Guide to the Human Genome
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Search of human proteins with 239743634

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239743634 PREDICTED: hypothetical protein XP_002342919 [Homo
sapiens]
         (692 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239749498 PREDICTED: hypothetical protein [Homo sapiens]          1406   0.0  
gi|239743634 PREDICTED: hypothetical protein XP_002342919 [Homo ...  1406   0.0  
gi|24586659 scavenger receptor class F, member 2 isoform 1 [Homo...    50   9e-06
gi|33598937 scavenger receptor class F, member 2 isoform 2 [Homo...    50   9e-06
gi|239753839 PREDICTED: hypothetical protein [Homo sapiens]            49   2e-05
gi|239742467 PREDICTED: double homeobox, 4-like [Homo sapiens]         48   3e-05
gi|33286446 opioid growth factor receptor [Homo sapiens]               47   5e-05
gi|239749695 PREDICTED: hypothetical protein XP_002347121 [Homo ...    46   1e-04
gi|239743961 PREDICTED: hypothetical protein XP_002344246 [Homo ...    46   1e-04
gi|110832843 TBP-associated factor 4 [Homo sapiens]                    45   2e-04
gi|239744249 PREDICTED: similar to double homeobox, 4 [Homo sapi...    45   2e-04
gi|239744248 PREDICTED: similar to double homeobox, 4 [Homo sapi...    45   2e-04
gi|239744246 PREDICTED: hypothetical protein XP_002343082 [Homo ...    45   2e-04
gi|239744244 PREDICTED: similar to double homeobox, 4 [Homo sapi...    45   2e-04
gi|239744242 PREDICTED: similar to double homeobox, 4 [Homo sapi...    45   2e-04
gi|239744240 PREDICTED: similar to double homeobox, 4 [Homo sapi...    45   2e-04
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f...    45   2e-04
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    45   2e-04
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    45   2e-04
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ...    45   2e-04
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...    45   2e-04
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ...    45   2e-04
gi|157785645 SPEG complex locus [Homo sapiens]                         45   2e-04
gi|153945765 mitogen-activated protein kinase kinase kinase 1 [H...    45   3e-04
gi|239742468 PREDICTED: double homeobox, 4-like [Homo sapiens]         45   3e-04
gi|194272172 double homeobox, 4 [Homo sapiens]                         45   3e-04
gi|194272217 double homeobox, 4-like [Homo sapiens]                    45   3e-04
gi|194272216 double homeobox, 4-like [Homo sapiens]                    45   3e-04
gi|194272215 double homeobox, 4-like [Homo sapiens]                    45   3e-04
gi|194272192 double homeobox, 4-like [Homo sapiens]                    45   3e-04

>gi|239749498 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 692

 Score = 1406 bits (3639), Expect = 0.0
 Identities = 692/692 (100%), Positives = 692/692 (100%)

Query: 1   MDEFELLIFAKSDTASYQRPDTLTTMGLFKSRSPREEGARTNCHHTEGGAGDKGKSCLPT 60
           MDEFELLIFAKSDTASYQRPDTLTTMGLFKSRSPREEGARTNCHHTEGGAGDKGKSCLPT
Sbjct: 1   MDEFELLIFAKSDTASYQRPDTLTTMGLFKSRSPREEGARTNCHHTEGGAGDKGKSCLPT 60

Query: 61  DSRFPANLLHQKCCHKKTVWTQFPDDIPITGPNFFRVTSQVCSHSLVPSLYRPYEKYLAW 120
           DSRFPANLLHQKCCHKKTVWTQFPDDIPITGPNFFRVTSQVCSHSLVPSLYRPYEKYLAW
Sbjct: 61  DSRFPANLLHQKCCHKKTVWTQFPDDIPITGPNFFRVTSQVCSHSLVPSLYRPYEKYLAW 120

Query: 121 QLPALLDGVEVVGGKLGAEGVLRCHRAAAIVLRAVAGAGAHRLQVRDVRLVPGPAGPRLL 180
           QLPALLDGVEVVGGKLGAEGVLRCHRAAAIVLRAVAGAGAHRLQVRDVRLVPGPAGPRLL
Sbjct: 121 QLPALLDGVEVVGGKLGAEGVLRCHRAAAIVLRAVAGAGAHRLQVRDVRLVPGPAGPRLL 180

Query: 181 RDVNDHAVAVSGEGCPLFSIPPLILTVHGQEPEDDQVEEGPDDRQPHQDIHKAKGHVERL 240
           RDVNDHAVAVSGEGCPLFSIPPLILTVHGQEPEDDQVEEGPDDRQPHQDIHKAKGHVERL
Sbjct: 181 RDVNDHAVAVSGEGCPLFSIPPLILTVHGQEPEDDQVEEGPDDRQPHQDIHKAKGHVERL 240

Query: 241 LLQGTLGLQGHVVPEPNGSQRDEAVVVGVEEAPLLTLGEGGRPDAQRPHAGEEAHSHHVL 300
           LLQGTLGLQGHVVPEPNGSQRDEAVVVGVEEAPLLTLGEGGRPDAQRPHAGEEAHSHHVL
Sbjct: 241 LLQGTLGLQGHVVPEPNGSQRDEAVVVGVEEAPLLTLGEGGRPDAQRPHAGEEAHSHHVL 300

Query: 301 HRHVSVAHATALLNALQQVAHEGVHALAQALEHDQCQRDAQHGVEHAEGLARIGARCSVP 360
           HRHVSVAHATALLNALQQVAHEGVHALAQALEHDQCQRDAQHGVEHAEGLARIGARCSVP
Sbjct: 301 HRHVSVAHATALLNALQQVAHEGVHALAQALEHDQCQRDAQHGVEHAEGLARIGARCSVP 360

Query: 361 ITSLTYGGDDRDRKVEGAGEFPLDAGAVRFRLQDHQLQLPVVLAADVVLPLDPDLLGFEF 420
           ITSLTYGGDDRDRKVEGAGEFPLDAGAVRFRLQDHQLQLPVVLAADVVLPLDPDLLGFEF
Sbjct: 361 ITSLTYGGDDRDRKVEGAGEFPLDAGAVRFRLQDHQLQLPVVLAADVVLPLDPDLLGFEF 420

Query: 421 LLLAHLVVRLEGVEHGGAHQQVGEGADDEGQSPHVLPLHGRQQGAGAGGMSRRLTAARVP 480
           LLLAHLVVRLEGVEHGGAHQQVGEGADDEGQSPHVLPLHGRQQGAGAGGMSRRLTAARVP
Sbjct: 421 LLLAHLVVRLEGVEHGGAHQQVGEGADDEGQSPHVLPLHGRQQGAGAGGMSRRLTAARVP 480

Query: 481 LQRPAAAAASSSAAAAAASKLGGAGPGSAEKADRHRRLLERRGQASGNPDTLRQTRPKQP 540
           LQRPAAAAASSSAAAAAASKLGGAGPGSAEKADRHRRLLERRGQASGNPDTLRQTRPKQP
Sbjct: 481 LQRPAAAAASSSAAAAAASKLGGAGPGSAEKADRHRRLLERRGQASGNPDTLRQTRPKQP 540

