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Search of human proteins with 24476016
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24476016 G protein-coupled receptor 161 isoform 2 [Homo
sapiens]
(529 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24476016 G protein-coupled receptor 161 isoform 2 [Homo sapiens] 1060 0.0
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 137 2e-32
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 137 2e-32
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 137 2e-32
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 137 2e-32
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 132 6e-31
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] 132 6e-31
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] 132 6e-31
gi|15150803 opsin 4 isoform 1 [Homo sapiens] 131 1e-30
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 130 4e-30
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 130 4e-30
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 130 4e-30
gi|16876435 G protein-coupled receptor 101 [Homo sapiens] 129 9e-30
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 127 2e-29
gi|71999143 opsin 4 isoform 2 [Homo sapiens] 124 3e-28
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 120 2e-27
gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens] 120 3e-27
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] 120 4e-27
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] 120 4e-27
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] 120 4e-27
gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] 120 4e-27
gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens] 120 4e-27
gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens] 115 1e-25
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 113 4e-25
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] 110 3e-24
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi... 110 3e-24
gi|221139879 G protein-coupled receptor 63 [Homo sapiens] 109 5e-24
gi|13540557 G protein-coupled receptor 63 [Homo sapiens] 109 5e-24
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 107 4e-23
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 103 3e-22
>gi|24476016 G protein-coupled receptor 161 isoform 2 [Homo sapiens]
Length = 529
Score = 1060 bits (2741), Expect = 0.0
Identities = 529/529 (100%), Positives = 529/529 (100%)
Query: 1 MSLNSSLSCRKELSNLTEEEGGEGGVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLT 60
MSLNSSLSCRKELSNLTEEEGGEGGVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLT
Sbjct: 1 MSLNSSLSCRKELSNLTEEEGGEGGVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLT 60
Query: 61 LSNKFVFSLTLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGV 120
LSNKFVFSLTLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGV
Sbjct: 61 LSNKFVFSLTLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGV 120
Query: 121 IAIDRYYAVLYPMVYPMKITGNRAVMALVYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVA 180
IAIDRYYAVLYPMVYPMKITGNRAVMALVYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVA
Sbjct: 121 IAIDRYYAVLYPMVYPMKITGNRAVMALVYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVA 180
Query: 181 AWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQRTGRK 240
AWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQRTGRK
Sbjct: 181 AWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQRTGRK 240
Query: 241 NSSTSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGKSS 300
NSSTSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGKSS
Sbjct: 241 NSSTSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGKSS 300
Query: 301 VSPSLETWATWLSFASAVCHPLIYGLWNKTVRKELLGMCFGDRYYREPFVQRQRTSRLFS 360
VSPSLETWATWLSFASAVCHPLIYGLWNKTVRKELLGMCFGDRYYREPFVQRQRTSRLFS
Sbjct: 301 VSPSLETWATWLSFASAVCHPLIYGLWNKTVRKELLGMCFGDRYYREPFVQRQRTSRLFS 360
Query: 361 ISNRITDLGLSPHLTALMAGGQPLGHSSSTGDTGFSCSQDSGTDMMLLEDYTSDDNPPSH 420
ISNRITDLGLSPHLTALMAGGQPLGHSSSTGDTGFSCSQDSGTDMMLLEDYTSDDNPPSH
Sbjct: 361 ISNRITDLGLSPHLTALMAGGQPLGHSSSTGDTGFSCSQDSGTDMMLLEDYTSDDNPPSH 420
Query: 421 CTCPPKRRSSVTFEDEVEQIKEAAKNSILHVKAEVHKSLDSYAASLAKAIEAEAKINLFG 480
CTCPPKRRSSVTFEDEVEQIKEAAKNSILHVKAEVHKSLDSYAASLAKAIEAEAKINLFG
Sbjct: 421 CTCPPKRRSSVTFEDEVEQIKEAAKNSILHVKAEVHKSLDSYAASLAKAIEAEAKINLFG 480
Query: 481 EEALPGVLVTARTVPGGGFGGRRGSRTLVSQRLQLQSIEEGDVLAAEQR 529
EEALPGVLVTARTVPGGGFGGRRGSRTLVSQRLQLQSIEEGDVLAAEQR
Sbjct: 481 EEALPGVLVTARTVPGGGFGGRRGSRTLVSQRLQLQSIEEGDVLAAEQR 529
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 137 bits (345), Expect = 2e-32
Identities = 82/303 (27%), Positives = 159/303 (52%), Gaps = 9/303 (2%)
Query: 37 ITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSSIRREWIFG 96
+ +F LGN+++++++ +L ++++ ++ +L +++ LL+ VLPF + W FG
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFG 95
Query: 97 VVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMALVYIWLHSL 156
V+CN A + +L +AS++ L +I+IDRY V YP+ YP +T R +MAL+ +W SL
Sbjct: 96 RVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSL 155
Query: 157 IGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVAR 216
+ + PLFGW ++ + + EPGY F + P ++LV Y ++ VA+
Sbjct: 156 VISIGPLFGWRQPAPED---ETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAK 212
Query: 217 VKARKVHCGTVVIVEEDAQ---RTGRKNSSTSTSSSGSRRNAFQ---GVVYSANQCKALI 270
++R + G + Q R RKN+ S S + ++ + + KA
Sbjct: 213 RESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAK 272
