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Search of human proteins with 116734708
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116734708 activin A receptor, type IIB precursor [Homo
sapiens]
(512 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116734708 activin A receptor, type IIB precursor [Homo sapiens] 1078 0.0
gi|4501897 activin A receptor, type IIA precursor [Homo sapiens] 754 0.0
gi|15451916 bone morphogenetic protein receptor type II precurso... 289 4e-78
gi|67782324 transforming growth factor, beta receptor II isoform... 279 5e-75
gi|67782326 transforming growth factor, beta receptor II isoform... 279 5e-75
gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens] 237 2e-62
gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens] 233 4e-61
gi|4502431 bone morphogenetic protein receptor, type IB precurso... 230 3e-60
gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens] 223 4e-58
gi|166235898 activin A receptor, type I precursor [Homo sapiens] 222 7e-58
gi|4501895 activin A receptor, type I precursor [Homo sapiens] 222 7e-58
gi|4759226 transforming growth factor, beta receptor I isoform 1... 221 1e-57
gi|195963412 transforming growth factor, beta receptor I isoform... 221 1e-57
gi|4757720 activin A receptor, type IB isoform a precursor [Homo... 218 1e-56
gi|41349437 bone morphogenetic protein receptor, type IA precurs... 210 3e-54
gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens] 210 3e-54
gi|116734714 activin A receptor type II-like 1 [Homo sapiens] 204 2e-52
gi|116734712 activin A receptor type II-like 1 [Homo sapiens] 204 2e-52
gi|33598910 activin A receptor, type IB isoform b precursor [Hom... 204 2e-52
gi|33598912 activin A receptor, type IB isoform c precursor [Hom... 173 4e-43
gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens] 165 8e-41
gi|40254844 receptor-interacting serine-threonine kinase 3 [Homo... 101 2e-21
gi|223671888 interleukin-1 receptor-associated kinase 4 isoform ... 93 7e-19
gi|223671885 interleukin-1 receptor-associated kinase 4 isoform ... 93 7e-19
gi|223671883 interleukin-1 receptor-associated kinase 4 isoform ... 93 7e-19
gi|166795293 interleukin-1 receptor-associated kinase 4 isoform ... 93 7e-19
gi|166795295 interleukin-1 receptor-associated kinase 4 isoform ... 93 7e-19
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 85 1e-16
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 85 1e-16
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 80 3e-15
>gi|116734708 activin A receptor, type IIB precursor [Homo sapiens]
Length = 512
Score = 1078 bits (2787), Expect = 0.0
Identities = 512/512 (100%), Positives = 512/512 (100%)
Query: 1 MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCY 60
MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCY
Sbjct: 1 MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCY 60
Query: 61 ASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAG 120
ASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAG
Sbjct: 61 ASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAG 120
Query: 121 GPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPP 180
GPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPP
Sbjct: 121 GPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPP 180
Query: 181 PSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMK 240
PSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMK
Sbjct: 181 PSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMK 240
Query: 241 HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSY 300
HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSY
Sbjct: 241 HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSY 300
Query: 301 LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVG 360
LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVG
Sbjct: 301 LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVG 360
Query: 361 TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ 420
TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ
Sbjct: 361 TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ 420
Query: 421 HPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSL 480
HPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSL
Sbjct: 421 HPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSL 480
Query: 481 IRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI 512
IRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
Sbjct: 481 IRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI 512
>gi|4501897 activin A receptor, type IIA precursor [Homo sapiens]
Length = 513
Score = 754 bits (1947), Expect = 0.0
Identities = 343/508 (67%), Positives = 431/508 (84%), Gaps = 2/508 (0%)
Query: 6 VALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRN 65
+A A+ S +G+ G +ET+EC+++NANWE +RTNQ+G+E C G++DKR HC+A+W+N
Sbjct: 7 LAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHCFATWKN 66
Query: 66 SSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAGGPEVT 125
SG+IE+VK+GCWLDD NCYDR +CV +++P+VYFCCCEGN CNE+F++ PE + T
Sbjct: 67 ISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPT 126
Query: 126 YEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIH-EDPGPPPPSPL 184
P P +L YSL+P+ ++ IV+ AFW+YRH K Y V + +DPGPPPPSPL
Sbjct: 127 SNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPL 186
Query: 185 VGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENL 244
+GLKPLQLLE+KARGRFGCVWKAQL+N++VAVKIFP+QDKQSWQ+E E++S PGMKHEN+
Sbjct: 187 LGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENI 246
Query: 245 LQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHED 304
LQFI AEKRG++++V+LWLITAFH+KGSL+D+LK N+++WNELCH+AETM+RGL+YLHED
Sbjct: 247 LQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHED 306
Query: 305 VPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRY 364
+P + +GHKP+I+HRD KSKNVLLK++LTA +ADFGLA++FE GK GDTHGQVGTRRY
Sbjct: 307 IPGLK-DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRY 365
