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Search of human proteins with 25168263
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1
[Homo sapiens]
(431 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 879 0.0
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 834 0.0
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 833 0.0
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 833 0.0
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 569 e-162
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 569 e-162
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 546 e-155
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 545 e-155
gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [H... 487 e-138
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 350 2e-96
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 348 5e-96
gi|4502023 AKT2 kinase [Homo sapiens] 329 3e-90
gi|62241015 AKT1 kinase [Homo sapiens] 326 3e-89
gi|62241013 AKT1 kinase [Homo sapiens] 326 3e-89
gi|62241011 AKT1 kinase [Homo sapiens] 326 3e-89
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 308 6e-84
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 306 2e-83
gi|4506067 protein kinase C, alpha [Homo sapiens] 299 3e-81
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 299 4e-81
gi|4885563 protein kinase C, epsilon [Homo sapiens] 296 2e-80
gi|133908623 protein kinase C, iota [Homo sapiens] 294 1e-79
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 289 4e-78
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 289 4e-78
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 289 4e-78
gi|13384594 protein kinase C, gamma [Homo sapiens] 288 5e-78
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 287 1e-77
gi|28557781 protein kinase C, eta [Homo sapiens] 286 3e-77
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 284 1e-76
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 283 2e-76
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 283 2e-76
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 879 bits (2271), Expect = 0.0
Identities = 431/431 (100%), Positives = 431/431 (100%)
Query: 1 MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKI 60
MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKI
Sbjct: 1 MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKI 60
Query: 61 SQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAE 120
SQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAE
Sbjct: 61 SQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAE 120
Query: 121 EVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYIN 180
EVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYIN
Sbjct: 121 EVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYIN 180
Query: 181 GGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTD 240
GGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTD
Sbjct: 181 GGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTD 240
Query: 241 FGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR 300
FGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR
Sbjct: 241 FGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR 300
Query: 301 NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINW 360
NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINW
Sbjct: 301 NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINW 360
Query: 361 DDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLG 420
DDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLG
Sbjct: 361 DDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLG 420
Query: 421 FSYAPPTDSFL 431
FSYAPPTDSFL
Sbjct: 421 FSYAPPTDSFL 431
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 834 bits (2154), Expect = 0.0
Identities = 406/407 (99%), Positives = 407/407 (100%)
Query: 25 IAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQIN 84
+AFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQIN
Sbjct: 39 LAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQIN 98
Query: 85 LGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIM 144
LGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIM
Sbjct: 99 LGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIM 158
Query: 145 SERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAA 204
SERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAA
Sbjct: 159 SERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAA 218
Query: 205 EIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYL 264
EIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYL
Sbjct: 219 EIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYL 278
Query: 265 APEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSA 324
APEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSA
Sbjct: 279 APEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSA 338
Query: 325 RHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRH 384
RHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRH
Sbjct: 339 RHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRH 398
Query: 385 FDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 431
FDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
Sbjct: 399 FDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 445
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 833 bits (2153), Expect = 0.0
Identities = 407/408 (99%), Positives = 407/408 (99%)
Query: 24 LIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQI 83
L AFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQI
Sbjct: 52 LKAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQI 111
Query: 84 NLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHI 143
NLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHI
Sbjct: 112 NLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHI 171
Query: 144 MSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYA 203
MSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYA
Sbjct: 172 MSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYA 231
Query: 204 AEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEY 263
AEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEY
Sbjct: 232 AEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEY 291
Query: 264 LAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNS 323
LAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNS
Sbjct: 292 LAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNS 351
Query: 324 ARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLR 383
ARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLR
Sbjct: 352 ARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLR 411
Query: 384 HFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 431
HFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
Sbjct: 412 HFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 459
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 833 bits (2152), Expect = 0.0
Identities = 406/406 (100%), Positives = 406/406 (100%)
Query: 26 AFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINL 85
AFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINL
Sbjct: 121 AFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINL 180
Query: 86 GPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMS 145
GPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMS
Sbjct: 181 GPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMS 240
Query: 146 ERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAE 205
ERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAE
Sbjct: 241 ERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAE 300
Query: 206 IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLA 265
IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLA
Sbjct: 301 IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLA 360
Query: 266 PEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSAR 325
PEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSAR
Sbjct: 361 PEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSAR 420
Query: 326 HLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 385
HLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF
Sbjct: 421 HLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 480
Query: 386 DPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 431
DPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
Sbjct: 481 DPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 526
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 569 bits (1466), Expect = e-162
Identities = 277/411 (67%), Positives = 330/411 (80%), Gaps = 13/411 (3%)
Query: 27 FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPP--------- 77
F+KQRR GLN+FIQ + HP+V++ L++ P+ ++PS
Sbjct: 86 FIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH----QSDPSEDEDERSSQKLH 141
Query: 78 SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKK 137
S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K + FYAVKVLQKK +L +
Sbjct: 142 STSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNR 201
Query: 138 KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEP 197
KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD++NGGELF+HLQRER F E
Sbjct: 202 KEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEH 261
Query: 198 RARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTF 257
RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VLTDFGLCKE I + TT+TF
Sbjct: 262 RARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTF 321
Query: 258 CGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK 317
CGTPEYLAPEV+ KQPYD TVDWWCLGAVLYEMLYGLPPFY R+ AEMYDNIL+KPL L+
Sbjct: 322 CGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLR 381
Query: 318 PNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 377
P ++ +A +LE LL+KDR RLGAK+DF+EI++H FF ++W DL+ KKI PPFNPNV+
Sbjct: 382 PGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVA 441
Query: 378 GPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTD 428
GP+D+R+FD FTEE VP S+ S D +V ASV EA +AF+GFSYAPP++
Sbjct: 442 GPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSE 492
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 569 bits (1466), Expect = e-162
Identities = 277/411 (67%), Positives = 330/411 (80%), Gaps = 13/411 (3%)
Query: 27 FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPP--------- 77
F+KQRR GLN+FIQ + HP+V++ L++ P+ ++PS
Sbjct: 86 FIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH----QSDPSEDEDERSSQKLH 141
Query: 78 SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKK 137
S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K + FYAVKVLQKK +L +
Sbjct: 142 STSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNR 201
Query: 138 KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEP 197
KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD++NGGELF+HLQRER F E
Sbjct: 202 KEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEH 261
Query: 198 RARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTF 257
RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VLTDFGLCKE I + TT+TF
Sbjct: 262 RARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTF 321
Query: 258 CGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK 317
CGTPEYLAPEV+ KQPYD TVDWWCLGAVLYEMLYGLPPFY R+ AEMYDNIL+KPL L+
Sbjct: 322 CGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLR 381
Query: 318 PNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 377
P ++ +A +LE LL+KDR RLGAK+DF+EI++H FF ++W DL+ KKI PPFNPNV+
Sbjct: 382 PGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVA 441
Query: 378 GPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTD 428
GP+D+R+FD FTEE VP S+ S D +V ASV EA +AF+GFSYAPP++
Sbjct: 442 GPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSE 492
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 546 bits (1408), Expect = e-155
Identities = 266/391 (68%), Positives = 321/391 (82%), Gaps = 14/391 (3%)
Query: 52 PEVQSILKISQPQEPEL------MNANPSPPPSPSQQ-----INLGPSSNPHAKPSDFHF 100
P ++ + P PEL MN++P+ PSP INLGPS+NP+A+P+DF F
Sbjct: 38 PPTPTLSCLLLPVPPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDF 97
Query: 101 LKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLV 160
LKVIGKG++GKVLLA+ K++ FYAVKVLQKK+ILKKKE+ HIM+ER+VLLKNV+HPFLV
Sbjct: 98 LKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLV 157
