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Search of human proteins with 24430181
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24430181 outer dense fiber of sperm tails 2 isoform 1 [Homo
sapiens]
(805 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24430181 outer dense fiber of sperm tails 2 isoform 1 [Homo s... 1553 0.0
gi|24430183 outer dense fiber of sperm tails 2 isoform 2 [Homo s... 1116 0.0
gi|55749696 outer dense fiber of sperm tails 2-like isoform a [H... 297 3e-80
gi|55749708 outer dense fiber of sperm tails 2-like isoform b [H... 264 3e-70
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 131 2e-30
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 131 2e-30
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 131 2e-30
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 131 2e-30
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 130 4e-30
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 123 8e-28
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 122 2e-27
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 121 3e-27
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 121 3e-27
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 121 3e-27
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 120 4e-27
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 120 4e-27
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 119 1e-26
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 119 1e-26
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 119 1e-26
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 119 1e-26
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 119 1e-26
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 119 1e-26
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 119 1e-26
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 119 1e-26
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 119 1e-26
gi|71061468 centromere protein E [Homo sapiens] 118 2e-26
gi|156104908 myosin heavy chain 6 [Homo sapiens] 118 2e-26
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 117 3e-26
gi|21735548 centrosomal protein 2 [Homo sapiens] 117 6e-26
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 117 6e-26
>gi|24430181 outer dense fiber of sperm tails 2 isoform 1 [Homo
sapiens]
Length = 805
Score = 1553 bits (4020), Expect = 0.0
Identities = 805/805 (100%), Positives = 805/805 (100%)
Query: 1 MKDRSSTPPLHVHVDENTPVHVHIKKLPKPSATSSQKSHKRGMKGDTVNVRRSVRVKTKN 60
MKDRSSTPPLHVHVDENTPVHVHIKKLPKPSATSSQKSHKRGMKGDTVNVRRSVRVKTKN
Sbjct: 1 MKDRSSTPPLHVHVDENTPVHVHIKKLPKPSATSSQKSHKRGMKGDTVNVRRSVRVKTKN 60
Query: 61 PPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQ 120
PPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQ
Sbjct: 61 PPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQ 120
Query: 121 KGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEK 180
KGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEK
Sbjct: 121 KGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEK 180
Query: 181 ECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFE 240
ECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFE
Sbjct: 181 ECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFE 240
Query: 241 ETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQE 300
ETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQE
Sbjct: 241 ETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQE 300
Query: 301 IQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAI 360
IQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAI
Sbjct: 301 IQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAI 360
Query: 361 MEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESW 420
MEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESW
Sbjct: 361 MEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESW 420
Query: 421 RSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAF 480
RSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAF
Sbjct: 421 RSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAF 480
Query: 481 KLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQL 540
KLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQL
Sbjct: 481 KLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQL 540
Query: 541 ERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKN 600
ERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKN
Sbjct: 541 ERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKN 600
Query: 601 IDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFL 660
IDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFL
Sbjct: 601 IDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFL 660
Query: 661 QVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKI 720
QVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKI
Sbjct: 661 QVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKI 720
Query: 721 LDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSSY 780
LDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSSY
Sbjct: 721 LDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSSY 780
Query: 781 ANVFGDGPYSTFLTSSPIRSRSPPA 805
ANVFGDGPYSTFLTSSPIRSRSPPA
Sbjct: 781 ANVFGDGPYSTFLTSSPIRSRSPPA 805
>gi|24430183 outer dense fiber of sperm tails 2 isoform 2 [Homo
sapiens]
Length = 638
Score = 1116 bits (2886), Expect = 0.0
Identities = 580/585 (99%), Positives = 582/585 (99%), Gaps = 1/585 (0%)
Query: 30 PSATSSQKSHKRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDD 89
PS T + KSHKRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDD
Sbjct: 36 PSVTVT-KSHKRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDD 94
Query: 90 DSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETE 149
DSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETE
Sbjct: 95 DSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETE 154
Query: 150 HENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIG 209
HENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIG
Sbjct: 155 HENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIG 214
Query: 210 KLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGAL 269
KLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGAL
Sbjct: 215 KLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGAL 274
Query: 270 LKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQL 329
LKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQL
Sbjct: 275 LKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQL 334
Query: 330 RSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERA 389
RSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERA
Sbjct: 335 RSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERA 394
Query: 390 EKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLV 449
EKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLV
Sbjct: 395 EKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLV 454
Query: 450 NQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLK 509
NQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLK
Sbjct: 455 NQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLK 514
Query: 510 ASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQL 569
ASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQL
Sbjct: 515 ASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQL 574
Query: 570 ADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRI 614
ADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSR+
Sbjct: 575 ADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRV 619
Score = 71.6 bits (174), Expect = 3e-12
Identities = 104/576 (18%), Positives = 230/576 (39%), Gaps = 47/576 (8%)
Query: 210 KLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDS-----ERLME 264
++KT+ C +I + +K + + +LS + HCK + + LM
Sbjct: 60 RVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDDD------SGHCKMNRYDKKIDSLMN 113
Query: 265 QQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGH 324
G L + E+ L+++ +E+EE+ E+ + + + M+ +
Sbjct: 114 AVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDF 173
Query: 325 LQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRA 384
Q + + E L ++ E G +V A+ + + +LK + + R
Sbjct: 174 TILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTR- 232
Query: 385 QKERAEKSEEYAEQLHVQLAD--KDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLN 442
QKE + E+ + L D ++ + E L + + + E + +++L
Sbjct: 233 QKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLL- 291
Query: 443 DRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAH 502
L ++ + +EE ++E + E+ +TA + +E+ R ++ +L
Sbjct: 292 -----LQDKDKEVEELLQEIQ---CEKAQAKTASELSKSMESMR-----GHLQAQLRSKE 338
Query: 503 LEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAAR 562
E +L +KN E + +K++V + + QL+ ++ K+ + K I A +
Sbjct: 339 AENSRLCMQIKNLERSGNQHKAEV-------EAIMEQLKELKQKGDRDKESLKKAIRAQK 391
Query: 563 RQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKL- 621
+ + +QL L + +AE L+ + + + DL I D++
Sbjct: 392 ERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVT 451
Query: 622 EMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKT 681
++ ++ +K + V+ L R+ SA +E E + S +E+K
Sbjct: 452 DLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLE--------NERLKASFAPMEDKL 503
Query: 682 RECGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSR 741
+ +QL++++++ ++ K + A LE K ++ +
Sbjct: 504 NQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEI 563
Query: 742 DDADRRYQSRLQDLK---DRLEQSESTNRSMQNYVQ 774
+ A R++QS+L DL+ D L+ +E+ Q+ +Q
Sbjct: 564 EAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQ 599
>gi|55749696 outer dense fiber of sperm tails 2-like isoform a [Homo
sapiens]
Length = 644
Score = 297 bits (760), Expect = 3e-80
Identities = 186/629 (29%), Positives = 338/629 (53%), Gaps = 9/629 (1%)
Query: 156 RHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEK 215
+ ++ R E + L K+ + EK L + L EAE+ + + KDTI K+ E
Sbjct: 24 KEDLPRCTSESHLSCL-KQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFEN 82
Query: 216 QMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAE 275
++ QKE+L+++L TF+ L LLR++ K+ + L LL+ L +
Sbjct: 83 ANLSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSM---LLENLTD 139
Query: 276 ADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAE 335
+SE L + +K+ ++EL Q EKA A+ S+S++ + LQ Q+ +EAE
Sbjct: 140 NESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAE 199
Query: 336 NSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEY 395
N +L +K+LE + + + +K+ + +LKKA + K+R +
Sbjct: 200 NDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGA 259
Query: 396 AEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTL 455
E+L Q+ D++ ++E +S +W+S Y ++V EK +LE++I + ++ +L+ + +
Sbjct: 260 IEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKM 319
Query: 456 EEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNY 515
E+ + + ++ ++H E LEN +LK + A ++D++ E+ +L+ K
Sbjct: 320 EDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQ 379
Query: 516 EGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQL 575
+ +I+ YK+QV K + A+ V ++ E +N + NK +E R Q +S L +L+++
Sbjct: 380 KTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERV 439
Query: 576 PDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKEN 635
D L E +L ECQ+ LQ + K D I +L+ +++ + L + ++EN
Sbjct: 440 CDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKL-----SLEEEN 494
Query: 636 KQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAI 695
+ LK + L++KLE A+N E + +A +EE + S L+ +EK+ E LARQLE+A+
Sbjct: 495 CLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAAL 554
Query: 696 EDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDL 755
E+ R++V + E S+E A Q KILDLET+L + E +QL + + + L+++
Sbjct: 555 EEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEV 614
Query: 756 KDRLEQSESTNRSMQNYVQFLKSSYANVF 784
++ LE+SE+ N S++NY+QFLK+SY +F
Sbjct: 615 QNSLEKSENQNESIKNYLQFLKTSYVTMF 643
Score = 60.5 bits (145), Expect = 6e-09
Identities = 108/502 (21%), Positives = 196/502 (39%), Gaps = 69/502 (13%)
Query: 10 LHVHVDENTPVHVHIKKLPKPSATSSQKSHKRGMKGDTVNVRRSVRVKT-------KNPP 62
+H EN + ++K L A + +S R K + + ++ + R KT K
Sbjct: 193 IHKREAENDKLKEYVKSLETKIAKWNLQS--RMNKNEAIVMKEASRQKTVALKKASKVYK 250
Query: 63 HCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKG 122
L+ + EKL S +R + + S + +KI + + EV+++
Sbjct: 251 QRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKI-----VIEKTELEVQIETM 305
Query: 123 ERQMA------KRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHL 176
++Q+ K+ + K EE+ ++ E+EN L N+E K + L+ + +
Sbjct: 306 KKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETL--NLENTKLKTTLAALKDEVV 363
Query: 177 QQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKL 236
E E +S+L E E K KT +M T + L E++ +
Sbjct: 364 SVENE--LSELQEVEK-----------------KQKTLIEMYKTQVQKLQEAAEIVKSRC 404
Query: 237 STFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEE 296
N Q K ++ + + +G + L E + R+ L ++ + E
Sbjct: 405 ENLLHKN--------NQITKTKNKNVEKMRGQMESHLKELE----RVCDSLTAAERRLHE 452
Query: 297 LLQEIQCEKA----QAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQ 352
+ +QC K Q T EL ++ H S E EN + ++ +NL++ Q
Sbjct: 453 CQESLQCCKGKCADQEHTIRELQGQVDG--NHNLLTKLSLEEENCLIQLKCENLQQKLEQ 510
Query: 353 HKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAE 412
AE KEL++K +E LK + KE++ + A QL L + VAE
Sbjct: 511 MDAE-------NKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAE 563
Query: 413 ALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHR 472
+E SR + + + DLE E+ N+ LV + + + + L +
Sbjct: 564 ---EIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEK 620
Query: 473 QTAEYSAFKLENERLKASFAPM 494
+ + K + LK S+ M
Sbjct: 621 SENQNESIKNYLQFLKTSYVTM 642
>gi|55749708 outer dense fiber of sperm tails 2-like isoform b [Homo
sapiens]
Length = 513
Score = 264 bits (674), Expect = 3e-70
Identities = 156/516 (30%), Positives = 286/516 (55%), Gaps = 5/516 (0%)
Query: 269 LLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQ 328
LL+ L + +SE L + +K+ ++EL Q EKA A+ S+S++ + LQ Q
Sbjct: 2 LLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQ 61
Query: 329 LRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKER 388
+ +EAEN +L +K+LE + + + +K+ + +LKKA + K+R
Sbjct: 62 IHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQR 121
Query: 389 AEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDL 448
+ E+L Q+ D++ ++E +S +W+S Y ++V EK +LE++I + ++ +L
Sbjct: 122 LDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINL 181
Query: 449 VNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQL 508
+ + +E+ + + ++ ++H E LEN +LK + A ++D++ E+ +L
Sbjct: 182 LEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSEL 241
Query: 509 KASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQ 568
+ K + +I+ YK+QV K + A+ V ++ E +N + NK +E R Q +S
Sbjct: 242 QEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESH 301
Query: 569 LADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKH 628
L +L+++ D L E +L ECQ+ LQ + K D I +L+ +++ + L
Sbjct: 302 LKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKL---- 357
Query: 629 QASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLA 688
+ ++EN + LK + L++KLE A+N E + +A +EE + S L+ +EK+ E LA
Sbjct: 358 -SLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALA 416
Query: 689 RQLESAIEDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRY 748
RQLE+A+E+ R++V + E S+E A Q KILDLET+L + E +QL + +
Sbjct: 417 RQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQ 476
Query: 749 QSRLQDLKDRLEQSESTNRSMQNYVQFLKSSYANVF 784
+ L+++++ LE+SE+ N S++NY+QFLK+SY +F
Sbjct: 477 EVCLKEVQNSLEKSENQNESIKNYLQFLKTSYVTMF 512
Score = 60.5 bits (145), Expect = 6e-09
Identities = 108/502 (21%), Positives = 196/502 (39%), Gaps = 69/502 (13%)
Query: 10 LHVHVDENTPVHVHIKKLPKPSATSSQKSHKRGMKGDTVNVRRSVRVKT-------KNPP 62
+H EN + ++K L A + +S R K + + ++ + R KT K
Sbjct: 62 IHKREAENDKLKEYVKSLETKIAKWNLQS--RMNKNEAIVMKEASRQKTVALKKASKVYK 119
Query: 63 HCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKG 122
L+ + EKL S +R + + S + +KI + + EV+++
Sbjct: 120 QRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKI-----VIEKTELEVQIETM 174
Query: 123 ERQMA------KRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHL 176
++Q+ K+ + K EE+ ++ E+EN L N+E K + L+ + +
Sbjct: 175 KKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETL--NLENTKLKTTLAALKDEVV 232
Query: 177 QQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKL 236
E E +S+L E E K KT +M T + L E++ +
Sbjct: 233 SVENE--LSELQEVEK-----------------KQKTLIEMYKTQVQKLQEAAEIVKSRC 273
Query: 237 STFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEE 296
N Q K ++ + + +G + L E + R+ L ++ + E
Sbjct: 274 ENLLHKN--------NQITKTKNKNVEKMRGQMESHLKELE----RVCDSLTAAERRLHE 321
Query: 297 LLQEIQCEKA----QAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQ 352
+ +QC K Q T EL ++ H S E EN + ++ +NL++ Q
Sbjct: 322 CQESLQCCKGKCADQEHTIRELQGQVDG--NHNLLTKLSLEEENCLIQLKCENLQQKLEQ 379
Query: 353 HKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAE 412
AE KEL++K +E LK + KE++ + A QL L + VAE
Sbjct: 380 MDAE-------NKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAE 432
Query: 413 ALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHR 472
+E SR + + + DLE E+ N+ LV + + + + L +
Sbjct: 433 ---EIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEK 489
Query: 473 QTAEYSAFKLENERLKASFAPM 494
+ + K + LK S+ M
Sbjct: 490 SENQNESIKNYLQFLKTSYVTM 511
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 131 bits (330), Expect = 2e-30
Identities = 146/701 (20%), Positives = 307/701 (43%), Gaps = 53/701 (7%)
Query: 113 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 172
L++E ++ +M R L +K+ELEE+ HE+ E ++ +++ +L
Sbjct: 896 LQAETELYAEAEEMRVR-LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 954
Query: 173 KKHLQQEKECLMSKLVEAEMDGAAAAK----QVMALKDTIGKLKTEKQMTCTDINTLTRQ 228
+ +E+E KL ++ A K +++ + D KL E+++ I+ LT
Sbjct: 955 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014
Query: 229 KELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEAD----------- 277
+K + ++ E + E Q+ LKR E D
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1074
Query: 278 -SEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAEN 336
++ A L + L K++E++ L + E AQ A + + +E LQ L S+ A
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134
Query: 337 SRLCMQIKNLERSGNQHKAEVEAIMEQL---KELKQKGDRDKESLKKAIRAQKERAEKSE 393
++ Q ++L K E+E ++ +EL+ K +++ LKKA+ + E
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1194
Query: 394 EYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVV-KEKGDLELEIIVLNDRVTDLVNQQ 452
+ Q H Q ++ E ++ + Q + KE DL E+ VL ++ +++
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1254
Query: 453 QTLEEKMREDRDSLVERLHRQTAEYS--AFKLENERLKASFAPMEDKLNQAHLEVQQLKA 510
+ LE +++E + + R AE + KL+NE + LN+A + +L
Sbjct: 1255 KKLEAQVQELQSKCSDG-ERARAELNDKVHKLQNE-----VESVTGMLNEAEGKAIKLAK 1308
Query: 511 SVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLA 570
V + + + + + + + V+ +L + ++E L+D++++E+E A++ + ++
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME-AKQNLERHIS 1367
Query: 571 DLQ-QLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQG---DKLEMARE 626
L QL D ++ KL + ++ E I +L + E + DKLE +
Sbjct: 1368 TLNIQLSD----SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1423
Query: 627 KHQASQKE-------NKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEE 679
+ Q + +QL +++ +RK + A E + +K + +++ E
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA---EEKNISSKYADERDRAEAEARE 1480
Query: 680 KTRECGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRR 739
K + +LAR LE A+E A+ ++E+T + +A ++ + + + EL + +R
Sbjct: 1481 KETKALSLARALEEALE-AKEELERTNKML----KAEMEDLVSSKDDVGKNVHELEKSKR 1535
Query: 740 SRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSSY 780
+ + +++L++L+D L+ +E ++ +Q LK +
Sbjct: 1536 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576
Score = 111 bits (278), Expect = 2e-24
Identities = 164/822 (19%), Positives = 340/822 (41%), Gaps = 131/822 (15%)
Query: 2 KDRSSTPPLHVHVDENTPVHVHIKKLPKPSATSSQKSHKRGMKGDTVNVRRSVR-VKTKN 60
K ++ T + H + + V +KK K + + KR ++GD + + ++ +
Sbjct: 1021 KAKNLTKLKNKHESMISELEVRLKKEEK--SRQELEKLKRKLEGDASDFHEQIADLQAQI 1078
Query: 61 PPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQ 120
+++ E ++ RL D + N KKI L + L+ ++ +
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQK--------NNALKKIRELEGHISDLQEDLDSE 1130
Query: 121 KGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEK 180
+ R A++ + EELE + EL +T ++T + + R K E++ T+L KK L +E
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDT-LDSTATQQEL-RAKREQEVTVL-KKALDEET 1187
Query: 181 ECLMSKLVEAEMDGAAA----AKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKL 236
+++ E A A +Q+ K L KQ + L + +L Q
Sbjct: 1188 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1247
Query: 237 STFEETNRTLRDLLREQHCK-EDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVE 295
E + L ++E K D ER + L ++ + +E + +L + + +
Sbjct: 1248 QEVEHKKKKLEAQVQELQSKCSDGER---ARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1304
Query: 296 ELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKA 355
+L +++ +Q + EL + + ++ +LR E E + L Q+ + +
Sbjct: 1305 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1364
Query: 356 EVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALS 415
+ + QL + K+K +D S +A+ K+R +K E Q + + A
Sbjct: 1365 HISTLNIQLSDSKKK-LQDFASTVEALEEGKKRFQKEIENLTQQYEEKA----------- 1412
Query: 416 TLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTA 475
+ Y+++ K K L+ E L+D V DL NQ+Q LV L ++
Sbjct: 1413 ------AAYDKLEKTKNRLQQE---LDDLVVDLDNQRQ------------LVSNLEKKQR 1451
Query: 476 EYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADE 535
++ E + + + +A D+ ++A E ++ + + ++ ++ LEA E
Sbjct: 1452 KFDQLLAEEKNISSKYA---DERDRAEAEAREKETKALSL--------ARALEEALEAKE 1500
Query: 536 VAAQLERCDKENKILKDEMN-------------KEIEAARRQFQSQLADLQQLPDILKIT 582
+LER NK+LK EM E+E ++R ++Q+ ++
Sbjct: 1501 ---ELER---TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM---------- 1544
Query: 583 EAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKV 642
+ +L E +D+LQ E + L + L+ + E + + + ++++ +QL ++
Sbjct: 1545 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERD------LQARDEQNEEKRRQLQRQL 1598
Query: 643 DELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTR---ECGTLARQLESAIEDAR 699
E E +LE Q K E + +L+ + + E R+L++ ++D +
Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658
Query: 700 RQVEQ---TKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDAD----------- 745
R++E +++ + + + K LE L + + +L+ R+R AD
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 746 -------------RRYQSRLQDLKDRLEQSESTNRSMQNYVQ 774
RR ++R+ L++ LE+ + +M + V+
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760
Score = 101 bits (252), Expect = 2e-21
Identities = 156/750 (20%), Positives = 309/750 (41%), Gaps = 134/750 (17%)
Query: 80 RLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELE 139
++ +L ++ D + DK + L N V + + +G+ + + +L+
Sbjct: 1260 QVQELQSKCSDGERARAELNDK-VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318
Query: 140 EVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAK 199
+ L E + + + +++EE++ Q + K+ L + + + + K
Sbjct: 1319 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378
Query: 200 QVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDS 259
++ T+ L+ K+ +I LT+Q E +K + +++ +T L +E
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYE---EKAAAYDKLEKTKNRLQQE------- 1428
Query: 260 ERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSME 319
L + + D+++ +L+ L+ K ++ ++LL E +S
Sbjct: 1429 ---------LDDLVVDLDNQR-QLVSNLEKKQRKFDQLLAE----------EKNISSKYA 1468
Query: 320 SMRGHLQAQLRSKEAENSRLCMQI-------KNLERSGNQHKAEVEAIMEQLKELKQKGD 372
R +A+ R KE + L + + LER+ KAE ME L K
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAE----MEDLVSSKDDVG 1524
Query: 373 RDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKG 432
++ L+K+ RA + + E+ + E+L +L + +A LE + KG
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATE----DAKLRLEV------NMQALKG 1574
Query: 433 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFA 492
E DL + + EEK R+ L RQ EY +LE+ER + + A
Sbjct: 1575 QFE----------RDLQARDEQNEEKRRQ--------LQRQLHEYET-ELEDERKQRALA 1615
Query: 493 PMEDKLNQAHLEVQQLKA------------SVKNYEGMIDNYKSQVMKTRLEADEVAAQL 540
K + L+ +L+A ++ + + +++ ++ R DE+ A
Sbjct: 1616 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1675
Query: 541 ERCDKENKILKD---EMNKEIEAARR--------------QFQSQLADLQQLPDILKITE 583
+ +K+ K L+ ++ +++ AA R + S L+ L D + E
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735
Query: 584 AKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKL--EMAREKHQASQKEN--KQLS 639
A++A+ +++L+ E+ N++ +SD + Q ++L E+A E+ A + E+ +QL
Sbjct: 1736 ARIAQLEEELE-EEQGNME---AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791
Query: 640 LKVDELERKL-EATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLES----- 693
+ EL KL E A +F IA E I Q + ++E++ RE + L+
Sbjct: 1792 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1851
Query: 694 -----AIEDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRY 748
+ED R+ EQ KE A ++ L+ QL + E ++ +R
Sbjct: 1852 KEILLQVEDERKMAEQYKEQA----EKGNARVKQLKRQLEEAEEESQRINANR------- 1900
Query: 749 QSRLQDLKDRLEQSESTNRSMQNYVQFLKS 778
+ L+ L+++ +N +M V LKS
Sbjct: 1901 ----RKLQRELDEATESNEAMGREVNALKS 1926
Score = 100 bits (248), Expect = 7e-21
Identities = 116/580 (20%), Positives = 263/580 (45%), Gaps = 49/580 (8%)
Query: 131 LEERKEELEEVAHELAETEHENTVLRHNIE----RMKEEKDFTILQKKHLQQEKECLMSK 186
LEE K+ ++ L + E +E R+++E D ++ + +Q L K
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Query: 187 LVEAEMDGAAAAKQVMALK--DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNR 244
+ + D A ++ ++ K D + + E + T +L R E L+ E TN+
Sbjct: 1450 --QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1507
Query: 245 TLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCE 304
L K + E L+ + + K + E + K L +++ ++EEL E+Q
Sbjct: 1508 ML---------KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT 1558
Query: 305 KAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQL 364
+ AK E++ M++++G + L++++ +N + + L+R ++++ E+E +Q
Sbjct: 1559 E-DAKLRLEVN--MQALKGQFERDLQARDEQNEE---KRRQLQRQLHEYETELEDERKQ- 1611
Query: 365 KELKQKGDRDKESLKKAIRAQKERAEKSEEYA----EQLHVQLADKDLYVAEALSTLESW 420
+ L + E K + Q + A K E A +L Q+ D + +A ++ +
Sbjct: 1612 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671
Query: 421 RSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAF 480
+ + K+ LE +++ L + DL ++ ++ E ++ L E L + +A
Sbjct: 1672 FATAKENEKKAKSLEADLMQLQE---DLAAAERARKQADLE-KEELAEELASSLSGRNAL 1727
Query: 481 KLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQL 540
+ E RL+A A +E++L + ++ + V+ + +++ R A + +
Sbjct: 1728 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1787
Query: 541 ERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKN 600
++ +++NK L+ ++++ A + +F+S +A L EAK+A+ ++Q++ R+
Sbjct: 1788 QQLERQNKELRSKLHEMEGAVKSKFKSTIAAL----------EAKIAQLEEQVEQEAREK 1837
Query: 601 IDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFL 660
T + +++ ++E R+ + +++ ++ + +V +L+R+LE E
Sbjct: 1838 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE---ESQ 1894
Query: 661 QVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARR 700
++ A R + Q L+E T + R++ + RR
Sbjct: 1895 RINANRRKL----QRELDEATESNEAMGREVNALKSKLRR 1930
Score = 96.7 bits (239), Expect = 8e-20
Identities = 116/590 (19%), Positives = 257/590 (43%), Gaps = 79/590 (13%)
Query: 225 LTRQKELLLQKLSTFEETNRTLRDL------LREQHCK--EDSERLMEQQGALLKRLAEA 276
+TRQ+E + K ++T + L ++H + E+ L EQ A + AEA
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 277 DSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAEN 336
+ + RL Q+ ++ + E+ ++ E+ + + K M L+ QL +EA
Sbjct: 907 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966
Query: 337 SRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYA 396
+L Q++ + K E E ++ + + K ++++ L++ I + EE A
Sbjct: 967 QKL--QLEKVTAEAKIKKLEDEILV--MDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1022
Query: 397 EQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLE 456
+ L + ++E L+ ++ K K LE + ++++ DL Q Q E
Sbjct: 1023 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL--QAQIAE 1080
Query: 457 EKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKL---NQAHLEVQQLKASVK 513
KM+ + E L+A+ A ++D++ N A ++++L+ +
Sbjct: 1081 LKMQ-------------------LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1121
Query: 514 NYEGMIDNYKS----------------QVMKTRLE--ADEVAAQLE---RCDKENKILKD 552
+ + +D+ ++ + +KT LE D A Q E + ++E +LK
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181
Query: 553 EMNKEIEAARRQF----QSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTA--- 605
+++E + Q Q +++L + L+ + A Q E++N DL
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1241
Query: 606 IISDLRSRIEHQGDKLEMAREKHQA----SQKENKQLSLKVDELERKLEATS-------A 654
++ + +EH+ KLE ++ Q+ ++ +L+ KV +L+ ++E+ +
Sbjct: 1242 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1301
Query: 655 QNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSKER 714
+ I+ + +A + +Q L+E+TR+ ++ +L +E+ R ++ + + ++
Sbjct: 1302 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ-LEEERNSLQDQLDEEMEAKQ 1360
Query: 715 AAQNKILDLETQLSRTKTELSQLR---RSRDDADRRYQSRLQDLKDRLEQ 761
+ I L QLS +K +L + ++ +R+Q +++L + E+
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1410
Score = 77.8 bits (190), Expect = 4e-14
Identities = 103/479 (21%), Positives = 201/479 (41%), Gaps = 56/479 (11%)
Query: 95 KMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLE----ERKEELEEVAHELAETEH 150
++ R +K + + M + K +V E + +KR LE E K +LEE+ EL TE
Sbjct: 1501 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1560
Query: 151 ENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLV---EAEMDGAAAAKQVMALKDT 207
L N++ +K + + + + +EK + + + E E++ + + A
Sbjct: 1561 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAA--- 1617
Query: 208 IGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQG 267
K K E + K+L LQ S + ++ L + Q +D +R +E
Sbjct: 1618 -AKKKLEGDL-----------KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1665
Query: 268 ALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTA-SELSKSMESMRGHLQ 326
A + E + K K +E L ++Q + A A+ A + E + L
Sbjct: 1666 ASRDEIFATAKENEK-------KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 327 AQLRSKEA---ENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIR 383
+ L + A E RL +I LE + + +EA+ +++++ Q+ E L +
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA----EQLSNELA 1774
Query: 384 AQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLE-SWRSRYNQVVKEKGDLELEIIVLN 442
++ A+K+E +QL Q +K+L L +E + +S++ + LE +I L
Sbjct: 1775 TERSTAQKNESARQQLERQ--NKEL--RSKLHEMEGAVKSKFKSTIAA---LEAKIAQLE 1827
Query: 443 DRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAH 502
++V ++Q + +++ L E L ++E+ER A +++ + +
Sbjct: 1828 EQVEQEAREKQAATKSLKQKDKKLKEIL---------LQVEDERKMAE--QYKEQAEKGN 1876
Query: 503 LEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAA 561
V+QLK ++ E + K + E DE E +E LK ++ + E +
Sbjct: 1877 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETS 1935
Score = 63.9 bits (154), Expect = 6e-10
Identities = 73/312 (23%), Positives = 136/312 (43%), Gaps = 36/312 (11%)
Query: 118 KMQKGERQMA--KRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKH 175
+++K + QM +R LE+ + +E+ E E + L ++ +++E+ +K
Sbjct: 1646 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1705
Query: 176 LQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTL-------TRQ 228
EKE L +L + A + L+ I +L+ E + ++ + T+Q
Sbjct: 1706 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1765
Query: 229 KELLLQKLSTFEET---NRTLRDLLREQHCKEDSERLMEQQGA----------------- 268
E L +L+T T N + R L Q+ KE +L E +GA
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQN-KELRSKLHEMEGAVKSKFKSTIAALEAKIA 1824
Query: 269 -LLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQA 327
L +++ + EK L+ KDK+++E+L +++ E+ A+ E ++ + L+
Sbjct: 1825 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1884
Query: 328 QLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKE-----SLKKAI 382
QL E E+ R+ + L+R ++ EA+ ++ LK K R E S +
Sbjct: 1885 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGG 1944
Query: 383 RAQKERAEKSEE 394
R E A+ SEE
Sbjct: 1945 RRVIENADGSEE 1956
Score = 49.7 bits (117), Expect = 1e-05
Identities = 47/217 (21%), Positives = 102/217 (47%), Gaps = 18/217 (8%)
Query: 564 QFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEM 623
Q Q ++Q D L+ T+ + + +++L+ E+K+ LT + L+ +++ + +
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 624 AREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEE--KT 681
A E + ++L + E+E +LE + Q + + + Q L LEE +
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRG----QQLQAERKKMAQQMLDLEEQLEE 961
Query: 682 RECGTLARQLESAIEDARRQ-------VEQTKEHALSKER-AAQNKILDLETQLSRTKTE 733
E QLE +A+ + V + + LSKER + +I DL T L+ + +
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 734 LSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQ 770
L + ++ +++S + +L+ RL++ E + + ++
Sbjct: 1022 AKNLTKLKN----KHESMISELEVRLKKEEKSRQELE 1054
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 131 bits (330), Expect = 2e-30
Identities = 146/701 (20%), Positives = 307/701 (43%), Gaps = 53/701 (7%)
Query: 113 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 172
L++E ++ +M R L +K+ELEE+ HE+ E ++ +++ +L
Sbjct: 903 LQAETELYAEAEEMRVR-LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961
Query: 173 KKHLQQEKECLMSKLVEAEMDGAAAAK----QVMALKDTIGKLKTEKQMTCTDINTLTRQ 228
+ +E+E KL ++ A K +++ + D KL E+++ I+ LT
Sbjct: 962 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021
Query: 229 KELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEAD----------- 277
+K + ++ E + E Q+ LKR E D
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1081
Query: 278 -SEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAEN 336
++ A L + L K++E++ L + E AQ A + + +E LQ L S+ A
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141
Query: 337 SRLCMQIKNLERSGNQHKAEVEAIMEQL---KELKQKGDRDKESLKKAIRAQKERAEKSE 393
++ Q ++L K E+E ++ +EL+ K +++ LKKA+ + E
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1201
Query: 394 EYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVV-KEKGDLELEIIVLNDRVTDLVNQQ 452
+ Q H Q ++ E ++ + Q + KE DL E+ VL ++ +++
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1261
Query: 453 QTLEEKMREDRDSLVERLHRQTAEYS--AFKLENERLKASFAPMEDKLNQAHLEVQQLKA 510
+ LE +++E + + R AE + KL+NE + LN+A + +L
Sbjct: 1262 KKLEAQVQELQSKCSDG-ERARAELNDKVHKLQNE-----VESVTGMLNEAEGKAIKLAK 1315
Query: 511 SVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLA 570
V + + + + + + + V+ +L + ++E L+D++++E+E A++ + ++
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME-AKQNLERHIS 1374
Query: 571 DLQ-QLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQG---DKLEMARE 626
L QL D ++ KL + ++ E I +L + E + DKLE +
Sbjct: 1375 TLNIQLSD----SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1430
Query: 627 KHQASQKE-------NKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEE 679
+ Q + +QL +++ +RK + A E + +K + +++ E
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA---EEKNISSKYADERDRAEAEARE 1487
Query: 680 KTRECGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRR 739
K + +LAR LE A+E A+ ++E+T + +A ++ + + + EL + +R
Sbjct: 1488 KETKALSLARALEEALE-AKEELERTNKML----KAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 740 SRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSSY 780
+ + +++L++L+D L+ +E ++ +Q LK +
Sbjct: 1543 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583
Score = 111 bits (278), Expect = 2e-24
Identities = 164/822 (19%), Positives = 340/822 (41%), Gaps = 131/822 (15%)
Query: 2 KDRSSTPPLHVHVDENTPVHVHIKKLPKPSATSSQKSHKRGMKGDTVNVRRSVR-VKTKN 60
K ++ T + H + + V +KK K + + KR ++GD + + ++ +
Sbjct: 1028 KAKNLTKLKNKHESMISELEVRLKKEEK--SRQELEKLKRKLEGDASDFHEQIADLQAQI 1085
Query: 61 PPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQ 120
+++ E ++ RL D + N KKI L + L+ ++ +
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQK--------NNALKKIRELEGHISDLQEDLDSE 1137
Query: 121 KGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEK 180
+ R A++ + EELE + EL +T ++T + + R K E++ T+L KK L +E
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDT-LDSTATQQEL-RAKREQEVTVL-KKALDEET 1194
Query: 181 ECLMSKLVEAEMDGAAA----AKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKL 236
+++ E A A +Q+ K L KQ + L + +L Q
Sbjct: 1195 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1254
Query: 237 STFEETNRTLRDLLREQHCK-EDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVE 295
E + L ++E K D ER + L ++ + +E + +L + + +
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGER---ARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1311
Query: 296 ELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKA 355
+L +++ +Q + EL + + ++ +LR E E + L Q+ + +
Sbjct: 1312 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1371
Query: 356 EVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALS 415
+ + QL + K+K +D S +A+ K+R +K E Q + + A
Sbjct: 1372 HISTLNIQLSDSKKK-LQDFASTVEALEEGKKRFQKEIENLTQQYEEKA----------- 1419
Query: 416 TLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTA 475
+ Y+++ K K L+ E L+D V DL NQ+Q LV L ++
Sbjct: 1420 ------AAYDKLEKTKNRLQQE---LDDLVVDLDNQRQ------------LVSNLEKKQR 1458
Query: 476 EYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADE 535
++ E + + + +A D+ ++A E ++ + + ++ ++ LEA E
Sbjct: 1459 KFDQLLAEEKNISSKYA---DERDRAEAEAREKETKALSL--------ARALEEALEAKE 1507
Query: 536 VAAQLERCDKENKILKDEMN-------------KEIEAARRQFQSQLADLQQLPDILKIT 582
+LER NK+LK EM E+E ++R ++Q+ ++
Sbjct: 1508 ---ELER---TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM---------- 1551
Query: 583 EAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKV 642
+ +L E +D+LQ E + L + L+ + E + + + ++++ +QL ++
Sbjct: 1552 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERD------LQARDEQNEEKRRQLQRQL 1605
Query: 643 DELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTR---ECGTLARQLESAIEDAR 699
E E +LE Q K E + +L+ + + E R+L++ ++D +
Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665
Query: 700 RQVEQ---TKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDAD----------- 745
R++E +++ + + + K LE L + + +L+ R+R AD
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 746 -------------RRYQSRLQDLKDRLEQSESTNRSMQNYVQ 774
RR ++R+ L++ LE+ + +M + V+
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767
Score = 101 bits (252), Expect = 2e-21
Identities = 156/750 (20%), Positives = 309/750 (41%), Gaps = 134/750 (17%)
Query: 80 RLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELE 139
++ +L ++ D + DK + L N V + + +G+ + + +L+
Sbjct: 1267 QVQELQSKCSDGERARAELNDK-VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325
Query: 140 EVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAK 199
+ L E + + + +++EE++ Q + K+ L + + + + K
Sbjct: 1326 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385
Query: 200 QVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDS 259
++ T+ L+ K+ +I LT+Q E +K + +++ +T L +E
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYE---EKAAAYDKLEKTKNRLQQE------- 1435
Query: 260 ERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSME 319
L + + D+++ +L+ L+ K ++ ++LL E +S
Sbjct: 1436 ---------LDDLVVDLDNQR-QLVSNLEKKQRKFDQLLAE----------EKNISSKYA 1475
Query: 320 SMRGHLQAQLRSKEAENSRLCMQI-------KNLERSGNQHKAEVEAIMEQLKELKQKGD 372
R +A+ R KE + L + + LER+ KAE ME L K
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAE----MEDLVSSKDDVG 1531
Query: 373 RDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKG 432
++ L+K+ RA + + E+ + E+L +L + +A LE + KG
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATE----DAKLRLEV------NMQALKG 1581
Query: 433 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFA 492
E DL + + EEK R+ L RQ EY +LE+ER + + A
Sbjct: 1582 QFE----------RDLQARDEQNEEKRRQ--------LQRQLHEYET-ELEDERKQRALA 1622
Query: 493 PMEDKLNQAHLEVQQLKA------------SVKNYEGMIDNYKSQVMKTRLEADEVAAQL 540
K + L+ +L+A ++ + + +++ ++ R DE+ A
Sbjct: 1623 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1682
Query: 541 ERCDKENKILKD---EMNKEIEAARR--------------QFQSQLADLQQLPDILKITE 583
+ +K+ K L+ ++ +++ AA R + S L+ L D + E
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742
Query: 584 AKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKL--EMAREKHQASQKEN--KQLS 639
A++A+ +++L+ E+ N++ +SD + Q ++L E+A E+ A + E+ +QL
Sbjct: 1743 ARIAQLEEELE-EEQGNME---AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798
Query: 640 LKVDELERKL-EATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLES----- 693
+ EL KL E A +F IA E I Q + ++E++ RE + L+
Sbjct: 1799 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1858
Query: 694 -----AIEDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRY 748
+ED R+ EQ KE A ++ L+ QL + E ++ +R
Sbjct: 1859 KEILLQVEDERKMAEQYKEQA----EKGNARVKQLKRQLEEAEEESQRINANR------- 1907
Query: 749 QSRLQDLKDRLEQSESTNRSMQNYVQFLKS 778
+ L+ L+++ +N +M V LKS
Sbjct: 1908 ----RKLQRELDEATESNEAMGREVNALKS 1933
Score = 100 bits (248), Expect = 7e-21
Identities = 116/580 (20%), Positives = 263/580 (45%), Gaps = 49/580 (8%)
Query: 131 LEERKEELEEVAHELAETEHENTVLRHNIE----RMKEEKDFTILQKKHLQQEKECLMSK 186
LEE K+ ++ L + E +E R+++E D ++ + +Q L K
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Query: 187 LVEAEMDGAAAAKQVMALK--DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNR 244
+ + D A ++ ++ K D + + E + T +L R E L+ E TN+
Sbjct: 1457 --QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1514
Query: 245 TLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCE 304
L K + E L+ + + K + E + K L +++ ++EEL E+Q
Sbjct: 1515 ML---------KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT 1565
Query: 305 KAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQL 364
+ AK E++ M++++G + L++++ +N + + L+R ++++ E+E +Q
Sbjct: 1566 E-DAKLRLEVN--MQALKGQFERDLQARDEQNEE---KRRQLQRQLHEYETELEDERKQ- 1618
Query: 365 KELKQKGDRDKESLKKAIRAQKERAEKSEEYA----EQLHVQLADKDLYVAEALSTLESW 420
+ L + E K + Q + A K E A +L Q+ D + +A ++ +
Sbjct: 1619 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Query: 421 RSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAF 480
+ + K+ LE +++ L + DL ++ ++ E ++ L E L + +A
Sbjct: 1679 FATAKENEKKAKSLEADLMQLQE---DLAAAERARKQADLE-KEELAEELASSLSGRNAL 1734
Query: 481 KLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQL 540
+ E RL+A A +E++L + ++ + V+ + +++ R A + +
Sbjct: 1735 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1794
Query: 541 ERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKN 600
++ +++NK L+ ++++ A + +F+S +A L EAK+A+ ++Q++ R+
Sbjct: 1795 QQLERQNKELRSKLHEMEGAVKSKFKSTIAAL----------EAKIAQLEEQVEQEAREK 1844
Query: 601 IDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFL 660
T + +++ ++E R+ + +++ ++ + +V +L+R+LE E
Sbjct: 1845 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE---ESQ 1901
Query: 661 QVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARR 700
++ A R + Q L+E T + R++ + RR
Sbjct: 1902 RINANRRKL----QRELDEATESNEAMGREVNALKSKLRR 1937
Score = 96.7 bits (239), Expect = 8e-20
Identities = 116/590 (19%), Positives = 257/590 (43%), Gaps = 79/590 (13%)
Query: 225 LTRQKELLLQKLSTFEETNRTLRDL------LREQHCK--EDSERLMEQQGALLKRLAEA 276
+TRQ+E + K ++T + L ++H + E+ L EQ A + AEA
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 277 DSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAEN 336
+ + RL Q+ ++ + E+ ++ E+ + + K M L+ QL +EA
Sbjct: 914 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973
Query: 337 SRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYA 396
+L Q++ + K E E ++ + + K ++++ L++ I + EE A
Sbjct: 974 QKL--QLEKVTAEAKIKKLEDEILV--MDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1029
Query: 397 EQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLE 456
+ L + ++E L+ ++ K K LE + ++++ DL Q Q E
Sbjct: 1030 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL--QAQIAE 1087
Query: 457 EKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKL---NQAHLEVQQLKASVK 513
KM+ + E L+A+ A ++D++ N A ++++L+ +
Sbjct: 1088 LKMQ-------------------LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1128
Query: 514 NYEGMIDNYKS----------------QVMKTRLE--ADEVAAQLE---RCDKENKILKD 552
+ + +D+ ++ + +KT LE D A Q E + ++E +LK
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188
Query: 553 EMNKEIEAARRQF----QSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTA--- 605
+++E + Q Q +++L + L+ + A Q E++N DL
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1248
Query: 606 IISDLRSRIEHQGDKLEMAREKHQA----SQKENKQLSLKVDELERKLEATS-------A 654
++ + +EH+ KLE ++ Q+ ++ +L+ KV +L+ ++E+ +
Sbjct: 1249 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1308
Query: 655 QNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSKER 714
+ I+ + +A + +Q L+E+TR+ ++ +L +E+ R ++ + + ++
Sbjct: 1309 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ-LEEERNSLQDQLDEEMEAKQ 1367
Query: 715 AAQNKILDLETQLSRTKTELSQLR---RSRDDADRRYQSRLQDLKDRLEQ 761
+ I L QLS +K +L + ++ +R+Q +++L + E+
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1417
Score = 77.8 bits (190), Expect = 4e-14
Identities = 103/479 (21%), Positives = 201/479 (41%), Gaps = 56/479 (11%)
Query: 95 KMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLE----ERKEELEEVAHELAETEH 150
++ R +K + + M + K +V E + +KR LE E K +LEE+ EL TE
Sbjct: 1508 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1567
Query: 151 ENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLV---EAEMDGAAAAKQVMALKDT 207
L N++ +K + + + + +EK + + + E E++ + + A
Sbjct: 1568 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAA--- 1624
Query: 208 IGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQG 267
K K E + K+L LQ S + ++ L + Q +D +R +E
Sbjct: 1625 -AKKKLEGDL-----------KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1672
Query: 268 ALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTA-SELSKSMESMRGHLQ 326
A + E + K K +E L ++Q + A A+ A + E + L
Sbjct: 1673 ASRDEIFATAKENEK-------KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 327 AQLRSKEA---ENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIR 383
+ L + A E RL +I LE + + +EA+ +++++ Q+ E L +
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA----EQLSNELA 1781
Query: 384 AQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLE-SWRSRYNQVVKEKGDLELEIIVLN 442
++ A+K+E +QL Q +K+L L +E + +S++ + LE +I L
Sbjct: 1782 TERSTAQKNESARQQLERQ--NKEL--RSKLHEMEGAVKSKFKSTIAA---LEAKIAQLE 1834
Query: 443 DRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAH 502
++V ++Q + +++ L E L ++E+ER A +++ + +
Sbjct: 1835 EQVEQEAREKQAATKSLKQKDKKLKEIL---------LQVEDERKMAE--QYKEQAEKGN 1883
