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Search of human proteins with 116734714
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116734714 activin A receptor type II-like 1 [Homo sapiens]
(503 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116734714 activin A receptor type II-like 1 [Homo sapiens] 1040 0.0
gi|116734712 activin A receptor type II-like 1 [Homo sapiens] 1040 0.0
gi|166235898 activin A receptor, type I precursor [Homo sapiens] 581 e-166
gi|4501895 activin A receptor, type I precursor [Homo sapiens] 581 e-166
gi|41349437 bone morphogenetic protein receptor, type IA precurs... 424 e-119
gi|4759226 transforming growth factor, beta receptor I isoform 1... 424 e-119
gi|4757720 activin A receptor, type IB isoform a precursor [Homo... 417 e-117
gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens] 417 e-116
gi|4502431 bone morphogenetic protein receptor, type IB precurso... 416 e-116
gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens] 414 e-116
gi|195963412 transforming growth factor, beta receptor I isoform... 406 e-113
gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens] 385 e-107
gi|33598910 activin A receptor, type IB isoform b precursor [Hom... 377 e-104
gi|33598912 activin A receptor, type IB isoform c precursor [Hom... 330 1e-90
gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens] 269 4e-72
gi|4501897 activin A receptor, type IIA precursor [Homo sapiens] 214 2e-55
gi|67782324 transforming growth factor, beta receptor II isoform... 205 9e-53
gi|67782326 transforming growth factor, beta receptor II isoform... 205 9e-53
gi|116734708 activin A receptor, type IIB precursor [Homo sapiens] 204 2e-52
gi|15451916 bone morphogenetic protein receptor type II precurso... 182 5e-46
gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens] 147 2e-35
gi|40254844 receptor-interacting serine-threonine kinase 3 [Homo... 91 2e-18
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 91 2e-18
gi|187475373 c-src tyrosine kinase [Homo sapiens] 89 7e-18
gi|4758078 c-src tyrosine kinase [Homo sapiens] 89 7e-18
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 86 6e-17
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 84 2e-16
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 84 2e-16
gi|4503787 fyn-related kinase [Homo sapiens] 82 1e-15
gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Hom... 81 3e-15
>gi|116734714 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 1040 bits (2690), Expect = 0.0
Identities = 503/503 (100%), Positives = 503/503 (100%)
Query: 1 MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG 60
MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG
Sbjct: 1 MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG 60
Query: 61 RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA 120
RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA
Sbjct: 61 RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA 120
Query: 121 LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS 180
LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS
Sbjct: 121 LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS 180
Query: 181 DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF 240
DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF
Sbjct: 181 DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF 240
Query: 241 RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL 300
RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL
Sbjct: 241 RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL 300
Query: 301 RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD 360
RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD
Sbjct: 301 RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD 360
Query: 361 YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED 420
YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED
Sbjct: 361 YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED 420
Query: 421 YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL 480
YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL
Sbjct: 421 YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL 480
Query: 481 TALRIKKTLQKISNSPEKPKVIQ 503
TALRIKKTLQKISNSPEKPKVIQ
Sbjct: 481 TALRIKKTLQKISNSPEKPKVIQ 503
>gi|116734712 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 1040 bits (2690), Expect = 0.0
Identities = 503/503 (100%), Positives = 503/503 (100%)
Query: 1 MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG 60
MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG
Sbjct: 1 MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG 60
Query: 61 RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA 120
RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA
Sbjct: 61 RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA 120
Query: 121 LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS 180
LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS
Sbjct: 121 LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS 180
Query: 181 DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF 240
DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF
Sbjct: 181 DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF 240
Query: 241 RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL 300
RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL
Sbjct: 241 RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL 300
Query: 301 RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD 360
RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD
Sbjct: 301 RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD 360
Query: 361 YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED 420
YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED
Sbjct: 361 YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED 420
Query: 421 YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL 480
YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL
Sbjct: 421 YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL 480
Query: 481 TALRIKKTLQKISNSPEKPKVIQ 503
TALRIKKTLQKISNSPEKPKVIQ
Sbjct: 481 TALRIKKTLQKISNSPEKPKVIQ 503
>gi|166235898 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 581 bits (1497), Expect = e-166
