Search of human proteins with 239582765

Search of human proteins with 239582765

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239582765 ral guanine nucleotide dissociation
stimulator-like 3 isoform 1 [Homo sapiens]
         (716 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239582765 ral guanine nucleotide dissociation stimulator-like...  1432   0.0  
gi|239582763 ral guanine nucleotide dissociation stimulator-like...  1413   0.0  
gi|93102367 ral guanine nucleotide dissociation stimulator-like ...   447   e-125
gi|4758532 ral guanine nucleotide dissociation stimulator-like 2...   387   e-107
gi|24307909 ral guanine nucleotide dissociation stimulator isofo...   379   e-105
gi|108796058 ral guanine nucleotide dissociation stimulator isof...   379   e-105
gi|23957680 ral guanine nucleotide dissociation stimulator-like ...   180   5e-45
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ...   125   2e-28
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa...   120   3e-27
gi|224586880 Ras protein-specific guanine nucleotide-releasing f...   115   1e-25
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa...   115   1e-25
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa...   115   1e-25
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo...   111   3e-24
gi|15529996 son of sevenless homolog 1 [Homo sapiens]                 105   1e-22
gi|154689780 son of sevenless homolog 2 [Homo sapiens]                104   2e-22
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul...    89   1e-17
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom...    86   9e-17
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom...    86   9e-17
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg...    86   2e-16
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu...    86   2e-16
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]              82   2e-15
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]             82   2e-15
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]             82   2e-15
gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]    74   4e-13
gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapi...    74   4e-13
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi...    74   4e-13
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi...    73   1e-12
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]     69   2e-11
gi|40255197 RasGEF domain family, member 1C [Homo sapiens]             69   2e-11
gi|117168263 RasGEF domain family, member 1A [Homo sapiens]            68   3e-11

>gi|239582765 ral guanine nucleotide dissociation stimulator-like 3
           isoform 1 [Homo sapiens]
          Length = 716

 Score = 1432 bits (3706), Expect = 0.0
 Identities = 716/716 (100%), Positives = 716/716 (100%)

Query: 1   MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLH 60
           MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLH
Sbjct: 1   MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLH 60

Query: 61  YRTSKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPP 120
           YRTSKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPP
Sbjct: 61  YRTSKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPP 120

Query: 121 PPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAP 180
           PPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAP
Sbjct: 121 PPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAP 180

Query: 181 GSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQG 240
           GSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQG
Sbjct: 181 GSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQG 240

Query: 241 PQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNT 300
           PQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNT
Sbjct: 241 PQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNT 300

Query: 301 VTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKR 360
           VTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKR
Sbjct: 301 VTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKR 360

Query: 361 SWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGP 420
           SWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGP
Sbjct: 361 SWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGP 420

Query: 421 VPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPI 480
           VPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPI
Sbjct: 421 VPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPI 480

Query: 481 LAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGS 540
           LAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGS
Sbjct: 481 LAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGS 540

Query: 541 PGDPSSPTSSLCISPSVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRP 600
           PGDPSSPTSSLCISPSVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRP
Sbjct: 541 PGDPSSPTSSLCISPSVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRP 600

Query: 601 FALPLGSPRIPLPAQQSSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVP 660
           FALPLGSPRIPLPAQQSSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVP
Sbjct: 601 FALPLGSPRIPLPAQQSSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVP 660

Query: 661 QPWACDYQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS 716
           QPWACDYQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS
Sbjct: 661 QPWACDYQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS 716


>gi|239582763 ral guanine nucleotide dissociation stimulator-like 3
           isoform 2 [Homo sapiens]
          Length = 710

 Score = 1413 bits (3657), Expect = 0.0
 Identities = 710/716 (99%), Positives = 710/716 (99%), Gaps = 6/716 (0%)

Query: 1   MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLH 60
           MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLH
Sbjct: 1   MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLH 60

Query: 61  YRTSKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPP 120
           YRTSKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPP
Sbjct: 61  YRTSKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPP 120

Query: 121 PPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAP 180
           PPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAP
Sbjct: 121 PPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAP 180

Query: 181 GSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQG 240
           GSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQG
Sbjct: 181 GSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQG 240

Query: 241 PQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNT 300
           PQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNT
Sbjct: 241 PQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNT 300

Query: 301 VTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKR 360
           VTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKR
Sbjct: 301 VTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKR 360

Query: 361 SWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGP 420
           SWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGP
Sbjct: 361 SWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGP 420

Query: 421 VPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPI 480
           VPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPI
Sbjct: 421 VPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPI 480

Query: 481 LAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGS 540
           LAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGS
Sbjct: 481 LAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGS 540

Query: 541 PGDPSSPTSSLCISPSVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRP 600
           PGDPSSPTS      SVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRP
Sbjct: 541 PGDPSSPTS------SVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRP 594

Query: 601 FALPLGSPRIPLPAQQSSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVP 660
           FALPLGSPRIPLPAQQSSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVP
Sbjct: 595 FALPLGSPRIPLPAQQSSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVP 654

Query: 661 QPWACDYQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS 716
           QPWACDYQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS
Sbjct: 655 QPWACDYQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS 710


>gi|93102367 ral guanine nucleotide dissociation stimulator-like 1
           [Homo sapiens]
          Length = 803

 Score =  447 bits (1151), Expect = e-125
 Identities = 289/742 (38%), Positives = 413/742 (55%), Gaps = 71/742 (9%)

Query: 14  LQDWGEETEDGAVYSVSLRRQRSQRRSPAE----GPGGSQAPSPIANTFLHYRTSKVRVL 69
           +QDWGEE E+GAVY V+L+R + Q+ +       G  G Q P    +T   Y T K+R +
Sbjct: 47  IQDWGEEVEEGAVYHVTLKRVQIQQAANKGARWLGVEGDQLPP--GHTVSQYETCKIRTI 104

Query: 70  RAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPPPPPGVEIKK 129
           +A  LE+LV  L+    + D +++  FL+TYR F  T  +L  LL        P  E   
Sbjct: 105 KAGTLEKLVENLLTAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTSPNCEEDG 164

Query: 130 TAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAEAQKAE 189
           +     S      A+ S+L +WL    +DFR+PP    L  +  +L    PGS   ++A+
Sbjct: 165 SQSSSESKMVIRNAIASILRAWLDQCAEDFREPPHFPCLQKLLDYLTRMMPGSDPERRAQ 224

Query: 190 KLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQGPQLLDFSVD 249
            LLE F     ++QE E      G P     S         EEEE    +  +   FS D
Sbjct: 225 NLLEQF-----QKQEVETDN---GLPNTISFS-------LEEEEELEGGESAEFTCFSED 269

Query: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309
            VAEQLT +D +LF KV  + CLG +WS+RD+      +PT+RAT++QFNT+T CV+ ++
Sbjct: 270 LVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVVSTI 329

Query: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369
           LG   L   QRA+ +EKWI IA  CR L+NFSSLRAI+SALQSN IYRLK++W AV R+ 
Sbjct: 330 LGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVPRDR 389