Query: 541 APLRRAMQGGPAGYRAGLAALRTPPPAPAGNAGTGTGARKRPEGGRGARYPCGSSSRVAV 600
           APLRRAMQGGPAGYRAGLAALRTPPPAPAGNAGTGTGARKRPEGGRGARYPCGSSSRVAV
Sbjct: 541 APLRRAMQGGPAGYRAGLAALRTPPPAPAGNAGTGTGARKRPEGGRGARYPCGSSSRVAV 600

Query: 601 PSKEPAGPRAQRNLLPLLPLLAPSRWWGGKVCEVAVSLESPASGEGAEQVQREGQPAPQS 660
           PSKEPAGPRAQRNLLPLLPLLAPSRWWGGKVCEVAVSLESPASGEGAEQVQREGQPAPQS
Sbjct: 601 PSKEPAGPRAQRNLLPLLPLLAPSRWWGGKVCEVAVSLESPASGEGAEQVQREGQPAPQS 660

Query: 661 PAPQERKQPWRVESLRDSGLEEENGIQPEMAG 692
           PAPQERKQPWRVESLRDSGLEEENGIQPEMAG
Sbjct: 661 PAPQERKQPWRVESLRDSGLEEENGIQPEMAG 692


>gi|239743634 PREDICTED: hypothetical protein XP_002342919 [Homo
           sapiens]
          Length = 692

 Score = 1406 bits (3639), Expect = 0.0
 Identities = 692/692 (100%), Positives = 692/692 (100%)

Query: 1   MDEFELLIFAKSDTASYQRPDTLTTMGLFKSRSPREEGARTNCHHTEGGAGDKGKSCLPT 60
           MDEFELLIFAKSDTASYQRPDTLTTMGLFKSRSPREEGARTNCHHTEGGAGDKGKSCLPT
Sbjct: 1   MDEFELLIFAKSDTASYQRPDTLTTMGLFKSRSPREEGARTNCHHTEGGAGDKGKSCLPT 60

Query: 61  DSRFPANLLHQKCCHKKTVWTQFPDDIPITGPNFFRVTSQVCSHSLVPSLYRPYEKYLAW 120
           DSRFPANLLHQKCCHKKTVWTQFPDDIPITGPNFFRVTSQVCSHSLVPSLYRPYEKYLAW
Sbjct: 61  DSRFPANLLHQKCCHKKTVWTQFPDDIPITGPNFFRVTSQVCSHSLVPSLYRPYEKYLAW 120

Query: 121 QLPALLDGVEVVGGKLGAEGVLRCHRAAAIVLRAVAGAGAHRLQVRDVRLVPGPAGPRLL 180
           QLPALLDGVEVVGGKLGAEGVLRCHRAAAIVLRAVAGAGAHRLQVRDVRLVPGPAGPRLL
Sbjct: 121 QLPALLDGVEVVGGKLGAEGVLRCHRAAAIVLRAVAGAGAHRLQVRDVRLVPGPAGPRLL 180

Query: 181 RDVNDHAVAVSGEGCPLFSIPPLILTVHGQEPEDDQVEEGPDDRQPHQDIHKAKGHVERL 240
           RDVNDHAVAVSGEGCPLFSIPPLILTVHGQEPEDDQVEEGPDDRQPHQDIHKAKGHVERL
Sbjct: 181 RDVNDHAVAVSGEGCPLFSIPPLILTVHGQEPEDDQVEEGPDDRQPHQDIHKAKGHVERL 240

Query: 241 LLQGTLGLQGHVVPEPNGSQRDEAVVVGVEEAPLLTLGEGGRPDAQRPHAGEEAHSHHVL 300
           LLQGTLGLQGHVVPEPNGSQRDEAVVVGVEEAPLLTLGEGGRPDAQRPHAGEEAHSHHVL
Sbjct: 241 LLQGTLGLQGHVVPEPNGSQRDEAVVVGVEEAPLLTLGEGGRPDAQRPHAGEEAHSHHVL 300

Query: 301 HRHVSVAHATALLNALQQVAHEGVHALAQALEHDQCQRDAQHGVEHAEGLARIGARCSVP 360
           HRHVSVAHATALLNALQQVAHEGVHALAQALEHDQCQRDAQHGVEHAEGLARIGARCSVP
Sbjct: 301 HRHVSVAHATALLNALQQVAHEGVHALAQALEHDQCQRDAQHGVEHAEGLARIGARCSVP 360

Query: 361 ITSLTYGGDDRDRKVEGAGEFPLDAGAVRFRLQDHQLQLPVVLAADVVLPLDPDLLGFEF 420
           ITSLTYGGDDRDRKVEGAGEFPLDAGAVRFRLQDHQLQLPVVLAADVVLPLDPDLLGFEF
Sbjct: 361 ITSLTYGGDDRDRKVEGAGEFPLDAGAVRFRLQDHQLQLPVVLAADVVLPLDPDLLGFEF 420

Query: 421 LLLAHLVVRLEGVEHGGAHQQVGEGADDEGQSPHVLPLHGRQQGAGAGGMSRRLTAARVP 480
           LLLAHLVVRLEGVEHGGAHQQVGEGADDEGQSPHVLPLHGRQQGAGAGGMSRRLTAARVP
Sbjct: 421 LLLAHLVVRLEGVEHGGAHQQVGEGADDEGQSPHVLPLHGRQQGAGAGGMSRRLTAARVP 480

Query: 481 LQRPAAAAASSSAAAAAASKLGGAGPGSAEKADRHRRLLERRGQASGNPDTLRQTRPKQP 540
           LQRPAAAAASSSAAAAAASKLGGAGPGSAEKADRHRRLLERRGQASGNPDTLRQTRPKQP
Sbjct: 481 LQRPAAAAASSSAAAAAASKLGGAGPGSAEKADRHRRLLERRGQASGNPDTLRQTRPKQP 540

Query: 541 APLRRAMQGGPAGYRAGLAALRTPPPAPAGNAGTGTGARKRPEGGRGARYPCGSSSRVAV 600
           APLRRAMQGGPAGYRAGLAALRTPPPAPAGNAGTGTGARKRPEGGRGARYPCGSSSRVAV
Sbjct: 541 APLRRAMQGGPAGYRAGLAALRTPPPAPAGNAGTGTGARKRPEGGRGARYPCGSSSRVAV 600

Query: 601 PSKEPAGPRAQRNLLPLLPLLAPSRWWGGKVCEVAVSLESPASGEGAEQVQREGQPAPQS 660
           PSKEPAGPRAQRNLLPLLPLLAPSRWWGGKVCEVAVSLESPASGEGAEQVQREGQPAPQS
Sbjct: 601 PSKEPAGPRAQRNLLPLLPLLAPSRWWGGKVCEVAVSLESPASGEGAEQVQREGQPAPQS 660

Query: 661 PAPQERKQPWRVESLRDSGLEEENGIQPEMAG 692
           PAPQERKQPWRVESLRDSGLEEENGIQPEMAG
Sbjct: 661 PAPQERKQPWRVESLRDSGLEEENGIQPEMAG 692


>gi|24586659 scavenger receptor class F, member 2 isoform 1 [Homo
           sapiens]
          Length = 870

 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 62/216 (28%), Positives = 81/216 (37%), Gaps = 30/216 (13%)

Query: 479 VPLQRPAAAA------ASSSAAAAAASKLGGAGPGSAEKADRHRRLLERRGQASG---NP 529
           VPL  PA+A       ASS +  +A+S  G  G   A  A R  R    RG+  G   +P
Sbjct: 593 VPLTTPASAEEAIPLPASSDSERSASSVEGPGGALYARVARREARPARARGEIGGLSLSP 652