Identities = 304/501 (60%), Positives = 362/501 (72%), Gaps = 15/501 (2%)
Query: 11 LMLLMALVTQG-DPVKPSRGP-LVTCTCESPHCKGPT-CRGAWCTVVLVREEGRHPQEHR 67
+++++AL + + KP P L C CE C C G C L +G H + +
Sbjct: 10 VLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQ-K 68
Query: 68 GCGNLHRE---LCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDG---QLAL 121
GC ++ + C+ P+ CC CN N++ L PGT ++ L
Sbjct: 69 GCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKG--KSFPGTQNFHLEVGL 126
Query: 122 ILGPVLALLALVA--LGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLD 179
I+ V+ + L+A LGV RR QE+ E G ++ + GDS L DLLD
Sbjct: 127 IILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLI-TTNVGDSTLADLLD 185
Query: 180 SDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSW 239
CT+GSGSGLPFLVQRTVARQ+ L+ECVGKGRYGEVWRG W GE+VAVKIFSSRDE+SW
Sbjct: 186 HSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSW 245
Query: 240 FRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLA 299
FRETE+YNTV+LRH+NILGFIASDMTSR+SSTQLWLITHYHE GSLYD+LQ TL+
Sbjct: 246 FRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSC 305
Query: 300 LRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGS 359
LR+ +S A GLAHLH+EIFGTQGKPAIAHRD KS+N+LVK N QCCIADLGLAVMHSQ +
Sbjct: 306 LRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQST 365
Query: 360 DYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVE 419
+ LD+GNNPRVGTKRYMAPEVLDE I+ DCF+SYK DIWAFGLVLWE+ARR + NGIVE
Sbjct: 366 NQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVE 425
Query: 420 DYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSAR 479
DY+PPFYDVVPNDPSFEDM+KVVCVDQQ P IPNR +DP L+ LA++M+ECWY NPSAR
Sbjct: 426 DYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSAR 485
Query: 480 LTALRIKKTLQKISNSPEKPK 500
LTALRIKKTL KI NS +K K
Sbjct: 486 LTALRIKKTLTKIDNSLDKLK 506
>gi|4501895 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 581 bits (1497), Expect = e-166
Identities = 304/501 (60%), Positives = 362/501 (72%), Gaps = 15/501 (2%)
Query: 11 LMLLMALVTQG-DPVKPSRGP-LVTCTCESPHCKGPT-CRGAWCTVVLVREEGRHPQEHR 67
+++++AL + + KP P L C CE C C G C L +G H + +
Sbjct: 10 VLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQ-K 68
Query: 68 GCGNLHRE---LCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDG---QLAL 121
GC ++ + C+ P+ CC CN N++ L PGT ++ L
Sbjct: 69 GCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKG--KSFPGTQNFHLEVGL 126
Query: 122 ILGPVLALLALVA--LGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLD 179
I+ V+ + L+A LGV RR QE+ E G ++ + GDS L DLLD
Sbjct: 127 IILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLI-TTNVGDSTLADLLD 185
Query: 180 SDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSW 239
CT+GSGSGLPFLVQRTVARQ+ L+ECVGKGRYGEVWRG W GE+VAVKIFSSRDE+SW
Sbjct: 186 HSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSW 245
Query: 240 FRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLA 299
FRETE+YNTV+LRH+NILGFIASDMTSR+SSTQLWLITHYHE GSLYD+LQ TL+
Sbjct: 246 FRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSC 305
Query: 300 LRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGS 359
LR+ +S A GLAHLH+EIFGTQGKPAIAHRD KS+N+LVK N QCCIADLGLAVMHSQ +
Sbjct: 306 LRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQST 365
Query: 360 DYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVE 419
+ LD+GNNPRVGTKRYMAPEVLDE I+ DCF+SYK DIWAFGLVLWE+ARR + NGIVE
Sbjct: 366 NQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVE 425
Query: 420 DYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSAR 479
DY+PPFYDVVPNDPSFEDM+KVVCVDQQ P IPNR +DP L+ LA++M+ECWY NPSAR
Sbjct: 426 DYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSAR 485
Query: 480 LTALRIKKTLQKISNSPEKPK 500
LTALRIKKTL KI NS +K K
Sbjct: 486 LTALRIKKTLTKIDNSLDKLK 506
>gi|41349437 bone morphogenetic protein receptor, type IA precursor
[Homo sapiens]
Length = 532
Score = 424 bits (1091), Expect = e-119
Identities = 227/482 (47%), Positives = 306/482 (63%), Gaps = 23/482 (4%)
Query: 30 PLVTCTCESPHCKGP----TC-RGAWCTVVLVREEGRHPQEHRGCGNLHRE--LCRGRPT 82
P + C C S HC TC C ++ ++ GC C+ P
Sbjct: 57 PFLKCYC-SGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPK 115
Query: 83 EFVNHY--CCDSHLCNHNVSLVLEATQPPSE-QPGTDGQ---LALILGPVLALLALVALG 136
+ CC ++LCN L+ T PP P DG L L++ + ++A++
Sbjct: 116 AQLRRTIECCRTNLCNQ----YLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFS 171
Query: 137 VLGLW-HVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQ 195
+ H + +R + +L + + E L DL+D ++GSGSGLP LVQ
Sbjct: 172 SCFCYKHYCKSISSRRRYNRDLEQDEAFIPVGES----LKDLIDQSQSSGSGSGLPLLVQ 227
Query: 196 RTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDN 255
RT+A+Q+ +V VGKGRYGEVW G W GE VAVK+F + +E SWFRETEIY TVL+RH+N
Sbjct: 228 RTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHEN 287
Query: 256 ILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHV 315
ILGFIA+D+ S TQL+LIT YHE+GSLYDFL+ TL+ L+LA SAACGL HLH
Sbjct: 288 ILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHT 347
Query: 316 EIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRY 375
EI+GTQGKPAIAHRD KS+N+L+K N CCIADLGLAV + ++ +D+ N RVGTKRY
Sbjct: 348 EIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRY 407
Query: 376 MAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSF 435
MAPEVLDE + + F+ Y DI++FGL++WE+ARR I GIVE+Y+ P+Y++VP+DPS+
Sbjct: 408 MAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSY 467
Query: 436 EDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNS 495
EDM++VVCV + P + NR +D L + ++M ECW NP++RLTALRIKKTL K+ S
Sbjct: 468 EDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVES 527
Query: 496 PE 497
+
Sbjct: 528 QD 529
>gi|4759226 transforming growth factor, beta receptor I isoform 1
precursor [Homo sapiens]
Length = 503
Score = 424 bits (1090), Expect = e-119
Identities = 224/411 (54%), Positives = 274/411 (66%), Gaps = 18/411 (4%)
Query: 88 YCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLALILGPVLALLALVALGVL-----GLWH 142
YCC+ CN + L T S G A+I GPV + + L V + H
Sbjct: 99 YCCNQDHCN---KIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIH 155
Query: 143 VRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQV 202
R E+ L LK DL+ T+GSGSGLP LVQRT+AR +