Query: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGS-------QEEDNTPGSLPSKPP----P 418
           +  F +LS IFSD NNHL+SRE+L +E  ++ +       + +  T   L  +       
Sbjct: 390 MLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMGVMQ 449

Query: 419 GPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHP 478
           G VPYLGTFLTDL MLDTAL D +EG LINFEKRR+E+E++A+I+ LQ  C SY ++P  
Sbjct: 450 GTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQSACNSYCMTPDQ 509

Query: 479 PILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLS------------ 526
             +     Q  LTEE+SY LS  IE  A +  +SP+ R+  S+ KRLS            
Sbjct: 510 KFIQWFQRQQLLTEEESYALSCEIEAAADASTTSPKPRK--SMVKRLSLLFLGSDMITSP 567

Query: 527 AKLAREKSSSPSGSPGDPSSPTS-SLCIS-------PSVSPGSPPSSPRSRDAPAGSPPA 578
                +  S+ SGS G+     S S C S        S++P   P  P+ + + + S  +
Sbjct: 568 TPTKEQPKSTASGSSGESMDSVSVSSCESNHSEAEEGSITPMDTPDEPQKKLSESSSSCS 627

Query: 579 SPGPQGPSTKLPLSLDLPSPRPFALPLGSPRI----------------PLPAQQSSEARV 622
           S      ++    SL  P   P +    +P+I                P+  QQ+ +  +
Sbjct: 628 SIHSMDTNSSGMSSLINPLSSPPSCN-NNPKIHKRSVSVTSITSTVLPPVYNQQNEDTCI 686

Query: 623 IRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGDRVLLIP 682
           IR+S+++++GN+Y+SI+LTSQDK P+V++RA+ KHN+    A +Y+L QV+  D+ L+IP
Sbjct: 687 IRISVEDNNGNMYKSIMLTSQDKTPAVIQRAMLKHNLDSDPAEEYELVQVISEDKELVIP 746

Query: 683 DNANVFYAMSPVAPRDFMLRRK 704
           D+ANVFYAM+     DF+LR+K
Sbjct: 747 DSANVFYAMNSQVNFDFILRKK 768


>gi|4758532 ral guanine nucleotide dissociation stimulator-like 2
           [Homo sapiens]
          Length = 777

 Score =  387 bits (994), Expect = e-107
 Identities = 277/735 (37%), Positives = 376/735 (51%), Gaps = 96/735 (13%)

Query: 12  APLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLHYRTSKVRVLRA 71
           AP+  W EE EDGAV++V+ R+ R         P     P P   +         R LRA
Sbjct: 53  APVSVWDEE-EDGAVFTVTSRQYR---------PLDPLVPMPPPRSS--------RRLRA 94

Query: 72  ARLERLVGELVFGDRE-QDPSFMPAFLATYRTFVPTACLLGFLLPPMPP-PPPPGVEIKK 129
             LE LV  L+       D SFM AFLAT+R F  T  LLG +   +      P  E+++
Sbjct: 95  GTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPALLGLMADRLEALESHPTDELER 154

Query: 130 TAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFL---GWAAPGSAEAQ 186
           T              +SVL +WL  HP+DF    A   L  + +FL   G+AA       
Sbjct: 155 TT----------EVAISVLSTWLASHPEDFGSE-AKGQLDRLESFLLQTGYAAGKGVGGG 203

Query: 187 KAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQGPQLLDF 246
            A     D +       + + P +   P  +A   DP +                 +L F
Sbjct: 204 SA-----DLIRNLRSRVDPQAPDL---PKPLALPGDPPADPT-------------DVLVF 242

Query: 247 SVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVL 306
             D +AEQLTL+D ELF  +   +CLG +W  RDRPG +   P+VRATV QFN V G V+
Sbjct: 243 LADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVV 302

Query: 307 GSVLGA------PG------LAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNP 354
            SVLGA      PG      L  PQRA+ LEKWIR+A+ CR LRNFSS+ A++SALQS+P
Sbjct: 303 SSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSP 362

Query: 355 IYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPS 414
           I+RL+ +WG  +R+ L  F  L QIFS+E+N+  SRE+L QE   +   E  +       
Sbjct: 363 IHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSG 422

Query: 415 KPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTL 474
               G VPYLGTFL DLVMLD A  D LE   INF+KRRKE+ +L+ +++LQ  C+ Y L
Sbjct: 423 SRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNL 482

Query: 475 SPHPPILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKS 534
            P   I   L     LTE QS+R+S  +EPP +S P +PR+ R   +  + +  L     
Sbjct: 483 QPDHDIQRWLQGLRPLTEAQSHRVSCEVEPPGSSDPPAPRVLRPTLVISQWTEVLGSVGV 542

Query: 535 SSP-----SGSPGDPSSPTSSLCISPSVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKL 589
            +P       S G   +PT+   +   ++      S  S D+   S P+   P  PS   
Sbjct: 543 PTPLVSCDRPSTGGDEAPTTPAPLLTRLAQHMKWPSVSSLDSALESSPSLHSPADPS--- 599

Query: 590 PLSLDLPSPRPF-----ALPLGSPRIPLPAQQS--------------SEARVIRVSID-N 629
            LS    SPRP      +   GSP      + S              S+ R+IRV ++  
Sbjct: 600 HLSPPASSPRPSRGHRRSASCGSPLSGGAEEASGGTGYGGEGSGPGASDCRIIRVQMELG 659

Query: 630 DHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGDRVLLIPDNANVFY 689
           + G++Y+SIL+TSQDKAPSV+ R L+K+N     A +Y+L Q+LPG+R L IP +ANVFY
Sbjct: 660 EDGSVYKSILVTSQDKAPSVISRVLKKNNRDSAVASEYELVQLLPGERELTIPASANVFY 719

Query: 690 AMSPVAPRDFMLRRK 704
           AM   A  DF+LR++
Sbjct: 720 AMDG-ASHDFLLRQR 733


>gi|24307909 ral guanine nucleotide dissociation stimulator isoform
           1 [Homo sapiens]
          Length = 914

 Score =  379 bits (974), Expect = e-105
 Identities = 239/553 (43%), Positives = 318/553 (57%), Gaps = 43/553 (7%)

Query: 198 EAEREQEEEPPQVWTGPPRVAQTSDPDSS-EACAEEEEGLMPQGPQLLDFSVDEVAEQLT 256
           E   EQ+  P Q     P  A       S  +    E GL  + P LL F  D VAEQ T
Sbjct: 336 EPAPEQDPAPSQTLELEPAPAPVPSLQPSWPSPVVAENGLSEEKPHLLVFPPDLVAEQFT 395

Query: 257 LIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLA 316
           L+D ELF KV  Y CLGS+WSQRD+ G    +PT+RATV QFN+V  CV+ + LG     
Sbjct: 396 LMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTK 455

Query: 317 APQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKL 376
           AP RA+ +E WI +A+ CR L+NFSSL AILSALQSN I+RLK++W  VSR+    F+KL
Sbjct: 456 APDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKL 515