Query: 530 DTLRQTRPKQPAPLRRAMQGGPAGYRAGLAALRTP-PPAPAGNAGTGTGARKRPEGGRGA 588
              R+ +P  P P  +       G  +  AA R P PP P   A      RKR    + A
Sbjct: 653 SPERR-KPPPPDPATKPKVSWIHGKHSAAAAGRAPSPPPPGSEAAPSPSKRKRTPSDKSA 711

Query: 589 RYPCGSSSRVAVPSKEPAG-------------PRAQRNLLPLLPLLAPSRWWG-GKVCEV 634
                 S R   P+  P G             PRA+    P  PL A  R     K  E 
Sbjct: 712 HTVEHGSPRTRDPTPRPPGLPEEATALAAPSPPRARARAAP-RPLGAHGRRRSPAKRAEA 770

Query: 635 AVSLESPASGE----GAEQVQREGQPAPQSPAPQER 666
           A  L +   G+    G  +V    Q   + PAP ++
Sbjct: 771 ASMLAADVRGKTRSLGRAEVALGAQGPREKPAPPQK 806


>gi|33598937 scavenger receptor class F, member 2 isoform 2 [Homo
           sapiens]
          Length = 865

 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 62/216 (28%), Positives = 81/216 (37%), Gaps = 30/216 (13%)

Query: 479 VPLQRPAAAA------ASSSAAAAAASKLGGAGPGSAEKADRHRRLLERRGQASG---NP 529
           VPL  PA+A       ASS +  +A+S  G  G   A  A R  R    RG+  G   +P
Sbjct: 588 VPLTTPASAEEAIPLPASSDSERSASSVEGPGGALYARVARREARPARARGEIGGLSLSP 647

Query: 530 DTLRQTRPKQPAPLRRAMQGGPAGYRAGLAALRTP-PPAPAGNAGTGTGARKRPEGGRGA 588
              R+ +P  P P  +       G  +  AA R P PP P   A      RKR    + A
Sbjct: 648 SPERR-KPPPPDPATKPKVSWIHGKHSAAAAGRAPSPPPPGSEAAPSPSKRKRTPSDKSA 706

Query: 589 RYPCGSSSRVAVPSKEPAG-------------PRAQRNLLPLLPLLAPSRWWG-GKVCEV 634
                 S R   P+  P G             PRA+    P  PL A  R     K  E 
Sbjct: 707 HTVEHGSPRTRDPTPRPPGLPEEATALAAPSPPRARARAAP-RPLGAHGRRRSPAKRAEA 765

Query: 635 AVSLESPASGE----GAEQVQREGQPAPQSPAPQER 666
           A  L +   G+    G  +V    Q   + PAP ++
Sbjct: 766 ASMLAADVRGKTRSLGRAEVALGAQGPREKPAPPQK 801


>gi|239753839 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 257

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 52/156 (33%), Positives = 63/156 (40%), Gaps = 27/156 (17%)

Query: 460 GRQQGAGAGGMSRRLTAARVPLQRPAAAAA---SSSAAAAAASKLGGAGPGSAEKADRHR 516
           G Q+  GAGG          PL  PA +AA    + A+ AA  + G AGP       R R
Sbjct: 64  GSQEHPGAGG----------PLCFPARSAAWGPPARASRAAGRRAGPAGP-PCRAPGRGR 112

Query: 517 RLLERRGQASGNPDTLRQTRPKQPAPLRRAMQGGPAGYRAG---LAALRTPPPAPAGNAG 573
               RR  A G       T    PA + RA  G  A   AG   + A R PPP    + G
Sbjct: 113 AAATRRSPAPG-------TARGSPAGVERA-GGATAASSAGTRSVPARRLPPPCGGTSLG 164

Query: 574 TGTGARKRPEGGRGARYPCGSSSRVAVPSKEPAGPR 609
            G+ A +RP      R P  S    A+P   P  PR
Sbjct: 165 AGSRALRRPGSAALPRSPSSSRRWAAMPG--PGAPR 198



 Score = 30.4 bits (67), Expect = 5.7
 Identities = 37/132 (28%), Positives = 47/132 (35%), Gaps = 29/132 (21%)

Query: 542 PLRRAMQGGPA------GYRAGLAALRTPPPAPAGNAGTGTGARKRPEGGRGARYPCGSS 595
           P R A  G PA      G RAG A     PP  A   G     R+ P  G     P G  
Sbjct: 78  PARSAAWGPPARASRAAGRRAGPAG----PPCRAPGRGRAAATRRSPAPGTARGSPAGVE 133

Query: 596 SRVAVPSKEPAGPRAQRNLLPLLPLLAPSRWWGGKVCEVAVSLESPASGEGAEQVQREGQ 655
                 +   AG R+    +P   L  P    GG            + G G+  ++R G 
Sbjct: 134 RAGGATAASSAGTRS----VPARRLPPPC---GG-----------TSLGAGSRALRRPGS 175

Query: 656 PA-PQSPAPQER 666
            A P+SP+   R
Sbjct: 176 AALPRSPSSSRR 187


>gi|239742467 PREDICTED: double homeobox, 4-like [Homo sapiens]
          Length = 483

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 49/150 (32%), Positives = 56/150 (37%), Gaps = 28/150 (18%)

Query: 536 RPKQPAPLRRAMQGGPAGYRAGLAALRTP------PPAPAGNAGTGTGARKRPEGGRGAR 589
           +P Q AP     Q  PA      AA   P      P AP      G     R     G  
Sbjct: 280 QPSQAAPAEGVSQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLP 339

Query: 590 YPCGSSSRVAVPSKEPAGPRAQRNLLPLLPLLAPSRWWG-GKVCEVAVSLESPASGE--- 645
            PC     VA P    AGP+ Q  L P  P    S WWG G+  +VA +   P +GE   
Sbjct: 340 GPCA----VAQPGPAQAGPQGQGVLAP--PTSQGSPWWGWGRGPQVAGAAWEPQAGEAPP 393

Query: 646 --------GAEQVQREGQPAP----QSPAP 663
                    A Q Q +G PAP    Q PAP
Sbjct: 394 PQPAPPDASARQGQMQGIPAPSQALQEPAP 423


>gi|33286446 opioid growth factor receptor [Homo sapiens]
          Length = 677

 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 51/187 (27%), Positives = 61/187 (32%), Gaps = 29/187 (15%)

Query: 487 AAASSSAAAAAASKLGGAGPGSAEKADRHRRLLE-----RRGQASGNPDTLRQTRPKQPA 541
           +AA +S  A   +  G   P    KA      +E     R G   G P +  +T    PA
Sbjct: 468 SAAVASGGAQTLALAGSPAPSGHPKAGHSENGVEEDTEGRTGPKEGTPGSPSETPGPSPA 527

Query: 542 PLRRAMQGGPAGYRAGLAALRTPPPAPAGNAGTGTGARKRPEGGRGARYPCG---SSSRV 598
                   GPAG     +   TP P PAG AG           G     P G   + S  
Sbjct: 528 --------GPAGDEPAESPSETPGPRPAGPAGDEPAESPSETPGPRPAGPAGDEPAESPS 579

