BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo sapiens] (396 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo ... 817 0.0 gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform... 710 0.0 gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent ... 704 0.0 gi|47680169 3-phosphoinositide dependent protein kinase-1 isofor... 289 3e-78 gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 216 3e-56 gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 216 3e-56 gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 216 3e-56 gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 216 3e-56 gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 214 1e-55 gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 214 1e-55 gi|4826948 protein kinase, X-linked [Homo sapiens] 214 1e-55 gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 211 9e-55 gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 211 9e-55 gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 207 1e-53 gi|4502023 AKT2 kinase [Homo sapiens] 202 4e-52 gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 201 7e-52 gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 201 1e-51 gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 198 6e-51 gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 197 1e-50 gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 197 1e-50 gi|62241015 AKT1 kinase [Homo sapiens] 197 1e-50 gi|62241013 AKT1 kinase [Homo sapiens] 197 1e-50 gi|62241011 AKT1 kinase [Homo sapiens] 197 1e-50 gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 196 2e-50 gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 196 2e-50 gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 192 4e-49 gi|5453976 protein kinase C, theta [Homo sapiens] 192 4e-49 gi|4506067 protein kinase C, alpha [Homo sapiens] 192 6e-49 gi|28557781 protein kinase C, eta [Homo sapiens] 191 8e-49 gi|4885563 protein kinase C, epsilon [Homo sapiens] 191 1e-48 >gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo sapiens] Length = 396 Score = 817 bits (2110), Expect = 0.0 Identities = 396/396 (100%), Positives = 396/396 (100%) Query: 1 MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 60 MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI Sbjct: 1 MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 60 Query: 61 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF 120 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF Sbjct: 61 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF 120 Query: 121 TFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK 180 TFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK Sbjct: 121 TFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK 180 Query: 181 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA 240 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA Sbjct: 181 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA 240 Query: 241 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC 300 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC Sbjct: 241 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC 300 Query: 301 EEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNVSWPGWRARQVA 360 EEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNVSWPGWRARQVA Sbjct: 301 EEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNVSWPGWRARQVA 360 Query: 361 LGPPCTGLHARAPDPRVICSRKGRVSVPLRQACWWL 396 LGPPCTGLHARAPDPRVICSRKGRVSVPLRQACWWL Sbjct: 361 LGPPCTGLHARAPDPRVICSRKGRVSVPLRQACWWL 396 >gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform 1 [Homo sapiens] Length = 556 Score = 710 bits (1832), Expect = 0.0 Identities = 348/348 (100%), Positives = 348/348 (100%) Query: 1 MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 60 MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI Sbjct: 28 MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 87 Query: 61 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF 120 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF Sbjct: 88 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF 147 Query: 121 TFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK 180 TFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK Sbjct: 148 TFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK 207 Query: 181 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA 240 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA Sbjct: 208 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA 267 Query: 241 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC 300 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC Sbjct: 268 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC 327 Query: 301 EEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGN 348 EEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGN Sbjct: 328 EEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGN 375 >gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent protein kinase-1 [Homo sapiens] Length = 471 Score = 704 bits (1817), Expect = 0.0 Identities = 351/371 (94%), Positives = 353/371 (95%), Gaps = 3/371 (0%) Query: 1 MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 60 MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI Sbjct: 47 MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 106 Query: 61 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF 120 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF Sbjct: 107 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF 166 Query: 121 TFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK 180 TFQ +LYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK Sbjct: 167 TFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK 226 Query: 181 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA 240 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA Sbjct: 227 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA 286 Query: 241 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC 300 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC Sbjct: 287 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC 346 Query: 301 EEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNVSWPGWRARQVA 360 EEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGN + R A Sbjct: 347 EEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNGAARTGRRAPPA 406 Query: 361 LGPPCTGLHAR 371 L P G H R Sbjct: 407 LAP---GSHVR 414 >gi|47680169 3-phosphoinositide dependent protein kinase-1 isoform 2 [Homo sapiens] Length = 429 Score = 289 bits (739), Expect = 3e-78 Identities = 138/138 (100%), Positives = 138/138 (100%) Query: 211 RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL 270 RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL Sbjct: 111 RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL 170 Query: 271 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPK 330 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPK Sbjct: 171 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPK 230 Query: 331 LTAYLPAMSEDDEDCYGN 348 LTAYLPAMSEDDEDCYGN Sbjct: 231 LTAYLPAMSEDDEDCYGN 248 Score = 169 bits (429), Expect = 3e-42 Identities = 82/84 (97%), Positives = 83/84 (98%) Query: 1 MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 60 MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI Sbjct: 28 MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 87 Query: 61 LGEGSFSTVVLARELATSREYAIK 84 LGEGSFSTVVLARELATSREYA + Sbjct: 88 LGEGSFSTVVLARELATSREYATR 111 >gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo sapiens] Length = 431 Score = 216 bits (550), Expect = 3e-56 Identities = 120/313 (38%), Positives = 180/313 (57%), Gaps = 8/313 (2%) Query: 20 QGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSR 79 Q P + P P + P P K P DF F K++G+GSF V+LAR A Sbjct: 64 QEPELMNANPSPPPSPSQQINLGPSSNPHAK-PSDFHFLKVIGKGSFGKVLLARHKAEEV 122 Query: 80 EYAIKILEKRHIIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQDDEKLYFGLSYAKNG 138 YA+K+L+K+ I+K+ + ++ ER+V+ + + HPF V L+F+FQ +KLYF L Y G Sbjct: 123 FYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGG 182 Query: 139 ELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG 198 EL ++++ F E RFY AEI SAL YLH I++RDLKPENILL+ HI +TDFG Sbjct: 183 ELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG 242 Query: 199 TAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAG 258 K + ++F GT +Y++PE+L ++ ++ D W LG ++Y+++ GLPPF + Sbjct: 243 LCK--ENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR 300 Query: 259 NEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESV 318 N ++ I+ AR L+E LL D TKRLG + + + +K+H FF + Sbjct: 301 NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAK--DDFMEIKSHVFFSLI 358 Query: 319 TWENLHQQ--TPP 329 W++L + TPP Sbjct: 359 NWDDLINKKITPP 371 >gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [Homo sapiens] Length = 445 Score = 216 bits (550), Expect = 3e-56 Identities = 120/313 (38%), Positives = 180/313 (57%), Gaps = 8/313 (2%) Query: 20 QGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSR 79 Q P + P P + P P K P DF F K++G+GSF V+LAR A Sbjct: 78 QEPELMNANPSPPPSPSQQINLGPSSNPHAK-PSDFHFLKVIGKGSFGKVLLARHKAEEV 136 Query: 80 EYAIKILEKRHIIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQDDEKLYFGLSYAKNG 138 YA+K+L+K+ I+K+ + ++ ER+V+ + + HPF V L+F+FQ +KLYF L Y G Sbjct: 137 FYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGG 196 Query: 139 ELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG 198 EL ++++ F E RFY AEI SAL YLH I++RDLKPENILL+ HI +TDFG Sbjct: 197 ELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG 256 Query: 199 TAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAG 258 K + ++F GT +Y++PE+L ++ ++ D W LG ++Y+++ GLPPF + Sbjct: 257 LCK--ENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR 314 Query: 259 NEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESV 318 N ++ I+ AR L+E LL D TKRLG + + + +K+H FF + Sbjct: 315 NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAK--DDFMEIKSHVFFSLI 372 Query: 319 TWENLHQQ--TPP 329 W++L + TPP Sbjct: 373 NWDDLINKKITPP 385 >gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [Homo sapiens] Length = 459 Score = 216 bits (550), Expect = 3e-56 Identities = 120/313 (38%), Positives = 180/313 (57%), Gaps = 8/313 (2%) Query: 20 QGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSR 79 Q P + P P + P P K P DF F K++G+GSF V+LAR A Sbjct: 92 QEPELMNANPSPPPSPSQQINLGPSSNPHAK-PSDFHFLKVIGKGSFGKVLLARHKAEEV 