Guide to the Human Genome
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Search of human proteins with 239745384

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo
sapiens]
         (396 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo ...   817   0.0  
gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform...   710   0.0  
gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent ...   704   0.0  
gi|47680169 3-phosphoinositide dependent protein kinase-1 isofor...   289   3e-78
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H...   216   3e-56
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [...   216   3e-56
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [...   216   3e-56
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [...   216   3e-56
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ...   214   1e-55
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta...   214   1e-55
gi|4826948 protein kinase, X-linked [Homo sapiens]                    214   1e-55
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph...   211   9e-55
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha...   211   9e-55
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho...   207   1e-53
gi|4502023 AKT2 kinase [Homo sapiens]                                 202   4e-52
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho...   201   7e-52
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta...   201   1e-51
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph...   198   6e-51
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]                       197   1e-50
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]                      197   1e-50
gi|62241015 AKT1 kinase [Homo sapiens]                                197   1e-50
gi|62241013 AKT1 kinase [Homo sapiens]                                197   1e-50
gi|62241011 AKT1 kinase [Homo sapiens]                                197   1e-50
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   196   2e-50
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   196   2e-50
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho...   192   4e-49
gi|5453976 protein kinase C, theta [Homo sapiens]                     192   4e-49
gi|4506067 protein kinase C, alpha [Homo sapiens]                     192   6e-49
gi|28557781 protein kinase C, eta [Homo sapiens]                      191   8e-49
gi|4885563 protein kinase C, epsilon [Homo sapiens]                   191   1e-48

>gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo
           sapiens]
          Length = 396

 Score =  817 bits (2110), Expect = 0.0
 Identities = 396/396 (100%), Positives = 396/396 (100%)

Query: 1   MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 60
           MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI
Sbjct: 1   MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 60

Query: 61  LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF 120
           LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF
Sbjct: 61  LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF 120

Query: 121 TFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK 180
           TFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK
Sbjct: 121 TFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK 180

Query: 181 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA 240
           PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA
Sbjct: 181 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA 240

Query: 241 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC 300
           LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC
Sbjct: 241 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC 300

Query: 301 EEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNVSWPGWRARQVA 360
           EEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNVSWPGWRARQVA
Sbjct: 301 EEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNVSWPGWRARQVA 360

Query: 361 LGPPCTGLHARAPDPRVICSRKGRVSVPLRQACWWL 396
           LGPPCTGLHARAPDPRVICSRKGRVSVPLRQACWWL
Sbjct: 361 LGPPCTGLHARAPDPRVICSRKGRVSVPLRQACWWL 396


>gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform 1
           [Homo sapiens]
          Length = 556

 Score =  710 bits (1832), Expect = 0.0
 Identities = 348/348 (100%), Positives = 348/348 (100%)

Query: 1   MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 60
           MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI
Sbjct: 28  MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 87

Query: 61  LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF 120
           LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF
Sbjct: 88  LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF 147

Query: 121 TFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK 180
           TFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK
Sbjct: 148 TFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK 207

Query: 181 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA 240
           PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA
Sbjct: 208 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA 267

Query: 241 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC 300
           LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC
Sbjct: 268 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC 327

Query: 301 EEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGN 348
           EEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGN
Sbjct: 328 EEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGN 375


>gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent
           protein kinase-1 [Homo sapiens]
          Length = 471

 Score =  704 bits (1817), Expect = 0.0
 Identities = 351/371 (94%), Positives = 353/371 (95%), Gaps = 3/371 (0%)

Query: 1   MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 60
           MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI
Sbjct: 47  MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 106

Query: 61  LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF 120
           LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF
Sbjct: 107 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF 166

Query: 121 TFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK 180
           TFQ   +LYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK
Sbjct: 167 TFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK 226

Query: 181 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA 240
           PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA
Sbjct: 227 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA 286

Query: 241 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC 300
           LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC
Sbjct: 287 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC 346

Query: 301 EEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNVSWPGWRARQVA 360
           EEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGN +    R    A
Sbjct: 347 EEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNGAARTGRRAPPA 406

Query: 361 LGPPCTGLHAR 371
           L P   G H R
Sbjct: 407 LAP---GSHVR 414


>gi|47680169 3-phosphoinositide dependent protein kinase-1 isoform 2
           [Homo sapiens]
          Length = 429

 Score =  289 bits (739), Expect = 3e-78
 Identities = 138/138 (100%), Positives = 138/138 (100%)

Query: 211 RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL 270
           RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL
Sbjct: 111 RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL 170

Query: 271 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPK 330
           EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPK
Sbjct: 171 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPK 230

Query: 331 LTAYLPAMSEDDEDCYGN 348
           LTAYLPAMSEDDEDCYGN
Sbjct: 231 LTAYLPAMSEDDEDCYGN 248



 Score =  169 bits (429), Expect = 3e-42
 Identities = 82/84 (97%), Positives = 83/84 (98%)

Query: 1   MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 60
           MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI
Sbjct: 28  MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 87

Query: 61  LGEGSFSTVVLARELATSREYAIK 84
           LGEGSFSTVVLARELATSREYA +
Sbjct: 88  LGEGSFSTVVLARELATSREYATR 111


>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
           sapiens]
          Length = 431

 Score =  216 bits (550), Expect = 3e-56
 Identities = 120/313 (38%), Positives = 180/313 (57%), Gaps = 8/313 (2%)

