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Search of human proteins with 239756427
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent
protein kinase-1 [Homo sapiens]
(471 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent ... 961 0.0
gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform... 740 0.0
gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo ... 704 0.0
gi|47680169 3-phosphoinositide dependent protein kinase-1 isofor... 289 4e-78
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 216 3e-56
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 216 3e-56
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 216 3e-56
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 216 3e-56
gi|4826948 protein kinase, X-linked [Homo sapiens] 212 5e-55
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 211 1e-54
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 211 1e-54
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 207 1e-53
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 207 1e-53
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 204 1e-52
gi|4502023 AKT2 kinase [Homo sapiens] 203 2e-52
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 202 5e-52
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 200 2e-51
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 198 1e-50
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 198 1e-50
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 198 1e-50
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 198 1e-50
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 197 1e-50
gi|62241015 AKT1 kinase [Homo sapiens] 197 2e-50
gi|62241013 AKT1 kinase [Homo sapiens] 197 2e-50
gi|62241011 AKT1 kinase [Homo sapiens] 197 2e-50
gi|4506067 protein kinase C, alpha [Homo sapiens] 195 9e-50
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 195 9e-50
gi|28557781 protein kinase C, eta [Homo sapiens] 193 2e-49
gi|4885563 protein kinase C, epsilon [Homo sapiens] 192 4e-49
gi|5453976 protein kinase C, theta [Homo sapiens] 192 4e-49
>gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent
protein kinase-1 [Homo sapiens]
Length = 471
Score = 961 bits (2483), Expect = 0.0
Identities = 471/471 (100%), Positives = 471/471 (100%)
Query: 1 MARAGLRRGGRQLTADRGAQLACPVLGYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGI 60
MARAGLRRGGRQLTADRGAQLACPVLGYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGI
Sbjct: 1 MARAGLRRGGRQLTADRGAQLACPVLGYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGI 60
Query: 61 PGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARE 120
PGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARE
Sbjct: 61 PGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARE 120
Query: 121 LATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQTTRRLYFGLSY 180
LATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQTTRRLYFGLSY
Sbjct: 121 LATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQTTRRLYFGLSY 180
Query: 181 AKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQI 240
AKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQI
Sbjct: 181 AKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQI 240
Query: 241 TDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPP 300
TDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPP
Sbjct: 241 TDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPP 300
Query: 301 FRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPF 360
FRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPF
Sbjct: 301 FRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPF 360
Query: 361 FESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNGAARTGRRAPPALAPGSHVRGLLPGL 420
FESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNGAARTGRRAPPALAPGSHVRGLLPGL
Sbjct: 361 FESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNGAARTGRRAPPALAPGSHVRGLLPGL 420
Query: 421 SHLRLAWCLYNCAAKMLQNTACLSTETPECCVLELLGRGVGGDTGTFFSAE 471
SHLRLAWCLYNCAAKMLQNTACLSTETPECCVLELLGRGVGGDTGTFFSAE
Sbjct: 421 SHLRLAWCLYNCAAKMLQNTACLSTETPECCVLELLGRGVGGDTGTFFSAE 471
>gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform 1
[Homo sapiens]
Length = 556
Score = 740 bits (1911), Expect = 0.0
Identities = 363/367 (98%), Positives = 364/367 (99%)
Query: 28 YDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHA 87
YDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHA
Sbjct: 9 YDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHA 68
Query: 88 QPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVT 147
QPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVT
Sbjct: 69 QPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVT 128
Query: 148 RERDVMSRLDHPFFVKLYFTFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAE 207
RERDVMSRLDHPFFVKLYFTFQ +LYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAE
Sbjct: 129 RERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAE 188
Query: 208 IVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQY 267
IVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQY
Sbjct: 189 IVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQY 248