Query: 161 GLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVY 220
GL +SFQT +KLYFVLDY+NGGELF+HLQRER FLEPRARFYAAE+ASA+GYLHSLNI+Y
Sbjct: 158 GLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIY 217
Query: 221 RDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDW 280
RDLKPENILLD QGH+VLTDFGLCKE +E TTSTFCGTPEYLAPEVL K+PYDR VDW
Sbjct: 218 RDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDW 277
Query: 281 WCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL 340
WCLGAVLYEML+GLPPFYS++ ++MY+NIL++PLQ+ T +A LL+ LL KD+ +RL
Sbjct: 278 WCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRL 337
Query: 341 GAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGK 400
G+K DF+EIK+HVFFS INWDDL +K++TPPFNPNV+GP DL+HFDPEFT+E V SIG
Sbjct: 338 GSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGC 397
Query: 401 SPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 431
+PD+V AS A+ AFLGFSYAP D L
Sbjct: 398 TPDTV---ASSSGASSAFLGFSYAPEDDDIL 425
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 545 bits (1404), Expect = e-155
Identities = 261/368 (70%), Positives = 313/368 (85%), Gaps = 8/368 (2%)
Query: 69 MNANPSPPPSPSQQ-----INLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVF 123
MN++P+ PSP INLGPS+NP+A+P+DF FLKVIGKG++GKVLLA+ K++ F
Sbjct: 1 MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF 60
Query: 124 YAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGE 183
YAVKVLQKK+ILKKKE+ HIM+ER+VLLKNV+HPFLVGL +SFQT +KLYFVLDY+NGGE
Sbjct: 61 YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGE 120
Query: 184 LFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGL 243
LF+HLQRER FLEPRARFYAAE+ASA+GYLHSLNI+YRDLKPENILLD QGH+VLTDFGL
Sbjct: 121 LFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL 180
Query: 244 CKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTA 303
CKE +E TTSTFCGTPEYLAPEVL K+PYDR VDWWCLGAVLYEML+GLPPFYS++ +
Sbjct: 181 CKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVS 240
Query: 304 EMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDL 363
+MY+NIL++PLQ+ T +A LL+ LL KD+ +RLG+K DF+EIK+HVFFS INWDDL
Sbjct: 241 QMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDL 300
Query: 364 INKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 423
+K++TPPFNPNV+GP DL+HFDPEFT+E V SIG +PD+V AS A+ AFLGFSY
Sbjct: 301 YHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTV---ASSSGASSAFLGFSY 357
Query: 424 APPTDSFL 431
AP D L
Sbjct: 358 APEDDDIL 365
>gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [Homo
sapiens]
Length = 464
Score = 487 bits (1254), Expect = e-138
Identities = 248/411 (60%), Positives = 300/411 (72%), Gaps = 45/411 (10%)
Query: 27 FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPP--------- 77
F+KQRR GLN+FIQ + HP+V++ L++ P+ ++PS
Sbjct: 86 FIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH----QSDPSEDEDERSSQKLH 141
Query: 78 SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKK 137
S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K + FYAVKVLQKK +L +
Sbjct: 142 STSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNR 201
Query: 138 KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEP 197
KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD++NGGELF+HLQRER F E
Sbjct: 202 KEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEH 261
Query: 198 RARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTF 257
RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VLTDFGLCKE I + TT+TF
Sbjct: 262 RARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTF 321
Query: 258 CGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK 317
CGTPE PPFY R+ AEMYDNIL+KPL L+
Sbjct: 322 CGTPE--------------------------------PPFYCRDVAEMYDNILHKPLSLR 349
Query: 318 PNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 377
P ++ +A +LE LL+KDR RLGAK+DF+EI++H FF ++W DL+ KKI PPFNPNV+
Sbjct: 350 PGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVA 409
Query: 378 GPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTD 428
GP+D+R+FD FTEE VP S+ S D +V ASV EA +AF+GFSYAPP++
Sbjct: 410 GPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSE 460
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 350 bits (897), Expect = 2e-96
Identities = 179/374 (47%), Positives = 241/374 (64%), Gaps = 4/374 (1%)
Query: 54 VQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPS--DFHFLKVIGKGSFGK 111
+Q++ Q QE E MN +P+ + + S+ H + + DF +LK++GKG+FGK
Sbjct: 102 IQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGK 161
Query: 112 VLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADK 171
V+L R KA +YA+K+L+K+ I+ K E H ++E VL KN +HPFL L +SFQT D+
Sbjct: 162 VILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDR 220
Query: 172 LYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLD 231
L FV++Y+NGGELF+HL RER F E R RFY AEI SAL YLHS IVYRDLK EN++LD
Sbjct: 221 LCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLD 280
Query: 232 SQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 291
GHI +TDFGLCKE I +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+
Sbjct: 281 KDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 340
Query: 292 YGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIK 350
G PFY+++ ++++ IL + ++ +++ A+ LL GLL KD KRL G DD EI
Sbjct: 341 CGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIM 400
Query: 351 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTAS 410
H FFS +NW D+ +KK+ PPF P V+ D R+FD EFT + + + + D +
Sbjct: 401 RHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCM 460
Query: 411 VKEAAEAFLGFSYA 424
E F FSY+
Sbjct: 461 DNERRPHFPQFSYS 474
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 348 bits (893), Expect = 5e-96
Identities = 173/344 (50%), Positives = 231/344 (67%), Gaps = 4/344 (1%)
Query: 54 VQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPS--DFHFLKVIGKGSFGK 111
+Q++ Q QE E MN +P+ + + S+ H + + DF +LK++GKG+FGK
Sbjct: 102 IQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGK 161
Query: 112 VLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADK 171
V+L R KA +YA+K+L+K+ I+ K E H ++E VL KN +HPFL L +SFQT D+