Sbjct: 156 HRVPNEEDPSLDRPFISEGTTLK----------DLIYDMTTSGSGSGLPLLVQRTIARTI 205
Query: 203 ALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIAS 262
L E +GKGR+GEVWRG W GE VAVKIFSSR+E+SWFRE EIY TV+LRH+NILGFIA+
Sbjct: 206 VLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAA 265
Query: 263 DMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQG 322
D + TQLWL++ YHEHGSL+D+L R T+ ++LA+S A GLAHLH+EI GTQG
Sbjct: 266 DNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQG 325
Query: 323 KPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLD 382
KPAIAHRD KS+N+LVK N CCIADLGLAV H +D +DI N RVGTKRYMAPEVLD
Sbjct: 326 KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLD 385
Query: 383 EQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVV 442
+ I FES+K DI+A GLV WEIARR + GI EDY+ P+YD+VP+DPS E+M+KVV
Sbjct: 386 DSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVV 445
Query: 443 CVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKIS 493
C + P IPNR + L +A++MRECWY N +ARLTALRIKKTL ++S
Sbjct: 446 CEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLS 496
>gi|4757720 activin A receptor, type IB isoform a precursor [Homo
sapiens]
Length = 505
Score = 417 bits (1073), Expect = e-117
Identities = 240/494 (48%), Positives = 302/494 (61%), Gaps = 22/494 (4%)
Query: 14 LMALVTQGDPVKPSRG-PLVTCTCESPHCKGPTCR--GAWCTVVLVREEGRHPQEH--RG 68
L+ L+ G RG + C C S TC GA C V + +G EH R
Sbjct: 13 LVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGA-CMVSIFNLDG---MEHHVRT 68
Query: 69 CGNLHRELCRGRP------TEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLAL- 121
C + G+P + N +CC + CN V E P G + L
Sbjct: 69 CIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELV 128
Query: 122 --ILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLD 179
I GPV L ++ + L + + +R ++ L E + L D L DL+
Sbjct: 129 GIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSK----DKTLQDLVY 184
Query: 180 SDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSW 239
T+GSGSGLP VQRTVAR + L E +GKGR+GEVWRG W G VAVKIFSSR+E+SW
Sbjct: 185 DLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSW 244
Query: 240 FRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLA 299
FRE EIY TV+LRH+NILGFIA+D + TQLWL++ YHEHGSL+D+L R T+
Sbjct: 245 FREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGM 304
Query: 300 LRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGS 359
++LA+SAA GLAHLH+EI GTQGKP IAHRD KS+N+LVK N C IADLGLAV H +
Sbjct: 305 IKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVT 364
Query: 360 DYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVE 419
D +DI N RVGTKRYMAPEVLDE I F+S+K DI+A GLV WEIARR G+ E
Sbjct: 365 DTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHE 424
Query: 420 DYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSAR 479
+Y+ P+YD+VP+DPS E+M+KVVC + P IPN + L + +MMRECWY N +AR
Sbjct: 425 EYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAAR 484
Query: 480 LTALRIKKTLQKIS 493
LTALRIKKTL ++S
Sbjct: 485 LTALRIKKTLSQLS 498
>gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens]
Length = 493
Score = 417 bits (1071), Expect = e-116
Identities = 224/466 (48%), Positives = 301/466 (64%), Gaps = 14/466 (3%)
Query: 32 VTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPTEFVNHYCCD 91
V C+S + T W +V+L + + + L+ ++ CC
Sbjct: 29 VCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCF 88
Query: 92 SHLCNHNVSLVLEATQPPSEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQ---- 147
+ CN N++L L P + + G +LA+I+ + LL++ A+ L +W + RQ
Sbjct: 89 TDFCN-NITLHLPTASPNAPKLGPM-ELAIIITVPVCLLSIAAM--LTVWACQGRQCSYR 144
Query: 148 -EKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVE 206
+K+ + L E +L+ L DL+ +GSGSGLP LVQRT+AR + L E
Sbjct: 145 KKKRPNVEEPLSECNLV-----NAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQE 199
Query: 207 CVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTS 266
VGKGR+GEVW G W GE VAVKIFSSRDE+SWFRE EIY TV+LRH+NILGFIA+D
Sbjct: 200 IVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKD 259
Query: 267 RNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAI 326
+ TQLWL++ YHE GSLYD+L R + ++LA+S A GLAHLH+EI GTQGKPAI
Sbjct: 260 NGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAI 319
Query: 327 AHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIR 386
AHRD KS+N+LVK C IADLGLAV H + +DI NP+VGTKRYMAPE+LD+ +
Sbjct: 320 AHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMN 379
Query: 387 TDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQ 446
+ FES+K DI++ GLV WEIARR V GIVE+Y+ P+YD+VP+DPS E+M+KVVC +
Sbjct: 380 VNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQK 439
Query: 447 QTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKI 492
P+IPN+ + L + ++MRECWY N +ARLTALRIKKT+ ++
Sbjct: 440 FRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 485
>gi|4502431 bone morphogenetic protein receptor, type IB precursor
[Homo sapiens]
Length = 502
Score = 416 bits (1068), Expect = e-116
Identities = 225/492 (45%), Positives = 309/492 (62%), Gaps = 25/492 (5%)
Query: 21 GDPVKPSRGPLVT-CTCESPHCKGPTCRG-----AWCTVVLVREEGRHPQEHRGCGNLHR 74
G+ P+ P V C C HC + +C ++ ++ P GC L
Sbjct: 18 GESTAPTPRPKVLRCKCHH-HCPEDSVNNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEG 76
Query: 75 E--LCRGRPTEFVNHY---CCDSHLCNHNVSLVLEATQPP-SEQPGTDGQL---ALILGP 125
CR P C + + CN + L T PP + DG + AL++
Sbjct: 77 SDFQCRDTPIPHQRRSIECCTERNECNKD----LHPTLPPLKNRDFVDGPIHHRALLISV 132
Query: 126 VLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTG 185
+ L LV + +L + +RQE + L + + E L DL++ ++G
Sbjct: 133 TVCSLLLVLI-ILFCYFRYKRQETRPRYSIGLEQDETYIPPGES----LRDLIEQSQSSG 187
Query: 186 SGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEI 245
SGSGLP LVQRT+A+Q+ +V+ +GKGRYGEVW G W GE VAVK+F + +E SWFRETEI
Sbjct: 188 SGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEI 247
Query: 246 YNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVS 305
Y TVL+RH+NILGFIA+D+ S TQL+LIT YHE+GSLYD+L+ TL+ L+LA S
Sbjct: 248 YQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYS 307
Query: 306 AACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIG 365
+ GL HLH EIF TQGKPAIAHRD KS+N+LVK N CCIADLGLAV ++ +DI
Sbjct: 308 SVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIP 367