Query: 377 SQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPP-----GPVPYLGTFLTDL 431
           S+IFSDENN+  SRE+L +E  ++ +  E N P     +P       G VPYLGTFLTDL
Sbjct: 516 SEIFSDENNYSLSRELLIKEGTSKFATLEMN-PKRAQKRPKETGIIQGTVPYLGTFLTDL 574

Query: 432 VMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLT 491
           VMLDTA+ D L G LINFEKRRKE+E++A+I+ LQ  C +Y+++P     A   A  +L+
Sbjct: 575 VMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLS 634

Query: 492 EEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGSPGDPSSPT--- 548
           E +SY LS  +EPP+ S  ++ R ++  ++ KR S + A     S SGS    S      
Sbjct: 635 ETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSDRQAPSTELSTSGSSHSKSCDQLRC 694

Query: 549 ----SSLCISPSVSPGSPPSS------------PRSRDAPA-----GSPPASPGPQG-PS 586
               SS  I+ ++S  S  SS            P S D         +  +SP   G  S
Sbjct: 695 GPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQEKKFWESASQSSPETSGISS 754

Query: 587 TKLPLSLDLPSPRPFA-----------LPLGSPRIPLPAQQSSEARVIRVSIDNDHGNLY 635
                S    S  P A           L   S  +PL  QQ  +  +IRVS+D D+GN+Y
Sbjct: 755 ASSSTSSSSASTTPVAATRTHKRSVSGLCNSSSALPLYNQQVGDCCIIRVSLDVDNGNMY 814

Query: 636 RSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGDRVLLIPDNANVFYAMSPVA 695
           +SIL+TSQDKAP+V+R+A+ KHN+ +    DY+L Q+L  DR L IP+NANVFYAM+  A
Sbjct: 815 KSILVTSQDKAPAVIRKAMDKHNLEEEEPEDYELLQILSDDRKLKIPENANVFYAMNSTA 874

Query: 696 PRDFMLRRKEGTR 708
             DF+L+++  T+
Sbjct: 875 NYDFVLKKRTFTK 887



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 60/218 (27%), Positives = 98/218 (44%), Gaps = 20/218 (9%)

Query: 15  QDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIA----NTFLHYRTSKVRVLR 70
           Q+ GEE  +G +YS+SLR+ +          GG++    +     +    Y T KVR ++
Sbjct: 65  QEIGEELINGVIYSISLRKVQLHH-------GGNKGQRWLGYENESALNLYETCKVRTVK 117

Query: 71  AARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLL------PPMPPPPPPG 124
           A  LE+LV  LV   +  D S++  FL TYR F  T  +L  L         +      G
Sbjct: 118 AGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYG 177

Query: 125 VEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAE 184
             +  +       ++   A+ S+LG+WL  + +DF  PP    L  +  ++    PGS  
Sbjct: 178 CILPYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDL 237

Query: 185 AQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSD 222
            ++A  LL   LE +E  + E  P+  +  P +  T +
Sbjct: 238 ERRAHLLLAQ-LEHSEPIEAE--PEALSPVPALKPTPE 272


>gi|108796058 ral guanine nucleotide dissociation stimulator isoform
           2 [Homo sapiens]
          Length = 859

 Score =  379 bits (974), Expect = e-105
 Identities = 239/553 (43%), Positives = 318/553 (57%), Gaps = 43/553 (7%)

Query: 198 EAEREQEEEPPQVWTGPPRVAQTSDPDSS-EACAEEEEGLMPQGPQLLDFSVDEVAEQLT 256
           E   EQ+  P Q     P  A       S  +    E GL  + P LL F  D VAEQ T
Sbjct: 281 EPAPEQDPAPSQTLELEPAPAPVPSLQPSWPSPVVAENGLSEEKPHLLVFPPDLVAEQFT 340

Query: 257 LIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLA 316
           L+D ELF KV  Y CLGS+WSQRD+ G    +PT+RATV QFN+V  CV+ + LG     
Sbjct: 341 LMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTK 400

Query: 317 APQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKL 376
           AP RA+ +E WI +A+ CR L+NFSSL AILSALQSN I+RLK++W  VSR+    F+KL
Sbjct: 401 APDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKL 460

Query: 377 SQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPP-----GPVPYLGTFLTDL 431
           S+IFSDENN+  SRE+L +E  ++ +  E N P     +P       G VPYLGTFLTDL
Sbjct: 461 SEIFSDENNYSLSRELLIKEGTSKFATLEMN-PKRAQKRPKETGIIQGTVPYLGTFLTDL 519

Query: 432 VMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLT 491
           VMLDTA+ D L G LINFEKRRKE+E++A+I+ LQ  C +Y+++P     A   A  +L+
Sbjct: 520 VMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLS 579

Query: 492 EEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGSPGDPSSPT--- 548
           E +SY LS  +EPP+ S  ++ R ++  ++ KR S + A     S SGS    S      
Sbjct: 580 ETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSDRQAPSTELSTSGSSHSKSCDQLRC 639

Query: 549 ----SSLCISPSVSPGSPPSS------------PRSRDAPA-----GSPPASPGPQG-PS 586
               SS  I+ ++S  S  SS            P S D         +  +SP   G  S
Sbjct: 640 GPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQEKKFWESASQSSPETSGISS 699

Query: 587 TKLPLSLDLPSPRPFA-----------LPLGSPRIPLPAQQSSEARVIRVSIDNDHGNLY 635
                S    S  P A           L   S  +PL  QQ  +  +IRVS+D D+GN+Y
Sbjct: 700 ASSSTSSSSASTTPVAATRTHKRSVSGLCNSSSALPLYNQQVGDCCIIRVSLDVDNGNMY 759

Query: 636 RSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGDRVLLIPDNANVFYAMSPVA 695
           +SIL+TSQDKAP+V+R+A+ KHN+ +    DY+L Q+L  DR L IP+NANVFYAM+  A
Sbjct: 760 KSILVTSQDKAPAVIRKAMDKHNLEEEEPEDYELLQILSDDRKLKIPENANVFYAMNSTA 819

Query: 696 PRDFMLRRKEGTR 708
             DF+L+++  T+
Sbjct: 820 NYDFVLKKRTFTK 832



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 60/218 (27%), Positives = 98/218 (44%), Gaps = 20/218 (9%)

Query: 15  QDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIA----NTFLHYRTSKVRVLR 70
           Q+ GEE  +G +YS+SLR+ +          GG++    +     +    Y T KVR ++
Sbjct: 10  QEIGEELINGVIYSISLRKVQLHH-------GGNKGQRWLGYENESALNLYETCKVRTVK 62

Query: 71  AARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLL------PPMPPPPPPG 124
           A  LE+LV  LV   +  D S++  FL TYR F  T  +L  L         +      G
Sbjct: 63  AGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYG 122

Query: 125 VEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAE 184
             +  +       ++   A+ S+LG+WL  + +DF  PP    L  +  ++    PGS  
Sbjct: 123 CILPYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDL 182

Query: 185 AQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSD 222
            ++A  LL   LE +E  + E  P+  +  P +  T +
Sbjct: 183 ERRAHLLLAQ-LEHSEPIEAE--PEALSPVPALKPTPE 217