Query: 599 AVPSKEPAGPRAQRNLLPLLPLLAPSRWWGGKVCEVAVSLESPASGEGAEQVQREGQPAP 658
             P   PAGP          P  +PS   G +          PA  E AE       P P
Sbjct: 580 ETPGPSPAGPTRDE------PAESPSETPGPRPA-------GPAGDEPAESPSETPGPRP 626

Query: 659 QSPAPQE 665
             PA  E
Sbjct: 627 AGPAGDE 633



 Score = 34.3 bits (77), Expect = 0.40
 Identities = 33/130 (25%), Positives = 47/130 (36%), Gaps = 11/130 (8%)

Query: 443 GEGADDEGQSPHVLPLHGRQQGAGAGGMSRRLTAARVPLQRPAAAAASSSAAAAAASKLG 502
           G   D+  +SP   P     + AG  G     + +  P  RPA  A    A +   S+  
Sbjct: 528 GPAGDEPAESPSETP---GPRPAGPAGDEPAESPSETPGPRPAGPAGDEPAESP--SETP 582

Query: 503 GAGPGSAEKADRHRRLLERRGQASGNP--DTLRQTRPKQPAPLRRAMQGGPAGYRAGLAA 560
           G  P    + +      E  G     P  D   ++  + P P       GPAG     + 
Sbjct: 583 GPSPAGPTRDEPAESPSETPGPRPAGPAGDEPAESPSETPGP----RPAGPAGDEPAESP 638

Query: 561 LRTPPPAPAG 570
             TP P+PAG
Sbjct: 639 SETPGPSPAG 648


>gi|239749695 PREDICTED: hypothetical protein XP_002347121 [Homo
           sapiens]
          Length = 594

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 67/225 (29%), Positives = 80/225 (35%), Gaps = 57/225 (25%)

Query: 462 QQGAGAGGMSRRLTA-ARVPLQRPAAAAASSSAAAA--------AASKLGG------AGP 506
           Q GA  G     +T   R  L R   A A    AAA        A +KLGG       GP
Sbjct: 359 QAGARVGEAREAVTTHERAHLDREGEARARLGQAAAQMRREGWGARAKLGGRGVCGKCGP 418

Query: 507 GSAEKADRHRRLLERRGQASGNPDTLRQTRPKQPAPLRRAMQGGPAGYRAGLAALRTPPP 566
           G  +   R R           NP                A +   AG RAG A  RT   
Sbjct: 419 GPWDDPARRR-----------NPGA--------------AARAKLAGQRAGRARARTGSQ 453

Query: 567 APAGNAGTGTGARKRPEGGRGARYPCGSSSRVAVPSKEPAGPRAQRNLLPLLPLLAPSRW 626
             +   G G GA + P GGR      G+  R      E A PR  R LLP LP + P+R 
Sbjct: 454 VGSRGRGWGPGAGRVPSGGRRG---VGNPERW---GGEAAAPRPSRVLLPELPAVDPAR- 506

Query: 627 WGGKVCEVAVSLESPASGEGAEQVQR--EGQPAPQSPAPQERKQP 669
                       E  A+ +  E   R  +G  AP S  P  R +P
Sbjct: 507 --------DTRREPDAAAQRTELGGRVGKGPGAPPSALPGPRPRP 543


>gi|239743961 PREDICTED: hypothetical protein XP_002344246 [Homo
           sapiens]
          Length = 594

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 67/225 (29%), Positives = 80/225 (35%), Gaps = 57/225 (25%)

Query: 462 QQGAGAGGMSRRLTA-ARVPLQRPAAAAASSSAAAA--------AASKLGG------AGP 506
           Q GA  G     +T   R  L R   A A    AAA        A +KLGG       GP
Sbjct: 359 QAGARVGEAREAVTTHERAHLDREGEARARLGQAAAQMRREGWGARAKLGGRGVCGKCGP 418

Query: 507 GSAEKADRHRRLLERRGQASGNPDTLRQTRPKQPAPLRRAMQGGPAGYRAGLAALRTPPP 566
           G  +   R R           NP                A +   AG RAG A  RT   
Sbjct: 419 GPWDDPARRR-----------NPGA--------------AARAKLAGQRAGRARARTGSQ 453

Query: 567 APAGNAGTGTGARKRPEGGRGARYPCGSSSRVAVPSKEPAGPRAQRNLLPLLPLLAPSRW 626
             +   G G GA + P GGR      G+  R      E A PR  R LLP LP + P+R 
Sbjct: 454 VGSRGRGWGPGAGRVPSGGRRG---VGNPERW---GGEAAAPRPSRVLLPELPAVDPAR- 506

Query: 627 WGGKVCEVAVSLESPASGEGAEQVQR--EGQPAPQSPAPQERKQP 669
                       E  A+ +  E   R  +G  AP S  P  R +P
Sbjct: 507 --------DTRREPDAAAQRTELGGRVGKGPGAPPSALPGPRPRP 543


>gi|110832843 TBP-associated factor 4 [Homo sapiens]
          Length = 1085

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 44/134 (32%), Positives = 53/134 (39%), Gaps = 21/134 (15%)

Query: 476 AARVPLQRPAAAAASSSAAAAAASKLGGAGPGSAEKADRHRRLLERRGQASGNPDTLRQT 535
           A R P  R AAA A  +   +  S  G AG G A  A+         G     P+     
Sbjct: 44  APRTPEVRAAAAGALGNHVVSG-SPAGAAGAGPAAPAE---------GAPGAAPE----- 88

Query: 536 RPKQPAPLRRAMQGGPAGYRAGLAALRTPPPAPAGNAGTGTGARKRPEGGRGARYPCGSS 595
               P P  RA  GG    R G  + R P   PAG A      R  PEG  G+  P  ++
Sbjct: 89  ----PPPAGRARPGGGGPQRPGPPSPRRPL-VPAGPAPPAAKLRPPPEGSAGSCAPVPAA 143

Query: 596 SRVAV-PSKEPAGP 608
           + VA  P   PAGP
Sbjct: 144 AAVAAGPEPAPAGP 157



 Score = 38.1 bits (87), Expect = 0.028
 Identities = 64/241 (26%), Positives = 85/241 (35%), Gaps = 44/241 (18%)

Query: 454 HVLPLHGRQQGAGAGGMSRRLTA---ARVPLQRPAAAAASSSAAA-----AAASKLGGAG 505
           H+ P     + A AG +   + +   A      PAA A  +  AA     A  ++ GG G
Sbjct: 42  HLAPRTPEVRAAAAGALGNHVVSGSPAGAAGAGPAAPAEGAPGAAPEPPPAGRARPGGGG 101

Query: 506 P---------------GSAEKADRHRRLLE-RRGQASGNPDTLRQTRPKQPAPLRRAMQG 549
           P               G A  A + R   E   G  +  P         +PAP   A   
Sbjct: 102 PQRPGPPSPRRPLVPAGPAPPAAKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPA 161

Query: 550 GPAGYRAGLAALRTPPPAPAGNAGTGTGARKRPEGGRGARYPCGSSSRV-AVPSKEPAGP 608
           GP    A LAA   P P P    G G G  K P G   A+   GS++ + +  +  PA  
Sbjct: 162 GP----AALAARAGPGPGPGPGPGPGPGPGK-PAGPGAAQTLNGSAALLNSHHAAAPAVS 216

