Search of human proteins with 253735697

Search of human proteins with 253735697

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A
isoform a precursor [Homo sapiens]
         (516 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform...  1045   0.0  
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform...   964   0.0  
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform...   914   0.0  
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor...   356   2e-98
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]   277   1e-74
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]   267   2e-71
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi...   217   2e-56
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]    203   3e-52
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [...   201   2e-51
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [...   200   3e-51
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec...   199   4e-51
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]   197   2e-50
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec...   196   3e-50
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H...   193   4e-49
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ...   191   2e-48
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]     190   2e-48
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec...   189   7e-48
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]   186   3e-47
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre...   175   1e-43
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec...   172   5e-43
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr...   170   3e-42
gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ...   151   1e-36
gi|223468705 5-hydroxytryptamine receptor 3 subunit D isoform 1 ...   144   3e-34
gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p...   140   3e-33
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]              124   2e-28
gi|47519877 5-hydroxytryptamine receptor 3 subunit D isoform 2 [...   116   4e-26
gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]               98   2e-20
gi|206725456 zinc activated ligand-gated ion channel [Homo sapiens]    94   4e-19
gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Hom...    85   1e-16
gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2 prec...    79   8e-15

>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
           precursor [Homo sapiens]
          Length = 516

 Score = 1045 bits (2703), Expect = 0.0
 Identities = 516/516 (100%), Positives = 516/516 (100%)

Query: 1   MLGKLAMLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRD 60
           MLGKLAMLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRD
Sbjct: 1   MLGKLAMLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRD 60

Query: 61  WRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDS 120
           WRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDS
Sbjct: 61  WRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDS 120

Query: 121 IWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLT 180
           IWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLT
Sbjct: 121 IWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLT 180

Query: 181 FTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKF 240
           FTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKF
Sbjct: 181 FTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKF 240

Query: 241 YVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDT 300
           YVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDT
Sbjct: 241 YVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDT 300

Query: 301 LPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAE 360
           LPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAE
Sbjct: 301 LPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAE 360

Query: 361 TIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMG 420
           TIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMG
Sbjct: 361 TIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMG 420

Query: 421 NHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDW 480
           NHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDW
Sbjct: 421 NHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDW 480

Query: 481 LRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA 516
           LRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
Sbjct: 481 LRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA 516


>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
           precursor [Homo sapiens]
          Length = 484

 Score =  964 bits (2493), Expect = 0.0
 Identities = 484/516 (93%), Positives = 484/516 (93%), Gaps = 32/516 (6%)

Query: 1   MLGKLAMLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRD 60
           MLGKLAMLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRD
Sbjct: 1   MLGKLAMLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRD 60

Query: 61  WRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDS 120
           WRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDS
Sbjct: 61  WRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDS 120

Query: 121 IWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLT 180
           IWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLT
Sbjct: 121 IWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLT 180

Query: 181 FTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKF 240
           FTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKF
Sbjct: 181 FTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKF 240

Query: 241 YVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDT 300
           YVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDT
Sbjct: 241 YVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDT 300

Query: 301 LPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAE 360
           LPATAIGTPLI                                GVYFVVCMALLVISLAE
Sbjct: 301 LPATAIGTPLI--------------------------------GVYFVVCMALLVISLAE 328

Query: 361 TIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMG 420
           TIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMG
Sbjct: 329 TIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMG 388

Query: 421 NHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDW 480
           NHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDW
Sbjct: 389 NHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDW 448

Query: 481 LRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA 516
           LRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
Sbjct: 449 LRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA 484


>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
           [Homo sapiens]
          Length = 463

 Score =  914 bits (2361), Expect = 0.0
 Identities = 456/489 (93%), Positives = 457/489 (93%), Gaps = 32/489 (6%)

Query: 28  EARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLT 87
           +ARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLT
Sbjct: 7   QARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLT 66

Query: 88  TYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRH 147
           TYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRH
Sbjct: 67  TYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRH 126

Query: 148 QGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRS 207
           QGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRS
Sbjct: 127 QGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRS 186

Query: 208 VFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDI 267
           VFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDI
Sbjct: 187 VFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDI 246

Query: 268 VGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPA 327
           VGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLI                
Sbjct: 247 VGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLI---------------- 290

Query: 328 PSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLE 387
                           GVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLE
Sbjct: 291 ----------------GVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLE 334

Query: 388 RIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPR 447
           RIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPR
Sbjct: 335 RIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPR 394

Query: 448 EASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLV 507
           EASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLV
Sbjct: 395 EASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLV 454

Query: 508 MLWSIWQYA 516
           MLWSIWQYA
Sbjct: 455 MLWSIWQYA 463


>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
           [Homo sapiens]
          Length = 441

 Score =  356 bits (914), Expect = 2e-98
 Identities = 191/481 (39%), Positives = 278/481 (57%), Gaps = 79/481 (16%)

Query: 39  ALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTD 98
           AL  LS  LL  Y K VRPV +W K TTV +D+ V+AIL+VD +NQ+L T +WY++ W D
Sbjct: 31  ALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWND 90

Query: 99  EFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQ 158
           EFL WN   FD I ++S+P  +IW PDI+INEFVD+ + P++PYVY+   G ++NYKP+Q
Sbjct: 91  EFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQ 150

Query: 159 VVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELL 218
           VV+ACSL+ Y FPFDVQNCSLTF S LHT++D++++  R PE ++ D+  F+N  EWELL
Sbjct: 151 VVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELL 210

Query: 219 GVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGE 278
            V   +      S+  +A+++F VV+RR PL YVVSLL+PSIFLM++D+  FYLPPN   
Sbjct: 211 SVSSTY-SILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRA 269

Query: 279 RVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLAS 338
           R+ FK ++L+GY+VF + +S+ +P +   TPLIG                          
Sbjct: 270 RIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGH------------------------- 304

Query: 339 ALGCTGVYFVVCMALLVISLAETIFIVRLVHKQD---LQQPVPAWLRHLVLERIAWLLCL 395
                  +F +CMA LV+SLA++I +V+ +H +     +QP                LCL
Sbjct: 305 -------FFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQP---------------FLCL 342

Query: 396 REQSTSQRP---PATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLA 452
           R  + + RP   P   +A  T+  S  G H +  G  ++                     
Sbjct: 343 RGDTDADRPRVEPRAQRAVVTES-SLYGEHLAQPGTLKE--------------------- 380

Query: 453 VCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSI 512
              +  +L SI  +L+ +D+  +   +WL + S  D+LLF  YL  +  Y+ITL  LW++
Sbjct: 381 ---VWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSYLFMLGIYTITLCSLWAL 437

Query: 513 W 513
           W
Sbjct: 438 W 438


>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
          Length = 471

 Score =  277 bits (709), Expect = 1e-74
 Identities = 169/465 (36%), Positives = 254/465 (54%), Gaps = 65/465 (13%)

Query: 52  RKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNI 111
           RK  RPV +   PT V+I   + AIL+V+E+  +L++++W    W + F+ WNPE+ + I
Sbjct: 66  RKPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGI 125