Query: 366 NNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPF 425
N RVGTKRYM PEVLDE + + F+SY D+++FGL+LWE+ARR + GIVE+Y+ P+
Sbjct: 368 PNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPY 427
Query: 426 YDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRI 485
+D+VP+DPS+EDM+++VC+ + P+ PNR ++D L + ++M ECW NP++RLTALR+
Sbjct: 428 HDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRV 487
Query: 486 KKTLQKISNSPE 497
KKTL K+S S +
Sbjct: 488 KKTLAKMSESQD 499
>gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens]
Length = 443
Score = 414 bits (1065), Expect = e-116
Identities = 216/409 (52%), Positives = 283/409 (69%), Gaps = 14/409 (3%)
Query: 89 CCDSHLCNHNVSLVLEATQPPSEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQ- 147
CC + CN N++L L P + + G +LA+I+ + LL++ A+ L +W + RQ
Sbjct: 36 CCFTDFCN-NITLHLPTASPNAPKLGPM-ELAIIITVPVCLLSIAAM--LTVWACQGRQC 91
Query: 148 ----EKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVA 203
+K+ + L E +L+ L DL+ +GSGSGLP LVQRT+AR +
Sbjct: 92 SYRKKKRPNVEEPLSECNLV-----NAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIV 146
Query: 204 LVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASD 263
L E VGKGR+GEVW G W GE VAVKIFSSRDE+SWFRE EIY TV+LRH+NILGFIA+D
Sbjct: 147 LQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAAD 206
Query: 264 MTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGK 323
+ TQLWL++ YHE GSLYD+L R + ++LA+S A GLAHLH+EI GTQGK
Sbjct: 207 NKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGK 266
Query: 324 PAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDE 383
PAIAHRD KS+N+LVK C IADLGLAV H + +DI NP+VGTKRYMAPE+LD+
Sbjct: 267 PAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDD 326
Query: 384 QIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVC 443
+ + FES+K DI++ GLV WEIARR V GIVE+Y+ P+YD+VP+DPS E+M+KVVC
Sbjct: 327 TMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVC 386
Query: 444 VDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKI 492
+ P+IPN+ + L + ++MRECWY N +ARLTALRIKKT+ ++
Sbjct: 387 DQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 435
>gi|195963412 transforming growth factor, beta receptor I isoform 2
precursor [Homo sapiens]
Length = 426
Score = 406 bits (1043), Expect = e-113
Identities = 195/306 (63%), Positives = 237/306 (77%)
Query: 188 SGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYN 247
+GLP LVQRT+AR + L E +GKGR+GEVWRG W GE VAVKIFSSR+E+SWFRE EIY
Sbjct: 114 TGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQ 173
Query: 248 TVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAA 307
TV+LRH+NILGFIA+D + TQLWL++ YHEHGSL+D+L R T+ ++LA+S A
Sbjct: 174 TVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTA 233
Query: 308 CGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNN 367
GLAHLH+EI GTQGKPAIAHRD KS+N+LVK N CCIADLGLAV H +D +DI N
Sbjct: 234 SGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPN 293
Query: 368 PRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYD 427
RVGTKRYMAPEVLD+ I FES+K DI+A GLV WEIARR + GI EDY+ P+YD
Sbjct: 294 HRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYD 353
Query: 428 VVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKK 487
+VP+DPS E+M+KVVC + P IPNR + L +A++MRECWY N +ARLTALRIKK
Sbjct: 354 LVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK 413
Query: 488 TLQKIS 493
TL ++S
Sbjct: 414 TLSQLS 419
>gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens]
Length = 413
Score = 385 bits (989), Expect = e-107
Identities = 186/305 (60%), Positives = 233/305 (76%)
Query: 188 SGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYN 247
+GLP LVQRT+AR + L E VGKGR+GEVW G W GE VAVKIFSSRDE+SWFRE EIY
Sbjct: 101 TGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 160
Query: 248 TVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAA 307
TV+LRH+NILGFIA+D + TQLWL++ YHE GSLYD+L R + ++LA+S A
Sbjct: 161 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 220
Query: 308 CGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNN 367
GLAHLH+EI GTQGKPAIAHRD KS+N+LVK C IADLGLAV H + +DI N
Sbjct: 221 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 280
Query: 368 PRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYD 427
P+VGTKRYMAPE+LD+ + + FES+K DI++ GLV WEIARR V GIVE+Y+ P+YD
Sbjct: 281 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 340
Query: 428 VVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKK 487
+VP+DPS E+M+KVVC + P+IPN+ + L + ++MRECWY N +ARLTALRIKK
Sbjct: 341 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 400
Query: 488 TLQKI 492
T+ ++
Sbjct: 401 TISQL 405
>gi|33598910 activin A receptor, type IB isoform b precursor [Homo
sapiens]
Length = 476
Score = 377 bits (967), Expect = e-104
Identities = 218/454 (48%), Positives = 274/454 (60%), Gaps = 22/454 (4%)
Query: 14 LMALVTQGDPVKPSRG-PLVTCTCESPHCKGPTCR--GAWCTVVLVREEGRHPQEH--RG 68
L+ L+ G RG + C C S TC GA C V + +G EH R
Sbjct: 13 LVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGA-CMVSIFNLDG---MEHHVRT 68
Query: 69 CGNLHRELCRGRP------TEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLAL- 121
C + G+P + N +CC + CN V E P G + L
Sbjct: 69 CIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELV 128
Query: 122 --ILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLD 179
I GPV L ++ + L + + +R ++ L E + L D L DL+
Sbjct: 129 GIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSK----DKTLQDLVY 184
Query: 180 SDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSW 239
T+GSGSGLP VQRTVAR + L E +GKGR+GEVWRG W G VAVKIFSSR+E+SW
Sbjct: 185 DLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSW 244
Query: 240 FRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLA 299
FRE EIY TV+LRH+NILGFIA+D + TQLWL++ YHEHGSL+D+L R T+
Sbjct: 245 FREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGM 304
Query: 300 LRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGS 359
++LA+SAA GLAHLH+EI GTQGKP IAHRD KS+N+LVK N C IADLGLAV H +
Sbjct: 305 IKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVT 364
Query: 360 DYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVE 419
D +DI N RVGTKRYMAPEVLDE I F+S+K DI+A GLV WEIARR G+ E
Sbjct: 365 DTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHE 424