Query: 365 MAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSL 424
MAPEVLEGAINFQRDAFLRIDMYAMGLVLWEL SRC AADGPVDEYMLPFEEEIGQHPSL
Sbjct: 366 MAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSL 425
Query: 425 EELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRS 484
E++QEVVVHKK RP ++D+W KH G+A LC TIEECWDHDAEARLSAGCV ER++ ++R
Sbjct: 426 EDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRL 485
Query: 485 VNGTTSDCLVSLVTSVTNVDLPPKESSI 512
N T++ +V++VT VTNVD PPKESS+
Sbjct: 486 TNIITTEDIVTVVTMVTNVDFPPKESSL 513
>gi|15451916 bone morphogenetic protein receptor type II precursor
[Homo sapiens]
Length = 1038
Score = 289 bits (740), Expect = 4e-78
Identities = 178/502 (35%), Positives = 271/502 (53%), Gaps = 37/502 (7%)
Query: 4 PWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQ--DKRLHCYA 61
PW+ +L S A S E R C + + + +S + G K CY
Sbjct: 12 PWLPWTILLVSTAAASQNQE---RLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYG 68
Query: 62 SWRNSSGTIELVKKGCWL---DDFNCYDRQECVATEENPQVY-----FCCCEGNFCNERF 113
W S G I LVK+GCW D C+ +ECV T P + FCCC + CN F
Sbjct: 69 LWEKSKGDINLVKQGCWSHIGDPQECH-YEECVVTTTPPSIQNGTYRFCCCSTDLCNVNF 127
Query: 114 THLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYR----HRKPPYGH 169
T P+ T PP + + +L + L+++++ + YR RK
Sbjct: 128 TE--NFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRKQGLHS 185
Query: 170 VDIHEDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQS 229
+++ E P L LK LLE+ RGR+G V+K L VAVK+F ++Q++ +
Sbjct: 186 MNMMEAAASEPSLDLDNLK---LLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFIN 242
Query: 230 EREIFSTPGMKHENLLQFIAAEKR-GSNLEVELWLITAFHDKGSLTDYLKGNIITWNELC 288
E+ I+ P M+H+N+ +FI ++R ++ +E L+ ++ GSL YL + W C
Sbjct: 243 EKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSC 302
Query: 289 HVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRF-- 346
+A +++RGL+YLH ++P RG+ +KP+I+HRD S+NVL+K+D T V++DFGL++R
Sbjct: 303 RLAHSVTRGLAYLHTELP--RGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTG 360
Query: 347 ----EPGKPPGDTHGQVGTRRYMAPEVLEGAINFQ--RDAFLRIDMYAMGLVLWELVSRC 400
PG+ +VGT RYMAPEVLEGA+N + A ++DMYA+GL+ WE+ RC
Sbjct: 361 NRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRC 420
Query: 401 K--AADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHP-GLAQLCVTI 457
V EY + F+ E+G HP+ E++Q +V +K RP + W ++ + L TI
Sbjct: 421 TDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETI 480
Query: 458 EECWDHDAEARLSAGCVEERVS 479
E+CWD DAEARL+A C EER++
Sbjct: 481 EDCWDQDAEARLTAQCAEERMA 502
>gi|67782324 transforming growth factor, beta receptor II isoform B
precursor [Homo sapiens]
Length = 567
Score = 279 bits (713), Expect = 5e-75
Identities = 175/475 (36%), Positives = 253/475 (53%), Gaps = 56/475 (11%)
Query: 49 CEGEQDKRLHCYASWRNSSGTIELVKKGCW-----LDDFNCYDRQ--ECVATEENPQ--- 98
CE Q+ C A WR + I L + C DF D +C+ E+
Sbjct: 77 CEKPQEV---CVAVWRKNDENITL-ETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGET 132
Query: 99 VYFCCCEGNFCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFW 158
+ C C + CN+ E P + V SLLP G+++ V++ F+
Sbjct: 133 FFMCSCSSDECNDNIIF-----SEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFY 187
Query: 159 MYR-HRKPPYGHV-----------------DIHEDPGPPPPSPLVG-------LKPLQLL 193
YR +R+ I ED S L P++L
Sbjct: 188 CYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELD 247
Query: 194 EIKARGRFGCVWKAQLMN------DFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQF 247
+ +GRF V+KA+L + VAVKIFP ++ SW++E++IFS +KHEN+LQF
Sbjct: 248 TLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQF 307
Query: 248 IAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPW 307
+ AE+R + L + WLITAFH KG+L +YL ++I+W +L + +++RG+++LH D
Sbjct: 308 LTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTP 367
Query: 308 CRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYM 365
C G P I HRD KS N+L+K+DLT L DFGL++R +P D GQVGT RYM
Sbjct: 368 C-GRPKMP-IVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYM 425
Query: 366 APEVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSL 424
APEVLE +N + ++F + D+Y+M LVLWE+ SRC A G V +Y PF ++ +HP +
Sbjct: 426 APEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAV-GEVKDYEPPFGSKVREHPCV 484
Query: 425 EELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVS 479
E +++ V+ + RP I WL H G+ +C T+ ECWDHD EARL+A CV ER S
Sbjct: 485 ESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFS 539
>gi|67782326 transforming growth factor, beta receptor II isoform A
precursor [Homo sapiens]
Length = 592
Score = 279 bits (713), Expect = 5e-75
Identities = 175/475 (36%), Positives = 253/475 (53%), Gaps = 56/475 (11%)
Query: 49 CEGEQDKRLHCYASWRNSSGTIELVKKGCW-----LDDFNCYDRQ--ECVATEENPQ--- 98
CE Q+ C A WR + I L + C DF D +C+ E+
Sbjct: 102 CEKPQEV---CVAVWRKNDENITL-ETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGET 157
Query: 99 VYFCCCEGNFCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFW 158
+ C C + CN+ E P + V SLLP G+++ V++ F+
Sbjct: 158 FFMCSCSSDECNDNIIF-----SEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFY 212
Query: 159 MYR-HRKPPYGHV-----------------DIHEDPGPPPPSPLVG-------LKPLQLL 193
YR +R+ I ED S L P++L
Sbjct: 213 CYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELD 272
Query: 194 EIKARGRFGCVWKAQLMN------DFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQF 247
+ +GRF V+KA+L + VAVKIFP ++ SW++E++IFS +KHEN+LQF
Sbjct: 273 TLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQF 332
Query: 248 IAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPW 307
+ AE+R + L + WLITAFH KG+L +YL ++I+W +L + +++RG+++LH D
Sbjct: 333 LTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTP 392
Query: 308 CRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYM 365
C G P I HRD KS N+L+K+DLT L DFGL++R +P D GQVGT RYM
Sbjct: 393 C-GRPKMP-IVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYM 450
Query: 366 APEVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSL 424
APEVLE +N + ++F + D+Y+M LVLWE+ SRC A G V +Y PF ++ +HP +
Sbjct: 451 APEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAV-GEVKDYEPPFGSKVREHPCV 509