Query: 609 RAQRNLLPLLPLLAPSRWWGGKVCEVAVSLESPASGEGAEQVQREGQPAPQSPAPQERKQ 668
                   LLPL  P+    G V +       P  G  A        PAP +P+P     
Sbjct: 217 LVNNGPAALLPLPKPAA--PGTVIQT-----PPFVGAAA-------PPAPAAPSPPAAPA 262

Query: 669 P 669
           P
Sbjct: 263 P 263



 Score = 37.4 bits (85), Expect = 0.047
 Identities = 51/186 (27%), Positives = 66/186 (35%), Gaps = 41/186 (22%)

Query: 443 GEGADDEGQSPHVLPLHGRQQGAGAGGMSRRLTAARVPLQRPAAAAASSSAAAAAASKLG 502
           G  A     +P V P    Q G  AG                 AA A + AA   A   G
Sbjct: 285 GHPAGPPTAAPAVPPPAAAQNGGSAG-----------------AAPAPAPAAGGPAGVSG 327

Query: 503 GAGPGSAE-------KADRHRRLLERRGQASGNPDTLRQTRPKQPAPLRRAMQGGPAGYR 555
             GPG+A        KA+  +R+++        P   +      PA    +M  GP    
Sbjct: 328 QPGPGAAAAAPAPGVKAESPKRVVQAA------PPAAQTLAASGPASTAASMVIGPTMQG 381

Query: 556 AGLAALRTPPPAPAGNAGTGTGARKRPEGGRGARYPCGSSSRVAVPSKEPAGPRAQRNLL 615
           A  +    PPPAP    GT TG    P+G  GA     + S    P+   +G RA     
Sbjct: 382 ALPSPAAVPPPAP----GTPTGL---PKGAAGA----VTQSLSRTPTATTSGIRATLTPT 430

Query: 616 PLLPLL 621
            L P L
Sbjct: 431 VLAPRL 436



 Score = 30.8 bits (68), Expect = 4.4
 Identities = 39/131 (29%), Positives = 44/131 (33%), Gaps = 19/131 (14%)

Query: 484 PAAAAASSSAAAAAASKLGGAGPGSAEKADRHRRLLERRGQASGNPDTLRQTRPKQPAPL 543
           PA AA S  AA A A+      P     A     L    G  +G P       P  P P 
Sbjct: 250 PAPAAPSPPAAPAPAAPAAAPPPPPPAPAT----LARPPGHPAGPPTAA----PAVPPPA 301

Query: 544 RRAMQGGPAGYRAGLAALRTPPPAPAGNAGTGTGARKRPEGGRGARYPCGSSSRVAVPSK 603
             A  GG AG          P PAPA  AG   G   +P  G  A  P       +    
Sbjct: 302 A-AQNGGSAG--------AAPAPAPA--AGGPAGVSGQPGPGAAAAAPAPGVKAESPKRV 350

Query: 604 EPAGPRAQRNL 614
             A P A + L
Sbjct: 351 VQAAPPAAQTL 361



 Score = 30.4 bits (67), Expect = 5.7
 Identities = 53/185 (28%), Positives = 65/185 (35%), Gaps = 31/185 (16%)

Query: 485 AAAAASSSAAAAAASKLGGAGPGSAEKADRHRRLLERRGQASGNPDTLRQTRP--KQPAP 542
           +AA  +S  AAA A  L   GP +         LL     A+  P T+ QT P     AP
Sbjct: 201 SAALLNSHHAAAPAVSLVNNGPAA---------LLPLPKPAA--PGTVIQTPPFVGAAAP 249

Query: 543 LRRAMQGGPAGYRAGLAALRTPPPAPAGNAGTGTGARKRPEGGRGARYPCGSSSRVAVPS 602
              A    PA       A   PPP PA           RP G     +P G  +  A P+
Sbjct: 250 PAPAAPSPPAAPAPAAPAAAPPPPPPA------PATLARPPG-----HPAGPPT--AAPA 296

Query: 603 KEPAGPRAQRNLLPLLPLLAPSRWWGGKVC---EVAVSLESPASGEGAEQVQREGQPAPQ 659
             P             P  AP+      V        +  +PA G  AE  +R  Q AP 
Sbjct: 297 VPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGVKAESPKRVVQAAP- 355

Query: 660 SPAPQ 664
            PA Q
Sbjct: 356 -PAAQ 359


>gi|239744249 PREDICTED: similar to double homeobox, 4 [Homo
           sapiens]
          Length = 483

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 48/150 (32%), Positives = 55/150 (36%), Gaps = 28/150 (18%)

Query: 536 RPKQPAPLRRAMQGGPAGYRAGLAALRTP------PPAPAGNAGTGTGARKRPEGGRGAR 589
           +P Q AP     Q  PA      AA   P      P AP      G     R     G  
Sbjct: 280 QPSQAAPAEGISQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLP 339

Query: 590 YPCGSSSRVAVPSKEPAGPRAQRNLLPLLPLLAPSRWWG-GKVCEVAVSLESPASG---- 644
            PC     VA P    AGP+ Q  L P  P    S WWG G+  +VA +   P +G    
Sbjct: 340 GPCA----VAQPGPAQAGPQGQGVLAP--PTSQGSPWWGWGRGPQVAGAAWEPQAGAAPP 393

Query: 645 -------EGAEQVQREGQPAP----QSPAP 663
                    A Q Q +G PAP    Q PAP
Sbjct: 394 PQPAPPDASARQGQMQGIPAPSQALQEPAP 423


>gi|239744248 PREDICTED: similar to double homeobox, 4 [Homo
           sapiens]
          Length = 483

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 48/150 (32%), Positives = 55/150 (36%), Gaps = 28/150 (18%)

Query: 536 RPKQPAPLRRAMQGGPAGYRAGLAALRTP------PPAPAGNAGTGTGARKRPEGGRGAR 589
           +P Q AP     Q  PA      AA   P      P AP      G     R     G  
Sbjct: 280 QPSQAAPAEGISQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLP 339

Query: 590 YPCGSSSRVAVPSKEPAGPRAQRNLLPLLPLLAPSRWWG-GKVCEVAVSLESPASG---- 644
            PC     VA P    AGP+ Q  L P  P    S WWG G+  +VA +   P +G    
Sbjct: 340 GPCA----VAQPGPAQAGPQGQGVLAP--PTSQGSPWWGWGRGPQVAGAAWEPQAGAAPP 393

Query: 645 -------EGAEQVQREGQPAP----QSPAP 663
                    A Q Q +G PAP    Q PAP
Sbjct: 394 PQPAPPDASARQGQMQGIPAPSQALQEPAP 423


>gi|239744246 PREDICTED: hypothetical protein XP_002343082 [Homo
           sapiens]
          Length = 483

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 48/150 (32%), Positives = 55/150 (36%), Gaps = 28/150 (18%)

Query: 536 RPKQPAPLRRAMQGGPAGYRAGLAALRTP------PPAPAGNAGTGTGARKRPEGGRGAR 589
           +P Q AP     Q  PA      AA   P      P AP      G     R     G  
Sbjct: 280 QPSQAAPAEGISQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLP 339

Query: 590 YPCGSSSRVAVPSKEPAGPRAQRNLLPLLPLLAPSRWWG-GKVCEVAVSLESPASG---- 644
            PC     VA P    AGP+ Q  L P  P    S WWG G+  +VA +   P +G    
Sbjct: 340 GPCA----VAQPGPAQAGPQGQGVLAP--PTSQGSPWWGWGRGPQVAGAAWEPQAGAAPP 393