150 Query: 80 EYAIKILEKRHIIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQDDEKLYFGLSYAKNG 138 YA+K+L+K+ I+K+ + ++ ER+V+ + + HPF V L+F+FQ +KLYF L Y G Sbjct: 151 FYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGG 210 Query: 139 ELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG 198 EL ++++ F E RFY AEI SAL YLH I++RDLKPENILL+ HI +TDFG Sbjct: 211 ELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG 270 Query: 199 TAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAG 258 K + ++F GT +Y++PE+L ++ ++ D W LG ++Y+++ GLPPF + Sbjct: 271 LCK--ENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR 328 Query: 259 NEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESV 318 N ++ I+ AR L+E LL D TKRLG + + + +K+H FF + Sbjct: 329 NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAK--DDFMEIKSHVFFSLI 386 Query: 319 TWENLHQQ--TPP 329 W++L + TPP Sbjct: 387 NWDDLINKKITPP 399 >gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [Homo sapiens] Length = 526 Score = 216 bits (550), Expect = 3e-56 Identities = 120/313 (38%), Positives = 180/313 (57%), Gaps = 8/313 (2%) Query: 20 QGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSR 79 Q P + P P + P P K P DF F K++G+GSF V+LAR A Sbjct: 159 QEPELMNANPSPPPSPSQQINLGPSSNPHAK-PSDFHFLKVIGKGSFGKVLLARHKAEEV 217 Query: 80 EYAIKILEKRHIIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQDDEKLYFGLSYAKNG 138 YA+K+L+K+ I+K+ + ++ ER+V+ + + HPF V L+F+FQ +KLYF L Y G Sbjct: 218 FYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGG 277 Query: 139 ELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG 198 EL ++++ F E RFY AEI SAL YLH I++RDLKPENILL+ HI +TDFG Sbjct: 278 ELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG 337 Query: 199 TAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAG 258 K + ++F GT +Y++PE+L ++ ++ D W LG ++Y+++ GLPPF + Sbjct: 338 LCK--ENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR 395 Query: 259 NEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESV 318 N ++ I+ AR L+E LL D TKRLG + + + +K+H FF + Sbjct: 396 NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAK--DDFMEIKSHVFFSLI 453 Query: 319 TWENLHQQ--TPP 329 W++L + TPP Sbjct: 454 NWDDLINKKITPP 466 >gi|4506057 cAMP-dependent protein kinase catalytic subunit beta isoform 2 [Homo sapiens] Length = 351 Score = 214 bits (545), Expect = 1e-55 Identities = 106/274 (38%), Positives = 165/274 (60%), Gaps = 6/274 (2%) Query: 53 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 112 EDF+ K LG GSF V+L + AT + YA+KIL+K+ ++K ++ + E+ ++ ++ Sbjct: 42 EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 Query: 113 PFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 172 PF V+L + F+D+ LY + Y GE+ ++R+IG F E RFY A+IV EYLH Sbjct: 102 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 Query: 173 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSA 232 +I+RDLKPEN+L++ +IQ+TDFG AK + + R + GT +Y++PE++ K Sbjct: 162 DLIYRDLKPENLLIDHQGYIQVTDFGFAKRV-----KGRTWTLCGTPEYLAPEIILSKGY 216 Query: 233 CKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 292 K+ D WALG +IY++ AG PPF A I++KI+ + FP F +DL+ LL + Sbjct: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 276 Query: 293 DATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 326 D TKR G G +K H +F + W ++Q+ Sbjct: 277 DLTKRFG-NLKNGVSDIKTHKWFATTDWIAIYQR 309 >gi|33636738 cAMP-dependent protein kinase catalytic subunit beta isoform 1 [Homo sapiens] Length = 398 Score = 214 bits (545), Expect = 1e-55 Identities = 106/274 (38%), Positives = 165/274 (60%), Gaps = 6/274 (2%) Query: 53 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 112 EDF+ K LG GSF V+L + AT + YA+KIL+K+ ++K ++ + E+ ++ ++ Sbjct: 89 EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 148 Query: 113 PFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 172 PF V+L + F+D+ LY + Y GE+ ++R+IG F E RFY A+IV EYLH Sbjct: 149 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 208 Query: 173 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSA 232 +I+RDLKPEN+L++ +IQ+TDFG AK + + R + GT +Y++PE++ K Sbjct: 209 DLIYRDLKPENLLIDHQGYIQVTDFGFAKRV-----KGRTWTLCGTPEYLAPEIILSKGY 263 Query: 233 CKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 292 K+ D WALG +IY++ AG PPF A I++KI+ + FP F +DL+ LL + Sbjct: 264 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 323 Query: 293 DATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 326 D TKR G G +K H +F + W ++Q+ Sbjct: 324 DLTKRFG-NLKNGVSDIKTHKWFATTDWIAIYQR 356 >gi|4826948 protein kinase, X-linked [Homo sapiens] Length = 358 Score = 214 bits (545), Expect = 1e-55 Identities = 110/282 (39%), Positives = 169/282 (59%), Gaps = 6/282 (2%) Query: 45 PQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRER 104 P+P +DF +G G+F V L +E +A+K++ +I+ + +V E+ Sbjct: 39 PEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEK 98 Query: 105 DVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVS 164 V+ + HPF ++L++T+ D+ LY + Y GEL Y+R G F T FY+AEI+ Sbjct: 99 SVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIIC 158 Query: 165 ALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSP 224 A+EYLH K I++RDLKPENILL+ D HI++TDFG AK L R + GT +Y++P Sbjct: 159 AIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVD-----RTWTLCGTPEYLAP 213 Query: 225 ELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARD 284 E++ K ++ D WALG +I+++++G PPF N + I+QKI+ + DFP +D Sbjct: 214 EVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKD 273 Query: 285 LVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 326 L++KLLV+D T+RLG G +K H +F SV WE + Q+ Sbjct: 274 LIKKLLVVDRTRRLG-NMKNGANDVKHHRWFRSVDWEAVPQR 314 >gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha isoform 2 [Homo sapiens] Length = 343 Score = 211 bits (537), Expect = 9e-55 Identities = 105/274 (38%), Positives = 164/274 (59%), Gaps = 6/274 (2%) Query: 53 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 112 + F+ K LG GSF V+L + T YA+KIL+K+ ++K ++ + E+ ++ ++ Sbjct: 34 DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 93 Query: 113 PFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 172 PF VKL F+F+D+ LY + Y GE+ ++R+IG F E RFY A+IV EYLH Sbjct: 94 PFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 153 Query: 173 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSA 232 +I+RDLKPEN+L+++ +IQ+TDFG AK + + R + GT +Y++PE++ K Sbjct: 154 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-----KGRTWTLCGTPEYLAPEIILSKGY 208 Query: 233 CKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 292 K+ D WALG +IY++ AG PPF A I++KI+ + FP F +DL+ LL + Sbjct: 209 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 268 Query: 293 DATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 326 D TKR G G +K H +F + W ++Q+ Sbjct: 269 DLTKRFG-NLKNGVNDIKNHKWFATTDWIAIYQR 301 >gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha isoform 1 [Homo sapiens] Length = 351 Score = 211 bits (537), Expect = 9e-55 Identities = 105/274 (38%), Positives = 164/274 (59%), Gaps = 6/274 (2%) Query: 53 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 112 + F+ K LG GSF V+L + T YA+KIL+K+ ++K ++ + E+ ++ ++ Sbjct: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 Query: 113 PFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 172 PF VKL F+F+D+ LY + Y GE+ ++R+IG F E RFY A+IV EYLH Sbjct: 102 PFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 Query: 173 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSA 232 +I+RDLKPEN+L+++ +IQ+TDFG AK + + R + GT +Y++PE++ K Sbjct: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-----KGRTWTLCGTPEYLAPEIILSKGY 216 Query: 233 CKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 292 K+ D WALG +IY++ AG PPF A I++KI+ + FP F +DL+ LL + Sbjct: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 276 Query: 293 DATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 326 D TKR G G +K H +F + W ++Q+ Sbjct: 277 DLTKRFG-NLKNGVNDIKNHKWFATTDWIAIYQR 309 >gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo sapiens] Length = 351 Score = 207 bits (528), Expect = 1e-53 Identities = 108/303 (35%), Positives = 171/303 (56%), Gaps = 11/303 (3%) Query: 45 PQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRER 104 P + F+ + LG GSF V+L R T YA+KIL K+ ++K +V ++ E+ Sbjct: 34 PAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEK 93 Query: 105 DVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVS 164 ++ +D PF VKL F+F+D+ LY + Y GE+ ++++G F E FY A++V Sbjct: 94 RILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVL 153 Query: 165 ALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSP 224 A++YLH +IHRDLKPEN+L+++ ++Q+TDFG AK + + R + GT +Y++P Sbjct: 154 AVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRV-----KGRTWTLCGTPEYLAP 208 Query: 225 ELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARD 284 E++ K K+ D WALG +IY++ G PPF A I++KI+ FP K + Sbjct: 209 EIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKH 268 Query: 285 LVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTP-----PKLTAYLPAMS 339 L+ LL +D TKR G G G +K H +F + +W ++++ PK T A + Sbjct: 269 LLRSLLQVDLTKRFG-NLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASN 327 Query: 340 EDD 342 DD Sbjct: 328 FDD 330 >gi|4502023 AKT2 kinase [Homo sapiens] Length = 481 Score = 202 bits (514), Expect = 4e-52 Identities = 125/369 (33%), Positives = 193/369 (52%), Gaps = 25/369 (6%) Query: 1 MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 60 MV + P P + G D + E A S A K DF + K+ Sbjct: 105 MVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARA-------KVTMNDFDYLKL 157 Query: 61 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF 120 LG+G+F V+L RE AT R YA+KIL K II +++V + E V+ HPF L + Sbjct: 158 LGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKY 217 Query: 121 TFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK 180 FQ ++L F + YA GEL ++ + F E RFY AEIVSALEYLH + +++RD+K Sbjct: 218 AFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIK 277 Query: 181 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA 240 EN++L++D HI+ITDFG K S A +F GT +Y++PE+L + ++ D W Sbjct: 278 LENLMLDKDGHIKITDFGLCK--EGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWG 335 Query: 241 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC 300 LG ++Y+++ G PF + +F+ I+ E FP P+A+ L+ LL D +RLG Sbjct: 336 LGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGG 395 Query: 301 EEMEGYGPLKAHPFFESVTWENLHQQT-----PPKLTAYLPAMSEDDEDCYGNVSWPGWR 