Query: 112 TKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFP 171
           TK+S+   ++W+PDI I E +DV K+P     Y+ ++G ++  KP++V + C+LDI+ FP
Sbjct: 126 TKMSMAAKNLWLPDIFIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFP 185

Query: 172 FDVQNCSLTFTSWLHTIQ----DINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREF 227
           FD QNC+LTF+S+L+T+     D+   +W + +   + R++    GEWELLG+     + 
Sbjct: 186 FDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITD---ASRNILQTHGEWELLGLSKATAKL 242

Query: 228 SMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLL 287
           S    N Y ++ FYV IRRRP  YV++LL+PS FL+ +D + FYLP  SG RV FKITLL
Sbjct: 243 S-RGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLL 301

Query: 288 LGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYF 347
           LGY+VFL+++SD LP +  GTPLI                                GVYF
Sbjct: 302 LGYNVFLLMMSDLLPTS--GTPLI--------------------------------GVYF 327

Query: 348 VVCMALLVISLAETIFIVRLVHKQDLQ-QPVPAWLRHLVLERIAWLLCLREQSTSQRPPA 406
            +C++L+V SL ETIFI  L+H    Q  P+P WL  L+L   +   C         P A
Sbjct: 328 ALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLHCNSPGRCC--------PTA 379

Query: 407 TSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQF 466
             +  K       G   +H+ G     K P       P P EA L   G  +   + R+ 
Sbjct: 380 PQKENK-----GPGLTPTHLPG----VKEPEVSAGQMPGPAEAELT--GGSEWTRAQREH 428

Query: 467 LEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWS 511
             ++    E+   WL+    +D +LF +YLL + +  IT++ LW+
Sbjct: 429 EAQKQHSVEL---WLQFSHAMDAMLFRLYLLFMASSIITVICLWN 470


>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
          Length = 447

 Score =  267 bits (683), Expect = 2e-71
 Identities = 161/465 (34%), Positives = 252/465 (54%), Gaps = 74/465 (15%)

Query: 52  RKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNI 111
           RK  RP  ++  PT V+I   + AIL VD + Q+LT+++W    W + F+ WNP++   I
Sbjct: 51  RKAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGI 110

Query: 112 TKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFP 171
            KL++  +++W+PDI I E +DV ++P+    YI  +G ++  KP++V + C+LDI+ FP
Sbjct: 111 NKLTVLAENLWLPDIFIVESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFP 170

Query: 172 FDVQNCSLTFTSWLHTIQDINISL----WRLPEKVKSDRSVFMNQGEWELLGVLPYFREF 227
           FD QNC+ TF+S+L+T+  + + +    W + +   + R V   QGEWELLG+     + 
Sbjct: 171 FDQQNCTFTFSSFLYTVDSMLLGMDKEVWEITD---TSRKVIQTQGEWELLGINKATPKM 227

Query: 228 SMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLL 287
           SM  +N Y ++ FYV IRRRP  Y+++LL+PS FL+ +D + FYLP  S  R  FKITLL
Sbjct: 228 SM-GNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLL 286

Query: 288 LGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYF 347
           LGY+VFL++++D LPA+  GTPLI                                 VYF
Sbjct: 287 LGYNVFLLMMNDLLPAS--GTPLI--------------------------------SVYF 312

Query: 348 VVCMALLVISLAETIFIVRLVHKQDLQ-QPVPAWLRHLVLERIAWLLCLREQSTSQRPPA 406
            +C++L+V+SL ET+FI  L+H    Q  P+P WL  L+L   +   C         P A
Sbjct: 313 ALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSLLLHCTSPGRCC--------PTA 364

Query: 407 TSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQF 466
             +  K      +G   +H+ GP    K P +       PRE          E      +
Sbjct: 365 PQKGNK-----GLGLTLTHLPGP----KEPGELAGKKLGPRET---------EPDGGSGW 406

Query: 467 LEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWS 511
              + ++ E+   W++    +D LLF +YLL + +  +T+++LW+
Sbjct: 407 --TKTQLMEL---WVQFSHAMDTLLFRLYLLFMASSILTVIVLWN 446


>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
           sapiens]
          Length = 450

 Score =  217 bits (553), Expect = 2e-56
 Identities = 146/502 (29%), Positives = 235/502 (46%), Gaps = 75/502 (14%)

Query: 15  LLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVY 74
           LL  LLP      E R +        L+L   L  NY   +RPV D  +   V+++V + 
Sbjct: 13  LLLFLLPAECLGAEGRLA--------LKLFRDLFANYTSALRPVADTDQTLNVTLEVTLS 64

Query: 75  AILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDV 134
            I+++DE+NQVLT Y+W RQ WTD +L+W+P  +  +  + IP+  +W PDI++    D 
Sbjct: 65  QIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADA 124

Query: 135 GKSPNIPY-VYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINI 193
               +    V +RH G V+   P    ++C +D+  FPFD Q+C LTF SW H    +++
Sbjct: 125 QPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDV 184

Query: 194 SLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMES-SNYYAEMKFYVVIRRRPLFYV 252
                P    +  + F+   EW +LG+    R  +    S  Y ++ F +++RRR   YV
Sbjct: 185 R----PRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYV 240

Query: 253 VSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIG 312
            +LLLP + + ++  + F+LP +SGE+VS  +T+LL  +VF +++++++P  A   PLIG
Sbjct: 241 CNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPP-AESVPLIG 299

Query: 313 KAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQD 372
           K                                Y++  M ++  S A TI I+ L +   
Sbjct: 300 K--------------------------------YYMATMTMVTFSTALTILIMNLHYCGP 327

Query: 373 LQQPVPAWLRHLVLERIAWLLCLREQST---SQRPPATSQATKTDDCSAMGNHCSHMGGP 429
             +PVPAW R L+L  +A  LC+RE+       RPP  S +                  P
Sbjct: 328 SVRPVPAWARALLLGHLARGLCVRERGEPCGQSRPPELSPS------------------P 369

Query: 430 QDFEKSPRDRCSPPPPPREASLAVC---GLLQELSSIRQFLEKRDEIREVARDWLRVGSV 486
           Q    SP     PP  P      +C    LL  +++I          +    DW R+  V
Sbjct: 370 Q----SPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWKRLARV 425

Query: 487 LDKLLFHIYLLAVLAYSITLVM 508
           +D+    I+    L  S+ +++
Sbjct: 426 MDRFFLAIFFSMALVMSLLVLV 447


>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
          Length = 494

 Score =  203 bits (517), Expect = 3e-52
 Identities = 127/479 (26%), Positives = 228/479 (47%), Gaps = 64/479 (13%)

Query: 42  RLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFL 101
           RL   L ++Y + +RPV +   P TV  +V +  + NVDE NQ++ T +W R  W D  L
Sbjct: 36  RLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKL 95

Query: 102 QWNPEDFDNITKLSIPTDSIWVPDIL-----INEFVDVGKSPNIPYVYIRHQGEVQNYKP 156
           +W+P ++D I  L +P D IW PDI+     + +F   GK+  +    +++ G +    P
Sbjct: 96  RWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKAL----LKYNGMITWTPP 151