Query: 20  QGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSR 79
           Q P +      P P      +  P   P  K P DF F K++G+GSF  V+LAR  A   
Sbjct: 64  QEPELMNANPSPPPSPSQQINLGPSSNPHAK-PSDFHFLKVIGKGSFGKVLLARHKAEEV 122

Query: 80  EYAIKILEKRHIIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQDDEKLYFGLSYAKNG 138
            YA+K+L+K+ I+K+ +  ++  ER+V+ + + HPF V L+F+FQ  +KLYF L Y   G
Sbjct: 123 FYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGG 182

Query: 139 ELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG 198
           EL  ++++   F E   RFY AEI SAL YLH   I++RDLKPENILL+   HI +TDFG
Sbjct: 183 ELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG 242

Query: 199 TAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAG 258
             K        +  ++F GT +Y++PE+L ++   ++ D W LG ++Y+++ GLPPF + 
Sbjct: 243 LCK--ENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR 300

Query: 259 NEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESV 318
           N   ++  I+             AR L+E LL  D TKRLG +  + +  +K+H FF  +
Sbjct: 301 NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAK--DDFMEIKSHVFFSLI 358

Query: 319 TWENLHQQ--TPP 329
            W++L  +  TPP
Sbjct: 359 NWDDLINKKITPP 371


>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
           [Homo sapiens]
          Length = 445

 Score =  216 bits (550), Expect = 3e-56
 Identities = 120/313 (38%), Positives = 180/313 (57%), Gaps = 8/313 (2%)

Query: 20  QGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSR 79
           Q P +      P P      +  P   P  K P DF F K++G+GSF  V+LAR  A   
Sbjct: 78  QEPELMNANPSPPPSPSQQINLGPSSNPHAK-PSDFHFLKVIGKGSFGKVLLARHKAEEV 136

Query: 80  EYAIKILEKRHIIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQDDEKLYFGLSYAKNG 138
            YA+K+L+K+ I+K+ +  ++  ER+V+ + + HPF V L+F+FQ  +KLYF L Y   G
Sbjct: 137 FYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGG 196

Query: 139 ELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG 198
           EL  ++++   F E   RFY AEI SAL YLH   I++RDLKPENILL+   HI +TDFG
Sbjct: 197 ELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG 256

Query: 199 TAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAG 258
             K        +  ++F GT +Y++PE+L ++   ++ D W LG ++Y+++ GLPPF + 
Sbjct: 257 LCK--ENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR 314

Query: 259 NEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESV 318
           N   ++  I+             AR L+E LL  D TKRLG +  + +  +K+H FF  +
Sbjct: 315 NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAK--DDFMEIKSHVFFSLI 372

Query: 319 TWENLHQQ--TPP 329
            W++L  +  TPP
Sbjct: 373 NWDDLINKKITPP 385


>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
           [Homo sapiens]
          Length = 459

 Score =  216 bits (550), Expect = 3e-56
 Identities = 120/313 (38%), Positives = 180/313 (57%), Gaps = 8/313 (2%)

Query: 20  QGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSR 79
           Q P +      P P      +  P   P  K P DF F K++G+GSF  V+LAR  A   
Sbjct: 92  QEPELMNANPSPPPSPSQQINLGPSSNPHAK-PSDFHFLKVIGKGSFGKVLLARHKAEEV 150

Query: 80  EYAIKILEKRHIIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQDDEKLYFGLSYAKNG 138
            YA+K+L+K+ I+K+ +  ++  ER+V+ + + HPF V L+F+FQ  +KLYF L Y   G
Sbjct: 151 FYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGG 210

Query: 139 ELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG 198
           EL  ++++   F E   RFY AEI SAL YLH   I++RDLKPENILL+   HI +TDFG
Sbjct: 211 ELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG 270

Query: 199 TAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAG 258
             K        +  ++F GT +Y++PE+L ++   ++ D W LG ++Y+++ GLPPF + 
Sbjct: 271 LCK--ENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR 328

Query: 259 NEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESV 318
           N   ++  I+             AR L+E LL  D TKRLG +  + +  +K+H FF  +
Sbjct: 329 NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAK--DDFMEIKSHVFFSLI 386

Query: 319 TWENLHQQ--TPP 329
            W++L  +  TPP
Sbjct: 387 NWDDLINKKITPP 399


>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
           [Homo sapiens]
          Length = 526

 Score =  216 bits (550), Expect = 3e-56
 Identities = 120/313 (38%), Positives = 180/313 (57%), Gaps = 8/313 (2%)

Query: 20  QGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSR 79
           Q P +      P P      +  P   P  K P DF F K++G+GSF  V+LAR  A   
Sbjct: 159 QEPELMNANPSPPPSPSQQINLGPSSNPHAK-PSDFHFLKVIGKGSFGKVLLARHKAEEV 217

Query: 80  EYAIKILEKRHIIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQDDEKLYFGLSYAKNG 138
            YA+K+L+K+ I+K+ +  ++  ER+V+ + + HPF V L+F+FQ  +KLYF L Y   G
Sbjct: 218 FYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGG 277

Query: 139 ELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG 198
           EL  ++++   F E   RFY AEI SAL YLH   I++RDLKPENILL+   HI +TDFG
Sbjct: 278 ELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG 337

Query: 199 TAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAG 258
             K        +  ++F GT +Y++PE+L ++   ++ D W LG ++Y+++ GLPPF + 
Sbjct: 338 LCK--ENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR 395

Query: 259 NEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESV 318
           N   ++  I+             AR L+E LL  D TKRLG +  + +  +K+H FF  +
Sbjct: 396 NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAK--DDFMEIKSHVFFSLI 453