Query: 425 EELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVS 479
E +++ V+ + RP I WL H G+ +C T+ ECWDHD EARL+A CV ER S
Sbjct: 510 ESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFS 564
>gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens]
Length = 493
Score = 237 bits (605), Expect = 2e-62
Identities = 153/459 (33%), Positives = 240/459 (52%), Gaps = 59/459 (12%)
Query: 59 CYASWRNSSGTIELVKKGCWLDDFN----CYDRQECVATEENPQVYFCCCEGNFCNERFT 114
C+AS ++G +++K L + N C+ TE CC +FCN
Sbjct: 46 CWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTE--------CCFTDFCNNITL 97
Query: 115 HLPEAGGPEVTYEPPPTAPTL--LTVLAYSLLPIGGLSLIVLLAFWM-------YRHRKP 165
HLP A P AP L + + +P+ LS+ +L W YR +K
Sbjct: 98 HLPTAS---------PNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKR 148
Query: 166 PYGHVDIHE----------------------DPGPPPPSPLVGLKPLQLLEIKARGRFGC 203
P + E G P + + L EI +GRFG
Sbjct: 149 PNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGE 208
Query: 204 VWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWL 263
VW + + VAVKIF +D++SW E EI+ T ++HEN+L FIAA+ + + +LWL
Sbjct: 209 VWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWL 268
Query: 264 ITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFK 323
++ +H++GSL DYL NI+T + +A +++ GL++LH ++ +G KP+IAHRD K
Sbjct: 269 VSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQG---KPAIAHRDIK 325
Query: 324 SKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAPEVLEGAINFQ-RDA 380
SKN+L+K T +AD GLAV+ + D + +VGT+RYMAPE+L+ +N ++
Sbjct: 326 SKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFES 385
Query: 381 FLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTI 440
F R D+Y++GLV WE+ RC + G V+EY LP+ + + PS+EE+++VV +K RP+I
Sbjct: 386 FKRADIYSVGLVYWEIARRC-SVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSI 444
Query: 441 KDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVS 479
+ W L + + ECW + ARL+A +++ +S
Sbjct: 445 PNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTIS 483
>gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens]
Length = 443
Score = 233 bits (593), Expect = 4e-61
Identities = 148/436 (33%), Positives = 229/436 (52%), Gaps = 57/436 (13%)
Query: 88 QECVATEENPQVYFC----------CCEGNFCNERFTHLPEAGGPEVTYEPPPTAPTL-- 135
+ CV+ E FC CC +FCN HLP A P AP L
Sbjct: 11 KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTAS---------PNAPKLGP 61
Query: 136 LTVLAYSLLPIGGLSLIVLLAFWM-------YRHRKPPYGHVDIHE-------------- 174
+ + +P+ LS+ +L W YR +K P + E
Sbjct: 62 MELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLI 121
Query: 175 --------DPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQS 226
G P + + L EI +GRFG VW + + VAVKIF +D++S
Sbjct: 122 YDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERS 181
Query: 227 WQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNE 286
W E EI+ T ++HEN+L FIAA+ + + +LWL++ +H++GSL DYL NI+T
Sbjct: 182 WFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAG 241
Query: 287 LCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRF 346
+ +A +++ GL++LH ++ +G KP+IAHRD KSKN+L+K T +AD GLAV+
Sbjct: 242 MIKLALSIASGLAHLHMEIVGTQG---KPAIAHRDIKSKNILVKKCETCAIADLGLAVKH 298
Query: 347 EPGKPPGD--THGQVGTRRYMAPEVLEGAINFQ-RDAFLRIDMYAMGLVLWELVSRCKAA 403
+ D + +VGT+RYMAPE+L+ +N ++F R D+Y++GLV WE+ RC +
Sbjct: 299 DSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRC-SV 357
Query: 404 DGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDH 463
G V+EY LP+ + + PS+EE+++VV +K RP+I + W L + + ECW
Sbjct: 358 GGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYA 417
Query: 464 DAEARLSAGCVEERVS 479
+ ARL+A +++ +S
Sbjct: 418 NGAARLTALRIKKTIS 433
>gi|4502431 bone morphogenetic protein receptor, type IB precursor
[Homo sapiens]
Length = 502
Score = 230 bits (586), Expect = 3e-60
Identities = 151/461 (32%), Positives = 239/461 (51%), Gaps = 49/461 (10%)
Query: 58 HCYASWRNSSGTIELVKKGCWL---DDFNCYDRQECVATEENPQVYFCCCEGNFCNERF- 113
+C+ + +V GC DF C D + CC E N CN+
Sbjct: 52 YCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRD----TPIPHQRRSIECCTERNECNKDLH 107
Query: 114 THLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKP-PYGHVDI 172
LP + P L++V SLL L LI+L ++ Y+ ++ P + +
Sbjct: 108 PTLPPLKNRDFVDGPIHHRALLISVTVCSLL----LVLIILFCYFRYKRQETRPRYSIGL 163
Query: 173 HEDPGPPPPSPLV--------------GL---------KPLQLLEIKARGRFGCVWKAQL 209
+D PP + GL K +Q+++ +GR+G VW +
Sbjct: 164 EQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKW 223
Query: 210 MNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHD 269
+ VAVK+F ++ SW E EI+ T M+HEN+L FIAA+ +G+ +L+LIT +H+
Sbjct: 224 RGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHE 283
Query: 270 KGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLL 329
GSL DYLK + + +A + GL +LH ++ +G KP+IAHRD KSKN+L+
Sbjct: 284 NGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQG---KPAIAHRDLKSKNILV 340
Query: 330 KSDLTAVLADFGLAVRF-----EPGKPPGDTHGQVGTRRYMAPEVLEGAINFQR-DAFLR 383
K + T +AD GLAV+F E PP + +VGT+RYM PEVL+ ++N +++
Sbjct: 341 KKNGTCCIADLGLAVKFISDTNEVDIPP---NTRVGTKRYMPPEVLDESLNRNHFQSYIM 397
Query: 384 IDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDH 443
DMY+ GL+LWE+ RC + G V+EY LP+ + + PS E+++E+V KK+RP+ +
Sbjct: 398 ADMYSFGLILWEVARRC-VSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNR 456
Query: 444 WLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRS 484
W L Q+ + ECW H+ +RL+A V++ ++ + S
Sbjct: 457 WSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSES 497
>gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens]
Length = 413
Score = 223 bits (567), Expect = 4e-58
Identities = 121/314 (38%), Positives = 194/314 (61%), Gaps = 7/314 (2%)
Query: 169 HVDIHEDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQ 228
++ +H G P + + L EI +GRFG VW + + VAVKIF +D++SW
Sbjct: 94 NITLHLPTGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWF 153
Query: 229 SEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELC 288
E EI+ T ++HEN+L FIAA+ + + +LWL++ +H++GSL DYL NI+T +