Query: 271 TILVVLGAFMVTWGPYMVVIASEALWGKSSVSPSLETWATWLSFASAVCHPLIYGLWNKT 330
T+ +V+G F++ W P+ +V+ + + S ++ WL + ++ +P+IY ++
Sbjct: 273 TLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQE 332
Query: 331 VRK 333
+K
Sbjct: 333 FKK 335
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 137 bits (345), Expect = 2e-32
Identities = 82/303 (27%), Positives = 159/303 (52%), Gaps = 9/303 (2%)
Query: 37 ITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSSIRREWIFG 96
+ +F LGN+++++++ +L ++++ ++ +L +++ LL+ VLPF + W FG
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFG 95
Query: 97 VVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMALVYIWLHSL 156
V+CN A + +L +AS++ L +I+IDRY V YP+ YP +T R +MAL+ +W SL
Sbjct: 96 RVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSL 155
Query: 157 IGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVAR 216
+ + PLFGW ++ + + EPGY F + P ++LV Y ++ VA+
Sbjct: 156 VISIGPLFGWRQPAPED---ETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAK 212
Query: 217 VKARKVHCGTVVIVEEDAQ---RTGRKNSSTSTSSSGSRRNAFQ---GVVYSANQCKALI 270
++R + G + Q R RKN+ S S + ++ + + KA
Sbjct: 213 RESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAK 272
Query: 271 TILVVLGAFMVTWGPYMVVIASEALWGKSSVSPSLETWATWLSFASAVCHPLIYGLWNKT 330
T+ +V+G F++ W P+ +V+ + + S ++ WL + ++ +P+IY ++
Sbjct: 273 TLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQE 332
Query: 331 VRK 333
+K
Sbjct: 333 FKK 335
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 137 bits (345), Expect = 2e-32
Identities = 82/303 (27%), Positives = 159/303 (52%), Gaps = 9/303 (2%)
Query: 37 ITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSSIRREWIFG 96
+ +F LGN+++++++ +L ++++ ++ +L +++ LL+ VLPF + W FG
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFG 95
Query: 97 VVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMALVYIWLHSL 156
V+CN A + +L +AS++ L +I+IDRY V YP+ YP +T R +MAL+ +W SL
Sbjct: 96 RVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSL 155
Query: 157 IGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVAR 216
+ + PLFGW ++ + + EPGY F + P ++LV Y ++ VA+
Sbjct: 156 VISIGPLFGWRQPAPED---ETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAK 212
Query: 217 VKARKVHCGTVVIVEEDAQ---RTGRKNSSTSTSSSGSRRNAFQ---GVVYSANQCKALI 270
++R + G + Q R RKN+ S S + ++ + + KA
Sbjct: 213 RESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAK 272
Query: 271 TILVVLGAFMVTWGPYMVVIASEALWGKSSVSPSLETWATWLSFASAVCHPLIYGLWNKT 330
T+ +V+G F++ W P+ +V+ + + S ++ WL + ++ +P+IY ++
Sbjct: 273 TLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQE 332
Query: 331 VRK 333
+K
Sbjct: 333 FKK 335
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 137 bits (345), Expect = 2e-32
Identities = 82/303 (27%), Positives = 159/303 (52%), Gaps = 9/303 (2%)
Query: 37 ITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSSIRREWIFG 96
+ +F LGN+++++++ +L ++++ ++ +L +++ LL+ VLPF + W FG
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFG 95
Query: 97 VVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMALVYIWLHSL 156
V+CN A + +L +AS++ L +I+IDRY V YP+ YP +T R +MAL+ +W SL
Sbjct: 96 RVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSL 155
Query: 157 IGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVAR 216
+ + PLFGW ++ + + EPGY F + P ++LV Y ++ VA+
Sbjct: 156 VISIGPLFGWRQPAPED---ETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAK 212
Query: 217 VKARKVHCGTVVIVEEDAQ---RTGRKNSSTSTSSSGSRRNAFQ---GVVYSANQCKALI 270
++R + G + Q R RKN+ S S + ++ + + KA
Sbjct: 213 RESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAK 272
Query: 271 TILVVLGAFMVTWGPYMVVIASEALWGKSSVSPSLETWATWLSFASAVCHPLIYGLWNKT 330
T+ +V+G F++ W P+ +V+ + + S ++ WL + ++ +P+IY ++
Sbjct: 273 TLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQE 332
Query: 331 VRK 333
+K
Sbjct: 333 FKK 335
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 132 bits (333), Expect = 6e-31
Identities = 83/318 (26%), Positives = 159/318 (50%), Gaps = 18/318 (5%)
Query: 25 GVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFV 84
G+++ FI +F +GN+++++++ +L T +N F+ +L +++ LLS VLPF
Sbjct: 49 GLVLGAFI------LFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFS 102
Query: 85 VTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRA 144
+ W+ G ++C+ A + +L +AS+L+L I+IDRY V Y + YP +T +A
Sbjct: 103 AALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKA 162
Query: 145 VMALVYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVM 204
++AL+ +W+ S + + PL GW ++ K V EP Y F + P V+
Sbjct: 163 ILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVT---EEPFYALFSSLGSFYIPLAVI 219
Query: 205 LVCYGFIFRVARVKARKVHCGTVVIVEEDAQRTGR---KN------SSTSTSSSGSRRNA 255
LV Y ++ VA+ + + G + + + T R KN SST R +
Sbjct: 220 LVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSI 279
Query: 256 FQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGKSSVSPSLETWATWLSFA 315
+ + + KA T+ +V+G F++ W P+ + + +L+ ++ WL +
Sbjct: 280 AVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYF 339
Query: 316 SAVCHPLIYGLWNKTVRK 333
++ +P+IY +K ++
Sbjct: 340 NSCLNPIIYPCSSKEFKR 357
>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
Length = 397
Score = 132 bits (333), Expect = 6e-31
Identities = 87/314 (27%), Positives = 151/314 (48%), Gaps = 45/314 (14%)
Query: 28 ITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTS 87
IT + + V+ + GN+V+ + + L L+N F+ SL +++ LL +LVLPF