Query: 319 TWENLHQQ--TPP 329
            W++L  +  TPP
Sbjct: 454 NWDDLINKKITPP 466


>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
           isoform 2 [Homo sapiens]
          Length = 351

 Score =  214 bits (545), Expect = 1e-55
 Identities = 106/274 (38%), Positives = 165/274 (60%), Gaps = 6/274 (2%)

Query: 53  EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 112
           EDF+  K LG GSF  V+L +  AT + YA+KIL+K+ ++K  ++ +   E+ ++  ++ 
Sbjct: 42  EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101

Query: 113 PFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 172
           PF V+L + F+D+  LY  + Y   GE+  ++R+IG F E   RFY A+IV   EYLH  
Sbjct: 102 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161

Query: 173 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSA 232
            +I+RDLKPEN+L++   +IQ+TDFG AK +     + R  +  GT +Y++PE++  K  
Sbjct: 162 DLIYRDLKPENLLIDHQGYIQVTDFGFAKRV-----KGRTWTLCGTPEYLAPEIILSKGY 216

Query: 233 CKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 292
            K+ D WALG +IY++ AG PPF A     I++KI+  +  FP  F    +DL+  LL +
Sbjct: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 276

Query: 293 DATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 326
           D TKR G     G   +K H +F +  W  ++Q+
Sbjct: 277 DLTKRFG-NLKNGVSDIKTHKWFATTDWIAIYQR 309


>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
           isoform 1 [Homo sapiens]
          Length = 398

 Score =  214 bits (545), Expect = 1e-55
 Identities = 106/274 (38%), Positives = 165/274 (60%), Gaps = 6/274 (2%)

Query: 53  EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 112
           EDF+  K LG GSF  V+L +  AT + YA+KIL+K+ ++K  ++ +   E+ ++  ++ 
Sbjct: 89  EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 148

Query: 113 PFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 172
           PF V+L + F+D+  LY  + Y   GE+  ++R+IG F E   RFY A+IV   EYLH  
Sbjct: 149 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 208

Query: 173 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSA 232
            +I+RDLKPEN+L++   +IQ+TDFG AK +     + R  +  GT +Y++PE++  K  
Sbjct: 209 DLIYRDLKPENLLIDHQGYIQVTDFGFAKRV-----KGRTWTLCGTPEYLAPEIILSKGY 263

Query: 233 CKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 292
            K+ D WALG +IY++ AG PPF A     I++KI+  +  FP  F    +DL+  LL +
Sbjct: 264 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 323

Query: 293 DATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 326
           D TKR G     G   +K H +F +  W  ++Q+
Sbjct: 324 DLTKRFG-NLKNGVSDIKTHKWFATTDWIAIYQR 356


>gi|4826948 protein kinase, X-linked [Homo sapiens]
          Length = 358

 Score =  214 bits (545), Expect = 1e-55
 Identities = 110/282 (39%), Positives = 169/282 (59%), Gaps = 6/282 (2%)

Query: 45  PQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRER 104
           P+P     +DF     +G G+F  V L +E      +A+K++    +I+  +  +V  E+
Sbjct: 39  PEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEK 98

Query: 105 DVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVS 164
            V+  + HPF ++L++T+ D+  LY  + Y   GEL  Y+R  G F  T   FY+AEI+ 
Sbjct: 99  SVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIIC 158

Query: 165 ALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSP 224
           A+EYLH K I++RDLKPENILL+ D HI++TDFG AK L       R  +  GT +Y++P
Sbjct: 159 AIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVD-----RTWTLCGTPEYLAP 213

Query: 225 ELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARD 284
           E++  K   ++ D WALG +I+++++G PPF   N + I+QKI+  + DFP       +D
Sbjct: 214 EVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKD 273

Query: 285 LVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 326
           L++KLLV+D T+RLG     G   +K H +F SV WE + Q+
Sbjct: 274 LIKKLLVVDRTRRLG-NMKNGANDVKHHRWFRSVDWEAVPQR 314


>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
           isoform 2 [Homo sapiens]
          Length = 343

 Score =  211 bits (537), Expect = 9e-55
 Identities = 105/274 (38%), Positives = 164/274 (59%), Gaps = 6/274 (2%)

Query: 53  EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 112
           + F+  K LG GSF  V+L +   T   YA+KIL+K+ ++K  ++ +   E+ ++  ++ 
Sbjct: 34  DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 93

Query: 113 PFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 172
           PF VKL F+F+D+  LY  + Y   GE+  ++R+IG F E   RFY A+IV   EYLH  
Sbjct: 94  PFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 153

Query: 173 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSA 232
            +I+RDLKPEN+L+++  +IQ+TDFG AK +     + R  +  GT +Y++PE++  K  
Sbjct: 154 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-----KGRTWTLCGTPEYLAPEIILSKGY 208

Query: 233 CKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 292
            K+ D WALG +IY++ AG PPF A     I++KI+  +  FP  F    +DL+  LL +
Sbjct: 209 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 268

Query: 293 DATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 326
           D TKR G     G   +K H +F +  W  ++Q+
Sbjct: 269 DLTKRFG-NLKNGVNDIKNHKWFATTDWIAIYQR 301


>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
           isoform 1 [Homo sapiens]
          Length = 351

 Score =  211 bits (537), Expect = 9e-55
 Identities = 105/274 (38%), Positives = 164/274 (59%), Gaps = 6/274 (2%)

Query: 53  EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 112
           + F+  K LG GSF  V+L +   T   YA+KIL+K+ ++K  ++ +   E+ ++  ++ 
Sbjct: 42  DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101