Sbjct: 154 REAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMI 213
Query: 289 HVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEP 348
+A +++ GL++LH ++ +G KP+IAHRD KSKN+L+K T +AD GLAV+ +
Sbjct: 214 KLALSIASGLAHLHMEIVGTQG---KPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDS 270
Query: 349 GKPPGD--THGQVGTRRYMAPEVLEGAINFQ-RDAFLRIDMYAMGLVLWELVSRCKAADG 405
D + +VGT+RYMAPE+L+ +N ++F R D+Y++GLV WE+ RC + G
Sbjct: 271 ILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRC-SVGG 329
Query: 406 PVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDA 465
V+EY LP+ + + PS+EE+++VV +K RP+I + W L + + ECW +
Sbjct: 330 IVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANG 389
Query: 466 EARLSAGCVEERVS 479
ARL+A +++ +S
Sbjct: 390 AARLTALRIKKTIS 403
>gi|166235898 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 222 bits (565), Expect = 7e-58
Identities = 155/483 (32%), Positives = 250/483 (51%), Gaps = 56/483 (11%)
Query: 47 ERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVA-TEENPQVYFCCCE 105
+ CEG+Q C++S + G + +KGC F Y++ + T +P CC+
Sbjct: 46 DHCEGQQ-----CFSSLSINDG-FHVYQKGC----FQVYEQGKMTCKTPPSPGQAVECCQ 95
Query: 106 GNFCNERFT-HLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLL---AFWMYR 161
G++CN T LP G P T L V L + + L+ L A ++
Sbjct: 96 GDWCNRNITAQLPTKGKSF-----PGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFK 150
Query: 162 HRKPP--------YGHVD--IHEDPGPPPPSPLV----------GL---------KPLQL 192
R YG ++ I + G + L+ GL + + L
Sbjct: 151 RRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITL 210
Query: 193 LEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEK 252
LE +GR+G VW+ + VAVKIF +D++SW E E+++T ++HEN+L FIA++
Sbjct: 211 LECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDM 270
Query: 253 RGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEG 312
+ +LWLIT +H+ GSL DYL+ + + +++ GL++LH ++ +G
Sbjct: 271 TSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQG-- 328
Query: 313 HKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAPEVL 370
KP+IAHRD KSKN+L+K + +AD GLAV D + +VGT+RYMAPEVL
Sbjct: 329 -KPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVL 387
Query: 371 EGAINFQ-RDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQE 429
+ I D++ R+D++A GLVLWE V+R ++G V++Y PF + + PS E++++
Sbjct: 388 DETIQVDCFDSYKRVDIWAFGLVLWE-VARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRK 446
Query: 430 VVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTT 489
VV + RP I + W P L L ++ECW + ARL+A +++ ++ I S++
Sbjct: 447 VVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLK 506
Query: 490 SDC 492
+DC
Sbjct: 507 TDC 509
>gi|4501895 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 222 bits (565), Expect = 7e-58
Identities = 155/483 (32%), Positives = 250/483 (51%), Gaps = 56/483 (11%)
Query: 47 ERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVA-TEENPQVYFCCCE 105
+ CEG+Q C++S + G + +KGC F Y++ + T +P CC+
Sbjct: 46 DHCEGQQ-----CFSSLSINDG-FHVYQKGC----FQVYEQGKMTCKTPPSPGQAVECCQ 95
Query: 106 GNFCNERFT-HLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLL---AFWMYR 161
G++CN T LP G P T L V L + + L+ L A ++
Sbjct: 96 GDWCNRNITAQLPTKGKSF-----PGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFK 150
Query: 162 HRKPP--------YGHVD--IHEDPGPPPPSPLV----------GL---------KPLQL 192
R YG ++ I + G + L+ GL + + L
Sbjct: 151 RRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITL 210
Query: 193 LEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEK 252
LE +GR+G VW+ + VAVKIF +D++SW E E+++T ++HEN+L FIA++
Sbjct: 211 LECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDM 270
Query: 253 RGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEG 312
+ +LWLIT +H+ GSL DYL+ + + +++ GL++LH ++ +G
Sbjct: 271 TSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQG-- 328
Query: 313 HKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAPEVL 370
KP+IAHRD KSKN+L+K + +AD GLAV D + +VGT+RYMAPEVL
Sbjct: 329 -KPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVL 387
Query: 371 EGAINFQ-RDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQE 429
+ I D++ R+D++A GLVLWE V+R ++G V++Y PF + + PS E++++
Sbjct: 388 DETIQVDCFDSYKRVDIWAFGLVLWE-VARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRK 446
Query: 430 VVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTT 489
VV + RP I + W P L L ++ECW + ARL+A +++ ++ I S++
Sbjct: 447 VVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLK 506
Query: 490 SDC 492
+DC
Sbjct: 507 TDC 509
>gi|4759226 transforming growth factor, beta receptor I isoform 1
precursor [Homo sapiens]
Length = 503
Score = 221 bits (563), Expect = 1e-57
Identities = 117/295 (39%), Positives = 186/295 (63%), Gaps = 7/295 (2%)
Query: 188 KPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQF 247
+ + L E +GRFG VW+ + + VAVKIF ++++SW E EI+ T ++HEN+L F
Sbjct: 203 RTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGF 262
Query: 248 IAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPW 307
IAA+ + + +LWL++ +H+ GSL DYL +T + +A + + GL++LH ++
Sbjct: 263 IAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVG 322
Query: 308 CRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYM 365
+G KP+IAHRD KSKN+L+K + T +AD GLAVR + D + +VGT+RYM
Sbjct: 323 TQG---KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYM 379
Query: 366 APEVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSL 424
APEVL+ +IN + ++F R D+YAMGLV WE+ RC + G ++Y LP+ + + PS+
Sbjct: 380 APEVLDDSINMKHFESFKRADIYAMGLVFWEIARRC-SIGGIHEDYQLPYYDLVPSDPSV 438
Query: 425 EELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVS 479
EE+++VV +K+RP I + W L + + ECW + ARL+A +++ +S
Sbjct: 439 EEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLS 493
>gi|195963412 transforming growth factor, beta receptor I isoform 2
precursor [Homo sapiens]
Length = 426
Score = 221 bits (563), Expect = 1e-57
Identities = 117/295 (39%), Positives = 186/295 (63%), Gaps = 7/295 (2%)
Query: 188 KPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQF 247