Query: 645 -------EGAEQVQREGQPAP----QSPAP 663
                    A Q Q +G PAP    Q PAP
Sbjct: 394 PQPAPPDASARQGQMQGIPAPSQALQEPAP 423


>gi|239744244 PREDICTED: similar to double homeobox, 4 [Homo
           sapiens]
          Length = 483

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 48/150 (32%), Positives = 55/150 (36%), Gaps = 28/150 (18%)

Query: 536 RPKQPAPLRRAMQGGPAGYRAGLAALRTP------PPAPAGNAGTGTGARKRPEGGRGAR 589
           +P Q AP     Q  PA      AA   P      P AP      G     R     G  
Sbjct: 280 QPSQAAPAEGISQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLP 339

Query: 590 YPCGSSSRVAVPSKEPAGPRAQRNLLPLLPLLAPSRWWG-GKVCEVAVSLESPASG---- 644
            PC     VA P    AGP+ Q  L P  P    S WWG G+  +VA +   P +G    
Sbjct: 340 GPCA----VAQPGPAQAGPQGQGVLAP--PTSQGSPWWGWGRGPQVAGAAWEPQAGAAPP 393

Query: 645 -------EGAEQVQREGQPAP----QSPAP 663
                    A Q Q +G PAP    Q PAP
Sbjct: 394 PQPAPPDASARQGQMQGIPAPSQALQEPAP 423


>gi|239744242 PREDICTED: similar to double homeobox, 4 [Homo
           sapiens]
          Length = 483

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 48/150 (32%), Positives = 55/150 (36%), Gaps = 28/150 (18%)

Query: 536 RPKQPAPLRRAMQGGPAGYRAGLAALRTP------PPAPAGNAGTGTGARKRPEGGRGAR 589
           +P Q AP     Q  PA      AA   P      P AP      G     R     G  
Sbjct: 280 QPSQAAPAEGISQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLP 339

Query: 590 YPCGSSSRVAVPSKEPAGPRAQRNLLPLLPLLAPSRWWG-GKVCEVAVSLESPASG---- 644
            PC     VA P    AGP+ Q  L P  P    S WWG G+  +VA +   P +G    
Sbjct: 340 GPCA----VAQPGPAQAGPQGQGVLAP--PTSQGSPWWGWGRGPQVAGAAWEPQAGAAPP 393

Query: 645 -------EGAEQVQREGQPAP----QSPAP 663
                    A Q Q +G PAP    Q PAP
Sbjct: 394 PQPAPPDASARQGQMQGIPAPSQALQEPAP 423


>gi|239744240 PREDICTED: similar to double homeobox, 4 [Homo
           sapiens]
          Length = 483

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 48/150 (32%), Positives = 55/150 (36%), Gaps = 28/150 (18%)

Query: 536 RPKQPAPLRRAMQGGPAGYRAGLAALRTP------PPAPAGNAGTGTGARKRPEGGRGAR 589
           +P Q AP     Q  PA      AA   P      P AP      G     R     G  
Sbjct: 280 QPSQAAPAEGISQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLP 339

Query: 590 YPCGSSSRVAVPSKEPAGPRAQRNLLPLLPLLAPSRWWG-GKVCEVAVSLESPASG---- 644
            PC     VA P    AGP+ Q  L P  P    S WWG G+  +VA +   P +G    
Sbjct: 340 GPCA----VAQPGPAQAGPQGQGVLAP--PTSQGSPWWGWGRGPQVAGAAWEPQAGAAPP 393

Query: 645 -------EGAEQVQREGQPAP----QSPAP 663
                    A Q Q +G PAP    Q PAP
Sbjct: 394 PQPAPPDASARQGQMQGIPAPSQALQEPAP 423


>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
           [Homo sapiens]
          Length = 1412

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 53/231 (22%), Positives = 84/231 (36%), Gaps = 14/231 (6%)

Query: 437 GAHQQVGEGADDEGQSPHVLPLHGRQQGAGAGGMSRRLTAARVPLQRPAAAAASSSAAAA 496
           G  ++  + + +E  S    P   +  G      +    A   P +  A A    +  AA
Sbjct: 327 GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAA 386

Query: 497 AASKLGGA---GPGSAEKADRHRRLLERRGQASGNPDTLRQTRPKQPAPLRRAMQGGPAG 553
           A  ++G        S+E++D  R  L     A   P  L ++   +PA     M  GP G
Sbjct: 387 AQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKP--LGKSPQVKPAS---TMGMGPLG 441

Query: 554 YRAGLAALRTPPPAPAGNAGTGTGARKRPEGGRGARYPCGSSSRVAVPSK-EPAGPRAQR 612
             AG       PP   G A       K  E    +      SS   VP+   PA  ++  
Sbjct: 442 KGAGPV-----PPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLG 496

Query: 613 NLLPLLPLLAPSRWWGGKVCEVAVSLESPASGEGAEQVQREGQPAPQSPAP 663
           N+L   P  +P++    K   VAV +++    + +E  +     A    AP
Sbjct: 497 NILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAP 547


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
           [Homo sapiens]
          Length = 1451

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 53/231 (22%), Positives = 84/231 (36%), Gaps = 14/231 (6%)

Query: 437 GAHQQVGEGADDEGQSPHVLPLHGRQQGAGAGGMSRRLTAARVPLQRPAAAAASSSAAAA 496
           G  ++  + + +E  S    P   +  G      +    A   P +  A A    +  AA
Sbjct: 404 GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAA 463

Query: 497 AASKLGGA---GPGSAEKADRHRRLLERRGQASGNPDTLRQTRPKQPAPLRRAMQGGPAG 553
           A  ++G        S+E++D  R  L     A   P  L ++   +PA     M  GP G
Sbjct: 464 AQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKP--LGKSPQVKPAS---TMGMGPLG 518

Query: 554 YRAGLAALRTPPPAPAGNAGTGTGARKRPEGGRGARYPCGSSSRVAVPSK-EPAGPRAQR 612
             AG       PP   G A       K  E    +      SS   VP+   PA  ++  
Sbjct: 519 KGAGPV-----PPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLG 573

Query: 613 NLLPLLPLLAPSRWWGGKVCEVAVSLESPASGEGAEQVQREGQPAPQSPAP 663
           N+L   P  +P++    K   VAV +++    + +E  +     A    AP
Sbjct: 574 NILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAP 624


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
           [Homo sapiens]
          Length = 1488

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 53/231 (22%), Positives = 84/231 (36%), Gaps = 14/231 (6%)

Query: 437 GAHQQVGEGADDEGQSPHVLPLHGRQQGAGAGGMSRRLTAARVPLQRPAAAAASSSAAAA 496
           G  ++  + + +E  S    P   +  G      +    A   P +  A A    +  AA
Sbjct: 404 GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAA 463

Query: 497 AASKLGGA---GPGSAEKADRHRRLLERRGQASGNPDTLRQTRPKQPAPLRRAMQGGPAG 553
           A  ++G        S+E++D  R  L     A   P  L ++   +PA     M  GP G
Sbjct: 464 AQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKP--LGKSPQVKPAS---TMGMGPLG 518