Sbjct: 19 ITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIY 78
Query: 88 SIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMA 147
+ +W FG V+CN L +++ +AS+L L +I++DRY AV+ P+ YP+ +T R ++
Sbjct: 79 QLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAIS 138
Query: 148 LVYIWLHSL-IGCLPPLFGWSSVE--------FDEFKWMCVAAWHREPGYTAFWQIWCAL 198
LV IW+ S+ + L GW+S + K + G F+
Sbjct: 139 LVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFY------ 192
Query: 199 FPFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQRTGRKNSSTSTSSSGSRRNAFQG 258
P L+M + Y IF+VAR +A+++ N +S ++ R +
Sbjct: 193 LPLLIMCITYYRIFKVARDQAKRI------------------NHISSWKAATIREH---- 230
Query: 259 VVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGKSSVSPSLETWATWLSFASAV 318
KA +T+ V+GAF++ W PY L G +++ LE WL +A++
Sbjct: 231 --------KATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSA 282
Query: 319 CHPLIYGLWNKTVR 332
+P++Y N+ R
Sbjct: 283 LNPILYAALNRDFR 296
>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
Length = 359
Score = 132 bits (333), Expect = 6e-31
Identities = 87/314 (27%), Positives = 151/314 (48%), Gaps = 45/314 (14%)
Query: 28 ITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTS 87
IT + + V+ + GN+V+ + + L L+N F+ SL +++ LL +LVLPF
Sbjct: 19 ITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIY 78
Query: 88 SIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMA 147
+ +W FG V+CN L +++ +AS+L L +I++DRY AV+ P+ YP+ +T R ++
Sbjct: 79 QLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAIS 138
Query: 148 LVYIWLHSL-IGCLPPLFGWSSVE--------FDEFKWMCVAAWHREPGYTAFWQIWCAL 198
LV IW+ S+ + L GW+S + K + G F+
Sbjct: 139 LVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFY------ 192
Query: 199 FPFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQRTGRKNSSTSTSSSGSRRNAFQG 258
P L+M + Y IF+VAR +A+++ N +S ++ R +
Sbjct: 193 LPLLIMCITYYRIFKVARDQAKRI------------------NHISSWKAATIREH---- 230
Query: 259 VVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGKSSVSPSLETWATWLSFASAV 318
KA +T+ V+GAF++ W PY L G +++ LE WL +A++
Sbjct: 231 --------KATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSA 282
Query: 319 CHPLIYGLWNKTVR 332
+P++Y N+ R
Sbjct: 283 LNPILYAALNRDFR 296
>gi|15150803 opsin 4 isoform 1 [Homo sapiens]
Length = 478
Score = 131 bits (330), Expect = 1e-30
Identities = 97/338 (28%), Positives = 160/338 (47%), Gaps = 38/338 (11%)
Query: 34 IIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSSIRREW 93
I+++ + LGNL ++ T + L T +N F+ +L +S+FL+S P TSS+ ++W
Sbjct: 77 ILLVGLTGMLGNLTVIYTFCRSRSLRTPANMFIINLAVSDFLMSFTQAPVFFTSSLYKQW 136
Query: 94 IFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMALVYIWL 153
+FG C F A L +SM+TL IA+DRY + P+ + RA L+ +WL
Sbjct: 137 LFGETGCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKRRAAFVLLGVWL 196
Query: 154 HSLIGCLPPLFGWSSVEFDEFKWMCVAAWHR---EPGYTAFWQIWCA---LFPFLVMLVC 207
++L LPP FGWS+ + C +W P A+ + C P L+++ C
Sbjct: 197 YALAWSLPPFFGWSAYVPEGLLTSC--SWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYC 254
Query: 208 YGFIFRVARVKARKVHCGTVVIVEEDAQRTGRKNSSTSTSSSGSRRNAFQGVVYSANQCK 267
Y FIFR R TGR T + G+ + +Q ++CK
Sbjct: 255 YIFIFRAIR-------------------ETGRA-LQTFGACKGNGESLWQRQRLQ-SECK 293
Query: 268 ALITILVVLGAFMVTWGPYMVVIASEALWGKSSV-SPSLETWATWLSFASAVCHPLIYGL 326
+L+V+ F+++W PY V A A G + V +P + + ++ ASA+ +P+IY +
Sbjct: 294 MAKIMLLVILLFVLSWAPYSAV-ALVAFAGYAHVLTPYMSSVPAVIAKASAIHNPIIYAI 352
Query: 327 WNKTVRKEL------LGMCFG-DRYYREPFVQRQRTSR 357
+ R + LG+ G R + P+ + T R
Sbjct: 353 THPKYRVAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHR 390
>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
Length = 432
Score = 130 bits (326), Expect = 4e-30
Identities = 91/314 (28%), Positives = 157/314 (50%), Gaps = 24/314 (7%)
Query: 34 IIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFV-VTSSIRRE 92
+ +IT+ GN ++V+++ L SN + SL L++ ++V V+PFV VT I +
Sbjct: 88 LTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGK 147
Query: 93 WIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMALVYIW 152
WIFG +CN + ++ +AS++TL VI+IDRY + P+ YP++ G ++ +W
Sbjct: 148 WIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVW 207
Query: 153 LHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVMLVCYGFIF 212
L S LPPLFGW+ D+ +C+ + ++ GYT + P VML Y I+
Sbjct: 208 LLSASITLPPLFGWAQNVNDD--KVCLIS--QDFGYTIYSTAVAFYIPMSVMLFMYYQIY 263
Query: 213 RVARVKARKVHCGTVVIVEEDA----------QRTGRKNSSTSTSSSGSRRNAFQGVVYS 262
+ AR A K VE D+ Q+ + ++ S R+N +
Sbjct: 264 KAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKN----ISIF 319
Query: 263 ANQCKALITILVVLGAFMVTWGPYMVVIASEALWGKSSVSPSLETWA----TWLSFASAV 318
+ KA T+ +++GAF V W P+ ++ + +S S + W WL +A+++
Sbjct: 320 KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCS-CIPLWVERTFLWLGYANSL 378
Query: 319 CHPLIYGLWNKTVR 332
+P IY +N+ +R
Sbjct: 379 INPFIYAFFNRDLR 392
>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
Length = 479
Score = 130 bits (326), Expect = 4e-30
Identities = 91/314 (28%), Positives = 157/314 (50%), Gaps = 24/314 (7%)
Query: 34 IIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFV-VTSSIRRE 92
+ +IT+ GN ++V+++ L SN + SL L++ ++V V+PFV VT I +
Sbjct: 88 LTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGK 147
Query: 93 WIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMALVYIW 152
WIFG +CN + ++ +AS++TL VI+IDRY + P+ YP++ G ++ +W
Sbjct: 148 WIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVW 207