+ + L E +GRFG VW+ + + VAVKIF ++++SW E EI+ T ++HEN+L F
Sbjct: 126 RTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGF 185
Query: 248 IAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPW 307
IAA+ + + +LWL++ +H+ GSL DYL +T + +A + + GL++LH ++
Sbjct: 186 IAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVG 245
Query: 308 CRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYM 365
+G KP+IAHRD KSKN+L+K + T +AD GLAVR + D + +VGT+RYM
Sbjct: 246 TQG---KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYM 302
Query: 366 APEVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSL 424
APEVL+ +IN + ++F R D+YAMGLV WE+ RC + G ++Y LP+ + + PS+
Sbjct: 303 APEVLDDSINMKHFESFKRADIYAMGLVFWEIARRC-SIGGIHEDYQLPYYDLVPSDPSV 361
Query: 425 EELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVS 479
EE+++VV +K+RP I + W L + + ECW + ARL+A +++ +S
Sbjct: 362 EEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLS 416
>gi|4757720 activin A receptor, type IB isoform a precursor [Homo
sapiens]
Length = 505
Score = 218 bits (555), Expect = 1e-56
Identities = 140/422 (33%), Positives = 227/422 (53%), Gaps = 42/422 (9%)
Query: 90 CVATEENPQVYFCCCEGNFCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGL 149
C+++E+ + CC ++CN +P +G + P P L + P+ L
Sbjct: 84 CLSSEDLRNTH--CCYTDYCNRIDLRVP-SGHLKEPEHPSMWGPVELVGIIAG--PVFLL 138
Query: 150 SLIVLLAFWMYRHRKPPYGH---VDIHEDP--------------------------GPPP 180
LI+++ F + + + Y + +D+ EDP G P
Sbjct: 139 FLIIIIVFLVINYHQRVYHNRQRLDM-EDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPL 197
Query: 181 PSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMK 240
+ + L EI +GRFG VW+ + VAVKIF ++++SW E EI+ T ++
Sbjct: 198 FVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLR 257
Query: 241 HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSY 300
HEN+L FIAA+ + + +LWL++ +H+ GSL DYL +T + +A + + GL++
Sbjct: 258 HENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAH 317
Query: 301 LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQ 358
LH ++ +G KP IAHRD KSKN+L+K + +AD GLAVR + D + +
Sbjct: 318 LHMEIVGTQG---KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQR 374
Query: 359 VGTRRYMAPEVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEE 417
VGT+RYMAPEVL+ IN + D+F D+YA+GLV WE+ RC + G +EY LP+ +
Sbjct: 375 VGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG-GVHEEYQLPYYDL 433
Query: 418 IGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEER 477
+ PS+EE+++VV +K+RP I + W + L + + ECW + ARL+A +++
Sbjct: 434 VPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKT 493
Query: 478 VS 479
+S
Sbjct: 494 LS 495
>gi|41349437 bone morphogenetic protein receptor, type IA precursor
[Homo sapiens]
Length = 532
Score = 210 bits (534), Expect = 3e-54
Identities = 111/287 (38%), Positives = 175/287 (60%), Gaps = 7/287 (2%)
Query: 188 KPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQF 247
K +Q++ +GR+G VW + + VAVK+F ++ SW E EI+ T M+HEN+L F
Sbjct: 232 KQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGF 291
Query: 248 IAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPW 307
IAA+ +G+ +L+LIT +H+ GSL D+LK + L +A + + GL +LH ++
Sbjct: 292 IAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYG 351
Query: 308 CRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDT--HGQVGTRRYM 365
+G KP+IAHRD KSKN+L+K + + +AD GLAV+F D + +VGT+RYM
Sbjct: 352 TQG---KPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYM 408
Query: 366 APEVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSL 424
APEVL+ ++N ++ D+Y+ GL++WE+ RC G V+EY LP+ + PS
Sbjct: 409 APEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRC-ITGGIVEEYQLPYYNMVPSDPSY 467
Query: 425 EELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSA 471
E+++EVV K++RP + + W L + + ECW H+ +RL+A
Sbjct: 468 EDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTA 514
>gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens]
Length = 573
Score = 210 bits (534), Expect = 3e-54
Identities = 145/457 (31%), Positives = 226/457 (49%), Gaps = 43/457 (9%)
Query: 59 CYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEE-----NPQVYFCCCEGNFCNERF 113
C+ W + ++ +GC D + C + ++ C C +FCN +
Sbjct: 61 CFGIWNLTQDRAQVEMQGCRDSDEPGCESLHCDPSPRAHPSPGSTLFTCSCGTDFCNANY 120
Query: 114 THLPEAGGPEVT-YEPPPTAP--------TLLTVLAYSLLPIGGLSLIVLLAFWMYRHRK 164
+HLP G P + P AP LL + LL +G + ++ LL YR R
Sbjct: 121 SHLPPPGSPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLGSI-ILALLQRKNYRVRG 179
Query: 165 PPYGHVDIHEDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDK 224
P + D G L L L ++ G VW QL VA+K FP +
Sbjct: 180 EPVP--EPRPDSGRDWSVELQELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSV 237
Query: 225 QSWQSEREIFSTPGMKHENLLQFIAAEKRG-SNLEVELWLITAFHDKGSLTDYLKGNIIT 283
+Q+ER ++ PG++H+++++FI A + G L L+ H KGSL YL
Sbjct: 238 AQFQAERALYELPGLQHDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSD 297
Query: 284 WNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLA 343
W +A ++++GL++LHE+ W G+ +KP IAHRD S+NVL++ D + + D GLA
Sbjct: 298 WGSSLRMALSLAQGLAFLHEE-RWQNGQ-YKPGIAHRDLSSQNVLIREDGSCAIGDLGLA 355
Query: 344 VRFEPG--KPPGDTHGQ---------VGTRRYMAPEVLEGAINFQ--RDAFLRIDMYAMG 390
+ PG +PP T Q GT+RYMAPE+L+ ++ Q A R D+Y++
Sbjct: 356 LVL-PGLTQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLA 414
Query: 391 LVLWELVSRCK--AADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHW---- 444
L+LWE++SRC D + L +E E+G P+ +EL + V ++ RP I W
Sbjct: 415 LLLWEILSRCPDLRPDSSPPPFQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWRCFA 474
Query: 445 LKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLI 481
GL +L +E+CWD D EARL+A CV++R++ +
Sbjct: 475 TDPDGLREL---LEDCWDADPEARLTAECVQQRLAAL 508
>gi|116734714 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 204 bits (519), Expect = 2e-52
Identities = 137/414 (33%), Positives = 216/414 (52%), Gaps = 39/414 (9%)
Query: 103 CCEGNFCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRH 162
CC+ + CN + + EA P E P T L +L +L + L + +L W R