>gi|23957680 ral guanine nucleotide dissociation stimulator-like 4
           [Homo sapiens]
          Length = 473

 Score =  180 bits (456), Expect = 5e-45
 Identities = 121/346 (34%), Positives = 175/346 (50%), Gaps = 22/346 (6%)

Query: 162 PPAHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTS 221
           PP  +DLG          P S  A      L      A    E  PP     P    ++S
Sbjct: 144 PPLLADLGPA------LEPESPAALGPPGYLHSAPGPAPAPGEGPPPGTVLEPQSAPESS 197

Query: 222 DPDSSEACAEEEEGLMPQGPQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDR 281
            P       +  E L    P +  F    +AEQLTL+D ELF KV L+ECLG +W Q   
Sbjct: 198 CPCRGSVKNQPSEEL----PDMTTFPPRLLAEQLTLMDAELFKKVVLHECLGCIWGQGHL 253

Query: 282 PGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFS 341
            G    +PTVRAT+A FN +T C+  S LG   + A  RA+ +E WI++A+ C  L NFS
Sbjct: 254 KGNEHMAPTVRATIAHFNRLTNCITTSCLGDHSMRARDRARVVEHWIKVARECLSLNNFS 313

Query: 342 SLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEG 401
           S+  I+SAL SNPI +L ++W  VS + +   ++L      + +    R++L +  + + 
Sbjct: 314 SVHVIVSALCSNPIGQLHKTWAGVSSKSMKELKELC-----KKDTAVKRDLLIKAGSFKV 368

Query: 402 SQEEDNTPGSLP---SKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEI 458
           + +E N P  +     +   G VP+LG FLT+L  LD+A+PD L+G   N  KR KE  +
Sbjct: 369 ATQERN-PQRVQMRLRRQKKGVVPFLGDFLTELQRLDSAIPDDLDG---NTNKRSKEVRV 424

Query: 459 LARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQSYRLSRVIEP 504
           L  +Q LQ    +Y L P    +       QL++++SY+LS  +EP
Sbjct: 425 LQEMQLLQVAAMNYRLRPLEKFVTYFTRMEQLSDKESYKLSCQLEP 470


>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
           sapiens]
          Length = 557

 Score =  125 bits (313), Expect = 2e-28
 Identities = 106/368 (28%), Positives = 174/368 (47%), Gaps = 50/368 (13%)

Query: 210 VWTGPPRVAQTSDPDSSEACAEEEEGLMPQGPQLLDFSVDEVAEQLTLIDLELFSKVRLY 269
           V +  P+ + +SD    ++C    +        +L  + +E A Q+TL+D+ +F  ++  
Sbjct: 13  VTSATPQGSSSSDSLEGQSCDYASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPE 72

Query: 270 ECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIR 329
           E     WS++++   A   P V A   +FN V+  V+  +L A  L    RA+ L  +++
Sbjct: 73  ELASCGWSKKEKHSLA---PNVVAFTRRFNQVSFWVVREILTAQTLKI--RAEILSHFVK 127

Query: 330 IAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSS 389
           IA++  EL N  SL +++SALQS PI+RL ++W  ++R+  +TF KL  + S E+N+  +
Sbjct: 128 IAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRT 187

Query: 390 REILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINF 449
           RE +                 SL   P    +PYLG +L DL+ +D+A P    G ++  
Sbjct: 188 REYI----------------RSLKMVP---SIPYLGIYLLDLIYIDSAYP--ASGSIMEN 226

Query: 450 EKRRKEW-EILARIQQLQRRCQSYTLSPHPPI------LAALHAQNQLTEEQSYRLSRVI 502
           E+R  +   IL  I  LQ  C    L+  P +      +  +    +  E+ +Y+LS  I
Sbjct: 227 EQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRI 286

Query: 503 EPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGSPGDPSSPTSSLCISPSVSPGSP 562
           EP +    SSPR+         +S+K   E  + PS   G         C   SV+   P
Sbjct: 287 EPGS----SSPRL---------VSSK---EDLAGPSAGSGSARFSRRPTCPDTSVAGSLP 330

Query: 563 -PSSPRSR 569
            P  PR R
Sbjct: 331 TPPVPRHR 338


>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
            2 [Homo sapiens]
          Length = 1237

 Score =  120 bits (302), Expect = 3e-27
 Identities = 81/259 (31%), Positives = 128/259 (49%), Gaps = 28/259 (10%)

Query: 247  SVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVL 306
            S  E+AEQ+TL+D  +F  +   E LG  W + D+      +P +  T   FN ++  V 
Sbjct: 1002 SAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNER---TPYIMKTSQHFNDMSNLVA 1058

Query: 307  GSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVS 366
              ++    +++  RA  +EKW+ +A  CR L N++ +  I SAL  + IYRLK++W  VS
Sbjct: 1059 SQIMNYADVSS--RANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVS 1116

Query: 367  REPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGT 426
            ++  +   KL +  S E    + RE                   +L +  PP  VPYLG 
Sbjct: 1117 KQTKALMDKLQKTVSSEGRFKNLRE-------------------TLKNCNPPA-VPYLGM 1156

Query: 427  FLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHA 486
            +LTDL  ++   P+  E  L+NF K R    I+  I+Q Q+   SY +   P +   L  
Sbjct: 1157 YLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQ--TSYRIDHQPKVAQYLLD 1214

Query: 487  QNQLTEEQS-YRLSRVIEP 504
            ++ + +E + Y LS  IEP
Sbjct: 1215 KDLIIDEDTLYELSLKIEP 1233



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 35/99 (35%), Positives = 49/99 (49%), Gaps = 18/99 (18%)

Query: 490 LTEEQSYRLSRVIEPP---AASCPSSPRIRRRISLTKRLSAKL-AREKSSSPSGSPGDPS 545
           L + +S RL R    P   A S  SSP   R++SLT  L++K+ A + ++S        S
Sbjct: 713 LVDGKSPRLCRKFSSPPPLAVSRTSSPVRARKLSLTSPLNSKIGALDLTTS--------S 764

Query: 546 SPTSSLCISPSVSPGSPPSS---PRSRDAPAGSPPASPG 581
           SPT++   SP+ SP  PP +   P        SP  SPG
Sbjct: 765 SPTTT-TQSPAASP--PPHTGQIPLDLSRGLSSPEQSPG 800


>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
            1 isoform 3 [Homo sapiens]
          Length = 1257

 Score =  115 bits (288), Expect = 1e-25
 Identities = 97/365 (26%), Positives = 160/365 (43%), Gaps = 53/365 (14%)

Query: 144  VVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQ 203
            V++VL  W+  H QDF     + +L                  K    LE+ + + E   
Sbjct: 938  VLNVLRHWVSKHSQDFE---TNDELKC----------------KVIGFLEEVMHDPELLT 978

Query: 204  EEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQGPQLLDF---SVDEVAEQLTLIDL 260
            +E   +      R     DP  ++   EE    M +G +   F   S  E+AEQLTL+D 
Sbjct: 979  QER--KAAANIIRTLTQEDPGDNQITLEEITQ-MAEGVKAEPFENHSALEIAEQLTLLDH 1035

