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVI 244
            +T  ++      + E V   R   +            Y  +  +         +  + +
Sbjct: 179 SNTAMELEFQAHVVNEIVSVKREYVV------------YDLKTQVPPQQLVPCFQVTLRL 226

Query: 245 RRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPAT 304
           +   L  +++LL+P+  L++ D+ G  LP  + ER+ +K+TLLL Y V    +   LP++
Sbjct: 227 KNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQALPSS 286

Query: 305 AIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDL 341
           +   PL+  YF + + LL +S  ET+ +  L+ + +L
Sbjct: 287 SSCNPLLIYYFTILLLLLFLSTIETVLLAGLLARGNL 323


>gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Homo
           sapiens]
          Length = 467

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 73/285 (25%), Positives = 124/285 (43%), Gaps = 9/285 (3%)

Query: 64  PTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWV 123
           P  V IDV V +I ++ E N   T   + R YW DE L +      ++T     T  IWV
Sbjct: 82  PVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMTFDHRLTRKIWV 141

Query: 124 PDILI----NEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSL 179
           PDI        F+      NI  + +   G V     + V   C +D   FP D QNCSL
Sbjct: 142 PDIFFVHSKRSFIHDTTMENI-MLRVHPDGNVLLSLRITVSAMCFMDFSRFPLDTQNCSL 200

Query: 180 TFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMK 239
              S+ +   D+ +      + + ++  + ++Q   E          +S  S+ +Y  + 
Sbjct: 201 ELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYS--STGWYNRLF 258

Query: 240 FYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNS-GERVSFKITLLLGYSVFLIIVS 298
              V+RR   F+V+    P+I ++++  V F++   +   RVS  IT +L  S  +  VS
Sbjct: 259 INFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIITAVS 318

Query: 299 DTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQ 343
            ++P  +     + VY  V    + +S+ E   +  L   ++ +Q
Sbjct: 319 ASMPQVSY-LKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQ 362


>gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo
           sapiens]
          Length = 440

 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 83/341 (24%), Positives = 142/341 (41%), Gaps = 31/341 (9%)

Query: 16  LALLLPTLLAQG-----EARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSID 70
           L+L    +  QG     E  RS   + P      + L   Y K +RP     +P  +++ 
Sbjct: 12  LSLFTERMCIQGSQFNVEVGRSDKLSLPGF----ENLTAGYNKFLRP-NFGGEPVQIALT 66

Query: 71  VIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINE 130
           + + +I ++ E N   T  I+ RQ W D+ L +  E   + T  +   + +WVPD  I E
Sbjct: 67  LDIASISSISESNMDYTATIYLRQRWMDQRLVF--EGNKSFTLDARLVEFLWVPDTYIVE 124

Query: 131 F-------VDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTS 183
                   V VG       + +   G V     +    AC++D+  +P D Q C L   S
Sbjct: 125 SKKSFLHEVTVGNR----LIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLES 180

Query: 184 WLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVV 243
           W +   D+  +  R  + V+    + + Q   E    L      S + +  Y  +     
Sbjct: 181 WGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLV---TRSQQETGNYTRLVLQFE 237

Query: 244 IRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNS-GERVSFKITLLLGYSVFLIIVSDTLP 302
           +RR  L++++   +PS FL+V+  V F++  +S   R    +T +L  +  +I    +LP
Sbjct: 238 LRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLP 297

Query: 303 ATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQ 343
            T      I VY  +C + +  +L E      + H   LQQ
Sbjct: 298 NTNCFIKAIDVYLGICFSFVFGALLE----YAVAHYSSLQQ 334


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.139    0.437 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,289,572
Number of Sequences: 37866
Number of extensions: 894999
Number of successful extensions: 3993
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 3792
Number of HSP's gapped (non-prelim): 97
length of query: 484
length of database: 18,247,518
effective HSP length: 106
effective length of query: 378
effective length of database: 14,233,722
effective search space: 5380346916
effective search space used: 5380346916
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.