Query: 113 PFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 172
           PF VKL F+F+D+  LY  + Y   GE+  ++R+IG F E   RFY A+IV   EYLH  
Sbjct: 102 PFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161

Query: 173 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSA 232
            +I+RDLKPEN+L+++  +IQ+TDFG AK +     + R  +  GT +Y++PE++  K  
Sbjct: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-----KGRTWTLCGTPEYLAPEIILSKGY 216

Query: 233 CKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 292
            K+ D WALG +IY++ AG PPF A     I++KI+  +  FP  F    +DL+  LL +
Sbjct: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 276

Query: 293 DATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 326
           D TKR G     G   +K H +F +  W  ++Q+
Sbjct: 277 DLTKRFG-NLKNGVNDIKNHKWFATTDWIAIYQR 309


>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
           sapiens]
          Length = 351

 Score =  207 bits (528), Expect = 1e-53
 Identities = 108/303 (35%), Positives = 171/303 (56%), Gaps = 11/303 (3%)

Query: 45  PQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRER 104
           P       + F+  + LG GSF  V+L R   T   YA+KIL K+ ++K  +V ++  E+
Sbjct: 34  PAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEK 93

Query: 105 DVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVS 164
            ++  +D PF VKL F+F+D+  LY  + Y   GE+   ++++G F E    FY A++V 
Sbjct: 94  RILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVL 153

Query: 165 ALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSP 224
           A++YLH   +IHRDLKPEN+L+++  ++Q+TDFG AK +     + R  +  GT +Y++P
Sbjct: 154 AVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRV-----KGRTWTLCGTPEYLAP 208

Query: 225 ELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARD 284
           E++  K   K+ D WALG +IY++  G PPF A     I++KI+     FP K     + 
Sbjct: 209 EIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKH 268

Query: 285 LVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTP-----PKLTAYLPAMS 339
           L+  LL +D TKR G     G G +K H +F + +W  ++++       PK T    A +
Sbjct: 269 LLRSLLQVDLTKRFG-NLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASN 327

Query: 340 EDD 342
            DD
Sbjct: 328 FDD 330


>gi|4502023 AKT2 kinase [Homo sapiens]
          Length = 481

 Score =  202 bits (514), Expect = 4e-52
 Identities = 125/369 (33%), Positives = 193/369 (52%), Gaps = 25/369 (6%)

Query: 1   MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 60
           MV    +   P   P   + G   D +  E    A S   A       K    DF + K+
Sbjct: 105 MVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARA-------KVTMNDFDYLKL 157

Query: 61  LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF 120
           LG+G+F  V+L RE AT R YA+KIL K  II +++V +   E  V+    HPF   L +
Sbjct: 158 LGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKY 217

Query: 121 TFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK 180
            FQ  ++L F + YA  GEL  ++ +   F E   RFY AEIVSALEYLH + +++RD+K
Sbjct: 218 AFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIK 277

Query: 181 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA 240
            EN++L++D HI+ITDFG  K     S  A   +F GT +Y++PE+L +    ++ D W 
Sbjct: 278 LENLMLDKDGHIKITDFGLCK--EGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWG 335

Query: 241 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC 300
           LG ++Y+++ G  PF   +   +F+ I+  E  FP    P+A+ L+  LL  D  +RLG 
Sbjct: 336 LGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGG 395

Query: 301 EEMEGYGPLKAHPFFESVTWENLHQQT-----PPKLTAYLPAMSEDDEDCYGNVSWPGWR 355
              +    ++ H FF S+ W+++ Q+       P++T+ +     DDE          + 
Sbjct: 396 GPSDAKEVME-HRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDE----------FT 444

Query: 356 ARQVALGPP 364
           A+ + + PP
Sbjct: 445 AQSITITPP 453


>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
           sapiens]
          Length = 525

 Score =  201 bits (512), Expect = 7e-52
 Identities = 108/281 (38%), Positives = 161/281 (57%), Gaps = 7/281 (2%)

Query: 47  PRKKRPEDFKFGKILGEGSFSTVVLARELA---TSREYAIKILEKRHIIKENK-VPYVTR 102
           P K RPE F+  ++LG+G +  V   R++    T + +A+K+L+K  I++  K   +   
Sbjct: 83  PEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKA 142

Query: 103 ERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEI 162
           ER+++  + HPF V L + FQ   KLY  L Y   GEL   + + G F E    FY AEI
Sbjct: 143 ERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEI 202

Query: 163 VSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYV 222
             AL +LH KGII+RDLKPENI+LN   H+++TDFG  K    +      ++F GT +Y+
Sbjct: 203 SMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDG--TVTHTFCGTIEYM 260

Query: 223 SPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKA 282
           +PE+L      ++ D W+LG ++Y ++ G PPF   N      KI+K + + P     +A
Sbjct: 261 APEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEA 320

Query: 283 RDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENL 323
           RDL++KLL  +A  RLG    +  G ++AHPFF  + WE L
Sbjct: 321 RDLLKKLLKRNAASRLGAGPGDA-GEVQAHPFFRHINWEEL 360


>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
           [Homo sapiens]
          Length = 427

 Score =  201 bits (511), Expect = 1e-51
 Identities = 112/323 (34%), Positives = 183/323 (56%), Gaps = 9/323 (2%)

Query: 11  PPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVV 70
           PP +P    +  +       P+P   +      P      +P DF F K++G+G++  V+
Sbjct: 51  PPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVL 110