355 + ++ H FF S+ W+++ Q+ P++T+ + DDE + Sbjct: 396 GPSDAKEVME-HRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDE----------FT 444 Query: 356 ARQVALGPP 364 A+ + + PP Sbjct: 445 AQSITITPP 453 >gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo sapiens] Length = 525 Score = 201 bits (512), Expect = 7e-52 Identities = 108/281 (38%), Positives = 161/281 (57%), Gaps = 7/281 (2%) Query: 47 PRKKRPEDFKFGKILGEGSFSTVVLARELA---TSREYAIKILEKRHIIKENK-VPYVTR 102 P K RPE F+ ++LG+G + V R++ T + +A+K+L+K I++ K + Sbjct: 83 PEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKA 142 Query: 103 ERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEI 162 ER+++ + HPF V L + FQ KLY L Y GEL + + G F E FY AEI Sbjct: 143 ERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEI 202 Query: 163 VSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYV 222 AL +LH KGII+RDLKPENI+LN H+++TDFG K + ++F GT +Y+ Sbjct: 203 SMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDG--TVTHTFCGTIEYM 260 Query: 223 SPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKA 282 +PE+L ++ D W+LG ++Y ++ G PPF N KI+K + + P +A Sbjct: 261 APEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEA 320 Query: 283 RDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENL 323 RDL++KLL +A RLG + G ++AHPFF + WE L Sbjct: 321 RDLLKKLLKRNAASRLGAGPGDA-GEVQAHPFFRHINWEEL 360 >gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta [Homo sapiens] Length = 427 Score = 201 bits (511), Expect = 1e-51 Identities = 112/323 (34%), Positives = 183/323 (56%), Gaps = 9/323 (2%) Query: 11 PPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVV 70 PP +P + + P+P + P +P DF F K++G+G++ V+ Sbjct: 51 PPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVL 110 Query: 71 LARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQDDEKLY 129 LA+ + YA+K+L+K+ I+K+ + ++ ER V+ + + HPF V L ++FQ EKLY Sbjct: 111 LAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLY 170 Query: 130 FGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNED 189 F L Y GEL ++++ F E RFY AE+ SA+ YLH II+RDLKPENILL+ Sbjct: 171 FVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQ 230 Query: 190 MHIQITDFGTAKV-LSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQL 248 H+ +TDFG K + PE ++F GT +Y++PE+L ++ ++ D W LG ++Y++ Sbjct: 231 GHVVLTDFGLCKEGVEPED---TTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEM 287 Query: 249 VAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGP 308 + GLPPF + + +++ I+ P A DL++ LL D +RLG + + Sbjct: 288 LHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSK--ADFLE 345 Query: 309 LKAHPFFESVTWENLHQQ--TPP 329 +K H FF + W++L+ + TPP Sbjct: 346 IKNHVFFSPINWDDLYHKRLTPP 368 >gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha [Homo sapiens] Length = 367 Score = 198 bits (504), Expect = 6e-51 Identities = 109/303 (35%), Positives = 177/303 (58%), Gaps = 9/303 (2%) Query: 31 PRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRH 90 P+P + P +P DF F K++G+G++ V+LA+ + YA+K+L+K+ Sbjct: 11 PQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKS 70 Query: 91 IIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGS 149 I+K+ + ++ ER V+ + + HPF V L ++FQ EKLYF L Y GEL ++++ Sbjct: 71 ILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERR 130 Query: 150 FDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKV-LSPESK 208 F E RFY AE+ SA+ YLH II+RDLKPENILL+ H+ +TDFG K + PE Sbjct: 131 FLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPED- 189 Query: 209 QARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKII 268 ++F GT +Y++PE+L ++ ++ D W LG ++Y+++ GLPPF + + +++ I+ Sbjct: 190 --TTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENIL 247 Query: 269 KLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ-- 326 P A DL++ LL D +RLG + + +K H FF + W++L+ + Sbjct: 248 HQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSK--ADFLEIKNHVFFSPINWDDLYHKRL 305 Query: 327 TPP 329 TPP Sbjct: 306 TPP 308 >gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] Length = 479 Score = 197 bits (501), Expect = 1e-50 Identities = 110/319 (34%), Positives = 181/319 (56%), Gaps = 12/319 (3%) Query: 48 RKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVM 107 ++K DF + K+LG+G+F V+L RE A+ + YA+KIL+K II +++V + E V+ Sbjct: 141 KRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL 200 Query: 108 SRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALE 167 HPF L ++FQ ++L F + Y GEL ++ + F E TRFY AEIVSAL+ Sbjct: 201 KNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALD 260 Query: 168 YLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELL 227 YLH I++RDLK EN++L++D HI+ITDFG K + A +F GT +Y++PE+L Sbjct: 261 YLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCK--EGITDAATMKTFCGTPEYLAPEVL 318 Query: 228 TEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVE 287 + ++ D W LG ++Y+++ G PF + +F+ I+ + FP A+ L+ Sbjct: 319 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLS 378 Query: 288 KLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ--TPPKLTAYLPAMSEDDEDC 345 LL+ D KRLG + + H FF V W++++ + PP + P ++ + + Sbjct: 379 GLLIKDPNKRLG-GGPDDAKEIMRHSFFSGVNWQDVYDKKLVPP----FKPQVTSETDTR 433 Query: 346 YGNVSWPGWRARQVALGPP 364 Y + + A+ + + PP Sbjct: 