Query: 503 LEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAA 561
V+QLK ++ E + K + E DE E +E LK ++ + E +
Sbjct: 1884 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETS 1942
Score = 63.9 bits (154), Expect = 6e-10
Identities = 73/312 (23%), Positives = 136/312 (43%), Gaps = 36/312 (11%)
Query: 118 KMQKGERQMA--KRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKH 175
+++K + QM +R LE+ + +E+ E E + L ++ +++E+ +K
Sbjct: 1653 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1712
Query: 176 LQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTL-------TRQ 228
EKE L +L + A + L+ I +L+ E + ++ + T+Q
Sbjct: 1713 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1772
Query: 229 KELLLQKLSTFEET---NRTLRDLLREQHCKEDSERLMEQQGA----------------- 268
E L +L+T T N + R L Q+ KE +L E +GA
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQN-KELRSKLHEMEGAVKSKFKSTIAALEAKIA 1831
Query: 269 -LLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQA 327
L +++ + EK L+ KDK+++E+L +++ E+ A+ E ++ + L+
Sbjct: 1832 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1891
Query: 328 QLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKE-----SLKKAI 382
QL E E+ R+ + L+R ++ EA+ ++ LK K R E S +
Sbjct: 1892 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGG 1951
Query: 383 RAQKERAEKSEE 394
R E A+ SEE
Sbjct: 1952 RRVIENADGSEE 1963
Score = 49.7 bits (117), Expect = 1e-05
Identities = 47/217 (21%), Positives = 102/217 (47%), Gaps = 18/217 (8%)
Query: 564 QFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEM 623
Q Q ++Q D L+ T+ + + +++L+ E+K+ LT + L+ +++ + +
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 624 AREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEE--KT 681
A E + ++L + E+E +LE + Q + + + Q L LEE +
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRG----QQLQAERKKMAQQMLDLEEQLEE 968
Query: 682 RECGTLARQLESAIEDARRQ-------VEQTKEHALSKER-AAQNKILDLETQLSRTKTE 733
E QLE +A+ + V + + LSKER + +I DL T L+ + +
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 734 LSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQ 770
L + ++ +++S + +L+ RL++ E + + ++
Sbjct: 1029 AKNLTKLKN----KHESMISELEVRLKKEEKSRQELE 1061
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 131 bits (330), Expect = 2e-30
Identities = 146/701 (20%), Positives = 307/701 (43%), Gaps = 53/701 (7%)
Query: 113 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 172
L++E ++ +M R L +K+ELEE+ HE+ E ++ +++ +L
Sbjct: 903 LQAETELYAEAEEMRVR-LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961
Query: 173 KKHLQQEKECLMSKLVEAEMDGAAAAK----QVMALKDTIGKLKTEKQMTCTDINTLTRQ 228
+ +E+E KL ++ A K +++ + D KL E+++ I+ LT
Sbjct: 962 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021
Query: 229 KELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEAD----------- 277
+K + ++ E + E Q+ LKR E D
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1081
Query: 278 -SEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAEN 336
++ A L + L K++E++ L + E AQ A + + +E LQ L S+ A
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141
Query: 337 SRLCMQIKNLERSGNQHKAEVEAIMEQL---KELKQKGDRDKESLKKAIRAQKERAEKSE 393
++ Q ++L K E+E ++ +EL+ K +++ LKKA+ + E
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1201
Query: 394 EYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVV-KEKGDLELEIIVLNDRVTDLVNQQ 452
+ Q H Q ++ E ++ + Q + KE DL E+ VL ++ +++
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1261
Query: 453 QTLEEKMREDRDSLVERLHRQTAEYS--AFKLENERLKASFAPMEDKLNQAHLEVQQLKA 510
+ LE +++E + + R AE + KL+NE + LN+A + +L
Sbjct: 1262 KKLEAQVQELQSKCSDG-ERARAELNDKVHKLQNE-----VESVTGMLNEAEGKAIKLAK 1315
Query: 511 SVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLA 570
V + + + + + + + V+ +L + ++E L+D++++E+E A++ + ++
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME-AKQNLERHIS 1374
Query: 571 DLQ-QLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQG---DKLEMARE 626
L QL D ++ KL + ++ E I +L + E + DKLE +
Sbjct: 1375 TLNIQLSD----SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1430
Query: 627 KHQASQKE-------NKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEE 679
+ Q + +QL +++ +RK + A E + +K + +++ E
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA---EEKNISSKYADERDRAEAEARE 1487
Query: 680 KTRECGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRR 739
K + +LAR LE A+E A+ ++E+T + +A ++ + + + EL + +R
Sbjct: 1488 KETKALSLARALEEALE-AKEELERTNKML----KAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 740 SRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSSY 780
+ + +++L++L+D L+ +E ++ +Q LK +
Sbjct: 1543 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583
Score = 111 bits (278), Expect = 2e-24
Identities = 164/822 (19%), Positives = 340/822 (41%), Gaps = 131/822 (15%)
Query: 2 KDRSSTPPLHVHVDENTPVHVHIKKLPKPSATSSQKSHKRGMKGDTVNVRRSVR-VKTKN 60
K ++ T + H + + V +KK K + + KR ++GD + + ++ +
Sbjct: 1028 KAKNLTKLKNKHESMISELEVRLKKEEK--SRQELEKLKRKLEGDASDFHEQIADLQAQI 1085
Query: 61 PPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQ 120
+++ E ++ RL D + N KKI L + L+ ++ +
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQK--------NNALKKIRELEGHISDLQEDLDSE 1137
Query: 121 KGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEK 180
+ R A++ + EELE + EL +T ++T + + R K E++ T+L KK L +E
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDT-LDSTATQQEL-RAKREQEVTVL-KKALDEET 1194
Query: 181 ECLMSKLVEAEMDGAAA----AKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKL 236
+++ E A A +Q+ K L KQ + L + +L Q
Sbjct: 1195 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1254
Query: 237 STFEETNRTLRDLLREQHCK-EDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVE 295
E + L ++E K D ER + L ++ + +E + +L + + +
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGER---ARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1311
Query: 296 ELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKA 355
+L +++ +Q + EL + + ++ +LR E E + L Q+ + +
Sbjct: 1312 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1371
Query: 356 EVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALS 415
+ + QL + K+K +D S +A+ K+R +K E Q + + A
Sbjct: 1372 HISTLNIQLSDSKKK-LQDFASTVEALEEGKKRFQKEIENLTQQYEEKA----------- 1419
Query: 416 TLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTA 475
+ Y+++ K K L+ E L+D V DL NQ+Q LV L ++
Sbjct: 1420 ------AAYDKLEKTKNRLQQE---LDDLVVDLDNQRQ------------LVSNLEKKQR 1458
Query: 476 EYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADE 535
++ E + + + +A D+ ++A E ++ + + ++ ++ LEA E
Sbjct: 1459 KFDQLLAEEKNISSKYA---DERDRAEAEAREKETKALSL--------ARALEEALEAKE 1507
Query: 536 VAAQLERCDKENKILKDEMN-------------KEIEAARRQFQSQLADLQQLPDILKIT 582
+LER NK+LK EM E+E ++R ++Q+ ++
Sbjct: 1508 ---ELER---TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM---------- 1551
Query: 583 EAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKV 642
+ +L E +D+LQ E + L + L+ + E + + + ++++ +QL ++
Sbjct: 1552 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERD------LQARDEQNEEKRRQLQRQL 1605
Query: 643 DELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTR---ECGTLARQLESAIEDAR 699
E E +LE Q K E + +L+ + + E R+L++ ++D +
Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665
Query: 700 RQVEQ---TKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDAD----------- 745
R++E +++ + + + K LE L + + +L+ R+R AD
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 746 -------------RRYQSRLQDLKDRLEQSESTNRSMQNYVQ 774
RR ++R+ L++ LE+ + +M + V+
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767
Score = 101 bits (252), Expect = 2e-21
Identities = 156/750 (20%), Positives = 309/750 (41%), Gaps = 134/750 (17%)
Query: 80 RLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELE 139
++ +L ++ D + DK + L N V + + +G+ + + +L+
Sbjct: 1267 QVQELQSKCSDGERARAELNDK-VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325
Query: 140 EVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAK 199
+ L E + + + +++EE++ Q + K+ L + + + + K
Sbjct: 1326 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385
Query: 200 QVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDS 259
++ T+ L+ K+ +I LT+Q E +K + +++ +T L +E
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYE---EKAAAYDKLEKTKNRLQQE------- 1435
Query: 260 ERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSME 319
L + + D+++ +L+ L+ K ++ ++LL E +S
Sbjct: 1436 ---------LDDLVVDLDNQR-QLVSNLEKKQRKFDQLLAE----------EKNISSKYA 1475
Query: 320 SMRGHLQAQLRSKEAENSRLCMQI-------KNLERSGNQHKAEVEAIMEQLKELKQKGD 372
R +A+ R KE + L + + LER+ KAE ME L K
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAE----MEDLVSSKDDVG 1531
Query: 373 RDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKG 432
++ L+K+ RA + + E+ + E+L +L + +A LE + KG
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATE----DAKLRLEV------NMQALKG 1581
Query: 433 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFA 492
E DL + + EEK R+ L RQ EY +LE+ER + + A
Sbjct: 1582 QFE----------RDLQARDEQNEEKRRQ--------LQRQLHEYET-ELEDERKQRALA 1622
Query: 493 PMEDKLNQAHLEVQQLKA------------SVKNYEGMIDNYKSQVMKTRLEADEVAAQL 540
K + L+ +L+A ++ + + +++ ++ R DE+ A
Sbjct: 1623 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1682
Query: 541 ERCDKENKILKD---EMNKEIEAARR--------------QFQSQLADLQQLPDILKITE 583
+ +K+ K L+ ++ +++ AA R + S L+ L D + E
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742
Query: 584 AKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKL--EMAREKHQASQKEN--KQLS 639
A++A+ +++L+ E+ N++ +SD + Q ++L E+A E+ A + E+ +QL
Sbjct: 1743 ARIAQLEEELE-EEQGNME---AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798
Query: 640 LKVDELERKL-EATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLES----- 693
+ EL KL E A +F IA E I Q + ++E++ RE + L+
Sbjct: 1799 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1858
Query: 694 -----AIEDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRY 748
+ED R+ EQ KE A ++ L+ QL + E ++ +R
Sbjct: 1859 KEILLQVEDERKMAEQYKEQA----EKGNARVKQLKRQLEEAEEESQRINANR------- 1907
Query: 749 QSRLQDLKDRLEQSESTNRSMQNYVQFLKS 778
+ L+ L+++ +N +M V LKS
Sbjct: 1908 ----RKLQRELDEATESNEAMGREVNALKS 1933
Score = 99.0 bits (245), Expect = 2e-20
Identities = 117/572 (20%), Positives = 258/572 (45%), Gaps = 52/572 (9%)
Query: 131 LEERKEELEEVAHELAETEHENTVLRHNIE----RMKEEKDFTILQKKHLQQEKECLMSK 186
LEE K+ ++ L + E +E R+++E D ++ + +Q L K
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Query: 187 LVEAEMDGAAAAKQVMALK--DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNR 244
+ + D A ++ ++ K D + + E + T +L R E L+ E TN+
Sbjct: 1457 --QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1514
Query: 245 TLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCE 304
L K + E L+ + + K + E + K L +++ ++EEL E+Q
Sbjct: 1515 ML---------KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT 1565
Query: 305 KAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQL 364
+ AK E++ M++++G + L++++ +N + + L+R ++++ E+E +Q
Sbjct: 1566 E-DAKLRLEVN--MQALKGQFERDLQARDEQNEE---KRRQLQRQLHEYETELEDERKQ- 1618
Query: 365 KELKQKGDRDKESLKKAIRAQKERAEKSEEYA----EQLHVQLADKDLYVAEALSTLESW 420
+ L + E K + Q + A K E A +L Q+ D + +A ++ +
Sbjct: 1619 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Query: 421 RSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAF 480
+ + K+ LE +++ L + DL ++ ++ E ++ L E L + +A
Sbjct: 1679 FATAKENEKKAKSLEADLMQLQE---DLAAAERARKQADLE-KEELAEELASSLSGRNAL 1734
Query: 481 KLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQL 540
+ E RL+A A +E++L + ++ + V+ + +++ R A + +
Sbjct: 1735 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1794
Query: 541 ERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKN 600
++ +++NK L+ ++++ A + +F+S +A L EAK+A+ ++Q++ R+
Sbjct: 1795 QQLERQNKELRSKLHEMEGAVKSKFKSTIAAL----------EAKIAQLEEQVEQEAREK 1844
Query: 601 IDLTAIISD----LRSRIEHQGDKLEMAREKHQASQKEN---KQLSLKVDELERKLEATS 653
T + L+ + D+ +MA + + ++K N KQL +++E E + + +
Sbjct: 1845 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1904
Query: 654 AQNIEF---LQVIAKREEAIHQSQLRLEEKTR 682
A + L + EA+ + L+ K R
Sbjct: 1905 ANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 96.7 bits (239), Expect = 8e-20
Identities = 116/590 (19%), Positives = 257/590 (43%), Gaps = 79/590 (13%)
Query: 225 LTRQKELLLQKLSTFEETNRTLRDL------LREQHCK--EDSERLMEQQGALLKRLAEA 276
+TRQ+E + K ++T + L ++H + E+ L EQ A + AEA
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 277 DSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAEN 336
+ + RL Q+ ++ + E+ ++ E+ + + K M L+ QL +EA
Sbjct: 914 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973
Query: 337 SRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYA 396
+L Q++ + K E E ++ + + K ++++ L++ I + EE A
Sbjct: 974 QKL--QLEKVTAEAKIKKLEDEILV--MDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1029
Query: 397 EQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLE 456
+ L + ++E L+ ++ K K LE + ++++ DL Q Q E
Sbjct: 1030 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL--QAQIAE 1087
Query: 457 EKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKL---NQAHLEVQQLKASVK 513
KM+ + E L+A+ A ++D++ N A ++++L+ +
Sbjct: 1088 LKMQ-------------------LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1128
Query: 514 NYEGMIDNYKS----------------QVMKTRLE--ADEVAAQLE---RCDKENKILKD 552
+ + +D+ ++ + +KT LE D A Q E + ++E +LK
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188
Query: 553 EMNKEIEAARRQF----QSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTA--- 605
+++E + Q Q +++L + L+ + A Q E++N DL
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1248
Query: 606 IISDLRSRIEHQGDKLEMAREKHQA----SQKENKQLSLKVDELERKLEATS-------A 654
++ + +EH+ KLE ++ Q+ ++ +L+ KV +L+ ++E+ +
Sbjct: 1249 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1308
Query: 655 QNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSKER 714
+ I+ + +A + +Q L+E+TR+ ++ +L +E+ R ++ + + ++
Sbjct: 1309 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ-LEEERNSLQDQLDEEMEAKQ 1367
Query: 715 AAQNKILDLETQLSRTKTELSQLR---RSRDDADRRYQSRLQDLKDRLEQ 761
+ I L QLS +K +L + ++ +R+Q +++L + E+
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1417
Score = 49.7 bits (117), Expect = 1e-05
Identities = 47/217 (21%), Positives = 102/217 (47%), Gaps = 18/217 (8%)
Query: 564 QFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEM 623
Q Q ++Q D L+ T+ + + +++L+ E+K+ LT + L+ +++ + +
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 624 AREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEE--KT 681
A E + ++L + E+E +LE + Q + + + Q L LEE +
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRG----QQLQAERKKMAQQMLDLEEQLEE 968
Query: 682 RECGTLARQLESAIEDARRQ-------VEQTKEHALSKER-AAQNKILDLETQLSRTKTE 733
E QLE +A+ + V + + LSKER + +I DL T L+ + +
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 734 LSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQ 770
L + ++ +++S + +L+ RL++ E + + ++
Sbjct: 1029 AKNLTKLKN----KHESMISELEVRLKKEEKSRQELE 1061
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 131 bits (330), Expect = 2e-30
Identities = 146/701 (20%), Positives = 307/701 (43%), Gaps = 53/701 (7%)
Query: 113 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 172
L++E ++ +M R L +K+ELEE+ HE+ E ++ +++ +L
Sbjct: 896 LQAETELYAEAEEMRVR-LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 954
Query: 173 KKHLQQEKECLMSKLVEAEMDGAAAAK----QVMALKDTIGKLKTEKQMTCTDINTLTRQ 228
+ +E+E KL ++ A K +++ + D KL E+++ I+ LT
Sbjct: 955 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014
Query: 229 KELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEAD----------- 277
+K + ++ E + E Q+ LKR E D
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1074
Query: 278 -SEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAEN 336
++ A L + L K++E++ L + E AQ A + + +E LQ L S+ A
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134
Query: 337 SRLCMQIKNLERSGNQHKAEVEAIMEQL---KELKQKGDRDKESLKKAIRAQKERAEKSE 393
++ Q ++L K E+E ++ +EL+ K +++ LKKA+ + E
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1194
Query: 394 EYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVV-KEKGDLELEIIVLNDRVTDLVNQQ 452
+ Q H Q ++ E ++ + Q + KE DL E+ VL ++ +++
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1254
Query: 453 QTLEEKMREDRDSLVERLHRQTAEYS--AFKLENERLKASFAPMEDKLNQAHLEVQQLKA 510
+ LE +++E + + R AE + KL+NE + LN+A + +L
Sbjct: 1255 KKLEAQVQELQSKCSDG-ERARAELNDKVHKLQNE-----VESVTGMLNEAEGKAIKLAK 1308
Query: 511 SVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLA 570
V + + + + + + + V+ +L + ++E L+D++++E+E A++ + ++
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME-AKQNLERHIS 1367
Query: 571 DLQ-QLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQG---DKLEMARE 626
L QL D ++ KL + ++ E I +L + E + DKLE +
Sbjct: 1368 TLNIQLSD----SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1423
Query: 627 KHQASQKE-------NKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEE 679
+ Q + +QL +++ +RK + A E + +K + +++ E
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA---EEKNISSKYADERDRAEAEARE 1480
Query: 680 KTRECGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRR 739
K + +LAR LE A+E A+ ++E+T + +A ++ + + + EL + +R
Sbjct: 1481 KETKALSLARALEEALE-AKEELERTNKML----KAEMEDLVSSKDDVGKNVHELEKSKR 1535
Query: 740 SRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSSY 780
+ + +++L++L+D L+ +E ++ +Q LK +
Sbjct: 1536 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576
Score = 111 bits (278), Expect = 2e-24
Identities = 164/822 (19%), Positives = 340/822 (41%), Gaps = 131/822 (15%)
Query: 2 KDRSSTPPLHVHVDENTPVHVHIKKLPKPSATSSQKSHKRGMKGDTVNVRRSVR-VKTKN 60
K ++ T + H + + V +KK K + + KR ++GD + + ++ +
Sbjct: 1021 KAKNLTKLKNKHESMISELEVRLKKEEK--SRQELEKLKRKLEGDASDFHEQIADLQAQI 1078
Query: 61 PPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQ 120
+++ E ++ RL D + N KKI L + L+ ++ +
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQK--------NNALKKIRELEGHISDLQEDLDSE 1130
Query: 121 KGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEK 180
+ R A++ + EELE + EL +T ++T + + R K E++ T+L KK L +E
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDT-LDSTATQQEL-RAKREQEVTVL-KKALDEET 1187
Query: 181 ECLMSKLVEAEMDGAAA----AKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKL 236
+++ E A A +Q+ K L KQ + L + +L Q
Sbjct: 1188 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1247
Query: 237 STFEETNRTLRDLLREQHCK-EDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVE 295
E + L ++E K D ER + L ++ + +E + +L + + +
Sbjct: 1248 QEVEHKKKKLEAQVQELQSKCSDGER---ARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1304
Query: 296 ELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKA 355
+L +++ +Q + EL + + ++ +LR E E + L Q+ + +
Sbjct: 1305 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1364
Query: 356 EVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALS 415
+ + QL + K+K +D S +A+ K+R +K E Q + + A
Sbjct: 1365 HISTLNIQLSDSKKK-LQDFASTVEALEEGKKRFQKEIENLTQQYEEKA----------- 1412
Query: 416 TLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTA 475
+ Y+++ K K L+ E L+D V DL NQ+Q LV L ++
Sbjct: 1413 ------AAYDKLEKTKNRLQQE---LDDLVVDLDNQRQ------------LVSNLEKKQR 1451
Query: 476 EYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADE 535
++ E + + + +A D+ ++A E ++ + + ++ ++ LEA E
Sbjct: 1452 KFDQLLAEEKNISSKYA---DERDRAEAEAREKETKALSL--------ARALEEALEAKE 1500
Query: 536 VAAQLERCDKENKILKDEMN-------------KEIEAARRQFQSQLADLQQLPDILKIT 582
+LER NK+LK EM E+E ++R ++Q+ ++
Sbjct: 1501 ---ELER---TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM---------- 1544
Query: 583 EAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKV 642
+ +L E +D+LQ E + L + L+ + E + + + ++++ +QL ++
Sbjct: 1545 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERD------LQARDEQNEEKRRQLQRQL 1598
Query: 643 DELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTR---ECGTLARQLESAIEDAR 699
E E +LE Q K E + +L+ + + E R+L++ ++D +
Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658
Query: 700 RQVEQ---TKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDAD----------- 745
R++E +++ + + + K LE L + + +L+ R+R AD
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 746 -------------RRYQSRLQDLKDRLEQSESTNRSMQNYVQ 774
RR ++R+ L++ LE+ + +M + V+
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760
Score = 101 bits (252), Expect = 2e-21
Identities = 156/750 (20%), Positives = 309/750 (41%), Gaps = 134/750 (17%)
Query: 80 RLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELE 139
++ +L ++ D + DK + L N V + + +G+ + + +L+
Sbjct: 1260 QVQELQSKCSDGERARAELNDK-VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318
Query: 140 EVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAK 199
+ L E + + + +++EE++ Q + K+ L + + + + K
Sbjct: 1319 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378
Query: 200 QVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDS 259
++ T+ L+ K+ +I LT+Q E +K + +++ +T L +E
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYE---EKAAAYDKLEKTKNRLQQE------- 1428
Query: 260 ERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSME 319
L + + D+++ +L+ L+ K ++ ++LL E +S
Sbjct: 1429 ---------LDDLVVDLDNQR-QLVSNLEKKQRKFDQLLAE----------EKNISSKYA 1468
Query: 320 SMRGHLQAQLRSKEAENSRLCMQI-------KNLERSGNQHKAEVEAIMEQLKELKQKGD 372
R +A+ R KE + L + + LER+ KAE ME L K
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAE----MEDLVSSKDDVG 1524
Query: 373 RDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKG 432
++ L+K+ RA + + E+ + E+L +L + +A LE + KG
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATE----DAKLRLEV------NMQALKG 1574
Query: 433 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFA 492
E DL + + EEK R+ L RQ EY +LE+ER + + A
Sbjct: 1575 QFE----------RDLQARDEQNEEKRRQ--------LQRQLHEYET-ELEDERKQRALA 1615
Query: 493 PMEDKLNQAHLEVQQLKA------------SVKNYEGMIDNYKSQVMKTRLEADEVAAQL 540
K + L+ +L+A ++ + + +++ ++ R DE+ A
Sbjct: 1616 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1675
Query: 541 ERCDKENKILKD---EMNKEIEAARR--------------QFQSQLADLQQLPDILKITE 583
+ +K+ K L+ ++ +++ AA R + S L+ L D + E
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735
Query: 584 AKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKL--EMAREKHQASQKEN--KQLS 639
A++A+ +++L+ E+ N++ +SD + Q ++L E+A E+ A + E+ +QL
Sbjct: 1736 ARIAQLEEELE-EEQGNME---AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791
Query: 640 LKVDELERKL-EATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLES----- 693
+ EL KL E A +F IA E I Q + ++E++ RE + L+
Sbjct: 1792 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1851
Query: 694 -----AIEDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRY 748
+ED R+ EQ KE A ++ L+ QL + E ++ +R
Sbjct: 1852 KEILLQVEDERKMAEQYKEQA----EKGNARVKQLKRQLEEAEEESQRINANR------- 1900
Query: 749 QSRLQDLKDRLEQSESTNRSMQNYVQFLKS 778
+ L+ L+++ +N +M V LKS
Sbjct: 1901 ----RKLQRELDEATESNEAMGREVNALKS 1926
Score = 99.0 bits (245), Expect = 2e-20
Identities = 117/572 (20%), Positives = 258/572 (45%), Gaps = 52/572 (9%)
Query: 131 LEERKEELEEVAHELAETEHENTVLRHNIE----RMKEEKDFTILQKKHLQQEKECLMSK 186
LEE K+ ++ L + E +E R+++E D ++ + +Q L K
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Query: 187 LVEAEMDGAAAAKQVMALK--DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNR 244
+ + D A ++ ++ K D + + E + T +L R E L+ E TN+
Sbjct: 1450 --QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1507
Query: 245 TLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCE 304
L K + E L+ + + K + E + K L +++ ++EEL E+Q
Sbjct: 1508 ML---------KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT 1558
Query: 305 KAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQL 364
+ AK E++ M++++G + L++++ +N + + L+R ++++ E+E +Q
Sbjct: 1559 E-DAKLRLEVN--MQALKGQFERDLQARDEQNEE---KRRQLQRQLHEYETELEDERKQ- 1611
Query: 365 KELKQKGDRDKESLKKAIRAQKERAEKSEEYA----EQLHVQLADKDLYVAEALSTLESW 420
+ L + E K + Q + A K E A +L Q+ D + +A ++ +
Sbjct: 1612 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671
Query: 421 RSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAF 480
+ + K+ LE +++ L + DL ++ ++ E ++ L E L + +A
Sbjct: 1672 FATAKENEKKAKSLEADLMQLQE---DLAAAERARKQADLE-KEELAEELASSLSGRNAL 1727
Query: 481 KLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQL 540
+ E RL+A A +E++L + ++ + V+ + +++ R A + +
Sbjct: 1728 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1787
Query: 541 ERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKN 600
++ +++NK L+ ++++ A + +F+S +A L EAK+A+ ++Q++ R+
Sbjct: 1788 QQLERQNKELRSKLHEMEGAVKSKFKSTIAAL----------EAKIAQLEEQVEQEAREK 1837
Query: 601 IDLTAIISD----LRSRIEHQGDKLEMAREKHQASQKEN---KQLSLKVDELERKLEATS 653
T + L+ + D+ +MA + + ++K N KQL +++E E + + +
Sbjct: 1838 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1897
Query: 654 AQNIEF---LQVIAKREEAIHQSQLRLEEKTR 682
A + L + EA+ + L+ K R
Sbjct: 1898 ANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 96.7 bits (239), Expect = 8e-20
Identities = 116/590 (19%), Positives = 257/590 (43%), Gaps = 79/590 (13%)
Query: 225 LTRQKELLLQKLSTFEETNRTLRDL------LREQHCK--EDSERLMEQQGALLKRLAEA 276
+TRQ+E + K ++T + L ++H + E+ L EQ A + AEA
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 277 DSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAEN 336
+ + RL Q+ ++ + E+ ++ E+ + + K M L+ QL +EA
Sbjct: 907 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966
Query: 337 SRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYA 396
+L Q++ + K E E ++ + + K ++++ L++ I + EE A
Sbjct: 967 QKL--QLEKVTAEAKIKKLEDEILV--MDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1022
Query: 397 EQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLE 456
+ L + ++E L+ ++ K K LE + ++++ DL Q Q E
Sbjct: 1023 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL--QAQIAE 1080
Query: 457 EKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKL---NQAHLEVQQLKASVK 513
KM+ + E L+A+ A ++D++ N A ++++L+ +
Sbjct: 1081 LKMQ-------------------LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1121
Query: 514 NYEGMIDNYKS----------------QVMKTRLE--ADEVAAQLE---RCDKENKILKD 552
+ + +D+ ++ + +KT LE D A Q E + ++E +LK
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181
Query: 553 EMNKEIEAARRQF----QSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTA--- 605
+++E + Q Q +++L + L+ + A Q E++N DL
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1241
Query: 606 IISDLRSRIEHQGDKLEMAREKHQA----SQKENKQLSLKVDELERKLEATS-------A 654
++ + +EH+ KLE ++ Q+ ++ +L+ KV +L+ ++E+ +
Sbjct: 1242 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1301
Query: 655 QNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSKER 714
+ I+ + +A + +Q L+E+TR+ ++ +L +E+ R ++ + + ++
Sbjct: 1302 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ-LEEERNSLQDQLDEEMEAKQ 1360
Query: 715 AAQNKILDLETQLSRTKTELSQLR---RSRDDADRRYQSRLQDLKDRLEQ 761
+ I L QLS +K +L + ++ +R+Q +++L + E+
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1410
Score = 49.7 bits (117), Expect = 1e-05
Identities = 47/217 (21%), Positives = 102/217 (47%), Gaps = 18/217 (8%)
Query: 564 QFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEM 623
Q Q ++Q D L+ T+ + + +++L+ E+K+ LT + L+ +++ + +
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 624 AREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEE--KT 681
A E + ++L + E+E +LE + Q + + + Q L LEE +
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRG----QQLQAERKKMAQQMLDLEEQLEE 961
Query: 682 RECGTLARQLESAIEDARRQ-------VEQTKEHALSKER-AAQNKILDLETQLSRTKTE 733
E QLE +A+ + V + + LSKER + +I DL T L+ + +
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 734 LSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQ 770
L + ++ +++S + +L+ RL++ E + + ++
Sbjct: 1022 AKNLTKLKN----KHESMISELEVRLKKEEKSRQELE 1054
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 130 bits (328), Expect = 4e-30
Identities = 152/720 (21%), Positives = 319/720 (44%), Gaps = 66/720 (9%)
Query: 113 LKSEVKMQKGERQMAKRFLEERKEELEEVAHEL-AETEHENTVLRH----------NIER 161
L++E ++ ++ R L +K+ELEE+ H+L A E E +H NI+
Sbjct: 889 LQAETELCAEAEELRAR-LTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQE 947
Query: 162 MKEEKDFTILQKKHLQQEK---ECLMSKLVEAEM----DGAAAAKQVMALKDTIGKLKTE 214
++E+ + ++ LQ EK E + KL E ++ AK+ L+D I + T
Sbjct: 948 LEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTN 1007
Query: 215 KQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLA 274
+L + K ++ EE R R+ + Q ++ +L L ++A
Sbjct: 1008 LTEEEEKSKSLAKLKNKHEAMITDLEE--RLRREEKQRQELEKTRRKLEGDSTDLSDQIA 1065
Query: 275 EADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEA 334
E ++ A L + L K++E++ L ++ E AQ A + + +ES LQ L S+ A
Sbjct: 1066 ELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERA 1125
Query: 335 ENSRLCMQIKNLERSGNQHKAEVEAIMEQL---KELKQKGDRDKESLKKAIRAQKERAEK 391
++ Q ++L K E+E ++ +EL+ K +++ LKK + + + E
Sbjct: 1126 SRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEA 1185
Query: 392 SEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVK-EKGDLELEIIVLNDRVTDLVN 450
+ Q H Q ++ E +++ + Q ++ E+G+L E+ VL D +
Sbjct: 1186 QIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEH 1245
Query: 451 QQQTLEEKMRE--DRDSLVERLHRQTAE-YSAFKLENERLKASFAPMEDKLNQAHLEVQQ 507
+++ +E +++E + + ER+ + A+ + ++E + + + + K ++ +
Sbjct: 1246 KRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSA 1305
Query: 508 LKASVKNYEGMI--DNYKSQVMKTRLE--ADEVAAQLERCDKENKILKDEMNKEIEAARR 563
L++ +++ + ++ +N + + T+L+ DE + E+ ++E + K + K+I
Sbjct: 1306 LESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEE-AKHNLEKQIATLHA 1364
Query: 564 QFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAI--------------ISD 609
Q ++ L+ E + Q L+G +++ + A + D
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDD 1424
Query: 610 LRSRIEHQGD---KLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKR 666
L ++HQ LE ++K E K +S K E + EA + + +A+
Sbjct: 1425 LLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARA 1484
Query: 667 EEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLETQ 726
E + + LE ++ T L S+ +D + V + ++ +RA + ++ +++TQ
Sbjct: 1485 LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEK----SKRALEQQVEEMKTQ 1540
Query: 727 LSRTKTELSQLRRSRDDADRRYQSRLQ--------DLKDRLEQSESTNRSMQNYVQFLKS 778
L + EL ++ +DA R + LQ DL+ R EQSE + + V+ +++
Sbjct: 1541 LEELEDEL----QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEA 1596
Score = 125 bits (313), Expect = 2e-28
Identities = 157/741 (21%), Positives = 309/741 (41%), Gaps = 102/741 (13%)
Query: 131 LEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEA 190
+ ++EE+ EL + + + + M+ + + +K LQ++ + EA
Sbjct: 840 VSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEA 899
Query: 191 EMDGAAAAKQVMALKDTIGKLKT---EKQMTCTDINTLTRQKELLLQKL-STFEETNRTL 246
E A + L++ L+ E++ C + ++ + +Q+L EE
Sbjct: 900 EELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESAR 959
Query: 247 RDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKA 306
+ L E+ E + +E++ +L+ + + + A+ LL+D+ E L E E+
Sbjct: 960 QKLQLEKVTTEAKLKKLEEEQIILE---DQNCKLAKEKKLLEDRIAEFTTNLTE---EEE 1013
Query: 307 QAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKE 366
++K+ ++L E+M L+ +LR +E + L + LE ++ + Q+ E
Sbjct: 1014 KSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAE 1073
Query: 367 LKQKGDRDKESLKKAI-RAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYN 425
LK + + +E L+ A+ R ++E A+K+ ++ + + ++E LES R+ N
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKNMALK-----KIRELESQISELQEDLESERASRN 1128
Query: 426 QVVKEKGDLELEIIVLNDRVTDLVNQ------------------QQTLEE---------- 457
+ K+K DL E+ L + D ++ ++TLEE
Sbjct: 1129 KAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ 1188
Query: 458 KMREDRDSLVERLHRQTAEYSAFK---------LENER---------LKASFAPMEDKLN 499
+MR+ VE L Q + K LENER L E K
Sbjct: 1189 EMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRK 1248
Query: 500 QAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCD-KENKILKD------ 552
+ ++Q+L+ E + +V K ++E D V L + D K +K+ KD
Sbjct: 1249 KVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALES 1308
Query: 553 ---EMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISD 609
+ + ++ RQ S L+Q+ D +L E ++ E++ L A ++D
Sbjct: 1309 QLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVAD 1368
Query: 610 LRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDE---LERKLEATSAQNIEFLQVIAKR 666
++ ++E LE A E + QK+ + LS + +E KLE T + + L +
Sbjct: 1369 MKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVD 1428
Query: 667 EEAIHQSQLRLEEKTR-------ECGTLARQLESAIEDARRQVEQTKEHALSKERA---A 716
+ QS LE+K + E T++ + + A + + + ALS RA A
Sbjct: 1429 LDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEA 1488
Query: 717 QNKILDLETQLSRTKTELSQLRRSRDDADR-----------------RYQSRLQDLKDRL 759
+ +LE + +TE+ L S+DD + +++L++L+D L
Sbjct: 1489 MEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDEL 1548
Query: 760 EQSESTNRSMQNYVQFLKSSY 780
+ +E ++ +Q +K+ +
Sbjct: 1549 QATEDAKLRLEVNLQAMKAQF 1569
Score = 119 bits (299), Expect = 9e-27
Identities = 157/766 (20%), Positives = 322/766 (42%), Gaps = 102/766 (13%)
Query: 101 KKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIE 160
KKI L + + L+ +++ ++ R A++ + EELE + EL +T ++T + +
Sbjct: 1104 KKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTL-DSTAAQQEL- 1161
Query: 161 RMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAA----AKQVMALKDTIGKLKTEKQ 216
R K E++ IL KK L++E + +++ E + A A+Q+ K L+ KQ
Sbjct: 1162 RSKREQEVNIL-KKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQ 1220
Query: 217 MTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCK-EDSERLMEQQGALLKRL-- 273
+ L + ++LLQ E + + L+E K + ER+ + + +L
Sbjct: 1221 TLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQV 1280
Query: 274 ---------AEADSEKARL---LLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESM 321
+++DS+ ++L L+ + ++ +ELLQE E Q + S K +E
Sbjct: 1281 ELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQE---ENRQKLSLSTKLKQVEDE 1337
Query: 322 RGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVE---AIMEQLKELKQKGDRDKESL 378
+ + QL +E L QI L K ++E +E +E+K+K +D E L
Sbjct: 1338 KNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGL 1397
Query: 379 KKAIRAQKERAEKSEEYAEQLHVQLADK--DL-YVAEALSTLESWRSRYNQVVKEKGDLE 435
+ + +K E+ +L +L D DL + ++ LE + +++Q++ E+ +
Sbjct: 1398 SQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTIS 1457
Query: 436 LEIIVLNDRVTDLVNQQQT--------LEEKMREDRDSLVERLHRQ-TAEYSAFKLENER 486
+ DR +++T LEE M + + +ERL++Q E +
Sbjct: 1458 AKYAEERDRAEAEAREKETKALSLARALEEAMEQKAE--LERLNKQFRTEMEDLMSSKDD 1515
Query: 487 LKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERC--- 543
+ S +E +V+++K ++ E + + ++ + + AQ ER
Sbjct: 1516 VGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQG 1575
Query: 544 ------DKENKILKD--EMNKEIE----------AARRQFQSQLADLQQLPDI------- 578
+K+ ++++ EM E+E AAR++ + L DL+ D
Sbjct: 1576 RDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDE 1635
Query: 579 ----LKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKE 634
L+ +A++ +C +L ++ A + +++ ++ +E+ A+++
Sbjct: 1636 AIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERA 1695
Query: 635 NKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESA 694
+Q + DEL ++ +S + L+ + E I Q + LEE+ + +L+ A
Sbjct: 1696 KRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKA 1755
Query: 695 ---IEDARRQVEQTKEHALSKERAAQN-------------------------KILDLETQ 726
I+ + + HA E A Q I LE +
Sbjct: 1756 NLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAK 1815
Query: 727 LSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQNY 772
+++ + +L + R A ++ + + LKD L Q + R+ + Y
Sbjct: 1816 IAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQY 1861
Score = 105 bits (263), Expect = 1e-22
Identities = 157/768 (20%), Positives = 323/768 (42%), Gaps = 126/768 (16%)
Query: 81 LSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKM---QKGERQMAKRFLEERKEE 137
+ +L+ + + + K N +K +L N G L +EVK+ KG+ + ++ +E +
Sbjct: 1198 VEELAEQLEQTKRVKAN-LEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVE---AQ 1253
Query: 138 LEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAA 197
L+E+ + E E T L + +++ E D L + + SKL + D +A
Sbjct: 1254 LQELQVKFNEGERVRTELADKVTKLQVELD----NVTGLLSQSDSKSSKLTK---DFSAL 1306
Query: 198 AKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQH--- 254
Q+ ++ + + +K T + + +K ++L EE L + H
Sbjct: 1307 ESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQV 1366
Query: 255 ------------CKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDK----DKEVEELL 298
C E +E + + L+ L++ EK L+ +E+++LL
Sbjct: 1367 ADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLL 1426
Query: 299 QEIQCEKAQAKTASELSKSMESM--------------RGHLQAQLRSKEAENSRLCMQIK 344
++ ++ A + K + + R +A+ R KE + L ++
Sbjct: 1427 VDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALE 1486
Query: 345 -------NLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAE 397
LER Q + E ME L K + L+K+ RA +++ E+ + E
Sbjct: 1487 EAMEQKAELERLNKQFRTE----MEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLE 1542
Query: 398 QLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEE 457
+L +L + L++ ++++ + DL+ ++ LV Q + +E
Sbjct: 1543 ELEDELQATEDAKLRLEVNLQAMKAQFER------DLQGRDEQSEEKKKQLVRQVREMEA 1596
Query: 458 KMREDRDSLVERLHRQTAEYSAFKLENE--RLKASFAPMEDKLNQAHLEVQQLKASVKNY 515
++ + ER R A + KLE + L+A ++A ++++L+A +K+
Sbjct: 1597 ELED------ERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDC 1650
Query: 516 EGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEM---NKEIEAARRQFQSQLADL 572
+D+ TR +E+ AQ + +K+ K ++ EM +E+ AA R + +
Sbjct: 1651 MRELDD-------TRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQER 1703
Query: 573 QQLPDIL--------------KITEAKLAECQDQLQ-----------GYERKNIDLTAII 607
+L D + + EA++A+ +++L+ ++ N+ + I
Sbjct: 1704 DELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQIN 1763
Query: 608 SDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQV-IAKR 666
+DL H K E AR Q +++NK+L +K+ E+E +++ +I L+ IA+
Sbjct: 1764 TDLNLERSH-AQKNENAR---QQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQL 1819
Query: 667 EEAIHQSQLRLEEKTRECGTLARQLESA---IEDARRQVEQTKEHALSKERAAQNKILDL 723
EE + + ++ ++L+ ++D RR EQ K+ A A ++ L
Sbjct: 1820 EEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQA----DKASTRLKQL 1875
Query: 724 ETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQN 771
+ QL + E + SR R+ Q ++L+D E +++ NR + +
Sbjct: 1876 KRQLEEAEEEAQRANASR----RKLQ---RELEDATETADAMNREVSS 1916
Score = 74.7 bits (182), Expect = 3e-13
Identities = 97/479 (20%), Positives = 202/479 (42%), Gaps = 66/479 (13%)
Query: 95 KMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLE----ERKEELEEVAHELAETEH 150
++ R +K+ + M + K +V E + +KR LE E K +LEE+ EL TE
Sbjct: 1494 ELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATED 1553
Query: 151 ENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLV---EAEMDG---------AAAA 198
L N++ MK + + + + +EK+ + + V EAE++ AA
Sbjct: 1554 AKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARK 1613
Query: 199 KQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKED 258
K M LKD + + + I L + + + + ++T + ++L + KE+
Sbjct: 1614 KLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQ--AKEN 1671
Query: 259 SERLMEQQGALLKRLAE-ADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKS 317
++L + +++ E A +E+A+ + +E +EL EI + A E
Sbjct: 1672 EKKLKSMEAEMIQLQEELAAAERAK-----RQAQQERDELADEIANSSGKGALALE---- 1722
Query: 318 MESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKES 377
E RL +I LE + + E I ++LK K + +
Sbjct: 1723 -----------------EKRRLEARIAQLEEELEEEQGNTELINDRLK----KANLQIDQ 1761
Query: 378 LKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELE 437
+ + ++ A+K+E +QL Q + + + E T+ +S+Y + LE +
Sbjct: 1762 INTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTV---KSKYKASITA---LEAK 1815
Query: 438 IIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDK 497
I L +++ + ++Q +++R L + L ++++ER A +D+
Sbjct: 1816 IAQLEEQLDNETKERQAACKQVRRTEKKLKDVL---------LQVDDERRNAE--QYKDQ 1864
Query: 498 LNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNK 556
++A ++QLK ++ E + K + E ++ + ++E LK+++ +
Sbjct: 1865 ADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 123 bits (308), Expect = 8e-28
Identities = 152/722 (21%), Positives = 325/722 (45%), Gaps = 72/722 (9%)
Query: 90 DSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQM---AKRFLEERKEELEEVAHELA 146
D +++RY +++ + K+ V+ K + Q+ K LE++ E + +L
Sbjct: 323 DKLESEVSRYKERLHD----IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378
Query: 147 ETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKD 206
E E EN L+ + M+ E+D + +K +++ LM + + EM + + + L
Sbjct: 379 ELEKENLQLKAKLHDMEMERD---MDRKKIEE----LMEENMTLEMAQKQSMDESLHLGW 431
Query: 207 TIGKLKTEKQMTCTDINTLTRQ-KELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQ 265
+ ++ +++ +L + EL +L E N++L + E DS +E
Sbjct: 432 ELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDS---VEG 488
Query: 266 QGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQ-CEKAQAKTASELSKSMESMRGH 324
+ + ++ + + ++ + +L+++ + ++ LQ Q K K ++L K++E++R +
Sbjct: 489 NASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLREN 548
Query: 325 LQAQLRSKEAENSRLCMQIKNL-ERSGNQHKAEVEAI-------MEQLKELKQKGDR--- 373
+ Q++ E EN L + +L +RS +A V+ I E +KE K +
Sbjct: 549 SERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEF 608
Query: 374 DKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGD 433
+K +KK + KE+ E++EE +LH L ++ + + ++ L+ + + +E +
Sbjct: 609 EKRQIKKELEHYKEKGERAEELENELH-HLEKENELLQKKITNLKITCEKIEALEQENSE 667
Query: 434 LELEIIVLN---DRVTDLVNQQQTLE-EKMREDRDSLVERLHRQTAEYSAFKLENERLKA 489
LE E L D +L Q ++LE E + D ++L L R ++ +L+
Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENL--ELRRNVESLKCASMKMAQLQL 725
Query: 490 SFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKI 549
+E + Q ++ LKAS K E + +Y+ +E + LE +K+ +
Sbjct: 726 ENKELESEKEQLKKGLELLKASFKKTERLEVSYQG----LDIENQRLQKTLENSNKKIQQ 781
Query: 550 LKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISD 609
L+ E+ +++E + Q L +L+ L+ E + + + E+ L
Sbjct: 782 LESEL-QDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
Query: 610 LRSRIEHQGDKLEMAREKHQASQKENKQLS----------LKVDELERK-LEATSAQNIE 658
LR + E + LE K +KENK LS +++ ELE++ E I+
Sbjct: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID 900
Query: 659 FLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSKERAAQN 718
++ RE+ + + +L+ ++ + L +LE ++ KE L E++ +
Sbjct: 901 IKTLVTLREDLVSE-KLKTQQMNNDLEKLTHELE--------KIGLNKERLLHDEQSTDD 951
Query: 719 KILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKS 778
+ LE++L T + +++ + ++ L+ RLE+S + N+ ++ ++ +K
Sbjct: 952 RYKLLESKLESTLKKSLEIK----------EEKIAALEARLEESTNYNQQLRQELKTVKK 1001
Query: 779 SY 780
+Y
Sbjct: 1002 NY 1003
Score = 111 bits (277), Expect = 3e-24
Identities = 155/728 (21%), Positives = 309/728 (42%), Gaps = 110/728 (15%)
Query: 113 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 172
LK+++ + ER M ++ +EE EE + ++ E+ L +E++ + +
Sbjct: 387 LKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAP 446
Query: 173 KKHLQQE-KECLMSKLVEAEMDGAAAAKQVMALKDTIG----------KLKTEKQMTCTD 221
+K L E E S+L++ EM+ + K V L+ T+ K++ E Q
Sbjct: 447 QKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKK 506
Query: 222 INTLTRQKELLLQKLSTFEETNRTLRDLLRE--------QHCKEDSER---LMEQQGALL 270
+ L + ++Q+ + + +DL++E + +E+SER ++EQ+ L
Sbjct: 507 VEILENE---IVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL 563
Query: 271 KRLAEADSEKARLLLLLQDKD------------KEVEELLQEIQCEKAQAKTASELSKSM 318
+ + +++++ + KD KE L +I+ EK Q K E K
Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK 623
Query: 319 ESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESL 378
L+ +L E EN L +I NL+ + ++EA+ ++ EL +R+ L
Sbjct: 624 GERAEELENELHHLEKENELLQKKITNLKITCE----KIEALEQENSEL----ERENRKL 675
Query: 379 KKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEI 438
KK + + K + E E+ + QL +++L + + +L+ + Q+ E +LE E
Sbjct: 676 KKTLDSFKNLTFQLES-LEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESE- 733
Query: 439 IVLNDRVTDLVNQQQTLEEKMREDRDSL---VERLHRQTAEYSAFKLENERLKASFAPME 495
+E++++ + L ++ R Y +EN+RL+ +
Sbjct: 734 -----------------KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN 776
Query: 496 DKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAA-QLERCDKENKILKDEM 554
K+ Q E+Q L+ ++Q ++ LE ++++ +LE+ +KENK L+ E
Sbjct: 777 KKIQQLESELQDLE------------MENQTLQKNLEELKISSKRLEQLEKENKSLEQE- 823
Query: 555 NKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRI 614
++E ++Q + + L+Q +I T L E ++ E++N L+ I +
Sbjct: 824 TSQLEKDKKQLEKENKRLRQQAEIKDTT---LEENNVKIGNLEKENKTLSKEIGIYKESC 880
Query: 615 EHQGDKLEMAREKHQASQKENKQL-SLKVDELERKLEATSAQNIEFLQVIAKREEAIHQS 673
+ + +E + + + K L +L+ D + KL+ N L+ + E I +
Sbjct: 881 VRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNN--DLEKLTHELEKIGLN 938
Query: 674 QLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLETQLS---RT 730
+ RL + + LES +E ++ + KE ++ A + + QL +T
Sbjct: 939 KERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 998
Query: 731 KTELSQLRRSRDDADRRYQS--------------------RLQDLKDRLEQSESTNRSMQ 770
+ + + R D +R QS L +KDRL + E N ++Q
Sbjct: 999 VKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQ 1058
Query: 771 NYVQFLKS 778
Q LK+
Sbjct: 1059 AEKQALKT 1066
Score = 104 bits (260), Expect = 3e-22
Identities = 146/688 (21%), Positives = 289/688 (42%), Gaps = 78/688 (11%)
Query: 113 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 172
L E+ K + + ++ LEE+ E+L + EL + E ++
Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQME---------------------IE 287
Query: 173 KKHLQQEKECLMSKLVEAEM--DGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKE 230
K LQQE L+S A M D A ++ D + + + DI + E
Sbjct: 288 LKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVE 347
Query: 231 LLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLK-RLAEADSEKARLLLLLQD 289
L + ET L D L + D +E++ LK +L + + E+ D
Sbjct: 348 ELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMER--------D 399
Query: 290 KD-KEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLER 348
D K++EEL++E + K + + S + + EA L ++ L
Sbjct: 400 MDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNEL-T 458
Query: 349 SGNQHKAEVE--AIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADK 406
S K E+E ++ + ++EL+ D + + K ++ +KE S++ V++ +
Sbjct: 459 SSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKK------VEILEN 512
Query: 407 DLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSL 466
+ + + +L++ ++ ++KEK LE I L + + + E + + SL
Sbjct: 513 E--IVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSL 570
Query: 467 VERLH-RQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQ 525
+R A + EN+ L S KL++ E +Q+K +++Y+
Sbjct: 571 RQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK--------- 621