Query: 71  LARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQDDEKLY 129
           LA+  +    YA+K+L+K+ I+K+ +  ++  ER V+ + + HPF V L ++FQ  EKLY
Sbjct: 111 LAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLY 170

Query: 130 FGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNED 189
           F L Y   GEL  ++++   F E   RFY AE+ SA+ YLH   II+RDLKPENILL+  
Sbjct: 171 FVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQ 230

Query: 190 MHIQITDFGTAKV-LSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQL 248
            H+ +TDFG  K  + PE      ++F GT +Y++PE+L ++   ++ D W LG ++Y++
Sbjct: 231 GHVVLTDFGLCKEGVEPED---TTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEM 287

Query: 249 VAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGP 308
           + GLPPF + +   +++ I+      P      A DL++ LL  D  +RLG +    +  
Sbjct: 288 LHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSK--ADFLE 345

Query: 309 LKAHPFFESVTWENLHQQ--TPP 329
           +K H FF  + W++L+ +  TPP
Sbjct: 346 IKNHVFFSPINWDDLYHKRLTPP 368


>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
           [Homo sapiens]
          Length = 367

 Score =  198 bits (504), Expect = 6e-51
 Identities = 109/303 (35%), Positives = 177/303 (58%), Gaps = 9/303 (2%)

Query: 31  PRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRH 90
           P+P   +      P      +P DF F K++G+G++  V+LA+  +    YA+K+L+K+ 
Sbjct: 11  PQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKS 70

Query: 91  IIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGS 149
           I+K+ +  ++  ER V+ + + HPF V L ++FQ  EKLYF L Y   GEL  ++++   
Sbjct: 71  ILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERR 130

Query: 150 FDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKV-LSPESK 208
           F E   RFY AE+ SA+ YLH   II+RDLKPENILL+   H+ +TDFG  K  + PE  
Sbjct: 131 FLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPED- 189

Query: 209 QARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKII 268
               ++F GT +Y++PE+L ++   ++ D W LG ++Y+++ GLPPF + +   +++ I+
Sbjct: 190 --TTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENIL 247

Query: 269 KLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ-- 326
                 P      A DL++ LL  D  +RLG +    +  +K H FF  + W++L+ +  
Sbjct: 248 HQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSK--ADFLEIKNHVFFSPINWDDLYHKRL 305

Query: 327 TPP 329
           TPP
Sbjct: 306 TPP 308


>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
          Length = 479

 Score =  197 bits (501), Expect = 1e-50
 Identities = 110/319 (34%), Positives = 181/319 (56%), Gaps = 12/319 (3%)

Query: 48  RKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVM 107
           ++K   DF + K+LG+G+F  V+L RE A+ + YA+KIL+K  II +++V +   E  V+
Sbjct: 141 KRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL 200

Query: 108 SRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALE 167
               HPF   L ++FQ  ++L F + Y   GEL  ++ +   F E  TRFY AEIVSAL+
Sbjct: 201 KNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALD 260

Query: 168 YLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELL 227
           YLH   I++RDLK EN++L++D HI+ITDFG  K     +  A   +F GT +Y++PE+L
Sbjct: 261 YLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCK--EGITDAATMKTFCGTPEYLAPEVL 318

Query: 228 TEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVE 287
            +    ++ D W LG ++Y+++ G  PF   +   +F+ I+  +  FP      A+ L+ 
Sbjct: 319 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLS 378

Query: 288 KLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ--TPPKLTAYLPAMSEDDEDC 345
            LL+ D  KRLG    +    +  H FF  V W++++ +   PP    + P ++ + +  
Sbjct: 379 GLLIKDPNKRLG-GGPDDAKEIMRHSFFSGVNWQDVYDKKLVPP----FKPQVTSETDTR 433

Query: 346 YGNVSWPGWRARQVALGPP 364
           Y +     + A+ + + PP
Sbjct: 434 YFDEE---FTAQTITITPP 449


>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
          Length = 465

 Score =  197 bits (501), Expect = 1e-50
 Identities = 110/319 (34%), Positives = 181/319 (56%), Gaps = 12/319 (3%)

Query: 48  RKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVM 107
           ++K   DF + K+LG+G+F  V+L RE A+ + YA+KIL+K  II +++V +   E  V+
Sbjct: 141 KRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL 200

Query: 108 SRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALE 167
               HPF   L ++FQ  ++L F + Y   GEL  ++ +   F E  TRFY AEIVSAL+
Sbjct: 201 KNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALD 260

Query: 168 YLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELL 227
           YLH   I++RDLK EN++L++D HI+ITDFG  K     +  A   +F GT +Y++PE+L
Sbjct: 261 YLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCK--EGITDAATMKTFCGTPEYLAPEVL 318

Query: 228 TEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVE 287
            +    ++ D W LG ++Y+++ G  PF   +   +F+ I+  +  FP      A+ L+ 
Sbjct: 319 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLS 378

Query: 288 KLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ--TPPKLTAYLPAMSEDDEDC 345
            LL+ D  KRLG    +    +  H FF  V W++++ +   PP    + P ++ + +  
Sbjct: 379 GLLIKDPNKRLG-GGPDDAKEIMRHSFFSGVNWQDVYDKKLVPP----FKPQVTSETDTR 433

Query: 346 YGNVSWPGWRARQVALGPP 364
           Y +     + A+ + + PP
Sbjct: 434 YFDEE---FTAQTITITPP 449


>gi|62241015 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  197 bits (501), Expect = 1e-50
 Identities = 114/345 (33%), Positives = 195/345 (56%), Gaps = 14/345 (4%)