Query: 420 DYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPN 453
+Y+ P+YD+VP+DPS E+M+KVVC + P IPN
Sbjct: 425 EYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPN 458
>gi|33598912 activin A receptor, type IB isoform c precursor [Homo
sapiens]
Length = 487
Score = 330 bits (847), Expect = 1e-90
Identities = 197/412 (47%), Positives = 244/412 (59%), Gaps = 22/412 (5%)
Query: 14 LMALVTQGDPVKPSRG-PLVTCTCESPHCKGPTCR--GAWCTVVLVREEGRHPQEH--RG 68
L+ L+ G RG + C C S TC GA C V + +G EH R
Sbjct: 13 LVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGA-CMVSIFNLDG---MEHHVRT 68
Query: 69 CGNLHRELCRGRP------TEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLAL- 121
C + G+P + N +CC + CN V E P G + L
Sbjct: 69 CIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELV 128
Query: 122 --ILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLD 179
I GPV L ++ + L + + +R ++ L E + L D L DL+
Sbjct: 129 GIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSK----DKTLQDLVY 184
Query: 180 SDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSW 239
T+GSGSGLP VQRTVAR + L E +GKGR+GEVWRG W G VAVKIFSSR+E+SW
Sbjct: 185 DLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSW 244
Query: 240 FRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLA 299
FRE EIY TV+LRH+NILGFIA+D + TQLWL++ YHEHGSL+D+L R T+
Sbjct: 245 FREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGM 304
Query: 300 LRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGS 359
++LA+SAA GLAHLH+EI GTQGKP IAHRD KS+N+LVK N C IADLGLAV H +
Sbjct: 305 IKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVT 364
Query: 360 DYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARR 411
D +DI N RVGTKRYMAPEVLDE I F+S+K DI+A GLV WEIARR
Sbjct: 365 DTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARR 416
>gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens]
Length = 336
Score = 269 bits (688), Expect = 4e-72
Identities = 130/228 (57%), Positives = 169/228 (74%)
Query: 265 TSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKP 324
T + TQLWL++ YHE GSLYD+L R + ++LA+S A GLAHLH+EI GTQGKP
Sbjct: 101 TDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKP 160
Query: 325 AIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQ 384
AIAHRD KS+N+LVK C IADLGLAV H + +DI NP+VGTKRYMAPE+LD+
Sbjct: 161 AIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDT 220
Query: 385 IRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCV 444
+ + FES+K DI++ GLV WEIARR V GIVE+Y+ P+YD+VP+DPS E+M+KVVC
Sbjct: 221 MNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCD 280
Query: 445 DQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKI 492
+ P+IPN+ + L + ++MRECWY N +ARLTALRIKKT+ ++
Sbjct: 281 QKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 328
>gi|4501897 activin A receptor, type IIA precursor [Homo sapiens]
Length = 513
Score = 214 bits (544), Expect = 2e-55
Identities = 139/401 (34%), Positives = 214/401 (53%), Gaps = 39/401 (9%)
Query: 89 CCDSHLCNHNVSLV--LEATQPPSEQPGTDGQ--LALILGPVLALLALVALGVLGLWHVR 144
CC+ ++CN S +E TQP S P T ++L ++ L+ + + + W R
Sbjct: 104 CCEGNMCNEKFSYFPEMEVTQPTSN-PVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYR 162
Query: 145 RRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVAL 204
H ++ +++ + G LL GL + + L
Sbjct: 163 ---------HHKMAYPPVLVPTQDPGPPPPSPLL----------GL---------KPLQL 194
Query: 205 VECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDM 264
+E +GR+G VW+ E VAVKIF +D+QSW E E+Y+ ++H+NIL FI ++
Sbjct: 195 LEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEK 254
Query: 265 TSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQG-- 322
+ LWLIT +HE GSL DFL+ + + +A + A GLA+LH +I G +
Sbjct: 255 RGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGH 314
Query: 323 KPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLD 382
KPAI+HRD KS+NVL+K+NL CIAD GLA+ G D + +VGT+RYMAPEVL+
Sbjct: 315 KPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPEVLE 372
Query: 383 EQIRTDCFESYKWTDIWAFGLVLWEIARR-TIVNGIVEDYRPPFYDVVPNDPSFEDMKKV 441
I +++ D++A GLVLWE+A R T +G V++Y PF + + PS EDM++V
Sbjct: 373 GAINFQ-RDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEV 431
Query: 442 VCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTA 482
V ++ P + + ++ L + + ECW + ARL+A
Sbjct: 432 VVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSA 472
>gi|67782324 transforming growth factor, beta receptor II isoform B
precursor [Homo sapiens]
Length = 567
Score = 205 bits (521), Expect = 9e-53
Identities = 138/429 (32%), Positives = 217/429 (50%), Gaps = 27/429 (6%)
Query: 80 RPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDG-QLALILGPVLALLAL----VA 134
+P E C S CN N+ SE+ T L L++ V + L VA
Sbjct: 128 KPGETFFMCSCSSDECNDNIIF--------SEEYNTSNPDLLLVIFQVTGISLLPPLGVA 179
Query: 135 LGVLGLWHVRRRQEKQRGLHS-ELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFL 193
+ V+ +++ R +Q+ + E G++ +++ SE +L+ D + S + +
Sbjct: 180 ISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEH----CAIILEDDRSDISSTCANNI 235
Query: 194 VQRTVARQVALVECVGKGRYGEVWRGLWHG------ESVAVKIFSSRDEQSWFRETEIYN 247
T + L VGKGR+ EV++ E+VAVKIF + SW E +I++
Sbjct: 236 NHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFS 295
Query: 248 TVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAA 307
+ L+H+NIL F+ ++ Q WLIT +H G+L ++L R + +L S A
Sbjct: 296 DINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLA 355
Query: 308 CGLAHLHVEIFGTQGKPA--IAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIG 365
G+AHLH + G+P I HRD KS N+LVK++L CC+ D GL++ D+
Sbjct: 356 RGIAHLHSD-HTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLA 414
Query: 366 NNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPF 425
N+ +VGT RYMAPEVL+ ++ + ES+K TD+++ LVLWE+ R G V+DY PPF
Sbjct: 415 NSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPF 474
Query: 426 YDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRI 485
V P E MK V D+ P IP+ + + + + ECW +P ARLTA +
Sbjct: 475 GSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCV 534
Query: 486 KKTLQKISN 494
+ ++ +
Sbjct: 535 AERFSELEH 543
>gi|67782326 transforming growth factor, beta receptor II isoform A
precursor [Homo sapiens]
Length = 592
Score = 205 bits (521), Expect = 9e-53