Query: 268 VSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPK 327
VSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPK
Sbjct: 249 VSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPK 308
Query: 328 ARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSED 387
ARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSED
Sbjct: 309 ARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSED 368
Query: 388 DEDCYGN 394
DEDCYGN
Sbjct: 369 DEDCYGN 375
>gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo
sapiens]
Length = 396
Score = 704 bits (1817), Expect = 0.0
Identities = 351/371 (94%), Positives = 353/371 (95%), Gaps = 3/371 (0%)
Query: 47 MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 106
MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI
Sbjct: 1 MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 60
Query: 107 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF 166
LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF
Sbjct: 61 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF 120
Query: 167 TFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK 226
TFQ +LYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK
Sbjct: 121 TFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK 180
Query: 227 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA 286
PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA
Sbjct: 181 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA 240
Query: 287 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC 346
LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC
Sbjct: 241 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC 300
Query: 347 EEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNGAARTGRRAPPA 406
EEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGN + R A
Sbjct: 301 EEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNVSWPGWRARQVA 360
Query: 407 LAP---GSHVR 414
L P G H R
Sbjct: 361 LGPPCTGLHAR 371
>gi|47680169 3-phosphoinositide dependent protein kinase-1 isoform 2
[Homo sapiens]
Length = 429
Score = 289 bits (739), Expect = 4e-78
Identities = 138/138 (100%), Positives = 138/138 (100%)
Query: 257 RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL 316
RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL
Sbjct: 111 RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL 170
Query: 317 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPK 376
EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPK
Sbjct: 171 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPK 230
Query: 377 LTAYLPAMSEDDEDCYGN 394
LTAYLPAMSEDDEDCYGN
Sbjct: 231 LTAYLPAMSEDDEDCYGN 248
Score = 208 bits (530), Expect = 7e-54
Identities = 101/103 (98%), Positives = 102/103 (99%)
Query: 28 YDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHA 87
YDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHA
Sbjct: 9 YDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHA 68
Query: 88 QPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIK 130
QPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYA +
Sbjct: 69 QPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYATR 111
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 216 bits (551), Expect = 3e-56
Identities = 120/313 (38%), Positives = 180/313 (57%), Gaps = 8/313 (2%)
Query: 66 QGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSR 125
Q P + P P + P P K P DF F K++G+GSF V+LAR A
Sbjct: 64 QEPELMNANPSPPPSPSQQINLGPSSNPHAK-PSDFHFLKVIGKGSFGKVLLARHKAEEV 122
Query: 126 EYAIKILEKRHIIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQTTRRLYFGLSYAKNG 184
YA+K+L+K+ I+K+ + ++ ER+V+ + + HPF V L+F+FQT +LYF L Y G
Sbjct: 123 FYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGG 182
Query: 185 ELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG 244
EL ++++ F E RFY AEI SAL YLH I++RDLKPENILL+ HI +TDFG
Sbjct: 183 ELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG 242
Query: 245 TAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAG 304
K + ++F GT +Y++PE+L ++ ++ D W LG ++Y+++ GLPPF +
Sbjct: 243 LCK--ENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR 300
Query: 305 NEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESV 364
N ++ I+ AR L+E LL D TKRLG + + + +K+H FF +
Sbjct: 301 NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAK--DDFMEIKSHVFFSLI 358
Query: 365 TWENLHQQ--TPP 375
W++L + TPP
Sbjct: 359 NWDDLINKKITPP 371
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 216 bits (551), Expect = 3e-56
Identities = 120/313 (38%), Positives = 180/313 (57%), Gaps = 8/313 (2%)
Query: 66 QGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSR 125
Q P + P P + P P K P DF F K++G+GSF V+LAR A
Sbjct: 78 QEPELMNANPSPPPSPSQQINLGPSSNPHAK-PSDFHFLKVIGKGSFGKVLLARHKAEEV 136
Query: 126 EYAIKILEKRHIIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQTTRRLYFGLSYAKNG 184
YA+K+L+K+ I+K+ + ++ ER+V+ + + HPF V L+F+FQT +LYF L Y G
Sbjct: 137 FYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGG 196
Query: 185 ELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG 244
EL ++++ F E RFY AEI SAL YLH I++RDLKPENILL+ HI +TDFG
Sbjct: 197 ELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG 256