Sbjct: 89 CCDSHLCNHNVSLVLEATQPPS--EQPGTDGQLALILG-PVLALLALVALGVLGLWHVRR 145
Query: 163 RKPPYG--HVDIHEDP---------------------------GPPPPSPLVGLKPLQLL 193
R+ H ++ E G P + + L+
Sbjct: 146 RQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALV 205
Query: 194 EIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKR 253
E +GR+G VW+ + VAVKIF +D+QSW E EI++T ++H+N+L FIA++
Sbjct: 206 ECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMT 265
Query: 254 GSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGH 313
N +LWLIT +H+ GSL D+L+ + + +A + + GL++LH ++ +G
Sbjct: 266 SRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQG--- 322
Query: 314 KPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAPEVLE 371
KP+IAHRDFKS+NVL+KS+L +AD GLAV G D + +VGT+RYMAPEVL+
Sbjct: 323 KPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLD 382
Query: 372 GAINFQ-RDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEV 430
I +++ D++A GLVLWE ++R +G V++Y PF + + PS E++++V
Sbjct: 383 EQIRTDCFESYKWTDIWAFGLVLWE-IARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKV 441
Query: 431 VVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRS 484
V + PTI + P L+ L + ECW + ARL+A +++ + I S
Sbjct: 442 VCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNS 495
>gi|116734712 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 204 bits (519), Expect = 2e-52
Identities = 137/414 (33%), Positives = 216/414 (52%), Gaps = 39/414 (9%)
Query: 103 CCEGNFCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRH 162
CC+ + CN + + EA P E P T L +L +L + L + +L W R
Sbjct: 89 CCDSHLCNHNVSLVLEATQPPS--EQPGTDGQLALILG-PVLALLALVALGVLGLWHVRR 145
Query: 163 RKPPYG--HVDIHEDP---------------------------GPPPPSPLVGLKPLQLL 193
R+ H ++ E G P + + L+
Sbjct: 146 RQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALV 205
Query: 194 EIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKR 253
E +GR+G VW+ + VAVKIF +D+QSW E EI++T ++H+N+L FIA++
Sbjct: 206 ECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMT 265
Query: 254 GSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGH 313
N +LWLIT +H+ GSL D+L+ + + +A + + GL++LH ++ +G
Sbjct: 266 SRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQG--- 322
Query: 314 KPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAPEVLE 371
KP+IAHRDFKS+NVL+KS+L +AD GLAV G D + +VGT+RYMAPEVL+
Sbjct: 323 KPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLD 382
Query: 372 GAINFQ-RDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEV 430
I +++ D++A GLVLWE ++R +G V++Y PF + + PS E++++V
Sbjct: 383 EQIRTDCFESYKWTDIWAFGLVLWE-IARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKV 441
Query: 431 VVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRS 484
V + PTI + P L+ L + ECW + ARL+A +++ + I S
Sbjct: 442 VCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNS 495
>gi|33598910 activin A receptor, type IB isoform b precursor [Homo
sapiens]
Length = 476
Score = 204 bits (518), Expect = 2e-52
Identities = 131/387 (33%), Positives = 209/387 (54%), Gaps = 42/387 (10%)
Query: 90 CVATEENPQVYFCCCEGNFCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGL 149
C+++E+ + CC ++CN +P +G + P P L + P+ L
Sbjct: 84 CLSSEDLRNTH--CCYTDYCNRIDLRVP-SGHLKEPEHPSMWGPVELVGIIAG--PVFLL 138
Query: 150 SLIVLLAFWMYRHRKPPYGH---VDIHEDP--------------------------GPPP 180
LI+++ F + + + Y + +D+ EDP G P
Sbjct: 139 FLIIIIVFLVINYHQRVYHNRQRLDM-EDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPL 197
Query: 181 PSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMK 240
+ + L EI +GRFG VW+ + VAVKIF ++++SW E EI+ T ++
Sbjct: 198 FVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLR 257
Query: 241 HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSY 300
HEN+L FIAA+ + + +LWL++ +H+ GSL DYL +T + +A + + GL++
Sbjct: 258 HENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAH 317
Query: 301 LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQ 358
LH ++ +G KP IAHRD KSKN+L+K + +AD GLAVR + D + +
Sbjct: 318 LHMEIVGTQG---KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQR 374
Query: 359 VGTRRYMAPEVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEE 417
VGT+RYMAPEVL+ IN + D+F D+YA+GLV WE+ RC + G +EY LP+ +
Sbjct: 375 VGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG-GVHEEYQLPYYDL 433
Query: 418 IGQHPSLEELQEVVVHKKMRPTIKDHW 444
+ PS+EE+++VV +K+RP I + W
Sbjct: 434 VPSDPSIEEMRKVVCDQKLRPNIPNWW 460
>gi|33598912 activin A receptor, type IB isoform c precursor [Homo
sapiens]
Length = 487
Score = 173 bits (438), Expect = 4e-43
Identities = 115/345 (33%), Positives = 182/345 (52%), Gaps = 41/345 (11%)
Query: 90 CVATEENPQVYFCCCEGNFCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGL 149
C+++E+ + CC ++CN +P +G + P P L + P+ L
Sbjct: 84 CLSSEDLRNTH--CCYTDYCNRIDLRVP-SGHLKEPEHPSMWGPVELVGIIAG--PVFLL 138
Query: 150 SLIVLLAFWMYRHRKPPYGH---VDIHEDP--------------------------GPPP 180
LI+++ F + + + Y + +D+ EDP G P
Sbjct: 139 FLIIIIVFLVINYHQRVYHNRQRLDM-EDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPL 197
Query: 181 PSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMK 240
+ + L EI +GRFG VW+ + VAVKIF ++++SW E EI+ T ++
Sbjct: 198 FVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLR 257
Query: 241 HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSY 300
HEN+L FIAA+ + + +LWL++ +H+ GSL DYL +T + +A + + GL++
Sbjct: 258 HENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAH 317
Query: 301 LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQ 358
LH ++ +G KP IAHRD KSKN+L+K + +AD GLAVR + D + +
Sbjct: 318 LHMEIVGTQG---KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQR 374
Query: 359 VGTRRYMAPEVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCKA 402
VGT+RYMAPEVL+ IN + D+F D+YA+GLV WE+ RC +
Sbjct: 375 VGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNS 419
>gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens]
Length = 336
Score = 165 bits (418), Expect = 8e-41
Identities = 88/223 (39%), Positives = 142/223 (63%), Gaps = 7/223 (3%)