Query: 153 LHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVMLVCYGFIF 212
L S LPPLFGW+ D+ +C+ + ++ GYT + P VML Y I+
Sbjct: 208 LLSASITLPPLFGWAQNVNDD--KVCLIS--QDFGYTIYSTAVAFYIPMSVMLFMYYQIY 263
Query: 213 RVARVKARKVHCGTVVIVEEDA----------QRTGRKNSSTSTSSSGSRRNAFQGVVYS 262
+ AR A K VE D+ Q+ + ++ S R+N +
Sbjct: 264 KAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKN----ISIF 319
Query: 263 ANQCKALITILVVLGAFMVTWGPYMVVIASEALWGKSSVSPSLETWA----TWLSFASAV 318
+ KA T+ +++GAF V W P+ ++ + +S S + W WL +A+++
Sbjct: 320 KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCS-CIPLWVERTFLWLGYANSL 378
Query: 319 CHPLIYGLWNKTVR 332
+P IY +N+ +R
Sbjct: 379 INPFIYAFFNRDLR 392
>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
Length = 445
Score = 130 bits (326), Expect = 4e-30
Identities = 91/314 (28%), Positives = 157/314 (50%), Gaps = 24/314 (7%)
Query: 34 IIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFV-VTSSIRRE 92
+ +IT+ GN ++V+++ L SN + SL L++ ++V V+PFV VT I +
Sbjct: 88 LTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGK 147
Query: 93 WIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMALVYIW 152
WIFG +CN + ++ +AS++TL VI+IDRY + P+ YP++ G ++ +W
Sbjct: 148 WIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVW 207
Query: 153 LHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVMLVCYGFIF 212
L S LPPLFGW+ D+ +C+ + ++ GYT + P VML Y I+
Sbjct: 208 LLSASITLPPLFGWAQNVNDD--KVCLIS--QDFGYTIYSTAVAFYIPMSVMLFMYYQIY 263
Query: 213 RVARVKARKVHCGTVVIVEEDA----------QRTGRKNSSTSTSSSGSRRNAFQGVVYS 262
+ AR A K VE D+ Q+ + ++ S R+N +
Sbjct: 264 KAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKN----ISIF 319
Query: 263 ANQCKALITILVVLGAFMVTWGPYMVVIASEALWGKSSVSPSLETWA----TWLSFASAV 318
+ KA T+ +++GAF V W P+ ++ + +S S + W WL +A+++
Sbjct: 320 KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCS-CIPLWVERTFLWLGYANSL 378
Query: 319 CHPLIYGLWNKTVR 332
+P IY +N+ +R
Sbjct: 379 INPFIYAFFNRDLR 392
>gi|16876435 G protein-coupled receptor 101 [Homo sapiens]
Length = 508
Score = 129 bits (323), Expect = 9e-30
Identities = 63/192 (32%), Positives = 107/192 (55%), Gaps = 2/192 (1%)
Query: 25 GVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFV 84
G+I + + I + FV GN+V+ + L +K LL ++N+F+F+L +++ L LV P+V
Sbjct: 31 GIIRSTVLVIFLAASFV--GNIVLALVLQRKPQLLQVTNRFIFNLLVTDLLQISLVAPWV 88
Query: 85 VTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRA 144
V +S+ W +C L L + AS+ T+ V+++DRY ++++P+ YP K+T R
Sbjct: 89 VATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVVSVDRYLSIIHPLSYPSKMTQRRG 148
Query: 145 VMALVYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVM 204
+ L W+ +++ PPL+GW FDE +C W P YT + + P +VM
Sbjct: 149 YLLLYGTWIVAILQSTPPLYGWGQAAFDERNALCSMIWGASPSYTILSVVSFIVIPLIVM 208
Query: 205 LVCYGFIFRVAR 216
+ CY +F AR
Sbjct: 209 IACYSVVFCAAR 220
Score = 48.1 bits (113), Expect = 2e-05
Identities = 25/76 (32%), Positives = 43/76 (56%), Gaps = 3/76 (3%)
Query: 265 QCKALITILVVLGAFMVTWGPYMVVIASEALWG--KSSVSPSLETWATWLSFASAVCHPL 322
QCKA I +++ +++++ GPY +A A+W ++ V + T WL F HP
Sbjct: 394 QCKAAKVIFIIIFSYVLSLGPYCF-LAVLAVWVDVETQVPQWVITIIIWLFFLQCCIHPY 452
Query: 323 IYGLWNKTVRKELLGM 338
+YG +KT++KE+ M
Sbjct: 453 VYGYMHKTIKKEIQDM 468
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 127 bits (320), Expect = 2e-29
Identities = 84/324 (25%), Positives = 157/324 (48%), Gaps = 21/324 (6%)
Query: 25 GVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFV 84
GV + FI + V GNL++++++ +L T++N F+ +L +++ LLS VLPF
Sbjct: 100 GVFLAAFILMAVA------GNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFS 153
Query: 85 VTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRA 144
T + W FG +C+ A + +L +AS+L+L I++DRY V + + YP +T +A
Sbjct: 154 ATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKA 213
Query: 145 VMALVYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVM 204
L +W+ +L+ + PL GW + ++ + E GY F + P V+
Sbjct: 214 AAILALLWVVALVVSVGPLLGWKEPVPPDERFCGIT---EEAGYAVFSSVCSFYLPMAVI 270
Query: 205 LVCYGFIFRVARVKARKVHCG----------TVVIVEEDAQRTGRKNSSTSTSSSGS--R 252
+V Y ++ VAR R + G V+ + TG + S+ G R
Sbjct: 271 VVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFR 330
Query: 253 RNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGKSSVSPSLETWATWL 312
+ ++ + + KA T+ +V+G F++ W P+ V+ +L+ + S + WL
Sbjct: 331 SSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWL 390
Query: 313 SFASAVCHPLIYGLWNKTVRKELL 336
+ ++ +PLIY ++ ++ L
Sbjct: 391 GYFNSCVNPLIYPCSSREFKRAFL 414
>gi|71999143 opsin 4 isoform 2 [Homo sapiens]
Length = 489
Score = 124 bits (310), Expect = 3e-28
Identities = 97/349 (27%), Positives = 161/349 (46%), Gaps = 49/349 (14%)
Query: 34 IIVITIFVCLGNLVIVVT-----------LYKKSYLLTLSNKFVFSLTLSNFLLSVLVLP 82
I+++ + LGNL ++ T + + L T +N F+ +L +S+FL+S P
Sbjct: 77 ILLVGLTGMLGNLTVIYTFCRAVLRGVTVMMQSRSLRTPANMFIINLAVSDFLMSFTQAP 136
Query: 83 FVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGN 142
TSS+ ++W+FG C F A L +SM+TL IA+DRY + P+ +
Sbjct: 137 VFFTSSLYKQWLFGETGCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKR 196
Query: 143 RAVMALVYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHR---EPGYTAFWQIWCA-- 197
RA L+ +WL++L LPP FGWS+ + C +W P A+ + C
Sbjct: 197 RAAFVLLGVWLYALAWSLPPFFGWSAYVPEGLLTSC--SWDYMSFTPAVRAYTMLLCCFV 254
Query: 198 -LFPFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQRTGRKNSSTSTSSSGSRRNAF 256
P L+++ CY FIFR R TGR T + G+ + +
Sbjct: 255 FFLPLLIIIYCYIFIFRAIR-------------------ETGRA-LQTFGACKGNGESLW 294