Query: 554 YRAGLAALRTPPPAPAGNAGTGTGARKRPEGGRGARYPCGSSSRVAVPSK-EPAGPRAQR 612
             AG       PP   G A       K  E    +      SS   VP+   PA  ++  
Sbjct: 519 KGAGPV-----PPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLG 573

Query: 613 NLLPLLPLLAPSRWWGGKVCEVAVSLESPASGEGAEQVQREGQPAPQSPAP 663
           N+L   P  +P++    K   VAV +++    + +E  +     A    AP
Sbjct: 574 NILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAP 624


>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
           [Homo sapiens]
          Length = 1411

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 53/231 (22%), Positives = 84/231 (36%), Gaps = 14/231 (6%)

Query: 437 GAHQQVGEGADDEGQSPHVLPLHGRQQGAGAGGMSRRLTAARVPLQRPAAAAASSSAAAA 496
           G  ++  + + +E  S    P   +  G      +    A   P +  A A    +  AA
Sbjct: 327 GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAA 386

Query: 497 AASKLGGA---GPGSAEKADRHRRLLERRGQASGNPDTLRQTRPKQPAPLRRAMQGGPAG 553
           A  ++G        S+E++D  R  L     A   P  L ++   +PA     M  GP G
Sbjct: 387 AQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKP--LGKSPQVKPAS---TMGMGPLG 441

Query: 554 YRAGLAALRTPPPAPAGNAGTGTGARKRPEGGRGARYPCGSSSRVAVPSK-EPAGPRAQR 612
             AG       PP   G A       K  E    +      SS   VP+   PA  ++  
Sbjct: 442 KGAGPV-----PPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLG 496

Query: 613 NLLPLLPLLAPSRWWGGKVCEVAVSLESPASGEGAEQVQREGQPAPQSPAP 663
           N+L   P  +P++    K   VAV +++    + +E  +     A    AP
Sbjct: 497 NILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAP 547


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
           [Homo sapiens]
          Length = 1450

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 53/231 (22%), Positives = 84/231 (36%), Gaps = 14/231 (6%)

Query: 437 GAHQQVGEGADDEGQSPHVLPLHGRQQGAGAGGMSRRLTAARVPLQRPAAAAASSSAAAA 496
           G  ++  + + +E  S    P   +  G      +    A   P +  A A    +  AA
Sbjct: 404 GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAA 463

Query: 497 AASKLGGA---GPGSAEKADRHRRLLERRGQASGNPDTLRQTRPKQPAPLRRAMQGGPAG 553
           A  ++G        S+E++D  R  L     A   P  L ++   +PA     M  GP G
Sbjct: 464 AQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKP--LGKSPQVKPAS---TMGMGPLG 518

Query: 554 YRAGLAALRTPPPAPAGNAGTGTGARKRPEGGRGARYPCGSSSRVAVPSK-EPAGPRAQR 612
             AG       PP   G A       K  E    +      SS   VP+   PA  ++  
Sbjct: 519 KGAGPV-----PPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLG 573

Query: 613 NLLPLLPLLAPSRWWGGKVCEVAVSLESPASGEGAEQVQREGQPAPQSPAP 663
           N+L   P  +P++    K   VAV +++    + +E  +     A    AP
Sbjct: 574 NILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAP 624


>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
           [Homo sapiens]
          Length = 958

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 53/231 (22%), Positives = 84/231 (36%), Gaps = 14/231 (6%)

Query: 437 GAHQQVGEGADDEGQSPHVLPLHGRQQGAGAGGMSRRLTAARVPLQRPAAAAASSSAAAA 496
           G  ++  + + +E  S    P   +  G      +    A   P +  A A    +  AA
Sbjct: 404 GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAA 463

Query: 497 AASKLGGA---GPGSAEKADRHRRLLERRGQASGNPDTLRQTRPKQPAPLRRAMQGGPAG 553
           A  ++G        S+E++D  R  L     A   P  L ++   +PA     M  GP G
Sbjct: 464 AQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKP--LGKSPQVKPAS---TMGMGPLG 518

Query: 554 YRAGLAALRTPPPAPAGNAGTGTGARKRPEGGRGARYPCGSSSRVAVPSK-EPAGPRAQR 612
             AG       PP   G A       K  E    +      SS   VP+   PA  ++  
Sbjct: 519 KGAGPV-----PPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLG 573

Query: 613 NLLPLLPLLAPSRWWGGKVCEVAVSLESPASGEGAEQVQREGQPAPQSPAP 663
           N+L   P  +P++    K   VAV +++    + +E  +     A    AP
Sbjct: 574 NILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAP 624


>gi|157785645 SPEG complex locus [Homo sapiens]
          Length = 3267

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 64/240 (26%), Positives = 81/240 (33%), Gaps = 35/240 (14%)

Query: 447  DDEGQSPHVLPLHGRQQGAGAG---GMSRRLTAARVPLQRPAAAAASSSAAAAAASKL-- 501
            D E  SP  LP  G++  AGA    G  RR ++A   L R            AA+ +L  
Sbjct: 1983 DQEAPSPEALPSPGQEPAAGASPRRGELRRGSSAESALPRAGPRELGRGLHKAASVELPQ 2042

Query: 502  -------------GGAGPGS-AEKADRHRRLLERRGQASGNPDTLRQTRPKQPAPLRRAM 547
                         GG G G  A++    R+ L R G   G    LR        PL  ++
Sbjct: 2043 RRSPSPGATRLARGGLGEGEYAQRLQALRQRLLRGGPEDGKVSGLR-------GPLLESL 2095

Query: 548  QGGPAGYRAGLAALRTPPP---APAGNAGTGTGARKRPEGGRGARYPCGSSSRVAVPSKE 604
             G     R   AA     P    P  N     G +K     +G   P G   R   P + 
Sbjct: 2096 GGRARDPRMARAASSEAAPHHQPPLEN----RGLQKSSSFSQGEAEPRGRHRRAGAPLEI 2151

Query: 605  PAGPRAQRNLLPLLPLLAPSRWWGGKVCEVAVSLESPASGEGAEQVQREGQPAPQSPAPQ 664
            P      R L     L A S            S   P++ + AE        APQ PAPQ
Sbjct: 2152 PVARLGARRLQESPSLSALSE--AQPSSPARPSAPKPSTPKSAEPSATTPSDAPQPPAPQ 2209


>gi|153945765 mitogen-activated protein kinase kinase kinase 1 [Homo
           sapiens]
          Length = 1512

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 47/141 (33%), Positives = 58/141 (41%), Gaps = 19/141 (13%)

Query: 487 AAASSSAAAAAASKLGGAGPGSAEKADRHRRLLERRGQASGNPDTLRQTRPKQPAPLRRA 546
           A  +SSA AAAA  L  AG G  E+AD  RR L  R   S   D L    P+QP  L  +
Sbjct: 30  ALKASSAPAAAAGLLREAGSGGRERADWRRRQL--RKVRSVELDQL----PEQPLFLAAS 83

Query: 547 MQGGPAGYRAGLAALRTPPPAPAGNAGTGTGARK---RPEGGRGARYPCGSSSRVAVPSK 603
                       A+  +P P PA  AG+GTG +     P  G  +R     +  VA P  
Sbjct: 84  PP----------ASSTSPSPEPADAAGSGTGFQPVAVPPPHGAASRGGAHLTESVAAPDS 133