Query: 261  ELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQR 320
             +F K+   E  G  W + ++      +P +  T   FN ++  +   ++    + A  R
Sbjct: 1036 LVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHFNDISNLIASEIIRNEDINA--R 1090

Query: 321  AQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIF 380
               +EKW+ +A  CR L N++++  I S++  + I+RLK++W  VS++  +   KL ++ 
Sbjct: 1091 VSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLV 1150

Query: 381  SDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPD 440
            S E    + RE L                        P  VPYLG +LTDL  ++   P+
Sbjct: 1151 SSEGRFKNLREAL--------------------KNCDPPCVPYLGMYLTDLAFIEEGTPN 1190

Query: 441  MLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQS-YRLS 499
              E  L+NF K R    I+  I+Q Q+   +Y +     +   L  Q+ + +E+S Y  S
Sbjct: 1191 YTEDGLVNFSKMRMISHIIREIRQFQQ--TAYKIEHQAKVTQYLLDQSFVMDEESLYESS 1248

Query: 500  RVIEP 504
              IEP
Sbjct: 1249 LRIEP 1253


>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
            1 isoform 1 [Homo sapiens]
          Length = 1273

 Score =  115 bits (288), Expect = 1e-25
 Identities = 97/365 (26%), Positives = 160/365 (43%), Gaps = 53/365 (14%)

Query: 144  VVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQ 203
            V++VL  W+  H QDF     + +L                  K    LE+ + + E   
Sbjct: 954  VLNVLRHWVSKHSQDFE---TNDELKC----------------KVIGFLEEVMHDPELLT 994

Query: 204  EEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQGPQLLDF---SVDEVAEQLTLIDL 260
            +E   +      R     DP  ++   EE    M +G +   F   S  E+AEQLTL+D 
Sbjct: 995  QER--KAAANIIRTLTQEDPGDNQITLEEITQ-MAEGVKAEPFENHSALEIAEQLTLLDH 1051

Query: 261  ELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQR 320
             +F K+   E  G  W + ++      +P +  T   FN ++  +   ++    + A  R
Sbjct: 1052 LVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHFNDISNLIASEIIRNEDINA--R 1106

Query: 321  AQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIF 380
               +EKW+ +A  CR L N++++  I S++  + I+RLK++W  VS++  +   KL ++ 
Sbjct: 1107 VSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLV 1166

Query: 381  SDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPD 440
            S E    + RE L                        P  VPYLG +LTDL  ++   P+
Sbjct: 1167 SSEGRFKNLREAL--------------------KNCDPPCVPYLGMYLTDLAFIEEGTPN 1206

Query: 441  MLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQS-YRLS 499
              E  L+NF K R    I+  I+Q Q+   +Y +     +   L  Q+ + +E+S Y  S
Sbjct: 1207 YTEDGLVNFSKMRMISHIIREIRQFQQ--TAYKIEHQAKVTQYLLDQSFVMDEESLYESS 1264

Query: 500  RVIEP 504
              IEP
Sbjct: 1265 LRIEP 1269


>gi|24797101 Ras protein-specific guanine nucleotide-releasing
           factor 1 isoform 2 [Homo sapiens]
          Length = 489

 Score =  115 bits (288), Expect = 1e-25
 Identities = 97/365 (26%), Positives = 160/365 (43%), Gaps = 53/365 (14%)

Query: 144 VVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQ 203
           V++VL  W+  H QDF     + +L                  K    LE+ + + E   
Sbjct: 170 VLNVLRHWVSKHSQDFE---TNDELKC----------------KVIGFLEEVMHDPELLT 210

Query: 204 EEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQGPQLLDF---SVDEVAEQLTLIDL 260
           +E   +      R     DP  ++   EE    M +G +   F   S  E+AEQLTL+D 
Sbjct: 211 QER--KAAANIIRTLTQEDPGDNQITLEEITQ-MAEGVKAEPFENHSALEIAEQLTLLDH 267

Query: 261 ELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQR 320
            +F K+   E  G  W + ++      +P +  T   FN ++  +   ++    + A  R
Sbjct: 268 LVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHFNDISNLIASEIIRNEDINA--R 322

Query: 321 AQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIF 380
              +EKW+ +A  CR L N++++  I S++  + I+RLK++W  VS++  +   KL ++ 
Sbjct: 323 VSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLV 382

Query: 381 SDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPD 440
           S E    + RE L                        P  VPYLG +LTDL  ++   P+
Sbjct: 383 SSEGRFKNLREAL--------------------KNCDPPCVPYLGMYLTDLAFIEEGTPN 422

Query: 441 MLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQS-YRLS 499
             E  L+NF K R    I+  I+Q Q+   +Y +     +   L  Q+ + +E+S Y  S
Sbjct: 423 YTEDGLVNFSKMRMISHIIREIRQFQQ--TAYKIEHQAKVTQYLLDQSFVMDEESLYESS 480

Query: 500 RVIEP 504
             IEP
Sbjct: 481 LRIEP 485


>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
           sapiens]
          Length = 583

 Score =  111 bits (277), Expect = 3e-24
 Identities = 92/314 (29%), Positives = 155/314 (49%), Gaps = 37/314 (11%)

Query: 243 LLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVT 302
           +L  + +E A Q+TL+D+ +F  ++  E     W+++++  +A   P   A   +FN V+
Sbjct: 45  VLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSA---PNAVAFTRRFNHVS 101

Query: 303 GCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSW 362
             V+  +L A  L    RA+ L  +I+ A++  EL N  +L A++S LQS PI+RL ++W
Sbjct: 102 FWVVREILHAQTLKI--RAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTW 159

Query: 363 GAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVP 422
             +SR+  +TF KL  + S E+N+   R+ +                 SL   P    +P
Sbjct: 160 ALLSRKDKTTFEKLEYVMSKEDNYKRLRDYI----------------SSLKMTP---CIP 200

Query: 423 YLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEW-EILARIQQLQRRCQSYTLSPHPPIL 481
           YLG +L+DL  +D+A P    G ++  E+R      IL  I  LQ+ C+ Y +   P + 
Sbjct: 201 YLGIYLSDLTYIDSAYPS--TGSILENEQRSNLMNNILRIISDLQQSCE-YDIPMLPHVQ 257

Query: 482 AALHA------QNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSS 535
             L++        +  E+ +Y+LS  IE P  S P S   R  +   +  ++  +  KS 
Sbjct: 258 KYLNSVQYIEELQKFVEDDNYKLSLKIE-PGTSTPRSAASREDLVGPEVGASPQSGRKSV 316

Query: 536 SPSGS--PGDPSSP 547
           +  G+  P  P SP
Sbjct: 317 AAEGALLPQTPPSP 330


>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
          Length = 1333

 Score =  105 bits (262), Expect = 1e-22
 Identities = 142/598 (23%), Positives = 233/598 (38%), Gaps = 106/598 (17%)

Query: 66   VRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPPPPPGV 125
            + +++A  + +L+  L +     DP+F+  FL TYR+F     LL  ++     P P   
Sbjct: 598  IPIIKAGTVIKLIERLTY-HMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPT 656