Query: 526 VMKTRLEADEVAAQLERCDKENKILKDEM-NKEIEAAR-RQFQSQLADLQQLPDILKITE 583
+ A+E+ +L +KEN++L+ ++ N +I + + + ++L++ LK T
Sbjct: 622 --EKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTL 679
Query: 584 AKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVD 643
QL+ E++N L +LR +E L+ A K Q ENK+L + +
Sbjct: 680 DSFKNLTFQLESLEKENSQLDEENLELRRNVE----SLKCASMKMAQLQLENKELESEKE 735
Query: 644 ELERKLEATSA--QNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQ 701
+L++ LE A + E L+V + + +Q RL++ +QLES ++D +
Sbjct: 736 QLKKGLELLKASFKKTERLEVSYQGLDIENQ---RLQKTLENSNKKIQQLESELQDLEME 792
Query: 702 VEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADR-----RYQSRLQDL- 755
QT + L + + + ++ LE + + E SQL + + ++ R Q+ ++D
Sbjct: 793 -NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Query: 756 ----KDRLEQSESTNRSMQNYVQFLKSS 779
++ E N+++ + K S
Sbjct: 852 LEENNVKIGNLEKENKTLSKEIGIYKES 879
Score = 101 bits (251), Expect = 3e-21
Identities = 177/843 (20%), Positives = 337/843 (39%), Gaps = 129/843 (15%)
Query: 29 KPSATSSQKSHKRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTED 88
K S + Q K MK + + +++ +N ++I +E L + S L
Sbjct: 518 KQSLQNCQNLSKDLMK-EKAQLEKTIETLRENSERQIKILEQENEHLNQTV--SSLRQRS 574
Query: 89 DDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLE---ERKEELEEVAHEL 145
S ++ +K+ L ++ S++ + E++ K+ LE E+ E EE+ +EL
Sbjct: 575 QISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENEL 634
Query: 146 AETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALK 205
E EN +L+ I +K T + + L+QE E E + K + + K
Sbjct: 635 HHLEKENELLQKKITNLK----ITCEKIEALEQENS-------ELERENRKLKKTLDSFK 683
Query: 206 DTIGKLKT-EKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLME 264
+ +L++ EK+ + D L ++ + K ++ + L + E KE ++ +E
Sbjct: 684 NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESE-KEQLKKGLE 742
Query: 265 QQGALLKRLAEA-------DSEKARLLLLLQDKDKEVEEL---LQEIQCE---------- 304
A K+ D E RL L++ +K++++L LQ+++ E
Sbjct: 743 LLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEE 802
Query: 305 -KAQAKTASEL---SKSMESMRGHLQAQLRSKEAENSRLCMQ--------------IKNL 346
K +K +L +KS+E L+ + E EN RL Q I NL
Sbjct: 803 LKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNL 862
Query: 347 ERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKA-------------IRAQKERAEKSE 393
E+ E+ E LK+ +KE +K+A + ++K + ++
Sbjct: 863 EKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMN 922
Query: 394 EYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKE-----KGDLEL---EIIVLNDRV 445
E+L +L L L +S RY + + K LE+ +I L R+
Sbjct: 923 NDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARL 982
Query: 446 TDLVNQQQTLEE------------KMREDRDSLVERLHRQTAEYSAFKLENERLKASFAP 493
+ N Q L + K R+D + +V+ + E + ++ E++
Sbjct: 983 EESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLK 1042
Query: 494 MEDKL-----NQAHL--EVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKE 546
++D+L N A L E Q LK +K E +N ++Q++ + + + Q +
Sbjct: 1043 VKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQ 1102
Query: 547 NKILKDEMNKEIEAARRQFQSQLADLQ-QLPDILKITEAKLAECQDQLQGYERKNIDLTA 605
N L+ E N + + +Q A L Q + E+ + E +D Y+ +
Sbjct: 1103 NAKLQVE-NSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYD-------S 1154
Query: 606 IISD---LRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQ--NIEFL 660
+I D L E Q + E KH + +K L ++ +LE + Q +E L
Sbjct: 1155 LIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDL 1214
Query: 661 QVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKI 720
+ + K + Q ++ LE K E T+A + + + R + T L + Q
Sbjct: 1215 EKMLK----VEQEKMLLENKNHE--TVAAEYKKLCGENDR-LNHTYSQLLKETEVLQTDH 1267
Query: 721 LDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSSY 780
+L++ L+ +K E ++L ++ LK++ +Q + T+ + N + L
Sbjct: 1268 KNLKSLLNNSKLEQTRL-----------EAEFSKLKEQYQQLDITSTKLNNQCELLSQLK 1316
Query: 781 ANV 783
N+
Sbjct: 1317 GNL 1319
Score = 91.7 bits (226), Expect = 2e-18
Identities = 135/665 (20%), Positives = 289/665 (43%), Gaps = 79/665 (11%)
Query: 123 ERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKEC 182
E Q ++ LE ++++++ EL + E EN L+ N+E +K + + + L++E +
Sbjct: 764 ENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELK----ISSKRLEQLEKENKS 819
Query: 183 LMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEET 242
L + + E D K+ L+ T + I L ++ + L +++ ++E+
Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKES 879
Query: 243 NRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQ 302
L++L +E KE +R L+ + SEK + + D +K EL ++I
Sbjct: 880 CVRLKELEKEN--KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHEL-EKIG 936
Query: 303 CEKAQA----KTASELSKSMES-MRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEV 357
K + ++ + K +ES + L+ L KE + + L +++ Q + E+
Sbjct: 937 LNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQEL 996
Query: 358 EAIMEQLKELKQKGDRDKE-SLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALST 416
+ + + + LKQ+ D ++ I + + E+ + + +++ D+ + V +T
Sbjct: 997 KTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1056
Query: 417 LES----WRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEE---KMREDRDSLVER 469
L++ +++ Q+ + +L+ +I+ L + L Q TL+ K++ + +L
Sbjct: 1057 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTL--- 1113
Query: 470 LHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKT 529
++ ++ +N +L + +E++ E + LK+ Y+ +I +++ +
Sbjct: 1114 ----NSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSL---YDSLIKDHEKLELLH 1166
Query: 530 RLEADEVAAQLER---CDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKL 586
+A E + + + +K L+ E ++++E Q Q L+ L +LK+ + K+
Sbjct: 1167 ERQASEYESLISKHGTLKSAHKNLEVE-HRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKM 1225
Query: 587 AECQDQLQGYERKNIDLTAI----ISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKV 642
E KN + A + R+ H +L E Q K K L L
Sbjct: 1226 L--------LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSL-LNN 1276
Query: 643 DELER-KLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQ 701
+LE+ +LEA EF +K +E Q + + +C L+ QL+ +E+ R
Sbjct: 1277 SKLEQTRLEA------EF----SKLKEQYQQLDITSTKLNNQCELLS-QLKGNLEEENR- 1324
Query: 702 VEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRD---DADRRYQSRLQDLKDR 758
H L + ++T + + +T L Q S+D R+Y +L +L+ +
Sbjct: 1325 ------HLLDQ----------IQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQ 1368
Query: 759 LEQSE 763
E+ E
Sbjct: 1369 KEKLE 1373
Score = 82.4 bits (202), Expect = 2e-15
Identities = 126/534 (23%), Positives = 228/534 (42%), Gaps = 76/534 (14%)
Query: 256 KEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELS 315
+ED E L++ LKRL + E + ++ L ++ + L AQ+ S
Sbjct: 183 QEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHA--SSSAQSPCGSPGM 240
Query: 316 KSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDK 375
K ES R HL +L +A+ RL +++ K E+E + +LK L+Q
Sbjct: 241 KRTES-RQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQ------ 293
Query: 376 ESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLE 435
E++ A+ R + E L++ R + +V K LE
Sbjct: 294 ENMNLLSDARSARMYRDE-----------------------LDALREKAVRVDK----LE 326
Query: 436 LEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPME 495
E+ +R+ D+ + +EE ++ED L+E T +LE R ++
Sbjct: 327 SEVSRYKERLHDIEFYKARVEE-LKEDNQVLLE-----TKTMLEDQLEGTRARS------ 374
Query: 496 DKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMN 555
DKL++ E QLKA + + E D + ++ E E LE K++ +
Sbjct: 375 DKLHELEKENLQLKAKLHDMEMERDMDRKKIE----ELMEENMTLEMAQKQSMDESLHLG 430
Query: 556 KEIEAARRQFQSQLADLQQL-PDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRI 614
E+E R + A + L ++ ++T ++L + E +N LT + +LR+ +
Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELTSSRLLK-------LEMENQSLTKTVEELRTTV 483
Query: 615 EHQGDKLEMAREKHQASQKENKQLSLKVDELERKL--EATSAQNIEFLQVIAKREEAIHQ 672
D +E K +KEN++LS KV+ LE ++ E S QN + L +E+A +
Sbjct: 484 ----DSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLE 539
Query: 673 SQLRL--EEKTRECGTLARQLE--SAIEDARRQVEQTKEHALSKERAAQNKIL-----DL 723
+ E R+ L ++ E + + RQ Q A K+ +NKIL +
Sbjct: 540 KTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKET 599
Query: 724 ETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLK 777
++LS+ + E Q+++ + + + R ++L++ L E N +Q + LK
Sbjct: 600 SSKLSKIEFEKRQIKKELEHYKEKGE-RAEELENELHHLEKENELLQKKITNLK 652
Score = 41.2 bits (95), Expect = 0.004
Identities = 70/309 (22%), Positives = 121/309 (39%), Gaps = 58/309 (18%)
Query: 27 LPKPSATSSQKSHKRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLST 86
L + + T ++ K ++ T+N +S + +N ++ + +E + DL +
Sbjct: 1092 LQEQNTTLQTQNAKLQVENSTLN-SQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKS 1150
Query: 87 EDDD--SGHCKMN----RYDKKIDSLMNAVGCLKSEVK-----------------MQKGE 123
D H K+ R + +SL++ G LKS K QKG+
Sbjct: 1151 LYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQ 1210
Query: 124 RQMAKRFL--EERKEELEEVAHELAETEH-----ENTVLRHNIERMKEEKDFTILQKKHL 176
+ ++ L E+ K LE HE E+ EN L H ++ +E + +LQ H
Sbjct: 1211 LEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETE--VLQTDHK 1268
Query: 177 QQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKL 236
+ SKL + ++ KLK + Q L Q ELL Q
Sbjct: 1269 NLKSLLNNSKLEQTRLEAE------------FSKLKEQYQQLDITSTKLNNQCELLSQLK 1316
Query: 237 STFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADS----EKARLLLLLQDKDK 292
EE NR L D + + LM Q LL++ E+ E+ + + L + +
Sbjct: 1317 GNLEEENRHLLDQI---------QTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRR 1367
Query: 293 EVEELLQEI 301
+ E+L ++I
Sbjct: 1368 QKEKLEEKI 1376
Score = 35.4 bits (80), Expect = 0.21
Identities = 73/332 (21%), Positives = 127/332 (38%), Gaps = 62/332 (18%)
Query: 116 EVKMQKGERQMAKRFLEERKEELEEVAHEL-----------AETEHENTVLRHNIERMKE 164
EV+ Q K+ L+ + ++LE + L + +NT L+ +++
Sbjct: 1049 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1108
Query: 165 EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIG-------KLKTEKQM 217
E Q L + L+ + E + + K+ LK KL+ +
Sbjct: 1109 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHER 1168
Query: 218 TCTDINTLTRQKELLLQKLSTFEETNRTLRD----LLREQHCKEDSERLM--EQQGALLK 271
++ +L + L E +R L D LL+++ ED E+++ EQ+ LL+
Sbjct: 1169 QASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLE 1228
Query: 272 -------------------RLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTAS 312
RL S+ + +LQ K ++ LL + E Q + +
Sbjct: 1229 NKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE--QTRLEA 1286
Query: 313 ELSKSME--------SMRGHLQAQLRSK-----EAENSRLCMQIKNLERSGNQHKAEVEA 359
E SK E S + + Q +L S+ E EN L QI+ L Q++ +E
Sbjct: 1287 EFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLML---QNRTLLEQ 1343
Query: 360 IMEQLKELKQKGDRDKESLKKAIRAQKERAEK 391
ME K+L R +R QKE+ E+
Sbjct: 1344 NMES-KDLFHVEQRQYIDKLNELRRQKEKLEE 1374
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 122 bits (305), Expect = 2e-27
Identities = 155/773 (20%), Positives = 336/773 (43%), Gaps = 79/773 (10%)
Query: 55 RVKTKNPPHCLEITPPSSE---KLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVG 111
RV TK P L++T E K ++++ + T+ + ++ ++K L+
Sbjct: 836 RVFTKVKP-LLQVTRQEEELQAKDEELLKVKEKQTKVEG----ELEEMERKHQQLLEEKN 890
Query: 112 CLKSEVKMQK---GERQMAKRFLEERKEELEEVAHEL----AETEHENTVLRH------- 157
L +++ + E + + L +K+ELEE+ H+L E E N +L++
Sbjct: 891 ILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQA 950
Query: 158 NIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQM 217
+I+ ++E+ D ++ LQ EK +K+ + E ++++ L+D K EK++
Sbjct: 951 HIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKME-------EEILLLEDQNSKFIKEKKL 1003
Query: 218 ------TCTDINTLTRQKELLLQKLSTFEET------NRTLRDLLREQHCKEDSERLMEQ 265
C+ +K L K+ +E R ++ Q ++ +L +
Sbjct: 1004 MEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGE 1063
Query: 266 QGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHL 325
L ++AE ++ L L L K++E++ L E A ++ + +++ L
Sbjct: 1064 TTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAEL 1123
Query: 326 QAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQL---KELKQKGDRDKESLKKAI 382
Q S++A ++ Q ++L K E+E ++ +EL+ K +++ LKKA+
Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKAL 1183
Query: 383 RAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLN 442
+ + E + Q H ++ ++E L + +++ + K K LE + L
Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEE---LSEQLEQAKRFKA---NLEKNKQGLETDNKELA 1237
Query: 443 DRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLE----NERLKASFAPMEDKL 498
V ++ Q + E R+ D+ V+ LH + +E ++E +L+ + L
Sbjct: 1238 CEV-KVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLL 1296
Query: 499 NQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEI 558
+A + + + E + + + + + + +++++ + ++E L+++ +E
Sbjct: 1297 EEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE- 1355
Query: 559 EAARRQFQSQLADLQ-QLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQ 617
E AR+ + Q+ LQ QL D T+ K+ + ++ E L L R+E +
Sbjct: 1356 EEARKNLEKQVLALQSQLAD----TKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEK 1411
Query: 618 G---DKLEMAREKHQASQKENKQLSLKVD-------ELERKLEATSAQNIEFLQVIAKRE 667
DKLE + + Q+E L++ +D LE+K + E + A+
Sbjct: 1412 ALAYDKLEKTKNR---LQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYA 1468
Query: 668 EAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLETQL 727
E +++ EK + +LAR LE A+E Q K+ RA ++ + +
Sbjct: 1469 EERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQ-----LRADMEDLMSSKDDV 1523
Query: 728 SRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSSY 780
+ EL + +R+ + +++L++L+D L+ +E ++ +Q +K+ +
Sbjct: 1524 GKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQF 1576
Score = 117 bits (294), Expect = 3e-26
Identities = 181/810 (22%), Positives = 342/810 (42%), Gaps = 109/810 (13%)
Query: 33 TSSQKSHKRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSG 92
T++Q+ + + + +++++ +TKN H +I + L +LS + + +
Sbjct: 1162 TAAQQELRTKREQEVAELKKALEEETKN--HEAQIQDMRQRHATA---LEELSEQLEQAK 1216
Query: 93 HCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHEN 152
K N +K L L EVK+ Q K E ++++L+ EL E
Sbjct: 1217 RFKAN-LEKNKQGLETDNKELACEVKVL----QQVKAESEHKRKKLDAQVQELHAKVSEG 1271
Query: 153 TVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLK 212
LR + + LQ E + + + L EAE G AK +L+ +
Sbjct: 1272 DRLRVELAEKASK----------LQNELDNVSTLLEEAEKKGIKFAKDAASLESQL---- 1317
Query: 213 TEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKR 272
Q T + TRQK L ++ EE +L++ E+ +E + L +Q AL +
Sbjct: 1318 ---QDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE--EEARKNLEKQVLALQSQ 1372
Query: 273 LAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSK 332
LA+ + L ++ ++ ++LL++ + + + + +E + LQ +L
Sbjct: 1373 LADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDL 1432
Query: 333 EAENSRLCMQIKNLERSG---NQHKAEVEAIMEQLKELKQKGD---RDKE----SLKKAI 382
+ NLE+ +Q AE ++I + E + + + R+KE SL +A+
Sbjct: 1433 TVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARAL 1492
Query: 383 RAQKERAEKSEEYAEQLHVQLAD----KDLYVAEALSTLESWRSRYNQVVKEKG----DL 434
E E+ E +QL + D KD V + + LE + Q V+E +L
Sbjct: 1493 EEALEAKEEFERQNKQLRADMEDLMSSKD-DVGKNVHELEKSKRALEQQVEEMRTQLEEL 1551
Query: 435 ELEIIVLNDRVTDL-VNQQ----------QTLEEKMREDRDSLVERLHRQTAEYSAFKLE 483
E E+ D L VN Q QT +E+ E + L++++ AE + +
Sbjct: 1552 EDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ 1611
Query: 484 NERLKASFAPMEDKLNQAHLEVQ-------QLKASVKNYEGMIDNYKSQVMKTRLEADEV 536
AS ME L +++ ++ ++ + + +Y+ ++ + R DE+
Sbjct: 1612 RALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEI 1671
Query: 537 AAQLERCDKENKILKDE---MNKEI---EAARR---QFQSQLAD--------LQQLPDIL 579
AQ + +K+ K L+ E + +E+ E ARR Q + +LAD L D
Sbjct: 1672 FAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEK 1731
Query: 580 KITEAKLAECQDQLQGYERKNIDL--------TAIISDLRSRIEHQGDKLEMAREKHQAS 631
+ EA++A+ +++L+ E+ N++L T + L + + + + + Q
Sbjct: 1732 RRLEARIAQLEEELEE-EQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQL 1790
Query: 632 QKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRE---CGTLA 688
+++NK+L K+ ELE A +F I+ E I Q + +LE++ +E L
Sbjct: 1791 ERQNKELKAKLQELE------GAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLV 1844
Query: 689 RQLESAIEDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRY 748
R+ E +++ QVE + HA + +E +R K QL + ++A R
Sbjct: 1845 RRTEKKLKEIFMQVEDERRHADQYKE-------QMEKANARMKQLKRQLEEAEEEATRAN 1897
Query: 749 QSRLQDLKDRLEQSESTNRSMQNYVQFLKS 778
SR + L+ L+ + N + V LK+
Sbjct: 1898 ASR-RKLQRELDDATEANEGLSREVSTLKN 1926
Score = 116 bits (290), Expect = 9e-26
Identities = 148/677 (21%), Positives = 310/677 (45%), Gaps = 65/677 (9%)
Query: 114 KSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQK 173
K EV + E ++ K E+ ++ELE+ +L + E T L+ I ++ + D LQ
Sbjct: 1031 KQEVMISDLEERLKKE--EKTRQELEKAKRKL---DGETTDLQDQIAELQAQIDELKLQL 1085
Query: 174 KHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLL 233
++E + +++ + + A K V L+ I +L+ + + N +QK L
Sbjct: 1086 AKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLS 1145
Query: 234 QKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKE 293
++L E L D L +++ EQ+ A LK+ L+++ K
Sbjct: 1146 EEL---EALKTELEDTLDTTAAQQELRTKREQEVAELKKA-------------LEEETKN 1189
Query: 294 VEELLQEIQCEKAQAKTASELSKSMES---MRGHLQAQLRSKEAENSRLCMQIKNLE--R 348
E +Q+++ A A ELS+ +E + +L+ + E +N L ++K L+ +
Sbjct: 1190 HEAQIQDMRQRHATA--LEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVK 1247
Query: 349 SGNQHKAE-VEAIMEQLKELKQKGDRDKESL-KKAIRAQKERAEKSE--EYAEQLHVQLA 404
+ ++HK + ++A +++L +GDR + L +KA + Q E S E AE+ ++ A
Sbjct: 1248 AESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFA 1307
Query: 405 DKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRD 464
KD A S L+ + + ++K +L I L + L QQ+ EE+ R++ +
Sbjct: 1308 -KD--AASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE-EEEARKNLE 1363
Query: 465 SLVERLHRQTAE-----------YSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVK 513
V L Q A+ + + ++L + +L + L +L+ +
Sbjct: 1364 KQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKN 1423
Query: 514 NYEGMIDNYKSQVMKTRLEADEVAAQLERCDKE-NKILKDEMNKEIEAARRQFQSQLADL 572
+ +D+ + R +VA+ LE+ K+ +++L +E + A + +++
Sbjct: 1424 RLQQELDDLTVDLDHQR----QVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAR 1479
Query: 573 QQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQ 632
++ L + A L E + + +ER+N L A + DL S + G + + +A +
Sbjct: 1480 EKETKALSLARA-LEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALE 1538
Query: 633 KENKQLSLKVDELERKLEATSAQNIEF---LQVI-AKREEAIHQSQLRLEEKTRECGTLA 688
++ +++ +++ELE +L+AT + +Q + A+ E + + EEK R
Sbjct: 1539 QQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQV 1598
Query: 689 RQLESAIEDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRY 748
R+LE+ +ED R+Q + A++ ++ + + DLE Q+ ++ + R+
Sbjct: 1599 RELEAELEDERKQ----RALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQL----RKL 1650
Query: 749 QSRLQDLKDRLEQSEST 765
Q++++D + LE++ ++
Sbjct: 1651 QAQMKDYQRELEEARAS 1667
Score = 106 bits (264), Expect = 1e-22
Identities = 153/663 (23%), Positives = 249/663 (37%), Gaps = 133/663 (20%)
Query: 25 KKLPKPSATSSQKSHKRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDL 84
KKL K + SQ+ ++ + D + KTKN L DL
Sbjct: 1395 KKLLKDAEALSQRLEEKALAYDKLE-------KTKNRLQ---------------QELDDL 1432
Query: 85 STEDDDSGHCKMN--RYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVA 142
+ + D N + KK D L+ E+ ++ R+ EER +
Sbjct: 1433 TVDLDHQRQVASNLEKKQKKFDQLLAE-------------EKSISARYAEER----DRAE 1475
Query: 143 HELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVM 202
E E E + L +E E K+ Q K L+ + E LMS
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSS---------------- 1519
Query: 203 ALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERL 262
KD +GK +++ L + K L Q++ EE L +L E ED++
Sbjct: 1520 --KDDVGK----------NVHELEKSKRALEQQV---EEMRTQLEELEDELQATEDAKLR 1564
Query: 263 MEQQGALLKRLAEAD--------SEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASEL 314
+E +K E D EK RLL+ K+V EL E++ E+ Q A
Sbjct: 1565 LEVNMQAMKAQFERDLQTRDEQNEEKKRLLI------KQVRELEAELEDERKQRALAVAS 1618
Query: 315 SKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRD 374
K ME L+AQ+ + + Q++ L+ ++ E+E E+ +
Sbjct: 1619 KKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKES 1678
Query: 375 KESLK----KAIRAQKERA--EKSEEYAEQLHVQLADKDLYVAEALSTL----ESWRSRY 424
++ LK + ++ Q+E A E++ +AEQ +LAD+ A S L +R
Sbjct: 1679 EKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARI 1738
Query: 425 NQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDR------DSLVERLHRQTAEYS 478
Q+ +E + + + +LNDR Q TL ++ +R D+ ++L RQ E
Sbjct: 1739 AQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELK 1798
Query: 479 A------------FKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQV 526
A FK L+A +E++L Q E V+ E + QV
Sbjct: 1799 AKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQV 1858
Query: 527 MKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKL 586
R AD+ Q+E+ + K LK ++ + E A R A
Sbjct: 1859 EDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATR------------------ANASR 1900
Query: 587 AECQDQLQGYERKNIDLTAIISDLRSRIEHQGD-KLEMAREKHQASQKENKQLSLKVDEL 645
+ Q +L N L+ +S L++R+ G +R + E L L D+
Sbjct: 1901 RKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDT 1960
Query: 646 ERK 648
E K
Sbjct: 1961 ESK 1963
Score = 102 bits (253), Expect = 2e-21
Identities = 114/532 (21%), Positives = 245/532 (46%), Gaps = 51/532 (9%)
Query: 286 LLQDKDKEVEELLQEIQC-------EKAQAKTASELSKSMESMRGHLQAQLRSKEAENSR 338
L +++D ++ +++ Q KA AK +LS +++ ++ + A L+ + + R
Sbjct: 778 LEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLS-ALKVLQRNCAAYLKLRHWQWWR 836
Query: 339 LCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQ 398
+ ++K L + Q + E++A E+L ++K+K + + L++ R ++ E+ AEQ
Sbjct: 837 VFTKVKPLLQVTRQEE-ELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQ 895
Query: 399 LHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLE-- 456
L + E + E R+R + +K +LE + L RV + + Q L+
Sbjct: 896 LQAE--------TELFAEAEEMRAR---LAAKKQELEEILHDLESRVEEEEERNQILQNE 944
Query: 457 -EKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNY 515
+KM+ L E+L + +LE +A ME+++ + + K
Sbjct: 945 KKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLM 1004
Query: 516 EGMIDNYKSQVMKTRLEADEVAA-----QLERCDKENKILKDEMNK-EIEAARRQF---- 565
E I SQ+ + +A +A ++ D E ++ K+E + E+E A+R+
Sbjct: 1005 EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGET 1064
Query: 566 ---QSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTA-------IISDLRSRIE 615
Q Q+A+LQ D LK+ +LA+ +++LQG + D T ++ +L+++I
Sbjct: 1065 TDLQDQIAELQAQIDELKL---QLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIA 1121
Query: 616 HQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQL 675
+ E + ++K+ + LS +++ L+ +LE T ++ KRE+ + + +
Sbjct: 1122 ELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKK 1181
Query: 676 RLEEKTR----ECGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLETQLSRTK 731
LEE+T+ + + ++ +A+E+ Q+EQ K + E+ Q D + K
Sbjct: 1182 ALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVK 1241
Query: 732 TELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSSYANV 783
L Q++ + ++ +++Q+L ++ + + + L++ NV
Sbjct: 1242 V-LQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNV 1292
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 121 bits (303), Expect = 3e-27
Identities = 160/744 (21%), Positives = 319/744 (42%), Gaps = 84/744 (11%)
Query: 97 NRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTV-L 155
++ KK+ L + L+ E++ ++ R ++ + ELEE++ L E +V +
Sbjct: 1102 SQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQI 1161
Query: 156 RHNIERMKE-EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTE 214
N +R E +K L++ LQ E + A+ A +Q+ L+ KL+ E
Sbjct: 1162 EMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHAD-SVAELGEQIDNLQRVKQKLEKE 1220
Query: 215 KQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCK-EDSER-----------L 262
K +++ +T E +++ + E+ RTL D + E K E+++R L
Sbjct: 1221 KSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKL 1280
Query: 263 MEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMR 322
+ G L ++L E ++ ++L +++E+L ++++ E+ +AK A L+ +++S R
Sbjct: 1281 QTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLE-EEVKAKNA--LAHALQSAR 1337
Query: 323 GHLQAQLRSKEAENSRLCMQIKNLERSGNQH------KAEVEAIM--EQLKELKQKGDRD 374
H LR + E + +++ + N K E +AI E+L+E K+K +
Sbjct: 1338 -HDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1396
Query: 375 KESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYV------AEALST--------LESW 420
+ ++A+ A + E+ +L ++ D + V A AL L W
Sbjct: 1397 LQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEW 1456
Query: 421 RSRYNQVV-------KEKGDLELEIIVLNDRVTDLVNQQQTLEEK---MREDRDSLVERL 470
+ +Y + KE L E+ L + + + +T + + ++E+ L E+L
Sbjct: 1457 KQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQL 1516
Query: 471 H------------RQTAEYSAFKLEN--ERLKASFAPMEDKLNQAHLEVQQLKASVKNYE 516
R+ E +L++ E +AS E K+ +A LE Q+KA ++
Sbjct: 1517 GSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKL 1576
Query: 517 GMIDNYKSQVMKTRLEA-DEVAAQLE-RCDKENKILKDEMNKEIEAARRQFQSQLADLQQ 574
D Q + L D + L+ N+ L+ + K++E + + QL+ +
Sbjct: 1577 AEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALR--VKKKMEGDLNEMEIQLSHANR 1634
Query: 575 LP----DILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQA 630
+ +K ++ L + Q QL R N DL I+ + R +LE R +
Sbjct: 1635 MAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQ 1694
Query: 631 SQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQ 690
+++ K ++ E +++ +QN + K + + Q Q +EE +EC +
Sbjct: 1695 TERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEK 1754
Query: 691 LESAIEDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQS 750
+ AI DA E+ K+ Q+ LE + + L+ D+A+ Q
Sbjct: 1755 AKKAITDAAMMAEELKKE--------QDTSAHLERMKKNMEQTIKDLQHRLDEAE---QI 1803
Query: 751 RLQDLKDRLEQSESTNRSMQNYVQ 774
L+ K +L++ E+ R ++N ++
Sbjct: 1804 ALKGGKKQLQKLEARVRELENELE 1827
Score = 114 bits (286), Expect = 3e-25
Identities = 153/732 (20%), Positives = 326/732 (44%), Gaps = 92/732 (12%)
Query: 73 EKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLE 132
EK+VS+++ E +D D D+ +K++++++ ++M +R LE
Sbjct: 875 EKMVSLLQ------EKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNER-LE 927
Query: 133 ERKEELEEVAHELAETEHENTVLRHNIE-------RMKEEKDFTILQKKHLQQEKECLMS 185
+ +E E+ + + E E + L+ +I+ ++++EK T + K+L +E L
Sbjct: 928 DEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDE 987
Query: 186 KLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKL----STFEE 241
+ A K+ AL++ + + Q +NTLT+ K L Q++ + E+
Sbjct: 988 II-------AKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQ 1040
Query: 242 TNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEI 301
+ DL R + E +L ++ + + +++K +L L+ KD E+ L I
Sbjct: 1041 EKKVRMDLERAKRKLEGDLKLTQES------IMDLENDKQQLDERLKKKDFELNALNARI 1094
Query: 302 QCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIM 361
+ E+A S+L K ++ ++ ++ EAE + +E+ + E+E I
Sbjct: 1095 EDEQA---LGSQLQKKLKELQARIEELEEELEAERTARA----KVEKLRSDLSRELEEIS 1147
Query: 362 EQLKE--------LKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEA 413
E+L+E ++ R+ E +K R +E + E A L + AD + E
Sbjct: 1148 ERLEEAGGATSVQIEMNKKREAE-FQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQ 1206
Query: 414 LSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQ 473
+ L+ + + + KEK + +LE+ + + ++ + LE+ R D + E HR
Sbjct: 1207 IDNLQRVKQK---LEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNE--HRS 1261
Query: 474 TAEYSAFKL-----ENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMK 528
AE + + + +L+ + +L++ + QL Y +++ K Q+ +
Sbjct: 1262 KAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEE 1321
Query: 529 TRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAE 588
+ +A L+ + +L+++ +E EA A+LQ+ +L +++A+
Sbjct: 1322 EVKAKNALAHALQSARHDCDLLREQYEEETEAK--------AELQR---VLSKANSEVAQ 1370
Query: 589 CQDQLQGYERKNIDLTAIISD----LRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDE 644
+ + YE I T + + L R++ + +E K + +K +L ++++
Sbjct: 1371 WRTK---YETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIED 1427
Query: 645 LERKLEATSA-------QNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQ---LESA 694
L +E ++A + F +++A+ ++ +SQ LE +E +L+ + L++A
Sbjct: 1428 LMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNA 1487
Query: 695 IEDARRQVEQTKEHALSKERAAQNKILDLETQL---SRTKTELSQLRRSRDDADRRYQSR 751
E++ +E K + + Q +I DL QL +T EL ++R+ + QS
Sbjct: 1488 YEESLEHLETFKR----ENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSA 1543
Query: 752 LQDLKDRLEQSE 763
L++ + LE E
Sbjct: 1544 LEEAEASLEHEE 1555
Score = 103 bits (256), Expect = 8e-22
Identities = 153/742 (20%), Positives = 311/742 (41%), Gaps = 93/742 (12%)
Query: 47 TVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSL 106
T N+ + ++ K C + +E S + S D S K+ + ++
Sbjct: 1232 TSNMEQIIKAKANLEKMCRTLEDQMNEHR-SKAEETQRSVNDLTSQRAKLQTENGELSRQ 1290
Query: 107 MNAVGCLKSEVKMQK----GERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIE-- 160
++ L S++ K + + KR LEE + +AH L H+ +LR E
Sbjct: 1291 LDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEE 1350
Query: 161 ---------------------RMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAK 199
R K E D I + + L++ K+ L +L EAE A
Sbjct: 1351 TEAKAELQRVLSKANSEVAQWRTKYETD-AIQRTEELEEAKKKLAQRLQEAEEAVEAVNA 1409
Query: 200 QVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCK-ED 258
+ +L+ T +L+ E + D+ L +K F++ + E + E
Sbjct: 1410 KCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELES 1469
Query: 259 SERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQA-KTASELSK- 316
S++ L +L A E L + ++K ++E + ++ + + KT EL K
Sbjct: 1470 SQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKV 1529
Query: 317 --SMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRD 374
+E+ + LQ+ L EA +I + NQ KAE+E
Sbjct: 1530 RKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE---------------- 1573
Query: 375 KESLKKAIRAQKERAEKSEEY--AEQLHVQLAD--KDLYVAEALSTLESWRSRYNQVVKE 430
++ AEK EE A++ H+++ D + AE S E+ R + ++ +
Sbjct: 1574 -----------RKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK-KKMEGD 1621
Query: 431 KGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKAS 490
++E+++ N + Q ++L+ +++ + L + + N+ LK +
Sbjct: 1622 LNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRA-----------NDDLKEN 1670
Query: 491 FAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKIL 550
A +E + N E+++L+A V+ E + ++++T + +Q + K +
Sbjct: 1671 IAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKM 1730
Query: 551 KDEMNK---EIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAII 607
++++ E+E A ++ ++ ++ + +L + QD ER ++ I
Sbjct: 1731 DADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTI 1790
Query: 608 SDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKRE 667
DL+ R++ E + + +K+ ++L +V ELE +LEA +N E ++ + K E
Sbjct: 1791 KDLQHRLD------EAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSE 1844
Query: 668 EAIHQSQLRLEEKTR---ECGTLARQLESAIEDARRQVEQTKEHA---LSKERAAQNKIL 721
I + + EE + L +L+ ++ +RQ E+ +E A LSK R Q+++
Sbjct: 1845 RRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELD 1904
Query: 722 DLETQLSRTKTELSQLR-RSRD 742
+ E + ++++++LR +SRD
Sbjct: 1905 EAEERADIAESQVNKLRAKSRD 1926
Score = 99.8 bits (247), Expect = 9e-21
Identities = 113/532 (21%), Positives = 235/532 (44%), Gaps = 57/532 (10%)
Query: 280 KARLLLLLQD-KDKEVEELLQEIQCEKAQAKTASELSKSMES------MRGHLQAQLRSK 332
KA LL LL++ +D+ + ++ IQ + E K +E ++ +++A + K
Sbjct: 766 KAGLLGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVK 825
Query: 333 EAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKS 392
+L +IK L +S + K ++ +K++ R KE+L+K+ +KE EK
Sbjct: 826 NWPWMKLYFKIKPLLKSAEREK--------EMASMKEEFTRLKEALEKSEARRKELEEKM 877
Query: 393 EEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTD----- 447
++ + D L V L R +Q++K K LE ++ +N+R+ D
Sbjct: 878 VSLLQEKN----DLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMN 933
Query: 448 --LVNQQQTLEEK---MREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMED------ 496
L +++ LE++ ++ D D L L + E A + + + L A +++
Sbjct: 934 AELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLT 993
Query: 497 ----KLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKD 552
L +AH QQ ++ E ++ +K + D++ LE+ +K+ ++ +
Sbjct: 994 KEKKALQEAH---QQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQ-EKKVRMDLE 1049
Query: 553 EMNKEIEAARRQFQSQLADL----QQLPDILKITEAKLAECQDQLQGYERKNIDLTAIIS 608
+++E + Q + DL QQL + LK + +L +++ + L +
Sbjct: 1050 RAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLK 1109
Query: 609 DLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREE 668
+L++RIE ++LE R +K LS +++E+ +LE +++ KRE
Sbjct: 1110 ELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREA 1169
Query: 669 AIHQSQLRLEEKTRE----CGTLARQLESAIEDARRQVE--QTKEHALSKERAAQNKILD 722
+ + LEE T + L ++ ++ + Q++ Q + L KE++ LD
Sbjct: 1170 EFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELD 1229
Query: 723 LET----QLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQ 770
T Q+ + K L ++ R+ +D ++S+ ++ + + S +Q
Sbjct: 1230 DVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQ 1281
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 121 bits (303), Expect = 3e-27
Identities = 158/724 (21%), Positives = 322/724 (44%), Gaps = 83/724 (11%)
Query: 98 RYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRH 157
++ KKI L + L+ E++ ++ R ++ + ELEE++ L E V
Sbjct: 1104 QFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEA---GGVTST 1160
Query: 158 NIERMKEEKDFTILQKKHLQQ---EKECLMSKLVEAEMDGAAA-AKQVMALKDTIGKLKT 213
IE K+ + + ++ L++ + E +++ L + D A +Q+ L+ KL+
Sbjct: 1161 QIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEK 1220
Query: 214 EKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDS------------ER 261
EK +I+ L+ E + + + E+ RTL D L E K + R
Sbjct: 1221 EKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSR 1280
Query: 262 LMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESM 321
L + G L ++L E +S ++L Q ++ EEL ++++ E+ +AK A L+ +++S
Sbjct: 1281 LQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLE-EENKAKNA--LAHALQSS 1337
Query: 322 RGH---LQAQLRSKEAENSRL--CMQIKNLERSGNQHKAEVEAIM--EQLKELKQKGDR- 373
R L+ Q ++ + L + N E + + K E +AI E+L+E K+K +
Sbjct: 1338 RHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1397
Query: 374 --DKESLKKAIRAQKERAEKSE--------------EYAEQLHVQLADK----DLYVAEA 413
D E +A+ A+ EK++ E A L L K D +AE
Sbjct: 1398 LQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEW 1457
Query: 414 LSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQ 473
+ E ++ +KE L E+ L + + ++Q +T++ RE+++ L ++
Sbjct: 1458 KTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVK---RENKN-----LEQE 1509
Query: 474 TAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEA 533
A+ + EN + + +E Q LE ++ +++ E +++ ++++++ +LE
Sbjct: 1510 IADLTEQIAENGK---TIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLEL 1566
Query: 534 DEVAAQLERC----DKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAEC 589
+V ++++R D+E + LK + +E + +++ + + K E L E
Sbjct: 1567 TQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEI 1626
Query: 590 QDQLQGYERKNID----LTAIISDLRSRIEHQGDKL---EMAREKHQASQKENKQLSLKV 642
+ QL R+ + L ++ L+ H D L E +E+ ++ L +V
Sbjct: 1627 EIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEV 1686
Query: 643 DELERKLEATS-AQNIEFLQVIAKRE--EAIHQSQLRLEEKTRECGTLARQLESAIEDAR 699
+EL LE T A+ + +++ E + +H L ++ T QL+S +EDA
Sbjct: 1687 EELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDAS 1746
Query: 700 RQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRL 759
R +E K + A + +L + + + L R + + + ++DL+ RL
Sbjct: 1747 RDARNAEE----KAKKAITDAAMMAEELKKEQDTSAHLERMK----KNLEQTVKDLQHRL 1798
Query: 760 EQSE 763
+++E
Sbjct: 1799 DEAE 1802
Score = 105 bits (263), Expect = 1e-22
Identities = 162/744 (21%), Positives = 317/744 (42%), Gaps = 122/744 (16%)
Query: 113 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 172
+K +K + E++MA KEE ++ ELA++E + L EEK T++Q
Sbjct: 837 IKPLLKSAETEKEMATM-----KEEFQKTKDELAKSEAKRKEL--------EEKLVTLVQ 883
Query: 173 KKH-LQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINT-LTRQKE 230
+K+ LQ + + L++AE K L+ I K TE+ +IN LT +K
Sbjct: 884 EKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKI-KEVTERAEDEEEINAELTAKKR 942
Query: 231 LLLQKLS----TFEETNRTLRDLLREQHCKEDS-ERLMEQQGALLKRLAEADSEKARL-- 283
L + S ++ TL + +E+H E+ + L E+ L + +A+ EK L
Sbjct: 943 KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQE 1002
Query: 284 --------LLLLQDK-----------DKEVEELLQEIQCEK--------------AQAKT 310
L +DK +++VE+L ++ EK K
Sbjct: 1003 AHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKL 1062
Query: 311 ASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQK 370
A E +E+ + L +L+ K+ E +L ++++ + G Q + +++ + +++EL+++
Sbjct: 1063 AQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEE 1122
Query: 371 GDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALST-LESWRSRYNQVVK 429
+ ++ + K + + + A + EE +E+L ST +E + R + +K
Sbjct: 1123 IEAERATRAKTEKQRSDYARELEELSERLE--------EAGGVTSTQIELNKKREAEFLK 1174
Query: 430 EKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKA 489
+ DLE + V L + ++ E D+L + E S FKLE + L +
Sbjct: 1175 LRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSS 1234
Query: 490 SF--------------APMEDKLNQA---HLEVQQLKASVKNYEGMIDNYKSQVMKTRLE 532
S +ED+L++A + E+Q+ + + + + ++ + E
Sbjct: 1235 SMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEE 1294
Query: 533 ADEVAAQLERC-------DKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAK 585
+ + +QL R +E K +E NK A QS D L + + +
Sbjct: 1295 KESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEG 1354
Query: 586 LAECQDQLQ-----------GYERKNIDLTAIISD----LRSRIEHQGDKLEMAREKHQA 630
AE Q L YE I T + + L R++ +++E K +
Sbjct: 1355 KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCAS 1414
Query: 631 SQKENKQLSLKVDELERKLE-------ATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRE 683
+K ++L +V++L +E A + F +V+A+ + +SQ LE +E
Sbjct: 1415 LEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKE 1474
Query: 684 CGTLARQ---LESAIEDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRS 740
+L+ + L++A E+A Q+E K + + + +I DL Q++ + +L +S
Sbjct: 1475 SRSLSTELFKLKNAYEEALDQLETVKR----ENKNLEQEIADLTEQIAENGKTIHELEKS 1530
Query: 741 RDDADRRYQSRLQDLKDRLEQSES 764
R ++ + D++ LE++E+
Sbjct: 1531 R----KQIELEKADIQLALEEAEA 1550
Score = 104 bits (259), Expect = 4e-22
Identities = 159/743 (21%), Positives = 320/743 (43%), Gaps = 105/743 (14%)
Query: 81 LSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEE 140
L DL E+D K+N +K L V L+S ++ +K R +R + + +L+
Sbjct: 1008 LDDLQAEED-----KVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKL 1062
Query: 141 VAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECL----MSKLVEAEMDGAA 196
+ + E++ L ER+K+ KDF Q + ++++ L K+ E +
Sbjct: 1063 AQESILDLENDKQQLD---ERLKK-KDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEE 1118
Query: 197 AAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHC- 255
+++ A + T + KTEKQ + R+ E L ++L T +L +++
Sbjct: 1119 LEEEIEAERAT--RAKTEKQRS-----DYARELEELSERLEEAGGVTSTQIELNKKREAE 1171
Query: 256 ----KEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTA 311
+ D E Q A++ L + ++ + L ++ ++ + Q+++ EK++ K
Sbjct: 1172 FLKLRRDLEEATLQHEAMVAALRKKHADS---VAELGEQIDNLQRVKQKLEKEKSEFKLE 1228
Query: 312 -SELSKSMESM---RGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKEL 367
+LS SMES+ + +L+ R+ E + S + + ++RS ++ + + + EL
Sbjct: 1229 IDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGEL 1288
Query: 368 KQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALST----LESWRSR 423
++ + + + + R+++ +++EE QL + K+ +A AL + + R +
Sbjct: 1289 SRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNA-LAHALQSSRHDCDLLREQ 1347
Query: 424 YNQVVKEKGDLELEIIVLNDRVTDLVNQQQT----LEEKMREDRDSLVERLHRQTAEYSA 479
Y + + K +L+ + N V + +T E++ E + L +RL + A
Sbjct: 1348 YEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEA 1407
Query: 480 FKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQ 539
+ A A +E + EV+ L V+ + + + K + D+V A
Sbjct: 1408 -------VNAKCASLEKTKQRLQGEVEDLMVDVERANSLA----AALDKKQRNFDKVLA- 1455
Query: 540 LERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERK 599
E K +E E+EA+ ++ +S +L +L + + E DQL+ +R+
Sbjct: 1456 ------EWKTKCEESQAELEASLKESRSLSTELFKLKNAYE-------EALDQLETVKRE 1502
Query: 600 NIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQ---- 655
N +L I+DL +I G + + + + E + L ++E E LE A+
Sbjct: 1503 NKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRI 1562
Query: 656 NIEFLQV-------IAKREEAIH-------------QSQLRLEEKTR-ECGTLARQLESA 694
+E QV IA+++E I QS L E ++R E L +++E
Sbjct: 1563 QLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGD 1622
Query: 695 IED-------ARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRR 747
+ + A RQ +T +H R+ Q ++ D + L L+ +RR
Sbjct: 1623 LNEIEIQLSHANRQAAETLKHL----RSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERR 1678
Query: 748 ---YQSRLQDLKDRLEQSESTNR 767
Q+ +++L+ LEQ+E +
Sbjct: 1679 ANLLQAEVEELRATLEQTERARK 1701
Score = 95.1 bits (235), Expect = 2e-19
Identities = 117/528 (22%), Positives = 216/528 (40%), Gaps = 67/528 (12%)
Query: 293 EVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQ 352
+++ LL+ + EK A E K+ + +L EA+ L ++ L + N
Sbjct: 836 KIKPLLKSAETEKEMATMKEEFQKTKD--------ELAKSEAKRKELEEKLVTLVQEKND 887
Query: 353 HKAEVEAIMEQLKELKQKGD---RDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLY 409
+ +V+A E L + +++ D + K L+ I+ ERAE EE ++ +L K
Sbjct: 888 LQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEE----INAELTAKKRK 943
Query: 410 VAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVER 469
+ + S L+ K+ DLEL + + N+ + L E++ L E
Sbjct: 944 LEDECSELK----------KDIDDLELTLAKVEKEKHATENKVKNLTEEL----SGLDET 989
Query: 470 LHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKS----- 524
+ + T E A + +++ EDK+N + +L+ V++ E ++ K
Sbjct: 990 IAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDL 1049
Query: 525 QVMKTRLEADEVAAQLERCDKEN-KILKDEMNKEIEAARRQFQSQLADLQ----QLPDIL 579
+ K +LE D AQ D EN K DE K+ + Q QS++ D Q Q +
Sbjct: 1050 ERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKI 1109
Query: 580 KITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLS 639
K +A++ E +++++ SD +E ++LE A + NK+
Sbjct: 1110 KELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKRE 1169
Query: 640 LKVDELERKLEATSAQNIEFLQVIAKRE-----------EAIHQSQLRLEEKTRECGTLA 688
+ +L R LE + Q+ + + K+ + + + + +LE++ E
Sbjct: 1170 AEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEI 1229
Query: 689 RQLESAIEDAR----------RQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLR 738
L S++E R +E A K Q + +L TQ SR +TE +L
Sbjct: 1230 DDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELS 1289
Query: 739 RSRDDAD-------RRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSS 779
R ++ + R Q+ Q ++ Q E N++ L+SS
Sbjct: 1290 RQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSS 1337
Score = 89.4 bits (220), Expect = 1e-17
Identities = 134/657 (20%), Positives = 272/657 (41%), Gaps = 74/657 (11%)
Query: 81 LSDLSTEDD----DSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKE 136
LS+L+T+ ++G +++R ++ +S+++ + K Q E KR LEE +
Sbjct: 1271 LSELTTQKSRLQTEAG--ELSRQLEEKESIVSQLSRSKQAFTQQTEE---LKRQLEEENK 1325
Query: 137 ELEEVAHELAETEHENTVLRHNIE-----------------------RMKEEKDFTILQK 173
+AH L + H+ +LR E R K E D I +
Sbjct: 1326 AKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETD-AIQRT 1384
Query: 174 KHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLL 233
+ L++ K+ L +L ++E A + +L+ T +L+ E + D+ L
Sbjct: 1385 EELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALD 1444
Query: 234 QKLSTFEETNRTLRDLLREQHCK-EDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDK 292
+K F++ + E + E S + L +L A E L ++ ++K
Sbjct: 1445 KKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENK 1504
Query: 293 EVEELLQEIQCEKAQ-AKTASELSKS---MESMRGHLQAQLRSKEAENSRLCMQIKNLER 348
+E+ + ++ + A+ KT EL KS +E + +Q L EA +I ++
Sbjct: 1505 NLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQL 1564
Query: 349 SGNQHKAEVEAIM----EQLKELKQKGDRDKESLKKAIRAQ-KERAE------KSEEYAE 397
Q K+E++ + E++++LK+ R E+++ A+ A+ + R E K E
Sbjct: 1565 ELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLN 1624
Query: 398 QLHVQLADKDLYVAEALSTLESWRSRY-------NQVVKEKGDLELEIIVLNDRVTDLVN 450
++ +QL+ + AE L L S + + + ++ + DL+ ++ ++ R L
Sbjct: 1625 EIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQA 1684
Query: 451 QQQTLE---EKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQ 507
+ + L E+ R + L +N L + +E L Q EV+
Sbjct: 1685 EVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVED 1744
Query: 508 LKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQS 567
+N E + K +A +A +L++ +++ + M K +E + Q
Sbjct: 1745 ASRDARNAE-------EKAKKAITDAAMMAEELKK-EQDTSAHLERMKKNLEQTVKDLQH 1796
Query: 568 QLADLQQLP------DILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKL 621
+L + +QL I K+ E ++ E + +L+G ++KN + + R++ +
Sbjct: 1797 RLDEAEQLALKGGKKQIQKL-ETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQS 1855
Query: 622 EMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLE 678
E R+ Q +L +KV +R+ E Q L K + + +++ R +
Sbjct: 1856 EEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERAD 1912
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 121 bits (303), Expect = 3e-27
Identities = 170/799 (21%), Positives = 329/799 (41%), Gaps = 100/799 (12%)
Query: 40 KRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRY 99
KR ++GD + SV ++ E +L + L ED+ +M
Sbjct: 1101 KRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQL----SLRVEDEQLLGAQMQ-- 1154
Query: 100 DKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNI 159
KKI L L+ E++ ++ R ++ E ELEE++ L E + R
Sbjct: 1155 -KKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGC 1213
Query: 160 ERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAA-AKQVMALKDTIGKLKTEKQMT 218
+ + E + + E ++ L + +GAA +QV +L+ KL+ EK
Sbjct: 1214 RKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSEL 1273
Query: 219 CTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADS 278
+++ L E L + ++ E+ RT D L E K + L ++LA+A +
Sbjct: 1274 RMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEE---------LQRQLADAST 1324
Query: 279 EKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELS-KSMESMRGHLQAQLRSKEAENS 337
++ RL Q + E+ LL+E +C +Q L+ +S+E +R L+ + ++K A
Sbjct: 1325 QRGRL----QTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAH 1380
Query: 338 RLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQK-ERAEKSEEYA 396
+ + + QH+ E EA E L+ L K + + + A +R E+ EE
Sbjct: 1381 AVQALRHDCDLLREQHEEEAEAQAE-LQRLLSKANAEVAQWRSKYEADAIQRTEELEEAK 1439
Query: 397 EQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEII----------------- 439
++L ++L + + V A + S ++ E D+ LE+
Sbjct: 1440 KKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLE 1499
Query: 440 -VLNDRVTDLVNQQQTLEEKMREDRDSLVERL-----HRQTAE-YSAFKLENERLKASFA 492