Sbjct: 162 VILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDR 220
Query: 172 LYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLD 231
L FV++Y+NGGELF+HL RER F E R RFY AEI SAL YLHS IVYRDLK EN++LD
Sbjct: 221 LCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLD 280
Query: 232 SQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 291
GHI +TDFGLCKE I +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+
Sbjct: 281 KDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 340
Query: 292 YGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIK 350
G PFY+++ ++++ IL + ++ +++ A+ LL GLL KD KRL G DD EI
Sbjct: 341 CGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIM 400
Query: 351 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPV 394
H FFS +NW D+ +KK+ PPF P V+ D R+FD EFT + +
Sbjct: 401 RHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTI 444
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 329 bits (844), Expect = 3e-90
Identities = 168/344 (48%), Positives = 225/344 (65%), Gaps = 4/344 (1%)
Query: 54 VQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPS--DFHFLKVIGKGSFGK 111
V + LK P E + SP S + + S AK + DF +LK++GKG+FGK
Sbjct: 106 VANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGK 165
Query: 112 VLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADK 171
V+L R KA +YA+K+L+K+ I+ K E H ++E VL +N +HPFL L ++FQT D+
Sbjct: 166 VILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL-QNTRHPFLTALKYAFQTHDR 224
Query: 172 LYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLD 231
L FV++Y NGGELF+HL RER F E RARFY AEI SAL YLHS ++VYRD+K EN++LD
Sbjct: 225 LCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLD 284
Query: 232 SQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 291
GHI +TDFGLCKE I +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+
Sbjct: 285 KDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 344
Query: 292 YGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIK 350
G PFY+++ +++ IL + ++ ++ A+ LL GLL+KD +RL G D E+
Sbjct: 345 CGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVM 404
Query: 351 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPV 394
H FF INW D++ KK+ PPF P V+ D R+FD EFT + +
Sbjct: 405 EHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSI 448
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 326 bits (835), Expect = 3e-89
Identities = 172/370 (46%), Positives = 240/370 (64%), Gaps = 7/370 (1%)
Query: 58 LKISQPQEPELMNANPSPPPSPSQQINLGPSSNPH-AKPSDFHFLKVIGKGSFGKVLLAR 116
LK + +E + + +PS S ++++ + + H ++F +LK++GKG+FGKV+L +
Sbjct: 110 LKKQEEEEMDFRSGSPSDN-SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168
Query: 117 HKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVL 176
KA +YA+K+L+K+ I+ K E H ++E VL +N +HPFL L +SFQT D+L FV+
Sbjct: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVM 227
Query: 177 DYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRDLKPENILLDSQGH 235
+Y NGGELF+HL RER F E RARFY AEI SAL YLHS N+VYRDLK EN++LD GH
Sbjct: 228 EYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287
Query: 236 IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLP 295
I +TDFGLCKE I+ +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+ G
Sbjct: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347
Query: 296 PFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIKSHVF 354
PFY+++ ++++ IL + ++ + A+ LL GLL+KD +RL G +D EI H F
Sbjct: 348 PFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407
Query: 355 FSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEA 414
F+ I W + KK++PPF P V+ D R+FD EFT + + + DS+ S E
Sbjct: 408 FAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDS--ER 465
Query: 415 AEAFLGFSYA 424
F FSY+
Sbjct: 466 RPHFPQFSYS 475
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 326 bits (835), Expect = 3e-89
Identities = 172/370 (46%), Positives = 240/370 (64%), Gaps = 7/370 (1%)
Query: 58 LKISQPQEPELMNANPSPPPSPSQQINLGPSSNPH-AKPSDFHFLKVIGKGSFGKVLLAR 116
LK + +E + + +PS S ++++ + + H ++F +LK++GKG+FGKV+L +
Sbjct: 110 LKKQEEEEMDFRSGSPSDN-SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168
Query: 117 HKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVL 176
KA +YA+K+L+K+ I+ K E H ++E VL +N +HPFL L +SFQT D+L FV+
Sbjct: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVM 227
Query: 177 DYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRDLKPENILLDSQGH 235
+Y NGGELF+HL RER F E RARFY AEI SAL YLHS N+VYRDLK EN++LD GH
Sbjct: 228 EYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287
Query: 236 IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLP 295
I +TDFGLCKE I+ +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+ G
Sbjct: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347
Query: 296 PFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIKSHVF 354
PFY+++ ++++ IL + ++ + A+ LL GLL+KD +RL G +D EI H F
Sbjct: 348 PFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407
Query: 355 FSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEA 414
F+ I W + KK++PPF P V+ D R+FD EFT + + + DS+ S E
Sbjct: 408 FAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDS--ER 465
Query: 415 AEAFLGFSYA 424
F FSY+
Sbjct: 466 RPHFPQFSYS 475
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 326 bits (835), Expect = 3e-89
Identities = 172/370 (46%), Positives = 240/370 (64%), Gaps = 7/370 (1%)
Query: 58 LKISQPQEPELMNANPSPPPSPSQQINLGPSSNPH-AKPSDFHFLKVIGKGSFGKVLLAR 116
LK + +E + + +PS S ++++ + + H ++F +LK++GKG+FGKV+L +
Sbjct: 110 LKKQEEEEMDFRSGSPSDN-SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168
Query: 117 HKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVL 176
KA +YA+K+L+K+ I+ K E H ++E VL +N +HPFL L +SFQT D+L FV+
Sbjct: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVM 227
Query: 177 DYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRDLKPENILLDSQGH 235
+Y NGGELF+HL RER F E RARFY AEI SAL YLHS N+VYRDLK EN++LD GH
Sbjct: 228 EYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287
Query: 236 IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLP 295
I +TDFGLCKE I+ +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+ G