Query: 24  MDGTAAEPRPGAGSLQHAQPPPQPRKK-RPEDFKFGKILGEGSFSTVVLARELATSREYA 82
           MD  +  P   +G+ +      +P+ +    +F++ K+LG+G+F  V+L +E AT R YA
Sbjct: 118 MDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYA 177

Query: 83  IKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLK 142
           +KIL+K  I+ +++V +   E  V+    HPF   L ++FQ  ++L F + YA  GEL  
Sbjct: 178 MKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFF 237

Query: 143 YIRKIGSFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENILLNEDMHIQITDFGTAK 201
           ++ +   F E   RFY AEIVSAL+YLH  K +++RDLK EN++L++D HI+ITDFG  K
Sbjct: 238 HLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK 297

Query: 202 VLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEY 261
               +   A   +F GT +Y++PE+L +    ++ D W LG ++Y+++ G  PF   +  
Sbjct: 298 EGIKDG--ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE 355

Query: 262 LIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWE 321
            +F+ I+  E  FP    P+A+ L+  LL  D  +RLG    E    +  H FF  + W+
Sbjct: 356 KLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG-GGSEDAKEIMQHRFFAGIVWQ 414

Query: 322 NLHQQ--TPPKLTAYLPAMSEDDEDCYGNVSWPGWRARQVALGPP 364
           +++++  +PP    + P ++ + +  Y +     + A+ + + PP
Sbjct: 415 HVYEKKLSPP----FKPQVTSETDTRYFDEE---FTAQMITITPP 452


>gi|62241013 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  197 bits (501), Expect = 1e-50
 Identities = 114/345 (33%), Positives = 195/345 (56%), Gaps = 14/345 (4%)

Query: 24  MDGTAAEPRPGAGSLQHAQPPPQPRKK-RPEDFKFGKILGEGSFSTVVLARELATSREYA 82
           MD  +  P   +G+ +      +P+ +    +F++ K+LG+G+F  V+L +E AT R YA
Sbjct: 118 MDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYA 177

Query: 83  IKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLK 142
           +KIL+K  I+ +++V +   E  V+    HPF   L ++FQ  ++L F + YA  GEL  
Sbjct: 178 MKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFF 237

Query: 143 YIRKIGSFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENILLNEDMHIQITDFGTAK 201
           ++ +   F E   RFY AEIVSAL+YLH  K +++RDLK EN++L++D HI+ITDFG  K
Sbjct: 238 HLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK 297

Query: 202 VLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEY 261
               +   A   +F GT +Y++PE+L +    ++ D W LG ++Y+++ G  PF   +  
Sbjct: 298 EGIKDG--ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE 355

Query: 262 LIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWE 321
            +F+ I+  E  FP    P+A+ L+  LL  D  +RLG    E    +  H FF  + W+
Sbjct: 356 KLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG-GGSEDAKEIMQHRFFAGIVWQ 414

Query: 322 NLHQQ--TPPKLTAYLPAMSEDDEDCYGNVSWPGWRARQVALGPP 364
           +++++  +PP    + P ++ + +  Y +     + A+ + + PP
Sbjct: 415 HVYEKKLSPP----FKPQVTSETDTRYFDEE---FTAQMITITPP 452


>gi|62241011 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  197 bits (501), Expect = 1e-50
 Identities = 114/345 (33%), Positives = 195/345 (56%), Gaps = 14/345 (4%)

Query: 24  MDGTAAEPRPGAGSLQHAQPPPQPRKK-RPEDFKFGKILGEGSFSTVVLARELATSREYA 82
           MD  +  P   +G+ +      +P+ +    +F++ K+LG+G+F  V+L +E AT R YA
Sbjct: 118 MDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYA 177

Query: 83  IKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLK 142
           +KIL+K  I+ +++V +   E  V+    HPF   L ++FQ  ++L F + YA  GEL  
Sbjct: 178 MKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFF 237

Query: 143 YIRKIGSFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENILLNEDMHIQITDFGTAK 201
           ++ +   F E   RFY AEIVSAL+YLH  K +++RDLK EN++L++D HI+ITDFG  K
Sbjct: 238 HLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK 297

Query: 202 VLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEY 261
               +   A   +F GT +Y++PE+L +    ++ D W LG ++Y+++ G  PF   +  
Sbjct: 298 EGIKDG--ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE 355

Query: 262 LIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWE 321
            +F+ I+  E  FP    P+A+ L+  LL  D  +RLG    E    +  H FF  + W+
Sbjct: 356 KLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG-GGSEDAKEIMQHRFFAGIVWQ 414

Query: 322 NLHQQ--TPPKLTAYLPAMSEDDEDCYGNVSWPGWRARQVALGPP 364
           +++++  +PP    + P ++ + +  Y +     + A+ + + PP
Sbjct: 415 HVYEKKLSPP----FKPQVTSETDTRYFDEE---FTAQMITITPP 452


>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  196 bits (499), Expect = 2e-50
 Identities = 107/288 (37%), Positives = 169/288 (58%), Gaps = 6/288 (2%)

Query: 43  PPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTR 102
           P   P  K P DF F K++G+GSF  V+LA+     + YA+K+L+K+ ++   +  ++  
Sbjct: 151 PSGNPHAK-PTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMA 209

Query: 103 ERDVMSR-LDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAE 161
           ER+V+ + + HPF V L+++FQ  EKLYF L +   GEL  ++++  SF E   RFY AE
Sbjct: 210 ERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAE 269