Query: 245 TAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAG 304
K + ++F GT +Y++PE+L ++ ++ D W LG ++Y+++ GLPPF +
Sbjct: 257 LCK--ENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR 314
Query: 305 NEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESV 364
N ++ I+ AR L+E LL D TKRLG + + + +K+H FF +
Sbjct: 315 NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAK--DDFMEIKSHVFFSLI 372
Query: 365 TWENLHQQ--TPP 375
W++L + TPP
Sbjct: 373 NWDDLINKKITPP 385
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 216 bits (551), Expect = 3e-56
Identities = 120/313 (38%), Positives = 180/313 (57%), Gaps = 8/313 (2%)
Query: 66 QGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSR 125
Q P + P P + P P K P DF F K++G+GSF V+LAR A
Sbjct: 92 QEPELMNANPSPPPSPSQQINLGPSSNPHAK-PSDFHFLKVIGKGSFGKVLLARHKAEEV 150
Query: 126 EYAIKILEKRHIIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQTTRRLYFGLSYAKNG 184
YA+K+L+K+ I+K+ + ++ ER+V+ + + HPF V L+F+FQT +LYF L Y G
Sbjct: 151 FYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGG 210
Query: 185 ELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG 244
EL ++++ F E RFY AEI SAL YLH I++RDLKPENILL+ HI +TDFG
Sbjct: 211 ELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG 270
Query: 245 TAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAG 304
K + ++F GT +Y++PE+L ++ ++ D W LG ++Y+++ GLPPF +
Sbjct: 271 LCK--ENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR 328
Query: 305 NEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESV 364
N ++ I+ AR L+E LL D TKRLG + + + +K+H FF +
Sbjct: 329 NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAK--DDFMEIKSHVFFSLI 386
Query: 365 TWENLHQQ--TPP 375
W++L + TPP
Sbjct: 387 NWDDLINKKITPP 399
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 216 bits (551), Expect = 3e-56
Identities = 120/313 (38%), Positives = 180/313 (57%), Gaps = 8/313 (2%)
Query: 66 QGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSR 125
Q P + P P + P P K P DF F K++G+GSF V+LAR A
Sbjct: 159 QEPELMNANPSPPPSPSQQINLGPSSNPHAK-PSDFHFLKVIGKGSFGKVLLARHKAEEV 217
Query: 126 EYAIKILEKRHIIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQTTRRLYFGLSYAKNG 184
YA+K+L+K+ I+K+ + ++ ER+V+ + + HPF V L+F+FQT +LYF L Y G
Sbjct: 218 FYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGG 277
Query: 185 ELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG 244
EL ++++ F E RFY AEI SAL YLH I++RDLKPENILL+ HI +TDFG
Sbjct: 278 ELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG 337
Query: 245 TAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAG 304
K + ++F GT +Y++PE+L ++ ++ D W LG ++Y+++ GLPPF +
Sbjct: 338 LCK--ENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR 395
Query: 305 NEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESV 364
N ++ I+ AR L+E LL D TKRLG + + + +K+H FF +
Sbjct: 396 NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAK--DDFMEIKSHVFFSLI 453
Query: 365 TWENLHQQ--TPP 375
W++L + TPP
Sbjct: 454 NWDDLINKKITPP 466
>gi|4826948 protein kinase, X-linked [Homo sapiens]
Length = 358
Score = 212 bits (540), Expect = 5e-55
Identities = 110/282 (39%), Positives = 168/282 (59%), Gaps = 6/282 (2%)
Query: 91 PQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRER 150
P+P +DF +G G+F V L +E +A+K++ +I+ + +V E+
Sbjct: 39 PEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEK 98
Query: 151 DVMSRLDHPFFVKLYFTFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVS 210
V+ + HPF ++L++T+ R LY + Y GEL Y+R G F T FY+AEI+
Sbjct: 99 SVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIIC 158
Query: 211 ALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSP 270
A+EYLH K I++RDLKPENILL+ D HI++TDFG AK L R + GT +Y++P
Sbjct: 159 AIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVD-----RTWTLCGTPEYLAP 213
Query: 271 ELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARD 330
E++ K ++ D WALG +I+++++G PPF N + I+QKI+ + DFP +D
Sbjct: 214 EVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKD 273
Query: 331 LVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 372
L++KLLV+D T+RLG G +K H +F SV WE + Q+
Sbjct: 274 LIKKLLVVDRTRRLG-NMKNGANDVKHHRWFRSVDWEAVPQR 314
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 211 bits (536), Expect = 1e-54
Identities = 105/274 (38%), Positives = 163/274 (59%), Gaps = 6/274 (2%)
Query: 99 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 158
EDF+ K LG GSF V+L + AT + YA+KIL+K+ ++K ++ + E+ ++ ++
Sbjct: 42 EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101
Query: 159 PFFVKLYFTFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 218
PF V+L + F+ LY + Y GE+ ++R+IG F E RFY A+IV EYLH
Sbjct: 102 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161
Query: 219 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSA 278
+I+RDLKPEN+L++ +IQ+TDFG AK + + R + GT +Y++PE++ K
Sbjct: 162 DLIYRDLKPENLLIDHQGYIQVTDFGFAKRV-----KGRTWTLCGTPEYLAPEIILSKGY 216
Query: 279 CKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 338
K+ D WALG +IY++ AG PPF A I++KI+ + FP F +DL+ LL +
Sbjct: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 276
Query: 339 DATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 372
D TKR G G +K H +F + W ++Q+