Sbjct: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347
Query: 296 PFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIKSHVF 354
PFY+++ ++++ IL + ++ + A+ LL GLL+KD +RL G +D EI H F
Sbjct: 348 PFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407
Query: 355 FSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEA 414
F+ I W + KK++PPF P V+ D R+FD EFT + + + DS+ S E
Sbjct: 408 FAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDS--ER 465
Query: 415 AEAFLGFSYA 424
F FSY+
Sbjct: 466 RPHFPQFSYS 475
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 308 bits (789), Expect = 6e-84
Identities = 163/351 (46%), Positives = 225/351 (64%), Gaps = 18/351 (5%)
Query: 83 INLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEE---VFYAVKVLQKKAILKK-K 138
+N GP +P F L+V+GKG +GKV R +A+KVL+K I++ K
Sbjct: 79 VNRGPEK---IRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK 135
Query: 139 EEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPR 198
+ H +ERN+L + VKHPF+V L ++FQT KLY +L+Y++GGELF L+RE F+E
Sbjct: 136 DTAHTKAERNIL-EEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDT 194
Query: 199 ARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFC 258
A FY AEI+ ALG+LH I+YRDLKPENI+L+ QGH+ LTDFGLCKE+I + T TFC
Sbjct: 195 ACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFC 254
Query: 259 GTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKP 318
GT EY+APE+L + ++R VDWW LGA++Y+ML G PPF N + D IL L L P
Sbjct: 255 GTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPP 314
Query: 319 NITNSARHLLEGLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 377
+T AR LL+ LL+++ RLGA D E+++H FF INW++L+ +K+ PPF P +
Sbjct: 315 YLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQ 374
Query: 378 GPNDLRHFDPEFTEE-PVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPT 427
D+ FD +FT + PV SPD ++ S A + FLGF+Y P+
Sbjct: 375 SEEDVSQFDSKFTRQTPV-----DSPDDSTLSES---ANQVFLGFTYVAPS 417
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 306 bits (785), Expect = 2e-83
Identities = 166/353 (47%), Positives = 228/353 (64%), Gaps = 22/353 (6%)
Query: 83 INLGPSS-NPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEV----FYAVKVLQKKAILKK 137
+N+GP PH F L+V+GKG +GKV R K + YA+KVL+K I++
Sbjct: 55 VNVGPERIGPHC----FELLRVLGKGGYGKVFQVR-KVQGTNLGKIYAMKVLRKAKIVRN 109
Query: 138 -KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLE 196
K+ H +ERN+L ++VKHPF+V L ++FQT KLY +L+ ++GGELF HL+RE FLE
Sbjct: 110 AKDTAHTRAERNIL-ESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLE 168
Query: 197 PRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTST 256
A FY AEI ALG+LHS I+YRDLKPENI+L SQGHI LTDFGLCKE+I + T T
Sbjct: 169 DTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHT 228
Query: 257 FCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQL 316
FCGT EY+APE+L + ++R VDWW LGA++Y+ML G PPF + N + D I+ L L
Sbjct: 229 FCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLAL 288
Query: 317 KPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPN 375
P +T AR L++ L+++ ++R+ G D +++ H FF +NWDDL+ ++ PPF P
Sbjct: 289 PPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPC 348
Query: 376 VSGPNDLRHFDPEFTEE-PVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPT 427
+ D+ FD FT + PV SPD TA + A +AFLGF+Y P+
Sbjct: 349 LQSEEDVSQFDTRFTRQTPV-----DSPDD---TALSESANQAFLGFTYVAPS 393
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 299 bits (766), Expect = 3e-81
Identities = 164/418 (39%), Positives = 241/418 (57%), Gaps = 29/418 (6%)
Query: 27 FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLG 86
FM G+++ ++ A+ Y + E + P+ E N ++ LG
Sbjct: 255 FMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELR---QKFEKAKLG 311
Query: 87 PSSNPHAKPS----------------DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQ 130
P+ N PS DF+FL V+GKGSFGKV+LA K E YA+K+L+
Sbjct: 312 PAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILK 371
Query: 131 KKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQR 190
K +++ + + M E+ VL K PFL LH FQT D+LYFV++Y+NGG+L YH+Q+
Sbjct: 372 KDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQ 431
Query: 191 ERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEH 250
F EP+A FYAAEI+ L +LH I+YRDLK +N++LDS+GHI + DFG+CKE++
Sbjct: 432 VGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMD 491
Query: 251 NSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNIL 310
TT TFCGTP+Y+APE++ QPY ++VDWW G +LYEML G PPF + E++ +I+
Sbjct: 492 GVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIM 551
Query: 311 NKPLQLKPNITNSARHLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKIT 369
+ +++ A + +GL+ K KRLG + +++ H FF I+W+ L N++I
Sbjct: 552 EHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQ 611
Query: 370 PPFNPNVSGPNDLRHFDPEFTE-EPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 426
PPF P V G +FD FT +PV +P LV A++ ++ F GFSY P
Sbjct: 612 PPFKPKVCG-KGAENFDKFFTRGQPV-----LTPPDQLVIANIDQS--DFEGFSYVNP 661
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 299 bits (765), Expect = 4e-81
Identities = 150/334 (44%), Positives = 210/334 (62%), Gaps = 7/334 (2%)
Query: 94 KPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKN 153
K +DF+FL V+GKGSFGKV+L+ K + YAVK+L+K +++ + + M E+ VL
Sbjct: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397
Query: 154 VKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYL 213
K PFL LH FQT D+LYFV++Y+NGG+L YH+Q+ F EP A FYAAEIA L +L
Sbjct: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457
Query: 214 HSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQP 273
S I+YRDLK +N++LDS+GHI + DFG+CKENI TT TFCGTP+Y+APE++ QP
Sbjct: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517
Query: 274 YDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQ 333
Y ++VDWW G +LYEML G PF + E++ +I+ + +++ A + +GL+
Sbjct: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMT 577
Query: 334 KDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 392
K KRLG + +IK H FF I+W+ L K+I PP+ P D +FD EFT +
Sbjct: 578 KHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQ 637
Query: 393 PVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 426