L +R Q+ LE RE R E H + E K EN+ L+ +
Sbjct: 1500 RALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEIS 1559
Query: 493 PMEDKLNQAHLEVQQLK--------------ASVKNYEGMIDNYKSQVMKTRLEADEVAA 538
+ D+++ + +Q+L+ A+++ EG ++ +++ ++ +LE +V A
Sbjct: 1560 DLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKA 1619
Query: 539 QLERC----DKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQ 594
+++R D+E L+ + +E+ + ++ + + K E L + + QL
Sbjct: 1620 EVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLG 1679
Query: 595 GYERKNIDLTAIISDLRSRIEHQ----GDKLEMAREKHQASQKENKQLSLKVDELERK-- 648
R+ + A ++++++ + ++ +A E H+ +Q ++ SL ELE
Sbjct: 1680 HATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRA 1739
Query: 649 ----------------LEATS------AQNIEFLQVIAKREEAIHQSQLRLEEKTRECGT 686
LEAT +QN L K E + Q +EE +E
Sbjct: 1740 ALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERRE 1799
Query: 687 LARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTEL-SQLRRSRDDAD 745
+ + AI DA E+ L KE+ + ++ L +T EL ++L + A
Sbjct: 1800 AEEKAKKAITDAAMMAEE-----LKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAAL 1854
Query: 746 RRYQSRLQDLKDRLEQSES 764
R + ++Q L+ ++ + E+
Sbjct: 1855 RGGKKQVQKLEAKVRELEA 1873
Score = 112 bits (279), Expect = 2e-24
Identities = 158/747 (21%), Positives = 320/747 (42%), Gaps = 159/747 (21%)
Query: 133 ERKEELEEVAHELAETEHENTVLRHNIERMKEEK---DFTIL----QKKHLQQEKECLMS 185
E K++++++ LA+ E E + ++ + EE D ++ +KK LQ+ + +
Sbjct: 998 ELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALG 1057
Query: 186 KLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRT 245
L +AE D +A T KL+ E+Q+ + +L ++K+L ++ T +
Sbjct: 1058 DL-QAEEDRVSAL--------TKAKLRLEQQVEDLEC-SLEQEKKL---RMDTERAKRKL 1104
Query: 246 LRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQD----------KDKEV- 294
DL Q D+ + +Q L ++L + DSE ++L L ++D K KE+
Sbjct: 1105 EGDLKLTQESVADAAQDKQQ---LEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQ 1161
Query: 295 ---EELLQEIQCEKA-----------QAKTASELSKSMESMRGHLQAQ---LRSKEAENS 337
EEL +E++ E+A A+ ELS+ +E G Q R +EAE
Sbjct: 1162 ARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELG 1221
Query: 338 RLCMQIKNLERSGNQHKAEVEAI--------------MEQLKELKQKGDRDKESLK---- 379
RL + LE + +H+A V A+ ++ L+ ++QK +++K L+
Sbjct: 1222 RL---RRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVD 1278
Query: 380 -----------------KAIRAQKERAEKSEEYAEQLHVQLAD----------------- 405
K R +++ +++ E+L QLAD
Sbjct: 1279 DLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSR 1338
Query: 406 ----KDLYVAE-------ALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQT 454
K+ +++ A +LE R + + K K L + L DL+ +Q
Sbjct: 1339 LLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALR-HDCDLLREQHE 1397
Query: 455 LEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKN 514
E + + + L+ + + + A++ + K E + ++ + +E+ + L +Q+ + V+
Sbjct: 1398 EEAEAQAELQRLLSKANAEVAQWRS-KYEADAIQRT-EELEEAKKKLALRLQEAEEGVEA 1455
Query: 515 YEGMIDNYKSQVMKTRLEADEVAAQLERC-------DKENKIL----------KDEMNKE 557
+ + ++ + E+++V +LER DK+ + L ++EM +E
Sbjct: 1456 ANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRE 1515
Query: 558 IEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQ 617
+EAA+R+ + +L +L E + L+ +R+N +L ISDL ++
Sbjct: 1516 LEAAQRESRGLGTELFRL-------RHGHEEALEALETLKRENKNLQEEISDLTDQVSLS 1568
Query: 618 GDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRL 677
G ++ + +A + E ++ ++E E LE + + +++ + + + +L
Sbjct: 1569 GKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDR---KL 1625
Query: 678 EEKTRECGTLARQLESAIEDARRQVE---QTKEHALSKERAAQNKILDLETQL------- 727
EK EC L R + A+E + ++ + + AL ++ + + DLE QL
Sbjct: 1626 AEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQA 1685
Query: 728 --SRTKTELSQLRRSRDDADRRYQSRL 752
++ T L Q + + A R + RL
Sbjct: 1686 TEAQAATRLMQAQLKEEQAGRDEEQRL 1712
Score = 100 bits (248), Expect = 7e-21
Identities = 162/753 (21%), Positives = 312/753 (41%), Gaps = 119/753 (15%)
Query: 49 NVRRSVRVKTKNPPHCLEITPPSSEKLVSV----MRLSDLSTEDDDSGHCKMNRYDKKID 104
NV R K C SE + V +L+D ST+ ++ ++
Sbjct: 1283 NVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRG-----RLQTESGELS 1337
Query: 105 SLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKE 164
L+ CL S++ K +A + LEE + +LEE + + H LRH+ + ++E
Sbjct: 1338 RLLEEKECLISQLSRGKA---LAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLRE 1394
Query: 165 EKDF-----------------------------TILQKKHLQQEKECLMSKLVEAEMDGA 195
+ + I + + L++ K+ L +L EAE
Sbjct: 1395 QHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVE 1454
Query: 196 AAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLS----TFEETNRTLRDLLR 251
AA + +L+ +L+TE + ++ T L +K EE R ++ R
Sbjct: 1455 AANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQR 1514
Query: 252 EQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKA-QAKT 310
E E ++R G L RL E L L+ ++K ++E + ++ + + K+
Sbjct: 1515 EL---EAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKS 1571
Query: 311 ASELSKSMESMRGHL-QAQLRSKEAENSRLCMQIKNL--ERSGNQHKAEVEAIM----EQ 363
EL K+ +++ G + Q +EAE + + K L + +Q KAEV+ + E+
Sbjct: 1572 IQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEE 1631
Query: 364 LKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVA----EALSTLES 419
L++ R ESL+ ++ A+ ++ +++ L D +L + +A +
Sbjct: 1632 CANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAA 1691
Query: 420 WRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVE-RLHRQTAEYS 478
R Q+ +E+ + E +L Q Q LE + L E R + E S
Sbjct: 1692 TRLMQAQLKEEQAGRDEE----QRLAAELHEQAQALERRASLLAAELEELRAALEQGERS 1747
Query: 479 AFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAA 538
E E L+A+ ++LN H + L K E + +V + E E
Sbjct: 1748 RRLAEQELLEAT-----ERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEE 1802
Query: 539 QLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKIT----EAKLAEC-QDQL 593
+ ++ + ++ +E+ KE Q A L+++ L+ T +A+L E Q L
Sbjct: 1803 KAKKAITDAAMMAEELKKE--------QDTSAHLERMKKTLEQTVRELQARLEEAEQAAL 1854
Query: 594 QGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATS 653
+G +++ L A + +L + ++ A QK++ + V + ER+++ +
Sbjct: 1855 RGGKKQVQKLEAKVRELEAELD--------------AEQKKHAEALKGVRKHERRVKELA 1900
Query: 654 AQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHA---L 710
Q E + +A+ ++ L +L+S ++ +RQ E+ ++ A L
Sbjct: 1901 YQAEEDRKNLARMQD------------------LVDKLQSKVKSYKRQFEEAEQQANTNL 1942
Query: 711 SKERAAQNKILDLETQLSRTKTELSQLR-RSRD 742
+K R AQ+++ D E + +T+ ++LR R+RD
Sbjct: 1943 AKYRKAQHELDDAEERADMAETQANKLRARTRD 1975
Score = 79.0 bits (193), Expect = 2e-14
Identities = 107/528 (20%), Positives = 238/528 (45%), Gaps = 49/528 (9%)
Query: 280 KARLLLLLQD-KDKEVEELLQEIQCEKAQAKTASELSK------SMESMRGHLQAQLRSK 332
KA LL +L++ +D+ + ++L +Q E + ++ +++ +++A K
Sbjct: 815 KAGLLGVLEELRDQRLAKVLTLLQARSRGRLMRLEYQRLLGGRDALFTIQWNIRAFNAVK 874
Query: 333 EAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKS 392
+L ++K L RS Q + E+ A+ +L+ L+ A+ A + + ++
Sbjct: 875 NWSWMKLFFKMKPLLRSA-QAEEELAALRAELR-----------GLRGALAAAEAKRQEL 922
Query: 393 EEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRV------- 445
EE + + D L + L R + ++K K LE ++ L++R+
Sbjct: 923 EETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVN 982
Query: 446 TDLVNQQQTLEEK---MREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAH 502
DL +++ LE++ +++D D L L + E A + + + L A +++ + +
Sbjct: 983 ADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLT 1042
Query: 503 LEVQQLKASVKNYEGMI---DNYKSQVMKTRLEADEVAAQLERCDKENKILK---DEMNK 556
E + L+ + + G + ++ S + K +L ++ LE ++ K L+ + +
Sbjct: 1043 KEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKR 1102
Query: 557 EIEAARRQFQSQLADL----QQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRS 612
++E + Q +AD QQL + LK +++L++ +++ + + I +L++
Sbjct: 1103 KLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQA 1162
Query: 613 RIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQ 672
R E ++LE R +K+ + + +++EL +LE + + KRE + +
Sbjct: 1163 RAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGR 1222
Query: 673 SQLRLEEKT-RECGTLA----RQLESAIE-----DARRQVEQTKEHALSKERAAQNKILD 722
+ LEE R T+A +Q E A E D+ ++V Q E S+ R + +
Sbjct: 1223 LRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAA 1282
Query: 723 LETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQ 770
L+R K +L R+ +D + ++++L+ +L + + +Q
Sbjct: 1283 NVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQ 1330
Score = 55.5 bits (132), Expect = 2e-07
Identities = 92/434 (21%), Positives = 192/434 (44%), Gaps = 59/434 (13%)
Query: 113 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTI-- 170
L+ K +GE+ + LEE + LE + + E + ++ ++R EKD
Sbjct: 1575 LEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECAN 1634
Query: 171 LQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKE 230
L++ H Q+ E L +A +D A+ L+ +K+M D+N L Q
Sbjct: 1635 LRRNH-QRAVESL-----QASLDAETRARNEA--------LRLKKKME-GDLNDLELQLG 1679
Query: 231 LLLQKLSTFEETNRTLRDLLREQHCKEDSER-----LMEQQGALLKR--LAEADSEKARL 283
++ + + R ++ L+E+ D E+ L EQ AL +R L A+ E+ R
Sbjct: 1680 HATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRA 1739
Query: 284 LLLLQDKDKEV--EELLQEI---------------QCEKAQAKTASELSKSMESMRGHLQ 326
L ++ + + +ELL+ Q +K +A A + E+ + +
Sbjct: 1740 ALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERRE 1799
Query: 327 AQLRSKEA--ENSRLCMQIKNLERSGNQHKAEVEAIMEQ-LKELKQKGDRDKESLKKAIR 383
A+ ++K+A + + + ++K E+ + H ++ +EQ ++EL+ R +E+ + A+R
Sbjct: 1800 AEEKAKKAITDAAMMAEELKK-EQDTSAHLERMKKTLEQTVRELQA---RLEEAEQAALR 1855
Query: 384 AQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLND 443
K++ +K E +L +L + AEAL + R ++ + + +
Sbjct: 1856 GGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLA---- 1911
Query: 444 RVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHL 503
R+ DLV++ Q+ + + + ++ + A+Y K ++E A E++ + A
Sbjct: 1912 RMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYR--KAQHELDDA-----EERADMAET 1964
Query: 504 EVQQLKASVKNYEG 517
+ +L+A ++ G
Sbjct: 1965 QANKLRARTRDALG 1978
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 120 bits (302), Expect = 4e-27
Identities = 156/685 (22%), Positives = 292/685 (42%), Gaps = 81/685 (11%)
Query: 89 DDSGHCK-----MNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAH 143
D HC + Y +K SL L+ ++K + + K E+ ++L++
Sbjct: 699 DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQ 758
Query: 144 ELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMA 203
+ E T L +E KE T L + + E + KL + E + +
Sbjct: 759 LNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFET 818
Query: 204 LKDTIG----KLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDS 259
L +L Q T T++ + +KE L+ +LST ++ + D L+ + +
Sbjct: 819 LSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEK 878
Query: 260 ERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSME 319
E + + A+L K +L + +++ KE +EL + ++ EK + SM+
Sbjct: 879 EN-QKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQ 937
Query: 320 SMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLK-------ELKQKGD 372
Q L+ E E +L I L++S Q K ++EA+ +LK EL+ K
Sbjct: 938 EQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQ 997
Query: 373 RDKESLKKAIRAQKERA-------EKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYN 425
+ + + A+KE+ EKS+E +QL ++ +E L+T + +S
Sbjct: 998 QQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRE---SELLATRQDLKS--- 1051
Query: 426 QVVKEKGDLELEIIVLNDR--------VTDLVNQQQTLEEKMREDRDSLVER---LHRQT 474
V+EK L E ++ N + +L + TLE+ + L ER L
Sbjct: 1052 --VEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQ 1109
Query: 475 AEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYE----GMIDNYK------- 523
E S + E K+ A +E+ + E+ +L +K+++ I N K
Sbjct: 1110 KEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLI 1169
Query: 524 SQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITE 583
Q ++ + +AD + A +E+ + +ILKD++ KE E +++F + A L
Sbjct: 1170 QQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKL----------H 1219
Query: 584 AKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVD 643
+++ E + ++ +E LT I+ L + L +++ Q+SQ+ +L + D
Sbjct: 1220 SEIKEKEVGMKKHEENEAKLTMQITAL-------NENLGTVKKEWQSSQRRVSELEKQTD 1272
Query: 644 ELERK---LEATSAQNIE----FLQVIAKREEAIHQSQLRLEEKTREC-GTLARQLESAI 695
+L + LEAT N + L+ K E I + Q ++ E R+ T A E
Sbjct: 1273 DLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGR 1332
Query: 696 EDARRQVEQTKEHALSKERAAQNKI 720
E+ Q++ T+ AL+++ A N++
Sbjct: 1333 ENQSLQIKHTQ--ALNRKWAEDNEV 1355
Score = 119 bits (299), Expect = 9e-27
Identities = 161/785 (20%), Positives = 325/785 (41%), Gaps = 89/785 (11%)
Query: 67 ITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQM 126
+T S+E +L + TE+ + K + +++K L + +KS+ ++ R+
Sbjct: 130 VTDSSAELQSLEQQLEEAQTENFNIKQMK-DLFEQKAAQLATEIADIKSKYDEERSLREA 188
Query: 127 AKRFLEERKEELEEVAHEL-------------------------AETEHENTVLRHNIER 161
A++ + EEL + A + +T +N L E
Sbjct: 189 AEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERES 248
Query: 162 MKEEKDFTILQKKHLQQEKEC--LMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTC 219
K + + LQ ++ E L S+L + + A +++ LK ++ +L T+K T
Sbjct: 249 EKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNEL-TQKNQTL 307
Query: 220 TDINTLTRQKEL--LLQKLSTFEETNRTLRDLLREQ--HCKEDSERLMEQQGALLKRLAE 275
T+ N L ++++ L +K + + + ++ L ++ C++ RL + + L R+
Sbjct: 308 TE-NLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETS-LHRIHV 365
Query: 276 ADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASE----------------LSKSME 319
SEK L+++ EVE Q ++ E Q + E SK +E
Sbjct: 366 ELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLE 425
Query: 320 SMR------GHLQAQ-------LRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKE 366
+ R G L+ Q L KE + + L +++ LE + + QL +
Sbjct: 426 TERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDK 485
Query: 367 LKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQ 426
KQ+ +++++L+++ A+ A+ EQ+ Q+ DKD + + L+ + +
Sbjct: 486 TKQQ-HQEQQALQQSTTAKLREAQND---LEQVLRQIGDKDQKIQNLEALLQKSKENISL 541
Query: 427 VVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENER 486
+ KE+ DL + I + T ++NQ Q ++E L E+L Q+ + K E
Sbjct: 542 LEKEREDLYAK-IQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESH---KQAQEN 597
Query: 487 LKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKE 546
L + L A V L+ SV ++ K +V + ++ L +
Sbjct: 598 LHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAA 657
Query: 547 NKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQD-------QLQGYERK 599
+ ++ ++ A+ Q + +L ++ L AKL + Q+ L+ Y+ K
Sbjct: 658 KTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEK 717
Query: 600 NIDLTAIISDLRSRIEH-QGDKLEMAREKHQASQ------KENKQLSLKVDELERKLEAT 652
+ L +L +I+ + D LE+ K QA Q + N L L+ EL ++LE
Sbjct: 718 YLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEME 777
Query: 653 SAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSK 712
+ K+ EA+ + +L ++ E L + E+ ++ + Q E+ +
Sbjct: 778 KEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTT 837
Query: 713 ERAAQNKILDLE---TQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSM 769
Q ++ E T+LS K +LS++ S ++ ++ Q K + E T + +
Sbjct: 838 VTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKEL 897
Query: 770 QNYVQ 774
++ +Q
Sbjct: 898 KHQLQ 902
Score = 106 bits (265), Expect = 7e-23
Identities = 139/688 (20%), Positives = 306/688 (44%), Gaps = 74/688 (10%)
Query: 113 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 172
LK+E K + +R+ ++ + + E+ ++ +L ETE + L R+KE++ + +
Sbjct: 391 LKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQ---LGEAHGRLKEQRQLSSEK 447
Query: 173 KKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTE-------KQMTCTDINTL 225
+Q+ L KL E L+ + K K + +Q T +
Sbjct: 448 LMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREA 507
Query: 226 TRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLL 285
E +L+++ ++ + L LL Q KE+ L +++ L ++ + E A +L
Sbjct: 508 QNDLEQVLRQIGDKDQKIQNLEALL--QKSKENISLLEKEREDLYAKIQAGEGETA-VLN 564
Query: 286 LLQDKD----KEVEELLQEIQCEKAQAKTASE-LSKSMESMRGHLQA---QLRSKEAENS 337
LQ+K+ ++V +L ++++ + K A E L ++ + HL+A ++ S E +
Sbjct: 565 QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVN 624
Query: 338 RLCMQIKNLERSGNQHKAEVEAIMEQL-----KELKQKGDRDK--ESLKKAIRAQKERAE 390
L Q+ + +Q +++A E L + Q+ D ++ + A++ +++
Sbjct: 625 ELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELN 684
Query: 391 KSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVN 450
K +Q+ +L DK + ++ S L+ ++ +Y + ++ +LE +I L
Sbjct: 685 KITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL--------- 735
Query: 451 QQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKA 510
+ +LE ++ ++ ++ L +Q + +L L ++ ++ L++Q+
Sbjct: 736 EADSLE--VKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSE 793
Query: 511 SVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLA 570
+ +++ K ++ K E + E +E KI +E+N I+ + Q
Sbjct: 794 A-------LESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKM 846
Query: 571 DLQQLPDILKITEAKLAECQDQLQG----YERKNIDLTAIISDLRSRIEHQGDKLEMARE 626
+ + L L + KL++ D L+ +E++N A I DL + +L++ E
Sbjct: 847 EKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQME 906
Query: 627 KHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGT 686
QKE K+ LE++ EA+ +E + +E + Q+Q L++ +E
Sbjct: 907 NTLKEQKELKK------SLEKEKEASHQLKLE----LNSMQEQLIQAQNTLKQNEKE--- 953
Query: 687 LARQLESAIEDARRQVEQTKE--HALSKE-RAAQNKILDLETQLSRTKTELSQLRRSRDD 743
+QL+ I + ++ EQ K+ AL E + A + +LE +L + T+ +Q +
Sbjct: 954 -EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAE-- 1010
Query: 744 ADRRYQSRLQDLKDRLEQSESTNRSMQN 771
+ ++ L++ E+S+ T + +Q+
Sbjct: 1011 -----KEKISVLQNNYEKSQETFKQLQS 1033
Score = 97.4 bits (241), Expect = 5e-20
Identities = 146/739 (19%), Positives = 303/739 (41%), Gaps = 99/739 (13%)
Query: 71 SSEKLVSV-MRLSDLSTEDDDSGHCKMNRYDKKIDS-------LMNAVGCLKSEVKMQKG 122
SSEKL+ +++DL K++R ++++ L + + K + + Q+
Sbjct: 444 SSEKLMDKEQQVADLQL--------KLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQA 495
Query: 123 ERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKEC 182
+Q L E + +LE+V ++ + + + L +++ KE L++E+E
Sbjct: 496 LQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISL-------LEKERED 548
Query: 183 LMSKLVEAEMDGAAA----------AKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELL 232
L +K+ E + A +QV L + + + +++ ++++
Sbjct: 549 LYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAH 608
Query: 233 LQ----KLSTFEETNRTLRDLLREQ---------HCKEDSERLMEQQGALLKRLAEADSE 279
L+ ++ + E + L L E K +E L+ + A + A+ +
Sbjct: 609 LRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNH 668
Query: 280 KARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRL 339
LQDK +E+ ++ ++ A+ + E +ES + + S E + L
Sbjct: 669 LDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEEL 728
Query: 340 CMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQL 399
QIK LE + KA E ++ L++ +Q L+ ++ E +E
Sbjct: 729 EGQIKKLEADSLEVKASKEQALQDLQQQRQL----NTDLELRATELSKQLEMEKEIVSST 784
Query: 400 HVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKM 459
+ L K LES + + + +EK L+ + +TL ++
Sbjct: 785 RLDLQKKS-------EALESIKQKLTKQEEEKQILKQDF--------------ETLSQET 823
Query: 460 REDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMI 519
+ + L R+ E K+E E L + ++DKL++ LK S +E
Sbjct: 824 KIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVS---DSLKNSKSEFEKEN 880
Query: 520 DNYKSQVM---KTRLE-ADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQL 575
K+ ++ KT E ++ Q+E KE K LK + KE EA+ Q + +L +Q+
Sbjct: 881 QKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEAS-HQLKLELNSMQE- 938
Query: 576 PDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKEN 635
+L + Q+ L+ E++ L I++L+ E + ++E A Q E
Sbjct: 939 ---------QLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIE-------ALQGEL 982
Query: 636 KQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAI 695
K L+ ELE KL+ Q + L ++ + + + +E ++ + ES +
Sbjct: 983 KIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESEL 1042
Query: 696 EDARRQVEQTKEH-ALSKER--AAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRL 752
R+ ++ +E +L++E + +N+I + + KT + L + +++ Q R
Sbjct: 1043 LATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERC 1102
Query: 753 QDLKDRLEQSESTNRSMQN 771
+ L+D ++ + + N
Sbjct: 1103 KALQDIQKEKSLKEKELVN 1121
Score = 96.7 bits (239), Expect = 8e-20
Identities = 145/654 (22%), Positives = 289/654 (44%), Gaps = 87/654 (13%)
Query: 145 LAETEHENTVLRHNIE----RMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAA--AA 198
LA + T+LR ++ +KEEK ++ KK L++ + EA+ DG ++
Sbjct: 78 LALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQ---EAKPDGLVTDSS 134
Query: 199 KQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKED 258
++ +L+ + + +TE + + K+L FE+ L + + K D
Sbjct: 135 AELQSLEQQLEEAQTENF-------NIKQMKDL-------FEQKAAQLATEIADIKSKYD 180
Query: 259 SER-LMEQQGALLKRLAEADSEKARLL------LLLQDKDKEVEELLQE-IQCEKAQAKT 310
ER L E + RL E +++A ++ LL + ++V L +E +Q +
Sbjct: 181 EERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNM 240
Query: 311 ASELSKSMESMRGH---LQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKEL 367
E + E ++ LQ+Q S EA S+L ++ + + E++ + + EL
Sbjct: 241 TLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNEL 300
Query: 368 KQKGDRDKESLKKAIRAQKERAEK-SEEYAEQLHVQ--LADKDL---YVAEALSTLESWR 421
QK E+L K + + EK +EE + ++Q L KDL + LS E+
Sbjct: 301 TQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSL 360
Query: 422 SRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFK 481
R + + EKG+ + L + ++++ + Q L+ + ++ + R+ E +
Sbjct: 361 HRIHVELSEKGEATQK---LKEELSEVETKYQHLKAEFKQLQQQ------REEKEQHGLQ 411
Query: 482 LENE--RLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQ 539
L++E +L + E +L +AH +++ + + E ++D + QV +L+ + Q
Sbjct: 412 LQSEINQLHSKLLETERQLGEAHGRLKEQRQL--SSEKLMDK-EQQVADLQLKLSRLEEQ 468
Query: 540 LERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERK 599
L KE E+ +++ ++Q Q Q A LQQ T AKL E Q+ L+ R+
Sbjct: 469 L----KEKVTNSTELQHQLDKTKQQHQEQQA-LQQS------TTAKLREAQNDLEQVLRQ 517
Query: 600 NIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEF 659
I D +I++ L+ ++E +KE + L K+ E +
Sbjct: 518 -------IGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETA--------- 561
Query: 660 LQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSKERAAQNK 719
V+ + +E H Q ++ + T + + + A E+ QV++ K H RAAQ++
Sbjct: 562 --VLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHL----RAAQDR 615
Query: 720 ILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYV 773
+L LET ++ ++L++ + D + +++ + L + +QN++
Sbjct: 616 VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHL 669
Score = 79.3 bits (194), Expect = 1e-14
Identities = 105/517 (20%), Positives = 213/517 (41%), Gaps = 81/517 (15%)
Query: 290 KDKEVEELLQEIQCEKAQAKT----ASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKN 345
K +V L QE+Q +A K + EL K +E +G L+ +EA+ L
Sbjct: 81 KRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQG-----LQQQEAKPDGLV----- 130
Query: 346 LERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLAD 405
AE++++ +QL+E + + K+ + E+ A QL ++AD
Sbjct: 131 -----TDSSAELQSLEQQLEEAQTENFNIKQM-----------KDLFEQKAAQLATEIAD 174
Query: 406 KDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVN--------------- 450
E S E+ + ++ +E L E V+ D T+L+
Sbjct: 175 IKSKYDEERSLREAAEQKVTRLTEE---LNKEATVIQDLKTELLQRPGIEDVAVLKKELV 231
Query: 451 QQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKA 510
Q QTL + M +R+ E+L K E ++L++ +A E ++Q E+ +
Sbjct: 232 QVQTLMDNMTLERERESEKL----------KDECKKLQSQYASSEATISQLRSELAKGPQ 281
Query: 511 SVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQL- 569
V Y + KS V + + + L + +++ L+++ N+E +++ Q+ L
Sbjct: 282 EVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEE-SVSKKNIQATLH 340
Query: 570 ---ADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMARE 626
D QQL L +E L +L L +S++ ++ +H + + ++
Sbjct: 341 QKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQ 400
Query: 627 KHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGT 686
+ + ++ QL ++++L KL T Q + ++ RL+E+ +
Sbjct: 401 QREEKEQHGLQLQSEINQLHSKLLETERQ--------------LGEAHGRLKEQRQLSSE 446
Query: 687 LARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADR 746
E + D + ++ + +E KE+ + +L+ QL +TK + + + +
Sbjct: 447 KLMDKEQQVADLQLKLSRLEEQL--KEKVTNST--ELQHQLDKTKQQHQEQQALQQSTTA 502
Query: 747 RYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSSYANV 783
+ + DL+ L Q ++ +QN L+ S N+
Sbjct: 503 KLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENI 539
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 120 bits (302), Expect = 4e-27
Identities = 181/841 (21%), Positives = 362/841 (43%), Gaps = 121/841 (14%)
Query: 40 KRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSV-MRLSDLSTEDDDSGHCKMNR 98
KR ++GD + S + T+N L +EKL +S+L + +D + +
Sbjct: 1056 KRKLEGDLKLAQEST-MDTENDKQQL------NEKLKKKEFEMSNLQGKIEDEQALAI-Q 1107
Query: 99 YDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTV-LRH 157
KKI L + L+ E++ ++ R A++ + ELEE++ L E + +
Sbjct: 1108 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1167
Query: 158 NIERMKE-EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQ 216
N +R E +K L++ LQ E + A+ A +Q+ +L+ KL+ EK
Sbjct: 1168 NKKREAEFQKMRRDLEESTLQHEATAAALRKKHAD-SVAELGEQIDSLQRVKQKLEKEKS 1226
Query: 217 MTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSE------------RLME 264
+IN L E + + + FE+ RTL D L E KE+ + RL
Sbjct: 1227 ELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHT 1286
Query: 265 QQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGH 324
+ G ++L E D+ ++L Q +++EEL ++++ + K S L+ +++S R
Sbjct: 1287 ESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLE---EETKAKSTLAHALQSARHD 1343
Query: 325 ---LQAQLRSKEAENSRL--CMQIKNLERSGNQHKAEVEAIM--EQLKELKQKGDRDKES 377
L+ Q ++ + L M N E + + K E +AI E+L+E K+K + +
Sbjct: 1344 CDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQD 1403
Query: 378 LKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALS--------------TLESWRSR 423
++ + A + E+ ++L ++ D + V + + L W+ +
Sbjct: 1404 AEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQK 1463
Query: 424 YNQV-------VKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAE 476
Y + KE L E+ + + + ++ +TL+ + + + + + L Q AE
Sbjct: 1464 YEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISD-LTEQIAE 1522
Query: 477 YSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMI-------DNYKSQVMKT 529
E E++K ++ + ++ +++ +AS+++ EG I + KS++ +
Sbjct: 1523 GGKHIHELEKVKKQ---LDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRK 1579
Query: 530 RLEADEVAAQLER------------CDKENKILKD-------------EMNKEIEAARRQ 564
E DE QL+R D E + D EM ++ A RQ
Sbjct: 1580 IAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQ 1639
Query: 565 FQSQLADLQQLPDILKITEAKLAEC-------QDQLQGYERKNIDLTAIISDLRSRIE-- 615
L +L+ ILK T+ L + ++QL ER+ + A + +LR+ +E
Sbjct: 1640 AAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERT 1699
Query: 616 HQGDKLEM-----AREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREE-- 668
+G K+ A E+ Q +N L +LE + + + +Q EE
Sbjct: 1700 ERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKA 1759
Query: 669 --AIHQSQLRLEEKTRECGTLA------RQLESAIEDARRQVEQTKEHALSKERAAQNKI 720
AI + + EE +E T A + +E ++D + ++++ ++ AL + + +I
Sbjct: 1760 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLAL---KGGKKQI 1816
Query: 721 LDLETQLSRTKTELSQLRRSRDDAD---RRYQSRLQDLKDRLEQSESTNRSMQNYVQFLK 777
LE ++ ++E+ ++ +A R+++ R+++L + E+ +Q+ V L+
Sbjct: 1817 QKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQ 1876
Query: 778 S 778
+
Sbjct: 1877 T 1877
Score = 111 bits (277), Expect = 3e-24
Identities = 144/695 (20%), Positives = 311/695 (44%), Gaps = 69/695 (9%)
Query: 113 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 172
+K +K + E++MA KEE E+ ELA+TE + L EEK T++Q
Sbjct: 840 IKPLLKSAETEKEMANM-----KEEFEKTKEELAKTEAKRKEL--------EEKMVTLMQ 886
Query: 173 KKH-LQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINT-LTRQKE 230
+K+ LQ + + L +AE K + L+ I K TE+ +IN LT +K
Sbjct: 887 EKNDLQLQVQAEADALADAEERCDQLIKTKIQLEAKI-KEVTERAEDEEEINAELTAKKR 945
Query: 231 LLLQKLS----TFEETNRTLRDLLREQHCKEDS-ERLMEQQGALLKRLAEADSEKARLLL 285
L + S ++ TL + +E+H E+ + L E+ L + +A+ EK L
Sbjct: 946 KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKAL-- 1003
Query: 286 LLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKN 345
+ ++ L ++Q E+ + T ++ +E L+ L + +LCM +
Sbjct: 1004 -----QEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLE----QEKKLCM---D 1051
Query: 346 LERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKK---AIRAQKERAEKSEEYAEQLHVQ 402
LER+ + + +++ E + + + E LKK + + + E + A QL +
Sbjct: 1052 LERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKK 1111
Query: 403 LADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMRED 462
+ + + E +E+ R+ + K++ DL E+ +++R+ + + + +M +
Sbjct: 1112 IKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE-AGGATSAQIEMNKK 1170
Query: 463 RDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNY 522
R++ +++ R E + L++E A+ A + K + E+ + S++ + ++
Sbjct: 1171 REAEFQKMRRDLEEST---LQHE---ATAAALRKKHADSVAELGEQIDSLQRVKQKLEKE 1224
Query: 523 KSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKIT 582
KS++ ++E +++A+ +E K K ++M + +E + +++ + Q+L + L
Sbjct: 1225 KSEL---KMEINDLASNMETVSKA-KANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQ 1280
Query: 583 EAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKV 642
+A+L + + R+ + A++S L + ++E + + + K L+ +
Sbjct: 1281 KARL---HTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHAL 1337
Query: 643 -------DELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLE----EKTRECGTLARQL 691
D L + E E + ++K + Q + + E ++T E ++L
Sbjct: 1338 QSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKL 1397
Query: 692 ESAIEDARRQVEQTKEHALSKERA---AQNKILDLETQLSRTKT---ELSQLRRSRDDAD 745
++DA VE S E+ QN++ DL + R+ L + +R+ D
Sbjct: 1398 AQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVL 1457
Query: 746 RRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSSY 780
++ + ++ + LE S+ +RS+ + +K++Y
Sbjct: 1458 AEWKQKYEETQAELEASQKESRSLSTELFKVKNAY 1492
Score = 107 bits (266), Expect = 6e-23
Identities = 147/734 (20%), Positives = 316/734 (43%), Gaps = 114/734 (15%)
Query: 115 SEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKK 174
+E+ Q Q K+ LE+ K EL+ ++LA + + N E+M + + + K
Sbjct: 1205 AELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIK 1264
Query: 175 HLQQEKECLMSKL----VEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKE 230
++E++ L+++L + ++Q+ + +L KQ I L RQ E
Sbjct: 1265 TKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLE 1324
Query: 231 LLLQKLSTFEETNRTLR---DLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLL 287
+ ST ++ R DLLREQ+ +E+ E E Q + K +E + +
Sbjct: 1325 EETKAKSTLAHALQSARHDCDLLREQY-EEEQEAKAELQRGMSKANSEVAQWRTKYETDA 1383
Query: 288 QDKDKEVEE----LLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSR---LC 340
+ +E+EE L Q +Q + + + S+E + LQ ++ + R C
Sbjct: 1384 IQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAAC 1443
Query: 341 MQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAE--- 397
+ + +R+ ++ AE + E+ + + ++ SL + K E+S ++ E
Sbjct: 1444 IALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLK 1503
Query: 398 ----QLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDL-----ELEIIVLND----- 443
L +++D +AE + Q+ EK +L E E + ++
Sbjct: 1504 RENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKIL 1563
Query: 444 RVTDLVNQQQT-LEEKMREDRDSL--VERLHRQTAEYSAFKLENE------------RLK 488
R+ +NQ ++ ++ K+ E + L ++R H + E L+ E +++
Sbjct: 1564 RIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKME 1623
Query: 489 ASFAPMEDKLNQAHLEVQQLKASVKNYEGMI--------------DNYKSQVMKT----- 529
ME +LN A+ + + +++N +G++ D+ K Q+
Sbjct: 1624 GDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRAN 1683
Query: 530 --RLEADEVAAQLERCDKENKILKDEM--------------------NKEIEAARRQFQS 567
+ E +E+ A LER ++ K+ + E+ K++E Q Q
Sbjct: 1684 LMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQG 1743
Query: 568 QLADLQQ------------LPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIE 615
++ D+ Q + D + E +L + QD ER ++ + DL+ R++
Sbjct: 1744 EMEDIVQEARNAEEKAKKAITDAAMMAE-ELKKEQDTSAHLERMKKNMEQTVKDLQLRLD 1802
Query: 616 HQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQL 675
+ ++L + + +K+ ++L +V ELE ++E+ N+E ++ + K E + +
Sbjct: 1803 -EAEQLAL-----KGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTY 1856
Query: 676 RLEEKTR---ECGTLARQLESAIEDARRQVEQTKEHA---LSKERAAQNKILDLETQLSR 729
+ EE + L +L++ ++ +RQ E+ +E + L+K R Q+++ + + +
Sbjct: 1857 QTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADI 1916
Query: 730 TKTELSQLR-RSRD 742
++++++LR +SR+
Sbjct: 1917 AESQVNKLRVKSRE 1930
Score = 105 bits (263), Expect = 1e-22
Identities = 115/502 (22%), Positives = 209/502 (41%), Gaps = 67/502 (13%)
Query: 293 EVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQ 352
+++ LL+ + EK A E K+ E +L EA+ L ++ L + N
Sbjct: 839 KIKPLLKSAETEKEMANMKEEFEKTKE--------ELAKTEAKRKELEEKMVTLMQEKND 890
Query: 353 HKAEVEAIMEQLKELKQKGD---RDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLY 409
+ +V+A + L + +++ D + K L+ I+ ERAE EE ++ +L K
Sbjct: 891 LQLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEE----INAELTAKKRK 946
Query: 410 VAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVER 469
+ + S L+ K+ DLEL + + N+ + L E+M L E
Sbjct: 947 LEDECSELK----------KDIDDLELTLAKVEKEKHATENKVKNLTEEMA----GLDET 992
Query: 470 LHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVM-- 527
+ + T E A + +++ EDK+N +L+ V + EG ++ K M
Sbjct: 993 IAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDL 1052
Query: 528 ---KTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEA 584
K +LE D AQ D EN D QQL + LK E
Sbjct: 1053 ERAKRKLEGDLKLAQESTMDTEN-----------------------DKQQLNEKLKKKEF 1089
Query: 585 KLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDE 644
+++ Q +++ + I L I +L++RIE +++E R ++K+ LS +++E
Sbjct: 1090 EMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1149
Query: 645 LERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQ 704
+ +LE +++ KRE + + LEE T + A L D+ V +
Sbjct: 1150 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADS---VAE 1206
Query: 705 TKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRD---DADRRYQSRLQDLKDRLEQ 761
E S +R Q LE + S K E++ L + + A ++ + L+D+L +
Sbjct: 1207 LGEQIDSLQRVKQK----LEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSE 1262
Query: 762 SESTNRSMQNYVQFLKSSYANV 783
++ Q + L + A +
Sbjct: 1263 IKTKEEEQQRLINELSAQKARL 1284
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 119 bits (298), Expect = 1e-26
Identities = 155/722 (21%), Positives = 325/722 (45%), Gaps = 71/722 (9%)
Query: 90 DSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQM---AKRFLEERKEELEEVAHELA 146
D +++RY +++ + K+ V+ K + Q+ K LE++ E + +L
Sbjct: 323 DKLESEVSRYKERLHD----IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378
Query: 147 ETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKD 206
E E EN L+ + M+ E+D + +K +++ LM + + EM + + + L
Sbjct: 379 ELEKENLQLKAKLHDMEMERD---MDRKKIEE----LMEENMTLEMAQKQSMDESLHLGW 431
Query: 207 TIGKLKTEKQMTCTDINTLTRQ-KELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQ 265
+ ++ +++ +L + EL +L E N++L + E DS +E
Sbjct: 432 ELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDS---VEG 488
Query: 266 QGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQ-CEKAQAKTASELSKSMESMRGH 324
+ + ++ + + ++ + +L+++ + ++ LQ Q K K ++L K++E++R +
Sbjct: 489 NASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLREN 548
Query: 325 LQAQLRSKEAENSRLCMQIKNL-ERSGNQHKAEVEAI-------MEQLKELKQKGDR--- 373
+ Q++ E EN L + +L +RS +A V+ I E +KE K +
Sbjct: 549 SERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEF 608
Query: 374 DKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGD 433
+K +KK + KE+ E++EE +LH L ++ + + ++ L+ + + +E +
Sbjct: 609 EKRQIKKELEHYKEKGERAEELENELH-HLEKENELLQKKITNLKITCEKIEALEQENSE 667
Query: 434 LELEIIVLN---DRVTDLVNQQQTLE-EKMREDRDSLVERLHRQTAEYSAFKLENERLKA 489
LE E L D +L Q ++LE E + D ++L L R ++ +L+
Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENL--ELRRNVESLKCASMKMAQLQL 725
Query: 490 SFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKI 549
+E + Q ++ LKAS K E + +Y+ +E + LE +K+ +
Sbjct: 726 ENKELESEKEQLKKGLELLKASFKKTERLEVSYQG----LDIENQRLQKTLENSNKKIQQ 781
Query: 550 LKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISD 609
L+ E+ +++E + Q L +L+ L+ E + + + E+ L
Sbjct: 782 LESEL-QDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
Query: 610 LRSRIEHQGDKLEMAREKHQASQKENKQLS----------LKVDELERK-LEATSAQNIE 658
LR + E + LE K +KENK LS +++ ELE++ E I+
Sbjct: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID 900
Query: 659 FLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSKERAAQN 718
++ RE+ + + +L+ ++ + L +LE ++ KE L E++
Sbjct: 901 IKTLVTLREDLVSE-KLKTQQMNNDLEKLTHELE--------KIGLNKERLLHDEQSTD- 950
Query: 719 KILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKS 778
D +L +K E S L++S + + ++ L+ RLE+S + N+ ++ ++ +K
Sbjct: 951 ---DSRYKLLESKLE-STLKKSLEIK----EEKIAALEARLEESTNYNQQLRQELKTVKK 1002
Query: 779 SY 780
+Y
Sbjct: 1003 NY 1004
Score = 113 bits (283), Expect = 6e-25
Identities = 159/742 (21%), Positives = 318/742 (42%), Gaps = 118/742 (15%)
Query: 113 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 172
LK+++ + ER M ++ +EE EE + ++ E+ L +E++ + +
Sbjct: 387 LKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAP 446
Query: 173 KKHLQQE-KECLMSKLVEAEMDGAAAAKQVMALKDTIG----------KLKTEKQMTCTD 221
+K L E E S+L++ EM+ + K V L+ T+ K++ E Q
Sbjct: 447 QKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKK 506
Query: 222 INTLTRQKELLLQKLSTFEETNRTLRDLLRE--------QHCKEDSER---LMEQQGALL 270
+ L + ++Q+ + + +DL++E + +E+SER ++EQ+ L
Sbjct: 507 VEILENE---IVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL 563
Query: 271 KRLAEADSEKARLLLLLQDKD------------KEVEELLQEIQCEKAQAKTASELSKSM 318
+ + +++++ + KD KE L +I+ EK Q K E K
Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK 623
Query: 319 ESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESL 378
L+ +L E EN L +I NL+ + ++EA+ ++ EL +R+ L
Sbjct: 624 GERAEELENELHHLEKENELLQKKITNLKITCE----KIEALEQENSEL----ERENRKL 675
Query: 379 KKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEI 438
KK + + K + E E+ + QL +++L + + +L+ + Q+ E +LE E
Sbjct: 676 KKTLDSFKNLTFQLES-LEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESE- 733
Query: 439 IVLNDRVTDLVNQQQTLEEKMREDRDSL---VERLHRQTAEYSAFKLENERLKASFAPME 495
+E++++ + L ++ R Y +EN+RL+ +
Sbjct: 734 -----------------KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN 776
Query: 496 DKLNQAHLEVQQLKASVKNYEGMIDNYK------SQVMKTRLEADEVAAQLER----CDK 545
K+ Q E+Q L+ + + ++ K Q+ K ++ +QLE+ +K
Sbjct: 777 KKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEK 836
Query: 546 ENKIL------KDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQ-DQLQGYER 598
ENK L KD +E + + L + I K + +L E + + + +R
Sbjct: 837 ENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKR 896
Query: 599 KNIDLTAIIS---DLRS-------------RIEHQGDKLEMAREK--HQASQKENKQLSL 640
ID+ +++ DL S ++ H+ +K+ + +E+ H ++ + L
Sbjct: 897 ATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKL 956
Query: 641 KVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIE--DA 698
LE KLE+T +++E +EE I + RLEE T L ++L++ + +A
Sbjct: 957 ----LESKLESTLKKSLEI------KEEKIAALEARLEESTNYNQQLRQELKTVKKNYEA 1006
Query: 699 RRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRR---YQSRLQDL 755
+Q Q +E + + E + T EL +++ + +R Q+ Q L
Sbjct: 1007 LKQ-RQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQAL 1065
Query: 756 KDRLEQSESTNRSMQNYVQFLK 777
K +L+Q E+ N ++Q + L+
Sbjct: 1066 KTQLKQLETQNNNLQAQILALQ 1087
Score = 104 bits (260), Expect = 3e-22
Identities = 146/688 (21%), Positives = 289/688 (42%), Gaps = 78/688 (11%)
Query: 113 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 172
L E+ K + + ++ LEE+ E+L + EL + E ++
Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQME---------------------IE 287
Query: 173 KKHLQQEKECLMSKLVEAEM--DGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKE 230
K LQQE L+S A M D A ++ D + + + DI + E
Sbjct: 288 LKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVE 347
Query: 231 LLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLK-RLAEADSEKARLLLLLQD 289
L + ET L D L + D +E++ LK +L + + E+ D
Sbjct: 348 ELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMER--------D 399
Query: 290 KD-KEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLER 348
D K++EEL++E + K + + S + + EA L ++ L
Sbjct: 400 MDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNEL-T 458
Query: 349 SGNQHKAEVE--AIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADK 406
S K E+E ++ + ++EL+ D + + K ++ +KE S++ V++ +
Sbjct: 459 SSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKK------VEILEN 512
Query: 407 DLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSL 466
+ + + +L++ ++ ++KEK LE I L + + + E + + SL
Sbjct: 513 E--IVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSL 570
Query: 467 VERLH-RQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQ 525
+R A + EN+ L S KL++ E +Q+K +++Y+
Sbjct: 571 RQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK--------- 621
Query: 526 VMKTRLEADEVAAQLERCDKENKILKDEM-NKEIEAAR-RQFQSQLADLQQLPDILKITE 583
+ A+E+ +L +KEN++L+ ++ N +I + + + ++L++ LK T
Sbjct: 622 --EKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTL 679
Query: 584 AKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVD 643
QL+ E++N L +LR +E L+ A K Q ENK+L + +
Sbjct: 680 DSFKNLTFQLESLEKENSQLDEENLELRRNVE----SLKCASMKMAQLQLENKELESEKE 735
Query: 644 ELERKLEATSA--QNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQ 701
+L++ LE A + E L+V + + +Q RL++ +QLES ++D +
Sbjct: 736 QLKKGLELLKASFKKTERLEVSYQGLDIENQ---RLQKTLENSNKKIQQLESELQDLEME 792
Query: 702 VEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADR-----RYQSRLQDL- 755
QT + L + + + ++ LE + + E SQL + + ++ R Q+ ++D
Sbjct: 793 -NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Query: 756 ----KDRLEQSESTNRSMQNYVQFLKSS 779
++ E N+++ + K S
Sbjct: 852 LEENNVKIGNLEKENKTLSKEIGIYKES 879
Score = 99.8 bits (247), Expect = 9e-21
Identities = 176/844 (20%), Positives = 342/844 (40%), Gaps = 130/844 (15%)
Query: 29 KPSATSSQKSHKRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTED 88
K S + Q K MK + + +++ +N ++I +E L + S L
Sbjct: 518 KQSLQNCQNLSKDLMK-EKAQLEKTIETLRENSERQIKILEQENEHLNQTV--SSLRQRS 574
Query: 89 DDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLE---ERKEELEEVAHEL 145
S ++ +K+ L ++ S++ + E++ K+ LE E+ E EE+ +EL
Sbjct: 575 QISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENEL 634
Query: 146 AETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALK 205
E EN +L+ I +K T + + L+QE E E + K + + K
Sbjct: 635 HHLEKENELLQKKITNLK----ITCEKIEALEQENS-------ELERENRKLKKTLDSFK 683
Query: 206 DTIGKLKT-EKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLME 264
+ +L++ EK+ + D L ++ + K ++ + L + E KE ++ +E
Sbjct: 684 NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESE-KEQLKKGLE 742
Query: 265 QQGALLKRLAEA-------DSEKARLLLLLQDKDKEVEEL---LQEIQCE---------- 304
A K+ D E RL L++ +K++++L LQ+++ E
Sbjct: 743 LLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEE 802
Query: 305 -KAQAKTASEL---SKSMESMRGHLQAQLRSKEAENSRLCMQ--------------IKNL 346
K +K +L +KS+E L+ + E EN RL Q I NL
Sbjct: 803 LKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNL 862
Query: 347 ERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKA-------------IRAQKERAEKSE 393
E+ E+ E LK+ +KE +K+A + ++K + ++
Sbjct: 863 EKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMN 922
Query: 394 EYAEQLHVQL----ADKDLYVAEALSTLES----WRSRYNQVVKEKGDL-ELEIIVLNDR 444
E+L +L +K+ + + ST +S S+ +K+ ++ E +I L R
Sbjct: 923 NDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEAR 982
Query: 445 VTDLVNQQQTLEE------------KMREDRDSLVERLHRQTAEYSAFKLENERLKASFA 492
+ + N Q L + K R+D + +V+ + E + ++ E++
Sbjct: 983 LEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELL 1042
Query: 493 PMEDKL-----NQAHL--EVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDK 545
++D+L N A L E Q LK +K E +N ++Q++ + + + Q
Sbjct: 1043 KVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQT 1102
Query: 546 ENKILKDEMNKEIEAARRQFQSQLADLQ-QLPDILKITEAKLAECQDQLQGYERKNIDLT 604
+N L+ E N + + +Q A L Q + E+ + E +D Y+
Sbjct: 1103 QNAKLQVE-NSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYD------- 1154
Query: 605 AIISD---LRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQ--NIEF 659
++I D L E Q + E KH + +K L ++ +LE + Q +E
Sbjct: 1155 SLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLED 1214
Query: 660 LQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSKERAAQNK 719
L+ + K + Q ++ LE K E T+A + + + R + T L + Q
Sbjct: 1215 LEKMLK----VEQEKMLLENKNHE--TVAAEYKKLCGENDR-LNHTYSQLLKETEVLQTD 1267
Query: 720 ILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSS 779
+L++ L+ +K E ++L ++ LK++ +Q + T+ + N + L
Sbjct: 1268 HKNLKSLLNNSKLEQTRL-----------EAEFSKLKEQYQQLDITSTKLNNQCELLSQL 1316
Query: 780 YANV 783
N+
Sbjct: 1317 KGNL 1320
Score = 91.7 bits (226), Expect = 2e-18
Identities = 135/665 (20%), Positives = 286/665 (43%), Gaps = 78/665 (11%)
Query: 123 ERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKEC 182
E Q ++ LE ++++++ EL + E EN L+ N+E +K + + + L++E +
Sbjct: 764 ENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELK----ISSKRLEQLEKENKS 819
Query: 183 LMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEET 242
L + + E D K+ L+ T + I L ++ + L +++ ++E+
Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKES 879
Query: 243 NRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEEL----L 298
L++L +E KE +R L+ + SEK + + D +K EL L
Sbjct: 880 CVRLKELEKEN--KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGL 937
Query: 299 QEIQCEKAQAKTASELSKSMES-MRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEV 357
+ + + T K +ES + L+ L KE + + L +++ Q + E+
Sbjct: 938 NKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQEL 997
Query: 358 EAIMEQLKELKQKGDRDKE-SLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALST 416
+ + + + LKQ+ D ++ I + + E+ + + +++ D+ + V +T
Sbjct: 998 KTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1057
Query: 417 LES----WRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEE---KMREDRDSLVER 469
L++ +++ Q+ + +L+ +I+ L + L Q TL+ K++ + +L
Sbjct: 1058 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTL--- 1114
Query: 470 LHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKT 529
++ ++ +N +L + +E++ E + LK+ Y+ +I +++ +
Sbjct: 1115 ----NSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSL---YDSLIKDHEKLELLH 1167
Query: 530 RLEADEVAAQLER---CDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKL 586
+A E + + + +K L+ E ++++E Q Q L+ L +LK+ + K+
Sbjct: 1168 ERQASEYESLISKHGTLKSAHKNLEVE-HRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKM 1226