Sbjct: 277 DLTKRFG-NLKNGVSDIKTHKWFATTDWIAIYQR 309
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 211 bits (536), Expect = 1e-54
Identities = 105/274 (38%), Positives = 163/274 (59%), Gaps = 6/274 (2%)
Query: 99 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 158
EDF+ K LG GSF V+L + AT + YA+KIL+K+ ++K ++ + E+ ++ ++
Sbjct: 89 EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 148
Query: 159 PFFVKLYFTFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 218
PF V+L + F+ LY + Y GE+ ++R+IG F E RFY A+IV EYLH
Sbjct: 149 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 208
Query: 219 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSA 278
+I+RDLKPEN+L++ +IQ+TDFG AK + + R + GT +Y++PE++ K
Sbjct: 209 DLIYRDLKPENLLIDHQGYIQVTDFGFAKRV-----KGRTWTLCGTPEYLAPEIILSKGY 263
Query: 279 CKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 338
K+ D WALG +IY++ AG PPF A I++KI+ + FP F +DL+ LL +
Sbjct: 264 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 323
Query: 339 DATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 372
D TKR G G +K H +F + W ++Q+
Sbjct: 324 DLTKRFG-NLKNGVSDIKTHKWFATTDWIAIYQR 356
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 207 bits (528), Expect = 1e-53
Identities = 104/274 (37%), Positives = 162/274 (59%), Gaps = 6/274 (2%)
Query: 99 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 158
+ F+ K LG GSF V+L + T YA+KIL+K+ ++K ++ + E+ ++ ++
Sbjct: 34 DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 93
Query: 159 PFFVKLYFTFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 218
PF VKL F+F+ LY + Y GE+ ++R+IG F E RFY A+IV EYLH
Sbjct: 94 PFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 153
Query: 219 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSA 278
+I+RDLKPEN+L+++ +IQ+TDFG AK + + R + GT +Y++PE++ K
Sbjct: 154 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-----KGRTWTLCGTPEYLAPEIILSKGY 208
Query: 279 CKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 338
K+ D WALG +IY++ AG PPF A I++KI+ + FP F +DL+ LL +
Sbjct: 209 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 268
Query: 339 DATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 372
D TKR G G +K H +F + W ++Q+
Sbjct: 269 DLTKRFG-NLKNGVNDIKNHKWFATTDWIAIYQR 301
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 207 bits (528), Expect = 1e-53
Identities = 104/274 (37%), Positives = 162/274 (59%), Gaps = 6/274 (2%)
Query: 99 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 158
+ F+ K LG GSF V+L + T YA+KIL+K+ ++K ++ + E+ ++ ++
Sbjct: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101
Query: 159 PFFVKLYFTFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 218
PF VKL F+F+ LY + Y GE+ ++R+IG F E RFY A+IV EYLH
Sbjct: 102 PFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161
Query: 219 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSA 278
+I+RDLKPEN+L+++ +IQ+TDFG AK + + R + GT +Y++PE++ K
Sbjct: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-----KGRTWTLCGTPEYLAPEIILSKGY 216
Query: 279 CKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 338
K+ D WALG +IY++ AG PPF A I++KI+ + FP F +DL+ LL +
Sbjct: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 276
Query: 339 DATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 372
D TKR G G +K H +F + W ++Q+
Sbjct: 277 DLTKRFG-NLKNGVNDIKNHKWFATTDWIAIYQR 309
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 204 bits (519), Expect = 1e-52
Identities = 107/303 (35%), Positives = 169/303 (55%), Gaps = 11/303 (3%)
Query: 91 PQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRER 150
P + F+ + LG GSF V+L R T YA+KIL K+ ++K +V ++ E+
Sbjct: 34 PAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEK 93
Query: 151 DVMSRLDHPFFVKLYFTFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVS 210
++ +D PF VKL F+F+ LY + Y GE+ ++++G F E FY A++V
Sbjct: 94 RILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVL 153
Query: 211 ALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSP 270
A++YLH +IHRDLKPEN+L+++ ++Q+TDFG AK + + R + GT +Y++P
Sbjct: 154 AVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRV-----KGRTWTLCGTPEYLAP 208
Query: 271 ELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARD 330
E++ K K+ D WALG +IY++ G PPF A I++KI+ FP K +
Sbjct: 209 EIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKH 268
Query: 331 LVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTP-----PKLTAYLPAMS 385
L+ LL +D TKR G G G +K H +F + +W ++++ PK T A +
Sbjct: 269 LLRSLLQVDLTKRFG-NLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASN 327
Query: 386 EDD 388
DD
Sbjct: 328 FDD 330
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 203 bits (517), Expect = 2e-52
Identities = 124/348 (35%), Positives = 186/348 (53%), Gaps = 15/348 (4%)
Query: 47 MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 106
MV + P P + G D + E A S A K DF + K+
Sbjct: 105 MVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARA-------KVTMNDFDYLKL 157
Query: 107 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF 166
LG+G+F V+L RE AT R YA+KIL K II +++V + E V+ HPF L +
Sbjct: 158 LGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKY 217