Query: 257 QGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGKSSV-SPSLETWATWLSFA 315
Q ++CK +L+V+ F+++W PY V A A G + V +P + + ++ A
Sbjct: 295 QRQRLQ-SECKMAKIMLLVILLFVLSWAPYSAV-ALVAFAGYAHVLTPYMSSVPAVIAKA 352
Query: 316 SAVCHPLIYGLWNKTVRKEL------LGMCFG-DRYYREPFVQRQRTSR 357
SA+ +P+IY + + R + LG+ G R + P+ + T R
Sbjct: 353 SAIHNPIIYAITHPKYRVAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHR 401
>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
Length = 390
Score = 120 bits (302), Expect = 2e-27
Identities = 91/347 (26%), Positives = 163/347 (46%), Gaps = 57/347 (16%)
Query: 26 VIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVV 85
V++ +A+I T+ L N ++ T+Y+ L T +N + SL +++ L+S+LV+P
Sbjct: 50 VLLVMLLALI--TLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPIST 107
Query: 86 TSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAV 145
++ W G V C+F + +AS+L L VIA+DRY+A+ + Y K T RA
Sbjct: 108 MYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAA 167
Query: 146 MALVYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVML 205
+ + +W+ S+ LPP F W + +E CV YT + + FP L+++
Sbjct: 168 VMIALVWVFSISISLPPFF-WRQAKAEEEVSECVVNTDHIL-YTVYSTVGAFYFPTLLLI 225
Query: 206 VCYGFIFRVARVKARKVHCGTVVIVEEDAQRTGRK--------NSSTSTSSSGSRRNAFQ 257
YG I+ AR + I+++ RTG++ +S STSS S +
Sbjct: 226 ALYGRIYVEARSR----------ILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVP 275
Query: 258 GV--------------------------VYSANQCKALITILVVLGAFMVTWGPYMVV-- 289
V + +A + KA T+ ++LGAF+V W P+ ++
Sbjct: 276 DVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISL 335
Query: 290 ---IASEALWGKSSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRK 333
I +A W ++ + TWL + +++ +P+IY + N+ ++
Sbjct: 336 VMPICKDACWFHLAIF----DFFTWLGYLNSLINPIIYTMSNEDFKQ 378
>gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]
Length = 388
Score = 120 bits (301), Expect = 3e-27
Identities = 101/387 (26%), Positives = 184/387 (47%), Gaps = 43/387 (11%)
Query: 14 SNLTEEEGG---EGGVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTL-SNKFVFSL 69
+N++ EEG E V++T +I++ I LGNL+++V + L + +N F+ SL
Sbjct: 6 ANVSSEEGFGSVEKVVLLTFLSTVILMAI---LGNLLVMVAVCWDRQLRKIKTNYFIVSL 62
Query: 70 TLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAV 129
++ L+SVLV+PF ++ WI+G V+C L +L+++AS+ L I++DRYYA+
Sbjct: 63 AFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAI 122
Query: 130 -LYPMVYPMKITGNRAVMALVYIW-LHSLIGCLPPLFGWSSV---------EFDEFKWMC 178
P+VY K+T R + L W + + I LP + GW+++ +F++
Sbjct: 123 CCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNST 182
Query: 179 VAAWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQRTG 238
+ Y + PFL+M++ Y I+ A+ A ++ + QR G
Sbjct: 183 YCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQI---------QMLQRAG 233
Query: 239 RKNSSTSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGK 298
+ S S+ + + + KA T+ +++G F + W P+ V + +
Sbjct: 234 ASSESRPQSADQHSTHRMR------TETKAAKTLCIIMGCFCLCWAPFFVTNIVDP-FID 286
Query: 299 SSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRKE-LLGMCFGDRYYREPFVQRQRTSR 357
+V + T WL + ++ +P +Y NK+ R+ L+ +C D YR P + Q
Sbjct: 287 YTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQ---- 342
Query: 358 LFSISNRITDLGLSPHL--TALMAGGQ 382
++ T + S H+ A+ GGQ
Sbjct: 343 --TVPCSTTTINGSTHVLRDAVECGGQ 367
>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
Length = 359
Score = 120 bits (300), Expect = 4e-27
Identities = 94/356 (26%), Positives = 172/356 (48%), Gaps = 35/356 (9%)
Query: 14 SNLTEEEGG---EGGVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTL-SNKFVFSL 69
+N++ EEG E V++T +I++ I LGNL+++V + L + +N F+ SL
Sbjct: 6 ANVSSEEGFGSVEKVVLLTFLSTVILMAI---LGNLLVMVAVCWDRQLRKIKTNYFIVSL 62
Query: 70 TLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAV 129
++ L+SVLV+PF ++ WI+G V+C L +L+++AS+ L I++DRYYA+
Sbjct: 63 AFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAI 122
Query: 130 -LYPMVYPMKITGNRAVMALVYIW-LHSLIGCLPPLFGWSSV---------EFDEFKWMC 178
P+VY K+T R + L W + + I LP + GW+++ +F++
Sbjct: 123 CCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNST 182
Query: 179 VAAWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQRTG 238
+ Y + PFL+M++ Y I+ A+ A ++ + QR G
Sbjct: 183 YCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQI---------QMLQRAG 233
Query: 239 RKNSSTSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGK 298
+ S S+ + + + KA T+ +++G F + W P+ V + +
Sbjct: 234 ASSESRPQSADQHSTHRMR------TETKAAKTLCIIMGCFCLCWAPFFVTNIVDP-FID 286
Query: 299 SSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRKE-LLGMCFGDRYYREPFVQRQ 353
+V + T WL + ++ +P +Y NK+ R+ L+ +C D YR P + Q
Sbjct: 287 YTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQ 342
>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
Length = 428
Score = 120 bits (300), Expect = 4e-27
Identities = 94/356 (26%), Positives = 172/356 (48%), Gaps = 35/356 (9%)
Query: 14 SNLTEEEGG---EGGVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTL-SNKFVFSL 69
+N++ EEG E V++T +I++ I LGNL+++V + L + +N F+ SL
Sbjct: 6 ANVSSEEGFGSVEKVVLLTFLSTVILMAI---LGNLLVMVAVCWDRQLRKIKTNYFIVSL 62
Query: 70 TLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAV 129
++ L+SVLV+PF ++ WI+G V+C L +L+++AS+ L I++DRYYA+
Sbjct: 63 AFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAI 122
Query: 130 -LYPMVYPMKITGNRAVMALVYIW-LHSLIGCLPPLFGWSSV---------EFDEFKWMC 178
P+VY K+T R + L W + + I LP + GW+++ +F++
Sbjct: 123 CCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNST 182