434 YFDEE---FTAQTITITPP 449 >gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] Length = 465 Score = 197 bits (501), Expect = 1e-50 Identities = 110/319 (34%), Positives = 181/319 (56%), Gaps = 12/319 (3%) Query: 48 RKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVM 107 ++K DF + K+LG+G+F V+L RE A+ + YA+KIL+K II +++V + E V+ Sbjct: 141 KRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL 200 Query: 108 SRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALE 167 HPF L ++FQ ++L F + Y GEL ++ + F E TRFY AEIVSAL+ Sbjct: 201 KNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALD 260 Query: 168 YLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELL 227 YLH I++RDLK EN++L++D HI+ITDFG K + A +F GT +Y++PE+L Sbjct: 261 YLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCK--EGITDAATMKTFCGTPEYLAPEVL 318 Query: 228 TEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVE 287 + ++ D W LG ++Y+++ G PF + +F+ I+ + FP A+ L+ Sbjct: 319 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLS 378 Query: 288 KLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ--TPPKLTAYLPAMSEDDEDC 345 LL+ D KRLG + + H FF V W++++ + PP + P ++ + + Sbjct: 379 GLLIKDPNKRLG-GGPDDAKEIMRHSFFSGVNWQDVYDKKLVPP----FKPQVTSETDTR 433 Query: 346 YGNVSWPGWRARQVALGPP 364 Y + + A+ + + PP Sbjct: 434 YFDEE---FTAQTITITPP 449 >gi|62241015 AKT1 kinase [Homo sapiens] Length = 480 Score = 197 bits (501), Expect = 1e-50 Identities = 114/345 (33%), Positives = 195/345 (56%), Gaps = 14/345 (4%) Query: 24 MDGTAAEPRPGAGSLQHAQPPPQPRKK-RPEDFKFGKILGEGSFSTVVLARELATSREYA 82 MD + P +G+ + +P+ + +F++ K+LG+G+F V+L +E AT R YA Sbjct: 118 MDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYA 177 Query: 83 IKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLK 142 +KIL+K I+ +++V + E V+ HPF L ++FQ ++L F + YA GEL Sbjct: 178 MKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFF 237 Query: 143 YIRKIGSFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENILLNEDMHIQITDFGTAK 201 ++ + F E RFY AEIVSAL+YLH K +++RDLK EN++L++D HI+ITDFG K Sbjct: 238 HLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK 297 Query: 202 VLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEY 261 + A +F GT +Y++PE+L + ++ D W LG ++Y+++ G PF + Sbjct: 298 EGIKDG--ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE 355 Query: 262 LIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWE 321 +F+ I+ E FP P+A+ L+ LL D +RLG E + H FF + W+ Sbjct: 356 KLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG-GGSEDAKEIMQHRFFAGIVWQ 414 Query: 322 NLHQQ--TPPKLTAYLPAMSEDDEDCYGNVSWPGWRARQVALGPP 364 +++++ +PP + P ++ + + Y + + A+ + + PP Sbjct: 415 HVYEKKLSPP----FKPQVTSETDTRYFDEE---FTAQMITITPP 452 >gi|62241013 AKT1 kinase [Homo sapiens] Length = 480 Score = 197 bits (501), Expect = 1e-50 Identities = 114/345 (33%), Positives = 195/345 (56%), Gaps = 14/345 (4%) Query: 24 MDGTAAEPRPGAGSLQHAQPPPQPRKK-RPEDFKFGKILGEGSFSTVVLARELATSREYA 82 MD + P +G+ + +P+ + +F++ K+LG+G+F V+L +E AT R YA Sbjct: 118 MDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYA 177 Query: 83 IKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLK 142 +KIL+K I+ +++V + E V+ HPF L ++FQ ++L F + YA GEL Sbjct: 178 MKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFF 237 Query: 143 YIRKIGSFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENILLNEDMHIQITDFGTAK 201 ++ + F E RFY AEIVSAL+YLH K +++RDLK EN++L++D HI+ITDFG K Sbjct: 238 HLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK 297 Query: 202 VLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEY 261 + A +F GT +Y++PE+L + ++ D W LG ++Y+++ G PF + Sbjct: 298 EGIKDG--ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE 355 Query: 262 LIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWE 321 +F+ I+ E FP P+A+ L+ LL D +RLG E + H FF + W+ Sbjct: 356 KLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG-GGSEDAKEIMQHRFFAGIVWQ 414 Query: 322 NLHQQ--TPPKLTAYLPAMSEDDEDCYGNVSWPGWRARQVALGPP 364 +++++ +PP + P ++ + + Y + + A+ + + PP Sbjct: 415 HVYEKKLSPP----FKPQVTSETDTRYFDEE---FTAQMITITPP 452 >gi|62241011 AKT1 kinase [Homo sapiens] Length = 480 Score = 197 bits (501), Expect = 1e-50 Identities = 114/345 (33%), Positives = 195/345 (56%), Gaps = 14/345 (4%) Query: 24 MDGTAAEPRPGAGSLQHAQPPPQPRKK-RPEDFKFGKILGEGSFSTVVLARELATSREYA 82 MD + P +G+ + +P+ + +F++ K+LG+G+F V+L +E AT R YA Sbjct: 118 MDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYA 177 Query: 83 IKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLK 142 +KIL+K I+ +++V + E V+ HPF L ++FQ ++L F + YA GEL Sbjct: 178 MKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFF 237 Query: 143 YIRKIGSFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENILLNEDMHIQITDFGTAK 201 ++ + F E RFY AEIVSAL+YLH K +++RDLK EN++L++D HI+ITDFG K Sbjct: 238 HLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK 297 Query: 202 VLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEY 261 + A +F GT +Y++PE+L + ++ D W LG ++Y+++ G PF + Sbjct: 298 EGIKDG--ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE 355 Query: 262 LIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWE 321 +F+ I+ E FP P+A+ L+ LL D +RLG E + H FF + W+ Sbjct: 356 KLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG-GGSEDAKEIMQHRFFAGIVWQ 