Query: 167 TFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK 226
FQT RL F + YA GEL ++ + F E RFY AEIVSALEYLH + +++RD+K
Sbjct: 218 AFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIK 277
Query: 227 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA 286
EN++L++D HI+ITDFG K S A +F GT +Y++PE+L + ++ D W
Sbjct: 278 LENLMLDKDGHIKITDFGLCK--EGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWG 335
Query: 287 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC 346
LG ++Y+++ G PF + +F+ I+ E FP P+A+ L+ LL D +RLG
Sbjct: 336 LGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGG 395
Query: 347 EEMEGYGPLKAHPFFESVTWENLHQQT-----PPKLTAYLPAMSEDDE 389
+ ++ H FF S+ W+++ Q+ P++T+ + DDE
Sbjct: 396 GPSDAKEVME-HRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDE 442
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 202 bits (514), Expect = 5e-52
Identities = 108/281 (38%), Positives = 162/281 (57%), Gaps = 7/281 (2%)
Query: 93 PRKKRPEDFKFGKILGEGSFSTVVLARELA---TSREYAIKILEKRHIIKENK-VPYVTR 148
P K RPE F+ ++LG+G + V R++ T + +A+K+L+K I++ K +
Sbjct: 83 PEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKA 142
Query: 149 ERDVMSRLDHPFFVKLYFTFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEI 208
ER+++ + HPF V L + FQT +LY L Y GEL + + G F E FY AEI
Sbjct: 143 ERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEI 202
Query: 209 VSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYV 268
AL +LH KGII+RDLKPENI+LN H+++TDFG K + ++F GT +Y+
Sbjct: 203 SMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDG--TVTHTFCGTIEYM 260
Query: 269 SPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKA 328
+PE+L ++ D W+LG ++Y ++ G PPF N KI+K + + P +A
Sbjct: 261 APEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEA 320
Query: 329 RDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENL 369
RDL++KLL +A RLG + G ++AHPFF + WE L
Sbjct: 321 RDLLKKLLKRNAASRLGAGPGDA-GEVQAHPFFRHINWEEL 360
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 200 bits (509), Expect = 2e-51
Identities = 111/323 (34%), Positives = 183/323 (56%), Gaps = 9/323 (2%)
Query: 57 PPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVV 116
PP +P + + P+P + P +P DF F K++G+G++ V+
Sbjct: 51 PPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVL 110
Query: 117 LARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQTTRRLY 175
LA+ + YA+K+L+K+ I+K+ + ++ ER V+ + + HPF V L ++FQT +LY
Sbjct: 111 LAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLY 170
Query: 176 FGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNED 235
F L Y GEL ++++ F E RFY AE+ SA+ YLH II+RDLKPENILL+
Sbjct: 171 FVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQ 230
Query: 236 MHIQITDFGTAKV-LSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQL 294
H+ +TDFG K + PE ++F GT +Y++PE+L ++ ++ D W LG ++Y++
Sbjct: 231 GHVVLTDFGLCKEGVEPED---TTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEM 287
Query: 295 VAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGP 354
+ GLPPF + + +++ I+ P A DL++ LL D +RLG + +
Sbjct: 288 LHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSK--ADFLE 345
Query: 355 LKAHPFFESVTWENLHQQ--TPP 375
+K H FF + W++L+ + TPP
Sbjct: 346 IKNHVFFSPINWDDLYHKRLTPP 368
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 198 bits (503), Expect = 1e-50
Identities = 107/284 (37%), Positives = 166/284 (58%), Gaps = 5/284 (1%)
Query: 94 RKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVM 153
++K DF + K+LG+G+F V+L RE A+ + YA+KIL+K II +++V + E V+
Sbjct: 141 KRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL 200
Query: 154 SRLDHPFFVKLYFTFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALE 213
HPF L ++FQT RL F + Y GEL ++ + F E TRFY AEIVSAL+
Sbjct: 201 KNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALD 260
Query: 214 YLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELL 273
YLH I++RDLK EN++L++D HI+ITDFG K + A +F GT +Y++PE+L
Sbjct: 261 YLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCK--EGITDAATMKTFCGTPEYLAPEVL 318
Query: 274 TEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVE 333
+ ++ D W LG ++Y+++ G PF + +F+ I+ + FP A+ L+
Sbjct: 319 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLS 378
Query: 334 KLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ--TPP 375
LL+ D KRLG + + H FF V W++++ + PP
Sbjct: 379 GLLIKDPNKRLG-GGPDDAKEIMRHSFFSGVNWQDVYDKKLVPP 421
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 198 bits (503), Expect = 1e-50
Identities = 107/284 (37%), Positives = 166/284 (58%), Gaps = 5/284 (1%)
Query: 94 RKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVM 153
++K DF + K+LG+G+F V+L RE A+ + YA+KIL+K II +++V + E V+
Sbjct: 141 KRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL 200
Query: 154 SRLDHPFFVKLYFTFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALE 213
HPF L ++FQT RL F + Y GEL ++ + F E TRFY AEIVSAL+
Sbjct: 201 KNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALD 260
Query: 214 YLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELL 273
YLH I++RDLK EN++L++D HI+ITDFG K + A +F GT +Y++PE+L
Sbjct: 261 YLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCK--EGITDAATMKTFCGTPEYLAPEVL 318