Query: 179 VAAWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQRTG 238
+ Y + PFL+M++ Y I+ A+ A ++ + QR G
Sbjct: 183 YCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQI---------QMLQRAG 233
Query: 239 RKNSSTSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGK 298
+ S S+ + + + KA T+ +++G F + W P+ V + +
Sbjct: 234 ASSESRPQSADQHSTHRMR------TETKAAKTLCIIMGCFCLCWAPFFVTNIVDP-FID 286
Query: 299 SSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRKE-LLGMCFGDRYYREPFVQRQ 353
+V + T WL + ++ +P +Y NK+ R+ L+ +C D YR P + Q
Sbjct: 287 YTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQ 342
>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
Length = 360
Score = 120 bits (300), Expect = 4e-27
Identities = 94/356 (26%), Positives = 172/356 (48%), Gaps = 35/356 (9%)
Query: 14 SNLTEEEGG---EGGVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTL-SNKFVFSL 69
+N++ EEG E V++T +I++ I LGNL+++V + L + +N F+ SL
Sbjct: 6 ANVSSEEGFGSVEKVVLLTFLSTVILMAI---LGNLLVMVAVCWDRQLRKIKTNYFIVSL 62
Query: 70 TLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAV 129
++ L+SVLV+PF ++ WI+G V+C L +L+++AS+ L I++DRYYA+
Sbjct: 63 AFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAI 122
Query: 130 -LYPMVYPMKITGNRAVMALVYIW-LHSLIGCLPPLFGWSSV---------EFDEFKWMC 178
P+VY K+T R + L W + + I LP + GW+++ +F++
Sbjct: 123 CCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNST 182
Query: 179 VAAWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQRTG 238
+ Y + PFL+M++ Y I+ A+ A ++ + QR G
Sbjct: 183 YCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQI---------QMLQRAG 233
Query: 239 RKNSSTSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGK 298
+ S S+ + + + KA T+ +++G F + W P+ V + +
Sbjct: 234 ASSESRPQSADQHSTHRMR------TETKAAKTLCIIMGCFCLCWAPFFVTNIVDP-FID 286
Query: 299 SSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRKE-LLGMCFGDRYYREPFVQRQ 353
+V + T WL + ++ +P +Y NK+ R+ L+ +C D YR P + Q
Sbjct: 287 YTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQ 342
>gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]
Length = 387
Score = 120 bits (300), Expect = 4e-27
Identities = 94/356 (26%), Positives = 172/356 (48%), Gaps = 35/356 (9%)
Query: 14 SNLTEEEGG---EGGVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTL-SNKFVFSL 69
+N++ EEG E V++T +I++ I LGNL+++V + L + +N F+ SL
Sbjct: 6 ANVSSEEGFGSVEKVVLLTFLSTVILMAI---LGNLLVMVAVCWDRQLRKIKTNYFIVSL 62
Query: 70 TLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAV 129
++ L+SVLV+PF ++ WI+G V+C L +L+++AS+ L I++DRYYA+
Sbjct: 63 AFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAI 122
Query: 130 -LYPMVYPMKITGNRAVMALVYIW-LHSLIGCLPPLFGWSSV---------EFDEFKWMC 178
P+VY K+T R + L W + + I LP + GW+++ +F++
Sbjct: 123 CCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNST 182
Query: 179 VAAWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQRTG 238
+ Y + PFL+M++ Y I+ A+ A ++ + QR G
Sbjct: 183 YCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQI---------QMLQRAG 233
Query: 239 RKNSSTSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGK 298
+ S S+ + + + KA T+ +++G F + W P+ V + +
Sbjct: 234 ASSESRPQSADQHSTHRMR------TETKAAKTLCIIMGCFCLCWAPFFVTNIVDP-FID 286
Query: 299 SSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRKE-LLGMCFGDRYYREPFVQRQ 353
+V + T WL + ++ +P +Y NK+ R+ L+ +C D YR P + Q
Sbjct: 287 YTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQ 342
>gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]
Length = 378
Score = 120 bits (300), Expect = 4e-27
Identities = 94/356 (26%), Positives = 172/356 (48%), Gaps = 35/356 (9%)
Query: 14 SNLTEEEGG---EGGVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTL-SNKFVFSL 69
+N++ EEG E V++T +I++ I LGNL+++V + L + +N F+ SL
Sbjct: 6 ANVSSEEGFGSVEKVVLLTFLSTVILMAI---LGNLLVMVAVCWDRQLRKIKTNYFIVSL 62
Query: 70 TLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAV 129
++ L+SVLV+PF ++ WI+G V+C L +L+++AS+ L I++DRYYA+
Sbjct: 63 AFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAI 122
Query: 130 -LYPMVYPMKITGNRAVMALVYIW-LHSLIGCLPPLFGWSSV---------EFDEFKWMC 178
P+VY K+T R + L W + + I LP + GW+++ +F++
Sbjct: 123 CCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNST 182
Query: 179 VAAWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQRTG 238
+ Y + PFL+M++ Y I+ A+ A ++ + QR G
Sbjct: 183 YCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQI---------QMLQRAG 233
Query: 239 RKNSSTSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGK 298
+ S S+ + + + KA T+ +++G F + W P+ V + +
Sbjct: 234 ASSESRPQSADQHSTHRMR------TETKAAKTLCIIMGCFCLCWAPFFVTNIVDP-FID 286
Query: 299 SSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRKE-LLGMCFGDRYYREPFVQRQ 353
+V + T WL + ++ +P +Y NK+ R+ L+ +C D YR P + Q
Sbjct: 287 YTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQ 342
>gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens]
Length = 402
Score = 115 bits (287), Expect = 1e-25
Identities = 101/401 (25%), Positives = 184/401 (45%), Gaps = 57/401 (14%)
Query: 14 SNLTEEEGG---EGGVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTL-SNKFVFSL 69
+N++ EEG E V++T +I++ I LGNL+++V + L + +N F+ SL
Sbjct: 6 ANVSSEEGFGSVEKVVLLTFLSTVILMAI---LGNLLVMVAVCWDRQLRKIKTNYFIVSL 62
Query: 70 TLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAV 129
++ L+SVLV+PF ++ WI+G V+C L +L+++AS+ L I++DRYYA+
Sbjct: 63 AFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAI 122