Query: 587 AECQDQLQGYERKNIDLTAI----ISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKV 642
E KN + A + R+ H +L E Q K K L L
Sbjct: 1227 L--------LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSL-LNN 1277
Query: 643 DELER-KLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQ 701
+LE+ +LEA EF +K +E Q + + +C L+ QL+ +E+ R
Sbjct: 1278 SKLEQTRLEA------EF----SKLKEQYQQLDITSTKLNNQCELLS-QLKGNLEEENR- 1325
Query: 702 VEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRD---DADRRYQSRLQDLKDR 758
H L + ++T + + +T L Q S+D R+Y +L +L+ +
Sbjct: 1326 ------HLLDQ----------IQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQ 1369
Query: 759 LEQSE 763
E+ E
Sbjct: 1370 KEKLE 1374
Score = 82.4 bits (202), Expect = 2e-15
Identities = 126/534 (23%), Positives = 228/534 (42%), Gaps = 76/534 (14%)
Query: 256 KEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELS 315
+ED E L++ LKRL + E + ++ L ++ + L AQ+ S
Sbjct: 183 QEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHA--SSSAQSPCGSPGM 240
Query: 316 KSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDK 375
K ES R HL +L +A+ RL +++ K E+E + +LK L+Q
Sbjct: 241 KRTES-RQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQ------ 293
Query: 376 ESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLE 435
E++ A+ R + E L++ R + +V K LE
Sbjct: 294 ENMNLLSDARSARMYRDE-----------------------LDALREKAVRVDK----LE 326
Query: 436 LEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPME 495
E+ +R+ D+ + +EE ++ED L+E T +LE R ++
Sbjct: 327 SEVSRYKERLHDIEFYKARVEE-LKEDNQVLLE-----TKTMLEDQLEGTRARS------ 374
Query: 496 DKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMN 555
DKL++ E QLKA + + E D + ++ E E LE K++ +
Sbjct: 375 DKLHELEKENLQLKAKLHDMEMERDMDRKKIE----ELMEENMTLEMAQKQSMDESLHLG 430
Query: 556 KEIEAARRQFQSQLADLQQL-PDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRI 614
E+E R + A + L ++ ++T ++L + E +N LT + +LR+ +
Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELTSSRLLK-------LEMENQSLTKTVEELRTTV 483
Query: 615 EHQGDKLEMAREKHQASQKENKQLSLKVDELERKL--EATSAQNIEFLQVIAKREEAIHQ 672
D +E K +KEN++LS KV+ LE ++ E S QN + L +E+A +
Sbjct: 484 ----DSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLE 539
Query: 673 SQLRL--EEKTRECGTLARQLE--SAIEDARRQVEQTKEHALSKERAAQNKIL-----DL 723
+ E R+ L ++ E + + RQ Q A K+ +NKIL +
Sbjct: 540 KTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKET 599
Query: 724 ETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLK 777
++LS+ + E Q+++ + + + R ++L++ L E N +Q + LK
Sbjct: 600 SSKLSKIEFEKRQIKKELEHYKEKGE-RAEELENELHHLEKENELLQKKITNLK 652
Score = 41.2 bits (95), Expect = 0.004
Identities = 70/309 (22%), Positives = 121/309 (39%), Gaps = 58/309 (18%)
Query: 27 LPKPSATSSQKSHKRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLST 86
L + + T ++ K ++ T+N +S + +N ++ + +E + DL +
Sbjct: 1093 LQEQNTTLQTQNAKLQVENSTLN-SQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKS 1151
Query: 87 EDDD--SGHCKMN----RYDKKIDSLMNAVGCLKSEVK-----------------MQKGE 123
D H K+ R + +SL++ G LKS K QKG+
Sbjct: 1152 LYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQ 1211
Query: 124 RQMAKRFL--EERKEELEEVAHELAETEH-----ENTVLRHNIERMKEEKDFTILQKKHL 176
+ ++ L E+ K LE HE E+ EN L H ++ +E + +LQ H
Sbjct: 1212 LEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETE--VLQTDHK 1269
Query: 177 QQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKL 236
+ SKL + ++ KLK + Q L Q ELL Q
Sbjct: 1270 NLKSLLNNSKLEQTRLEAE------------FSKLKEQYQQLDITSTKLNNQCELLSQLK 1317
Query: 237 STFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADS----EKARLLLLLQDKDK 292
EE NR L D + + LM Q LL++ E+ E+ + + L + +
Sbjct: 1318 GNLEEENRHLLDQI---------QTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRR 1368
Query: 293 EVEELLQEI 301
+ E+L ++I
Sbjct: 1369 QKEKLEEKI 1377
Score = 35.4 bits (80), Expect = 0.21
Identities = 73/332 (21%), Positives = 127/332 (38%), Gaps = 62/332 (18%)
Query: 116 EVKMQKGERQMAKRFLEERKEELEEVAHEL-----------AETEHENTVLRHNIERMKE 164
EV+ Q K+ L+ + ++LE + L + +NT L+ +++
Sbjct: 1050 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1109
Query: 165 EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIG-------KLKTEKQM 217
E Q L + L+ + E + + K+ LK KL+ +
Sbjct: 1110 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHER 1169
Query: 218 TCTDINTLTRQKELLLQKLSTFEETNRTLRD----LLREQHCKEDSERLM--EQQGALLK 271
++ +L + L E +R L D LL+++ ED E+++ EQ+ LL+
Sbjct: 1170 QASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLE 1229
Query: 272 -------------------RLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTAS 312
RL S+ + +LQ K ++ LL + E Q + +
Sbjct: 1230 NKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE--QTRLEA 1287
Query: 313 ELSKSME--------SMRGHLQAQLRSK-----EAENSRLCMQIKNLERSGNQHKAEVEA 359
E SK E S + + Q +L S+ E EN L QI+ L Q++ +E
Sbjct: 1288 EFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLML---QNRTLLEQ 1344
Query: 360 IMEQLKELKQKGDRDKESLKKAIRAQKERAEK 391
ME K+L R +R QKE+ E+
Sbjct: 1345 NMES-KDLFHVEQRQYIDKLNELRRQKEKLEE 1375
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 119 bits (297), Expect = 1e-26
Identities = 160/728 (21%), Positives = 316/728 (43%), Gaps = 102/728 (14%)
Query: 124 RQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECL 183
R+ + LE +K +E+ + + E E L+ + E+ K L+ ++ E
Sbjct: 1899 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1958
Query: 184 MSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETN 243
+ +AE++ AA ++ +A ++ + + E+++ +L ++E Q+ + EE
Sbjct: 1959 LRSKEQAELE--AARQRQLAAEEERRRREAEERVQ----KSLAAEEEAARQRKAALEEVE 2012
Query: 244 RTLRDL-----LREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELL 298
R + LRE+ +E + +L Q A KRL + A +Q K++E+++ L
Sbjct: 2013 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA---FAVQQKEQELQQTL 2069
Query: 299 QEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGN---QHKA 355
Q+ Q Q + +E ++ + Q + A++ R + + L++S Q +A
Sbjct: 2070 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2129
Query: 356 EVEAIMEQL-KELKQKGDRDKESLKKAIRAQKERA----EKSEEYAEQLHVQLADKDLYV 410
+ +A E+L KE +Q+ R ++ + A+R QK+ A EK +++AEQ Q A V
Sbjct: 2130 QAQAAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEMEKHKKFAEQTLRQKAQ----V 2184
Query: 411 AEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKM---REDRDSLV 467
+ L+TL R + + +K L+ E+ L T+ Q+ +EE++ R + L
Sbjct: 2185 EQELTTL---RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2241
Query: 468 ERLHRQTAEYSAFKLENERLKASFAPME-DKLNQAHLEVQQLKASVKN------------ 514
+ R AE A L ++ F E +K+ Q E +L + +
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2301
Query: 515 --YEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADL 572
+ + + M+ EA + A+ E ++ K L E + ++ + Q QLA+
Sbjct: 2302 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ-KELAQEQARRLQEDKEQMAQQLAEE 2360
Query: 573 QQ------------------LPDILKITEAKLAECQ------------------DQLQGY 596
Q + LK+ A+++ Q ++L
Sbjct: 2361 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2420
Query: 597 E---RKNIDLTAIISDLRSRIEHQGDKL-----EMAREKHQASQKENKQLSLKVDEL--- 645
E ++ + L + R + +H ++L E+ REK + Q+E K L LK +E+
Sbjct: 2421 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL-QQEAKLLQLKSEEMQTV 2479
Query: 646 --ERKLEATSAQNIEFLQV---IAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARR 700
E+ L+ T A FL + +RE I Q + +LE+ ++ A+QL + ++
Sbjct: 2480 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2539
Query: 701 QVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLE 760
Q+EQ ++ ++ A+ + + E + R + EL QL + R + Q L+++L+
Sbjct: 2540 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599
Query: 761 QSESTNRS 768
E +R+
Sbjct: 2600 LLEEQHRA 2607
Score = 107 bits (268), Expect = 3e-23
Identities = 157/692 (22%), Positives = 303/692 (43%), Gaps = 80/692 (11%)
Query: 119 MQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQ 178
M + Q + L + + LEE+ + E + I +K+ + + K L+
Sbjct: 1236 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1295
Query: 179 EKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQK-ELLLQKLS 237
+ A +V + +++ + + + +++ TLT Q + + + L
Sbjct: 1296 -------------VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1342
Query: 238 TFEETNRTLRDLLREQHCKEDSERLMEQQGALLKR--LAEADSEKARLLLLLQDKDKEVE 295
EE R L EQ E+ ERL E + AL K+ LAEA ++ ++E +
Sbjct: 1343 RMEEEER-----LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA------QAEREAK 1391
Query: 296 ELLQEIQCEKAQAKTAS-ELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHK 354
EL Q +Q E + + A+ + + S++ LQ +S EAE Q + ERS + +
Sbjct: 1392 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1451
Query: 355 AEVEAIMEQLKEL-KQKGDRDKESLKKAIRAQKERAE----KSEEYAEQLHVQLADKDLY 409
E+ + QL+ +Q+G + E +A+RA+ E AE +++E AE+L Q+ D+
Sbjct: 1452 EEIRVVRLQLEATERQRGGAEGEL--QALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509
Query: 410 VAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVER 469
+A L S + +EK + L + EE R R + VER
Sbjct: 1510 KRQAEVELASRVKAEAEAAREK----------QRALQALEELRLQAEEAERRLRQAEVER 1559
Query: 470 LHR-----QTAEYSAFKLENERLKASFAP----MEDKLNQAHLEVQQLKASVKNY----- 515
+ +TA+ SA + E + +ASFA +E L + H+ V QL+ +
Sbjct: 1560 ARQVQVALETAQRSA-EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1618
Query: 516 --EGMIDNYKSQVMKTRLEADE---VAAQLERCDKENKILKDEMNKEIEAARRQFQSQLA 570
E + + ++ + +L+A+E + Q E ++ + + E K+ E A R+ + +
Sbjct: 1619 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1678
Query: 571 DLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQA 630
+Q ++ E +L + + +G ++ + + LR+ E + ++ E+
Sbjct: 1679 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1738
Query: 631 SQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREE----AIHQSQLRLEEKT---RE 683
Q+E + K ELE +L A+ L A+ EE +S+ RLE + RE
Sbjct: 1739 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1798
Query: 684 CGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLET----QLSRTKTELSQLRR 739
A +L + E+A+RQ + +E A +++RA ++L + + +R KTE +
Sbjct: 1799 LAEEAARLRALAEEAKRQRQLAEEDA-ARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1857
Query: 740 SRDDADRRYQSRLQD---LKDRLEQSESTNRS 768
++ + R + +D + RLE+ + +++
Sbjct: 1858 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1889
Score = 104 bits (260), Expect = 3e-22
Identities = 159/760 (20%), Positives = 317/760 (41%), Gaps = 106/760 (13%)
Query: 114 KSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQK 173
++E++ + + + A+R +EE+ V +L TE + ++ ++ + QK
Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1489
Query: 174 KHLQQEKECL-----------------MSKLVEAEMDGAAAAKQVMALKDTIGKLKTEK- 215
+ Q+E E L ++ V+AE + A ++ + + + +L+ E+
Sbjct: 1490 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-RLQAEEA 1548
Query: 216 ------------QMTCTDINTLTRQKELLLQ-KLSTFEETNRTLRDLLREQH-----CKE 257
+ + T R E LQ K ++F E L L+E+H +E
Sbjct: 1549 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1608
Query: 258 DSERLMEQQGALLKRLAEADSEKARLLLLLQDKDK---EVEELLQEIQCEKAQAKTASEL 314
++ER +QQ + EA+ E R L + + + EE+ Q+ +A+A+ E
Sbjct: 1609 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1668
Query: 315 SKSMESMRGHLQAQ-LRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDR 373
++ RG + Q +R +E L Q + L Q + E + +L+ ++G++
Sbjct: 1669 AEREARRRGKAEEQAVRQRELAEQELEKQ-RQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1727
Query: 374 DKESLKKAI-RAQKERAEKSEEYAE----------QLHVQLADKDLYVAEALSTLESWRS 422
++ L++ + R Q+E A +++ E ++ V LA K E+ ST E +
Sbjct: 1728 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1787
Query: 423 RYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKL 482
R +L E L + Q+Q EE R R AE A
Sbjct: 1788 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR----AEAERVLAEKLAAIG 1843
Query: 483 ENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLER 542
E RLK E L + E ++L+ ++ + Q + + + +E AQL +
Sbjct: 1844 EATRLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1900
Query: 543 C-----DKENKILKD------EMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQD 591
+++ +++D ++ +EI A + F+ A +L L++ + + +D
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE--LELGRIR-SNAED 1957
Query: 592 QLQGYERKNIDLT-----AIISDLRSRIEHQGDKLEMAREKHQASQK-----ENKQLSLK 641
L+ E+ ++ A + R R + + +A E+ A Q+ E ++L K
Sbjct: 1958 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017
Query: 642 VDE---LERKLEATSAQNIEFLQVIAKR----EE-----AIHQSQLRLEEKTRECGTLAR 689
V+E L + E SA+ ++ Q A++ EE A+ Q + L++ ++ ++
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2077
Query: 690 QLESAIEDARRQVEQTKEHALSKERAAQNKILDLE--TQLSRTKTELSQLR--------R 739
QL E ARR E+ +E + ER A +E +L ++ E +Q R +
Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137
Query: 740 SRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSS 779
R +A++ R Q + L Q ++ + M+ + +F + +
Sbjct: 2138 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2177
Score = 84.0 bits (206), Expect = 5e-16
Identities = 149/764 (19%), Positives = 310/764 (40%), Gaps = 126/764 (16%)
Query: 109 AVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKE---- 164
A L+SE+++ G+ + + E+L+ ++ + T+ VLR + E++KE
Sbjct: 1059 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1118
Query: 165 -------EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAA------------KQVMALK 205
E L+K Q E + + E+ GA +V +
Sbjct: 1119 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1178
Query: 206 DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQ 265
+ + +L Q + R+ E L ++L + E+ L L +D+ R EQ
Sbjct: 1179 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL------QDARRRQEQ 1232
Query: 266 QGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHL 325
++ + ADS+ R ++ ++ + LL+EI+ + + +K +
Sbjct: 1233 ----IQAMPLADSQAVR------EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1282
Query: 326 QAQLRSKEAENSRLCMQIKNLE-RSGNQ-----------HKAEVEAIMEQLKELKQKGDR 373
+ QL + +A+ + K + +SG++ H +E+ + Q + + R
Sbjct: 1283 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1342
Query: 374 DKESLKKAIRAQKERAEKSEEYAEQLHVQLA-DKDLYVAEALSTLESWRSRYNQVVKEKG 432
E ++ A+++RAE+ E AE V+ A +K +AEA + ++ R + ++++
Sbjct: 1343 RMEEEERL--AEQQRAEERERLAE---VEAALEKQRQLAEAHAQAKAQAEREAKELQQR- 1396
Query: 433 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERL-----HRQTAEYSAFKLENE-- 485
++ E++ + D Q+++++E++++ R S + + AE S ++E E
Sbjct: 1397 -MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455
Query: 486 RLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLE------------- 532
++ E + A E+Q L+A + E + + + R +
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515
Query: 533 --ADEVAAQLERCDKENKILK--DEMNKEIEAARRQF-QSQLADLQQLPDILKITEAKL- 586
A V A+ E ++ + L+ +E+ + E A R+ Q+++ +Q+ L+ +
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Query: 587 AECQDQLQGYERKNIDLT-------AIISDLRSRIEHQGDKLEMAREKHQASQKENKQLS 639
AE Q + + K L ++ LR E + + A + +++E ++
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635
Query: 640 LKVDE-LERKLEATS-AQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQL-ESAIE 696
LK +E L +L+A AQ Q A++++ + + R K E R+L E +E
Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1695
Query: 697 DARRQVEQTKEHALSKER-------------------------------AAQNKILDLET 725
R+ E T + L+ E+ AA K +LE
Sbjct: 1696 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1755
Query: 726 QLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSM 769
+L++ + E+ L S+ A+ +S + K RLE R +
Sbjct: 1756 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1799
Score = 65.1 bits (157), Expect = 3e-10
Identities = 100/504 (19%), Positives = 204/504 (40%), Gaps = 107/504 (21%)
Query: 113 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEH----ENTVLRHNIERMKEEKDF 168
LK + Q R A+ E+ ++E E+ A A+ E + +E+ K+ +
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 169 TILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQ 228
T+ QK ++QE L +L E + +++ LK + ++ ++ ++ Q
Sbjct: 2177 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236
Query: 229 KELLLQKLSTFEETNRTLRDLLREQH-----CKEDSERLME------------QQGALLK 271
E L + + E NR L +LR++ +E++E++ + Q+ A L+
Sbjct: 2237 MEELSKLKARIEAENRAL--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2294
Query: 272 RLAEADSEKARLLL--LLQDKDKEVEE---LLQEIQCEKAQAKTASELSKSMESMRGHLQ 326
+LAE D + R L +L++K + V+E L E + + Q + A E ++ ++ + +
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2354
Query: 327 AQL--------RSKEAENSRLC--------MQIKNLERSGNQHKAEVEA----------- 359
QL R+ EAE R ++++ E S Q +AE +A
Sbjct: 2355 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2414
Query: 360 ---------------IMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHV--- 401
+++ L+ +Q+ D D E L++AI + EK ++ A+ L +
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2474
Query: 402 --QLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTL---- 455
Q ++ + E + +S+ S + +++ + +E E L D V + Q L
Sbjct: 2475 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2534
Query: 456 ----------------------------EEKMREDRDSLVERLHRQTAEYSAFKLENERL 487
EE +R ++ L + ++ + EN+RL
Sbjct: 2535 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2594
Query: 488 KASFAPMEDKLNQAHLEVQQLKAS 511
+ +E++ A +++ AS
Sbjct: 2595 REQLQLLEEQHRAALAHSEEVTAS 2618
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 119 bits (297), Expect = 1e-26
Identities = 160/728 (21%), Positives = 316/728 (43%), Gaps = 102/728 (14%)
Query: 124 RQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECL 183
R+ + LE +K +E+ + + E E L+ + E+ K L+ ++ E
Sbjct: 1903 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1962
Query: 184 MSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETN 243
+ +AE++ AA ++ +A ++ + + E+++ +L ++E Q+ + EE
Sbjct: 1963 LRSKEQAELE--AARQRQLAAEEERRRREAEERVQ----KSLAAEEEAARQRKAALEEVE 2016
Query: 244 RTLRDL-----LREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELL 298
R + LRE+ +E + +L Q A KRL + A +Q K++E+++ L
Sbjct: 2017 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA---FAVQQKEQELQQTL 2073
Query: 299 QEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGN---QHKA 355
Q+ Q Q + +E ++ + Q + A++ R + + L++S Q +A
Sbjct: 2074 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2133
Query: 356 EVEAIMEQL-KELKQKGDRDKESLKKAIRAQKERA----EKSEEYAEQLHVQLADKDLYV 410
+ +A E+L KE +Q+ R ++ + A+R QK+ A EK +++AEQ Q A V
Sbjct: 2134 QAQAAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEMEKHKKFAEQTLRQKAQ----V 2188
Query: 411 AEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKM---REDRDSLV 467
+ L+TL R + + +K L+ E+ L T+ Q+ +EE++ R + L
Sbjct: 2189 EQELTTL---RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2245
Query: 468 ERLHRQTAEYSAFKLENERLKASFAPME-DKLNQAHLEVQQLKASVKN------------ 514
+ R AE A L ++ F E +K+ Q E +L + +
Sbjct: 2246 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2305
Query: 515 --YEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADL 572
+ + + M+ EA + A+ E ++ K L E + ++ + Q QLA+
Sbjct: 2306 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ-KELAQEQARRLQEDKEQMAQQLAEE 2364
Query: 573 QQ------------------LPDILKITEAKLAECQ------------------DQLQGY 596
Q + LK+ A+++ Q ++L
Sbjct: 2365 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2424
Query: 597 E---RKNIDLTAIISDLRSRIEHQGDKL-----EMAREKHQASQKENKQLSLKVDEL--- 645
E ++ + L + R + +H ++L E+ REK + Q+E K L LK +E+
Sbjct: 2425 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL-QQEAKLLQLKSEEMQTV 2483
Query: 646 --ERKLEATSAQNIEFLQV---IAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARR 700
E+ L+ T A FL + +RE I Q + +LE+ ++ A+QL + ++
Sbjct: 2484 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2543
Query: 701 QVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLE 760
Q+EQ ++ ++ A+ + + E + R + EL QL + R + Q L+++L+
Sbjct: 2544 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2603
Query: 761 QSESTNRS 768
E +R+
Sbjct: 2604 LLEEQHRA 2611
Score = 107 bits (268), Expect = 3e-23
Identities = 157/692 (22%), Positives = 303/692 (43%), Gaps = 80/692 (11%)
Query: 119 MQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQ 178
M + Q + L + + LEE+ + E + I +K+ + + K L+
Sbjct: 1240 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1299
Query: 179 EKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQK-ELLLQKLS 237
+ A +V + +++ + + + +++ TLT Q + + + L
Sbjct: 1300 -------------VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1346
Query: 238 TFEETNRTLRDLLREQHCKEDSERLMEQQGALLKR--LAEADSEKARLLLLLQDKDKEVE 295
EE R L EQ E+ ERL E + AL K+ LAEA ++ ++E +
Sbjct: 1347 RMEEEER-----LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA------QAEREAK 1395
Query: 296 ELLQEIQCEKAQAKTAS-ELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHK 354
EL Q +Q E + + A+ + + S++ LQ +S EAE Q + ERS + +
Sbjct: 1396 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1455
Query: 355 AEVEAIMEQLKEL-KQKGDRDKESLKKAIRAQKERAE----KSEEYAEQLHVQLADKDLY 409
E+ + QL+ +Q+G + E +A+RA+ E AE +++E AE+L Q+ D+
Sbjct: 1456 EEIRVVRLQLEATERQRGGAEGEL--QALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1513
Query: 410 VAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVER 469
+A L S + +EK + L + EE R R + VER
Sbjct: 1514 KRQAEVELASRVKAEAEAAREK----------QRALQALEELRLQAEEAERRLRQAEVER 1563
Query: 470 LHR-----QTAEYSAFKLENERLKASFAP----MEDKLNQAHLEVQQLKASVKNY----- 515
+ +TA+ SA + E + +ASFA +E L + H+ V QL+ +
Sbjct: 1564 ARQVQVALETAQRSA-EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1622
Query: 516 --EGMIDNYKSQVMKTRLEADE---VAAQLERCDKENKILKDEMNKEIEAARRQFQSQLA 570
E + + ++ + +L+A+E + Q E ++ + + E K+ E A R+ + +
Sbjct: 1623 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1682
Query: 571 DLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQA 630
+Q ++ E +L + + +G ++ + + LR+ E + ++ E+
Sbjct: 1683 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1742
Query: 631 SQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREE----AIHQSQLRLEEKT---RE 683
Q+E + K ELE +L A+ L A+ EE +S+ RLE + RE
Sbjct: 1743 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1802
Query: 684 CGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLET----QLSRTKTELSQLRR 739
A +L + E+A+RQ + +E A +++RA ++L + + +R KTE +
Sbjct: 1803 LAEEAARLRALAEEAKRQRQLAEEDA-ARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1861
Query: 740 SRDDADRRYQSRLQD---LKDRLEQSESTNRS 768
++ + R + +D + RLE+ + +++
Sbjct: 1862 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1893
Score = 104 bits (260), Expect = 3e-22
Identities = 159/760 (20%), Positives = 317/760 (41%), Gaps = 106/760 (13%)
Query: 114 KSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQK 173
++E++ + + + A+R +EE+ V +L TE + ++ ++ + QK
Sbjct: 1434 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1493
Query: 174 KHLQQEKECL-----------------MSKLVEAEMDGAAAAKQVMALKDTIGKLKTEK- 215
+ Q+E E L ++ V+AE + A ++ + + + +L+ E+
Sbjct: 1494 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-RLQAEEA 1552
Query: 216 ------------QMTCTDINTLTRQKELLLQ-KLSTFEETNRTLRDLLREQH-----CKE 257
+ + T R E LQ K ++F E L L+E+H +E
Sbjct: 1553 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1612
Query: 258 DSERLMEQQGALLKRLAEADSEKARLLLLLQDKDK---EVEELLQEIQCEKAQAKTASEL 314
++ER +QQ + EA+ E R L + + + EE+ Q+ +A+A+ E
Sbjct: 1613 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1672
Query: 315 SKSMESMRGHLQAQ-LRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDR 373
++ RG + Q +R +E L Q + L Q + E + +L+ ++G++
Sbjct: 1673 AEREARRRGKAEEQAVRQRELAEQELEKQ-RQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1731
Query: 374 DKESLKKAI-RAQKERAEKSEEYAE----------QLHVQLADKDLYVAEALSTLESWRS 422
++ L++ + R Q+E A +++ E ++ V LA K E+ ST E +
Sbjct: 1732 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1791
Query: 423 RYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKL 482
R +L E L + Q+Q EE R R AE A
Sbjct: 1792 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR----AEAERVLAEKLAAIG 1847
Query: 483 ENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLER 542
E RLK E L + E ++L+ ++ + Q + + + +E AQL +
Sbjct: 1848 EATRLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1904
Query: 543 C-----DKENKILKD------EMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQD 591
+++ +++D ++ +EI A + F+ A +L L++ + + +D
Sbjct: 1905 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE--LELGRIR-SNAED 1961
Query: 592 QLQGYERKNIDLT-----AIISDLRSRIEHQGDKLEMAREKHQASQK-----ENKQLSLK 641
L+ E+ ++ A + R R + + +A E+ A Q+ E ++L K
Sbjct: 1962 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2021
Query: 642 VDE---LERKLEATSAQNIEFLQVIAKR----EE-----AIHQSQLRLEEKTRECGTLAR 689
V+E L + E SA+ ++ Q A++ EE A+ Q + L++ ++ ++
Sbjct: 2022 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2081
Query: 690 QLESAIEDARRQVEQTKEHALSKERAAQNKILDLE--TQLSRTKTELSQLR--------R 739
QL E ARR E+ +E + ER A +E +L ++ E +Q R +
Sbjct: 2082 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2141
Query: 740 SRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSS 779
R +A++ R Q + L Q ++ + M+ + +F + +
Sbjct: 2142 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2181
Score = 84.0 bits (206), Expect = 5e-16
Identities = 149/764 (19%), Positives = 310/764 (40%), Gaps = 126/764 (16%)
Query: 109 AVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKE---- 164
A L+SE+++ G+ + + E+L+ ++ + T+ VLR + E++KE
Sbjct: 1063 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1122
Query: 165 -------EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAA------------KQVMALK 205
E L+K Q E + + E+ GA +V +
Sbjct: 1123 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1182
Query: 206 DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQ 265
+ + +L Q + R+ E L ++L + E+ L L +D+ R EQ
Sbjct: 1183 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL------QDARRRQEQ 1236
Query: 266 QGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHL 325
++ + ADS+ R ++ ++ + LL+EI+ + + +K +
Sbjct: 1237 ----IQAMPLADSQAVR------EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1286
Query: 326 QAQLRSKEAENSRLCMQIKNLE-RSGNQ-----------HKAEVEAIMEQLKELKQKGDR 373
+ QL + +A+ + K + +SG++ H +E+ + Q + + R
Sbjct: 1287 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1346
Query: 374 DKESLKKAIRAQKERAEKSEEYAEQLHVQLA-DKDLYVAEALSTLESWRSRYNQVVKEKG 432
E ++ A+++RAE+ E AE V+ A +K +AEA + ++ R + ++++
Sbjct: 1347 RMEEEERL--AEQQRAEERERLAE---VEAALEKQRQLAEAHAQAKAQAEREAKELQQR- 1400
Query: 433 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERL-----HRQTAEYSAFKLENE-- 485
++ E++ + D Q+++++E++++ R S + + AE S ++E E
Sbjct: 1401 -MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1459
Query: 486 RLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLE------------- 532
++ E + A E+Q L+A + E + + + R +
Sbjct: 1460 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1519
Query: 533 --ADEVAAQLERCDKENKILK--DEMNKEIEAARRQF-QSQLADLQQLPDILKITEAKL- 586
A V A+ E ++ + L+ +E+ + E A R+ Q+++ +Q+ L+ +
Sbjct: 1520 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1579
Query: 587 AECQDQLQGYERKNIDLT-------AIISDLRSRIEHQGDKLEMAREKHQASQKENKQLS 639
AE Q + + K L ++ LR E + + A + +++E ++
Sbjct: 1580 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1639
Query: 640 LKVDE-LERKLEATS-AQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQL-ESAIE 696
LK +E L +L+A AQ Q A++++ + + R K E R+L E +E
Sbjct: 1640 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1699
Query: 697 DARRQVEQTKEHALSKER-------------------------------AAQNKILDLET 725
R+ E T + L+ E+ AA K +LE
Sbjct: 1700 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1759
Query: 726 QLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSM 769
+L++ + E+ L S+ A+ +S + K RLE R +
Sbjct: 1760 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1803
Score = 65.1 bits (157), Expect = 3e-10
Identities = 100/504 (19%), Positives = 204/504 (40%), Gaps = 107/504 (21%)
Query: 113 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEH----ENTVLRHNIERMKEEKDF 168
LK + Q R A+ E+ ++E E+ A A+ E + +E+ K+ +
Sbjct: 2121 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2180
Query: 169 TILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQ 228
T+ QK ++QE L +L E + +++ LK + ++ ++ ++ Q
Sbjct: 2181 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2240
Query: 229 KELLLQKLSTFEETNRTLRDLLREQH-----CKEDSERLME------------QQGALLK 271
E L + + E NR L +LR++ +E++E++ + Q+ A L+
Sbjct: 2241 MEELSKLKARIEAENRAL--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2298
Query: 272 RLAEADSEKARLLL--LLQDKDKEVEE---LLQEIQCEKAQAKTASELSKSMESMRGHLQ 326
+LAE D + R L +L++K + V+E L E + + Q + A E ++ ++ + +
Sbjct: 2299 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2358
Query: 327 AQL--------RSKEAENSRLC--------MQIKNLERSGNQHKAEVEA----------- 359
QL R+ EAE R ++++ E S Q +AE +A
Sbjct: 2359 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2418
Query: 360 ---------------IMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHV--- 401
+++ L+ +Q+ D D E L++AI + EK ++ A+ L +
Sbjct: 2419 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2478
Query: 402 --QLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTL---- 455
Q ++ + E + +S+ S + +++ + +E E L D V + Q L
Sbjct: 2479 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2538
Query: 456 ----------------------------EEKMREDRDSLVERLHRQTAEYSAFKLENERL 487
EE +R ++ L + ++ + EN+RL
Sbjct: 2539 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2598
Query: 488 KASFAPMEDKLNQAHLEVQQLKAS 511
+ +E++ A +++ AS
Sbjct: 2599 REQLQLLEEQHRAALAHSEEVTAS 2622
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 119 bits (297), Expect = 1e-26
Identities = 160/728 (21%), Positives = 316/728 (43%), Gaps = 102/728 (14%)
Query: 124 RQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECL 183
R+ + LE +K +E+ + + E E L+ + E+ K L+ ++ E
Sbjct: 1899 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1958
Query: 184 MSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETN 243
+ +AE++ AA ++ +A ++ + + E+++ +L ++E Q+ + EE
Sbjct: 1959 LRSKEQAELE--AARQRQLAAEEERRRREAEERVQ----KSLAAEEEAARQRKAALEEVE 2012
Query: 244 RTLRDL-----LREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELL 298
R + LRE+ +E + +L Q A KRL + A +Q K++E+++ L
Sbjct: 2013 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA---FAVQQKEQELQQTL 2069
Query: 299 QEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGN---QHKA 355
Q+ Q Q + +E ++ + Q + A++ R + + L++S Q +A
Sbjct: 2070 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2129
Query: 356 EVEAIMEQL-KELKQKGDRDKESLKKAIRAQKERA----EKSEEYAEQLHVQLADKDLYV 410
+ +A E+L KE +Q+ R ++ + A+R QK+ A EK +++AEQ Q A V
Sbjct: 2130 QAQAAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEMEKHKKFAEQTLRQKAQ----V 2184
Query: 411 AEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKM---REDRDSLV 467
+ L+TL R + + +K L+ E+ L T+ Q+ +EE++ R + L
Sbjct: 2185 EQELTTL---RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2241
Query: 468 ERLHRQTAEYSAFKLENERLKASFAPME-DKLNQAHLEVQQLKASVKN------------ 514
+ R AE A L ++ F E +K+ Q E +L + +
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2301
Query: 515 --YEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADL 572
+ + + M+ EA + A+ E ++ K L E + ++ + Q QLA+
Sbjct: 2302 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ-KELAQEQARRLQEDKEQMAQQLAEE 2360
Query: 573 QQ------------------LPDILKITEAKLAECQ------------------DQLQGY 596
Q + LK+ A+++ Q ++L
Sbjct: 2361 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2420
Query: 597 E---RKNIDLTAIISDLRSRIEHQGDKL-----EMAREKHQASQKENKQLSLKVDEL--- 645
E ++ + L + R + +H ++L E+ REK + Q+E K L LK +E+
Sbjct: 2421 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL-QQEAKLLQLKSEEMQTV 2479
Query: 646 --ERKLEATSAQNIEFLQV---IAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARR 700
E+ L+ T A FL + +RE I Q + +LE+ ++ A+QL + ++
Sbjct: 2480 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2539
Query: 701 QVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLE 760
Q+EQ ++ ++ A+ + + E + R + EL QL + R + Q L+++L+
Sbjct: 2540 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599
Query: 761 QSESTNRS 768
E +R+
Sbjct: 2600 LLEEQHRA 2607
Score = 107 bits (268), Expect = 3e-23
Identities = 157/692 (22%), Positives = 303/692 (43%), Gaps = 80/692 (11%)
Query: 119 MQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQ 178
M + Q + L + + LEE+ + E + I +K+ + + K L+
Sbjct: 1236 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1295
Query: 179 EKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQK-ELLLQKLS 237
+ A +V + +++ + + + +++ TLT Q + + + L
Sbjct: 1296 -------------VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1342
Query: 238 TFEETNRTLRDLLREQHCKEDSERLMEQQGALLKR--LAEADSEKARLLLLLQDKDKEVE 295
EE R L EQ E+ ERL E + AL K+ LAEA ++ ++E +
Sbjct: 1343 RMEEEER-----LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA------QAEREAK 1391
Query: 296 ELLQEIQCEKAQAKTAS-ELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHK 354
EL Q +Q E + + A+ + + S++ LQ +S EAE Q + ERS + +
Sbjct: 1392 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1451
Query: 355 AEVEAIMEQLKEL-KQKGDRDKESLKKAIRAQKERAE----KSEEYAEQLHVQLADKDLY 409
E+ + QL+ +Q+G + E +A+RA+ E AE +++E AE+L Q+ D+
Sbjct: 1452 EEIRVVRLQLEATERQRGGAEGEL--QALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509
Query: 410 VAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVER 469
+A L S + +EK + L + EE R R + VER
Sbjct: 1510 KRQAEVELASRVKAEAEAAREK----------QRALQALEELRLQAEEAERRLRQAEVER 1559
Query: 470 LHR-----QTAEYSAFKLENERLKASFAP----MEDKLNQAHLEVQQLKASVKNY----- 515
+ +TA+ SA + E + +ASFA +E L + H+ V QL+ +
Sbjct: 1560 ARQVQVALETAQRSA-EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1618
Query: 516 --EGMIDNYKSQVMKTRLEADE---VAAQLERCDKENKILKDEMNKEIEAARRQFQSQLA 570
E + + ++ + +L+A+E + Q E ++ + + E K+ E A R+ + +
Sbjct: 1619 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1678
Query: 571 DLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQA 630
+Q ++ E +L + + +G ++ + + LR+ E + ++ E+
Sbjct: 1679 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1738
Query: 631 SQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREE----AIHQSQLRLEEKT---RE 683
Q+E + K ELE +L A+ L A+ EE +S+ RLE + RE
Sbjct: 1739 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1798
Query: 684 CGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLET----QLSRTKTELSQLRR 739
A +L + E+A+RQ + +E A +++RA ++L + + +R KTE +
Sbjct: 1799 LAEEAARLRALAEEAKRQRQLAEEDA-ARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1857
Query: 740 SRDDADRRYQSRLQD---LKDRLEQSESTNRS 768
++ + R + +D + RLE+ + +++
Sbjct: 1858 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1889
Score = 104 bits (260), Expect = 3e-22
Identities = 159/760 (20%), Positives = 317/760 (41%), Gaps = 106/760 (13%)
Query: 114 KSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQK 173
++E++ + + + A+R +EE+ V +L TE + ++ ++ + QK
Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1489
Query: 174 KHLQQEKECL-----------------MSKLVEAEMDGAAAAKQVMALKDTIGKLKTEK- 215
+ Q+E E L ++ V+AE + A ++ + + + +L+ E+
Sbjct: 1490 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-RLQAEEA 1548
Query: 216 ------------QMTCTDINTLTRQKELLLQ-KLSTFEETNRTLRDLLREQH-----CKE 257
+ + T R E LQ K ++F E L L+E+H +E
Sbjct: 1549 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1608
Query: 258 DSERLMEQQGALLKRLAEADSEKARLLLLLQDKDK---EVEELLQEIQCEKAQAKTASEL 314
++ER +QQ + EA+ E R L + + + EE+ Q+ +A+A+ E
Sbjct: 1609 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1668
Query: 315 SKSMESMRGHLQAQ-LRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDR 373
++ RG + Q +R +E L Q + L Q + E + +L+ ++G++
Sbjct: 1669 AEREARRRGKAEEQAVRQRELAEQELEKQ-RQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1727
Query: 374 DKESLKKAI-RAQKERAEKSEEYAE----------QLHVQLADKDLYVAEALSTLESWRS 422
++ L++ + R Q+E A +++ E ++ V LA K E+ ST E +
Sbjct: 1728 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1787
Query: 423 RYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKL 482
R +L E L + Q+Q EE R R AE A
Sbjct: 1788 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR----AEAERVLAEKLAAIG 1843
Query: 483 ENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLER 542
E RLK E L + E ++L+ ++ + Q + + + +E AQL +
Sbjct: 1844 EATRLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1900
Query: 543 C-----DKENKILKD------EMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQD 591
+++ +++D ++ +EI A + F+ A +L L++ + + +D
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE--LELGRIR-SNAED 1957
Query: 592 QLQGYERKNIDLT-----AIISDLRSRIEHQGDKLEMAREKHQASQK-----ENKQLSLK 641
L+ E+ ++ A + R R + + +A E+ A Q+ E ++L K
Sbjct: 1958 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017
Query: 642 VDE---LERKLEATSAQNIEFLQVIAKR----EE-----AIHQSQLRLEEKTRECGTLAR 689
V+E L + E SA+ ++ Q A++ EE A+ Q + L++ ++ ++
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2077
Query: 690 QLESAIEDARRQVEQTKEHALSKERAAQNKILDLE--TQLSRTKTELSQLR--------R 739
QL E ARR E+ +E + ER A +E +L ++ E +Q R +
Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137
Query: 740 SRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSS 779
R +A++ R Q + L Q ++ + M+ + +F + +
Sbjct: 2138 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2177
Score = 84.0 bits (206), Expect = 5e-16
Identities = 149/764 (19%), Positives = 310/764 (40%), Gaps = 126/764 (16%)
Query: 109 AVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKE---- 164
A L+SE+++ G+ + + E+L+ ++ + T+ VLR + E++KE
Sbjct: 1059 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1118
Query: 165 -------EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAA------------KQVMALK 205
E L+K Q E + + E+ GA +V +
Sbjct: 1119 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1178
Query: 206 DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQ 265
+ + +L Q + R+ E L ++L + E+ L L +D+ R EQ
Sbjct: 1179 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL------QDARRRQEQ 1232
Query: 266 QGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHL 325
++ + ADS+ R ++ ++ + LL+EI+ + + +K +
Sbjct: 1233 ----IQAMPLADSQAVR------EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1282
Query: 326 QAQLRSKEAENSRLCMQIKNLE-RSGNQ-----------HKAEVEAIMEQLKELKQKGDR 373
+ QL + +A+ + K + +SG++ H +E+ + Q + + R
Sbjct: 1283 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1342
Query: 374 DKESLKKAIRAQKERAEKSEEYAEQLHVQLA-DKDLYVAEALSTLESWRSRYNQVVKEKG 432
E ++ A+++RAE+ E AE V+ A +K +AEA + ++ R + ++++
Sbjct: 1343 RMEEEERL--AEQQRAEERERLAE---VEAALEKQRQLAEAHAQAKAQAEREAKELQQR- 1396
Query: 433 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERL-----HRQTAEYSAFKLENE-- 485
++ E++ + D Q+++++E++++ R S + + AE S ++E E
Sbjct: 1397 -MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455
Query: 486 RLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLE------------- 532
++ E + A E+Q L+A + E + + + R +
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515
Query: 533 --ADEVAAQLERCDKENKILK--DEMNKEIEAARRQF-QSQLADLQQLPDILKITEAKL- 586
A V A+ E ++ + L+ +E+ + E A R+ Q+++ +Q+ L+ +
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Query: 587 AECQDQLQGYERKNIDLT-------AIISDLRSRIEHQGDKLEMAREKHQASQKENKQLS 639
AE Q + + K L ++ LR E + + A + +++E ++
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635
Query: 640 LKVDE-LERKLEATS-AQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQL-ESAIE 696
LK +E L +L+A AQ Q A++++ + + R K E R+L E +E
Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1695
Query: 697 DARRQVEQTKEHALSKER-------------------------------AAQNKILDLET 725
R+ E T + L+ E+ AA K +LE
Sbjct: 1696 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1755
Query: 726 QLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSM 769
+L++ + E+ L S+ A+ +S + K RLE R +
Sbjct: 1756 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1799
Score = 65.1 bits (157), Expect = 3e-10
Identities = 100/504 (19%), Positives = 204/504 (40%), Gaps = 107/504 (21%)
Query: 113 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEH----ENTVLRHNIERMKEEKDF 168
LK + Q R A+ E+ ++E E+ A A+ E + +E+ K+ +
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 169 TILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQ 228
T+ QK ++QE L +L E + +++ LK + ++ ++ ++ Q
Sbjct: 2177 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236
Query: 229 KELLLQKLSTFEETNRTLRDLLREQH-----CKEDSERLME------------QQGALLK 271
E L + + E NR L +LR++ +E++E++ + Q+ A L+
Sbjct: 2237 MEELSKLKARIEAENRAL--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2294
Query: 272 RLAEADSEKARLLL--LLQDKDKEVEE---LLQEIQCEKAQAKTASELSKSMESMRGHLQ 326
+LAE D + R L +L++K + V+E L E + + Q + A E ++ ++ + +
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2354
Query: 327 AQL--------RSKEAENSRLC--------MQIKNLERSGNQHKAEVEA----------- 359
QL R+ EAE R ++++ E S Q +AE +A
Sbjct: 2355 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2414
Query: 360 ---------------IMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHV--- 401
+++ L+ +Q+ D D E L++AI + EK ++ A+ L +
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2474
Query: 402 --QLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTL---- 455
Q ++ + E + +S+ S + +++ + +E E L D V + Q L
Sbjct: 2475 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2534
Query: 456 ----------------------------EEKMREDRDSLVERLHRQTAEYSAFKLENERL 487
EE +R ++ L + ++ + EN+RL
Sbjct: 2535 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2594
Query: 488 KASFAPMEDKLNQAHLEVQQLKAS 511
+ +E++ A +++ AS
Sbjct: 2595 REQLQLLEEQHRAALAHSEEVTAS 2618
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 119 bits (297), Expect = 1e-26
Identities = 160/728 (21%), Positives = 316/728 (43%), Gaps = 102/728 (14%)
Query: 124 RQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECL 183
R+ + LE +K +E+ + + E E L+ + E+ K L+ ++ E
Sbjct: 1867 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1926
Query: 184 MSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETN 243
+ +AE++ AA ++ +A ++ + + E+++ +L ++E Q+ + EE
Sbjct: 1927 LRSKEQAELE--AARQRQLAAEEERRRREAEERVQ----KSLAAEEEAARQRKAALEEVE 1980
Query: 244 RTLRDL-----LREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELL 298
R + LRE+ +E + +L Q A KRL + A +Q K++E+++ L
Sbjct: 1981 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA---FAVQQKEQELQQTL 2037
Query: 299 QEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGN---QHKA 355
Q+ Q Q + +E ++ + Q + A++ R + + L++S Q +A
Sbjct: 2038 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2097
Query: 356 EVEAIMEQL-KELKQKGDRDKESLKKAIRAQKERA----EKSEEYAEQLHVQLADKDLYV 410
+ +A E+L KE +Q+ R ++ + A+R QK+ A EK +++AEQ Q A V
Sbjct: 2098 QAQAAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEMEKHKKFAEQTLRQKAQ----V 2152
Query: 411 AEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKM---REDRDSLV 467
+ L+TL R + + +K L+ E+ L T+ Q+ +EE++ R + L
Sbjct: 2153 EQELTTL---RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2209
Query: 468 ERLHRQTAEYSAFKLENERLKASFAPME-DKLNQAHLEVQQLKASVKN------------ 514
+ R AE A L ++ F E +K+ Q E +L + +
Sbjct: 2210 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2269
Query: 515 --YEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADL 572
+ + + M+ EA + A+ E ++ K L E + ++ + Q QLA+
Sbjct: 2270 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ-KELAQEQARRLQEDKEQMAQQLAEE 2328
Query: 573 QQ------------------LPDILKITEAKLAECQ------------------DQLQGY 596
Q + LK+ A+++ Q ++L
Sbjct: 2329 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2388
Query: 597 E---RKNIDLTAIISDLRSRIEHQGDKL-----EMAREKHQASQKENKQLSLKVDEL--- 645
E ++ + L + R + +H ++L E+ REK + Q+E K L LK +E+
Sbjct: 2389 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL-QQEAKLLQLKSEEMQTV 2447
Query: 646 --ERKLEATSAQNIEFLQV---IAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARR 700
E+ L+ T A FL + +RE I Q + +LE+ ++ A+QL + ++
Sbjct: 2448 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2507
Query: 701 QVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLE 760
Q+EQ ++ ++ A+ + + E + R + EL QL + R + Q L+++L+
Sbjct: 2508 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2567
Query: 761 QSESTNRS 768
E +R+
Sbjct: 2568 LLEEQHRA 2575
Score = 107 bits (268), Expect = 3e-23
Identities = 157/692 (22%), Positives = 303/692 (43%), Gaps = 80/692 (11%)
Query: 119 MQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQ 178
M + Q + L + + LEE+ + E + I +K+ + + K L+
Sbjct: 1204 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1263
Query: 179 EKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQK-ELLLQKLS 237
+ A +V + +++ + + + +++ TLT Q + + + L
Sbjct: 1264 -------------VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1310
Query: 238 TFEETNRTLRDLLREQHCKEDSERLMEQQGALLKR--LAEADSEKARLLLLLQDKDKEVE 295
EE R L EQ E+ ERL E + AL K+ LAEA ++ ++E +
Sbjct: 1311 RMEEEER-----LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA------QAEREAK 1359
Query: 296 ELLQEIQCEKAQAKTAS-ELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHK 354
EL Q +Q E + + A+ + + S++ LQ +S EAE Q + ERS + +
Sbjct: 1360 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1419
Query: 355 AEVEAIMEQLKEL-KQKGDRDKESLKKAIRAQKERAE----KSEEYAEQLHVQLADKDLY 409
E+ + QL+ +Q+G + E +A+RA+ E AE +++E AE+L Q+ D+
Sbjct: 1420 EEIRVVRLQLEATERQRGGAEGEL--QALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1477
Query: 410 VAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVER 469
+A L S + +EK + L + EE R R + VER
Sbjct: 1478 KRQAEVELASRVKAEAEAAREK----------QRALQALEELRLQAEEAERRLRQAEVER 1527
Query: 470 LHR-----QTAEYSAFKLENERLKASFAP----MEDKLNQAHLEVQQLKASVKNY----- 515
+ +TA+ SA + E + +ASFA +E L + H+ V QL+ +
Sbjct: 1528 ARQVQVALETAQRSA-EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1586
Query: 516 --EGMIDNYKSQVMKTRLEADE---VAAQLERCDKENKILKDEMNKEIEAARRQFQSQLA 570
E + + ++ + +L+A+E + Q E ++ + + E K+ E A R+ + +
Sbjct: 1587 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1646
Query: 571 DLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQA 630
+Q ++ E +L + + +G ++ + + LR+ E + ++ E+
Sbjct: 1647 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1706
Query: 631 SQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREE----AIHQSQLRLEEKT---RE 683
Q+E + K ELE +L A+ L A+ EE +S+ RLE + RE
Sbjct: 1707 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1766
Query: 684 CGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLET----QLSRTKTELSQLRR 739
A +L + E+A+RQ + +E A +++RA ++L + + +R KTE +
Sbjct: 1767 LAEEAARLRALAEEAKRQRQLAEEDA-ARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1825
Query: 740 SRDDADRRYQSRLQD---LKDRLEQSESTNRS 768
++ + R + +D + RLE+ + +++
Sbjct: 1826 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1857
Score = 104 bits (260), Expect = 3e-22
Identities = 159/760 (20%), Positives = 317/760 (41%), Gaps = 106/760 (13%)
Query: 114 KSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQK 173
++E++ + + + A+R +EE+ V +L TE + ++ ++ + QK
Sbjct: 1398 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1457