Query: 274 TEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVE 333
+ ++ D W LG ++Y+++ G PF + +F+ I+ + FP A+ L+
Sbjct: 319 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLS 378
Query: 334 KLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ--TPP 375
LL+ D KRLG + + H FF V W++++ + PP
Sbjct: 379 GLLIKDPNKRLG-GGPDDAKEIMRHSFFSGVNWQDVYDKKLVPP 421
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 198 bits (503), Expect = 1e-50
Identities = 107/288 (37%), Positives = 170/288 (59%), Gaps = 6/288 (2%)
Query: 89 PPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTR 148
P P K P DF F K++G+GSF V+LA+ + YA+K+L+K+ ++ + ++
Sbjct: 151 PSGNPHAK-PTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMA 209
Query: 149 ERDVMSR-LDHPFFVKLYFTFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAE 207
ER+V+ + + HPF V L+++FQTT +LYF L + GEL ++++ SF E RFY AE
Sbjct: 210 ERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAE 269
Query: 208 IVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQY 267
I SAL YLH I++RDLKPENILL+ H+ +TDFG K + +F GT +Y
Sbjct: 270 IASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCK--EGIAISDTTTTFCGTPEY 327
Query: 268 VSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPK 327
++PE++ ++ + D W LG ++Y+++ GLPPF + ++ I+
Sbjct: 328 LAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLT 387
Query: 328 ARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPP 375
A ++E+LL D RLG + E + ++ HPFFES++W +L Q+ P
Sbjct: 388 AWSILEELLEKDRQNRLGAK--EDFLEIQNHPFFESLSWADLVQKKIP 433
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 198 bits (503), Expect = 1e-50
Identities = 107/288 (37%), Positives = 170/288 (59%), Gaps = 6/288 (2%)
Query: 89 PPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTR 148
P P K P DF F K++G+GSF V+LA+ + YA+K+L+K+ ++ + ++
Sbjct: 151 PSGNPHAK-PTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMA 209
Query: 149 ERDVMSR-LDHPFFVKLYFTFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAE 207
ER+V+ + + HPF V L+++FQTT +LYF L + GEL ++++ SF E RFY AE
Sbjct: 210 ERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAE 269
Query: 208 IVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQY 267
I SAL YLH I++RDLKPENILL+ H+ +TDFG K + +F GT +Y
Sbjct: 270 IASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCK--EGIAISDTTTTFCGTPEY 327
Query: 268 VSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPK 327
++PE++ ++ + D W LG ++Y+++ GLPPF + ++ I+
Sbjct: 328 LAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLT 387
Query: 328 ARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPP 375
A ++E+LL D RLG + E + ++ HPFFES++W +L Q+ P
Sbjct: 388 AWSILEELLEKDRQNRLGAK--EDFLEIQNHPFFESLSWADLVQKKIP 433
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 197 bits (502), Expect = 1e-50
Identities = 108/303 (35%), Positives = 177/303 (58%), Gaps = 9/303 (2%)
Query: 77 PRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRH 136
P+P + P +P DF F K++G+G++ V+LA+ + YA+K+L+K+
Sbjct: 11 PQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKS 70
Query: 137 IIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQTTRRLYFGLSYAKNGELLKYIRKIGS 195
I+K+ + ++ ER V+ + + HPF V L ++FQT +LYF L Y GEL ++++
Sbjct: 71 ILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERR 130
Query: 196 FDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKV-LSPESK 254
F E RFY AE+ SA+ YLH II+RDLKPENILL+ H+ +TDFG K + PE
Sbjct: 131 FLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPED- 189
Query: 255 QARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKII 314
++F GT +Y++PE+L ++ ++ D W LG ++Y+++ GLPPF + + +++ I+
Sbjct: 190 --TTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENIL 247
Query: 315 KLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ-- 372
P A DL++ LL D +RLG + + +K H FF + W++L+ +
Sbjct: 248 HQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSK--ADFLEIKNHVFFSPINWDDLYHKRL 305
Query: 373 TPP 375
TPP
Sbjct: 306 TPP 308
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 197 bits (501), Expect = 2e-50
Identities = 111/310 (35%), Positives = 180/310 (58%), Gaps = 7/310 (2%)
Query: 70 MDGTAAEPRPGAGSLQHAQPPPQPRKK-RPEDFKFGKILGEGSFSTVVLARELATSREYA 128
MD + P +G+ + +P+ + +F++ K+LG+G+F V+L +E AT R YA
Sbjct: 118 MDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYA 177
Query: 129 IKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQTTRRLYFGLSYAKNGELLK 188
+KIL+K I+ +++V + E V+ HPF L ++FQT RL F + YA GEL
Sbjct: 178 MKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFF 237
Query: 189 YIRKIGSFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENILLNEDMHIQITDFGTAK 247
++ + F E RFY AEIVSAL+YLH K +++RDLK EN++L++D HI+ITDFG K
Sbjct: 238 HLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK 297
Query: 248 VLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEY 307
+ A +F GT +Y++PE+L + ++ D W LG ++Y+++ G PF +
Sbjct: 298 EGIKDG--ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE 355
Query: 308 LIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWE 367
+F+ I+ E FP P+A+ L+ LL D +RLG E + H FF + W+
Sbjct: 356 KLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG-GGSEDAKEIMQHRFFAGIVWQ 414
Query: 368 NLHQQ--TPP 375