Query: 130 -LYPMVYPMKITGNRAVMALVYIW-LHSLIGCLPPLFGWSSV------------------ 169
P+VY K+T R + L W + + I LP + GW+++
Sbjct: 123 CCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLERSLNQGLGQDFH 182
Query: 170 -----EFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVARVKARKVHC 224
+F++ + Y + PFL+M++ Y I+ A+ A ++
Sbjct: 183 AIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQI-- 240
Query: 225 GTVVIVEEDAQRTGRKNSSTSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWG 284
+ QR G + S S+ + + + KA T+ +++G F + W
Sbjct: 241 -------QMLQRAGASSESRPQSADQHSTHRMR------TETKAAKTLCIIMGCFCLCWA 287
Query: 285 PYMVVIASEALWGKSSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRKE-LLGMCFGDR 343
P+ V + + +V + T WL + ++ +P +Y NK+ R+ L+ +C D
Sbjct: 288 PFFVTNIVDP-FIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDE 346
Query: 344 YYREPFVQRQRTSRLFSISNRITDLGLSPHL--TALMAGGQ 382
YR P + Q ++ T + S H+ A+ GGQ
Sbjct: 347 RYRRPSILGQ------TVPCSTTTINGSTHVLRDAVECGGQ 381
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 113 bits (283), Expect = 4e-25
Identities = 86/333 (25%), Positives = 153/333 (45%), Gaps = 33/333 (9%)
Query: 28 ITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTS 87
I+ + + VIT+ L N ++ T+ L T +N + SL ++ L+S+LV+P +
Sbjct: 39 ISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAY 98
Query: 88 SIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMA 147
+I W FG + C+ + +AS+L L VIA+DRY+A+ + Y + T A
Sbjct: 99 TITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATM 158
Query: 148 LVYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVMLVC 207
+ +W S+ +PPLF W + E C+ + YT + P +++++
Sbjct: 159 IAIVWAISICISIPPLF-WRQAKAQEEMSDCLVN-TSQISYTIYSTCGAFYIPSVLLIIL 216
Query: 208 YGFIFRVARVKA-------RKVHCGTVVIVEEDAQRTGRKNSSTSTSSSGSRRNA--FQG 258
YG I+R AR + K +I NSS S S + F
Sbjct: 217 YGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNH 276
Query: 259 V-------------VYSANQCKALITILVVLGAFMVTWGPYMVV-----IASEALWGKSS 300
V + +A + KA + ++LGAF++ W P+ VV I ++ W
Sbjct: 277 VKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCW---- 332
Query: 301 VSPSLETWATWLSFASAVCHPLIYGLWNKTVRK 333
+ P+L + TWL + +++ +P+IY ++N+ R+
Sbjct: 333 IHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQ 365
>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
Length = 413
Score = 110 bits (275), Expect = 3e-24
Identities = 76/310 (24%), Positives = 145/310 (46%), Gaps = 28/310 (9%)
Query: 27 IITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVT 86
++ I + +I + + GN++++ + K L T++N F+ SL ++ ++ + V+PF
Sbjct: 33 VVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAA 92
Query: 87 SSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVM 146
+ + W FG WC F + +L +AS+ TL VIA+DRY+A+ P Y +T N+A +
Sbjct: 93 HILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARV 152
Query: 147 ALVYIWLHS-LIGCLPPLFGWSSVEFDE----FKWMCVAAWHREPGYTAFWQIWCALFPF 201
++ +W+ S L LP W E + + Y I P
Sbjct: 153 IILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPL 212
Query: 202 LVMLVCYGFIFRVARVKARKV-------HCGTVVIVEEDAQRTGRKNSSTSTSSSGSRRN 254
++M+ Y +F+ A+ + +K+ H + VE+D RTG G RR+
Sbjct: 213 VIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDG-RTGH----------GLRRS 261
Query: 255 AFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGKSSVSPSLETWATWLSF 314
+ + + KAL T+ +++G F + W P+ +V + + + + W+ +
Sbjct: 262 S----KFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVI-QDNLIRKEVYILLNWIGY 316
Query: 315 ASAVCHPLIY 324
++ +PLIY
Sbjct: 317 VNSGFNPLIY 326
>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
sapiens]
Length = 440
Score = 110 bits (275), Expect = 3e-24
Identities = 109/431 (25%), Positives = 187/431 (43%), Gaps = 52/431 (12%)
Query: 21 GGEGGVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLV 80
GG G V A+ V+ N +++ + + L SN F+ SL S+ ++ ++V
Sbjct: 24 GGSGWVAA----ALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVV 79
Query: 81 LPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKIT 140
+P + +++ W+ C ++ SAS+L L +I++DRY +L P+ Y +++T
Sbjct: 80 MPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMT 139
Query: 141 GNRAVMALVYIW-LHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALF 199
RA+ ++ W L +L LP L GW + H P ++ +L
Sbjct: 140 PLRALALVLGAWSLAALASFLPLLLGWHEL------------GHARPPVPGQCRLLASL- 186
Query: 200 PFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQR-----TGRKNSSTST-------- 246
PF +LV G F + +C ++ + A + TG + ++ T
Sbjct: 187 PF--VLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPR 244
Query: 247 ---SSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGKSSVSP 303
S+ SRR A + +S KA +T+ ++LG F VTW P+ V +A+ +SP
Sbjct: 245 PGVESADSRRLATK---HSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVC--DCISP 299
Query: 304 SLETWATWLSFASAVCHPLIYGLWNKTVRKELLGMCFGDRYYREPFVQRQRTSRLFSISN 363
L TWL + ++ +P+IY L+ + ++ L R+ P R+R + L S S
Sbjct: 300 GLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL------GRFLPCPRCPRERQASLASPSL 353
Query: 364 RITDLGLSPHLTALMAGGQPL-GHSSSTGDTGFSCSQDSGTDMMLLEDYTSDDNPPSHCT 422
R + G P L+ PL S S D G S LL + +PP
Sbjct: 354 RTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPP---- 409
Query: 423 CPPKRRSSVTF 433
P + ++V F
Sbjct: 410 LPTRAAAAVNF 420
>gi|221139879 G protein-coupled receptor 63 [Homo sapiens]
Length = 419
Score = 109 bits (273), Expect = 5e-24
Identities = 79/300 (26%), Positives = 136/300 (45%), Gaps = 22/300 (7%)
Query: 33 AIIVITIFVC-LGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSSIRR 91