Query: 157 LQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWE 216
               ++C +DI  FPFD QNCSL F SW  T     I L  +  KV  D + F    EWE
Sbjct: 152 AIFKSSCPMDITFFPFDHQNCSLKFGSW--TYDKAEIDLLIIGSKV--DMNDFWENSEWE 207

Query: 217 LLGVLPYFREFSME-SSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPN 275
           ++    Y  +         Y ++ +   IRR P+FY ++L++P +F+  + ++ FYLP +
Sbjct: 208 IIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSD 267

Query: 276 SGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVS 335
            GE+V+  I++LL  +VFL+++++T+P+T++  PL+G+                      
Sbjct: 268 CGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGE---------------------- 305

Query: 336 LASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCL 395
                     Y +  M  + +S+  T+F++ + ++      +P W++ + L+ +  +L +
Sbjct: 306 ----------YLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLM 355

Query: 396 REQSTSQR-------PPATSQATKTDDCSAMG-----NHCSHMGGPQDFEKSPRDRCSPP 443
           R      R       P   ++       ++ G       C H     +   S R R S  
Sbjct: 356 RWPLDKTRGTGSDAVPRGLARRPAKGKLASHGEPRHLKECFHCHKSNELATSKR-RLSHQ 414

Query: 444 P-----PPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLL 497
           P        E S  V  ++  +  I + ++  +E +EV  DW  V  V+D++   ++++
Sbjct: 415 PLQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFII 473


>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
           [Homo sapiens]
          Length = 458

 Score =  201 bits (510), Expect = 2e-51
 Identities = 131/494 (26%), Positives = 236/494 (47%), Gaps = 59/494 (11%)

Query: 15  LLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVY 74
           L+ L +P+    G    + N    ALLR   +L   Y+K VRPV        V   + + 
Sbjct: 9   LIVLGIPSSATTGFNSIAEN--EDALLR---HLFQGYQKWVRPVLHSNDTIKVYFGLKIS 63

Query: 75  AILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDV 134
            +++VDEKNQ++TT +W +Q WTD  L+WNP+D+  I  + +P++S+W+PDI++ E  D 
Sbjct: 64  QLVDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADG 123

Query: 135 G-KSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINI 193
             +   +  V ++  G V    P    ++C++D+  FPFD QNCS+ F SW  T     +
Sbjct: 124 RFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSW--TYDGTMV 181

Query: 194 SLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVV 253
            L  + E V  DR  F + GEWE+L      +    +    Y  + +  V+RR PLFY +
Sbjct: 182 DLILINENV--DRKDFFDNGEWEILNA-KGMKGNRRDGVYSYPFITYSFVLRRLPLFYTL 238

Query: 254 SLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGK 313
            L++P + L  + ++ FYLP + GE++S   ++L+  +VFL+++ + +P+++   PLIG+
Sbjct: 239 FLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGE 298

Query: 314 APPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHK-QD 372
                                           Y +  M  + +S+  T+F++ + H+   
Sbjct: 299 --------------------------------YLLFIMIFVTLSIIVTVFVINVHHRSSS 326

Query: 373 LQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDF 432
              P+  W++ L L+++  LLC+++       P   ++        +             
Sbjct: 327 TYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPEKEESQPVVKGKVL------------- 373

Query: 433 EKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLF 492
           EK  + + S       A L        +  I + ++K   I +V +DW  V  VLD++  
Sbjct: 374 EKKKQKQLSDGEKVLVAFLEKAA--DSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFL 431

Query: 493 HIYLLAVLAYSITL 506
            ++L+  +  S+ +
Sbjct: 432 WLFLIVSVTGSVLI 445


>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
           [Homo sapiens]
          Length = 479

 Score =  200 bits (508), Expect = 3e-51
 Identities = 132/481 (27%), Positives = 226/481 (46%), Gaps = 53/481 (11%)

Query: 42  RLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFL 101
           +L + L  +Y   +RPV D  K   V++ + +  I ++DE+NQ+LT Y+W RQ W D +L
Sbjct: 33  KLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYL 92

Query: 102 QWNPEDFDNITKLSIPTDSIWVPDI-LINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVV 160
            W+ + +D +  + IP+D +W PDI L N+  D    P    V +R+ G +    P    
Sbjct: 93  TWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITK 152

Query: 161 TACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGV 220
           ++C +D+  FPFD Q C+LTF SW +    ++I           D S F+   EWE+ G+
Sbjct: 153 SSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDI----FNALDSGDLSDFIEDVEWEVHGM 208

Query: 221 LPYFREFSME-SSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGER 279
                  S    S  Y ++ F ++++RR  FY+V+LL+P + +  +  + FYLP  SGE+
Sbjct: 209 PAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEK 268

Query: 280 VSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASA 339
           VS  +T+LL  +VF ++V++ +PA+    PLIGK                          
Sbjct: 269 VSLGVTILLAMTVFQLMVAEIMPASE-NVPLIGK-------------------------- 301

Query: 340 LGCTGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLL------ 393
                 Y++  MAL+  S A TI ++ +       +PVP W R ++L+ ++ +L      
Sbjct: 302 ------YYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVG 355

Query: 394 --CLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKS-PRDRCSPPPPPREAS 450
             CL    + +R   T   +K  + +        +   +D  K    D       P+EA 
Sbjct: 356 ESCLSPHHSRERDHLTKVYSKLPESNLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQEAE 415

Query: 451 LAVCG----LLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITL 506
            + C     L + +  I + L+          +W +V  V+D+    I+ + V   +I +
Sbjct: 416 -SYCAQYKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILI 474

Query: 507 V 507
           +
Sbjct: 475 I 475


>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
           precursor [Homo sapiens]
          Length = 502

 Score =  199 bits (507), Expect = 4e-51
 Identities = 125/490 (25%), Positives = 234/490 (47%), Gaps = 64/490 (13%)

Query: 42  RLSDYLL--TNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDE 99
           RL ++LL  + Y K +RP  +  +  TV + V +  +++V E+ Q++TT +W  Q W D 
Sbjct: 31  RLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDY 90

Query: 100 FLQWNPEDFDNITKLSIPTDSIWVPDILINEFVD-VGKSPNIPYVYIRHQGEVQNYKPLQ 158
            L W PE+FDN+ K+ +P+  IW+PD+++    D + +        + + G +    P  
Sbjct: 91  RLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAI 150

Query: 159 VVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELL 218
             +AC +++ +FPFD QNC++ F SW +   +I++ L    +   +    F   GEW+++
Sbjct: 151 YKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVL----KSEVASLDDFTPSGEWDIV 206

Query: 219 GVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGE 278
             LP  R  + + S Y  ++ +  +IRR+PLFY ++L++P + +  + I+ FYLP + GE
Sbjct: 207 A-LPGRRNENPDDSTY-VDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGE 264

Query: 279 RVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLAS 338
           +++  I++LL  +VFL+++S  +P T++  PL+GK                         
Sbjct: 265 KMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGK------------------------- 299

Query: 339 ALGCTGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLL----- 393
                  Y +  M L+  S+  ++ ++ + H+      +  W++ + LE++  LL     
Sbjct: 300 -------YLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQP 352