Query: 604 EPAGPRAQRNLLPLLPLLAPS 624
             + P A        P   PS
Sbjct: 134 GASSPAAAEPGEKRAPAAEPS 154


>gi|239742468 PREDICTED: double homeobox, 4-like [Homo sapiens]
          Length = 485

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 48/152 (31%), Positives = 55/152 (36%), Gaps = 30/152 (19%)

Query: 536 RPKQPAPLRRAMQGGPAGYRAGLAALRTP------PPAPAGNAGTGTGARKRPEGGRGAR 589
           +P Q AP     Q  PA      AA   P      P AP      G     R     G  
Sbjct: 280 QPSQAAPAEGVSQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLP 339

Query: 590 YPCGSSSRVAVPSKEPAGPRAQRNLLPLLPLLAPSRWWG-GKVCEVAVSLESPASG---- 644
            PC     VA P    AGP+ Q  L P  P    S WWG G+  +VA +   P +G    
Sbjct: 340 GPCA----VAQPGPAQAGPQGQGVLAP--PTSQGSPWWGWGRGPQVAGAAWEPQAGAAPP 393

Query: 645 ---------EGAEQVQREGQPAP----QSPAP 663
                      A Q Q +G PAP    Q PAP
Sbjct: 394 PQPAPPDASASARQGQMQGIPAPSQALQEPAP 425


>gi|194272172 double homeobox, 4 [Homo sapiens]
          Length = 485

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 48/152 (31%), Positives = 55/152 (36%), Gaps = 30/152 (19%)

Query: 536 RPKQPAPLRRAMQGGPAGYRAGLAALRTP------PPAPAGNAGTGTGARKRPEGGRGAR 589
           +P Q AP     Q  PA      AA   P      P AP      G     R     G  
Sbjct: 280 QPSQAAPAEGVSQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLP 339

Query: 590 YPCGSSSRVAVPSKEPAGPRAQRNLLPLLPLLAPSRWWG-GKVCEVAVSLESPASG---- 644
            PC     VA P    AGP+ Q  L P  P    S WWG G+  +VA +   P +G    
Sbjct: 340 GPCA----VAQPGPAQAGPQGQGVLAP--PTSQGSPWWGWGRGPQVAGAAWEPQAGAAPP 393

Query: 645 ---------EGAEQVQREGQPAP----QSPAP 663
                      A Q Q +G PAP    Q PAP
Sbjct: 394 PQPAPPDASASARQGQMQGIPAPSQALQEPAP 425


>gi|194272217 double homeobox, 4-like [Homo sapiens]
          Length = 485

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 48/152 (31%), Positives = 55/152 (36%), Gaps = 30/152 (19%)

Query: 536 RPKQPAPLRRAMQGGPAGYRAGLAALRTP------PPAPAGNAGTGTGARKRPEGGRGAR 589
           +P Q AP     Q  PA      AA   P      P AP      G     R     G  
Sbjct: 280 QPSQAAPAEGVSQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLP 339

Query: 590 YPCGSSSRVAVPSKEPAGPRAQRNLLPLLPLLAPSRWWG-GKVCEVAVSLESPASG---- 644
            PC     VA P    AGP+ Q  L P  P    S WWG G+  +VA +   P +G    
Sbjct: 340 GPCA----VAQPGPAQAGPQGQGVLAP--PTSQGSPWWGWGRGPQVAGAAWEPQAGAAPP 393

Query: 645 ---------EGAEQVQREGQPAP----QSPAP 663
                      A Q Q +G PAP    Q PAP
Sbjct: 394 PQPAPPDASASARQGQMQGIPAPSQALQEPAP 425


>gi|194272216 double homeobox, 4-like [Homo sapiens]
          Length = 485

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 48/152 (31%), Positives = 55/152 (36%), Gaps = 30/152 (19%)

Query: 536 RPKQPAPLRRAMQGGPAGYRAGLAALRTP------PPAPAGNAGTGTGARKRPEGGRGAR 589
           +P Q AP     Q  PA      AA   P      P AP      G     R     G  
Sbjct: 280 QPSQAAPAEGVSQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLP 339

Query: 590 YPCGSSSRVAVPSKEPAGPRAQRNLLPLLPLLAPSRWWG-GKVCEVAVSLESPASG---- 644
            PC     VA P    AGP+ Q  L P  P    S WWG G+  +VA +   P +G    
Sbjct: 340 GPCA----VAQPGPAQAGPQGQGVLAP--PTSQGSPWWGWGRGPQVAGAAWEPQAGAAPP 393

Query: 645 ---------EGAEQVQREGQPAP----QSPAP 663
                      A Q Q +G PAP    Q PAP
Sbjct: 394 PQPAPPDASASARQGQMQGIPAPSQALQEPAP 425


>gi|194272215 double homeobox, 4-like [Homo sapiens]
          Length = 485

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 48/152 (31%), Positives = 55/152 (36%), Gaps = 30/152 (19%)

Query: 536 RPKQPAPLRRAMQGGPAGYRAGLAALRTP------PPAPAGNAGTGTGARKRPEGGRGAR 589
           +P Q AP     Q  PA      AA   P      P AP      G     R     G  
Sbjct: 280 QPSQAAPAEGVSQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLP 339

Query: 590 YPCGSSSRVAVPSKEPAGPRAQRNLLPLLPLLAPSRWWG-GKVCEVAVSLESPASG---- 644
            PC     VA P    AGP+ Q  L P  P    S WWG G+  +VA +   P +G    
Sbjct: 340 GPCA----VAQPGPAQAGPQGQGVLAP--PTSQGSPWWGWGRGPQVAGAAWEPQAGAAPP 393

Query: 645 ---------EGAEQVQREGQPAP----QSPAP 663
                      A Q Q +G PAP    Q PAP
Sbjct: 394 PQPAPPDASASARQGQMQGIPAPSQALQEPAP 425


>gi|194272192 double homeobox, 4-like [Homo sapiens]
          Length = 485

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 48/152 (31%), Positives = 55/152 (36%), Gaps = 30/152 (19%)

Query: 536 RPKQPAPLRRAMQGGPAGYRAGLAALRTP------PPAPAGNAGTGTGARKRPEGGRGAR 589
           +P Q AP     Q  PA      AA   P      P AP      G     R     G  
Sbjct: 280 QPSQAAPAEGVSQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLP 339

Query: 590 YPCGSSSRVAVPSKEPAGPRAQRNLLPLLPLLAPSRWWG-GKVCEVAVSLESPASG---- 644
            PC     VA P    AGP+ Q  L P  P    S WWG G+  +VA +   P +G    
Sbjct: 340 GPCA----VAQPGPAQAGPQGQGVLAP--PTSQGSPWWGWGRGPQVAGAAWEPQAGAAPP 393

Query: 645 ---------EGAEQVQREGQPAP----QSPAP 663
                      A Q Q +G PAP    Q PAP
Sbjct: 394 PQPAPPDASASARQGQMQGIPAPSQALQEPAP 425


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.135    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,429,557
Number of Sequences: 37866
Number of extensions: 1923952
Number of successful extensions: 12540
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 691
Number of HSP's that attempted gapping in prelim test: 10622
Number of HSP's gapped (non-prelim): 2174
length of query: 692
length of database: 18,247,518
effective HSP length: 109
effective length of query: 583
effective length of database: 14,120,124
effective search space: 8232032292
effective search space used: 8232032292
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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