AI++ +FV LGNLV+ + +Y+K+ + + N + SL ++ LL+VL +PF + + +
Sbjct: 86 AIMIFILFVSFLGNLVVCLMVYQKAAMRSAINILLASLAFADMLLAVLNMPFALVTILTT 145
Query: 92 EWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMALVYI 151
WIFG +C SA+ + L + L +I+IDR+ ++ K+ RA + +
Sbjct: 146 RWIFGKFFCRVSAMFFWLFVIEGVAILLIISIDRFLIIVQRQ---DKLNPYRAKVLIAVS 202
Query: 152 WLHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAF---WQIWCALFPFLVMLVCY 208
W S P G ++ CV + PGY A+ + PFLV+L +
Sbjct: 203 WATSFCVAFPLAVGNPDLQIPSRAPQCVFGYTTNPGYQAYVILISLISFFIPFLVILYSF 262
Query: 209 GFIFRVARVKARKVHCGTVVIVEEDAQRTGRKNSSTSTSSSGSRRNAFQGVVYSANQCKA 268
I R A ++H I A + G S + FQ + + +A
Sbjct: 263 MGILNTLRHNALRIHSYPEGICLSQASKLGLM----------SLQRPFQMSIDMGFKTRA 312
Query: 269 LITILVVLGAFMVTWGPY----MVVIASEALWGKSSVSPSLETWATWLSFASAVCHPLIY 324
TIL++ F+V W P+ +V S+ + + + + TW WL + + +PLIY
Sbjct: 313 FTTILILFAVFIVCWAPFTTYSLVATFSKHFYYQHNFF-EISTWLLWLCYLKSALNPLIY 371
>gi|13540557 G protein-coupled receptor 63 [Homo sapiens]
Length = 419
Score = 109 bits (273), Expect = 5e-24
Identities = 79/300 (26%), Positives = 136/300 (45%), Gaps = 22/300 (7%)
Query: 33 AIIVITIFVC-LGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSSIRR 91
AI++ +FV LGNLV+ + +Y+K+ + + N + SL ++ LL+VL +PF + + +
Sbjct: 86 AIMIFILFVSFLGNLVVCLMVYQKAAMRSAINILLASLAFADMLLAVLNMPFALVTILTT 145
Query: 92 EWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMALVYI 151
WIFG +C SA+ + L + L +I+IDR+ ++ K+ RA + +
Sbjct: 146 RWIFGKFFCRVSAMFFWLFVIEGVAILLIISIDRFLIIVQRQ---DKLNPYRAKVLIAVS 202
Query: 152 WLHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAF---WQIWCALFPFLVMLVCY 208
W S P G ++ CV + PGY A+ + PFLV+L +
Sbjct: 203 WATSFCVAFPLAVGNPDLQIPSRAPQCVFGYTTNPGYQAYVILISLISFFIPFLVILYSF 262
Query: 209 GFIFRVARVKARKVHCGTVVIVEEDAQRTGRKNSSTSTSSSGSRRNAFQGVVYSANQCKA 268
I R A ++H I A + G S + FQ + + +A
Sbjct: 263 MGILNTLRHNALRIHSYPEGICLSQASKLGLM----------SLQRPFQMSIDMGFKTRA 312
Query: 269 LITILVVLGAFMVTWGPY----MVVIASEALWGKSSVSPSLETWATWLSFASAVCHPLIY 324
TIL++ F+V W P+ +V S+ + + + + TW WL + + +PLIY
Sbjct: 313 FTTILILFAVFIVCWAPFTTYSLVATFSKHFYYQHNFF-EISTWLLWLCYLKSALNPLIY 371
>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
sapiens]
Length = 422
Score = 107 bits (266), Expect = 4e-23
Identities = 62/191 (32%), Positives = 100/191 (52%), Gaps = 4/191 (2%)
Query: 33 AIIVITIFVC--LGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSSIR 90
++++ T+ C LGN +V + + L ++N + SL +++ ++SVLVLP +
Sbjct: 40 SLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVL 99
Query: 91 REWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMALVY 150
+W G V C+ L +L ++S+L L IA+DRY+A+ P+ Y K T RA +
Sbjct: 100 NKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISL 159
Query: 151 IWLHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVMLVCYGF 210
WL + +PP+ GW + E C + ++ GYT + P L+MLV YG
Sbjct: 160 TWLIGFLISIPPMLGWRTPEDRSDPDACTIS--KDHGYTIYSTFGAFYIPLLLMLVLYGR 217
Query: 211 IFRVARVKARK 221
IFR AR + RK
Sbjct: 218 IFRAARFRIRK 228
Score = 38.1 bits (87), Expect = 0.020
Identities = 18/68 (26%), Positives = 37/68 (54%), Gaps = 1/68 (1%)
Query: 263 ANQCKALITILVVLGAFMVTWGPYMVVIASEALWGKSSVSPS-LETWATWLSFASAVCHP 321
A + K + T+ +++G F++ W P+ +V S P+ L WL +++++ +P
Sbjct: 338 ARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNP 397
Query: 322 LIYGLWNK 329
+IY +NK
Sbjct: 398 VIYAYFNK 405
>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
sapiens]
Length = 366
Score = 103 bits (258), Expect = 3e-22
Identities = 84/335 (25%), Positives = 152/335 (45%), Gaps = 44/335 (13%)
Query: 32 IAIIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSSIRR 91
+A++ TI N +++ + L +N + SL +++FL++VLV+PF + +R
Sbjct: 33 LALMTTTI-----NSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRE 87
Query: 92 EWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMALVYI 151
WI G V C+ + + + S+L L IA+DRY A+ + Y K T A + + +
Sbjct: 88 SWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMITIV 147
Query: 152 WLHSLIGCLPPLFGW---SSVEFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVMLVCY 208
W+ S+ +PPLF W + DE C+ H T + P ++L+ Y
Sbjct: 148 WIISVFISMPPLF-WRHQGTSRDDE----CIIK-HDHIVSTIYSTFGAFYIPLALILILY 201
Query: 209 GFIFRVARVKARKVHCGTVVIVEEDAQ---RTGRKNS-STSTS----------------- 247
I+R A+ K + E + Q +G K++ S STS
Sbjct: 202 YKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKI 261
Query: 248 --SSGSRRNAFQGV-------VYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGK 298
+ S R+ F+ + + KA T+ ++LGAF++ W P+ V + K
Sbjct: 262 HSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDK 321
Query: 299 SSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRK 333
+S + + WL + +++ +PLIY ++N+ +K
Sbjct: 322 CKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKK 356
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.136 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,965,158
Number of Sequences: 37866
Number of extensions: 795759
Number of successful extensions: 3513
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 517
Number of HSP's successfully gapped in prelim test: 109
Number of HSP's that attempted gapping in prelim test: 2372
Number of HSP's gapped (non-prelim): 936
length of query: 529
length of database: 18,247,518
effective HSP length: 107
effective length of query: 422
effective length of database: 14,195,856
effective search space: 5990651232
effective search space used: 5990651232
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.