Query: 394 ---CLREQSTSQRPPAT---------SQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCS 441
              C R++   +R              +A   D C+   N  S  G    F   P     
Sbjct: 353 RHHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAG 412

Query: 442 PPPPPREASLAVCGLLQELSSIR---QFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLA 498
              P R      CGL + +  +R     +   D+ + V+ DW  V  V+D+L   I++  
Sbjct: 413 ---PGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFV 469

Query: 499 VLAYSITLVM 508
            +  +I + +
Sbjct: 470 CVFGTIGMFL 479


>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
          Length = 468

 Score =  197 bits (501), Expect = 2e-50
 Identities = 121/461 (26%), Positives = 214/461 (46%), Gaps = 69/461 (14%)

Query: 47  LLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPE 106
           L  +Y + VRPV        +   + +  +++VDEKNQ++TT +W +Q W D  L+WNP+
Sbjct: 54  LFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPD 113

Query: 107 DFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLD 166
           D+  I  + +P+DS+W PDI++ +  D           IR+ G V    P    ++C++D
Sbjct: 114 DYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTID 173

Query: 167 IYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFRE 226
           +  FPFD+QNCS+ F SW +    ++I L    E    D+  F + GEWE++      + 
Sbjct: 174 VTFFPFDLQNCSMKFGSWTYDGSQVDIIL----EDQDVDKRDFFDNGEWEIVSATG-SKG 228

Query: 227 FSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITL 286
              +S  +Y  + +  VI+R PLFY + L++P I L  + ++ FYLP N GE++    ++
Sbjct: 229 NRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSV 288

Query: 287 LLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVY 346
           L+  +VFL+++ + +P+++   PLIG+                                Y
Sbjct: 289 LVSLTVFLLVIEEIIPSSSKVIPLIGE--------------------------------Y 316

Query: 347 FVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWL-RHLVLERIAWLLCLREQSTSQRPP 405
            V  M  + +S+  T+F + + H+        A L R + L  +  LLC+R         
Sbjct: 317 LVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPKLLCMR--------- 367

Query: 406 ATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQ 465
                             SH+    D   + ++       P+ +   +   L  +  I +
Sbjct: 368 ------------------SHV----DRYFTQKEETESGSGPKSSRNTLEAALDSIRYITR 405

Query: 466 FLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITL 506
            + K +++REV  DW  +  VLD++    +L   +  S+ L
Sbjct: 406 HIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGL 446


>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
           precursor [Homo sapiens]
          Length = 627

 Score =  196 bits (499), Expect = 3e-50
 Identities = 114/388 (29%), Positives = 198/388 (51%), Gaps = 42/388 (10%)

Query: 18  LLLPTLLAQG----EARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIV 73
           LL P LL  G     A     T   A  RL   L + Y K  RPV +      V   + +
Sbjct: 11  LLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSI 70

Query: 74  YAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVD 133
             +++VDEKNQ++TT +W +Q W D  L+W+P D++N+T + IP++ IW PDI++    D
Sbjct: 71  AQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNAD 130

Query: 134 VGKS-PNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDIN 192
              +  ++   ++ H G VQ   P    ++CS+D+  FPFD QNC++ F SW  T     
Sbjct: 131 GDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSW--TYDKAK 188

Query: 193 ISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSME-SSNYYAEMKFYVVIRRRPLFY 251
           I L  +  +V  D+  F   GEW ++  +  +     E  +  Y ++ +  VIRR PLFY
Sbjct: 189 IDLVNMHSRV--DQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFY 246

Query: 252 VVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLI 311
            ++L++P + +  + ++ FYLP   GE+++  I++LL  +VFL+++++ +P+T++  PLI
Sbjct: 247 TINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLI 306

Query: 312 GKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQ 371
           G+                                Y +  M  + +S+  T+F++ + H+ 
Sbjct: 307 GE--------------------------------YLLFTMIFVTLSIVITVFVLNVHHRS 334

Query: 372 DLQQPVPAWLRHLVLERIAWLLCLREQS 399
                +P W+R + L+ +  LL ++  S
Sbjct: 335 PRTHTMPTWVRRVFLDIVPRLLLMKRPS 362



 Score = 31.2 bits (69), Expect = 2.4
 Identities = 16/66 (24%), Positives = 31/66 (46%)

Query: 443 PPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAY 502
           PPP    S A+   ++ +  I   L+  D    V  DW  V  V+D++   ++++  L  
Sbjct: 554 PPPHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLG 613

Query: 503 SITLVM 508
           ++ L +
Sbjct: 614 TVGLFL 619


>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
           sapiens]
          Length = 502

 Score =  193 bits (490), Expect = 4e-49
 Identities = 144/531 (27%), Positives = 236/531 (44%), Gaps = 89/531 (16%)

Query: 14  ALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIV 73
           AL A LL   L QGE +R          +L   L+ NY    RPV +  +P TV   + +
Sbjct: 11  ALAASLLHVSL-QGEFQR----------KLYKELVKNYNPLERPVANDSQPLTVYFSLSL 59

Query: 74  YAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVD 133
             I++VDEKNQVLTT IW +  WTD +LQWN  ++  +  +  P   IW PDIL+    D
Sbjct: 60  LQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSAD 119

Query: 134 VGKSPNI-PYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDIN 192
                     V +   G  Q   P    ++C +D+  FPFDVQ+C L F SW +    ++
Sbjct: 120 ERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLD 179

Query: 193 ISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSME-SSNYYAEMKFYVVIRRRPLFY 251
           + +       ++D S ++  GEW+L+G+     E   E     Y ++ F V +RRR L+Y
Sbjct: 180 LQM------QEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYY 233

Query: 252 VVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLI 311
            ++LL+P + +  + ++ F LP +SGE++S  IT+LL  +VF+++V++ +PAT+   PLI
Sbjct: 234 GLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLI 293

Query: 312 GKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQ 371
            +                                YF   M ++ +S+  T+ +++  H  
Sbjct: 294 AQ--------------------------------YFASTMIIVGLSVVVTVIVLQYHHHD 321

Query: 372 DLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAM------------ 419
                +P W R ++L   AW L ++     +  PA     +    +++            
Sbjct: 322 PDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASN 381

Query: 420 ------------GNHCSHMGGPQDFEKSPRDRCSP----------PPPPREASLAVCGLL 457
                       G HC  +  P       R  CSP           PP  +  LA   +L
Sbjct: 382 GNLLYIGFRGLDGVHC--VPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLA--KIL 437

Query: 458 QELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVM 508
           +E+  I      +DE   V  +W     V+D+L    + +  +  +I ++M
Sbjct: 438 EEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILM 488


>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
           (neuronal) [Homo sapiens]
          Length = 529

 Score =  191 bits (484), Expect = 2e-48
 Identities = 109/379 (28%), Positives = 191/379 (50%), Gaps = 45/379 (11%)

Query: 21  PTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVD 80
           PT L QG +            RL  +L   Y +  RPV +      V   + +  +++VD
Sbjct: 46  PTALPQGGSHTETED------RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVD 99

Query: 81  EKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKS-PN 139
           EKNQ++TT +W +Q W+D  L+WNP DF NIT L +P++ IW+PDI++    D   +  +
Sbjct: 100 EKNQMMTTNVWLKQEWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTH 159