+++++ +PP
Sbjct: 415 HVYEKKLSPP 424
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 197 bits (501), Expect = 2e-50
Identities = 111/310 (35%), Positives = 180/310 (58%), Gaps = 7/310 (2%)
Query: 70 MDGTAAEPRPGAGSLQHAQPPPQPRKK-RPEDFKFGKILGEGSFSTVVLARELATSREYA 128
MD + P +G+ + +P+ + +F++ K+LG+G+F V+L +E AT R YA
Sbjct: 118 MDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYA 177
Query: 129 IKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQTTRRLYFGLSYAKNGELLK 188
+KIL+K I+ +++V + E V+ HPF L ++FQT RL F + YA GEL
Sbjct: 178 MKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFF 237
Query: 189 YIRKIGSFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENILLNEDMHIQITDFGTAK 247
++ + F E RFY AEIVSAL+YLH K +++RDLK EN++L++D HI+ITDFG K
Sbjct: 238 HLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK 297
Query: 248 VLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEY 307
+ A +F GT +Y++PE+L + ++ D W LG ++Y+++ G PF +
Sbjct: 298 EGIKDG--ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE 355
Query: 308 LIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWE 367
+F+ I+ E FP P+A+ L+ LL D +RLG E + H FF + W+
Sbjct: 356 KLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG-GGSEDAKEIMQHRFFAGIVWQ 414
Query: 368 NLHQQ--TPP 375
+++++ +PP
Sbjct: 415 HVYEKKLSPP 424
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 197 bits (501), Expect = 2e-50
Identities = 111/310 (35%), Positives = 180/310 (58%), Gaps = 7/310 (2%)
Query: 70 MDGTAAEPRPGAGSLQHAQPPPQPRKK-RPEDFKFGKILGEGSFSTVVLARELATSREYA 128
MD + P +G+ + +P+ + +F++ K+LG+G+F V+L +E AT R YA
Sbjct: 118 MDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYA 177
Query: 129 IKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQTTRRLYFGLSYAKNGELLK 188
+KIL+K I+ +++V + E V+ HPF L ++FQT RL F + YA GEL
Sbjct: 178 MKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFF 237
Query: 189 YIRKIGSFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENILLNEDMHIQITDFGTAK 247
++ + F E RFY AEIVSAL+YLH K +++RDLK EN++L++D HI+ITDFG K
Sbjct: 238 HLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK 297
Query: 248 VLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEY 307
+ A +F GT +Y++PE+L + ++ D W LG ++Y+++ G PF +
Sbjct: 298 EGIKDG--ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE 355
Query: 308 LIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWE 367
+F+ I+ E FP P+A+ L+ LL D +RLG E + H FF + W+
Sbjct: 356 KLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG-GGSEDAKEIMQHRFFAGIVWQ 414
Query: 368 NLHQQ--TPP 375
+++++ +PP
Sbjct: 415 HVYEKKLSPP 424
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 195 bits (495), Expect = 9e-50
Identities = 107/286 (37%), Positives = 164/286 (57%), Gaps = 4/286 (1%)
Query: 88 QPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVT 147
QP + + DF F +LG+GSF V+LA T YAIKIL+K +I+++ V
Sbjct: 326 QPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTM 385
Query: 148 RERDVMSRLDHP-FFVKLYFTFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTA 206
E+ V++ LD P F +L+ FQT RLYF + Y G+L+ +I+++G F E FY A
Sbjct: 386 VEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAA 445
Query: 207 EIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQ 266
EI L +LH +GII+RDLK +N++L+ + HI+I DFG K + R +F GT
Sbjct: 446 EISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTR--TFCGTPD 503
Query: 267 YVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFP 326
Y++PE++ + KS D WA G ++Y+++AG PPF +E +FQ I++ +P+
Sbjct: 504 YIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSK 563
Query: 327 KARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 372
+A + + L+ KRLGC EG ++ H FF + WE L +
Sbjct: 564 EAVSICKGLMTKHPAKRLGCGP-EGERDVREHAFFRRIDWEKLENR 608
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 195 bits (495), Expect = 9e-50
Identities = 112/338 (33%), Positives = 191/338 (56%), Gaps = 16/338 (4%)
Query: 95 KKRPEDFKFGKILGEGSFSTVVLARELATS---REYAIKILEKRHIIKENKVPYVTRERD 151
K P F+ K+LG+GSF V L ++++ S + YA+K+L+K + ++V ERD
Sbjct: 62 KADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVR-TKMERD 120
Query: 152 VMSRLDHPFFVKLYFTFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSA 211
++ ++HPF VKL++ FQT +LY L + + G+L + K F E +FY AE+ A
Sbjct: 121 ILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 180
Query: 212 LEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPE 271
L++LH GII+RDLKPENILL+E+ HI++TDFG +K K +A SF GT +Y++PE
Sbjct: 181 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEK--KAYSFCGTVEYMAPE 238
Query: 272 LLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDL 331
++ + +S+D W+ G ++++++ G PF+ + I+K + P+ P+A+ L
Sbjct: 239 VVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSL 298
Query: 332 VEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQT--PPKLTAYLPAMSEDDE 389
+ L + RLG +G +K H FF ++ W L+++ PP + PA ++
Sbjct: 299 LRMLFKRNPANRLGAGP-DGVEEIKRHSFFSTIDWNKLYRREIHPP----FKPATGRPED 353
Query: 390 DCYGNG--AARTGRRAPPALAPGSHVRGLLPGLSHLRL 425
Y + A+T + + P + P ++ L G S + +
Sbjct: 354 TFYFDPEFTAKTPKDS-PGIPPSANAHQLFRGFSFVAI 390
Score = 105 bits (263), Expect = 7e-23
Identities = 84/277 (30%), Positives = 130/277 (46%), Gaps = 29/277 (10%)