Identities = 138/429 (32%), Positives = 217/429 (50%), Gaps = 27/429 (6%)
Query: 80 RPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDG-QLALILGPVLALLAL----VA 134
+P E C S CN N+ SE+ T L L++ V + L VA
Sbjct: 153 KPGETFFMCSCSSDECNDNIIF--------SEEYNTSNPDLLLVIFQVTGISLLPPLGVA 204
Query: 135 LGVLGLWHVRRRQEKQRGLHS-ELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFL 193
+ V+ +++ R +Q+ + E G++ +++ SE +L+ D + S + +
Sbjct: 205 ISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEH----CAIILEDDRSDISSTCANNI 260
Query: 194 VQRTVARQVALVECVGKGRYGEVWRGLWHG------ESVAVKIFSSRDEQSWFRETEIYN 247
T + L VGKGR+ EV++ E+VAVKIF + SW E +I++
Sbjct: 261 NHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFS 320
Query: 248 TVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAA 307
+ L+H+NIL F+ ++ Q WLIT +H G+L ++L R + +L S A
Sbjct: 321 DINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLA 380
Query: 308 CGLAHLHVEIFGTQGKPA--IAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIG 365
G+AHLH + G+P I HRD KS N+LVK++L CC+ D GL++ D+
Sbjct: 381 RGIAHLHSD-HTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLA 439
Query: 366 NNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPF 425
N+ +VGT RYMAPEVL+ ++ + ES+K TD+++ LVLWE+ R G V+DY PPF
Sbjct: 440 NSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPF 499
Query: 426 YDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRI 485
V P E MK V D+ P IP+ + + + + ECW +P ARLTA +
Sbjct: 500 GSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCV 559
Query: 486 KKTLQKISN 494
+ ++ +
Sbjct: 560 AERFSELEH 568
>gi|116734708 activin A receptor, type IIB precursor [Homo sapiens]
Length = 512
Score = 204 bits (519), Expect = 2e-52
Identities = 137/414 (33%), Positives = 216/414 (52%), Gaps = 39/414 (9%)
Query: 89 CCDSHLCNHNVSLVLEATQPPS--EQPGTDGQLALILG-PVLALLALVALGVLGLWHVRR 145
CC+ + CN + + EA P E P T L +L +L + L + +L W R
Sbjct: 103 CCEGNFCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRH 162
Query: 146 RQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALV 205
R+ H ++ E G P + + L+
Sbjct: 163 RKPPYG--HVDIHEDP---------------------------GPPPPSPLVGLKPLQLL 193
Query: 206 ECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMT 265
E +GR+G VW+ + VAVKIF +D+QSW E EI++T ++H+N+L FIA++
Sbjct: 194 EIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKR 253
Query: 266 SRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQG--- 322
N +LWLIT +H+ GSL D+L+ + + +A + + GL++LH ++ +G
Sbjct: 254 GSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGH 313
Query: 323 KPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLD 382
KP+IAHRDFKS+NVL+KS+L +AD GLAV G D + +VGT+RYMAPEVL+
Sbjct: 314 KPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAPEVLE 371
Query: 383 EQIRTDCFESYKWTDIWAFGLVLWE-IARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKV 441
I +++ D++A GLVLWE ++R +G V++Y PF + + PS E++++V
Sbjct: 372 GAINFQ-RDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEV 430
Query: 442 VCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNS 495
V + PTI + P L+ L + ECW + ARL+A +++ + I S
Sbjct: 431 VVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRS 484
>gi|15451916 bone morphogenetic protein receptor type II precursor
[Homo sapiens]
Length = 1038
Score = 182 bits (463), Expect = 5e-46
Identities = 153/493 (31%), Positives = 225/493 (45%), Gaps = 72/493 (14%)
Query: 42 KGPTCRGAWCTVVLVREEGRHPQEHRGCGN-------LHRELC--RGRPTEFVN----HY 88
KG TC G W + +G +GC + H E C P N
Sbjct: 62 KGSTCYGLW-----EKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFC 116
Query: 89 CCDSHLCNHNVSLVLEATQPPSEQP-------GTDGQLALILGPVLALLALVALGVLGLW 141
CC + LCN N + E PP P D + + L V L L+ G
Sbjct: 117 CCSTDLCNVNFT---ENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFG-- 171
Query: 142 HVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQ 201
+ ++++GLHS + + ASE LD D
Sbjct: 172 YRMLTGDRKQGLHSM---NMMEAAASEPS-------LDLD-------------------N 202
Query: 202 VALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIA 261
+ L+E +G+GRYG V++G VAVK+FS + Q++ E IY L+ HDNI FI
Sbjct: 203 LKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIV 262
Query: 262 SD-MTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEI-FG 319
D + + + L+ Y+ +GSL +L T + + RLA S GLA+LH E+ G
Sbjct: 263 GDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRG 322
Query: 320 TQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNN-----PRVGTKR 374
KPAI+HRD SRNVLVK++ C I+D GL+ M G+ + G VGT R
Sbjct: 323 DHYKPAISHRDLNSRNVLVKNDGTCVISDFGLS-MRLTGNRLVRPGEEDNAAISEVGTIR 381
Query: 375 YMAPEVLDEQIR-TDCFESYKWTDIWAFGLVLWEIARR---TIVNGIVEDYRPPFYDVVP 430
YMAPEVL+ + DC + K D++A GL+ WEI R V +Y+ F V
Sbjct: 382 YMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVG 441
Query: 431 NDPSFEDMKKVVCVDQQTPTIPNRLAADPV-LSGLAQMMRECWYPNPSARLTALRIKKTL 489
N P+FEDM+ +V ++Q P P + + + L + + +CW + ARLTA ++ +
Sbjct: 442 NHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERM 501
Query: 490 QKISNSPEKPKVI 502
++ E+ K +
Sbjct: 502 AELMMIWERNKSV 514
>gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens]
Length = 573
Score = 147 bits (371), Expect = 2e-35
Identities = 140/497 (28%), Positives = 222/497 (44%), Gaps = 89/497 (17%)
Query: 46 CRGAWCTV---VLVREEGRHPQEHRGCGNLHRELC-RGRPTEFVNHYCCD--SHLCNHNV 99
C G W V +G + GC +LH + R P+ + C + CN N
Sbjct: 61 CFGIWNLTQDRAQVEMQGCRDSDEPGCESLHCDPSPRAHPSPGSTLFTCSCGTDFCNANY 120
Query: 100 SLVLEATQPPSEQPGTDGQ------------LALILGPVLALLALVALGVLGLWHVRRRQ 147
S + PP PGT G +AL+L L LL L+ LG + L ++R+
Sbjct: 121 SHL-----PPPGSPGTPGSQGPQAAPGESIWMALVLLG-LFLLLLLLLGSIILALLQRKN 174
Query: 148 EKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVEC 207
+ RG + SG + V+ ++ +
Sbjct: 175 YRVRG--------------------------EPVPEPRPDSGRDWSVELQELPELCFSQV 208
Query: 208 VGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSR 267
+ +G + VW G G+ VA+K F R + E +Y L+HD+I+ FI + SR
Sbjct: 209 IREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRFITA---SR 265
Query: 268 NSSTQLW----LITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGT-QG 322
+L L+ H GSL +L + T + +LR+A+S A GLA LH E + Q
Sbjct: 266 GGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQY 325
Query: 323 KPAIAHRDFKSRNVLVKSNLQCCIADLGLAVM-------------HSQGSDYLDIGNNPR 369