414 Query: 322 NLHQQ--TPPKLTAYLPAMSEDDEDCYGNVSWPGWRARQVALGPP 364 +++++ +PP + P ++ + + Y + + A+ + + PP Sbjct: 415 HVYEKKLSPP----FKPQVTSETDTRYFDEE---FTAQMITITPP 452 >gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo sapiens] Length = 496 Score = 196 bits (499), Expect = 2e-50 Identities = 107/288 (37%), Positives = 169/288 (58%), Gaps = 6/288 (2%) Query: 43 PPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTR 102 P P K P DF F K++G+GSF V+LA+ + YA+K+L+K+ ++ + ++ Sbjct: 151 PSGNPHAK-PTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMA 209 Query: 103 ERDVMSR-LDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAE 161 ER+V+ + + HPF V L+++FQ EKLYF L + GEL ++++ SF E RFY AE Sbjct: 210 ERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAE 269 Query: 162 IVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQY 221 I SAL YLH I++RDLKPENILL+ H+ +TDFG K + +F GT +Y Sbjct: 270 IASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCK--EGIAISDTTTTFCGTPEY 327 Query: 222 VSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPK 281 ++PE++ ++ + D W LG ++Y+++ GLPPF + ++ I+ Sbjct: 328 LAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLT 387 Query: 282 ARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPP 329 A ++E+LL D RLG + E + ++ HPFFES++W +L Q+ P Sbjct: 388 AWSILEELLEKDRQNRLGAK--EDFLEIQNHPFFESLSWADLVQKKIP 433 >gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo sapiens] Length = 496 Score = 196 bits (499), Expect = 2e-50 Identities = 107/288 (37%), Positives = 169/288 (58%), Gaps = 6/288 (2%) Query: 43 PPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTR 102 P P K P DF F K++G+GSF V+LA+ + YA+K+L+K+ ++ + ++ Sbjct: 151 PSGNPHAK-PTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMA 209 Query: 103 ERDVMSR-LDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAE 161 ER+V+ + + HPF V L+++FQ EKLYF L + GEL ++++ SF E RFY AE Sbjct: 210 ERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAE 269 Query: 162 IVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQY 221 I SAL YLH I++RDLKPENILL+ H+ +TDFG K + +F GT +Y Sbjct: 270 IASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCK--EGIAISDTTTTFCGTPEY 327 Query: 222 VSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPK 281 ++PE++ ++ + D W LG ++Y+++ GLPPF + ++ I+ Sbjct: 328 LAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLT 387 Query: 282 ARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPP 329 A ++E+LL D RLG + E + ++ HPFFES++W +L Q+ P Sbjct: 388 AWSILEELLEKDRQNRLGAK--EDFLEIQNHPFFESLSWADLVQKKIP 433 >gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo sapiens] Length = 740 Score = 192 bits (488), Expect = 4e-49 Identities = 108/326 (33%), Positives = 181/326 (55%), Gaps = 13/326 (3%) Query: 49 KKRPEDFKFGKILGEGSFSTVVLARELATS---REYAIKILEKRHIIKENKVPYVTRERD 105 K P F+ K+LG+GSF V L ++++ S + YA+K+L+K + ++V ERD Sbjct: 62 KADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVR-TKMERD 120 Query: 106 VMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSA 165 ++ ++HPF VKL++ FQ + KLY L + + G+L + K F E +FY AE+ A Sbjct: 121 ILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 180 Query: 166 LEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPE 225 L++LH GII+RDLKPENILL+E+ HI++TDFG +K K +A SF GT +Y++PE Sbjct: 181 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEK--KAYSFCGTVEYMAPE 238 Query: 226 LLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDL 285 ++ + +S+D W+ G ++++++ G PF+ + I+K + P+ P+A+ L Sbjct: 239 VVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSL 298 Query: 286 VEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQT--PPKLTAYLPAMSEDDE 343 + L + RLG +G +K H FF ++ W L+++ PP + PA ++ Sbjct: 299 LRMLFKRNPANRLGAGP-DGVEEIKRHSFFSTIDWNKLYRREIHPP----FKPATGRPED 353 Query: 344 DCYGNVSWPGWRARQVALGPPCTGLH 369 Y + + + PP H Sbjct: 354 TFYFDPEFTAKTPKDSPGIPPSANAH 379 Score = 108 bits (270), Expect = 8e-24 Identities = 85/277 (30%), Positives = 131/277 (47%), Gaps = 29/277 (10%) Query: 61 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL-DHPFFVKLY 119 +G GS+S AT+ E+A+KI++K + P T E +++ R HP + L Sbjct: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDK-----SKRDP--TEEIEILLRYGQHPNIITLK 480 Query: 120 FTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDL 179 + D + +Y K GELL I + F E I +EYLH +G++HRDL Sbjct: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540 Query: 180 KPENILLNEDM----HIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKS 235 KP NIL ++ I+I DFG AK L E+ + TA +V+PE+L + + Sbjct: 541 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCY--TANFVAPEVLKRQGYDAA 598 Query: 236 SDLWALGCIIYQLVAGLPPFRAGNEYL---IFQKI----IKLEYDFPEKFFPKARDLVEK 288 D+W+LG ++Y ++ G PF G + I +I L + A+DLV K Sbjct: 599 CDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSK 658 Query: 289 LLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQ 325 +L +D +RL + HP+ V W+ L Q Sbjct: 659 MLHVDPHQRLTA------ALVLRHPWI--VHWDQLPQ 687 >gi|5453976 protein kinase C, theta [Homo sapiens] Length = 706 Score = 192 bits (488), Expect = 4e-49 Identities = 115/326 (35%), Positives = 177/326 (54%), Gaps = 20/326 (6%) Query: 11 PPGIPGGSRQGPAMDGTAAE-PRPGAGSLQHAQPPPQPRKKRP--------EDFKFGKIL 