Query: 174 KHLQQEKECL-----------------MSKLVEAEMDGAAAAKQVMALKDTIGKLKTEK- 215
+ Q+E E L ++ V+AE + A ++ + + + +L+ E+
Sbjct: 1458 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-RLQAEEA 1516
Query: 216 ------------QMTCTDINTLTRQKELLLQ-KLSTFEETNRTLRDLLREQH-----CKE 257
+ + T R E LQ K ++F E L L+E+H +E
Sbjct: 1517 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1576
Query: 258 DSERLMEQQGALLKRLAEADSEKARLLLLLQDKDK---EVEELLQEIQCEKAQAKTASEL 314
++ER +QQ + EA+ E R L + + + EE+ Q+ +A+A+ E
Sbjct: 1577 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1636
Query: 315 SKSMESMRGHLQAQ-LRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDR 373
++ RG + Q +R +E L Q + L Q + E + +L+ ++G++
Sbjct: 1637 AEREARRRGKAEEQAVRQRELAEQELEKQ-RQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1695
Query: 374 DKESLKKAI-RAQKERAEKSEEYAE----------QLHVQLADKDLYVAEALSTLESWRS 422
++ L++ + R Q+E A +++ E ++ V LA K E+ ST E +
Sbjct: 1696 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1755
Query: 423 RYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKL 482
R +L E L + Q+Q EE R R AE A
Sbjct: 1756 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR----AEAERVLAEKLAAIG 1811
Query: 483 ENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLER 542
E RLK E L + E ++L+ ++ + Q + + + +E AQL +
Sbjct: 1812 EATRLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1868
Query: 543 C-----DKENKILKD------EMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQD 591
+++ +++D ++ +EI A + F+ A +L L++ + + +D
Sbjct: 1869 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE--LELGRIR-SNAED 1925
Query: 592 QLQGYERKNIDLT-----AIISDLRSRIEHQGDKLEMAREKHQASQK-----ENKQLSLK 641
L+ E+ ++ A + R R + + +A E+ A Q+ E ++L K
Sbjct: 1926 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1985
Query: 642 VDE---LERKLEATSAQNIEFLQVIAKR----EE-----AIHQSQLRLEEKTRECGTLAR 689
V+E L + E SA+ ++ Q A++ EE A+ Q + L++ ++ ++
Sbjct: 1986 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2045
Query: 690 QLESAIEDARRQVEQTKEHALSKERAAQNKILDLE--TQLSRTKTELSQLR--------R 739
QL E ARR E+ +E + ER A +E +L ++ E +Q R +
Sbjct: 2046 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2105
Query: 740 SRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSS 779
R +A++ R Q + L Q ++ + M+ + +F + +
Sbjct: 2106 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2145
Score = 84.0 bits (206), Expect = 5e-16
Identities = 149/764 (19%), Positives = 310/764 (40%), Gaps = 126/764 (16%)
Query: 109 AVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKE---- 164
A L+SE+++ G+ + + E+L+ ++ + T+ VLR + E++KE
Sbjct: 1027 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1086
Query: 165 -------EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAA------------KQVMALK 205
E L+K Q E + + E+ GA +V +
Sbjct: 1087 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1146
Query: 206 DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQ 265
+ + +L Q + R+ E L ++L + E+ L L +D+ R EQ
Sbjct: 1147 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL------QDARRRQEQ 1200
Query: 266 QGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHL 325
++ + ADS+ R ++ ++ + LL+EI+ + + +K +
Sbjct: 1201 ----IQAMPLADSQAVR------EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1250
Query: 326 QAQLRSKEAENSRLCMQIKNLE-RSGNQ-----------HKAEVEAIMEQLKELKQKGDR 373
+ QL + +A+ + K + +SG++ H +E+ + Q + + R
Sbjct: 1251 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1310
Query: 374 DKESLKKAIRAQKERAEKSEEYAEQLHVQLA-DKDLYVAEALSTLESWRSRYNQVVKEKG 432
E ++ A+++RAE+ E AE V+ A +K +AEA + ++ R + ++++
Sbjct: 1311 RMEEEERL--AEQQRAEERERLAE---VEAALEKQRQLAEAHAQAKAQAEREAKELQQR- 1364
Query: 433 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERL-----HRQTAEYSAFKLENE-- 485
++ E++ + D Q+++++E++++ R S + + AE S ++E E
Sbjct: 1365 -MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1423
Query: 486 RLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLE------------- 532
++ E + A E+Q L+A + E + + + R +
Sbjct: 1424 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1483
Query: 533 --ADEVAAQLERCDKENKILK--DEMNKEIEAARRQF-QSQLADLQQLPDILKITEAKL- 586
A V A+ E ++ + L+ +E+ + E A R+ Q+++ +Q+ L+ +
Sbjct: 1484 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1543
Query: 587 AECQDQLQGYERKNIDLT-------AIISDLRSRIEHQGDKLEMAREKHQASQKENKQLS 639
AE Q + + K L ++ LR E + + A + +++E ++
Sbjct: 1544 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1603
Query: 640 LKVDE-LERKLEATS-AQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQL-ESAIE 696
LK +E L +L+A AQ Q A++++ + + R K E R+L E +E
Sbjct: 1604 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1663
Query: 697 DARRQVEQTKEHALSKER-------------------------------AAQNKILDLET 725
R+ E T + L+ E+ AA K +LE
Sbjct: 1664 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1723
Query: 726 QLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSM 769
+L++ + E+ L S+ A+ +S + K RLE R +
Sbjct: 1724 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1767
Score = 65.1 bits (157), Expect = 3e-10
Identities = 100/504 (19%), Positives = 204/504 (40%), Gaps = 107/504 (21%)
Query: 113 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEH----ENTVLRHNIERMKEEKDF 168
LK + Q R A+ E+ ++E E+ A A+ E + +E+ K+ +
Sbjct: 2085 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2144
Query: 169 TILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQ 228
T+ QK ++QE L +L E + +++ LK + ++ ++ ++ Q
Sbjct: 2145 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2204
Query: 229 KELLLQKLSTFEETNRTLRDLLREQH-----CKEDSERLME------------QQGALLK 271
E L + + E NR L +LR++ +E++E++ + Q+ A L+
Sbjct: 2205 MEELSKLKARIEAENRAL--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2262
Query: 272 RLAEADSEKARLLL--LLQDKDKEVEE---LLQEIQCEKAQAKTASELSKSMESMRGHLQ 326
+LAE D + R L +L++K + V+E L E + + Q + A E ++ ++ + +
Sbjct: 2263 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2322
Query: 327 AQL--------RSKEAENSRLC--------MQIKNLERSGNQHKAEVEA----------- 359
QL R+ EAE R ++++ E S Q +AE +A
Sbjct: 2323 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2382
Query: 360 ---------------IMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHV--- 401
+++ L+ +Q+ D D E L++AI + EK ++ A+ L +
Sbjct: 2383 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2442
Query: 402 --QLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTL---- 455
Q ++ + E + +S+ S + +++ + +E E L D V + Q L
Sbjct: 2443 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2502
Query: 456 ----------------------------EEKMREDRDSLVERLHRQTAEYSAFKLENERL 487
EE +R ++ L + ++ + EN+RL
Sbjct: 2503 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2562
Query: 488 KASFAPMEDKLNQAHLEVQQLKAS 511
+ +E++ A +++ AS
Sbjct: 2563 REQLQLLEEQHRAALAHSEEVTAS 2586
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 119 bits (297), Expect = 1e-26
Identities = 160/728 (21%), Positives = 316/728 (43%), Gaps = 102/728 (14%)
Query: 124 RQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECL 183
R+ + LE +K +E+ + + E E L+ + E+ K L+ ++ E
Sbjct: 2036 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 2095
Query: 184 MSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETN 243
+ +AE++ AA ++ +A ++ + + E+++ +L ++E Q+ + EE
Sbjct: 2096 LRSKEQAELE--AARQRQLAAEEERRRREAEERVQ----KSLAAEEEAARQRKAALEEVE 2149
Query: 244 RTLRDL-----LREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELL 298
R + LRE+ +E + +L Q A KRL + A +Q K++E+++ L
Sbjct: 2150 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA---FAVQQKEQELQQTL 2206
Query: 299 QEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGN---QHKA 355
Q+ Q Q + +E ++ + Q + A++ R + + L++S Q +A
Sbjct: 2207 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2266
Query: 356 EVEAIMEQL-KELKQKGDRDKESLKKAIRAQKERA----EKSEEYAEQLHVQLADKDLYV 410
+ +A E+L KE +Q+ R ++ + A+R QK+ A EK +++AEQ Q A V
Sbjct: 2267 QAQAAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEMEKHKKFAEQTLRQKAQ----V 2321
Query: 411 AEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKM---REDRDSLV 467
+ L+TL R + + +K L+ E+ L T+ Q+ +EE++ R + L
Sbjct: 2322 EQELTTL---RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2378
Query: 468 ERLHRQTAEYSAFKLENERLKASFAPME-DKLNQAHLEVQQLKASVKN------------ 514
+ R AE A L ++ F E +K+ Q E +L + +
Sbjct: 2379 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2438
Query: 515 --YEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADL 572
+ + + M+ EA + A+ E ++ K L E + ++ + Q QLA+
Sbjct: 2439 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ-KELAQEQARRLQEDKEQMAQQLAEE 2497
Query: 573 QQ------------------LPDILKITEAKLAECQ------------------DQLQGY 596
Q + LK+ A+++ Q ++L
Sbjct: 2498 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2557
Query: 597 E---RKNIDLTAIISDLRSRIEHQGDKL-----EMAREKHQASQKENKQLSLKVDEL--- 645
E ++ + L + R + +H ++L E+ REK + Q+E K L LK +E+
Sbjct: 2558 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL-QQEAKLLQLKSEEMQTV 2616
Query: 646 --ERKLEATSAQNIEFLQV---IAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARR 700
E+ L+ T A FL + +RE I Q + +LE+ ++ A+QL + ++
Sbjct: 2617 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2676
Query: 701 QVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLE 760
Q+EQ ++ ++ A+ + + E + R + EL QL + R + Q L+++L+
Sbjct: 2677 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2736
Query: 761 QSESTNRS 768
E +R+
Sbjct: 2737 LLEEQHRA 2744
Score = 107 bits (268), Expect = 3e-23
Identities = 157/692 (22%), Positives = 303/692 (43%), Gaps = 80/692 (11%)
Query: 119 MQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQ 178
M + Q + L + + LEE+ + E + I +K+ + + K L+
Sbjct: 1373 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1432
Query: 179 EKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQK-ELLLQKLS 237
+ A +V + +++ + + + +++ TLT Q + + + L
Sbjct: 1433 -------------VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1479
Query: 238 TFEETNRTLRDLLREQHCKEDSERLMEQQGALLKR--LAEADSEKARLLLLLQDKDKEVE 295
EE R L EQ E+ ERL E + AL K+ LAEA ++ ++E +
Sbjct: 1480 RMEEEER-----LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA------QAEREAK 1528
Query: 296 ELLQEIQCEKAQAKTAS-ELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHK 354
EL Q +Q E + + A+ + + S++ LQ +S EAE Q + ERS + +
Sbjct: 1529 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1588
Query: 355 AEVEAIMEQLKEL-KQKGDRDKESLKKAIRAQKERAE----KSEEYAEQLHVQLADKDLY 409
E+ + QL+ +Q+G + E +A+RA+ E AE +++E AE+L Q+ D+
Sbjct: 1589 EEIRVVRLQLEATERQRGGAEGEL--QALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1646
Query: 410 VAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVER 469
+A L S + +EK + L + EE R R + VER
Sbjct: 1647 KRQAEVELASRVKAEAEAAREK----------QRALQALEELRLQAEEAERRLRQAEVER 1696
Query: 470 LHR-----QTAEYSAFKLENERLKASFAP----MEDKLNQAHLEVQQLKASVKNY----- 515
+ +TA+ SA + E + +ASFA +E L + H+ V QL+ +
Sbjct: 1697 ARQVQVALETAQRSA-EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1755
Query: 516 --EGMIDNYKSQVMKTRLEADE---VAAQLERCDKENKILKDEMNKEIEAARRQFQSQLA 570
E + + ++ + +L+A+E + Q E ++ + + E K+ E A R+ + +
Sbjct: 1756 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1815
Query: 571 DLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQA 630
+Q ++ E +L + + +G ++ + + LR+ E + ++ E+
Sbjct: 1816 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1875
Query: 631 SQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREE----AIHQSQLRLEEKT---RE 683
Q+E + K ELE +L A+ L A+ EE +S+ RLE + RE
Sbjct: 1876 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1935
Query: 684 CGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLET----QLSRTKTELSQLRR 739
A +L + E+A+RQ + +E A +++RA ++L + + +R KTE +
Sbjct: 1936 LAEEAARLRALAEEAKRQRQLAEEDA-ARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1994
Query: 740 SRDDADRRYQSRLQD---LKDRLEQSESTNRS 768
++ + R + +D + RLE+ + +++
Sbjct: 1995 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 2026
Score = 104 bits (260), Expect = 3e-22
Identities = 159/760 (20%), Positives = 317/760 (41%), Gaps = 106/760 (13%)
Query: 114 KSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQK 173
++E++ + + + A+R +EE+ V +L TE + ++ ++ + QK
Sbjct: 1567 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1626
Query: 174 KHLQQEKECL-----------------MSKLVEAEMDGAAAAKQVMALKDTIGKLKTEK- 215
+ Q+E E L ++ V+AE + A ++ + + + +L+ E+
Sbjct: 1627 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-RLQAEEA 1685
Query: 216 ------------QMTCTDINTLTRQKELLLQ-KLSTFEETNRTLRDLLREQH-----CKE 257
+ + T R E LQ K ++F E L L+E+H +E
Sbjct: 1686 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1745
Query: 258 DSERLMEQQGALLKRLAEADSEKARLLLLLQDKDK---EVEELLQEIQCEKAQAKTASEL 314
++ER +QQ + EA+ E R L + + + EE+ Q+ +A+A+ E
Sbjct: 1746 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1805
Query: 315 SKSMESMRGHLQAQ-LRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDR 373
++ RG + Q +R +E L Q + L Q + E + +L+ ++G++
Sbjct: 1806 AEREARRRGKAEEQAVRQRELAEQELEKQ-RQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1864
Query: 374 DKESLKKAI-RAQKERAEKSEEYAE----------QLHVQLADKDLYVAEALSTLESWRS 422
++ L++ + R Q+E A +++ E ++ V LA K E+ ST E +
Sbjct: 1865 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1924
Query: 423 RYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKL 482
R +L E L + Q+Q EE R R AE A
Sbjct: 1925 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR----AEAERVLAEKLAAIG 1980
Query: 483 ENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLER 542
E RLK E L + E ++L+ ++ + Q + + + +E AQL +
Sbjct: 1981 EATRLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 2037
Query: 543 C-----DKENKILKD------EMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQD 591
+++ +++D ++ +EI A + F+ A +L L++ + + +D
Sbjct: 2038 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE--LELGRIR-SNAED 2094
Query: 592 QLQGYERKNIDLT-----AIISDLRSRIEHQGDKLEMAREKHQASQK-----ENKQLSLK 641
L+ E+ ++ A + R R + + +A E+ A Q+ E ++L K
Sbjct: 2095 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2154
Query: 642 VDE---LERKLEATSAQNIEFLQVIAKR----EE-----AIHQSQLRLEEKTRECGTLAR 689
V+E L + E SA+ ++ Q A++ EE A+ Q + L++ ++ ++
Sbjct: 2155 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2214
Query: 690 QLESAIEDARRQVEQTKEHALSKERAAQNKILDLE--TQLSRTKTELSQLR--------R 739
QL E ARR E+ +E + ER A +E +L ++ E +Q R +
Sbjct: 2215 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2274
Query: 740 SRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSS 779
R +A++ R Q + L Q ++ + M+ + +F + +
Sbjct: 2275 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2314
Score = 84.0 bits (206), Expect = 5e-16
Identities = 149/764 (19%), Positives = 310/764 (40%), Gaps = 126/764 (16%)
Query: 109 AVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKE---- 164
A L+SE+++ G+ + + E+L+ ++ + T+ VLR + E++KE
Sbjct: 1196 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1255
Query: 165 -------EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAA------------KQVMALK 205
E L+K Q E + + E+ GA +V +
Sbjct: 1256 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1315
Query: 206 DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQ 265
+ + +L Q + R+ E L ++L + E+ L L +D+ R EQ
Sbjct: 1316 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL------QDARRRQEQ 1369
Query: 266 QGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHL 325
++ + ADS+ R ++ ++ + LL+EI+ + + +K +
Sbjct: 1370 ----IQAMPLADSQAVR------EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1419
Query: 326 QAQLRSKEAENSRLCMQIKNLE-RSGNQ-----------HKAEVEAIMEQLKELKQKGDR 373
+ QL + +A+ + K + +SG++ H +E+ + Q + + R
Sbjct: 1420 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1479
Query: 374 DKESLKKAIRAQKERAEKSEEYAEQLHVQLA-DKDLYVAEALSTLESWRSRYNQVVKEKG 432
E ++ A+++RAE+ E AE V+ A +K +AEA + ++ R + ++++
Sbjct: 1480 RMEEEERL--AEQQRAEERERLAE---VEAALEKQRQLAEAHAQAKAQAEREAKELQQR- 1533
Query: 433 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERL-----HRQTAEYSAFKLENE-- 485
++ E++ + D Q+++++E++++ R S + + AE S ++E E
Sbjct: 1534 -MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1592
Query: 486 RLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLE------------- 532
++ E + A E+Q L+A + E + + + R +
Sbjct: 1593 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1652
Query: 533 --ADEVAAQLERCDKENKILK--DEMNKEIEAARRQF-QSQLADLQQLPDILKITEAKL- 586
A V A+ E ++ + L+ +E+ + E A R+ Q+++ +Q+ L+ +
Sbjct: 1653 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712
Query: 587 AECQDQLQGYERKNIDLT-------AIISDLRSRIEHQGDKLEMAREKHQASQKENKQLS 639
AE Q + + K L ++ LR E + + A + +++E ++
Sbjct: 1713 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1772
Query: 640 LKVDE-LERKLEATS-AQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQL-ESAIE 696
LK +E L +L+A AQ Q A++++ + + R K E R+L E +E
Sbjct: 1773 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1832
Query: 697 DARRQVEQTKEHALSKER-------------------------------AAQNKILDLET 725
R+ E T + L+ E+ AA K +LE
Sbjct: 1833 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1892
Query: 726 QLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSM 769
+L++ + E+ L S+ A+ +S + K RLE R +
Sbjct: 1893 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1936
Score = 65.1 bits (157), Expect = 3e-10
Identities = 100/504 (19%), Positives = 204/504 (40%), Gaps = 107/504 (21%)
Query: 113 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEH----ENTVLRHNIERMKEEKDF 168
LK + Q R A+ E+ ++E E+ A A+ E + +E+ K+ +
Sbjct: 2254 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2313
Query: 169 TILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQ 228
T+ QK ++QE L +L E + +++ LK + ++ ++ ++ Q
Sbjct: 2314 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2373
Query: 229 KELLLQKLSTFEETNRTLRDLLREQH-----CKEDSERLME------------QQGALLK 271
E L + + E NR L +LR++ +E++E++ + Q+ A L+
Sbjct: 2374 MEELSKLKARIEAENRAL--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2431
Query: 272 RLAEADSEKARLLL--LLQDKDKEVEE---LLQEIQCEKAQAKTASELSKSMESMRGHLQ 326
+LAE D + R L +L++K + V+E L E + + Q + A E ++ ++ + +
Sbjct: 2432 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2491
Query: 327 AQL--------RSKEAENSRLC--------MQIKNLERSGNQHKAEVEA----------- 359
QL R+ EAE R ++++ E S Q +AE +A
Sbjct: 2492 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2551
Query: 360 ---------------IMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHV--- 401
+++ L+ +Q+ D D E L++AI + EK ++ A+ L +
Sbjct: 2552 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2611
Query: 402 --QLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTL---- 455
Q ++ + E + +S+ S + +++ + +E E L D V + Q L
Sbjct: 2612 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2671
Query: 456 ----------------------------EEKMREDRDSLVERLHRQTAEYSAFKLENERL 487
EE +R ++ L + ++ + EN+RL
Sbjct: 2672 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2731
Query: 488 KASFAPMEDKLNQAHLEVQQLKAS 511
+ +E++ A +++ AS
Sbjct: 2732 REQLQLLEEQHRAALAHSEEVTAS 2755
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 119 bits (297), Expect = 1e-26
Identities = 160/728 (21%), Positives = 316/728 (43%), Gaps = 102/728 (14%)
Query: 124 RQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECL 183
R+ + LE +K +E+ + + E E L+ + E+ K L+ ++ E
Sbjct: 1877 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1936
Query: 184 MSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETN 243
+ +AE++ AA ++ +A ++ + + E+++ +L ++E Q+ + EE
Sbjct: 1937 LRSKEQAELE--AARQRQLAAEEERRRREAEERVQ----KSLAAEEEAARQRKAALEEVE 1990
Query: 244 RTLRDL-----LREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELL 298
R + LRE+ +E + +L Q A KRL + A +Q K++E+++ L
Sbjct: 1991 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA---FAVQQKEQELQQTL 2047
Query: 299 QEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGN---QHKA 355
Q+ Q Q + +E ++ + Q + A++ R + + L++S Q +A
Sbjct: 2048 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2107
Query: 356 EVEAIMEQL-KELKQKGDRDKESLKKAIRAQKERA----EKSEEYAEQLHVQLADKDLYV 410
+ +A E+L KE +Q+ R ++ + A+R QK+ A EK +++AEQ Q A V
Sbjct: 2108 QAQAAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEMEKHKKFAEQTLRQKAQ----V 2162
Query: 411 AEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKM---REDRDSLV 467
+ L+TL R + + +K L+ E+ L T+ Q+ +EE++ R + L
Sbjct: 2163 EQELTTL---RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2219
Query: 468 ERLHRQTAEYSAFKLENERLKASFAPME-DKLNQAHLEVQQLKASVKN------------ 514
+ R AE A L ++ F E +K+ Q E +L + +
Sbjct: 2220 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2279
Query: 515 --YEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADL 572
+ + + M+ EA + A+ E ++ K L E + ++ + Q QLA+
Sbjct: 2280 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ-KELAQEQARRLQEDKEQMAQQLAEE 2338
Query: 573 QQ------------------LPDILKITEAKLAECQ------------------DQLQGY 596
Q + LK+ A+++ Q ++L
Sbjct: 2339 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2398
Query: 597 E---RKNIDLTAIISDLRSRIEHQGDKL-----EMAREKHQASQKENKQLSLKVDEL--- 645
E ++ + L + R + +H ++L E+ REK + Q+E K L LK +E+
Sbjct: 2399 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL-QQEAKLLQLKSEEMQTV 2457
Query: 646 --ERKLEATSAQNIEFLQV---IAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARR 700
E+ L+ T A FL + +RE I Q + +LE+ ++ A+QL + ++
Sbjct: 2458 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2517
Query: 701 QVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLE 760
Q+EQ ++ ++ A+ + + E + R + EL QL + R + Q L+++L+
Sbjct: 2518 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2577
Query: 761 QSESTNRS 768
E +R+
Sbjct: 2578 LLEEQHRA 2585
Score = 107 bits (268), Expect = 3e-23
Identities = 157/692 (22%), Positives = 303/692 (43%), Gaps = 80/692 (11%)
Query: 119 MQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQ 178
M + Q + L + + LEE+ + E + I +K+ + + K L+
Sbjct: 1214 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1273
Query: 179 EKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQK-ELLLQKLS 237
+ A +V + +++ + + + +++ TLT Q + + + L
Sbjct: 1274 -------------VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1320
Query: 238 TFEETNRTLRDLLREQHCKEDSERLMEQQGALLKR--LAEADSEKARLLLLLQDKDKEVE 295
EE R L EQ E+ ERL E + AL K+ LAEA ++ ++E +
Sbjct: 1321 RMEEEER-----LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA------QAEREAK 1369
Query: 296 ELLQEIQCEKAQAKTAS-ELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHK 354
EL Q +Q E + + A+ + + S++ LQ +S EAE Q + ERS + +
Sbjct: 1370 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1429
Query: 355 AEVEAIMEQLKEL-KQKGDRDKESLKKAIRAQKERAE----KSEEYAEQLHVQLADKDLY 409
E+ + QL+ +Q+G + E +A+RA+ E AE +++E AE+L Q+ D+
Sbjct: 1430 EEIRVVRLQLEATERQRGGAEGEL--QALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1487
Query: 410 VAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVER 469
+A L S + +EK + L + EE R R + VER
Sbjct: 1488 KRQAEVELASRVKAEAEAAREK----------QRALQALEELRLQAEEAERRLRQAEVER 1537
Query: 470 LHR-----QTAEYSAFKLENERLKASFAP----MEDKLNQAHLEVQQLKASVKNY----- 515
+ +TA+ SA + E + +ASFA +E L + H+ V QL+ +
Sbjct: 1538 ARQVQVALETAQRSA-EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1596
Query: 516 --EGMIDNYKSQVMKTRLEADE---VAAQLERCDKENKILKDEMNKEIEAARRQFQSQLA 570
E + + ++ + +L+A+E + Q E ++ + + E K+ E A R+ + +
Sbjct: 1597 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1656
Query: 571 DLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQA 630
+Q ++ E +L + + +G ++ + + LR+ E + ++ E+
Sbjct: 1657 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1716
Query: 631 SQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREE----AIHQSQLRLEEKT---RE 683
Q+E + K ELE +L A+ L A+ EE +S+ RLE + RE
Sbjct: 1717 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1776
Query: 684 CGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLET----QLSRTKTELSQLRR 739
A +L + E+A+RQ + +E A +++RA ++L + + +R KTE +
Sbjct: 1777 LAEEAARLRALAEEAKRQRQLAEEDA-ARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1835
Query: 740 SRDDADRRYQSRLQD---LKDRLEQSESTNRS 768
++ + R + +D + RLE+ + +++
Sbjct: 1836 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1867
Score = 104 bits (260), Expect = 3e-22
Identities = 159/760 (20%), Positives = 317/760 (41%), Gaps = 106/760 (13%)
Query: 114 KSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQK 173
++E++ + + + A+R +EE+ V +L TE + ++ ++ + QK
Sbjct: 1408 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1467
Query: 174 KHLQQEKECL-----------------MSKLVEAEMDGAAAAKQVMALKDTIGKLKTEK- 215
+ Q+E E L ++ V+AE + A ++ + + + +L+ E+
Sbjct: 1468 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-RLQAEEA 1526
Query: 216 ------------QMTCTDINTLTRQKELLLQ-KLSTFEETNRTLRDLLREQH-----CKE 257
+ + T R E LQ K ++F E L L+E+H +E
Sbjct: 1527 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1586
Query: 258 DSERLMEQQGALLKRLAEADSEKARLLLLLQDKDK---EVEELLQEIQCEKAQAKTASEL 314
++ER +QQ + EA+ E R L + + + EE+ Q+ +A+A+ E
Sbjct: 1587 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1646
Query: 315 SKSMESMRGHLQAQ-LRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDR 373
++ RG + Q +R +E L Q + L Q + E + +L+ ++G++
Sbjct: 1647 AEREARRRGKAEEQAVRQRELAEQELEKQ-RQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1705
Query: 374 DKESLKKAI-RAQKERAEKSEEYAE----------QLHVQLADKDLYVAEALSTLESWRS 422
++ L++ + R Q+E A +++ E ++ V LA K E+ ST E +
Sbjct: 1706 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1765
Query: 423 RYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKL 482
R +L E L + Q+Q EE R R AE A
Sbjct: 1766 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR----AEAERVLAEKLAAIG 1821
Query: 483 ENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLER 542
E RLK E L + E ++L+ ++ + Q + + + +E AQL +
Sbjct: 1822 EATRLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1878
Query: 543 C-----DKENKILKD------EMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQD 591
+++ +++D ++ +EI A + F+ A +L L++ + + +D
Sbjct: 1879 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE--LELGRIR-SNAED 1935
Query: 592 QLQGYERKNIDLT-----AIISDLRSRIEHQGDKLEMAREKHQASQK-----ENKQLSLK 641
L+ E+ ++ A + R R + + +A E+ A Q+ E ++L K
Sbjct: 1936 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1995
Query: 642 VDE---LERKLEATSAQNIEFLQVIAKR----EE-----AIHQSQLRLEEKTRECGTLAR 689
V+E L + E SA+ ++ Q A++ EE A+ Q + L++ ++ ++
Sbjct: 1996 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2055
Query: 690 QLESAIEDARRQVEQTKEHALSKERAAQNKILDLE--TQLSRTKTELSQLR--------R 739
QL E ARR E+ +E + ER A +E +L ++ E +Q R +
Sbjct: 2056 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2115
Query: 740 SRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSS 779
R +A++ R Q + L Q ++ + M+ + +F + +
Sbjct: 2116 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2155
Score = 84.0 bits (206), Expect = 5e-16
Identities = 149/764 (19%), Positives = 310/764 (40%), Gaps = 126/764 (16%)
Query: 109 AVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKE---- 164
A L+SE+++ G+ + + E+L+ ++ + T+ VLR + E++KE
Sbjct: 1037 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1096
Query: 165 -------EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAA------------KQVMALK 205
E L+K Q E + + E+ GA +V +
Sbjct: 1097 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1156
Query: 206 DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQ 265
+ + +L Q + R+ E L ++L + E+ L L +D+ R EQ
Sbjct: 1157 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL------QDARRRQEQ 1210
Query: 266 QGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHL 325
++ + ADS+ R ++ ++ + LL+EI+ + + +K +
Sbjct: 1211 ----IQAMPLADSQAVR------EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1260
Query: 326 QAQLRSKEAENSRLCMQIKNLE-RSGNQ-----------HKAEVEAIMEQLKELKQKGDR 373
+ QL + +A+ + K + +SG++ H +E+ + Q + + R
Sbjct: 1261 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1320
Query: 374 DKESLKKAIRAQKERAEKSEEYAEQLHVQLA-DKDLYVAEALSTLESWRSRYNQVVKEKG 432
E ++ A+++RAE+ E AE V+ A +K +AEA + ++ R + ++++
Sbjct: 1321 RMEEEERL--AEQQRAEERERLAE---VEAALEKQRQLAEAHAQAKAQAEREAKELQQR- 1374
Query: 433 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERL-----HRQTAEYSAFKLENE-- 485
++ E++ + D Q+++++E++++ R S + + AE S ++E E
Sbjct: 1375 -MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1433
Query: 486 RLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLE------------- 532
++ E + A E+Q L+A + E + + + R +
Sbjct: 1434 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1493
Query: 533 --ADEVAAQLERCDKENKILK--DEMNKEIEAARRQF-QSQLADLQQLPDILKITEAKL- 586
A V A+ E ++ + L+ +E+ + E A R+ Q+++ +Q+ L+ +
Sbjct: 1494 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553
Query: 587 AECQDQLQGYERKNIDLT-------AIISDLRSRIEHQGDKLEMAREKHQASQKENKQLS 639
AE Q + + K L ++ LR E + + A + +++E ++
Sbjct: 1554 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1613
Query: 640 LKVDE-LERKLEATS-AQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQL-ESAIE 696
LK +E L +L+A AQ Q A++++ + + R K E R+L E +E
Sbjct: 1614 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1673
Query: 697 DARRQVEQTKEHALSKER-------------------------------AAQNKILDLET 725
R+ E T + L+ E+ AA K +LE
Sbjct: 1674 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1733
Query: 726 QLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSM 769
+L++ + E+ L S+ A+ +S + K RLE R +
Sbjct: 1734 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1777
Score = 65.1 bits (157), Expect = 3e-10
Identities = 100/504 (19%), Positives = 204/504 (40%), Gaps = 107/504 (21%)
Query: 113 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEH----ENTVLRHNIERMKEEKDF 168
LK + Q R A+ E+ ++E E+ A A+ E + +E+ K+ +
Sbjct: 2095 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2154
Query: 169 TILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQ 228
T+ QK ++QE L +L E + +++ LK + ++ ++ ++ Q
Sbjct: 2155 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2214
Query: 229 KELLLQKLSTFEETNRTLRDLLREQH-----CKEDSERLME------------QQGALLK 271
E L + + E NR L +LR++ +E++E++ + Q+ A L+
Sbjct: 2215 MEELSKLKARIEAENRAL--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2272
Query: 272 RLAEADSEKARLLL--LLQDKDKEVEE---LLQEIQCEKAQAKTASELSKSMESMRGHLQ 326
+LAE D + R L +L++K + V+E L E + + Q + A E ++ ++ + +
Sbjct: 2273 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2332
Query: 327 AQL--------RSKEAENSRLC--------MQIKNLERSGNQHKAEVEA----------- 359
QL R+ EAE R ++++ E S Q +AE +A
Sbjct: 2333 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2392
Query: 360 ---------------IMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHV--- 401
+++ L+ +Q+ D D E L++AI + EK ++ A+ L +
Sbjct: 2393 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2452
Query: 402 --QLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTL---- 455
Q ++ + E + +S+ S + +++ + +E E L D V + Q L
Sbjct: 2453 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2512
Query: 456 ----------------------------EEKMREDRDSLVERLHRQTAEYSAFKLENERL 487
EE +R ++ L + ++ + EN+RL
Sbjct: 2513 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2572
Query: 488 KASFAPMEDKLNQAHLEVQQLKAS 511
+ +E++ A +++ AS
Sbjct: 2573 REQLQLLEEQHRAALAHSEEVTAS 2596
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 119 bits (297), Expect = 1e-26
Identities = 160/728 (21%), Positives = 316/728 (43%), Gaps = 102/728 (14%)
Query: 124 RQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECL 183
R+ + LE +K +E+ + + E E L+ + E+ K L+ ++ E
Sbjct: 1885 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1944
Query: 184 MSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETN 243
+ +AE++ AA ++ +A ++ + + E+++ +L ++E Q+ + EE
Sbjct: 1945 LRSKEQAELE--AARQRQLAAEEERRRREAEERVQ----KSLAAEEEAARQRKAALEEVE 1998
Query: 244 RTLRDL-----LREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELL 298
R + LRE+ +E + +L Q A KRL + A +Q K++E+++ L
Sbjct: 1999 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA---FAVQQKEQELQQTL 2055
Query: 299 QEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGN---QHKA 355
Q+ Q Q + +E ++ + Q + A++ R + + L++S Q +A
Sbjct: 2056 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2115
Query: 356 EVEAIMEQL-KELKQKGDRDKESLKKAIRAQKERA----EKSEEYAEQLHVQLADKDLYV 410
+ +A E+L KE +Q+ R ++ + A+R QK+ A EK +++AEQ Q A V
Sbjct: 2116 QAQAAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEMEKHKKFAEQTLRQKAQ----V 2170
Query: 411 AEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKM---REDRDSLV 467
+ L+TL R + + +K L+ E+ L T+ Q+ +EE++ R + L
Sbjct: 2171 EQELTTL---RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2227
Query: 468 ERLHRQTAEYSAFKLENERLKASFAPME-DKLNQAHLEVQQLKASVKN------------ 514
+ R AE A L ++ F E +K+ Q E +L + +
Sbjct: 2228 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2287
Query: 515 --YEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADL 572
+ + + M+ EA + A+ E ++ K L E + ++ + Q QLA+
Sbjct: 2288 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ-KELAQEQARRLQEDKEQMAQQLAEE 2346
Query: 573 QQ------------------LPDILKITEAKLAECQ------------------DQLQGY 596
Q + LK+ A+++ Q ++L
Sbjct: 2347 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2406
Query: 597 E---RKNIDLTAIISDLRSRIEHQGDKL-----EMAREKHQASQKENKQLSLKVDEL--- 645
E ++ + L + R + +H ++L E+ REK + Q+E K L LK +E+
Sbjct: 2407 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL-QQEAKLLQLKSEEMQTV 2465
Query: 646 --ERKLEATSAQNIEFLQV---IAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARR 700
E+ L+ T A FL + +RE I Q + +LE+ ++ A+QL + ++
Sbjct: 2466 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2525
Query: 701 QVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLE 760
Q+EQ ++ ++ A+ + + E + R + EL QL + R + Q L+++L+
Sbjct: 2526 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2585
Query: 761 QSESTNRS 768
E +R+
Sbjct: 2586 LLEEQHRA 2593
Score = 107 bits (268), Expect = 3e-23
Identities = 157/692 (22%), Positives = 303/692 (43%), Gaps = 80/692 (11%)
Query: 119 MQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQ 178
M + Q + L + + LEE+ + E + I +K+ + + K L+
Sbjct: 1222 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1281
Query: 179 EKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQK-ELLLQKLS 237
+ A +V + +++ + + + +++ TLT Q + + + L
Sbjct: 1282 -------------VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1328
Query: 238 TFEETNRTLRDLLREQHCKEDSERLMEQQGALLKR--LAEADSEKARLLLLLQDKDKEVE 295
EE R L EQ E+ ERL E + AL K+ LAEA ++ ++E +
Sbjct: 1329 RMEEEER-----LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA------QAEREAK 1377
Query: 296 ELLQEIQCEKAQAKTAS-ELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHK 354
EL Q +Q E + + A+ + + S++ LQ +S EAE Q + ERS + +
Sbjct: 1378 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1437
Query: 355 AEVEAIMEQLKEL-KQKGDRDKESLKKAIRAQKERAE----KSEEYAEQLHVQLADKDLY 409
E+ + QL+ +Q+G + E +A+RA+ E AE +++E AE+L Q+ D+
Sbjct: 1438 EEIRVVRLQLEATERQRGGAEGEL--QALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1495
Query: 410 VAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVER 469
+A L S + +EK + L + EE R R + VER
Sbjct: 1496 KRQAEVELASRVKAEAEAAREK----------QRALQALEELRLQAEEAERRLRQAEVER 1545
Query: 470 LHR-----QTAEYSAFKLENERLKASFAP----MEDKLNQAHLEVQQLKASVKNY----- 515
+ +TA+ SA + E + +ASFA +E L + H+ V QL+ +
Sbjct: 1546 ARQVQVALETAQRSA-EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1604
Query: 516 --EGMIDNYKSQVMKTRLEADE---VAAQLERCDKENKILKDEMNKEIEAARRQFQSQLA 570
E + + ++ + +L+A+E + Q E ++ + + E K+ E A R+ + +
Sbjct: 1605 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1664
Query: 571 DLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQA 630
+Q ++ E +L + + +G ++ + + LR+ E + ++ E+
Sbjct: 1665 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1724
Query: 631 SQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREE----AIHQSQLRLEEKT---RE 683
Q+E + K ELE +L A+ L A+ EE +S+ RLE + RE
Sbjct: 1725 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1784
Query: 684 CGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLET----QLSRTKTELSQLRR 739
A +L + E+A+RQ + +E A +++RA ++L + + +R KTE +
Sbjct: 1785 LAEEAARLRALAEEAKRQRQLAEEDA-ARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1843
Query: 740 SRDDADRRYQSRLQD---LKDRLEQSESTNRS 768
++ + R + +D + RLE+ + +++
Sbjct: 1844 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1875
Score = 104 bits (260), Expect = 3e-22
Identities = 159/760 (20%), Positives = 317/760 (41%), Gaps = 106/760 (13%)
Query: 114 KSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQK 173
++E++ + + + A+R +EE+ V +L TE + ++ ++ + QK
Sbjct: 1416 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1475
Query: 174 KHLQQEKECL-----------------MSKLVEAEMDGAAAAKQVMALKDTIGKLKTEK- 215
+ Q+E E L ++ V+AE + A ++ + + + +L+ E+
Sbjct: 1476 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-RLQAEEA 1534
Query: 216 ------------QMTCTDINTLTRQKELLLQ-KLSTFEETNRTLRDLLREQH-----CKE 257
+ + T R E LQ K ++F E L L+E+H +E
Sbjct: 1535 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1594
Query: 258 DSERLMEQQGALLKRLAEADSEKARLLLLLQDKDK---EVEELLQEIQCEKAQAKTASEL 314
++ER +QQ + EA+ E R L + + + EE+ Q+ +A+A+ E
Sbjct: 1595 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1654
Query: 315 SKSMESMRGHLQAQ-LRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDR 373
++ RG + Q +R +E L Q + L Q + E + +L+ ++G++
Sbjct: 1655 AEREARRRGKAEEQAVRQRELAEQELEKQ-RQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1713
Query: 374 DKESLKKAI-RAQKERAEKSEEYAE----------QLHVQLADKDLYVAEALSTLESWRS 422
++ L++ + R Q+E A +++ E ++ V LA K E+ ST E +
Sbjct: 1714 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1773
Query: 423 RYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKL 482
R +L E L + Q+Q EE R R AE A
Sbjct: 1774 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR----AEAERVLAEKLAAIG 1829
Query: 483 ENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLER 542
E RLK E L + E ++L+ ++ + Q + + + +E AQL +
Sbjct: 1830 EATRLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1886
Query: 543 C-----DKENKILKD------EMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQD 591
+++ +++D ++ +EI A + F+ A +L L++ + + +D
Sbjct: 1887 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE--LELGRIR-SNAED 1943
Query: 592 QLQGYERKNIDLT-----AIISDLRSRIEHQGDKLEMAREKHQASQK-----ENKQLSLK 641
L+ E+ ++ A + R R + + +A E+ A Q+ E ++L K
Sbjct: 1944 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2003
Query: 642 VDE---LERKLEATSAQNIEFLQVIAKR----EE-----AIHQSQLRLEEKTRECGTLAR 689
V+E L + E SA+ ++ Q A++ EE A+ Q + L++ ++ ++
Sbjct: 2004 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2063
Query: 690 QLESAIEDARRQVEQTKEHALSKERAAQNKILDLE--TQLSRTKTELSQLR--------R 739
QL E ARR E+ +E + ER A +E +L ++ E +Q R +
Sbjct: 2064 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2123
Query: 740 SRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSS 779
R +A++ R Q + L Q ++ + M+ + +F + +
Sbjct: 2124 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2163
Score = 84.0 bits (206), Expect = 5e-16
Identities = 149/764 (19%), Positives = 310/764 (40%), Gaps = 126/764 (16%)
Query: 109 AVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKE---- 164
A L+SE+++ G+ + + E+L+ ++ + T+ VLR + E++KE
Sbjct: 1045 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1104
Query: 165 -------EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAA------------KQVMALK 205
E L+K Q E + + E+ GA +V +
Sbjct: 1105 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1164
Query: 206 DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQ 265
+ + +L Q + R+ E L ++L + E+ L L +D+ R EQ
Sbjct: 1165 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL------QDARRRQEQ 1218
Query: 266 QGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHL 325
++ + ADS+ R ++ ++ + LL+EI+ + + +K +
Sbjct: 1219 ----IQAMPLADSQAVR------EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1268
Query: 326 QAQLRSKEAENSRLCMQIKNLE-RSGNQ-----------HKAEVEAIMEQLKELKQKGDR 373
+ QL + +A+ + K + +SG++ H +E+ + Q + + R
Sbjct: 1269 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1328
Query: 374 DKESLKKAIRAQKERAEKSEEYAEQLHVQLA-DKDLYVAEALSTLESWRSRYNQVVKEKG 432
E ++ A+++RAE+ E AE V+ A +K +AEA + ++ R + ++++
Sbjct: 1329 RMEEEERL--AEQQRAEERERLAE---VEAALEKQRQLAEAHAQAKAQAEREAKELQQR- 1382
Query: 433 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERL-----HRQTAEYSAFKLENE-- 485
++ E++ + D Q+++++E++++ R S + + AE S ++E E
Sbjct: 1383 -MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1441
Query: 486 RLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLE------------- 532
++ E + A E+Q L+A + E + + + R +
Sbjct: 1442 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1501
Query: 533 --ADEVAAQLERCDKENKILK--DEMNKEIEAARRQF-QSQLADLQQLPDILKITEAKL- 586
A V A+ E ++ + L+ +E+ + E A R+ Q+++ +Q+ L+ +
Sbjct: 1502 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1561
Query: 587 AECQDQLQGYERKNIDLT-------AIISDLRSRIEHQGDKLEMAREKHQASQKENKQLS 639
AE Q + + K L ++ LR E + + A + +++E ++
Sbjct: 1562 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1621
Query: 640 LKVDE-LERKLEATS-AQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQL-ESAIE 696
LK +E L +L+A AQ Q A++++ + + R K E R+L E +E
Sbjct: 1622 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1681
Query: 697 DARRQVEQTKEHALSKER-------------------------------AAQNKILDLET 725
R+ E T + L+ E+ AA K +LE
Sbjct: 1682 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1741
Query: 726 QLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSM 769
+L++ + E+ L S+ A+ +S + K RLE R +
Sbjct: 1742 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1785
Score = 65.1 bits (157), Expect = 3e-10
Identities = 100/504 (19%), Positives = 204/504 (40%), Gaps = 107/504 (21%)
Query: 113 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEH----ENTVLRHNIERMKEEKDF 168
LK + Q R A+ E+ ++E E+ A A+ E + +E+ K+ +
Sbjct: 2103 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2162
Query: 169 TILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQ 228
T+ QK ++QE L +L E + +++ LK + ++ ++ ++ Q
Sbjct: 2163 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2222
Query: 229 KELLLQKLSTFEETNRTLRDLLREQH-----CKEDSERLME------------QQGALLK 271
E L + + E NR L +LR++ +E++E++ + Q+ A L+
Sbjct: 2223 MEELSKLKARIEAENRAL--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2280
Query: 272 RLAEADSEKARLLL--LLQDKDKEVEE---LLQEIQCEKAQAKTASELSKSMESMRGHLQ 326
+LAE D + R L +L++K + V+E L E + + Q + A E ++ ++ + +
Sbjct: 2281 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2340
Query: 327 AQL--------RSKEAENSRLC--------MQIKNLERSGNQHKAEVEA----------- 359
QL R+ EAE R ++++ E S Q +AE +A
Sbjct: 2341 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2400
Query: 360 ---------------IMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHV--- 401
+++ L+ +Q+ D D E L++AI + EK ++ A+ L +
Sbjct: 2401 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2460
Query: 402 --QLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTL---- 455
Q ++ + E + +S+ S + +++ + +E E L D V + Q L
Sbjct: 2461 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2520
Query: 456 ----------------------------EEKMREDRDSLVERLHRQTAEYSAFKLENERL 487
EE +R ++ L + ++ + EN+RL
Sbjct: 2521 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2580
Query: 488 KASFAPMEDKLNQAHLEVQQLKAS 511
+ +E++ A +++ AS
Sbjct: 2581 REQLQLLEEQHRAALAHSEEVTAS 2604
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 119 bits (297), Expect = 1e-26
Identities = 160/728 (21%), Positives = 316/728 (43%), Gaps = 102/728 (14%)
Query: 124 RQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECL 183
R+ + LE +K +E+ + + E E L+ + E+ K L+ ++ E
Sbjct: 1926 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1985
Query: 184 MSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETN 243
+ +AE++ AA ++ +A ++ + + E+++ +L ++E Q+ + EE
Sbjct: 1986 LRSKEQAELE--AARQRQLAAEEERRRREAEERVQ----KSLAAEEEAARQRKAALEEVE 2039
Query: 244 RTLRDL-----LREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELL 298
R + LRE+ +E + +L Q A KRL + A +Q K++E+++ L
Sbjct: 2040 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA---FAVQQKEQELQQTL 2096
Query: 299 QEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGN---QHKA 355
Q+ Q Q + +E ++ + Q + A++ R + + L++S Q +A
Sbjct: 2097 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2156
Query: 356 EVEAIMEQL-KELKQKGDRDKESLKKAIRAQKERA----EKSEEYAEQLHVQLADKDLYV 410
+ +A E+L KE +Q+ R ++ + A+R QK+ A EK +++AEQ Q A V
Sbjct: 2157 QAQAAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEMEKHKKFAEQTLRQKAQ----V 2211
Query: 411 AEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKM---REDRDSLV 467
+ L+TL R + + +K L+ E+ L T+ Q+ +EE++ R + L
Sbjct: 2212 EQELTTL---RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2268
Query: 468 ERLHRQTAEYSAFKLENERLKASFAPME-DKLNQAHLEVQQLKASVKN------------ 514
+ R AE A L ++ F E +K+ Q E +L + +
Sbjct: 2269 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2328
Query: 515 --YEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADL 572
+ + + M+ EA + A+ E ++ K L E + ++ + Q QLA+
Sbjct: 2329 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ-KELAQEQARRLQEDKEQMAQQLAEE 2387
Query: 573 QQ------------------LPDILKITEAKLAECQ------------------DQLQGY 596
Q + LK+ A+++ Q ++L
Sbjct: 2388 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2447
Query: 597 E---RKNIDLTAIISDLRSRIEHQGDKL-----EMAREKHQASQKENKQLSLKVDEL--- 645
E ++ + L + R + +H ++L E+ REK + Q+E K L LK +E+
Sbjct: 2448 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL-QQEAKLLQLKSEEMQTV 2506
Query: 646 --ERKLEATSAQNIEFLQV---IAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARR 700
E+ L+ T A FL + +RE I Q + +LE+ ++ A+QL + ++
Sbjct: 2507 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2566
Query: 701 QVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLE 760
Q+EQ ++ ++ A+ + + E + R + EL QL + R + Q L+++L+
Sbjct: 2567 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2626
Query: 761 QSESTNRS 768
E +R+
Sbjct: 2627 LLEEQHRA 2634
Score = 107 bits (268), Expect = 3e-23
Identities = 157/692 (22%), Positives = 303/692 (43%), Gaps = 80/692 (11%)
Query: 119 MQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQ 178
M + Q + L + + LEE+ + E + I +K+ + + K L+
Sbjct: 1263 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1322
Query: 179 EKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQK-ELLLQKLS 237
+ A +V + +++ + + + +++ TLT Q + + + L
Sbjct: 1323 -------------VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1369
Query: 238 TFEETNRTLRDLLREQHCKEDSERLMEQQGALLKR--LAEADSEKARLLLLLQDKDKEVE 295
EE R L EQ E+ ERL E + AL K+ LAEA ++ ++E +
Sbjct: 1370 RMEEEER-----LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA------QAEREAK 1418