PV +P L ++ + F GFSY P
Sbjct: 638 PVE----LTPTDKLFIMNLDQ--NEFAGFSYTNP 665
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 296 bits (758), Expect = 2e-80
Identities = 152/332 (45%), Positives = 219/332 (65%), Gaps = 13/332 (3%)
Query: 97 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 156
+F+F+KV+GKGSFGKV+LA K ++ YAVKVL+K IL+ + M+E+ +L KH
Sbjct: 407 EFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKH 466
Query: 157 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 216
P+L L+ FQT D+L+FV++Y+NGG+L + +QR R F EPR+RFYAAE+ SAL +LH
Sbjct: 467 PYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQH 526
Query: 217 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 276
++YRDLK +NILLD++GH L DFG+CKE I + TT+TFCGTP+Y+APE+L + Y
Sbjct: 527 GVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGP 586
Query: 277 TVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDR 336
+VDWW LG ++YEM+ G PPF + N +++++IL+ + ++ A +L+ + K+
Sbjct: 587 SVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNP 646
Query: 337 TKRLG---AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFT-EE 392
KRLG +++ IK H FF I+W L KKI PPF P + D+ +FD +FT EE
Sbjct: 647 HKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREE 706
Query: 393 PVPNSIGKSPDSVLVTASVKEA-AEAFLGFSY 423
PV + + A VK+ E F GFSY
Sbjct: 707 PVLTLVDE--------AIVKQINQEEFKGFSY 730
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 294 bits (752), Expect = 1e-79
Identities = 154/374 (41%), Positives = 227/374 (60%), Gaps = 29/374 (7%)
Query: 64 QEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVF 123
+E E MN S S S + DF L+VIG+GS+ KVLL R K +
Sbjct: 232 EEKEAMNTRESGKASSSLGLQ------------DFDLLRVIGRGSYAKVLLVRLKKTDRI 279
Query: 124 YAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGE 183
YA+KV++K+ + ++ + +E++V + HPFLVGLH FQT +L+FV++Y+NGG+
Sbjct: 280 YAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGD 339
Query: 184 LFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGL 243
L +H+QR+R E ARFY+AEI+ AL YLH I+YRDLK +N+LLDS+GHI LTD+G+
Sbjct: 340 LMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGM 399
Query: 244 CKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPF------ 297
CKE + TTSTFCGTP Y+APE+L + Y +VDWW LG +++EM+ G PF
Sbjct: 400 CKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSS 459
Query: 298 --YSRNTAE-MYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGA--KDDFMEIKSH 352
+NT + ++ IL K +++ +++ A +L+ L KD +RLG + F +I+ H
Sbjct: 460 DNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGH 519
Query: 353 VFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVK 412
FF ++WD + K++ PPF PN+SG L +FD +FT EPV +PD + +
Sbjct: 520 PFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQ----LTPDDDDIVRKID 575
Query: 413 EAAEAFLGFSYAPP 426
++ F GF Y P
Sbjct: 576 QS--EFEGFEYINP 587
>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 289 bits (739), Expect = 4e-78
Identities = 147/339 (43%), Positives = 213/339 (62%), Gaps = 15/339 (4%)
Query: 97 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 156
DF ++VIG+GS+ KVLL R K + YA+KV++K+ + ++ + +E++V + +
Sbjct: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
Query: 157 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 216
PFLVGLH FQT +L+ V++Y+NGG+L +H+QR+R E ARFYAAEI AL +LH
Sbjct: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
Query: 217 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 276
I+YRDLK +N+LLD+ GHI LTD+G+CKE + TTSTFCGTP Y+APE+L + Y
Sbjct: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
Query: 277 TVDWWCLGAVLYEMLYGLPPF------YSRNTAE-MYDNILNKPLQLKPNITNSARHLLE 329
+VDWW LG +++EM+ G PF NT + ++ IL KP+++ ++ A H+L+
Sbjct: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
Query: 330 GLLQKDRTKRLGAKDD--FMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDP 387
G L KD +RLG + F +IKSH FF I+WD L K+ PPF P ++ L +FD
Sbjct: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
Query: 388 EFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 426
+FT EPV +PD + ++ F GF Y P
Sbjct: 368 QFTSEPVQ----LTPDDEDAIKRIDQS--EFEGFEYINP 400
>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 289 bits (739), Expect = 4e-78
Identities = 147/339 (43%), Positives = 213/339 (62%), Gaps = 15/339 (4%)
Query: 97 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 156
DF ++VIG+GS+ KVLL R K + YA+KV++K+ + ++ + +E++V + +
Sbjct: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
Query: 157 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 216
PFLVGLH FQT +L+ V++Y+NGG+L +H+QR+R E ARFYAAEI AL +LH
Sbjct: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
Query: 217 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 276
I+YRDLK +N+LLD+ GHI LTD+G+CKE + TTSTFCGTP Y+APE+L + Y
Sbjct: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
Query: 277 TVDWWCLGAVLYEMLYGLPPF------YSRNTAE-MYDNILNKPLQLKPNITNSARHLLE 329
+VDWW LG +++EM+ G PF NT + ++ IL KP+++ ++ A H+L+
Sbjct: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
Query: 330 GLLQKDRTKRLGAKDD--FMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDP 387
G L KD +RLG + F +IKSH FF I+WD L K+ PPF P ++ L +FD
Sbjct: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
Query: 388 EFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 426
+FT EPV +PD + ++ F GF Y P
Sbjct: 368 QFTSEPVQ----LTPDDEDAIKRIDQS--EFEGFEYINP 400
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 289 bits (739), Expect = 4e-78
Identities = 147/339 (43%), Positives = 213/339 (62%), Gaps = 15/339 (4%)
Query: 97 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 156
DF ++VIG+GS+ KVLL R K + YA+KV++K+ + ++ + +E++V + +
Sbjct: 251 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 310
Query: 157 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 216
PFLVGLH FQT +L+ V++Y+NGG+L +H+QR+R E ARFYAAEI AL +LH
Sbjct: 311 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 370
Query: 217 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 276
I+YRDLK +N+LLD+ GHI LTD+G+CKE + TTSTFCGTP Y+APE+L + Y
Sbjct: 371 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 430
Query: 277 TVDWWCLGAVLYEMLYGLPPF------YSRNTAE-MYDNILNKPLQLKPNITNSARHLLE 329