Query: 260 ELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAH 319
+LWL++ +H++GSL DYL NI+T + +A +++ GL++LH ++ +G KP+IAH
Sbjct: 108 QLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQG---KPAIAH 164
Query: 320 RDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDT--HGQVGTRRYMAPEVLEGAINFQ 377
RD KSKN+L+K T +AD GLAV+ + D + +VGT+RYMAPE+L+ +N
Sbjct: 165 RDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVN 224
Query: 378 R-DAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKM 436
++F R D+Y++GLV WE+ RC G V+EY LP+ + + PS+EE+++VV +K
Sbjct: 225 IFESFKRADIYSVGLVYWEIARRCSVG-GIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKF 283
Query: 437 RPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVS 479
RP+I + W L + + ECW + ARL+A +++ +S
Sbjct: 284 RPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTIS 326
Score = 30.0 bits (66), Expect = 5.2
Identities = 19/67 (28%), Positives = 28/67 (41%), Gaps = 12/67 (17%)
Query: 59 CYASWRNSSGTIELVKKGCWLDDFN----CYDRQECVATEENPQVYFCCCEGNFCNERFT 114
C+AS ++G +++K L + N C+ TE CC +FCN
Sbjct: 46 CWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTE--------CCFTDFCNNITL 97
Query: 115 HLPEAGG 121
HLP G
Sbjct: 98 HLPTDNG 104
>gi|40254844 receptor-interacting serine-threonine kinase 3 [Homo
sapiens]
Length = 518
Score = 101 bits (251), Expect = 2e-21
Identities = 97/341 (28%), Positives = 160/341 (46%), Gaps = 49/341 (14%)
Query: 181 PSPLVGLKPLQLLEIKARGRFGCVWKAQ--LMNDFVAVKIFPLQDKQSWQSEREIFSTPG 238
P+PLV ++ L+ E+ +G FG V++AQ VAVKI S RE+ +
Sbjct: 12 PAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIV-----NSKAISREVKAMAS 66
Query: 239 MKHENLLQFIAA-EKRGSNLEVELWLITAFHDKGSLTDYLKGNIIT-WNELCHVAETMSR 296
+ +E +L+ EK + + + L+T F + GSL+ L+ W LC + + +
Sbjct: 67 LDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVL 126
Query: 297 GLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTH 356
G+ YLH+ P + HRD K NVLL +L LADFGL+ F+ G G
Sbjct: 127 GMFYLHDQ---------NPVLLHRDLKPSNVLLDPELHVKLADFGLST-FQGGSQSGTGS 176
Query: 357 GQV-GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFE 415
G+ GT Y+APE+ +N R A D+Y+ G+++W +++ E
Sbjct: 177 GEPGGTLGYLAPELF---VNVNRKASTASDVYSFGILMWAVLA--------------GRE 219
Query: 416 EEIGQHPSLEELQEVVVHKKMRPTIKD---HWLKHPGLAQLCVTIEECWDHDAEARLS-A 471
E+ PSL + E V +++ RP++ + + PGL L ++ CW + + R S
Sbjct: 220 VELPTEPSL--VYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQ 277
Query: 472 GCV---EERVSLIRRSVN---GTTSDCLVSLVTSVTNVDLP 506
C+ +E ++ ++N T D L L +S +P
Sbjct: 278 ECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIP 318
>gi|223671888 interleukin-1 receptor-associated kinase 4 isoform b
[Homo sapiens]
Length = 336
Score = 92.8 bits (229), Expect = 7e-19
Identities = 77/248 (31%), Positives = 116/248 (46%), Gaps = 34/248 (13%)
Query: 199 GRFGCVWKAQLMNDFVAVKIFPLQ-----DKQSWQSEREIFSTPGMKHENLLQFIAAEKR 253
G FG V+K + N VAVK ++ Q ++EI +HENL++ +
Sbjct: 71 GGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSD 130
Query: 254 GSNLEVELWLITAFHDKGSLTDYLK----GNIITWNELCHVAETMSRGLSYLHEDVPWCR 309
G +L L+ + GSL D L ++W+ C +A+ + G+++LHE+
Sbjct: 131 GD----DLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHEN----- 181
Query: 310 GEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEV 369
HRD KS N+LL TA ++DFGLA E T VGT YMAPE
Sbjct: 182 ------HHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEA 235
Query: 370 LEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVD-EYMLPFEEEIGQHPSLEELQ 428
L G I + D+Y+ G+VL E+++ A D + + +L +EEI E+
Sbjct: 236 LRGEIT------PKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDE---EKTI 286
Query: 429 EVVVHKKM 436
E + KKM
Sbjct: 287 EDYIDKKM 294
>gi|223671885 interleukin-1 receptor-associated kinase 4 isoform b
[Homo sapiens]
Length = 336
Score = 92.8 bits (229), Expect = 7e-19
Identities = 77/248 (31%), Positives = 116/248 (46%), Gaps = 34/248 (13%)
Query: 199 GRFGCVWKAQLMNDFVAVKIFPLQ-----DKQSWQSEREIFSTPGMKHENLLQFIAAEKR 253
G FG V+K + N VAVK ++ Q ++EI +HENL++ +
Sbjct: 71 GGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSD 130
Query: 254 GSNLEVELWLITAFHDKGSLTDYLK----GNIITWNELCHVAETMSRGLSYLHEDVPWCR 309
G +L L+ + GSL D L ++W+ C +A+ + G+++LHE+
Sbjct: 131 GD----DLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHEN----- 181
Query: 310 GEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEV 369
HRD KS N+LL TA ++DFGLA E T VGT YMAPE
Sbjct: 182 ------HHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEA 235
Query: 370 LEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVD-EYMLPFEEEIGQHPSLEELQ 428
L G I + D+Y+ G+VL E+++ A D + + +L +EEI E+
Sbjct: 236 LRGEIT------PKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDE---EKTI 286
Query: 429 EVVVHKKM 436
E + KKM
Sbjct: 287 EDYIDKKM 294
>gi|223671883 interleukin-1 receptor-associated kinase 4 isoform b
[Homo sapiens]
Length = 336
Score = 92.8 bits (229), Expect = 7e-19
Identities = 77/248 (31%), Positives = 116/248 (46%), Gaps = 34/248 (13%)
Query: 199 GRFGCVWKAQLMNDFVAVKIFPLQ-----DKQSWQSEREIFSTPGMKHENLLQFIAAEKR 253
G FG V+K + N VAVK ++ Q ++EI +HENL++ +
Sbjct: 71 GGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSD 130
Query: 254 GSNLEVELWLITAFHDKGSLTDYLK----GNIITWNELCHVAETMSRGLSYLHEDVPWCR 309
G +L L+ + GSL D L ++W+ C +A+ + G+++LHE+
Sbjct: 131 GD----DLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHEN----- 181
Query: 310 GEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEV 369
HRD KS N+LL TA ++DFGLA E T VGT YMAPE
Sbjct: 182 ------HHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEA 235
Query: 370 LEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVD-EYMLPFEEEIGQHPSLEELQ 428
L G I + D+Y+ G+VL E+++ A D + + +L +EEI E+
Sbjct: 236 LRGEIT------PKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDE---EKTI 286
Query: 429 EVVVHKKM 436
E + KKM
Sbjct: 287 EDYIDKKM 294
>gi|166795293 interleukin-1 receptor-associated kinase 4 isoform a
[Homo sapiens]
Length = 460
Score = 92.8 bits (229), Expect = 7e-19
Identities = 77/248 (31%), Positives = 116/248 (46%), Gaps = 34/248 (13%)