Query: 140 IPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLP 199
           +   ++   G V    P    ++CS+D+  FPFD QNC + F SW  T     I L ++ 
Sbjct: 160 MTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSW--TYDKAKIDLEQME 217

Query: 200 EKVKSDRSVFMNQGEWELLGVLPYFREFSME-SSNYYAEMKFYVVIRRRPLFYVVSLLLP 258
           + V  D   +   GEW ++     +     +  +  Y ++ +  VIRR PLFY ++L++P
Sbjct: 218 QTV--DLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIP 275

Query: 259 SIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGS 318
            + +  + ++ FYLP + GE+++  I++LL  +VFL+++++ +P+T++  PLIG+     
Sbjct: 276 CLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGE----- 330

Query: 319 RAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVP 378
                                      Y +  M  + +S+  T+F++ + H+      +P
Sbjct: 331 ---------------------------YLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMP 363

Query: 379 AWLRHLVLERI-AWLLCLR 396
            W+R  +L  +  WLL  R
Sbjct: 364 HWVRGALLGCVPRWLLMNR 382


>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
          Length = 498

 Score =  190 bits (483), Expect = 2e-48
 Identities = 131/518 (25%), Positives = 239/518 (46%), Gaps = 67/518 (12%)

Query: 14  ALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLL--TNYRKGVRPVRDWRKPTTVSIDV 71
           +L+   L  L  +G  R +      A  +L D LL  T Y   +RP     +  ++ + +
Sbjct: 6   SLVLFFLVALCGRGNCRVAN-----AEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL 60

Query: 72  IVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEF 131
            +  +++V+E+ Q++TT +W +Q WTD  L WN   ++ +  L IP   IW+PDI++   
Sbjct: 61  SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN 120

Query: 132 VDVGKSPNI-PYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQD 190
            D     ++   + +R  G V    P    +AC +++  FPFD QNC+L F SW +   +
Sbjct: 121 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE 180

Query: 191 INISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLF 250
           I++ L   P     D   F   GEW+++  LP  R  + +  +Y  ++ +  +I+R+PLF
Sbjct: 181 IDMVLMT-PTASMDD---FTPSGEWDIVA-LPGRRTVNPQDPSY-VDVTYDFIIKRKPLF 234

Query: 251 YVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPL 310
           Y ++L++P +   ++ I+ FYLP + GE+++  I++LL  + FL+++S  +P T++  PL
Sbjct: 235 YTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPL 294

Query: 311 IGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHK 370
           IGK                                Y +  M L+  S+  ++ ++ + H+
Sbjct: 295 IGK--------------------------------YLMFTMVLVTFSIVTSVCVLNVHHR 322

Query: 371 QDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRP-----PATS-------QATKTDDCSA 418
                 +  W++   L ++   L ++       P     P+ S        AT T   + 
Sbjct: 323 SPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFPPSKSCVTKPEATATSTSPSNF 382

Query: 419 MGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCG--------LLQELSSIRQFLEKR 470
            GN    +       KSP    +P   PR+  L   G         L+ +S I Q ++  
Sbjct: 383 YGNSMYFVNPASAASKSPAGS-TPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKND 441

Query: 471 DEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVM 508
           DE + V  DW  V  V+D+L   +++   +  ++ L +
Sbjct: 442 DEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFL 479


>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
           precursor [Homo sapiens]
          Length = 457

 Score =  189 bits (479), Expect = 7e-48
 Identities = 127/493 (25%), Positives = 232/493 (47%), Gaps = 70/493 (14%)

Query: 18  LLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAIL 77
           LLL +L + G    S + TR     L   L  +Y   VRPV D R+   V++ + +  ++
Sbjct: 7   LLLFSLCSAGLVLGSEHETR-----LVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLI 61

Query: 78  NVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKS 137
           NVDE NQ++TT +  +Q W D  L+WNP+D+  + K+ IP++ IW PD+++    D G  
Sbjct: 62  NVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNAD-GDF 120

Query: 138 PNIPY--VYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISL 195
             + +  V +++ G +    P    + C + + +FPFD QNCS+   +W +    + I+ 
Sbjct: 121 AIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAIN- 179

Query: 196 WRLPEKVKSDRSVFMNQGEWELLGVLPYFRE--FSMESSNYYAEMKFYVVIRRRPLFYVV 253
              PE  + D S FM  GEW +     +     +S      Y ++ ++ V++R PL+++V
Sbjct: 180 ---PESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIV 236

Query: 254 SLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGK 313
           ++++P +    +  + FYLP +SGE+++  I++LL  +VFL+++ + +P+T+   PLIGK
Sbjct: 237 NVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGK 296

Query: 314 APPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQDL 373
                                           Y +  M  ++ S+  T+ ++   H+   
Sbjct: 297 --------------------------------YMLFTMVFVIASIIITVIVINTHHRSPS 324

Query: 374 QQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATK--TDDCSAMGNHCSHMGGPQD 431
              +P W+R + ++ I  ++     ST +RP    Q  K  T+D               D
Sbjct: 325 THVMPNWVRKVFIDTIPNIMFF---STMKRPSREKQDKKIFTEDIDI-----------SD 370

Query: 432 FEKSPRDRCSPPPPPREASL----AVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVL 487
               P     PPP    + L     V   ++ +  I + ++   E    A +W  V  V+
Sbjct: 371 ISGKP----GPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVM 426

Query: 488 DKLLFHIYLLAVL 500
           D +L  +++L  +
Sbjct: 427 DHILLGVFMLVCI 439


>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score =  186 bits (473), Expect = 3e-47
 Identities = 122/515 (23%), Positives = 235/515 (45%), Gaps = 72/515 (13%)

Query: 15  LLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVY 74
           LL LLL +LL    A  + +       RL + L  +Y + +RPV +   P  +  +V + 
Sbjct: 17  LLLLLLLSLLPVARASEAEH-------RLFERLFEDYNEIIRPVANVSDPVIIHFEVSMS 69

Query: 75  AILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILI-NEFVD 133
            ++ VDE NQ++ T +W +Q W D  L+WNP D+     + +P   IW PDI++ N  V 
Sbjct: 70  QLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVG 129

Query: 134 VGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINI 193
             +  +     +++ GEV    P    ++C +D+  FPFD QNC++ F SW +    I++
Sbjct: 130 DFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDL 189

Query: 194 SLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMES-SNYYAEMKFYVVIRRRPLFYV 252
            L      +K     +   GEW ++    Y  +         Y ++ + + IRR PLFY 
Sbjct: 190 VLIGSSMNLKD----YWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYT 245

Query: 253 VSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIG 312
           ++L++P + +  + ++ FYLP + GE+V+  I++LL  +VFL+++++T+P+T++  PLIG
Sbjct: 246 INLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIG 305

Query: 313 KAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQD 372
           +                                Y +  M  + +S+  T+F++ + ++  
Sbjct: 306 E--------------------------------YLLFTMIFVTLSIVITVFVLNVHYRTP 333