Query: 126  EIKKTAVQ--DLSFNKNLRA------------VVSVLGSWLQDHPQDF-RDPPAHSDLGS 170
            E  + A++  D   +  L+             V++V   W++ H  DF RD      L  
Sbjct: 657  EADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYL---LQR 713

Query: 171  VRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQEEEPPQVWT---GPPRVA-QTSDPDSS 226
            +  F+G    G A  +  E + +  ++  +  ++  P    T    PP V    S P   
Sbjct: 714  MEEFIG-TVRGKAMKKWVESITK-IIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHI 771

Query: 227  EACAEEEEGLMPQGPQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAG 286
            E               LL     E+A QLTL++ +L+  V+  E +GSVW++ D+     
Sbjct: 772  ETF------------DLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDK---EI 816

Query: 287  ASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAI 346
             SP +   +     +T      ++    L   +R   + + I I Q  +EL NF+ +  +
Sbjct: 817  NSPNLLKMIRHTTNLTLWFEKCIVETENL--EERVAVVSRIIEILQVFQELNNFNGVLEV 874

Query: 347  LSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEE- 405
            +SA+ S+P+YRL  ++                        + SR+    EEA E S++  
Sbjct: 875  VSAMNSSPVYRLDHTF----------------------EQIPSRQKKILEEAHELSEDHY 912

Query: 406  DNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLE---GDLINFEKRRKEWEILARI 462
                  L S  PP  VP+ G +LT+++  +   P++L+    +LINF KRRK  EI   I
Sbjct: 913  KKYLAKLRSINPP-CVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEI 971

Query: 463  QQLQRRCQSYTLSPHPPILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLT 522
            QQ Q   Q Y L     I       N +        +  +              + + + 
Sbjct: 972  QQYQN--QPYCLRVESDIKRFFENLNPMGNSMEKEFTDYL------------FNKSLEIE 1017

Query: 523  KRLSAKLAR--EKSSSPSGSPG-DPSSPTSSLCISPSVSPGSPPSSPRSRDAPAGSPPAS 579
             R    L R  +K S P  SPG  PS+P       P+     P     SR   + +   +
Sbjct: 1018 PRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTA 1077

Query: 580  PGPQGPSTKLPLSLDLPSPRPFALPLGSPRIPLPAQQSSEARVIRVSIDNDHGNLYRS 637
              P  P T                    P  P PA  +S    +    D+DH + + S
Sbjct: 1078 SAPNSPRT--------------------PLTPPPASGASSTTDVCSVFDSDHSSPFHS 1115



 Score = 31.6 bits (70), Expect = 2.7
 Identities = 56/252 (22%), Positives = 87/252 (34%), Gaps = 49/252 (19%)

Query: 396  EEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKE 455
            E  TE +    N+P + P  PPP       T +  +   D + P     D +  +     
Sbjct: 1070 ESETESTASAPNSPRT-PLTPPPASGASSTTDVCSVFDSDHSSPFHSSNDTVFIQVTLPH 1128

Query: 456  WEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQSYRL-SRVIEPPAASCPSSPR 514
                A +  +     +  +   PP+      ++   E    ++ S+ ++ P A  P  P 
Sbjct: 1129 GPRSASVSSISLTKGTDEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPT 1188

Query: 515  IRR---RISLTKRLSAKLAREKSSSPSGSPGDPSSPTSSLCISPSVSPGSP--------- 562
             +    R S++ R S        S P  SP  P  P      +P V   SP         
Sbjct: 1189 SKAYSPRYSISDRTSI-------SDPPESP--PLLPPREPVRTPDVFSSSPLHLQPPPLG 1239

Query: 563  ----------PSSPRSRDAPAGSPPASPGPQG-----PSTKLPLSLDLPSPRPFALPLGS 607
                      P+SP     P   PP +P P G     PS  L   +DL S       +  
Sbjct: 1240 KKSDHGNAFFPNSPSPFTPP---PPQTPSPHGTRRHLPSPPLTQEVDLHS-------IAG 1289

Query: 608  PRIPLPAQQSSE 619
            P +P P Q +S+
Sbjct: 1290 PPVP-PRQSTSQ 1300


>gi|154689780 son of sevenless homolog 2 [Homo sapiens]
          Length = 1332

 Score =  104 bits (260), Expect = 2e-22
 Identities = 140/568 (24%), Positives = 225/568 (39%), Gaps = 91/568 (16%)

Query: 64   SKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPPPPP 123
            S + +++   + +L+  L +     DP+F+  FL TYR+F     LL  L+     P P 
Sbjct: 594  SGIPIIKGGTVVKLIERLTY-HMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPE 652

Query: 124  GVEIKKTAVQ--------DLS-FNKNL-----RAVVSVLGSWLQDHPQDFRDPPAHSDLG 169
              +  K A++        DL  F K         +++V   W++ H  DF       DL 
Sbjct: 653  PTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFE-----RDLE 707

Query: 170  SVRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQE------------EEPPQVWTGPPRV 217
             +     + +    +A K  K +E   +   R+++            E PP     PP  
Sbjct: 708  LLERLESFISSVRGKAMK--KWVESIAKIIRRKKQAQANGVSHNITFESPP-----PPIE 760

Query: 218  AQTSDPDSSEACAEEEEGLMPQGPQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWS 277
               S P   E               L+     E+A QLTL++ +L+ KV+  E +GSVW+
Sbjct: 761  WHISKPGQFETF------------DLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWT 808

Query: 278  QRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCREL 337
            + D+      SP +   +     +T      ++ A      +R   L + I I Q  ++L
Sbjct: 809  KEDK---EINSPNLLKMIRHTTNLTLWFEKCIVEAENF--EERVAVLSRIIEILQVFQDL 863

Query: 338  RNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEE 397
             NF+ +  I+SA+ S  +YRL  ++ A+                        R+IL  +E
Sbjct: 864  NNFNGVLEIVSAVNSVSVYRLDHTFEALQER--------------------KRKIL--DE 901

Query: 398  ATEGSQEE-DNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLE---GDLINFEKRR 453
            A E SQ+        L S  PP  VP+ G +LT+++  +    D L+    DLINF KRR
Sbjct: 902  AVELSQDHFKKYLVKLKSINPP-CVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRR 960

Query: 454  KEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQL-----TEEQSYRLSRVIEPPAAS 508
            K  EI   IQQ Q   Q Y L   P +       N +      E   Y  ++ +E    +
Sbjct: 961  KVAEITGEIQQYQN--QPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRN 1018

Query: 509  CPSSPRIRRRISLT-KRLSAKLAREKSSSPSGSPGDPSSPTSSLCISPSVSPGSPPSSPR 567
            C   PR  R+ + + K    +    +  S SG+     +P        S S  +      
Sbjct: 1019 CKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELES 1078

Query: 568  SRDAPAGSPPASPGPQGPSTKLPLSLDL 595
            +  AP      S  P   S+ L + LD+
Sbjct: 1079 TVSAPTSPNTPSTPPVSASSDLSVFLDV 1106