Query: 162 IVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQY 221
           I SAL YLH   I++RDLKPENILL+   H+ +TDFG  K     +      +F GT +Y
Sbjct: 270 IASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCK--EGIAISDTTTTFCGTPEY 327

Query: 222 VSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPK 281
           ++PE++ ++    + D W LG ++Y+++ GLPPF   +   ++  I+             
Sbjct: 328 LAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLT 387

Query: 282 ARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPP 329
           A  ++E+LL  D   RLG +  E +  ++ HPFFES++W +L Q+  P
Sbjct: 388 AWSILEELLEKDRQNRLGAK--EDFLEIQNHPFFESLSWADLVQKKIP 433


>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  196 bits (499), Expect = 2e-50
 Identities = 107/288 (37%), Positives = 169/288 (58%), Gaps = 6/288 (2%)

Query: 43  PPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTR 102
           P   P  K P DF F K++G+GSF  V+LA+     + YA+K+L+K+ ++   +  ++  
Sbjct: 151 PSGNPHAK-PTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMA 209

Query: 103 ERDVMSR-LDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAE 161
           ER+V+ + + HPF V L+++FQ  EKLYF L +   GEL  ++++  SF E   RFY AE
Sbjct: 210 ERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAE 269

Query: 162 IVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQY 221
           I SAL YLH   I++RDLKPENILL+   H+ +TDFG  K     +      +F GT +Y
Sbjct: 270 IASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCK--EGIAISDTTTTFCGTPEY 327

Query: 222 VSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPK 281
           ++PE++ ++    + D W LG ++Y+++ GLPPF   +   ++  I+             
Sbjct: 328 LAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLT 387

Query: 282 ARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPP 329
           A  ++E+LL  D   RLG +  E +  ++ HPFFES++W +L Q+  P
Sbjct: 388 AWSILEELLEKDRQNRLGAK--EDFLEIQNHPFFESLSWADLVQKKIP 433


>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
           sapiens]
          Length = 740

 Score =  192 bits (488), Expect = 4e-49
 Identities = 108/326 (33%), Positives = 181/326 (55%), Gaps = 13/326 (3%)

Query: 49  KKRPEDFKFGKILGEGSFSTVVLARELATS---REYAIKILEKRHIIKENKVPYVTRERD 105
           K  P  F+  K+LG+GSF  V L ++++ S   + YA+K+L+K  +   ++V     ERD
Sbjct: 62  KADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVR-TKMERD 120

Query: 106 VMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSA 165
           ++  ++HPF VKL++ FQ + KLY  L + + G+L   + K   F E   +FY AE+  A
Sbjct: 121 ILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 180

Query: 166 LEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPE 225
           L++LH  GII+RDLKPENILL+E+ HI++TDFG +K      K  +A SF GT +Y++PE
Sbjct: 181 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEK--KAYSFCGTVEYMAPE 238

Query: 226 LLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDL 285
           ++  +   +S+D W+ G ++++++ G  PF+  +       I+K +   P+   P+A+ L
Sbjct: 239 VVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSL 298

Query: 286 VEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQT--PPKLTAYLPAMSEDDE 343
           +  L   +   RLG    +G   +K H FF ++ W  L+++   PP    + PA    ++
Sbjct: 299 LRMLFKRNPANRLGAGP-DGVEEIKRHSFFSTIDWNKLYRREIHPP----FKPATGRPED 353

Query: 344 DCYGNVSWPGWRARQVALGPPCTGLH 369
             Y +  +     +     PP    H
Sbjct: 354 TFYFDPEFTAKTPKDSPGIPPSANAH 379



 Score =  108 bits (270), Expect = 8e-24
 Identities = 85/277 (30%), Positives = 131/277 (47%), Gaps = 29/277 (10%)

Query: 61  LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL-DHPFFVKLY 119
           +G GS+S        AT+ E+A+KI++K       + P  T E +++ R   HP  + L 
Sbjct: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDK-----SKRDP--TEEIEILLRYGQHPNIITLK 480

Query: 120 FTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDL 179
             + D + +Y      K GELL  I +   F E         I   +EYLH +G++HRDL
Sbjct: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540

Query: 180 KPENILLNEDM----HIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKS 235
           KP NIL  ++      I+I DFG AK L  E+       +  TA +V+PE+L  +    +
Sbjct: 541 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCY--TANFVAPEVLKRQGYDAA 598

Query: 236 SDLWALGCIIYQLVAGLPPFRAGNEYL---IFQKI----IKLEYDFPEKFFPKARDLVEK 288
            D+W+LG ++Y ++ G  PF  G +     I  +I      L   +       A+DLV K
Sbjct: 599 CDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSK 658

Query: 289 LLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQ 325
           +L +D  +RL          +  HP+   V W+ L Q
Sbjct: 659 MLHVDPHQRLTA------ALVLRHPWI--VHWDQLPQ 687


>gi|5453976 protein kinase C, theta [Homo sapiens]
          Length = 706

 Score =  192 bits (488), Expect = 4e-49
 Identities = 115/326 (35%), Positives = 177/326 (54%), Gaps = 20/326 (6%)

Query: 11  PPGIPGGSRQGPAMDGTAAE-PRPGAGSLQHAQPPPQPRKKRP--------EDFKFGKIL 61
           PP +P   ++ P   G + E P      + H  P P+  K+RP        EDF   K+L
Sbjct: 330 PPCLPTPGKREP--QGISWESPLDEVDKMCHL-PEPELNKERPSLQIKLKIEDFILHKML 386