Query: 373 LQQPVPAWLRHLVLERIAWLLCL----REQSTSQRP-PATSQATKTDDC----------- 416
               +P+W++ + L  +  ++ +      +  +Q+P P         +C           
Sbjct: 334 TTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKE 393

Query: 417 -----SAMGNHCSHMG-GPQDFEKSPRDRCSPPPPPREASLAVCG-----LLQELSSIRQ 465
                  M  +C H      +F  +     S        SL+         +Q +  I +
Sbjct: 394 GYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAE 453

Query: 466 FLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVL 500
            ++ ++E +E+  DW  V  V+D++   ++ L  +
Sbjct: 454 NMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCI 488


>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
           precursor [Homo sapiens]
          Length = 482

 Score =  175 bits (443), Expect = 1e-43
 Identities = 127/518 (24%), Positives = 232/518 (44%), Gaps = 95/518 (18%)

Query: 18  LLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAIL 77
           LLL +L + G    S + TR     L   L  +Y   VRPV D R+   V++ + +  ++
Sbjct: 7   LLLFSLCSAGLVLGSEHETR-----LVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLI 61

Query: 78  NVDEKNQVLTTYIWYRQ-------------------------YWTDEFLQWNPEDFDNIT 112
           NVDE NQ++TT +  +Q                          W D  L+WNP+D+  + 
Sbjct: 62  NVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVK 121

Query: 113 KLSIPTDSIWVPDILINEFVDVGKSPNIPY--VYIRHQGEVQNYKPLQVVTACSLDIYNF 170
           K+ IP++ IW PD+++    D G    + +  V +++ G +    P    + C + + +F
Sbjct: 122 KIHIPSEKIWRPDLVLYNNAD-GDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF 180

Query: 171 PFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFRE--FS 228
           PFD QNCS+   +W +    + I+    PE  + D S FM  GEW +     +     +S
Sbjct: 181 PFDEQNCSMKLGTWTYDGSVVAIN----PESDQPDLSNFMESGEWVIKESRGWKHSVTYS 236

Query: 229 MESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLL 288
                 Y ++ ++ V++R PL+++V++++P +    +  + FYLP +SGE+++  I++LL
Sbjct: 237 CCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLL 296

Query: 289 GYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFV 348
             +VFL+++ + +P+T+   PLIGK                                Y +
Sbjct: 297 SLTVFLLVIVELIPSTSSAVPLIGK--------------------------------YML 324

Query: 349 VCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATS 408
             M  ++ S+  T+ ++   H+      +P W+R + ++ I  ++     ST +RP    
Sbjct: 325 FTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFF---STMKRPSREK 381

Query: 409 QATK--TDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASL----AVCGLLQELSS 462
           Q  K  T+D               D    P     PPP    + L     V   ++ +  
Sbjct: 382 QDKKIFTEDIDI-----------SDISGKP----GPPPMGFHSPLIKHPEVKSAIEGIKY 426

Query: 463 IRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVL 500
           I + ++   E    A +W  V  V+D +L  +++L  +
Sbjct: 427 IAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCI 464


>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
           precursor [Homo sapiens]
          Length = 501

 Score =  172 bits (437), Expect = 5e-43
 Identities = 116/486 (23%), Positives = 222/486 (45%), Gaps = 67/486 (13%)

Query: 42  RLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFL 101
           RL + L + Y   VRP R+      VS+ +I+  +++++EK++ ++T ++    WTD  L
Sbjct: 29  RLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDYRL 88

Query: 102 QWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPY-VYIRHQGEVQNYKPLQVV 160
            W+P + D I  L I  +S+W+PD+++    D      +   V +   G V+   P    
Sbjct: 89  SWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGIYR 148

Query: 161 TACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPE-----KVKSDRSVFMNQGEW 215
           ++CS+ +  FPFD QNC++ F+S+ +   ++++     P+     ++      F+  G+W
Sbjct: 149 SSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQW 208

Query: 216 ELLGVLPYFREFSMES----SNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFY 271
           E++       +   +          E+ FY++IRR+PLFY+V+++ P I + ++ I  FY
Sbjct: 209 EIIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFY 268

Query: 272 LPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPAPSHL 331
           LPP++GE++   I  LL  +VFL++++D +P T++  P+I K                  
Sbjct: 269 LPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIK------------------ 310

Query: 332 LHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAW 391
                         Y +  M L+  S+  ++ ++ L H+      +P W+R + + ++  
Sbjct: 311 --------------YLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPL 356

Query: 392 LLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASL 451
            L L+        P      +   CS+ G+            K P D   P P   +  L
Sbjct: 357 YLRLKRPK-----PERDLMPEPPHCSSPGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPEL 411

Query: 452 A-------------VCGLLQEL-------SSIRQFLEKRDEIREVARDWLRVGSVLDKLL 491
           +                LL EL       S I + L+++++   +  DW  V  V+D+L 
Sbjct: 412 SAPDLRRFIDGPNRAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLF 471

Query: 492 FHIYLL 497
              +++
Sbjct: 472 LWTFII 477


>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  170 bits (431), Expect = 3e-42
 Identities = 98/280 (35%), Positives = 159/280 (56%), Gaps = 23/280 (8%)

Query: 51  YRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDN 110
           Y K +RPV    +   V++ + +  ++++ E  + LTT +W    WTD  L+WN E+F N
Sbjct: 38  YNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGN 97

Query: 111 ITKLSIPTDSIWVPDILINEFVDVGKSPNIPY---VYIRHQGEVQNYKPLQVVTACSLDI 167
           I+ L +P D +W+P+I++    D   S  I Y   V + H G V    P    ++C + +
Sbjct: 98  ISVLRLPPDMVWLPEIVLENNND--GSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISV 155

Query: 168 YNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKS--------DRSVFMNQGEWELL- 218
             FPFD QNCSL F+S  +T ++I +SL +  ++ ++        D   F   GEWE++ 
Sbjct: 156 TYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVH 215

Query: 219 -----GVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLP 273
                 V P     +   S    ++ FY++IRR+PLFY++++L+P + +  M  + FYLP
Sbjct: 216 RPARVNVDPR----APLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLP 271

Query: 274 PNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGK 313
            +SGE+ S  I++LL  SVFL+++S  LPAT++  PLIGK
Sbjct: 272 ADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGK 311


>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
           precursor [Homo sapiens]
          Length = 493

 Score =  151 bits (382), Expect = 1e-36
 Identities = 115/502 (22%), Positives = 220/502 (43%), Gaps = 78/502 (15%)

Query: 18  LLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAIL 77
           LLL  LL +G  +          LRL  +L  NY  G RPVR+     T+S+ V +  ++
Sbjct: 9   LLLLGLLGRGVGKNEE-------LRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLI 61

Query: 78  NVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVD---- 133
           +++EK + LTT +W    W D  L ++ +DF  I  L +P++ +W+P+I++   +D    
Sbjct: 62  SLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFG 121

Query: 134 VGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINI 193
           V    N   V +   G V    P    + C++++  FPFD QNCSL F S  +  +++  
Sbjct: 122 VAYDAN---VLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEF 178