>gi|7662334 RAS guanyl releasing protein 3 (calcium and
           DAG-regulated) isoform 2 [Homo sapiens]
          Length = 689

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 68/266 (25%), Positives = 124/266 (46%), Gaps = 31/266 (11%)

Query: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309
           E+AE LT ++ + F ++   +    V       G    +PT+  ++A FN ++  V   V
Sbjct: 155 ELAEHLTFLEHKSFRRISFTDYQSYVIH-----GCLENNPTLERSIALFNGISKWVQLMV 209

Query: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369
           L  P     QRA+ + K+I +A++  +L+NF++L A++  L  + I RLK +   +S E 
Sbjct: 210 LSKP--TPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEV 267

Query: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429
              + +++++ S   N+ + R+     +  +                    +P LG  L 
Sbjct: 268 TKNWNEMTELVSSNGNYCNYRKAFADCDGFK--------------------IPILGVHLK 307

Query: 430 DLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQ 489
           DL+ +    PD  E + +N  K  +    L+ +  LQ    S+ L P+  ++  L     
Sbjct: 308 DLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQN--ASHHLEPNMDLINLLTLSLD 365

Query: 490 L--TEEQSYRLSRVIEPPAASCPSSP 513
           L  TE+  Y+LS V+EP  +  P+SP
Sbjct: 366 LYHTEDDIYKLSLVLEPRNSKSPTSP 391


>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
            sapiens]
          Length = 1095

 Score = 86.3 bits (212), Expect = 9e-17
 Identities = 82/282 (29%), Positives = 129/282 (45%), Gaps = 41/282 (14%)

Query: 229  CAEEEEGLMPQGPQ-----LLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPG 283
            CA   + L  +G       L DF   E+AEQLTL+D ELF K+ + E L  +W++     
Sbjct: 835  CATSSQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVL--LWAKEQNEE 892

Query: 284  AAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSL 343
                SP +      FN ++  V   ++      A  R + L K+I+I +  R+L NF+S 
Sbjct: 893  K---SPNLTQFTEHFNNMSYWVRSIIMLQE--KAQDRERLLLKFIKIMKHLRKLNNFNSY 947

Query: 344  RAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQ 403
             AILSAL S PI RL+  W   + E L+ +     +    ++  + R  L + E      
Sbjct: 948  LAILSALDSAPIRRLE--WQKQTSEGLAEY---CTLIDSSSSFRAYRAALSEVE------ 996

Query: 404  EEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQ 463
                          P  +PYLG  L DL  +    PD ++G  +NF KR +++ IL  ++
Sbjct: 997  --------------PPCIPYLGLILQDLTFVHLGNPDYIDGK-VNFSKRWQQFNILDSMR 1041

Query: 464  QLQRRCQSYTLSPHPPILAALH-AQNQLTEEQSYRLSRVIEP 504
              Q+    Y +  +  I+   +   + L EE  + LS  I+P
Sbjct: 1042 CFQQ--AHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKP 1081


>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
            sapiens]
          Length = 1077

 Score = 86.3 bits (212), Expect = 9e-17
 Identities = 82/282 (29%), Positives = 129/282 (45%), Gaps = 41/282 (14%)

Query: 229  CAEEEEGLMPQGPQ-----LLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPG 283
            CA   + L  +G       L DF   E+AEQLTL+D ELF K+ + E L  +W++     
Sbjct: 817  CATSSQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVL--LWAKEQNEE 874

Query: 284  AAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSL 343
                SP +      FN ++  V   ++      A  R + L K+I+I +  R+L NF+S 
Sbjct: 875  K---SPNLTQFTEHFNNMSYWVRSIIMLQE--KAQDRERLLLKFIKIMKHLRKLNNFNSY 929

Query: 344  RAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQ 403
             AILSAL S PI RL+  W   + E L+ +     +    ++  + R  L + E      
Sbjct: 930  LAILSALDSAPIRRLE--WQKQTSEGLAEY---CTLIDSSSSFRAYRAALSEVE------ 978

Query: 404  EEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQ 463
                          P  +PYLG  L DL  +    PD ++G  +NF KR +++ IL  ++
Sbjct: 979  --------------PPCIPYLGLILQDLTFVHLGNPDYIDGK-VNFSKRWQQFNILDSMR 1023

Query: 464  QLQRRCQSYTLSPHPPILAALH-AQNQLTEEQSYRLSRVIEP 504
              Q+    Y +  +  I+   +   + L EE  + LS  I+P
Sbjct: 1024 CFQQ--AHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKP 1063


>gi|213385270 RAS guanyl releasing protein 3 (calcium and
           DAG-regulated) isoform 1 [Homo sapiens]
          Length = 690

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 69/267 (25%), Positives = 125/267 (46%), Gaps = 32/267 (11%)

Query: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309
           E+AE LT ++ + F ++   +    V       G    +PT+  ++A FN ++  V   V
Sbjct: 155 ELAEHLTFLEHKSFRRISFTDYQSYVIH-----GCLENNPTLERSIALFNGISKWVQLMV 209

Query: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369
           L  P     QRA+ + K+I +A++  +L+NF++L A++  L  + I RLK +   +S E 
Sbjct: 210 LSKP--TPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEV 267

Query: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429
              + +++++ S   N+ + R+     +  +                    +P LG  L 
Sbjct: 268 TKNWNEMTELVSSNGNYCNYRKAFADCDGFK--------------------IPILGVHLK 307

Query: 430 DLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQ 489
           DL+ +    PD  E + +N  K  +    L+ +  LQ    S+ L P+  ++  L     
Sbjct: 308 DLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQN--ASHHLEPNMDLINLLTLSLD 365

Query: 490 L--TEEQSYRLSRVIEP-PAASCPSSP 513
           L  TE+  Y+LS V+EP  + S P+SP
Sbjct: 366 LYHTEDDIYKLSLVLEPRNSKSQPTSP 392


>gi|24762239 RAS guanyl releasing protein 3 (calcium and
           DAG-regulated) isoform 1 [Homo sapiens]
          Length = 690

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 69/267 (25%), Positives = 125/267 (46%), Gaps = 32/267 (11%)

Query: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309
           E+AE LT ++ + F ++   +    V       G    +PT+  ++A FN ++  V   V
Sbjct: 155 ELAEHLTFLEHKSFRRISFTDYQSYVIH-----GCLENNPTLERSIALFNGISKWVQLMV 209

Query: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369
           L  P     QRA+ + K+I +A++  +L+NF++L A++  L  + I RLK +   +S E 
Sbjct: 210 LSKP--TPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEV 267

Query: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429
              + +++++ S   N+ + R+     +  +                    +P LG  L 
Sbjct: 268 TKNWNEMTELVSSNGNYCNYRKAFADCDGFK--------------------IPILGVHLK 307

Query: 430 DLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQ 489
           DL+ +    PD  E + +N  K  +    L+ +  LQ    S+ L P+  ++  L     
Sbjct: 308 DLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQN--ASHHLEPNMDLINLLTLSLD 365