Query: 62  GEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL-DHPFFVKLYF 120
           G+GSF  V LA    T++ +AIK L+K  ++ ++ V     E+ V+S   +HPF   ++ 
Sbjct: 387 GKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFC 446

Query: 121 TFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK 180
           TFQ  E L+F + Y   G+L+ +I+    FD +   FY AEI+  L++LH KGI++RDLK
Sbjct: 447 TFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLK 506

Query: 181 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA 240
            +NILL++D HI+I DFG  K        A+ N+F GT  Y++PE+L  +    S D W+
Sbjct: 507 LDNILLDKDGHIKIADFGMCK--ENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWS 564

Query: 241 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC 300
            G ++Y+++ G  PF   +E  +F  I      +P     +A+DL+ KL V +  KRLG 
Sbjct: 565 FGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGV 624

Query: 301 EEMEGYGPLKAHPFFESVTWENLHQQ 326
                 G ++ HP F  + WE L ++
Sbjct: 625 R-----GDIRQHPLFREINWEELERK 645


>gi|4506067 protein kinase C, alpha [Homo sapiens]
          Length = 672

 Score =  192 bits (487), Expect = 6e-49
 Identities = 105/286 (36%), Positives = 164/286 (57%), Gaps = 4/286 (1%)

Query: 42  QPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVT 101
           QP     + +  DF F  +LG+GSF  V+LA    T   YAIKIL+K  +I+++ V    
Sbjct: 326 QPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTM 385

Query: 102 RERDVMSRLDHP-FFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTA 160
            E+ V++ LD P F  +L+  FQ  ++LYF + Y   G+L+ +I+++G F E    FY A
Sbjct: 386 VEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAA 445

Query: 161 EIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQ 220
           EI   L +LH +GII+RDLK +N++L+ + HI+I DFG  K    +    R  +F GT  
Sbjct: 446 EISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTR--TFCGTPD 503

Query: 221 YVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFP 280
           Y++PE++  +   KS D WA G ++Y+++AG PPF   +E  +FQ I++    +P+    
Sbjct: 504 YIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSK 563

Query: 281 KARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 326
           +A  + + L+     KRLGC   EG   ++ H FF  + WE L  +
Sbjct: 564 EAVSICKGLMTKHPAKRLGCGP-EGERDVREHAFFRRIDWEKLENR 608


>gi|28557781 protein kinase C, eta [Homo sapiens]
          Length = 683

 Score =  191 bits (486), Expect = 8e-49
 Identities = 101/279 (36%), Positives = 163/279 (58%), Gaps = 4/279 (1%)

Query: 53  EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL-D 111
           ++F+F ++LG+GSF  V+LAR   T   YA+K+L+K  I++++ V     E+ ++S   +
Sbjct: 353 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 412

Query: 112 HPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHG 171
           HPF  +L+  FQ  ++L+F + +   G+L+ +I+K   FDE   RFY AEI+SAL +LH 
Sbjct: 413 HPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHD 472

Query: 172 KGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKS 231
           KGII+RDLK +N+LL+ + H ++ DFG  K            +F GT  Y++PE+L E  
Sbjct: 473 KGIIYRDLKLDNVLLDHEGHCKLADFGMCK--EGICNGVTTATFCGTPDYIAPEILQEML 530

Query: 232 ACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLV 291
              + D WA+G ++Y+++ G  PF A NE  +F+ I+  E  +P      A  +++  + 
Sbjct: 531 YGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT 590

Query: 292 LDATKRLGCEEMEGYGPLKAHPFFESVTWENL-HQQTPP 329
            + T RLG     G   +  HPFF+ + W  L H+Q  P
Sbjct: 591 KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEP 629


>gi|4885563 protein kinase C, epsilon [Homo sapiens]
          Length = 737

 Score =  191 bits (484), Expect = 1e-48
 Identities = 101/283 (35%), Positives = 163/283 (57%), Gaps = 4/283 (1%)

Query: 46  QPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERD 105
           Q ++   ++F F K+LG+GSF  V+LA        YA+K+L+K  I++++ V     E+ 
Sbjct: 399 QAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKR 458

Query: 106 VMSRL-DHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVS 164
           +++    HP+  +LY  FQ  ++L+F + Y   G+L+  I++   FDE  +RFY AE+ S
Sbjct: 459 ILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTS 518

Query: 165 ALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSP 224
           AL +LH  G+I+RDLK +NILL+ + H ++ DFG  K            +F GT  Y++P
Sbjct: 519 ALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCK--EGILNGVTTTTFCGTPDYIAP 576

Query: 225 ELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARD 284
           E+L E     S D WALG ++Y+++AG PPF A NE  +F+ I+  +  +P     +A  
Sbjct: 577 EILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVS 636

Query: 285 LVEKLLVLDATKRLGC-EEMEGYGPLKAHPFFESVTWENLHQQ 326
           +++  +  +  KRLGC     G   +K HPFF+ + W  L Q+
Sbjct: 637 ILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQK 679


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.137    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,773,817
Number of Sequences: 37866
Number of extensions: 925583
Number of successful extensions: 6588
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 773
Number of HSP's successfully gapped in prelim test: 93
Number of HSP's that attempted gapping in prelim test: 4036
Number of HSP's gapped (non-prelim): 1185
length of query: 396
length of database: 18,247,518
effective HSP length: 104
effective length of query: 292
effective length of database: 14,309,454
effective search space: 4178360568
effective search space used: 4178360568
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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