61 PP +P ++ P G + E P + H P P+ K+RP EDF K+L Sbjct: 330 PPCLPTPGKREP--QGISWESPLDEVDKMCHL-PEPELNKERPSLQIKLKIEDFILHKML 386 Query: 62 GEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL-DHPFFVKLYF 120 G+GSF V LA T++ +AIK L+K ++ ++ V E+ V+S +HPF ++ Sbjct: 387 GKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFC 446 Query: 121 TFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK 180 TFQ E L+F + Y G+L+ +I+ FD + FY AEI+ L++LH KGI++RDLK Sbjct: 447 TFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLK 506 Query: 181 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA 240 +NILL++D HI+I DFG K A+ N+F GT Y++PE+L + S D W+ Sbjct: 507 LDNILLDKDGHIKIADFGMCK--ENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWS 564 Query: 241 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC 300 G ++Y+++ G PF +E +F I +P +A+DL+ KL V + KRLG Sbjct: 565 FGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGV 624 Query: 301 EEMEGYGPLKAHPFFESVTWENLHQQ 326 G ++ HP F + WE L ++ Sbjct: 625 R-----GDIRQHPLFREINWEELERK 645 >gi|4506067 protein kinase C, alpha [Homo sapiens] Length = 672 Score = 192 bits (487), Expect = 6e-49 Identities = 105/286 (36%), Positives = 164/286 (57%), Gaps = 4/286 (1%) Query: 42 QPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVT 101 QP + + DF F +LG+GSF V+LA T YAIKIL+K +I+++ V Sbjct: 326 QPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTM 385 Query: 102 RERDVMSRLDHP-FFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTA 160 E+ V++ LD P F +L+ FQ ++LYF + Y G+L+ +I+++G F E FY A Sbjct: 386 VEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAA 445 Query: 161 EIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQ 220 EI L +LH +GII+RDLK +N++L+ + HI+I DFG K + R +F GT Sbjct: 446 EISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTR--TFCGTPD 503 Query: 221 YVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFP 280 Y++PE++ + KS D WA G ++Y+++AG PPF +E +FQ I++ +P+ Sbjct: 504 YIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSK 563 Query: 281 KARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 326 +A + + L+ KRLGC EG ++ H FF + WE L + Sbjct: 564 EAVSICKGLMTKHPAKRLGCGP-EGERDVREHAFFRRIDWEKLENR 608 >gi|28557781 protein kinase C, eta [Homo sapiens] Length = 683 Score = 191 bits (486), Expect = 8e-49 Identities = 101/279 (36%), Positives = 163/279 (58%), Gaps = 4/279 (1%) Query: 53 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL-D 111 ++F+F ++LG+GSF V+LAR T YA+K+L+K I++++ V E+ ++S + Sbjct: 353 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 412 Query: 112 HPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHG 171 HPF +L+ FQ ++L+F + + G+L+ +I+K FDE RFY AEI+SAL +LH Sbjct: 413 HPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHD 472 Query: 172 KGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKS 231 KGII+RDLK +N+LL+ + H ++ DFG K +F GT Y++PE+L E Sbjct: 473 KGIIYRDLKLDNVLLDHEGHCKLADFGMCK--EGICNGVTTATFCGTPDYIAPEILQEML 530 Query: 232 ACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLV 291 + D WA+G ++Y+++ G PF A NE +F+ I+ E +P A +++ + Sbjct: 531 YGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT 590 Query: 292 LDATKRLGCEEMEGYGPLKAHPFFESVTWENL-HQQTPP 329 + T RLG G + HPFF+ + W L H+Q P Sbjct: 591 KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEP 629 >gi|4885563 protein kinase C, epsilon [Homo sapiens] Length = 737 Score = 191 bits (484), Expect = 1e-48 Identities = 101/283 (35%), Positives = 163/283 (57%), Gaps = 4/283 (1%) Query: 46 QPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERD 105 Q ++ ++F F K+LG+GSF V+LA YA+K+L+K I++++ V E+ Sbjct: 399 QAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKR 458 Query: 106 VMSRL-DHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVS 164 +++ HP+ +LY FQ ++L+F + Y G+L+ I++ FDE +RFY AE+ S Sbjct: 459 ILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTS 518 Query: 165 ALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSP 224 AL +LH G+I+RDLK +NILL+ + H ++ DFG K +F GT Y++P Sbjct: 519 ALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCK--EGILNGVTTTTFCGTPDYIAP 576 Query: 225 ELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARD 284 E+L E S D WALG ++Y+++AG PPF A NE +F+ I+ + +P +A Sbjct: 577 EILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVS 636 Query: 285 LVEKLLVLDATKRLGC-EEMEGYGPLKAHPFFESVTWENLHQQ 326 +++ + + KRLGC G +K HPFF+ + W L Q+ Sbjct: 637 ILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQK 679 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.319 0.137 0.425 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,773,817 Number of Sequences: 37866 Number of extensions: 925583 Number of successful extensions: 6588 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 773 Number of HSP's successfully gapped in prelim test: 93 Number of HSP's that attempted gapping in prelim test: 4036 Number of HSP's gapped (non-prelim): 1185 length of query: 396 length of database: 18,247,518 effective HSP length: 104 effective length of query: 292 effective length of database: 14,309,454 effective search space: 4178360568 effective search space used: 4178360568 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.