KP IAHRD S+NVL++ + C I DLGLA++ QG +
Sbjct: 326 KPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAI-----ME 380
Query: 370 VGTKRYMAPEVLDEQI-RTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDV 428
GT+RYMAPE+LD+ + D + + DI++ L+LWEI R + D PP + +
Sbjct: 381 AGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSR--CPDLRPDSSPPPFQL 438
Query: 429 -----VPNDPSFEDMKKVVCVDQQTPTIPNR---LAADPVLSGLAQMMRECWYPNPSARL 480
+ N P+ +++ + +++ P IP+ A DP GL +++ +CW +P ARL
Sbjct: 439 AYEAELGNTPTSDELWALAVQERRRPYIPSTWRCFATDP--DGLRELLEDCWDADPEARL 496
Query: 481 TALRIKKTLQKISNSPE 497
TA +++ L +++ E
Sbjct: 497 TAECVQQRLAALAHPQE 513
>gi|40254844 receptor-interacting serine-threonine kinase 3 [Homo
sapiens]
Length = 518
Score = 91.3 bits (225), Expect = 2e-18
Identities = 80/281 (28%), Positives = 125/281 (44%), Gaps = 39/281 (13%)
Query: 206 ECVGKGRYGEVWRGLWH--GESVAVKIFSSRDEQSWFRE-TEIYNTVLLRHDNILGFIAS 262
E VGKG +G V+R G VAVKI +S+ + + N +LR + ++ +
Sbjct: 25 ELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNW 84
Query: 263 DMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPH-LALRLAVSAACGLAHLHVEIFGTQ 321
D + + L+T + E+GSL LQ Q P L RL G+ +LH +
Sbjct: 85 DQDPKPA-----LVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQ----- 134
Query: 322 GKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVL 381
P + HRD K NVL+ L +AD GL+ QG G+ GT Y+APE+
Sbjct: 135 -NPVLLHRDLKPSNVLLDPELHVKLADFGLSTF--QGGSQSGTGSGEPGGTLGYLAPELF 191
Query: 382 DEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKV 441
R ++ +D+++FG+++W + V +P +PS + +
Sbjct: 192 VNVNR----KASTASDVYSFGILMWAVLAGREVE-------------LPTEPSL--VYEA 232
Query: 442 VCVDQQTPT---IPNRLAADPVLSGLAQMMRECWYPNPSAR 479
VC Q P+ +P P L GL ++M+ CW P R
Sbjct: 233 VCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDR 273
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 90.9 bits (224), Expect = 2e-18
Identities = 86/318 (27%), Positives = 138/318 (43%), Gaps = 58/318 (18%)
Query: 193 LVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDE-------QSWFRETEI 245
L Q ++ L E +G G +G+V+R LW GE VAVK E + +E +
Sbjct: 89 LPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARL 148
Query: 246 YNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVS 305
+ L+H NI+ + + + L L+ Y G+L L + + PH+ + AV
Sbjct: 149 FGA--LQHPNIIALRGACL----NPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQ 202
Query: 306 AACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQ--------CCIADLGLAVMHSQ 357
A G+ +LH I HRD KS N+L+ ++ I D GLA
Sbjct: 203 VARGMNYLH-----NDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLA----- 252
Query: 358 GSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGI 417
++ GT +MAPEV IR F K +D+W+FG++LWE+ +
Sbjct: 253 -REWHKTTKMSAAGTYAWMAPEV----IRLSLFS--KSSDVWSFGVLLWELLTGEV---- 301
Query: 418 VEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPS 477
P+ ++ ++ V +++ T IP+ +P A+++ ECW P+P
Sbjct: 302 ------PYREIDALAVAYG-----VAMNKLTLPIPS-TCPEP----FARLLEECWDPDPH 345
Query: 478 ARLTALRIKKTLQKISNS 495
R I K L+ I S
Sbjct: 346 GRPDFGSILKRLEVIEQS 363
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 89.4 bits (220), Expect = 7e-18
Identities = 79/297 (26%), Positives = 137/297 (46%), Gaps = 50/297 (16%)
Query: 200 RQVALVECVGKGRYGEVWRGLWHGESVAVK-IFSSRDEQSWFRETEIYNTVLLRHDNILG 258
+++ L++ +GKG +G+V G + G VAVK I + Q++ E + LRH N++
Sbjct: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQ--LRHSNLVQ 250
Query: 259 FIASDMTSRNSSTQLWLITHYHEHGSLYDFLQ---RQTLEPHLALRLAVSAACGLAHLHV 315
+ + + L+++T Y GSL D+L+ R L L+ ++ + +L
Sbjct: 251 LLGVIVEEKGG---LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307
Query: 316 EIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRY 375
F HRD +RNVLV + ++D GL + S D G P ++
Sbjct: 308 NNF--------VHRDLAARNVLVSEDNVAKVSDFGLT---KEASSTQDTGKLP----VKW 352
Query: 376 MAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSF 435
APE L E+ + +D+W+FG++LWEI G V R P DVVP
Sbjct: 353 TAPEALREK------KFSTKSDVWSFGILLWEI----YSFGRVPYPRIPLKDVVPR---- 398
Query: 436 EDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKI 492
++K +D A D + ++M+ CW+ + + R + L++++ L+ I
Sbjct: 399 --VEKGYKMD----------APDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHI 443
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 89.4 bits (220), Expect = 7e-18
Identities = 79/297 (26%), Positives = 137/297 (46%), Gaps = 50/297 (16%)
Query: 200 RQVALVECVGKGRYGEVWRGLWHGESVAVK-IFSSRDEQSWFRETEIYNTVLLRHDNILG 258
+++ L++ +GKG +G+V G + G VAVK I + Q++ E + LRH N++
Sbjct: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQ--LRHSNLVQ 250
Query: 259 FIASDMTSRNSSTQLWLITHYHEHGSLYDFLQ---RQTLEPHLALRLAVSAACGLAHLHV 315
+ + + L+++T Y GSL D+L+ R L L+ ++ + +L
Sbjct: 251 LLGVIVEEKGG---LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307
Query: 316 EIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRY 375
F HRD +RNVLV + ++D GL + S D G P ++
Sbjct: 308 NNF--------VHRDLAARNVLVSEDNVAKVSDFGLT---KEASSTQDTGKLP----VKW 352
Query: 376 MAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSF 435
APE L E+ + +D+W+FG++LWEI G V R P DVVP
Sbjct: 353 TAPEALREK------KFSTKSDVWSFGILLWEI----YSFGRVPYPRIPLKDVVPR---- 398
Query: 436 EDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKI 492
++K +D A D + ++M+ CW+ + + R + L++++ L+ I
Sbjct: 399 --VEKGYKMD----------APDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHI 443
>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
sapiens]
Length = 847
Score = 86.3 bits (212), Expect = 6e-17
Identities = 87/309 (28%), Positives = 134/309 (43%), Gaps = 60/309 (19%)
Query: 200 RQVALVECVGKGRYGEVWRGLWHGESVAVKIFS-------SRDEQSWFRETEIYNTVLLR 252
+++ L E +G G +G+V+RG W GE VAVK S +S +E ++ +L
Sbjct: 115 QELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLF--AMLA 172
Query: 253 HDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAH 312
H NI+ A + N L L+ Y G L L + + PH+ + AV A G+ +
Sbjct: 173 HPNIIALKAVCLEEPN----LCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHY 228
Query: 313 LHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQ--------CCIADLGLAVMHSQGSDYLDI 364
LH E + HRD KS N+L+ ++ I D GLA ++
Sbjct: 229 LHCEAL-----VPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLA------REWHKT 277