Query: 194 SL-----WRLPEKVKSDRSVFMNQGEWEL---LGVLPYFREFSMESSNYYAEMKFYVVIR 245
           +       +   K+  D   +   GEW +    GV+      + +      ++ + ++IR
Sbjct: 179 TFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPG-ETDVIYSLIIR 237

Query: 246 RRPLFYVVSLLLPSIFLMVMDIVGFYLPPNS-GERVSFKITLLLGYSVFLIIVSDTLPAT 304
           R+PLFYV+++++P + +  + ++ ++LP  + G++ +  I +LL  +VFL +++  +P T
Sbjct: 238 RKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPET 297

Query: 305 AIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFI 364
           ++  PL+G+                               + FV+ +A L++     + +
Sbjct: 298 SLSVPLLGRF------------------------------LIFVMVVATLIV--MNCVIV 325

Query: 365 VRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCS 424
           + +  +      +   LRH++LE +  LL      +   P A   A+     S++G    
Sbjct: 326 LNVSQRTPTTHAMSPRLRHVLLELLPRLL-----GSPPPPEAPRAASPPRRASSVG---L 377

Query: 425 HMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSS--------------IRQFLEKR 470
            +   +   K PR                    Q L +              + +    +
Sbjct: 378 LLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEVRCCVDAVNFVAESTRDQ 437

Query: 471 DEIREVARDWLRVGSVLDKLLF 492
           +   E   DW+R+G+ LD + F
Sbjct: 438 EATGEEVSDWVRMGNALDNICF 459


>gi|223468705 5-hydroxytryptamine receptor 3 subunit D isoform 1
           [Homo sapiens]
          Length = 404

 Score =  144 bits (362), Expect = 3e-34
 Identities = 132/470 (28%), Positives = 204/470 (43%), Gaps = 86/470 (18%)

Query: 59  RDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPT 118
           R W       +  I++ +L  D   Q++T+++W           WNP++   I K  + T
Sbjct: 3   RGWFHGKGFLLGFILHLLLQ-DSHLQLVTSFLWLNM--------WNPDECGGIKKSGMAT 53

Query: 119 DSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCS 178
           +++W+ D+ I E VD              Q        + +V A S  I    +   + S
Sbjct: 54  ENLWLSDVFIEESVD--------------QTPAGLMASMSIVKATSNTISQCGW---SAS 96

Query: 179 LTFTSWLHTIQDIN------------ISLWRLPEKVKS--DRSVFMNQGEWELLGVLPYF 224
             +T  +    D                 WR   +      R+ F  + EW LLG+    
Sbjct: 97  ANWTPSISPSMDRGERSPSALSPTQVTRAWRRMSRSFQIHHRTSFRTRREWVLLGIQKRT 156

Query: 225 REFSMESSNYYAEMKFYVVIRRR--PLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSF 282
            + ++ ++N Y +  F+V IRRR  P  YVV+ L+PS  L+ +D + FYLP  SG    F
Sbjct: 157 IKVTV-ATNQYEQAIFHVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPF 215

Query: 283 KITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASALGC 342
           K+T+LLGYSVFL++++D LPAT+  +      P  SR Q                     
Sbjct: 216 KMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQK-------------------- 255

Query: 343 TGVYFVVCMALLVISLAETIFIVRLVHKQDLQQ-PVPAWLRHLVLERIAWLLCLREQSTS 401
            GVYF +C++L+V SL ETIFI  L+H    Q  P+P WL  L+L       C       
Sbjct: 256 RGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCC------ 309

Query: 402 QRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELS 461
             P A  +  K       G   +H+ G     K P       P P EA L   G  +   
Sbjct: 310 --PTAPQKGNK-----GPGLTPTHLPG----VKEPEVSAGQMPGPGEAELT--GGSEWTR 356

Query: 462 SIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWS 511
           + R+   ++    E+   W++    +D LLF +YLL + +  IT++ LW+
Sbjct: 357 AQREHEAQKQHSVEL---WVQFSHAMDALLFRLYLLFMASSIITVICLWN 403


>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  140 bits (353), Expect = 3e-33
 Identities = 89/304 (29%), Positives = 154/304 (50%), Gaps = 12/304 (3%)

Query: 18  LLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAIL 77
           LLL  LLA     + RN       RL   L+ NY   +RP         VS+ + +  ++
Sbjct: 8   LLLLLLLAVCLGAQGRNQEE----RLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLI 63

Query: 78  NVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVD-VGK 136
           +++E+ + LTT +W    W D  L+W+P D++ +  L +P+  +W PDI++   VD V +
Sbjct: 64  SLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFE 123

Query: 137 SPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISL- 195
                 V +   G +    P    +ACS+ +  FPFD QNCSL F S  ++  +I++ L 
Sbjct: 124 VALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLS 183

Query: 196 ---WRLPEKVKSDRSVFMNQGEWEL--LGVLPYFREFSMESSNYYAEMKFYVVIRRRPLF 250
               +  E +  D   F   GEW +            +      + ++ FY++I+R+PLF
Sbjct: 184 QEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLF 243

Query: 251 YVVSLLLPSIFLMVMDIVGFYLPPNS-GERVSFKITLLLGYSVFLIIVSDTLPATAIGTP 309
           YV++++ P + +  + I+  +LP  + G++ +  I +LL  +VFL +V+  +P T+   P
Sbjct: 244 YVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVP 303

Query: 310 LIGK 313
           LI K
Sbjct: 304 LISK 307


>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
          Length = 412

 Score =  124 bits (311), Expect = 2e-28
 Identities = 96/401 (23%), Positives = 172/401 (42%), Gaps = 77/401 (19%)

Query: 143 VYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKV 202
           V +   G  Q   P    ++C +D+  FPFDVQ+C L F SW +    +++ +       
Sbjct: 40  VLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQ------ 93

Query: 203 KSDRSVFMNQGEWELLGVLPYFREFSMESSNY-YAEMKFYVVIRRRPLFYVVSLLLPSIF 261
           ++D S ++  GEW+L+G+     E   E     Y ++ F V +RRR L+Y ++LL+P + 
Sbjct: 94  EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVL 153

Query: 262 LMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQ 321
           +  + ++ F LP +SGE++S  IT+LL  +VF+++V++ +PAT+   PLI +        
Sbjct: 154 ISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQ-------- 205

Query: 322 SGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWL 381
                                   YF   M ++ +S+  T+ +++  H       +P W 
Sbjct: 206 ------------------------YFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWT 241

Query: 382 RHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAM---------------------- 419
           R ++L   AW L ++     +  PA     +    +++                      
Sbjct: 242 RVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRG 301

Query: 420 --GNHCSHMGGPQDFEKSPRDRCSP----------PPPPREASLAVCGLLQELSSIRQFL 467
             G HC  +  P       R  CSP           PP  +  LA   +L+E+  I    
Sbjct: 302 LDGVHC--VPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLA--KILEEVRYIANRF 357

Query: 468 EKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVM 508
             +DE   V  +W     V+D+L    + +  +  +I ++M
Sbjct: 358 RCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILM 398


>gi|47519877 5-hydroxytryptamine receptor 3 subunit D isoform 2
           [Homo sapiens]
          Length = 279