Query: 199 GRFGCVWKAQLMNDFVAVKIFPLQ-----DKQSWQSEREIFSTPGMKHENLLQFIAAEKR 253
G FG V+K + N VAVK ++ Q ++EI +HENL++ +
Sbjct: 195 GGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSD 254
Query: 254 GSNLEVELWLITAFHDKGSLTDYLK----GNIITWNELCHVAETMSRGLSYLHEDVPWCR 309
G +L L+ + GSL D L ++W+ C +A+ + G+++LHE+
Sbjct: 255 GD----DLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHEN----- 305
Query: 310 GEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEV 369
HRD KS N+LL TA ++DFGLA E T VGT YMAPE
Sbjct: 306 ------HHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEA 359
Query: 370 LEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVD-EYMLPFEEEIGQHPSLEELQ 428
L G I + D+Y+ G+VL E+++ A D + + +L +EEI E+
Sbjct: 360 LRGEIT------PKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDE---EKTI 410
Query: 429 EVVVHKKM 436
E + KKM
Sbjct: 411 EDYIDKKM 418
>gi|166795295 interleukin-1 receptor-associated kinase 4 isoform a
[Homo sapiens]
Length = 460
Score = 92.8 bits (229), Expect = 7e-19
Identities = 77/248 (31%), Positives = 116/248 (46%), Gaps = 34/248 (13%)
Query: 199 GRFGCVWKAQLMNDFVAVKIFPLQ-----DKQSWQSEREIFSTPGMKHENLLQFIAAEKR 253
G FG V+K + N VAVK ++ Q ++EI +HENL++ +
Sbjct: 195 GGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSD 254
Query: 254 GSNLEVELWLITAFHDKGSLTDYLK----GNIITWNELCHVAETMSRGLSYLHEDVPWCR 309
G +L L+ + GSL D L ++W+ C +A+ + G+++LHE+
Sbjct: 255 GD----DLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHEN----- 305
Query: 310 GEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEV 369
HRD KS N+LL TA ++DFGLA E T VGT YMAPE
Sbjct: 306 ------HHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEA 359
Query: 370 LEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVD-EYMLPFEEEIGQHPSLEELQ 428
L G I + D+Y+ G+VL E+++ A D + + +L +EEI E+
Sbjct: 360 LRGEIT------PKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDE---EKTI 410
Query: 429 EVVVHKKM 436
E + KKM
Sbjct: 411 EDYIDKKM 418
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 85.1 bits (209), Expect = 1e-16
Identities = 88/306 (28%), Positives = 139/306 (45%), Gaps = 59/306 (19%)
Query: 190 LQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIA 249
LQ E G FG V++A+ ++ V + L + E EI S + H N++QF
Sbjct: 16 LQFFENCGGGSFGSVYRAKWISQDKEVAVKKLL---KIEKEAEILSV--LSHRNIIQFYG 70
Query: 250 AEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHV---AETMSRGLSYLHEDVP 306
N + +T + GSL DY+ N ++ H+ A +++G+ YLH + P
Sbjct: 71 VILEPPNYGI----VTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAP 126
Query: 307 WCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTH-GQVGTRRYM 365
+ HRD KS+NV++ +D + DFG A RF TH VGT +M
Sbjct: 127 --------VKVIHRDLKSRNVVIAADGVLKICDFG-ASRFH----NHTTHMSLVGTFPWM 173
Query: 366 APEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLE 425
APEV++ D Y+ G+VLWE+++R +PF+ LE
Sbjct: 174 APEVIQSL-----PVSETCDTYSYGVVLWEMLTR-----------EVPFK-------GLE 210
Query: 426 ELQE--VVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRR 483
LQ +VV K R TI + A+L + +CW+ DA+ R S ++ +S++
Sbjct: 211 GLQVAWLVVEKNERLTIPSSCPR--SFAEL---LHQCWEADAKKRPS---FKQIISILES 262
Query: 484 SVNGTT 489
N T+
Sbjct: 263 MSNDTS 268
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 85.1 bits (209), Expect = 1e-16
Identities = 88/306 (28%), Positives = 139/306 (45%), Gaps = 59/306 (19%)
Query: 190 LQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIA 249
LQ E G FG V++A+ ++ V + L + E EI S + H N++QF
Sbjct: 16 LQFFENCGGGSFGSVYRAKWISQDKEVAVKKLL---KIEKEAEILSV--LSHRNIIQFYG 70
Query: 250 AEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHV---AETMSRGLSYLHEDVP 306
N + +T + GSL DY+ N ++ H+ A +++G+ YLH + P
Sbjct: 71 VILEPPNYGI----VTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAP 126
Query: 307 WCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTH-GQVGTRRYM 365
+ HRD KS+NV++ +D + DFG A RF TH VGT +M
Sbjct: 127 --------VKVIHRDLKSRNVVIAADGVLKICDFG-ASRFH----NHTTHMSLVGTFPWM 173
Query: 366 APEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLE 425
APEV++ D Y+ G+VLWE+++R +PF+ LE
Sbjct: 174 APEVIQSL-----PVSETCDTYSYGVVLWEMLTR-----------EVPFK-------GLE 210
Query: 426 ELQE--VVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRR 483
LQ +VV K R TI + A+L + +CW+ DA+ R S ++ +S++
Sbjct: 211 GLQVAWLVVEKNERLTIPSSCPR--SFAEL---LHQCWEADAKKRPS---FKQIISILES 262
Query: 484 SVNGTT 489
N T+
Sbjct: 263 MSNDTS 268
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 80.5 bits (197), Expect = 3e-15
Identities = 57/214 (26%), Positives = 106/214 (49%), Gaps = 21/214 (9%)
Query: 191 QLLEIKARGRFGCVWKAQLMN--DFVAVKIFPLQDKQSWQSEREIFSTPGMKHE-NLLQF 247
+L+E+ G +G V+K + + A+K+ + + + ++EI H N+ +
Sbjct: 26 ELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATY 85
Query: 248 IAA--EKRGSNLEVELWLITAFHDKGSLTDYLK---GNIITWNELCHVAETMSRGLSYLH 302
A +K ++ +LWL+ F GS+TD +K GN + + ++ + RGLS+LH
Sbjct: 86 YGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLH 145
Query: 303 EDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTR 362
+ HK + HRD K +NVLL + L DFG++ + + + G + +GT
Sbjct: 146 Q---------HK--VIHRDIKGQNVLLTENAEVKLVDFGVSAQLD--RTVGRRNTFIGTP 192
Query: 363 RYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWEL 396
+MAPEV+ N + D++++G+ E+
Sbjct: 193 YWMAPEVIACDENPDATYDFKSDLWSLGITAIEM 226
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.443
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,848,096
Number of Sequences: 37866
Number of extensions: 1196916
Number of successful extensions: 5377
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 368
Number of HSP's successfully gapped in prelim test: 342
Number of HSP's that attempted gapping in prelim test: 4270
Number of HSP's gapped (non-prelim): 861
length of query: 512
length of database: 18,247,518
effective HSP length: 107
effective length of query: 405
effective length of database: 14,195,856
effective search space: 5749321680
effective search space used: 5749321680
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.