Query: 365 GNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTI-VNGIVEDYRP 423
GT +MAPEV I+ F K +D+W+FG++LWE+ + GI D
Sbjct: 278 TQMSAAGTYAWMAPEV----IKASTFS--KGSDVWSFGVLLWELLTGEVPYRGI--DCLA 329
Query: 424 PFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTAL 483
Y V V++ T IP+ +P AQ+M +CW +P R
Sbjct: 330 VAYG--------------VAVNKLTLPIPS-TCPEP----FAQLMADCWAQDPHRRPDFA 370
Query: 484 RIKKTLQKI 492
I + L+ +
Sbjct: 371 SILQQLEAL 379
Score = 30.0 bits (66), Expect = 5.1
Identities = 14/28 (50%), Positives = 18/28 (64%)
Query: 185 GSGSGLPFLVQRTVARQVALVECVGKGR 212
GS SG P L+QR + R AL+ +G GR
Sbjct: 632 GSSSGTPKLIQRALLRGTALLASLGLGR 659
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 84.3 bits (207), Expect = 2e-16
Identities = 85/329 (25%), Positives = 138/329 (41%), Gaps = 81/329 (24%)
Query: 201 QVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQ-------SWFRETEIYNTVLLRH 253
++ L E +G G +G+V+R W G+ VAVK EQ S RE ++ +LRH
Sbjct: 123 RLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLF--AMLRH 180
Query: 254 DNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFL---------------QRQTLEPHL 298
NI+ + L L+ + G+L L + + + PH+
Sbjct: 181 PNIIELRGVCL----QQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHV 236
Query: 299 ALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQ---CC-----IADLG 350
+ AV A G+ +LH E F I HRD KS N+L+ ++ C I D G
Sbjct: 237 LVNWAVQIARGMLYLHEEAF-----VPILHRDLKSSNILLLEKIEHDDICNKTLKITDFG 291
Query: 351 LAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIAR 410
LA ++ GT +MAPEV+ + + K +DIW++G++LWE+
Sbjct: 292 LA------REWHRTTKMSTAGTYAWMAPEVIKSSLFS------KGSDIWSYGVLLWELLT 339
Query: 411 RTI----VNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQ 466
+ ++G+ Y V V++ T IP+ +P A+
Sbjct: 340 GEVPYRGIDGLAVAYG-------------------VAVNKLTLPIPS-TCPEP----FAK 375
Query: 467 MMRECWYPNPSARLTALRIKKTLQKISNS 495
+M+ECW +P R + I + L I +
Sbjct: 376 LMKECWQQDPHIRPSFALILEQLTAIEGA 404
>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
sapiens]
Length = 1118
Score = 84.3 bits (207), Expect = 2e-16
Identities = 85/321 (26%), Positives = 138/321 (42%), Gaps = 68/321 (21%)
Query: 201 QVALVECVGKGRYGEVWRGLWHGESVAVKIFS-------SRDEQSWFRETEIYNTVLLRH 253
++ L E +G G +G+V+R W G+ VAVK S+ ++ +E +++ +L+H
Sbjct: 143 ELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLF--AMLKH 200
Query: 254 DNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHL 313
NI+ + N L L+ + G L L + + P + + AV A G+ +L
Sbjct: 201 PNIIALRGVCLKEPN----LCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYL 256
Query: 314 HVEIFGTQGKPAIAHRDFKSRNVLV--------KSNLQCCIADLGLAVMHSQGSDYLDIG 365
H E I HRD KS N+L+ SN I D GLA ++
Sbjct: 257 HDEAI-----VPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLA------REWHRTT 305
Query: 366 NNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTI----VNGIVEDY 421
GT +MAPEV IR F K +D+W++G++LWE+ + ++G+ Y
Sbjct: 306 KMSAAGTYAWMAPEV----IRASMFS--KGSDVWSYGVLLWELLTGEVPFRGIDGLAVAY 359
Query: 422 RPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLT 481
V +++ IP+ +P A++M +CW P+P +R +
Sbjct: 360 G-------------------VAMNKLALPIPS-TCPEP----FAKLMEDCWNPDPHSRPS 395
Query: 482 ALRIKKTLQKISNSP--EKPK 500
I L I S E PK
Sbjct: 396 FTNILDQLTTIEESGFFEMPK 416
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 81.6 bits (200), Expect = 1e-15
Identities = 70/214 (32%), Positives = 109/214 (50%), Gaps = 28/214 (13%)
Query: 202 VALVECVGKGRYGEVWRGLWHGES-VAVKIF--SSRDEQSWFRETEIYNTVLLRHDNILG 258
+ L++ +G G++GEVW GLW+ + VAVK S D + RE +I LRH ++
Sbjct: 234 IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKN--LRHPKLIQ 291
Query: 259 FIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQT-LEPHLA--LRLAVSAACGLAHLHV 315
A +++IT HGSL ++LQ T + HL + +A A G+A+L
Sbjct: 292 LYA----VCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLES 347
Query: 316 EIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLA-VMHSQGSDYLDIGNNPRVGTKR 374
+ HRD +RNVLV + +AD GLA V D + + ++ K
Sbjct: 348 RNY--------IHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVK- 398
Query: 375 YMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEI 408
+ APE IR++ F S K +D+W+FG++L+EI
Sbjct: 399 WTAPEA----IRSNKF-SIK-SDVWSFGILLYEI 426
>gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Homo
sapiens]
Length = 648
Score = 80.9 bits (198), Expect = 3e-15
Identities = 88/309 (28%), Positives = 139/309 (44%), Gaps = 35/309 (11%)
Query: 199 ARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRD---EQSWFRETEIYNTVLLRHDN 255
A +V L +G G +G V++G WHG+ VAVKI D EQ E+ RH N
Sbjct: 346 ASEVMLSTRIGSGSFGTVYKGKWHGD-VAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVN 404
Query: 256 ILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFL--QRQTLEPHLALRLAVSAACGLAHL 313
IL F+ MT N L ++T + E SLY L Q + + +A A G+ +L
Sbjct: 405 ILLFMGY-MTKDN----LAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYL 459
Query: 314 HVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTK 373
H + I HRD KS N+ + L I D GLA + S+ S + G+
Sbjct: 460 HAK--------NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQV--EQPTGSV 509
Query: 374 RYMAPEVLDEQIRTD-CFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPND 432
+MAPEV+ Q F+S D++++G+VL+E+ + + + R +V
Sbjct: 510 LWMAPEVIRMQDNNPFSFQS----DVYSYGIVLYELMTGELPYSHINN-RDQIIFMVGRG 564
Query: 433 PSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKI 492
+ D+ K+ + P RL AD V + ++E P + ++ +L KI
Sbjct: 565 YASPDLSKLY---KNCPKAMKRLVADCV-----KKVKEERPLFPQILSSIELLQHSLPKI 616
Query: 493 SNSPEKPKV 501
+ S +P +
Sbjct: 617 NRSASEPSL 625
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.432
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,774,242
Number of Sequences: 37866
Number of extensions: 971358
Number of successful extensions: 3578
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 170
Number of HSP's successfully gapped in prelim test: 517
Number of HSP's that attempted gapping in prelim test: 2604
Number of HSP's gapped (non-prelim): 793
length of query: 503
length of database: 18,247,518
effective HSP length: 107
effective length of query: 396
effective length of database: 14,195,856
effective search space: 5621558976
effective search space used: 5621558976
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.