 Score =  116 bits (291), Expect = 4e-26
 Identities = 92/273 (33%), Positives = 130/273 (47%), Gaps = 45/273 (16%)

Query: 242 VVIRRR--PLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSD 299
           V IRRR  P  YVV+ L+PS  L+ +D + FYLP  SG    FK+T+LLGYSVFL++++D
Sbjct: 48  VAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMND 107

Query: 300 TLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLA 359
            LPAT+  +      P  SR Q                      GVYF +C++L+V SL 
Sbjct: 108 LLPATSTSSHASLVRPHPSRDQK--------------------RGVYFALCLSLMVGSLL 147

Query: 360 ETIFIVRLVHKQDLQQ-PVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSA 418
           ETIFI  L+H    Q  P+P WL  L+L       C         P A  +  K      
Sbjct: 148 ETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCC--------PTAPQKGNK-----G 194

Query: 419 MGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVAR 478
            G   +H+ G     K P       P P EA L   G  +   + R+   ++    E+  
Sbjct: 195 PGLTPTHLPG----VKEPEVSAGQMPGPGEAELT--GGSEWTRAQREHEAQKQHSVEL-- 246

Query: 479 DWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWS 511
            W++    +D LLF +YLL + +  IT++ LW+
Sbjct: 247 -WVQFSHAMDALLFRLYLLFMASSIITVICLWN 278


>gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
          Length = 321

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 79/341 (23%), Positives = 144/341 (42%), Gaps = 71/341 (20%)

Query: 203 KSDRSVFMNQGEWELLGVLPYFREFSMESSNY-YAEMKFYVVIRRRPLFYVVSLLLPSIF 261
           ++D S ++  GEW+L+G+     E   E     Y ++ F V +RRR L+Y ++LL+P + 
Sbjct: 3   EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVL 62

Query: 262 LMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQ 321
           +  + ++ F LP +SGE++S  IT+LL  +VF+++V++ +PAT+   PLI +        
Sbjct: 63  ISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQ-------- 114

Query: 322 SGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWL 381
                                   YF   M ++ +S+  T+ +++  H       +P W 
Sbjct: 115 ------------------------YFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWT 150

Query: 382 RHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAM---------------------- 419
           R ++L   AW L ++     +  PA     +    +++                      
Sbjct: 151 RVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRG 210

Query: 420 --GNHCSHMGGPQDFEKSPRDRCSP----------PPPPREASLAVCGLLQELSSIRQFL 467
             G HC  +  P       R  CSP           PP  +  LA   +L+E+  I    
Sbjct: 211 LDGVHC--VPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLA--KILEEVRYIANRF 266

Query: 468 EKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVM 508
             +DE   V  +W     V+D+L    + +  +  +I ++M
Sbjct: 267 RCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILM 307


>gi|206725456 zinc activated ligand-gated ion channel [Homo sapiens]
          Length = 412

 Score = 93.6 bits (231), Expect = 4e-19
 Identities = 71/307 (23%), Positives = 132/307 (42%), Gaps = 17/307 (5%)

Query: 7   MLLW--VQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKP 64
           M LW  +    L   +  LL  G+  +      P+L  ++  L    ++ ++   +   P
Sbjct: 2   MALWSLLHLTFLGFSITLLLVHGQGFQGTAAIWPSLFNVN--LSKKVQESIQIPNNGSAP 59

Query: 65  TTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVP 124
             V + V V  + NVD     +++ +  R  W D  L WN         +++P +S+W P
Sbjct: 60  LLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPRHA-ITLPWESLWTP 118

Query: 125 DILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSW 184
            + I E + V      P   +   G V+    L   T C+ ++ +FP D  NCSL+F + 
Sbjct: 119 RLTILEALWVDWRDQSPQARVDQDGHVKLNLALATETNCNFELLHFPRDHSNCSLSFYAL 178

Query: 185 LHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVI 244
            +T  ++      + E V   R   +            Y  +  +         +  + +
Sbjct: 179 SNTAMELEFQAHVVNEIVSVKREYVV------------YDLKTQVPPQQLVPCFQVTLRL 226

Query: 245 RRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPAT 304
           +   L  +++LL+P+  L++ D+ G  LP  + ER+ +K+TLLL Y V    +   LP++
Sbjct: 227 KNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQALPSS 286

Query: 305 AIGTPLI 311
           +   PL+
Sbjct: 287 SSCNPLL 293


>gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Homo
           sapiens]
          Length = 467

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 66/244 (27%), Positives = 108/244 (44%), Gaps = 8/244 (3%)

Query: 64  PTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWV 123
           P  V IDV V +I ++ E N   T   + R YW DE L +      ++T     T  IWV
Sbjct: 82  PVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMTFDHRLTRKIWV 141

Query: 124 PDILI----NEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSL 179
           PDI        F+      NI  + +   G V     + V   C +D   FP D QNCSL
Sbjct: 142 PDIFFVHSKRSFIHDTTMENI-MLRVHPDGNVLLSLRITVSAMCFMDFSRFPLDTQNCSL 200

Query: 180 TFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMK 239
              S+ +   D+ +      + + ++  + ++Q   E          +S  S+ +Y  + 
Sbjct: 201 ELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYS--STGWYNRLF 258

Query: 240 FYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNS-GERVSFKITLLLGYSVFLIIVS 298
              V+RR   F+V+    P+I ++++  V F++   +   RVS  IT +L  S  +  VS
Sbjct: 259 INFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIITAVS 318

Query: 299 DTLP 302
            ++P
Sbjct: 319 ASMP 322


>gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2
           precursor [Homo sapiens]
          Length = 490

 Score = 79.3 bits (194), Expect = 8e-15
 Identities = 57/241 (23%), Positives = 110/241 (45%), Gaps = 8/241 (3%)

Query: 67  VSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDI 126
           V +DV V ++ ++ E +   T  ++ R YW DE L ++     ++T        IWVPD+
Sbjct: 104 VGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASNKSMTFDGRLVKKIWVPDV 163

Query: 127 LI----NEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFT 182
                   F     + NI  + +   G V     + V   C++D  +FP D Q CSL   
Sbjct: 164 FFVHSKRSFTHDTTTDNI-MLRVFPDGHVLYSMRITVTAMCNMDFSHFPLDSQTCSLELE 222

Query: 183 SWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYV 242
           S+ +T +D+ +      E +K+D  + ++Q   +          +S  S+ +Y  +    
Sbjct: 223 SYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRLAFYS--STGWYNRLYINF 280

Query: 243 VIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNS-GERVSFKITLLLGYSVFLIIVSDTL 301
            +RR   F+++    P+  ++++  V F++   +   RVS  IT +L  +  +  V+ ++
Sbjct: 281 TLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITTVLTMTTIITGVNASM 340

Query: 302 P 302
           P
Sbjct: 341 P 341


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.433 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,063,268
Number of Sequences: 37866
Number of extensions: 993097
Number of successful extensions: 4774
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 58
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 4555
Number of HSP's gapped (non-prelim): 125
length of query: 516
length of database: 18,247,518
effective HSP length: 107
effective length of query: 409
effective length of database: 14,195,856
effective search space: 5806105104
effective search space used: 5806105104
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.