+VDWW LG +++EM+ G PF NT + ++ IL KP+++ ++ A H+L+
Sbjct: 431 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 490
Query: 330 GLLQKDRTKRLGAKDD--FMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDP 387
G L KD +RLG + F +IKSH FF I+WD L K+ PPF P ++ L +FD
Sbjct: 491 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 550
Query: 388 EFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 426
+FT EPV +PD + ++ F GF Y P
Sbjct: 551 QFTSEPVQ----LTPDDEDAIKRIDQS--EFEGFEYINP 583
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 288 bits (738), Expect = 5e-78
Identities = 159/387 (41%), Positives = 231/387 (59%), Gaps = 20/387 (5%)
Query: 48 ACKHP-EVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNP-HAKPSDFHFLKVIG 105
AC +P E+ +++ P PSP PSP+ ++P SDF FL V+G
Sbjct: 304 ACNYPLELYERVRMGPSSSPI-----PSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLG 358
Query: 106 KGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP-----FLV 160
KGSFGKV+LA + + YA+K+L+K I++ + + E+ VL + P FL
Sbjct: 359 KGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLT 418
Query: 161 GLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVY 220
LH +FQT D+LYFV++Y+ GG+L YH+Q+ F EP A FYAAEIA L +LH+ I+Y
Sbjct: 419 QLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIY 478
Query: 221 RDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDW 280
RDLK +N++LD++GHI +TDFG+CKEN+ +TT TFCGTP+Y+APE++ QPY ++VDW
Sbjct: 479 RDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDW 538
Query: 281 WCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL 340
W G +LYEML G PPF + E++ I+ + + +++ A + +G L K KRL
Sbjct: 539 WSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRL 598
Query: 341 GA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIG 399
G+ D I++H FF I+W+ L +I PPF P G + +FD FT +
Sbjct: 599 GSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSG-ENFDKFFTRA----APA 653
Query: 400 KSPDSVLVTASVKEAAEAFLGFSYAPP 426
+P LV AS+ +A F GF+Y P
Sbjct: 654 LTPPDRLVLASIDQA--DFQGFTYVNP 678
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 287 bits (735), Expect = 1e-77
Identities = 141/301 (46%), Positives = 196/301 (65%), Gaps = 2/301 (0%)
Query: 94 KPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKN 153
K +DF+FL V+GKGSFGKV+L+ K + YAVK+L+K +++ + + M E+ VL
Sbjct: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397
Query: 154 VKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYL 213
K PFL LH FQT D+LYFV++Y+NGG+L YH+Q+ F EP A FYAAEIA L +L
Sbjct: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457
Query: 214 HSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQP 273
S I+YRDLK +N++LDS+GHI + DFG+CKENI TT TFCGTP+Y+APE++ QP
Sbjct: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517
Query: 274 YDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQ 333
Y ++VDWW G +LYEML G PF + E++ +I+ + +++ A + +GL+
Sbjct: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMT 577
Query: 334 KDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 392
K KRLG + +IK H FF I+W+ L K+I PP+ P G N +FD FT
Sbjct: 578 KHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRN-AENFDRFFTRH 636
Query: 393 P 393
P
Sbjct: 637 P 637
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 286 bits (731), Expect = 3e-77
Identities = 150/345 (43%), Positives = 213/345 (61%), Gaps = 10/345 (2%)
Query: 85 LGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIM 144
+G +S+ +F F++V+GKGSFGKV+LAR K YAVKVL+K IL+ + + M
Sbjct: 342 IGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTM 401
Query: 145 SERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAA 204
+E+ +L HPFL L FQT D+L+FV++++NGG+L +H+Q+ R F E RARFYAA
Sbjct: 402 TEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAA 461
Query: 205 EIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYL 264
EI SAL +LH I+YRDLK +N+LLD +GH L DFG+CKE I + TT+TFCGTP+Y+
Sbjct: 462 EIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYI 521
Query: 265 APEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSA 324
APE+L + Y VDWW +G +LYEML G PF + N ++++ ILN + + A
Sbjct: 522 APEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDA 581
Query: 325 RHLLEGLLQKDRTKRLGAKDDFME--IKSHVFFSLINWDDLINKKITPPFNPNVSGPNDL 382
+L+ + K+ T RLG+ E I H FF I+W L +++I PPF P + D+
Sbjct: 582 TGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDV 641
Query: 383 RHFDPEF-TEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 426
+FDP+F EEPV I + ++ + F FSY P
Sbjct: 642 SNFDPDFIKEEPVLTPIDEGHLPMI-------NQDEFRNFSYVSP 679
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 284 bits (727), Expect = 1e-76
Identities = 153/339 (45%), Positives = 210/339 (61%), Gaps = 14/339 (4%)
Query: 93 AKPSDFHFLKVIGKGSFGKVLLARHKA---EEVFYAVKVLQKKAILKKKEEKHIMSERNV 149
A PS F LKV+G+GSFGKV L + + YA+KVL KKA LK ++ ER++
Sbjct: 63 ADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVL-KKATLKVRDRVRTKMERDI 121
Query: 150 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 209
L++ V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 122 LVE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 180
Query: 210 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 269
L +LHSL I+YRDLKPENILLD +GHI LTDFGL KE+I+H +FCGT EY+APEV+
Sbjct: 181 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 240
Query: 270 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 329
+++ + ++ DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 241 NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLR 300
Query: 330 GLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 388
L +++ RLGA D EIK H FFS I+W+ L ++I PPF P P D +FDPE
Sbjct: 301 MLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPE 360
Query: 389 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPT 427
FT + +S G P + A + F GFS+ T
Sbjct: 361 FTAKTPKDSPGIPPSA--------NAHQLFRGFSFVAIT 391
Score = 118 bits (296), Expect = 9e-27
Identities = 91/310 (29%), Positives = 146/310 (47%), Gaps = 25/310 (8%)
Query: 104 IGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLH 163
IG GS+ HKA + +AVK++ K ++ E +LL+ +HP ++ L
Sbjct: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKS-------KRDPTEEIEILLRYGQHPNIITLK 480