Query: 107 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL-DHPFFVKLY 165
+G GS+S AT+ E+A+KI++K + P T E +++ R HP + L
Sbjct: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDK-----SKRDP--TEEIEILLRYGQHPNIITLK 480
Query: 166 FTFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDL 225
+ + +Y K GELL I + F E I +EYLH +G++HRDL
Sbjct: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540
Query: 226 KPENILLNEDM----HIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKS 281
KP NIL ++ I+I DFG AK L E+ + TA +V+PE+L + +
Sbjct: 541 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCY--TANFVAPEVLKRQGYDAA 598
Query: 282 SDLWALGCIIYQLVAGLPPFRAGNEYL---IFQKI----IKLEYDFPEKFFPKARDLVEK 334
D+W+LG ++Y ++ G PF G + I +I L + A+DLV K
Sbjct: 599 CDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSK 658
Query: 335 LLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQ 371
+L +D +RL + HP+ V W+ L Q
Sbjct: 659 MLHVDPHQRLTA------ALVLRHPWI--VHWDQLPQ 687
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 193 bits (491), Expect = 2e-49
Identities = 103/279 (36%), Positives = 163/279 (58%), Gaps = 4/279 (1%)
Query: 99 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL-D 157
++F+F ++LG+GSF V+LAR T YA+K+L+K I++++ V E+ ++S +
Sbjct: 353 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 412
Query: 158 HPFFVKLYFTFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHG 217
HPF +L+ FQT RL+F + + G+L+ +I+K FDE RFY AEI+SAL +LH
Sbjct: 413 HPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHD 472
Query: 218 KGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKS 277
KGII+RDLK +N+LL+ + H ++ DFG K +F GT Y++PE+L E
Sbjct: 473 KGIIYRDLKLDNVLLDHEGHCKLADFGMCK--EGICNGVTTATFCGTPDYIAPEILQEML 530
Query: 278 ACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLV 337
+ D WA+G ++Y+++ G PF A NE +F+ I+ E +P A +++ +
Sbjct: 531 YGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT 590
Query: 338 LDATKRLGCEEMEGYGPLKAHPFFESVTWENL-HQQTPP 375
+ T RLG G + HPFF+ + W L H+Q P
Sbjct: 591 KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEP 629
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 192 bits (489), Expect = 4e-49
Identities = 103/283 (36%), Positives = 163/283 (57%), Gaps = 4/283 (1%)
Query: 92 QPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERD 151
Q ++ ++F F K+LG+GSF V+LA YA+K+L+K I++++ V E+
Sbjct: 399 QAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKR 458
Query: 152 VMSRL-DHPFFVKLYFTFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVS 210
+++ HP+ +LY FQT RL+F + Y G+L+ I++ FDE +RFY AE+ S
Sbjct: 459 ILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTS 518
Query: 211 ALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSP 270
AL +LH G+I+RDLK +NILL+ + H ++ DFG K +F GT Y++P
Sbjct: 519 ALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCK--EGILNGVTTTTFCGTPDYIAP 576
Query: 271 ELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARD 330
E+L E S D WALG ++Y+++AG PPF A NE +F+ I+ + +P +A
Sbjct: 577 EILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVS 636
Query: 331 LVEKLLVLDATKRLGC-EEMEGYGPLKAHPFFESVTWENLHQQ 372
+++ + + KRLGC G +K HPFF+ + W L Q+
Sbjct: 637 ILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQK 679
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 192 bits (489), Expect = 4e-49
Identities = 115/326 (35%), Positives = 177/326 (54%), Gaps = 20/326 (6%)
Query: 57 PPGIPGGSRQGPAMDGTAAE-PRPGAGSLQHAQPPPQPRKKRP--------EDFKFGKIL 107
PP +P ++ P G + E P + H P P+ K+RP EDF K+L
Sbjct: 330 PPCLPTPGKREP--QGISWESPLDEVDKMCHL-PEPELNKERPSLQIKLKIEDFILHKML 386
Query: 108 GEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL-DHPFFVKLYF 166
G+GSF V LA T++ +AIK L+K ++ ++ V E+ V+S +HPF ++
Sbjct: 387 GKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFC 446
Query: 167 TFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK 226
TFQT L+F + Y G+L+ +I+ FD + FY AEI+ L++LH KGI++RDLK
Sbjct: 447 TFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLK 506
Query: 227 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA 286
+NILL++D HI+I DFG K A+ N+F GT Y++PE+L + S D W+
Sbjct: 507 LDNILLDKDGHIKIADFGMCK--ENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWS 564
Query: 287 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC 346
G ++Y+++ G PF +E +F I +P +A+DL+ KL V + KRLG
Sbjct: 565 FGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGV 624
Query: 347 EEMEGYGPLKAHPFFESVTWENLHQQ 372
G ++ HP F + WE L ++
Sbjct: 625 R-----GDIRQHPLFREINWEELERK 645
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,625,438
Number of Sequences: 37866
Number of extensions: 1093236
Number of successful extensions: 7556
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 758
Number of HSP's successfully gapped in prelim test: 135
Number of HSP's that attempted gapping in prelim test: 4962
Number of HSP's gapped (non-prelim): 1272
length of query: 471
length of database: 18,247,518
effective HSP length: 106
effective length of query: 365
effective length of database: 14,233,722
effective search space: 5195308530
effective search space used: 5195308530
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.