Query: 296 ELLQEIQCEKAQAKTAS-ELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHK 354
EL Q +Q E + + A+ + + S++ LQ +S EAE Q + ERS + +
Sbjct: 1419 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1478
Query: 355 AEVEAIMEQLKEL-KQKGDRDKESLKKAIRAQKERAE----KSEEYAEQLHVQLADKDLY 409
E+ + QL+ +Q+G + E +A+RA+ E AE +++E AE+L Q+ D+
Sbjct: 1479 EEIRVVRLQLEATERQRGGAEGEL--QALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1536
Query: 410 VAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVER 469
+A L S + +EK + L + EE R R + VER
Sbjct: 1537 KRQAEVELASRVKAEAEAAREK----------QRALQALEELRLQAEEAERRLRQAEVER 1586
Query: 470 LHR-----QTAEYSAFKLENERLKASFAP----MEDKLNQAHLEVQQLKASVKNY----- 515
+ +TA+ SA + E + +ASFA +E L + H+ V QL+ +
Sbjct: 1587 ARQVQVALETAQRSA-EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1645
Query: 516 --EGMIDNYKSQVMKTRLEADE---VAAQLERCDKENKILKDEMNKEIEAARRQFQSQLA 570
E + + ++ + +L+A+E + Q E ++ + + E K+ E A R+ + +
Sbjct: 1646 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1705
Query: 571 DLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQA 630
+Q ++ E +L + + +G ++ + + LR+ E + ++ E+
Sbjct: 1706 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1765
Query: 631 SQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREE----AIHQSQLRLEEKT---RE 683
Q+E + K ELE +L A+ L A+ EE +S+ RLE + RE
Sbjct: 1766 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1825
Query: 684 CGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLET----QLSRTKTELSQLRR 739
A +L + E+A+RQ + +E A +++RA ++L + + +R KTE +
Sbjct: 1826 LAEEAARLRALAEEAKRQRQLAEEDA-ARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1884
Query: 740 SRDDADRRYQSRLQD---LKDRLEQSESTNRS 768
++ + R + +D + RLE+ + +++
Sbjct: 1885 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1916
Score = 104 bits (260), Expect = 3e-22
Identities = 159/760 (20%), Positives = 317/760 (41%), Gaps = 106/760 (13%)
Query: 114 KSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQK 173
++E++ + + + A+R +EE+ V +L TE + ++ ++ + QK
Sbjct: 1457 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1516
Query: 174 KHLQQEKECL-----------------MSKLVEAEMDGAAAAKQVMALKDTIGKLKTEK- 215
+ Q+E E L ++ V+AE + A ++ + + + +L+ E+
Sbjct: 1517 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-RLQAEEA 1575
Query: 216 ------------QMTCTDINTLTRQKELLLQ-KLSTFEETNRTLRDLLREQH-----CKE 257
+ + T R E LQ K ++F E L L+E+H +E
Sbjct: 1576 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1635
Query: 258 DSERLMEQQGALLKRLAEADSEKARLLLLLQDKDK---EVEELLQEIQCEKAQAKTASEL 314
++ER +QQ + EA+ E R L + + + EE+ Q+ +A+A+ E
Sbjct: 1636 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1695
Query: 315 SKSMESMRGHLQAQ-LRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDR 373
++ RG + Q +R +E L Q + L Q + E + +L+ ++G++
Sbjct: 1696 AEREARRRGKAEEQAVRQRELAEQELEKQ-RQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1754
Query: 374 DKESLKKAI-RAQKERAEKSEEYAE----------QLHVQLADKDLYVAEALSTLESWRS 422
++ L++ + R Q+E A +++ E ++ V LA K E+ ST E +
Sbjct: 1755 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1814
Query: 423 RYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKL 482
R +L E L + Q+Q EE R R AE A
Sbjct: 1815 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR----AEAERVLAEKLAAIG 1870
Query: 483 ENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLER 542
E RLK E L + E ++L+ ++ + Q + + + +E AQL +
Sbjct: 1871 EATRLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1927
Query: 543 C-----DKENKILKD------EMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQD 591
+++ +++D ++ +EI A + F+ A +L L++ + + +D
Sbjct: 1928 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE--LELGRIR-SNAED 1984
Query: 592 QLQGYERKNIDLT-----AIISDLRSRIEHQGDKLEMAREKHQASQK-----ENKQLSLK 641
L+ E+ ++ A + R R + + +A E+ A Q+ E ++L K
Sbjct: 1985 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2044
Query: 642 VDE---LERKLEATSAQNIEFLQVIAKR----EE-----AIHQSQLRLEEKTRECGTLAR 689
V+E L + E SA+ ++ Q A++ EE A+ Q + L++ ++ ++
Sbjct: 2045 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2104
Query: 690 QLESAIEDARRQVEQTKEHALSKERAAQNKILDLE--TQLSRTKTELSQLR--------R 739
QL E ARR E+ +E + ER A +E +L ++ E +Q R +
Sbjct: 2105 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2164
Query: 740 SRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSS 779
R +A++ R Q + L Q ++ + M+ + +F + +
Sbjct: 2165 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2204
Score = 84.0 bits (206), Expect = 5e-16
Identities = 149/764 (19%), Positives = 310/764 (40%), Gaps = 126/764 (16%)
Query: 109 AVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKE---- 164
A L+SE+++ G+ + + E+L+ ++ + T+ VLR + E++KE
Sbjct: 1086 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1145
Query: 165 -------EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAA------------KQVMALK 205
E L+K Q E + + E+ GA +V +
Sbjct: 1146 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1205
Query: 206 DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQ 265
+ + +L Q + R+ E L ++L + E+ L L +D+ R EQ
Sbjct: 1206 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL------QDARRRQEQ 1259
Query: 266 QGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHL 325
++ + ADS+ R ++ ++ + LL+EI+ + + +K +
Sbjct: 1260 ----IQAMPLADSQAVR------EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1309
Query: 326 QAQLRSKEAENSRLCMQIKNLE-RSGNQ-----------HKAEVEAIMEQLKELKQKGDR 373
+ QL + +A+ + K + +SG++ H +E+ + Q + + R
Sbjct: 1310 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1369
Query: 374 DKESLKKAIRAQKERAEKSEEYAEQLHVQLA-DKDLYVAEALSTLESWRSRYNQVVKEKG 432
E ++ A+++RAE+ E AE V+ A +K +AEA + ++ R + ++++
Sbjct: 1370 RMEEEERL--AEQQRAEERERLAE---VEAALEKQRQLAEAHAQAKAQAEREAKELQQR- 1423
Query: 433 DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERL-----HRQTAEYSAFKLENE-- 485
++ E++ + D Q+++++E++++ R S + + AE S ++E E
Sbjct: 1424 -MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1482
Query: 486 RLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLE------------- 532
++ E + A E+Q L+A + E + + + R +
Sbjct: 1483 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1542
Query: 533 --ADEVAAQLERCDKENKILK--DEMNKEIEAARRQF-QSQLADLQQLPDILKITEAKL- 586
A V A+ E ++ + L+ +E+ + E A R+ Q+++ +Q+ L+ +
Sbjct: 1543 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1602
Query: 587 AECQDQLQGYERKNIDLT-------AIISDLRSRIEHQGDKLEMAREKHQASQKENKQLS 639
AE Q + + K L ++ LR E + + A + +++E ++
Sbjct: 1603 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1662
Query: 640 LKVDE-LERKLEATS-AQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQL-ESAIE 696
LK +E L +L+A AQ Q A++++ + + R K E R+L E +E
Sbjct: 1663 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1722
Query: 697 DARRQVEQTKEHALSKER-------------------------------AAQNKILDLET 725
R+ E T + L+ E+ AA K +LE
Sbjct: 1723 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1782
Query: 726 QLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSM 769
+L++ + E+ L S+ A+ +S + K RLE R +
Sbjct: 1783 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1826
Score = 65.1 bits (157), Expect = 3e-10
Identities = 100/504 (19%), Positives = 204/504 (40%), Gaps = 107/504 (21%)
Query: 113 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEH----ENTVLRHNIERMKEEKDF 168
LK + Q R A+ E+ ++E E+ A A+ E + +E+ K+ +
Sbjct: 2144 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2203
Query: 169 TILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQ 228
T+ QK ++QE L +L E + +++ LK + ++ ++ ++ Q
Sbjct: 2204 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2263
Query: 229 KELLLQKLSTFEETNRTLRDLLREQH-----CKEDSERLME------------QQGALLK 271
E L + + E NR L +LR++ +E++E++ + Q+ A L+
Sbjct: 2264 MEELSKLKARIEAENRAL--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2321
Query: 272 RLAEADSEKARLLL--LLQDKDKEVEE---LLQEIQCEKAQAKTASELSKSMESMRGHLQ 326
+LAE D + R L +L++K + V+E L E + + Q + A E ++ ++ + +
Sbjct: 2322 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2381
Query: 327 AQL--------RSKEAENSRLC--------MQIKNLERSGNQHKAEVEA----------- 359
QL R+ EAE R ++++ E S Q +AE +A
Sbjct: 2382 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2441
Query: 360 ---------------IMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHV--- 401
+++ L+ +Q+ D D E L++AI + EK ++ A+ L +
Sbjct: 2442 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2501
Query: 402 --QLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTL---- 455
Q ++ + E + +S+ S + +++ + +E E L D V + Q L
Sbjct: 2502 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2561
Query: 456 ----------------------------EEKMREDRDSLVERLHRQTAEYSAFKLENERL 487
EE +R ++ L + ++ + EN+RL
Sbjct: 2562 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2621
Query: 488 KASFAPMEDKLNQAHLEVQQLKAS 511
+ +E++ A +++ AS
Sbjct: 2622 REQLQLLEEQHRAALAHSEEVTAS 2645
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 118 bits (296), Expect = 2e-26
Identities = 156/808 (19%), Positives = 346/808 (42%), Gaps = 120/808 (14%)
Query: 87 EDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELA 146
E+++ + ++ K+ +++G LK+E+ + E Q R ++ER E+E++ +L
Sbjct: 838 EENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLE 897
Query: 147 E-------TEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAK 199
E E T++ +++ EE +K L+Q +E L + + + D
Sbjct: 898 NRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVN 957
Query: 200 QVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDS 259
+ ++ + + INTL + + + EE +D +++ D
Sbjct: 958 MNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDK 1017
Query: 260 ERLMEQQGALLKRLAEADSE----KARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELS 315
++ +E + D+E + ++ L+Q+K+ E++++L+ + EK Q KT +L
Sbjct: 1018 KQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKN-ELQQMLESVIAEKEQLKT--DLK 1074
Query: 316 KSMESMRGHLQAQLR---SKEAENSRLCMQIKN--LERSGNQHKAEVEAIMEQLKELKQK 370
+++E M Q +LR + + + Q KN +++ G + + + E ++LK+K
Sbjct: 1075 ENIE-MTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRT-CDRLAEVEEKLKEK 1132
Query: 371 GDRDKESLKKAIRAQKERAE--KSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVV 428
+ +E ++ + Q+E +E K E L +L +K+L + + + N+
Sbjct: 1133 SQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENY 1192
Query: 429 KEKGDLELEIIVLNDRVTDLVNQQQTLEEKMRE--------------------DRDSLVE 468
+E + E VL + ++ L +RE + ++
Sbjct: 1193 EEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETID 1252
Query: 469 RLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMK 528
L R +E +A + + L+ S +++++ H E Q+L +VK + +
Sbjct: 1253 ELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLH-EEQELLPNVKEVSETQETMNELELL 1311
Query: 529 TRLEADEVAAQLERCDKENKILKD---EMNKEIEAARRQFQSQLADLQ--------QLPD 577
T + + L R + E L + E +EI++ ++ + L ++ QL +
Sbjct: 1312 TEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKE-RDNLKTIKEALEVKHDQLKE 1370
Query: 578 ILKITEAKLAEC---QDQLQGYERKNIDLTAIISD--------------------LRSRI 614
++ T AK+ E Q+Q + K+ + T I+S+ L R+
Sbjct: 1371 HIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRL 1430
Query: 615 EHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQ-------VIAKRE 667
+ D+++ ++ Q+ + L + D+L+ ++ A+++E + + ++E
Sbjct: 1431 QESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQE 1490
Query: 668 EAIHQSQLRLEEKTRECGTLARQLE-------------------------SAIEDARRQV 702
E I++ ++ L EK E T+ +QLE S +++ ++
Sbjct: 1491 ETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNEL 1550
Query: 703 EQTKEHALSKERAAQ---NKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRL 759
+Q KEH +K+ A Q +K+L+L +L ++ E+ + + +++ +R Q LQ +D+L
Sbjct: 1551 KQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEM-KRVQEALQIERDQL 1609
Query: 760 EQS-----ESTNRSMQNYVQFLKSSYAN 782
+++ S + QFLK + N
Sbjct: 1610 KENTKEIVAKMKESQEKEYQFLKMTAVN 1637
Score = 94.7 bits (234), Expect = 3e-19
Identities = 135/773 (17%), Positives = 330/773 (42%), Gaps = 117/773 (15%)
Query: 21 HVHIKKLPKPSATSSQKSHKRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMR 80
H +K+ + + Q+S + + ++N++ TK + P S L +
Sbjct: 1365 HDQLKEHIRETLAKIQESQSK--QEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIE 1422
Query: 81 LSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEV-KMQKGERQMAKRFLEERKEELE 139
+ LS +S H +M K+ D L L+SE ++++ +++ + LE EE
Sbjct: 1423 MLGLSKRLQES-HDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLET--EEEL 1479
Query: 140 EVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEA-EMDGAAAA 198
+VAH + E E T+ + ++E + + +QK+ L+ + L +K+ E E +
Sbjct: 1480 KVAHCCLK-EQEETINELRVNLSEKETEISTIQKQ-LEAINDKLQNKIQEIYEKEEQFNI 1537
Query: 199 KQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKED 258
KQ+ +++ + +LK K+ + L + +L+ + +E+ ++ +++E KE+
Sbjct: 1538 KQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKE---KEE 1594
Query: 259 SERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELL-----QEIQCEKAQAKTASE 313
+R+ E +L E E + Q+K+ + ++ QE CE K E
Sbjct: 1595 MKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFE 1654
Query: 314 LSKSMESMRGHLQAQLRSKEAENSRLCMQI-KNLE--RSGNQHKAEVEAIMEQLKELKQK 370
K L + E EN RL + +NLE RS + + ++ ++ E LK +
Sbjct: 1655 TQK----------LNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVER-- 1702
Query: 371 GDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKE 430
D+ KE+L++ I E+ E +L +++ E T++ R
Sbjct: 1703 -DQLKENLRETITRDLEKQE-----------ELKIVHMHLKEHQETIDKLRG-------- 1742
Query: 431 KGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKAS 490
+++++ ++ N Q+ LE N+ LKA
Sbjct: 1743 ---------IVSEKTNEISNMQKDLEHS-------------------------NDALKAQ 1768
Query: 491 FAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKIL 550
++++L AH+ +++ + ++ G++ ++ + + + A+L+ +E K
Sbjct: 1769 DLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKAN 1828
Query: 551 KDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDL 610
+ ++ ++ + Q ++++++QL +K L++ E +N++L
Sbjct: 1829 EHQL-ITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSK-------LEIENLNLA------ 1874
Query: 611 RSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVI------- 663
++ ++++ ++ ++ + L L+ D+L+ L+ T A+++E Q +
Sbjct: 1875 -QKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLS 1933
Query: 664 AKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSKERAAQ------ 717
+ +E + + + ++ EKT + + + L+ + ++ ++++++ ++ L R +
Sbjct: 1934 KEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSH 1993
Query: 718 ---NKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNR 767
N++ L+ Q + +R ++ L++++ ++ + R
Sbjct: 1994 KKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRR 2046
Score = 74.7 bits (182), Expect = 3e-13
Identities = 125/705 (17%), Positives = 295/705 (41%), Gaps = 90/705 (12%)
Query: 101 KKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEH--ENTVLRHN 158
+K+ L +++++++ + + + K+ + ++EL+ +E+ + + V +
Sbjct: 653 EKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDL 712
Query: 159 IERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMT 218
+ ++ E T LQK+ ++ +E EA + ++ +L + +L+ E Q
Sbjct: 713 LCNLELEGKITDLQKELNKEVEEN------EALREEVILLSELKSLPSEVERLRKEIQDK 766
Query: 219 CTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADS 278
+++ +T +K+ L ++ E R Q E+ + + D
Sbjct: 767 SEELHIITSEKDKLFSEVVHKES---------RVQGLLEEIGKTKDDLATTQSNYKSTDQ 817
Query: 279 EKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSR 338
E L D +++ + +L+E + + S+ ++ +S G L+ +L K E
Sbjct: 818 EFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQE 877
Query: 339 LCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQ 398
+++ Q K ++E L+ ++++ E L++ + K ++ ++ +
Sbjct: 878 KTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQL 937
Query: 399 LHVQLADKDLYVAEALSTLE---SWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTL 455
++D ++ T+ + + ++ + I L ++++ V++ +
Sbjct: 938 QESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHM 997
Query: 456 EEKMREDRDSLVERL----------HRQTAEYSAFKLENERLKAS---FAPMEDK----- 497
EE E +D +++ + T +A +NE ++ F+ +++K
Sbjct: 998 EENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQ 1057
Query: 498 -LNQAHLEVQQLKASVK-NYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMN 555
L E +QLK +K N E I+N + + RL DE+ K+ +I+ E N
Sbjct: 1058 MLESVIAEKEQLKTDLKENIEMTIENQE----ELRLLGDEL-------KKQQEIVAQEKN 1106
Query: 556 KEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIE 615
I+ + +L + D L E KL E QLQ +++ +++ +S+++ +I
Sbjct: 1107 HAIK--------KEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKI- 1157
Query: 616 HQGDKLEMAREKHQASQKENKQLSLKVDELER-KLEATSAQNIEFLQVIAKREEAIHQSQ 674
+++E + ++ +NK+L+L+ E ER +L +N E ++ I K + + + Q
Sbjct: 1158 ---NEIENLK-----NELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQ 1209
Query: 675 LRLEEKTRECGTLARQLESAIEDARRQVE----QTKEH---------ALSKERAAQNKIL 721
E + R++E+ + +++ KEH ++S++ A
Sbjct: 1210 KSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQ 1269
Query: 722 DLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTN 766
DLE ++ + E+ L Q L ++K+ E E+ N
Sbjct: 1270 DLEKSHTKLQEEIPVLHEE--------QELLPNVKEVSETQETMN 1306
Score = 73.6 bits (179), Expect = 7e-13
Identities = 169/873 (19%), Positives = 333/873 (38%), Gaps = 168/873 (19%)
Query: 67 ITPPSSEKLVSVMRLSDLS--------TEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVK 118
ITP S ++ ++ ++ + + + + + RY K+I L + + E +
Sbjct: 308 ITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETR 367
Query: 119 MQKGERQMAKRFLEER-------KEELEEVAHEL-------------AETEHENTVLRHN 158
Q E+ + LEE+ E++E + L A+ + T
Sbjct: 368 AQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGK 427
Query: 159 IERMKEEK-------DFTILQKKH------LQQEKECLMSK----------LVEAEMDGA 195
I +MK I K H L++ E + S+ L E E + A
Sbjct: 428 INKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPA 487
Query: 196 AAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHC 255
++ + L+ + D L +KE + KL +E N E+
Sbjct: 488 TKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKL---KEKNDLDEFEALERKT 544
Query: 256 KEDSERLMEQQGALLKRLA--------EADSEKARLLLLLQDKDKEVEELLQEIQCEKAQ 307
K+D E + + + LK L + ++E + + LL++K+ ++++L + I +K +
Sbjct: 545 KKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLE 604
Query: 308 AKTASELSKSMESMRGHLQAQ----------LRSK------EAENSRLCMQIKNLERSGN 351
+LS S+ES+ Q + L +K +EN L ++K L +
Sbjct: 605 -NIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYK 663
Query: 352 QHKAEVEAIMEQLK-ELKQKGDRDKE-----------------SLKKAIRAQKERAEKSE 393
Q + +++ QL+ + K + D +KE + K + E K
Sbjct: 664 QMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKIT 723
Query: 394 EYAEQLHVQLADKDLYVAEA--LSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQ 451
+ ++L+ ++ + + E LS L+S S ++ KE D E+ ++ L ++
Sbjct: 724 DLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSE 783
Query: 452 --------QQTLEE--KMREDRDSLVERLHRQTAEYSAFKL--------------ENERL 487
Q LEE K ++D + E+ FK ENER+
Sbjct: 784 VVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERM 843
Query: 488 KASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCD--- 544
+ + + + LK + + +V + E +++ QLE D
Sbjct: 844 NQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTL 903
Query: 545 ----KENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKL-----------AEC 589
+E ++ +++ + +E + Q + DL+QL + L+I +L +
Sbjct: 904 QTVEREKTLITEKLQQTLEEVKTLTQEK-DDLKQLQESLQIERDQLKSDIHDTVNMNIDT 962
Query: 590 QDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKL 649
Q+QL+ I+ L+S+I + + E ++ E +Q + +D K
Sbjct: 963 QEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGID----KK 1018
Query: 650 EATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAI-------EDARRQV 702
+ A+N + L K E I Q Q ++ +E L + LES I D + +
Sbjct: 1019 QDLEAKNTQTLTADVKDNEIIEQ-QRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENI 1077
Query: 703 EQTKEH---------ALSKER----AAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQ 749
E T E+ L K++ +N + E +LSRT L+++ + ++ Q
Sbjct: 1078 EMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQ 1137
Query: 750 SRLQDLKDRLEQSESTNRSMQNYVQFLKSSYAN 782
+ Q L + E+ + + N ++ LK+ N
Sbjct: 1138 EKQQQLLNVQEEMSEMQKKI-NEIENLKNELKN 1169
Score = 70.9 bits (172), Expect = 5e-12
Identities = 147/751 (19%), Positives = 316/751 (42%), Gaps = 122/751 (16%)
Query: 80 RLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELE 139
+LS++ +D ++ + K+ +++ + + + LK +V E Q +E+ K++++
Sbjct: 1803 KLSNMQ-KDLENSNAKLQEKIQELKANEHQLITLKKDVN----ETQKKVSEMEQLKKQIK 1857
Query: 140 EVAHELAETEHENT----VLRHNIERMK---EEKDFTILQKKHLQQEKECLMSKLVEAEM 192
+ + L++ E EN L N+E MK +E+D ++ L+ E++ L L E +
Sbjct: 1858 DQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKA 1917
Query: 193 DGAAAAKQVMAL-------KDTIGKLK---TEKQMTCTDINT-LTRQKELLLQKLSTFEE 241
+++ K+T+ KL+ +EK + +DI L + K+ L +K+ +E
Sbjct: 1918 RDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKI---QE 1974
Query: 242 TNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEI 301
+ LLR + S + + + L K+ + + + K++ E L+EI
Sbjct: 1975 LQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEI 2034
Query: 302 QCEKAQAKTASELSKSMESMRGHLQAQLR---SKEAENSRLCMQIKNLERSGNQHKAE-- 356
+ + + +S++ R A LR +++ +N ++ + K L G QH E
Sbjct: 2035 RIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPE-KRLLSDGQQHLTESL 2093
Query: 357 ---VEAIMEQLKELKQKGD------RDKESLKKAIRAQKE-----RAEKSEEYAEQLHVQ 402
I E LK + D R L+K I QKE +A S Y + H++
Sbjct: 2094 REKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIE 2153
Query: 403 LADKDLYVAEALSTLESWRSR--------YNQVVKEK-----GDLELEIIVLNDRVTDLV 449
L+ A ++E R Y +KE+ E++ I ++ +L+
Sbjct: 2154 ----KLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELL 2209
Query: 450 NQQQTLEE------------KMREDRDSLVERLHRQ--TAEYSAFKLENERLKASFAPME 495
+ Q L++ K+ ++ D +E + + +E+ + K E +++ ++ M
Sbjct: 2210 IKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMT 2269
Query: 496 DKLNQ---AHLEVQQLKASVKNYEGMI-------DNYKSQVMKTRLEADEVAAQLERCDK 545
L + ++++LK ++ I +N +M E +E +A + +
Sbjct: 2270 QFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISK--- 2326
Query: 546 ENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTA 605
E +++++ + + + + Q L K + A A+ Q + KN +T+
Sbjct: 2327 -------EWEQDLKSLKEKNEKLFKNYQTL----KTSLASGAQVNPTTQ--DNKNPHVTS 2373
Query: 606 IISDLRS-RIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIA 664
+ L + +I + L A+E A KE+K + +++++LE T+ +IA
Sbjct: 2374 RATQLTTEKIRELENSLHEAKES--AMHKESK-----IIKMQKELEVTN-------DIIA 2419
Query: 665 KREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLE 724
K + +H+S LE+ L ++ + + ++E K + + + E
Sbjct: 2420 KLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFE 2479
Query: 725 TQLSRTKTELSQ----LRRSRDDADRRYQSR 751
++S TK + +R R++ R Q++
Sbjct: 2480 KEISATKATVEYQKEVIRLLRENLRRSQQAQ 2510
Score = 68.9 bits (167), Expect = 2e-11
Identities = 153/748 (20%), Positives = 304/748 (40%), Gaps = 81/748 (10%)
Query: 79 MRLSDLSTEDD-DSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEE 137
++ DL +++ H + + ID L V ++ + + + + L+E+ +E
Sbjct: 1765 LKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQE 1824
Query: 138 LEEVAHELAETEHENTVLRHNIERM----KEEKDFTILQKKHLQQEKECLMSKLVEAEMD 193
L+ H+L + + + + M K+ KD ++ K L+ E L KL E
Sbjct: 1825 LKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSK-LEIENLNLAQKLHE---- 1879
Query: 194 GAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQ 253
K VM +D + +++ TL +++ L + L +ET RDL +Q
Sbjct: 1880 NLEEMKSVMKERDNLRRVE----------ETLKLERDQLKESL---QETK--ARDLEIQQ 1924
Query: 254 HCKEDSERLMEQQGALLKRLAEADSEKA-RLLLLLQDKDKEVEEL---LQEIQCEKAQAK 309
K + L ++ + +L E SEK ++ + +D DK +EL +QE+Q ++ Q
Sbjct: 1925 ELK-TARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLL 1983
Query: 310 TASELSKSMESMRGHLQAQLRSKEAEN-SRLCMQIKNLERSGNQHKA--EVEAIMEQLKE 366
E ++ + EA+N S +++ N + + H++ E+ + ++ E
Sbjct: 1984 RVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDE 2043
Query: 367 LKQKGDRDKESLK-------KAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLES 419
L+ R KESLK +R R ++ + + + L+D ++ E +L
Sbjct: 2044 LR----RIKESLKMERDQFIATLREMIARDRQNHQVKPEKRL-LSDGQQHLTE---SLRE 2095
Query: 420 WRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSA 479
SR +++K +++ LN DL + + +E + +L + QT
Sbjct: 2096 KCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANL-SLPYLQTKHIEK 2154
Query: 480 FKLENERLKASFAPMEDKLNQAHLEVQQLK----ASVKNYE-GMIDNYKSQ----VMKTR 530
N+R F + KL V ++K S+ +E ID + Q +
Sbjct: 2155 LFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQH 2214
Query: 531 LEAD-EVAAQLERCDKEN--------KILKDEMNKEIEAARRQFQSQLADLQQLPDILKI 581
L+ D +V ++ R K N +ILKD E + + +FQ L++ +++ L+
Sbjct: 2215 LQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEE 2274
Query: 582 TEAKLAECQDQLQGYERKNIDLTAIISDLRSRI----------EHQGDKLEMAREKHQAS 631
+ + G +++N + + + +RI E + + E+ S
Sbjct: 2275 WLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKS 2334
Query: 632 QKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQL 691
KE + K + + A+ AQ Q +QL E+ +L
Sbjct: 2335 LKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAK 2394
Query: 692 ESAIEDARRQVEQTKEHALSKERAA--QNKILDLETQLSRTKTELSQLRRSRDDADRRYQ 749
ESA+ + ++ KE ++ + A Q K+ + L +TK + L+ + Y+
Sbjct: 2395 ESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYK 2454
Query: 750 SRLQDLKDRLEQSESTNRSMQNYVQFLK 777
++DLK +L + + M+N +F K
Sbjct: 2455 EEIEDLKMKLVKIDL--EKMKNAKEFEK 2480
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 118 bits (296), Expect = 2e-26
Identities = 142/685 (20%), Positives = 301/685 (43%), Gaps = 89/685 (12%)
Query: 146 AETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSK------LVEAEMDGAAAAK 199
AETE E ++ R+KE + + ++K L+++ L+ + V+AE D A+
Sbjct: 845 AETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAE 904
Query: 200 Q------------VMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLS----TFEETN 243
+ +K+ +L+ E++M LT +K L + S ++
Sbjct: 905 ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNA----ELTAKKRKLEDECSELKKDIDDLE 960
Query: 244 RTLRDLLREQHCKEDS-ERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQ 302
TL + +E+H E+ + L E+ L + +A+ EK L + ++ L ++Q
Sbjct: 961 LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKAL-------QEAHQQALDDLQ 1013
Query: 303 CEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIME 362
E+ + + S+ +E L+ L ++ +LER+ + + +++ E
Sbjct: 1014 VEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVR-------MDLERAKRKLEGDLKLTQE 1066
Query: 363 QLKELKQKGDRDKESLKKA---IRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLES 419
+ +L+ + +E LKK I Q + E + A QL +L + + E LE+
Sbjct: 1067 SIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEA 1126
Query: 420 WRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSA 479
R+ +V K + DL E+ +++R+ + +++ +M + R++ +++ R E +
Sbjct: 1127 ERTARAKVEKLRSDLSRELEEISERLEE-AGGATSVQIEMNKKREAEFQKMRRDLEEAT- 1184
Query: 480 FKLENERLKASFAPMEDKLNQAHLE-VQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAA 538
L++E A+ L + H + V +L + N + + + + + +LE D+V +
Sbjct: 1185 --LQHEATAAA-------LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTS 1235
Query: 539 QLER-------CDKENKILKDEMNK---EIEAARR---QFQSQLADLQQLPDILKITEAK 585
+E+ +K ++ L+D+ N+ ++E A+R F +Q A LQ L +
Sbjct: 1236 NMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGEL---ARQ 1292
Query: 586 LAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDEL 645
L E + + R + T + DL+ ++E +G Q+++ + D L
Sbjct: 1293 LEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHD-------CDLL 1345
Query: 646 ERKLEATSAQNIEFLQVIAKREEAIHQSQLRLE----EKTRECGTLARQLESAIEDARRQ 701
+ E + E +V++K + Q + + E ++T E ++L ++DA
Sbjct: 1346 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEA 1405
Query: 702 VEQTKEHALSKERA---AQNKILDLETQLSRTKTELSQLRRSRDDADR---RYQSRLQDL 755
VE S E+ QN+I DL + R+ + L + + + D+ ++ + ++
Sbjct: 1406 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES 1465
Query: 756 KDRLEQSESTNRSMQNYVQFLKSSY 780
+ LE S+ RS+ + LK++Y
Sbjct: 1466 QSELESSQKEARSLSTELFKLKNAY 1490
Score = 118 bits (296), Expect = 2e-26
Identities = 158/738 (21%), Positives = 317/738 (42%), Gaps = 82/738 (11%)
Query: 101 KKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTV-LRHNI 159
KK+ + L+ E++ ++ R ++ + ELEE++ L E +V + N
Sbjct: 1108 KKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNK 1167
Query: 160 ERMKE-EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMT 218
+R E +K L++ LQ E + A+ A +Q+ L+ KL+ EK
Sbjct: 1168 KREAEFQKMRRDLEEATLQHEATAAALRKKHAD-SVAELGEQIDNLQRVKQKLEKEKSEF 1226
Query: 219 CTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCK-EDSER-----------LMEQQ 266
+++ +T E +++ + E+ +RTL D E K E+++R L +
Sbjct: 1227 KLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTEN 1286
Query: 267 GALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQ 326
G L ++L E ++ ++L +++E+L ++++ E+ +AK A L+ +++S R H
Sbjct: 1287 GELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLE-EEGKAKNA--LAHALQSAR-HDC 1342
Query: 327 AQLRSKEAENSRLCMQIKNLERSGNQH------KAEVEAIM--EQLKELKQKGDRDKESL 378
LR + E + +++ + N K E +AI E+L+E K+K + +
Sbjct: 1343 DLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDA 1402
Query: 379 KKAIRAQKERAEKSEEYAEQLHVQLADKDLYV------AEALST--------LESWRSRY 424
++A+ A + E+ +L ++ D + V A AL L W+ +Y
Sbjct: 1403 EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKY 1462
Query: 425 NQVV-------KEKGDLELEIIVLNDRVTDLVNQQQTLEEK---MREDRDSLVERLH--- 471
+ KE L E+ L + + + +T + + ++E+ L E+L
Sbjct: 1463 EESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGG 1522
Query: 472 ---------RQTAEYSAFKLEN--ERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMID 520
R+ E +L++ E +AS E K+ +A LE Q+KA ++ D
Sbjct: 1523 KNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKD 1582
Query: 521 NYKSQVMKTRLEA-DEVAAQLE-RCDKENKILKDEMNKEIEAARRQFQSQLADLQQLP-- 576
Q + D + L+ N++L+ + K++E + + QL+ ++
Sbjct: 1583 EEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLR--VKKKMEGDLNEMEIQLSHANRMAAE 1640
Query: 577 --DILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKE 634
+K ++ L + Q QL R N DL I+ + R +LE R + +++
Sbjct: 1641 AQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERS 1700
Query: 635 NKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESA 694
K ++ E +++ +QN + K E + Q Q +EE +EC + + A
Sbjct: 1701 RKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKA 1760
Query: 695 IEDARRQVEQTKE------HALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRY 748
I DA E+ K+ H ++ + I DL+ +L + E L+ + ++
Sbjct: 1761 ITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLD--EAEQIALKGGKKQL-QKL 1817
Query: 749 QSRLQDLKDRLEQSESTN 766
++R+++L+ LE + N
Sbjct: 1818 EARVRELEGELEAEQKRN 1835
Score = 99.0 bits (245), Expect = 2e-20
Identities = 144/651 (22%), Positives = 290/651 (44%), Gaps = 76/651 (11%)
Query: 128 KRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKL 187
KR LEE + +AH L H+ +LR E E K E + ++SK
Sbjct: 1318 KRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAK-----------AELQRVLSK- 1365
Query: 188 VEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLR 247
+E+ + A++ T +L+ K+ + E + K S+ E+T L+
Sbjct: 1366 ANSEVAQWRTKYETDAIQRT-EELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQ 1424
Query: 248 DLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQ 307
+ + + D ER AL K+ D +L + ++ EE E++ + +
Sbjct: 1425 NEIED--LMVDVERSNAAAAALDKKQRNFDK-------ILAEWKQKYEESQSELESSQKE 1475
Query: 308 AKTAS-ELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERS---GNQHKAEVEAIMEQ 363
A++ S EL K + L+ L + + EN L +I +L G ++ E+E + +Q
Sbjct: 1476 ARSLSTELFKLKNAYEESLE-HLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQ 1534
Query: 364 LK----ELKQKGDRDKESLK----KAIRAQKE----RAE---KSEEYAEQLHVQLADKDL 408
L+ EL+ + + SL+ K +RAQ E +AE K E E++ +
Sbjct: 1535 LEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQR 1594
Query: 409 YVAEALSTLESWRSRYNQVVKEK----GDL---ELEIIVLNDRVTDLVNQQQTLEEKMRE 461
V ++L++ N+V++ K GDL E+++ N + Q ++L+ +++
Sbjct: 1595 VVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKD 1654
Query: 462 DRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDN 521
+ L + + N+ LK + A +E + N E+++L+A V+ E
Sbjct: 1655 TQIQLDDAVRA-----------NDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKL 1703
Query: 522 YKSQVMKTRLEADEVAAQLERCDKENKILKDEMNK---EIEAARRQFQSQLADLQQLPDI 578
+ ++++T + +Q + K ++ ++ + E+E A ++ ++ ++
Sbjct: 1704 AEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITD 1763
Query: 579 LKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQL 638
+ +L + QD ER ++ I DL+ R++ E + + +K+ ++L
Sbjct: 1764 AAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLD------EAEQIALKGGKKQLQKL 1817
Query: 639 SLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTR---ECGTLARQLESAI 695
+V ELE +LEA +N E ++ + K E I + + EE + L +L+ +
Sbjct: 1818 EARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKV 1877
Query: 696 EDARRQVEQTKEHA---LSKERAAQNKILDLETQLSRTKTELSQLR-RSRD 742
+ +RQ E+ +E A LSK R Q+++ + E + ++++++LR +SRD
Sbjct: 1878 KAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRD 1928
Score = 97.1 bits (240), Expect = 6e-20
Identities = 111/532 (20%), Positives = 236/532 (44%), Gaps = 57/532 (10%)
Query: 280 KARLLLLLQD-KDKEVEELLQEIQCEKAQAKTASELSKSMES------MRGHLQAQLRSK 332
KA LL LL++ +D+ + ++ +Q + E K +E ++ +++A + K
Sbjct: 768 KAGLLGLLEEMRDERLSRIITRMQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVK 827
Query: 333 EAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKS 392
+L +IK L +S K ++ +K++ R KE+L+K+ +KE EK
Sbjct: 828 NWPWMKLYFKIKPLLKSAETEK--------EMATMKEEFGRIKETLEKSEARRKELEEKM 879
Query: 393 EEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTD----- 447
++ + D L V L R +Q++K K LE ++ +N+R+ D
Sbjct: 880 VSLLQEKN----DLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMN 935
Query: 448 --LVNQQQTLEEK---MREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMED------ 496
L +++ LE++ +++D D L L + E A + + + L A +++
Sbjct: 936 AELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLT 995
Query: 497 ----KLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKD 552
L +AH QQ ++ E +++ +K + D++ LE+ +K+ ++ +
Sbjct: 996 KEKKALQEAH---QQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQ-EKKVRMDLE 1051
Query: 553 EMNKEIEAARRQFQSQLADLQ----QLPDILKITEAKLAECQDQLQGYERKNIDLTAIIS 608
+++E + Q + DL+ QL + LK E + + +++ + + L +
Sbjct: 1052 RAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLK 1111
Query: 609 DLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREE 668
+ ++RIE ++LE R +K LS +++E+ +LE +++ KRE
Sbjct: 1112 ENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREA 1171
Query: 669 AIHQSQLRLEEKTRE----CGTLARQLESAIEDARRQVE--QTKEHALSKERAAQNKILD 722
+ + LEE T + L ++ ++ + Q++ Q + L KE++ LD
Sbjct: 1172 EFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELD 1231
Query: 723 LET----QLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQ 770
T Q+ + K L ++ R+ +D Y+ +L++ + L + +Q
Sbjct: 1232 DVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQ 1283
Score = 66.6 bits (161), Expect = 9e-11
Identities = 85/439 (19%), Positives = 198/439 (45%), Gaps = 35/439 (7%)
Query: 113 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 172
++ +++++K E Q A LEE + LE ++ + E ++ IER EKD + Q
Sbjct: 1531 VRKQLEVEKLELQSA---LEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ 1587
Query: 173 KKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELL 232
K Q + ++AE + +V+ +K + E ++ + N + + +
Sbjct: 1588 AKRNHQRVVDSLQTSLDAE---TRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQ 1644
Query: 233 LQKL-STFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKD 291
++ L S ++T L D +R +++ ++E++ LL +A+ E+ R ++ ++
Sbjct: 1645 VKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLL----QAELEELRAVVEQTERS 1700
Query: 292 KEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGN 351
+++ E QE+ + + + S+ + + +++ L ++E + +N E
Sbjct: 1701 RKLAE--QELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAK 1758
Query: 352 QHKAEVEAIMEQLKELKQKG---DRDKESLKKAIRAQKERAEKSEEYA-EQLHVQLADKD 407
+ + + E+LK+ + +R K+++++ I+ + R +++E+ A + QL +
Sbjct: 1759 KAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLE 1818
Query: 408 LYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLV 467
V E LE+ + R + VK E R+ +L Q + ++ + +D LV
Sbjct: 1819 ARVRELEGELEAEQKRNAESVKGMRKSER-------RIKELTYQTEEDKKNLLRLQD-LV 1870
Query: 468 ERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVM 527
++L + Y K E++ N + ++++ + E D +SQV
Sbjct: 1871 DKLQLKVKAY----------KRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVN 1920
Query: 528 KTRLEADEVAAQLERCDKE 546
K R ++ ++ A+ + D+E
Sbjct: 1921 KLRAKSRDIGAKQKMHDEE 1939
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 117 bits (294), Expect = 3e-26
Identities = 152/717 (21%), Positives = 303/717 (42%), Gaps = 64/717 (8%)
Query: 100 DKKIDSLMNAVGCLKSEVKMQKGER----QMAKRFLEERKEEL----EEVAHELAETEHE 151
++++ L G ++++ ++K R + L E++ E E +AH L E E +
Sbjct: 1003 EREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGK 1062
Query: 152 NTVLRH-------NIERMKEEKDFTILQKKHL-QQEKECLMSKLVEAEMDGAA--AAKQV 201
+ L I+ ++E + K+ L ++EKE ++E G ++
Sbjct: 1063 DQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKL 1122
Query: 202 MALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSER 261
AL+ + KL+ + Q ++L R E + + TL+ L E+ ++
Sbjct: 1123 EALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEK-----AQE 1177
Query: 262 LMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESM 321
L Q AL A A E A +QD K +E ++ + +A+ + L S+E
Sbjct: 1178 LGHSQSAL----ASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEE 1233
Query: 322 RGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKA 381
L Q+ KE E+ L + + + + + + + +L++
Sbjct: 1234 VSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREE 1293
Query: 382 IRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVL 441
+++ +E AEK +E L +L + E L++W+ ++ Q + L+LE
Sbjct: 1294 VQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTST 1353
Query: 442 NDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYS--------AFKLENERLKASFAP 493
V++L+ + ++ E + E+ HR+ E S A L +R P
Sbjct: 1354 QALVSELLPAKHLCQQLQAE--QAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIP 1411
Query: 494 MEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDE 553
+ K+ + QQL+A +Y + K L A+E ER + + L+
Sbjct: 1412 LRQKVAEQERTAQQLRAEKASYAEQLSMLKK---AHGLLAEENRGLGERANLGRQFLE-- 1466
Query: 554 MNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSR 613
E++ AR ++ +Q+L + E +LAE Q + Q R+ +TA + +
Sbjct: 1467 --VELDQAREKY------VQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVK 1518
Query: 614 IEHQGDKLEMAREKHQASQKE----NKQLSLKVDELERKL----EATSAQNIEFLQVIAK 665
+ + + + R+K A ++ ++ + +V+EL +KL +A+ Q + V A+
Sbjct: 1519 VLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQ 1578
Query: 666 REEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLET 725
E+ ++Q RL+ + E Q E A E + Q+E+ K H +K++ Q +L+
Sbjct: 1579 GGESQQEAQ-RLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQ----ELQE 1633
Query: 726 QLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSSYAN 782
QL + + + R +A+ R LQ + +++E T R + V+ L++ A+
Sbjct: 1634 QLRSLEQLQKENKELRAEAE-RLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAH 1689
Score = 103 bits (256), Expect = 8e-22
Identities = 156/760 (20%), Positives = 308/760 (40%), Gaps = 110/760 (14%)
Query: 77 SVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKE 136
S+ LS E + + R ++ SL + + L + ++ Q E K ++ KE
Sbjct: 474 SISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLK---QQAKE 530
Query: 137 ELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAA 196
+ ++A L + E + LRH +E++ Q K + +++E ++ A+ A
Sbjct: 531 KQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEA--TRQDHAQQLATA 588
Query: 197 AAKQVMALKDTIGKLKTEKQMTCTDINTLTRQK----ELLLQKLSTFEETNRTLR-DLLR 251
A ++ +L++ LK + L ++K E+L Q+L E + + + +
Sbjct: 589 AEEREASLRERDAALK--------QLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQ 640
Query: 252 EQHCKEDSERLMEQQGALLKRLA----EADSEKARLLLLLQDKDKEVEELLQEIQCEKAQ 307
Q K + R +E+ A ++ EA ++ A L L L+ + ++ E ++
Sbjct: 641 AQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATE-------KERV 693
Query: 308 AKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKEL 367
A+ +L + +++++ L+ S E E R ++ +R ++ KAE +++EQ K
Sbjct: 694 AQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRE 753
Query: 368 KQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLAD-------KDLYVAEALSTLESW 420
+++ + ++ K ++ E + E L +LA+ + + + + +W
Sbjct: 754 RKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAW 813
Query: 421 RSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAF 480
R RY +E+ Q TL+E+ + R L E + S
Sbjct: 814 RERYEDSQQEEAQYG----------AMFQEQLMTLKEECEKARQELQEAKEKVAGIESHS 863
Query: 481 KLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQL 540
+L+ R + A + L +A +VQ+ + + + + ++ T E + +
Sbjct: 864 ELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLV 923
Query: 541 ERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKN 600
+ ++ + E+ KE A + L + Q + Q LQ ER+
Sbjct: 924 RKAGEQQETASRELVKEPARAGDRQPEWLEEQQ---------GRQFCSTQAALQAMEREA 974
Query: 601 IDLTAIISDLRSRI-EHQGDKLE----MAREKHQASQKENK-QLSLKVD-----ELERKL 649
+ + LR+ + E QG + E RE + +Q+ + Q L ++ ELE +L
Sbjct: 975 EQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRL 1034
Query: 650 E-ATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESA----IEDARRQVEQ 704
+ A + Q +EF A +EA+ + E K +E L R LE+A +E+ R+ V+Q
Sbjct: 1035 QNALNEQRVEF----ATLQEALAHALTEKEGKDQELAKL-RGLEAAQIKELEELRQTVKQ 1089
Query: 705 TKEHALSKER------------------------AAQNKILDLETQLSRTKTELSQLRRS 740
KE KE+ A + ++ LE Q + + + L RS
Sbjct: 1090 LKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERS 1149
Query: 741 ----------RDDADRRYQSRLQDLKDRLEQSESTNRSMQ 770
RD A Q +L++ L S+S S Q
Sbjct: 1150 LEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQ 1189
Score = 92.0 bits (227), Expect = 2e-18
Identities = 161/719 (22%), Positives = 292/719 (40%), Gaps = 92/719 (12%)
Query: 124 RQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECL 183
R++ K+ +ER +E+ ELAE T I M++ D L + +Q L
Sbjct: 217 RRLKKQLADERSNR-DELELELAENRKLLTEKDAQIAMMQQRIDRLALLNE--KQAASPL 273
Query: 184 MSKLVEAEMDGAAAAKQVMALKDTIGK---LKTEKQMTCTDINTLTRQKELLLQKLSTFE 240
K +E D + M L +T+ + LKTEK IN L+ + L KL F
Sbjct: 274 EPKELEELRDKNESL--TMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFA 331
Query: 241 ETNRTLRDLLR---EQHCKEDSERLMEQQGALLKRLAEADSEKARL---LLLLQDKDKEV 294
+ L+D L E+H K E L E+Q L K L+ A +K L +LQ K ++
Sbjct: 332 SHLQQLQDALNELTEEHSKATQEWL-EKQAQLEKELSAALQDKKCLEEKNEILQGKLSQL 390
Query: 295 EELLQEIQCEKAQAK-----------TASELSKSMESMRGHLQAQLRSKEAENSRLCMQI 343
EE L ++Q Q K T + + ++ + LQA++ E E + +
Sbjct: 391 EEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQ--QEA 448
Query: 344 KNLERSGN--QHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKER------------- 388
K L G+ + K ++ +++ L+ + KE L++A +A R
Sbjct: 449 KLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELT 508
Query: 389 -----AEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKE------------K 431
++ ++ L Q +K +A+ L E V++ K
Sbjct: 509 TLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLK 568
Query: 432 GDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASF 491
E + D L + E +RE RD+ +++L E +A + E L+
Sbjct: 569 EVAEKQEATRQDHAQQLATAAEEREASLRE-RDAALKQLEALEKEKAA---KLEILQQQL 624
Query: 492 APMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILK 551
+ + A V Q + ++ ++ V R E E AQ+ + + L+
Sbjct: 625 QVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQ---LR 681
Query: 552 DEMNKEIEAAR-RQFQSQLAD-LQQLPDILKITEAKLAE----CQDQLQGYERKNIDLTA 605
E K E R Q + QL + LQ L + LK+T+ L E D L+ +R +L A
Sbjct: 682 SEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKA 741
Query: 606 IISDLRSRIEHQGDKLEMAREKHQASQKENKQL----SLKVDELERKL-EATSAQNI--- 657
L + + + +LE R + + +QL + + L R+L EA +AQ+
Sbjct: 742 ETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAES 801
Query: 658 ---EFLQVIAKREEAIHQSQLRLEEKTRECGTLARQ----LESAIEDARRQVEQTKEHAL 710
+ ++ +A E SQ ++ + G + ++ L+ E AR+++++ KE
Sbjct: 802 ECEQLVKEVAAWRERYEDSQ----QEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVA 857
Query: 711 SKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSM 769
E ++ +I + +L+ L++ + + + R Q DL E+ +T++ +
Sbjct: 858 GIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEV 916
Score = 84.3 bits (207), Expect = 4e-16
Identities = 120/606 (19%), Positives = 247/606 (40%), Gaps = 69/606 (11%)
Query: 98 RYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRH 157
+ ++ DSL ++ ++ + + + LEE+ +EL LA + E R
Sbjct: 1138 KQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRT 1197
Query: 158 NIE---RMKEEKDFTILQKKHLQQEKECLMSKLVE---------AEMDGAAAAKQVMALK 205
++ + ++E + + + + K L+S L E E +G + + + +
Sbjct: 1198 KVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMA 1257
Query: 206 DTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSER---- 261
++ K E+++ T + ++ S E ++LR+ +Q ++ R
Sbjct: 1258 ESEKSQKLEERLRLLQAETASNSAR-AAERSSALREEVQSLREEAEKQRVASENLRQELT 1316
Query: 262 ----LMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEI-----QCEKAQAKTAS 312
E+ G LK E +K + L LQ + + L+ E+ C++ QA+ A+
Sbjct: 1317 SQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAA 1376
Query: 313 ELSKSMESMR------GHLQAQLRSKEAENSRLC---MQIKNLERSGNQHKAEVEAIMEQ 363
+ E + G L+A+L + E L ++ ER+ Q +AE + EQ
Sbjct: 1377 AEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQ 1436
Query: 364 LKELKQ---------KGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEAL 414
L LK+ +G ++ +L + + E + E+Y ++L AD + +AE
Sbjct: 1437 LSMLKKAHGLLAEENRGLGERANLGRQF-LEVELDQAREKYVQELAAVRADAETRLAEVQ 1495
Query: 415 STLESWRSRYNQVVKEKGDLELEIIVLNDRVTD----LVNQQQTLEEKMREDRDSLVERL 470
+S + + +++++ R + L Q + LE RE + E
Sbjct: 1496 REAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELS 1555
Query: 471 HRQTAEYSAFKLENERLKASFA---PMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVM 527
+ A K++ ++LKA A + + + ++ +L+A + E ++YK Q+
Sbjct: 1556 KKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQME 1615
Query: 528 KTRL----------EADEVAAQLERCDKENKILKDE---MNKEIEAARRQFQSQLADLQQ 574
K + E E LE+ KENK L+ E + E++ A + + +
Sbjct: 1616 KAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRH 1675
Query: 575 LPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKE 634
L ++ EA++A QL+ + + A L+SR +L+++ + S +E
Sbjct: 1676 LTAQVRSLEAQVAHADQQLRDLGKFQVATDA----LKSREPQAKPQLDLSIDSLDLSCEE 1731
Query: 635 NKQLSL 640
LS+
Sbjct: 1732 GTPLSI 1737
Score = 67.0 bits (162), Expect = 7e-11
Identities = 88/445 (19%), Positives = 174/445 (39%), Gaps = 75/445 (16%)
Query: 382 IRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVL 441
+R K++ ++L ++LA+ + E + + + R +++ +L
Sbjct: 216 MRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLA-----------LL 264
Query: 442 NDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQA 501
N++ + + LEE +R+ +SL RLH + K E ++ + ++