Query: 164 FSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDL 223
+ +Y V + + GGEL + R++ F E A I + YLH+ +V+RDL
Sbjct: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540
Query: 224 KPENIL-LDSQGH---IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVD 279
KP NIL +D G+ I + DFG K+ N T C T ++APEVL +Q YD D
Sbjct: 541 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACD 600
Query: 280 WWCLGAVLYEMLYGLPPFYS---RNTAEMYDNILNKPLQLK----PNITNSARHLLEGLL 332
W LG +LY ML G PF + E+ I + L +++++A+ L+ +L
Sbjct: 601 IWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKML 660
Query: 333 QKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPN-VSGPNDLRHFDPEFTE 391
D +RL A + H + +++WD L ++ P+ V G + +
Sbjct: 661 HVDPHQRLTA----ALVLRHPW--IVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQ 714
Query: 392 EPVPNSIGKS 401
PV +G+S
Sbjct: 715 SPVLEPVGRS 724
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 283 bits (725), Expect = 2e-76
Identities = 154/335 (45%), Positives = 207/335 (61%), Gaps = 14/335 (4%)
Query: 93 AKPSDFHFLKVIGKGSFGKVLLARH-KAEEV--FYAVKVLQKKAILKKKEEKHIMSERNV 149
A PS F LKV+G+GS+GKV L R K + YA+KVL KKA LK ++ ER++
Sbjct: 62 ADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKMERDI 120
Query: 150 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 209
L + V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 121 LAE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 179
Query: 210 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 269
L +LHSL I+YRDLKPENILLD +GHI +TDFGL KE I+H+ +FCGT EY+APEV+
Sbjct: 180 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 239
Query: 270 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 329
+++ + ++ DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 240 NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLR 299
Query: 330 GLLQKDRTKRLGAK-DDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 388
L +++ RLGA D EIK H FF I+W+ L K+I PPF P V P D HFDPE
Sbjct: 300 ALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPE 359
Query: 389 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 423
FT +S G P + A F GFS+
Sbjct: 360 FTARTPTDSPGVPPSA--------NAHHLFRGFSF 386
Score = 121 bits (303), Expect = 1e-27
Identities = 83/246 (33%), Positives = 118/246 (47%), Gaps = 15/246 (6%)
Query: 56 SILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLA 115
S + S QEP + + P QQ++ +N H + + IG GS+
Sbjct: 385 SFVASSLIQEPSQQDLHKVPVHPIVQQLH---GNNIHFTDG-YEIKEDIGVGSYSVCKRC 440
Query: 116 RHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFV 175
HKA + YAVK++ K ++ E +LL+ +HP ++ L + +Y V
Sbjct: 441 VHKATDTEYAVKIIDKS-------KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLV 493
Query: 176 LDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILL-DSQG 234
++ + GGEL + R+R F E A I + YLHS +V+RDLKP NIL D G
Sbjct: 494 MELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESG 553
Query: 235 ---HIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 291
I + DFG K+ N T C T ++APEVL +Q YD D W LG +LY ML
Sbjct: 554 SPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTML 613
Query: 292 YGLPPF 297
G PF
Sbjct: 614 AGFTPF 619
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 283 bits (725), Expect = 2e-76
Identities = 154/335 (45%), Positives = 207/335 (61%), Gaps = 14/335 (4%)
Query: 93 AKPSDFHFLKVIGKGSFGKVLLARH-KAEEV--FYAVKVLQKKAILKKKEEKHIMSERNV 149
A PS F LKV+G+GS+GKV L R K + YA+KVL KKA LK ++ ER++
Sbjct: 54 ADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKMERDI 112
Query: 150 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 209
L + V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 113 LAE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 171
Query: 210 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 269
L +LHSL I+YRDLKPENILLD +GHI +TDFGL KE I+H+ +FCGT EY+APEV+
Sbjct: 172 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 231
Query: 270 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 329
+++ + ++ DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 232 NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLR 291
Query: 330 GLLQKDRTKRLGAK-DDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 388
L +++ RLGA D EIK H FF I+W+ L K+I PPF P V P D HFDPE
Sbjct: 292 ALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPE 351
Query: 389 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 423
FT +S G P + A F GFS+
Sbjct: 352 FTARTPTDSPGVPPSA--------NAHHLFRGFSF 378
Score = 121 bits (303), Expect = 1e-27
Identities = 83/246 (33%), Positives = 118/246 (47%), Gaps = 15/246 (6%)
Query: 56 SILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLA 115
S + S QEP + + P QQ++ +N H + + IG GS+
Sbjct: 377 SFVASSLIQEPSQQDLHKVPVHPIVQQLH---GNNIHFTDG-YEIKEDIGVGSYSVCKRC 432
Query: 116 RHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFV 175
HKA + YAVK++ K ++ E +LL+ +HP ++ L + +Y V
Sbjct: 433 VHKATDTEYAVKIIDKS-------KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLV 485
Query: 176 LDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILL-DSQG 234
++ + GGEL + R+R F E A I + YLHS +V+RDLKP NIL D G
Sbjct: 486 MELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESG 545
Query: 235 ---HIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 291
I + DFG K+ N T C T ++APEVL +Q YD D W LG +LY ML
Sbjct: 546 SPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTML 605
Query: 292 YGLPPF 297
G PF
Sbjct: 606 AGFTPF 611
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,539,424
Number of Sequences: 37866
Number of extensions: 861433
Number of successful extensions: 6577
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 736
Number of HSP's successfully gapped in prelim test: 96
Number of HSP's that attempted gapping in prelim test: 4098
Number of HSP's gapped (non-prelim): 1100
length of query: 431
length of database: 18,247,518
effective HSP length: 105
effective length of query: 326
effective length of database: 14,271,588
effective search space: 4652537688
effective search space used: 4652537688
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.