Sbjct: 265 NEKQAASPLEPKELEE-LRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDL 323
Query: 502 HLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLER---CDKENKILKDEMNKEI 558
++++ + ++ + ++ + K E E AQLE+ ++K +E N+ +
Sbjct: 324 SFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEIL 383
Query: 559 EAARRQFQSQLADLQQLP--------------DILKITEAKLAECQDQLQG--------- 595
+ Q + L+ LQ P + LK A LA QLQ
Sbjct: 384 QGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETER 443
Query: 596 -------------YERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKV 642
+E + L+++I+DL+S I + E E QASQ +L+ +V
Sbjct: 444 GQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKE---ELEQASQAHGARLTAQV 500
Query: 643 DELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQV 702
L +L +A I ++++ + + + +EK + +Q E A + R QV
Sbjct: 501 ASLTSELTTLNA-------TIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQV 553
Query: 703 EQTKEHALSKERAAQNKI-------LDLETQLSRTKTELSQLRRSRDDA-------DRRY 748
EQ KE+ + D QL+ E R RD A ++
Sbjct: 554 EQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEK 613
Query: 749 QSRLQDLKDRLEQSESTNRSMQNYV 773
++L+ L+ +L+ + S Q V
Sbjct: 614 AAKLEILQQQLQVANEARDSAQTSV 638
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 117 bits (292), Expect = 6e-26
Identities = 164/701 (23%), Positives = 298/701 (42%), Gaps = 104/701 (14%)
Query: 112 CLKSEVKMQKGERQMAKRFL-------EERKEELEEVAHELAETEHENTVLRHNIERMKE 164
C + +K +G+R+ + L EER +EL+ + ++ + E +TVL ++ +
Sbjct: 1571 CQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQ 1630
Query: 165 EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINT 224
E Q + LQ++KE L L + +++M K+ I L+ ++
Sbjct: 1631 EVKSQREQIEELQRQKEHLTQDLERRD-------QELMLQKERIQVLEDQR--------- 1674
Query: 225 LTRQKELLLQKLSTFEETNRTLRDLLREQHCKED--SERLMEQQGALLKRLAEADSEKAR 282
TRQ ++L + L E+ +LR+ RE + ER E +G + + K
Sbjct: 1675 -TRQTKILEEDL---EQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMK-- 1728
Query: 283 LLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQ 342
L+L+DK+KEVE C++ EL +E LQ L K E S L
Sbjct: 1729 --LILRDKEKEVE-------CQQEHIHELQELKDQLEQ---QLQG-LHRKVGETSLLL-- 1773
Query: 343 IKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAI-RAQKERAEKSEEY--AEQL 399
+Q + E+ + +QL+E +++G+ ++SL+ + AQ+ A++ +E +Q
Sbjct: 1774 --------SQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQE 1825
Query: 400 HVQLADKDLYVAEALSTLESWRSRYNQVVKEKGD-----------LELEIIVLNDRVTDL 448
Q ++ V E L+ + + +KE+ LE E+ V RV L
Sbjct: 1826 QQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQAL 1885
Query: 449 VNQQQTLEEKMREDRDSLVERLHRQTAEYS-AFKLENERLKASFAPMEDKLNQAHLEVQQ 507
L + RE +L+ L +Q AE + ++E L+ S+ + L + E++
Sbjct: 1886 EEVLGDLRAESREQEKALL-ALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEA 1944
Query: 508 LKASVKNYEGMIDNYKSQVMKTRLEADEVA---AQLERCDKENKILKD-EMNKEIEAARR 563
L+A E ++ + + R EA + A A KE +L+ E+++ +EA+
Sbjct: 1945 LRA-----ESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTA 1999
Query: 564 QFQSQL----ADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGD 619
Q+ L A +QL + L+I E E QDQ Y+ L ++ + HQ +
Sbjct: 2000 TLQASLDACQAHSRQLEEALRIQE---GEIQDQDLRYQEDVQQLQQALAQRDEELRHQQE 2056
Query: 620 KLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEE 679
+ E EK A + + + K + + + E + I +++ + QL L +
Sbjct: 2057 R-EQLLEKSLAQRVQENMIQEKQNLGQEREE----------EEIRGLHQSVRELQLTLAQ 2105
Query: 680 KTRECGTLARQLESAIEDARRQVEQ-TKEHALSKERAAQNKILDLETQLSRTKTELSQLR 738
K +E LE R +E H S K+ LE +L R L
Sbjct: 2106 KEQEI------LELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAAL 2159
Query: 739 RSRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSS 779
R + + ++ + QDL L Q++++ S+Q FL++S
Sbjct: 2160 RQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQAS 2200
Score = 112 bits (280), Expect = 1e-24
Identities = 160/707 (22%), Positives = 296/707 (41%), Gaps = 78/707 (11%)
Query: 135 KEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDG 194
+E+L L E R + ++E+ + + Q K LQ+ L L E E +
Sbjct: 1378 EEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEV 1437
Query: 195 AAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQH 254
Q+ L+ K ++ D+ ++ +L +++ E+ L L
Sbjct: 1438 ETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHL--PMA 1495
Query: 255 CKEDSERLMEQQGALLKRLAEADSEKAR-----LLLLLQDKDKEVEELLQEIQCEKAQAK 309
+E ++L Q+ + R E D E R LL L+ KD+ +E ++Q K Q
Sbjct: 1496 VQEREQKLTVQREQI--RELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLV 1553
Query: 310 TASELSKSMESMRGHLQAQLRS-KEAENSRLCMQIK--NLERSGNQHKAEVEAIMEQLKE 366
T L+ +E ++ Q + KE E R ++ +L + E++A Q+ +
Sbjct: 1554 TLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHD 1613
Query: 367 LKQKGD---RDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKD---LYVAEALSTLESW 420
L+ R+ + + +++Q+E+ E+ + E L L +D + E + LE
Sbjct: 1614 LESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQ 1673
Query: 421 RSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAF 480
R+R ++++E DLE + L +R +L Q+Q ++E+ E + + R + E+
Sbjct: 1674 RTRQTKILEE--DLEQIKLSLRERGRELTTQRQLMQERAEEGKGP--SKAQRGSLEHMKL 1729
Query: 481 KLENERLKASFAPMEDKLNQAHL-EVQQLKASVKNYEGMIDNYKSQVMKTRL-------E 532
L ++ E + Q H+ E+Q+LK + E + +V +T L E
Sbjct: 1730 ILRDKE-------KEVECQQEHIHELQELKDQL---EQQLQGLHRKVGETSLLLSQREQE 1779
Query: 533 ADEVAAQLERCDKENKILKDEMNKEIEAARR---QFQSQLADLQQLPDILKITEAKLAEC 589
+ QL+ ++ ++ + + +++ A+R Q +L LQQ + E ++ E
Sbjct: 1780 IVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEK 1839
Query: 590 QDQLQG-YERKNIDLT---AIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDEL 645
D LQG E+ ++ L + D + + ++L + + QA ++ L + E
Sbjct: 1840 ADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQ 1899
Query: 646 ERKLEATSAQNIEFLQVIAKREEAIHQSQLR----LEEKTRECGTLARQLESAI--EDAR 699
E+ L A Q E Q A+ S L+ L+E+ +E L + +S+ E+A
Sbjct: 1900 EKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAA 1959
Query: 700 RQVEQTKEHALSKERAA-QNKILDL--ETQLSRT-KTELSQLRRSRD------------- 742
R + + AL K AA Q K L + +LSR+ + + L+ S D
Sbjct: 1960 RARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEAL 2019
Query: 743 --------DADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSSYA 781
D D RYQ +Q L+ L Q + R Q Q L+ S A
Sbjct: 2020 RIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLA 2066
Score = 104 bits (260), Expect = 3e-22
Identities = 172/852 (20%), Positives = 364/852 (42%), Gaps = 136/852 (15%)
Query: 23 HIKKLPKPSATSSQKSHKRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLS 82
H L S+ SQ ++ K T+ RSV + + L ++ V++++
Sbjct: 365 HENSLELDSSIFSQFDYQDADKALTLV--RSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ 422
Query: 83 -DLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEV 141
D E+ + ++ + + D+L L+ EV ER++ ++ EE +++LE +
Sbjct: 423 HDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVL 482
Query: 142 AHELAETEHENTVLR---HNIERMKEEKDFTILQKKHLQ-QEKECLMSKLVEAEMDGAAA 197
E N L+ + + KEE+ ++ HL +E+E L L+ E + +
Sbjct: 483 EQEAWRLRRVNVELQLQGDSAQGQKEEQQ----EELHLAVRERERLQEMLMGLEAKQSES 538
Query: 198 AKQVMALKDTI------GKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLR 251
+++ L++ + G+L ++Q T++ + E + +LS+ E T +T LR
Sbjct: 539 LSELITLREALESSHLEGELLRQEQ---TEVTAALARAEQSIAELSSSENTLKTEVADLR 595
Query: 252 EQHCKED--SERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAK 309
K +E L + L ++L + + E + + + E+ +Q + A+A+
Sbjct: 596 AAAVKLSALNEALALDKVGLNQQLLQLEEENQSVC----SRMEAAEQARNALQVDLAEAE 651
Query: 310 TASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKN-------LERSGNQHKAEVEAIME 362
E ++ HL+AQL+ E + L +++ +++ ++ + + EA
Sbjct: 652 KRRE---ALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATT 708
Query: 363 QLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLY-VAEALSTLESWR 421
QL++L Q+ R +E L +A+ Q++ A E+ A ++ +Q ++D +AE L L S +
Sbjct: 709 QLEQLHQEAKRQEEVLARAV--QEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAK 766
Query: 422 ----------SRYNQVVK-EKGDLELEI-------IVLNDRVTDLVNQQQTLEEKMREDR 463
+ N V++ KG LE++I V+ V L + T + ++R
Sbjct: 767 ELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQER 826
Query: 464 DSLVERL-----------------------------------HRQTAEYSAFKLENERLK 488
D+ +L H+Q + LE E+++
Sbjct: 827 DAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKME 886
Query: 489 ASFAPMEDKLN----QAHLEVQQLKASVKNYEGMIDNYKSQV------MKTRLEADEVAA 538
E + QA E ++ +A + ++ K +V ++T+ E + +
Sbjct: 887 LEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQ 946
Query: 539 QLERCDKENKI--LKDEMNKEIEAARRQFQSQLADLQ-QLPDILKITEAKLAECQDQLQG 595
QLER ++ K+ LK++ I Q+QL + Q +L + + LA Q++
Sbjct: 947 QLERLRQDMKVQKLKEQETTGI------LQTQLQEAQRELKEAARQHRDDLAALQEESSS 1000
Query: 596 YERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQ 655
+ +DL + DL+S++ Q D + ++ Q +E ++ + ELER+ + +
Sbjct: 1001 LLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLS 1060
Query: 656 NIEFLQ--VIAKREEAIHQSQL-RLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSK 712
+E Q ++ + ++I Q +L L + +E ++L + +E R++V++ + L++
Sbjct: 1061 LMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQ 1120
Query: 713 ER---------------------AAQNKILDLETQLSRTKTELSQLRRSRDDADR-RYQS 750
E A + K L+ +L T+++L L + ++ + Q+
Sbjct: 1121 EAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQA 1180
Query: 751 RLQDLKDRLEQS 762
+L L L+Q+
Sbjct: 1181 QLASLYSALQQA 1192
Score = 100 bits (248), Expect = 7e-21
Identities = 159/798 (19%), Positives = 324/798 (40%), Gaps = 121/798 (15%)
Query: 89 DDSGHCKMNRYDKKIDSL--MNAVGCLKSEVKMQKGERQMAKR---------------FL 131
D S + R D K+ L G L+++++ + E + A R L
Sbjct: 943 DASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLL 1002
Query: 132 EER---KEELEEVAHELAETEHENTVLRHNI-ERMKEEKDFTILQKKHLQQEKECLMSKL 187
+++ ++++E++ +L + ++ + E+++E +++ +QK+ L++EK L L
Sbjct: 1003 QDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKE-LEREKASLTLSL 1061
Query: 188 VEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLR 247
+E E + + + L+ + Q + L+ Q ELL Q++ E
Sbjct: 1062 MEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQE 1121
Query: 248 DLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQC---E 304
L E+ ++ + EQQ L L +++ A+L L L+ + ++E L E Q
Sbjct: 1122 AQLLEEL---EASHITEQQ--LRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQA 1176
Query: 305 KAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKA--------- 355
+AQA+ AS S +++ +++ +S + LE N ++
Sbjct: 1177 QAQAQLASLYSALQQALGSVCESRPELSGGGDS--APSVWGLEPDQNGARSLFKRGPLLT 1234
Query: 356 --EVEAIMEQLKELKQ---KGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYV 410
EA+ L +L Q K + ++ L+ ++ +ER +E Q+H +L D +
Sbjct: 1235 ALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQL 1294
Query: 411 AEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQ------QQTLEEKMREDRD 464
++ W + N + E +L + L R+ Q ++ L + +E+
Sbjct: 1295 SQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLT 1354
Query: 465 SLVERLHRQTAE------------------YSAFKLENERLKASFAPMEDKLNQAHLEVQ 506
+ VE L E SA KL+NE +++ + Q L+V
Sbjct: 1355 AQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVA 1414
Query: 507 QLKASVKNY----------EGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNK 556
Q KA +N E ++ + Q+ + + + A LE + K + N+
Sbjct: 1415 QGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLK----KRNQ 1470
Query: 557 EIEAARRQFQSQ---LADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSR 613
E++ + Q Q + L+ LP ++ E KL ++Q++ E+ ++
Sbjct: 1471 EVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLE 1530
Query: 614 IEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREE---AI 670
+E + +E R + Q +K+ L ELE Q ++ +RE A+
Sbjct: 1531 LEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVAL 1590
Query: 671 HQSQLRLEEKTRE--------------CGTLARQLESAIEDARRQVEQTKEHALSKERAA 716
L LEE+++E LAR+L+ ++ + Q EQ +E KE
Sbjct: 1591 THLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLT 1650
Query: 717 QN-------------KILDLETQLSR----TKTELSQLRRSRDDADRRYQSRLQDLKDRL 759
Q+ +I LE Q +R + +L Q++ S + R ++ Q +++R
Sbjct: 1651 QDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERA 1710
Query: 760 EQSESTNRSMQNYVQFLK 777
E+ + +++ + ++ +K
Sbjct: 1711 EEGKGPSKAQRGSLEHMK 1728
Score = 99.0 bits (245), Expect = 2e-20
Identities = 130/617 (21%), Positives = 261/617 (42%), Gaps = 61/617 (9%)
Query: 200 QVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDS 259
QV L++ + + EK T++ L RQ ++ S +E +L L E H E
Sbjct: 1265 QVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELH--ETM 1322
Query: 260 ERLMEQ-QGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSM 318
L + + A L+R+ EA E+ L ++ +VE L + +AQA A L + +
Sbjct: 1323 ASLQSRLRRAELQRM-EAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDL 1381
Query: 319 ESMRGHLQAQLRSKEAENSR-----------------LCMQIKNLERSGNQHKAEVEAIM 361
+ R L+ + E+E R L + L ++ + + EVE +
Sbjct: 1382 RTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLR 1441
Query: 362 EQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWR 421
Q++EL+++ + K +L+ K+R ++ + EQ +Q +K V E L R
Sbjct: 1442 GQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQ--IQELEKCRSVLEHLPMAVQER 1499
Query: 422 SRYNQVVKE-----KGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAE 476
+ V +E + D E + VL ++ +L + Q +E + + +D L ++L T E
Sbjct: 1500 EQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQD-LKKQL--VTLE 1556
Query: 477 YSAFKLENERLKAS-----FAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRL 531
A +LE K +E + + + L ++ + SQ+
Sbjct: 1557 CLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLES 1616
Query: 532 EADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQD 591
+ +A +L+ D+E K ++IE +RQ + DL++ L + + ++ +D
Sbjct: 1617 HSTVLARELQERDQEVK----SQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLED 1672
Query: 592 QLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENK-----------QLSL 640
Q R+ L + ++ + +G +L R+ Q +E K + L
Sbjct: 1673 Q---RTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKL 1729
Query: 641 KVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARR 700
+ + E+++E E + + + ++ + Q L K E L Q E I ++
Sbjct: 1730 ILRDKEKEVECQQ----EHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQ 1785
Query: 701 QVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDA---DRRYQSRLQDLKD 757
Q+++ +E KE++ Q+++ + + L++ EL L++ + A + R + + L+
Sbjct: 1786 QLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQG 1845
Query: 758 RLEQSESTNRSMQNYVQ 774
LEQ+ T + +Q
Sbjct: 1846 ALEQAHMTLKERHGELQ 1862
Score = 80.9 bits (198), Expect = 4e-15
Identities = 140/679 (20%), Positives = 272/679 (40%), Gaps = 109/679 (16%)
Query: 134 RKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMD 193
+ +ELE+ AHE ++ + ++K + D L+K LQ L + L +++
Sbjct: 252 KTQELEKEAHERSQ----------ELIQLKSQGD---LEKAELQDRVTELSALLTQSQKQ 298
Query: 194 GAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLRE- 252
K + AL++T+ L+T +L+R + +KLS + + ++ E
Sbjct: 299 NEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQE--EKLSLQQVIKDITQVMVEEG 356
Query: 253 QHCKEDS--ERLMEQQGALLKRLAEADSEKARLLL--LLQDKDKEVEELLQEIQCEKAQA 308
+ + S E +E ++ + D++KA L+ +L + + V++L Q++ +
Sbjct: 357 DNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAV 416
Query: 309 KTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELK 368
+ E L+ +L+ E L Q +L+ EV+++
Sbjct: 417 NLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQ-------GEVDSL-------- 461
Query: 369 QKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVV 428
+++E L+KA +++ E E+ A +L + L A E + + V
Sbjct: 462 ---SKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAV 518
Query: 429 KEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLK 488
+E+ L+ ++ L + ++ +++ TL E + E E L ++ E +A E+
Sbjct: 519 RERERLQEMLMGLEAKQSESLSELITLREAL-ESSHLEGELLRQEQTEVTAALARAEQ-- 575
Query: 489 ASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAA--QLERCDKE 546
S A + N EV L+A+ K + L D+V QL + ++E
Sbjct: 576 -SIAELSSSENTLKTEVADLRAAA---------VKLSALNEALALDKVGLNQQLLQLEEE 625
Query: 547 NKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAI 606
N+ + M + E AR Q LA+ ++ + L K + QLQ E +L A
Sbjct: 626 NQSVCSRM-EAAEQARNALQVDLAEAEKRREALW---EKNTHLEAQLQKAEEAGAELQAD 681
Query: 607 ISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKR 666
+ D+ Q+E +++ K+ E + EA + Q + Q ++
Sbjct: 682 LRDI---------------------QEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQ 720
Query: 667 EEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSK--------ERAAQN 718
EE + ++ E RE L +L++ D + EQ + + +K E QN
Sbjct: 721 EEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQN 780
Query: 719 KILD-----LETQLS------------------RTKTELSQLRRSRDDADRRYQSRLQDL 755
+++ LE Q+ TE SQ + RD A R+ Q+
Sbjct: 781 SVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEG 840
Query: 756 KDRLEQSESTNRSMQNYVQ 774
K LEQ ++ + N ++
Sbjct: 841 KTALEQQKAAHEKEVNQLR 859
Score = 72.4 bits (176), Expect = 2e-12
Identities = 134/693 (19%), Positives = 270/693 (38%), Gaps = 94/693 (13%)
Query: 72 SEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFL 131
S++ ++ L E + G K ++D A+ E++ + E+Q A+
Sbjct: 1774 SQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQG-Q 1832
Query: 132 EERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAE 191
EER +E + E H RH LQ KE ++ +E E
Sbjct: 1833 EERVKEKADALQGALEQAHMTLKERHG----------------ELQDHKE--QARRLEEE 1874
Query: 192 MDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLR 251
+ A ++V AL++ +G L+ E +R++E L L
Sbjct: 1875 L--AVEGRRVQALEEVLGDLRAE-----------SREQEKAL---------------LAL 1906
Query: 252 EQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTA 311
+Q C E ++ + AL +A + +L+++D+E+E L E Q + Q + A
Sbjct: 1907 QQQCAEQAQEHEVETRALQDSWLQAQA-------VLKERDQELEALRAESQSSRHQEEAA 1959
Query: 312 SELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELK--- 368
+++++ G A L+ KE ++LE S +A ++A ++L+
Sbjct: 1960 RARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEAL 2019
Query: 369 --QKG---DRDKESLKKAIRAQKERAEKSEEYA-EQLHVQLADKDLYVAEALSTLESWRS 422
Q+G D+D + + Q+ A++ EE +Q QL +K L + +
Sbjct: 2020 RIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSL-AQRVQENMIQEKQ 2078
Query: 423 RYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTA---EYSA 479
Q +E+ L V ++T +Q+ LE + + R++L H E +
Sbjct: 2079 NLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQS 2138
Query: 480 FKLEN---------ERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTR 530
KL++ ERL+A+ E + + + Q L S+ + + + + M +
Sbjct: 2139 LKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQ 2198
Query: 531 LEADEVAAQLERCDKENKILKDEMNKE-IEAARRQFQSQLADLQQLPDILKITEAKLAEC 589
E ++ +R E ++ + + KE + + ++L + +++ E E
Sbjct: 2199 ASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGE--QGVQLGEVSGVEA 2256
Query: 590 QDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELER-- 647
+ G E+++ R R+EH + Q+ N QL ++++ER
Sbjct: 2257 EPSPDGMEKQS---------WRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERER 2307
Query: 648 ---KLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVE- 703
K EA A L++ + Q R ++ + Q E + A+ +E
Sbjct: 2308 RKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLER 2367
Query: 704 QTKEHALSKERAAQNKILDLETQLSRTKTELSQ 736
+ K+ +++ ++ L LS + ++Q
Sbjct: 2368 KQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQ 2400
Score = 70.1 bits (170), Expect = 8e-12
Identities = 144/755 (19%), Positives = 303/755 (40%), Gaps = 70/755 (9%)
Query: 56 VKTKNPPHCLEITPPSSEKLV---SVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGC 112
++T++P L P S +LV V+ L E+ + K+ + V
Sbjct: 1 METRSPG--LNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRK 58
Query: 113 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 172
L+++V + Q ++ LE + + + E + ++R E+ + E +
Sbjct: 59 LQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNT 118
Query: 173 KKHLQQEKECLMSKLVEAEMDGAAA----AKQVMALKDTIGKLKTE---KQMTCTDINTL 225
+ L EK +++K + +++ A+ + K++ +++ E + L
Sbjct: 119 QLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLL 178
Query: 226 TRQKELLLQKLSTFEETNRTLRDL--LREQHCKEDSERL-------MEQQGALLKRLAEA 276
+ +E++ + E + T RDL L+ +H + L + Q
Sbjct: 179 SLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRM 238
Query: 277 DSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKS-MESMRGHLQAQLRSKEAE 335
D + LLLL K +E+E+ E E Q K+ +L K+ ++ L A L + +
Sbjct: 239 DGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQ 298
Query: 336 NSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIR------------ 383
N IK L + + +ME L + +K SL++ I+
Sbjct: 299 NEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDN 358
Query: 384 -AQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLN 442
AQ E S E + Q +D +AL+ + S +R Q V+ DL ++
Sbjct: 359 IAQGSGHENSLELDSSIFSQFDYQD--ADKALTLVRSVLTRRRQAVQ---DLRQQLAGCQ 413
Query: 443 DRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAH 502
+ V +L+ QQ ++ E+ +L +RL + T E D L
Sbjct: 414 EAV-NLLQQQ---HDQWEEEGKALRQRLQKLTGE------------------RDTLAGQT 451
Query: 503 LEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAAR 562
+++Q S+ ++ + ++ + ++ A +L R + E ++ D + E +
Sbjct: 452 VDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQ 511
Query: 563 RQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLE 622
+ + + ++L ++L EAK +E +L R+ ++ + + +L R E
Sbjct: 512 EELHLAVRERERLQEMLMGLEAKQSESLSELITL-REALESSHLEGEL-LRQEQTEVTAA 569
Query: 623 MAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTR 682
+AR + ++ + + +LK + + L A + + + +A + ++Q L+LEE+ +
Sbjct: 570 LARAEQSIAELSSSENTLKTEVAD--LRAAAVKLSALNEALALDKVGLNQQLLQLEEENQ 627
Query: 683 ECGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRD 742
++ ++E+A E AR ++ A + A K LE QL + + ++L+
Sbjct: 628 ---SVCSRMEAA-EQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLR 683
Query: 743 DADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLK 777
D + + L + Q E+ ++ Q K
Sbjct: 684 DIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAK 718
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 117 bits (292), Expect = 6e-26
Identities = 142/668 (21%), Positives = 299/668 (44%), Gaps = 83/668 (12%)
Query: 113 LKSEVKMQKGERQMAKRFLEERK--------EELEEVAHELAETEHENTVLRHNIERMKE 164
++SE+ ++ E + R LEE + ++L+E + + + T L N+++ +
Sbjct: 160 MESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARR 219
Query: 165 EKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINT 224
EKD T+ + L ++ + L + + + A+ + T L KQ T
Sbjct: 220 EKDETMREFLELTEQSQKLQIQFQQLQ---ASETLRNSTHSSTAADLLQAKQQILTHQQQ 276
Query: 225 LTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLL 284
L Q LL E+ + D + ++ ++ E + K++ ++ E+
Sbjct: 277 LEEQDHLL-------EDYQKKKEDFTMQISFLQEKIKVYEMEQD--KKVENSNKEE---- 323
Query: 285 LLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIK 344
+Q+K+ +EEL +I E+ + + + + + G LQ Q+ K E + +++
Sbjct: 324 --IQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELT 381
Query: 345 NLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKE---------RAEKSEEY 395
N ++ Q E++ +M ++EL+++ +D + ++ ++ RAE E Y
Sbjct: 382 NSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMY 441
Query: 396 AEQLHVQLADKDLYVAEALSTLESWRSR-----------YNQVVKEKGDLELEIIVLND- 443
+Q+ VQ+ K + + ++ +E ++R Y+ + + ++L + +N+
Sbjct: 442 GQQI-VQM--KQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINEL 498
Query: 444 --RVTDLVNQQQTLEEKM---REDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKL 498
++ D +Q++ L+E++ E++ +L +L E S + + +R + + A E KL
Sbjct: 499 NIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKL 558
Query: 499 NQAHLE---VQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMN 555
N+AH V+ LKA + + ++ K +K E +LE +KE + D M
Sbjct: 559 NEAHKSLSTVEDLKAEIVSAS---ESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMA 615
Query: 556 KEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIE 615
+ EA + ++QL L E +L++ ++ L+ R NI+ + + +
Sbjct: 616 ESQEAELERLRTQL---------LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQ 666
Query: 616 HQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREE---AIHQ 672
G + EM+ +K + Q E L K ++L LE + ++++ V +K EE I++
Sbjct: 667 IDGLQNEMS-QKIETMQFEKDNLITKQNQL--ILEISKLKDLQQSLVNSKSEEMTLQINE 723
Query: 673 SQLRLE---EKTRECGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLETQLSR 729
Q +E ++ +E GT LE +++ + + E ++ KE Q K LE + S
Sbjct: 724 LQKEIEILRQEEKEKGT----LEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSI 779
Query: 730 TKTELSQL 737
K E L
Sbjct: 780 LKDEKKTL 787
Score = 94.0 bits (232), Expect = 5e-19
Identities = 136/691 (19%), Positives = 293/691 (42%), Gaps = 101/691 (14%)
Query: 124 RQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECL 183
++ +R ++ER EE+E++ + E E V +++++ K F ++ K E
Sbjct: 2132 KEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK-----PELS 2186
Query: 184 MSKLVEAEMDGA-AAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEET 242
+ ++AE D K++ L++ + + + E + ++ L Q E +QK +E+
Sbjct: 2187 LEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLE--IQK----KES 2240
Query: 243 NRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLL-----LLQDKDKEVEEL 297
L++L +E +D ME+ G +K ++ +L ++Q+K+ E+++L
Sbjct: 2241 TTRLQELEQENKLFKDD---MEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQL 2297
Query: 298 LQEIQCEKAQAK--TASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKA 355
+++ + Q K T +++ + + L+ Q+ ++ C++ +N E Q
Sbjct: 2298 NEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQE--CVK-RNREEEIEQLNE 2354
Query: 356 EVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEK--SEEYAEQLHVQLADKDLYVAEA 413
+E + ++L + QK + SL + + K + + +E+ A + V+ A++++ +
Sbjct: 2355 VIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMK- 2413
Query: 414 LSTLESWRSRYNQVVKE------------------------------KGDLELEIIVLND 443
+ L+ + NQ+ +E K ELE+++ D
Sbjct: 2414 -NVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTED 2472
Query: 444 RVTDLVNQQ--QTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQA 501
+ L NQ ++ EE + +L RL + + SA LE L + ++D Q
Sbjct: 2473 ALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLE---LTQCYKQIKDMQEQG 2529
Query: 502 HLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAA 561
E + L+ + N + +++ + + ++++ + V + C I + E E
Sbjct: 2530 QFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTI-----SSEPERT 2584
Query: 562 RRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKL 621
Q +QL + + DI LT IS+L S++ L
Sbjct: 2585 NIQNLNQLREDELGSDISA----------------------LTLRISELESQVVEMHTSL 2622
Query: 622 EMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKT 681
+ +E+ + ++K + K+ EL++ LE + E + + ++ + ++ L
Sbjct: 2623 ILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSN 2682
Query: 682 RECGTLARQLESAIEDARRQVEQTK-EHALSKERA--AQNKILDLETQLSRTKTELSQLR 738
E G + +E R + TK E A KE+A Q ++L ET ++ + +LSQ+R
Sbjct: 2683 EESGFF-----NELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVR 2737
Query: 739 RSRDDADRRYQSRLQDLKDRLEQSESTNRSM 769
+A + + + +D E ES M
Sbjct: 2738 DHLAEAKEKLS--ILEKEDETEVQESKKACM 2766
Score = 86.3 bits (212), Expect = 1e-16
Identities = 144/703 (20%), Positives = 291/703 (41%), Gaps = 106/703 (15%)
Query: 123 ERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQK--------- 173
E+ + +R ++E+ + ++ + EL + L ++++EE++ QK
Sbjct: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGP 1989
Query: 174 --KHLQQEKECLMSKLVEAEMDGAAA----AKQVMALKDTIG-------KLKTEKQMTCT 220
+ L QE E LM + +E + KQV AL+ + +L+ EK
Sbjct: 1990 VEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELM 2049
Query: 221 DINTLTRQKELLLQKLSTF-------------------EETNRTLRDLLREQHCKEDSER 261
D+ + E L+K+ F ++ + L+ + R Q E R
Sbjct: 2050 DLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTR 2109
Query: 262 LMEQQGALLKRLAEADSE----KARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKS 317
+EQ LK + SE K +L +Q++++E+E+L ++ E QA S +
Sbjct: 2110 EVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR-ELEQALLVSADTFQ 2168
Query: 318 MESMRGH-----------LQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKE 366
R H L+ QL+++ R +I NLE Q + E+E E++++
Sbjct: 2169 KVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQ 2228
Query: 367 LKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLES--WRSRY 424
L + + K+ ++ ++ + ++ E+L + + + D A+ST + ++
Sbjct: 2229 LHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESD-----AMSTQDQHVLFGKF 2283
Query: 425 NQVVKEKGDLELEIIVLNDRVTDLVNQQQ-TLEEKMREDRDSLVERLHRQTAEYSAFKLE 483
Q+++EK E+EI LN++VT L Q + T + K+ E+++ L+ L Q +
Sbjct: 2284 AQIIQEK---EVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQ---IECLMSD 2337
Query: 484 NERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERC 543
E +K + ++LN+ ++QQ A++ M + S+ EAD + QL
Sbjct: 2338 QECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE------EADSLKHQL--- 2388
Query: 544 DKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDL 603
D + E A +Q ++ ++ + ++LK T K+ + +L +R+ +
Sbjct: 2389 --------DVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESV 2440
Query: 604 TAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVI 663
I S + + D LS ELE L + +++E
Sbjct: 2441 EKIQSIPENSVNVAID-----------------HLSKDKPELEVVLTEDALKSLENQTYF 2483
Query: 664 AKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDL 723
EE S + LE + + + + + +Q++ +E + Q KI++L
Sbjct: 2484 KSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNL 2543
Query: 724 ETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTN 766
+ ++ K + + + + +A + Y QD + + E TN
Sbjct: 2544 Q-KIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTN 2585
Score = 84.0 bits (206), Expect = 5e-16
Identities = 131/705 (18%), Positives = 287/705 (40%), Gaps = 81/705 (11%)
Query: 95 KMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEV---AHELAETEHE 151
K+ DK + L + E+K K E +K+ + EE++++ EL + H+
Sbjct: 351 KLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHK 410
Query: 152 NTVLRHNI-ERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGK 210
++ +I +RM++E T + + L+ E + + + + +M + + +++ +
Sbjct: 411 DSQFETDIVQRMEQE---TQRKLEQLRAELDEMYGQQI-VQMKQELIRQHMAQMEEMKTR 466
Query: 211 LKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALL 270
K E + + +T ++ + E N L+D E+L E+ G +L
Sbjct: 467 HKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQD------TNSQKEKLKEELGLIL 520
Query: 271 KRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLR 330
+ EK L +++E+L++E+ + Q + A + ES L
Sbjct: 521 E-------EKCAL-------QRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLS 566
Query: 331 SKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAE 390
+ E + + ++ + +H+AEV +L+ L+++ + + + ++ A+ ER
Sbjct: 567 TVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLR 626
Query: 391 KSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVN 450
++ + + +DL + ++ + K K +L + ++ L N
Sbjct: 627 TQLLFSHEEELSKLKEDLEIEHRIN-----------IEKLKDNLGIH---YKQQIDGLQN 672
Query: 451 QQQTLEEKMREDRDSLVERLHRQTAEYSAFK-LENERLKASFAPMEDKLNQAHLEVQQLK 509
+ E M+ ++D+L+ + ++ E S K L+ + + M ++N+ E++ L+
Sbjct: 673 EMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILR 732
Query: 510 ASVKNYEGMIDNYKSQVMKTRL-------EADEVAAQLERCDKENKILKDEMNKEIEAAR 562
K + + +KT L + +++ + + + EN ILKDE + +
Sbjct: 733 QEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLK 792
Query: 563 RQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLE 622
+ D +K +++K + + +++ +N DL L IE Q +
Sbjct: 793 IHTPVSQEERLIFLDSIK-SKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFS 851
Query: 623 MAREKHQASQKENKQ---LSLKV-DELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLE 678
A + + + +E ++ LKV D+LE ++ + Q +E+ + E +H ++
Sbjct: 852 FAEKNFEVNYQELQEEYACLLKVKDDLE---DSKNKQELEYKSKLKALNEELHLQRIN-- 906
Query: 679 EKTRECGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLR 738
T + S ++ + V +T E E+ + LE R K ELSQ
Sbjct: 907 ------PTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEV-TKREKLELSQ-- 957
Query: 739 RSRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSSYANV 783
RL DL ++L+Q + V+ LK V
Sbjct: 958 ------------RLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQV 990
Score = 82.4 bits (202), Expect = 2e-15
Identities = 121/635 (19%), Positives = 287/635 (45%), Gaps = 79/635 (12%)
Query: 160 ERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTC 219
E++KEE + +K LQ++ E L+ +L + + +Q+ + TI + +++
Sbjct: 510 EKLKEELGLILEEKCALQRQLEDLVEEL-------SFSREQIQRARQTIAEQESKLNEAH 562
Query: 220 TDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAE---A 276
++T+ K ++ + +E L+ + K E L +++ A+L R+AE A
Sbjct: 563 KSLSTVEDLKAEIVSASESRKELE--LKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEA 620
Query: 277 DSEKARLLLLLQDKD-----KEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRS 331
+ E+ R LL ++ KE E+ I EK + + ++ ++ + ++ +
Sbjct: 621 ELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIET 680
Query: 332 KEAENSRLCMQ----------IKNLERSGNQHKAE-----VEAIMEQLKELKQKGDRDKE 376
+ E L + +K+L++S K+E + + ++++ L+Q+ +++K
Sbjct: 681 MQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQE-EKEKG 739
Query: 377 SLKKAIRA--------QKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVV 428
+L++ ++ +K+ EK + E+ QL ++ + + TLE + V
Sbjct: 740 TLEQEVQELQLKTELLEKQMKEKENDLQEKF-AQLEAENSILKDEKKTLEDMLKIHTPVS 798
Query: 429 KEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLK 488
+E+ + L+ I + D V +++ E + E+ + L ++ + E +E +R
Sbjct: 799 QEERLIFLDSI--KSKSKDSVWEKEI--EILIEENEDLKQQCIQLNEE-----IEKQRNT 849
Query: 489 ASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVM--KTRLEADEVAAQLERCDKE 546
SFA ++N L+ ++ +K + + D+ Q + K++L+A L+R +
Sbjct: 850 FSFAEKNFEVNYQELQ-EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPT 908
Query: 547 NKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAI 606
+K + F + + ++ ++ E E ++L+ +R+ ++L+
Sbjct: 909 TVKMKSSV----------FDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQR 958
Query: 607 ISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEF--LQVIA 664
+SDL +++ + ++ E+ ++ ++E +Q+SL+ ELE + A+N++ QV +
Sbjct: 959 LSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSS 1018
Query: 665 KREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQT---KEHALSKERAAQNKIL 721
+ + + E G++++ +S E+++ VE + + +E + IL
Sbjct: 1019 LLDGVVTMTSRGAE------GSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLIL 1072
Query: 722 DLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLK 756
D + T+ S LR ++ + + Q L LK
Sbjct: 1073 DHLPSV----TKESSLRATQPSENDKLQKELNVLK 1103
Score = 73.6 bits (179), Expect = 7e-13
Identities = 117/598 (19%), Positives = 251/598 (41%), Gaps = 74/598 (12%)
Query: 230 ELLLQKLSTFEETNRTLRDLLREQ-HCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQ 288
E + + S E T +L+RE K+++ ++ Q L +RL E + +L + L
Sbjct: 1859 EAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELS 1918
Query: 289 DKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLER 348
+ ++ E + Q + +++ +E +L+ EAE ++ + + L R
Sbjct: 1919 KAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSR 1978
Query: 349 SGNQHKAEVEAIMEQL-----KELKQK------GDRDKESLKKAIRA----QKERAEKSE 393
KAE + +QL K +K+K ++ ++ L+K ++A +E+ +
Sbjct: 1979 QKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFI 2038
Query: 394 EYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKG-DLELEIIVLNDRVTDLVNQQ 452
E ++ + +L D + + LE + + + E+ D E E V + L Q
Sbjct: 2039 ELEQEKNTELMD----LRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL 2094
Query: 453 ------QTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQ 506
Q + E + + L L +T + S L E+L+ +++ + V+
Sbjct: 2095 KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR 2154
Query: 507 QLK----ASVKNYEGMIDNYKSQVMKTRLEAD-EVAAQLER--CDKENKILKDEMNKEIE 559
+L+ S ++ + D ++ + E EV Q ER D++ K + + + +++E
Sbjct: 2155 ELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITN-LEEQLE 2213
Query: 560 AARRQFQSQLADLQQLPDILKI------TEAKLAECQDQLQGYERKNIDLTAIISDLRSR 613
R + +++ ++QQL L+I T + E +++L + + + L SD S
Sbjct: 2214 QFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMST 2273
Query: 614 IEHQ---GDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAI 670
+ G ++ +EK + E QL+ +V +L+++L+ T+ +VI ++ E I
Sbjct: 2274 QDQHVLFGKFAQIIQEK----EVEIDQLNEQVTKLQQQLKITTDN-----KVIEEKNELI 2324
Query: 671 HQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKE-------------HALSKERAAQ 717
+ ++E + + R E IE +E+ ++ H+LS+E +
Sbjct: 2325 RDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSL 2384
Query: 718 NKILD--------LETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNR 767
LD LE Q+ E++ ++ + + + Q+L + ES +
Sbjct: 2385 KHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEK 2442
Score = 71.2 bits (173), Expect = 3e-12
Identities = 106/556 (19%), Positives = 230/556 (41%), Gaps = 86/556 (15%)
Query: 213 TEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKR 272
TE + + +++ + E L++ + T +L+DL+ + + ++E Q
Sbjct: 2961 TESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSH---- 3016
Query: 273 LAEADSE-KARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRS 331
E+ S+ + LLL LQ E +L + A ++ + + +Q Q
Sbjct: 3017 --ESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQ--G 3072
Query: 332 KEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEK 391
E + + C+Q KA+ +++ +++ L + + K +LK+ ++K E
Sbjct: 3073 VEYQAAMECLQ-----------KADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQEL 3121
Query: 392 SEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQ 451
E +Q Q+ + + L S + R ++ ++ L E +V+ + ++L
Sbjct: 3122 LEYNIQQKQSQMLEMQV-------ELSSMKDRATELQEQ---LSSEKMVVAELKSELAQT 3171
Query: 452 QQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKAS 511
+ LE ++ H+ E AF+LE ++DK ++ HL L +
Sbjct: 3172 KLELETTLKAQ--------HKHLKELEAFRLE----------VKDKTDEVHLLNDTLASE 3213
Query: 512 VKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLAD 571
K KS+ ++ LE ++ A+L R ++ +K +++ +E+ +++
Sbjct: 3214 QK---------KSRELQWALEKEK--AKLGRSEERDKEELEDLKFSLESQKQRNLQLNLL 3262
Query: 572 LQQLPDILKITEAKLAECQ----DQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREK 627
L+Q +L ++ K+ + QL + +N++L ++ + RI L+ RE
Sbjct: 3263 LEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL 3322
Query: 628 HQASQKEN-------------------KQLSLKVDELERKLEATSAQNIEFLQVIAKREE 668
H Q + KQL K + L T ++ LQ + E+
Sbjct: 3323 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEK 3382
Query: 669 --AIHQSQLRLEEKTRECGTLA-RQLESAIEDARRQVEQTKEHALSKERAAQNKILDLET 725
+H+ L+ E++ G +L+S +ED +RQ+E+ ++ + Q ++ +
Sbjct: 3383 DRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQ-RLQGIMQ 3441
Query: 726 QLSRTKTELSQLRRSR 741
+ + + E + R SR
Sbjct: 3442 EFQKQELEREEKRESR 3457
Score = 69.7 bits (169), Expect = 1e-11
Identities = 167/780 (21%), Positives = 320/780 (41%), Gaps = 138/780 (17%)
Query: 99 YDKKIDSLMNAVG------CLKSEVKMQKGE----RQMAKRFLEERKEELEEVAHELAET 148
+ KKI L+ AV +E GE +Q+++ +LEERK + ++
Sbjct: 2939 FPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTIS------ 2992
Query: 149 EHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSK----LVEAEMDGAAAAKQVMAL 204
++ + + ++R E D + + E L++ L E + AA ++ AL
Sbjct: 2993 SLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTAL 3052
Query: 205 --KDTIGKLKTEKQ---------MTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQ 253
D +G L +Q + ++ LL + + + N L REQ
Sbjct: 3053 GTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQ 3112
Query: 254 HCKEDSERLME-----QQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQA 308
++ S+ L+E +Q +L+ E S K R L + E + ++ E++ E AQ
Sbjct: 3113 ESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSE-KMVVAELKSELAQT 3171
Query: 309 KTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLE--------RSGNQHKAEVEAI 360
K EL ++++ HL KE E RL ++ K E S + E++
Sbjct: 3172 KL--ELETTLKAQHKHL------KELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWA 3223
Query: 361 MEQLK-ELKQKGDRDKESL---KKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALST 416
+E+ K +L + +RDKE L K ++ +QK+R QL++ L + + E+
Sbjct: 3224 LEKEKAKLGRSEERDKEELEDLKFSLESQKQRNL-------QLNLLLEQQKQLLNESQQK 3276
Query: 417 LESWRSRYN-QVVKEKG-DLELEIIVLN------------DRVTDLVNQQQTLE------ 456
+ES R Y+ Q+ +E+G +LEL++++ + DR +L Q Q+ +
Sbjct: 3277 IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSR 3336
Query: 457 ------------EKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLE 504
+K E++ S + L +T +Y L+ + + K Q E
Sbjct: 3337 PPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQE 3396
Query: 505 --------VQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNK 556
+ +L++ V++ + ++ + QV K LE + ++ K+ L+ E +
Sbjct: 3397 ANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQE--LEREEKR 3454
Query: 557 EIEAARRQFQSQLADLQQLPDILKITEAKLAE--CQDQLQGYERKNIDLTAIISDLRSRI 614
E +RR L + P +T + Q +++G E K + +I ++
Sbjct: 3455 E---SRRILYQNLNE----PTTWSLTSDRTRNWVLQQKIEG-ETKESNYAKLI-EMNGGG 3505
Query: 615 EHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQ 674
+LEM R+K Q + + L K E +L+ +A + +F+ V +E I Q Q
Sbjct: 3506 TGCNHELEMIRQKLQCVASKLQVLPQKASE---RLQFETADDEDFIWVQENIDEIILQLQ 3562
Query: 675 LRLEEKTRE---------CGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLET 725
++ E CG+L +L + + Q E ++ +N ++ LE
Sbjct: 3563 KLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTE----EKNDLRNMVMKLEE 3618
Query: 726 QLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRL-EQSESTNRSMQNYVQFLKSSYANVF 784
Q+ + Q RD++ R + +++ + + E NR + LK + A V+
Sbjct: 3619 QIRWYR----QTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVY 3674
Score = 47.8 bits (112), Expect = 4e-05
Identities = 147/788 (18%), Positives = 314/788 (39%), Gaps = 156/788 (19%)
Query: 76 VSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERK 135
+ V S LS+ D + + ++++ L + + L+ ++K + + L++R
Sbjct: 1317 IDVNHKSKLSSLQD----LEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRL 1372
Query: 136 EELEE--------------VAHELAETEHENTVLRHNIER---------MKEEKDFTILQ 172
+ + E + T + + ++ NI+ +KEE + L
Sbjct: 1373 QAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLL 1432
Query: 173 KKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELL 232
+K Q++ E ++K++ + A A+Q + + GK T ++Q +
Sbjct: 1433 EKQYQEQLEEEVAKVIVSM--SIAFAQQTELSRISGGKENTAS----------SKQAHAV 1480
Query: 233 LQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDK 292
Q+ + + +D + Q + + E+ L K L E E +LL + D
Sbjct: 1481 CQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKE-----ILLSNSDP 1535
Query: 293 E------------VEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLC 340
EE+ + + + E+S S SM Q L ++ E+ R
Sbjct: 1536 HDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVS--SMDASRQLMLNEEQLEDMR-- 1591
Query: 341 MQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLH 400
+ ++ Q +E +Q + +++ + + Q+E E+ +E ++L+
Sbjct: 1592 -----------------QELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLN 1634
Query: 401 VQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMR 460
QLA + E L + R +++E L+ + +++ + T +
Sbjct: 1635 RQLAQRSSIDNENLVS-----ERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGN 1689
Query: 461 EDRDSLVER------LHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASV-- 512
E++ + E+ L R+ + L NER A ++L + LEV + A+V
Sbjct: 1690 ENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKA--NNRLLKILLEVVKTTAAVEE 1747
Query: 513 ---KNYEGMID-NYKSQVMKTRLEADEVAAQLERC-DKENKILKDE-------------- 553
++ G++D + KSQ + + E A ++ C +E+ + DE
Sbjct: 1748 TIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRND 1807
Query: 554 -------MNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAI 606
+ E ++R +S A + P+ E + +LQ K L
Sbjct: 1808 INMWSKVTEEGTELSQRLVRSGFAGTEIDPE----NEELMLNISSRLQAAVEK---LLEA 1860
Query: 607 ISDLRSRIEH-QGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAK 665
IS+ S++EH + + E+ RE + Q+ + L + +EL +L S + ++K
Sbjct: 1861 ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ-EELRERLHEESRAREQLAVELSK 1919
Query: 666 REEAIH-------QSQLRLEEKTRECGTLARQLESA------IEDARRQVEQTKEHALSK 712
E I + +++EKT L ++L A +E ++Q+++ +E LS+
Sbjct: 1920 AEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERE-LLSR 1978
Query: 713 ERAA--------QNKILDLETQLSRTKTELS-QLRRSRDDADRRYQSRLQDLKDR----- 758
++ A + ++L +L + K E+ Q + RDD ++ ++ D++++
Sbjct: 1979 QKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFI 2038
Query: 759 -LEQSEST 765
LEQ ++T
Sbjct: 2039 ELEQEKNT 2046
Score = 44.3 bits (103), Expect = 5e-04
Identities = 113/584 (19%), Positives = 219/584 (37%), Gaps = 91/584 (15%)
Query: 113 LKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQ 172
L ++K + GE ++ K+E E+V+ E E ++ HN + D Q
Sbjct: 962 LSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELE---IIINHNRAENVQSCD---TQ 1015
Query: 173 KKHLQQEKECLMSKLVE---AEMDGAAAAKQVMALKD-------TIGKLKTEKQMTCTDI 222
L + S+ E ++++ + + + ++D T+G+ ++Q+ +
Sbjct: 1016 VSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHL 1075
Query: 223 NTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKAR 282
++T++ L + S ++ + L L EQ+ D ME Q L + ++ R
Sbjct: 1076 PSVTKESSLRATQPSENDKLQKELNVLKSEQN---DLRLQMEAQRICLSLVYSTHVDQVR 1132
Query: 283 LLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQ 342
+ +KDK + L +E+ AQ + EL K
Sbjct: 1133 -EYMENEKDKALCSLKEELIF--AQEEKIKELQKI------------------------- 1164
Query: 343 IKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQ 402
H+ E++ + Q + GD K + QK +E+ + + L
Sbjct: 1165 ----------HQLELQTMKTQ-----ETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSV 1209
Query: 403 LADKDLYVAEALSTLESWRSRYN--QVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMR 460
L + Y AL + + N + E D EL+ V D TL K+
Sbjct: 1210 LGE---YYTPALKCEVNAEDKENSGDYISENEDPELQ--DYRYEVQDFQENMHTLLNKVT 1264
Query: 461 EDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMID 520
E+ + L L QT + + + +K F E+ L + E + + + N E +
Sbjct: 1265 EEYNKL---LVLQTRLSKIWGQQTDGMKLEFG--EENLPKEETEFLSIHSQMTNLEDIDV 1319
Query: 521 NYKSQVM------KTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQ 574
N+KS++ KT+LE + + ++ + E N E E Q + Q
Sbjct: 1320 NHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSEST 1379
Query: 575 LPDILKITEAKLAECQDQLQGYE----RKNIDLTAIISDLRSRIEHQGDKLEMAREKHQA 630
+P L + + E Q Y +KNID T S ++ + + +++ +++Q
Sbjct: 1380 VPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSG-EFGVKEETNIVKLLEKQYQ- 1437
Query: 631 SQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQ 674
+QL +V ++ + AQ E ++ +E Q
Sbjct: 1438 -----EQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQ 1476
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.125 0.328
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,053,674
Number of Sequences: 37866
Number of extensions: 1108281
Number of successful extensions: 18789
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 482
Number of HSP's successfully gapped in prelim test: 1131
Number of HSP's that attempted gapping in prelim test: 6453
Number of HSP's gapped (non-prelim): 6152
length of query: 805
length of database: 18,247,518
effective HSP length: 110
effective length of query: 695
effective length of database: 14,082,258
effective search space: 9787169310
effective search space used: 9787169310
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.