Query: 490 L--TEEQSYRLSRVIEP-PAASCPSSP 513
           L  TE+  Y+LS V+EP  + S P+SP
Sbjct: 366 LYHTEDDIYKLSLVLEPRNSKSQPTSP 392


>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
          Length = 609

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 71/266 (26%), Positives = 120/266 (45%), Gaps = 29/266 (10%)

Query: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309
           E+AE LT ++   F K+   +    V       G    +P +   ++ FN+V+  V   +
Sbjct: 157 ELAEHLTYLEYRSFCKILFQDYHSFVTH-----GCTVDNPVLERFISLFNSVSQWVQLMI 211

Query: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369
           L  P   APQRA  +  ++ +A++  +L+NF++L A++  L  + I RLK +   VS E 
Sbjct: 212 LSKP--TAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPET 269

Query: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429
           +  +  L+++ +   N+ + R  L    A  G +                  P LG  L 
Sbjct: 270 IKLWEGLTELVTATGNYGNYRRRL---AACVGFR-----------------FPILGVHLK 309

Query: 430 DLVMLDTALPDMLE--GDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQ 487
           DLV L  ALPD L+     +N  K ++ + IL  +  +         +P    L  +   
Sbjct: 310 DLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLD 369

Query: 488 NQLTEEQSYRLSRVIEPPAASCPSSP 513
              TE++ Y+LS   EP + S P+SP
Sbjct: 370 QYQTEDELYQLSLQREPRSKSSPTSP 395


>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
          Length = 609

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 71/266 (26%), Positives = 120/266 (45%), Gaps = 29/266 (10%)

Query: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309
           E+AE LT ++   F K+   +    V       G    +P +   ++ FN+V+  V   +
Sbjct: 157 ELAEHLTYLEYRSFCKILFQDYHSFVTH-----GCTVDNPVLERFISLFNSVSQWVQLMI 211

Query: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369
           L  P   APQRA  +  ++ +A++  +L+NF++L A++  L  + I RLK +   VS E 
Sbjct: 212 LSKP--TAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPET 269

Query: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429
           +  +  L+++ +   N+ + R  L    A  G +                  P LG  L 
Sbjct: 270 IKLWEGLTELVTATGNYGNYRRRL---AACVGFR-----------------FPILGVHLK 309

Query: 430 DLVMLDTALPDMLE--GDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQ 487
           DLV L  ALPD L+     +N  K ++ + IL  +  +         +P    L  +   
Sbjct: 310 DLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLD 369

Query: 488 NQLTEEQSYRLSRVIEPPAASCPSSP 513
              TE++ Y+LS   EP + S P+SP
Sbjct: 370 QYQTEDELYQLSLQREPRSKSSPTSP 395


>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
          Length = 609

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 71/266 (26%), Positives = 120/266 (45%), Gaps = 29/266 (10%)

Query: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309
           E+AE LT ++   F K+   +    V       G    +P +   ++ FN+V+  V   +
Sbjct: 157 ELAEHLTYLEYRSFCKILFQDYHSFVTH-----GCTVDNPVLERFISLFNSVSQWVQLMI 211

Query: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369
           L  P   APQRA  +  ++ +A++  +L+NF++L A++  L  + I RLK +   VS E 
Sbjct: 212 LSKP--TAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPET 269

Query: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429
           +  +  L+++ +   N+ + R  L    A  G +                  P LG  L 
Sbjct: 270 IKLWEGLTELVTATGNYGNYRRRL---AACVGFR-----------------FPILGVHLK 309

Query: 430 DLVMLDTALPDMLE--GDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQ 487
           DLV L  ALPD L+     +N  K ++ + IL  +  +         +P    L  +   
Sbjct: 310 DLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLD 369

Query: 488 NQLTEEQSYRLSRVIEPPAASCPSSP 513
              TE++ Y+LS   EP + S P+SP
Sbjct: 370 QYQTEDELYQLSLQREPRSKSSPTSP 395


>gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]
          Length = 673

 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 71/263 (26%), Positives = 110/263 (41%), Gaps = 30/263 (11%)

Query: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309
           E+A+ LT ++   F  +   +    V       G+    P +  +V   N+V+  V   V
Sbjct: 204 ELAQHLTYLEFRSFQAITPQDLRSYVLQ-----GSVRGCPALEGSVGLSNSVSRWVQVMV 258

Query: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369
           L  PG    QRAQ L+K+I +AQR  +L+NF++L A+   L  + I RLK S   +S + 
Sbjct: 259 LSRPGPL--QRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDS 316

Query: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429
                +L+++ +  NN+   R          G +                 +P LG  L 
Sbjct: 317 TKALLELTELLASHNNYARYRRTW---AGCAGFR-----------------LPVLGVHLK 356

Query: 430 DLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQ 489
           DLV L  A PD L    ++  K    +  L  +  LQ +    + +     L  L     
Sbjct: 357 DLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLF 416

Query: 490 LTEEQSYRLSRVIEPPAASCPSS 512
            TE++ Y LS   EP    CP S
Sbjct: 417 YTEDEIYELSYAREP---RCPKS 436


>gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo
           sapiens]
          Length = 659

 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 71/263 (26%), Positives = 110/263 (41%), Gaps = 30/263 (11%)

Query: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309
           E+A+ LT ++   F  +   +    V       G+    P +  +V   N+V+  V   V
Sbjct: 190 ELAQHLTYLEFRSFQAITPQDLRSYVLQ-----GSVRGCPALEGSVGLSNSVSRWVQVMV 244

Query: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369
           L  PG    QRAQ L+K+I +AQR  +L+NF++L A+   L  + I RLK S   +S + 
Sbjct: 245 LSRPGPL--QRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDS 302

Query: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429
                +L+++ +  NN+   R          G +                 +P LG  L 
Sbjct: 303 TKALLELTELLASHNNYARYRRTW---AGCAGFR-----------------LPVLGVHLK 342

Query: 430 DLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQ 489
           DLV L  A PD L    ++  K    +  L  +  LQ +    + +     L  L     
Sbjct: 343 DLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLF 402

Query: 490 LTEEQSYRLSRVIEPPAASCPSS 512
            TE++ Y LS   EP    CP S
Sbjct: 403 YTEDEIYELSYAREP---RCPKS 422


>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
           sapiens]
          Length = 762

 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 66/264 (25%), Positives = 115/264 (43%), Gaps = 29/264 (10%)

Query: 249 DEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGS 308
           +E++E LT ++ + F ++   +    + +          +PT+  ++A  N ++  V   
Sbjct: 207 EELSEHLTYLEFKSFRRISFSDYQNYLVNS-----CVKENPTMERSIALCNGISQWVQLM 261

Query: 309 VLGAPGLAAPQ-RAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSR 367
           VL  P    PQ RA+   K+I++AQ+  +L+NF++L A++  L  + I RLK +   V  
Sbjct: 262 VLSRP---TPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318

Query: 368 EPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTF 427
           E      +++++ S   N+ + R      E T+                    +P LG  
Sbjct: 319 EINKVLGEMTELLSSSRNYDNYRRA--YGECTDFK------------------IPILGVH 358

Query: 428 LTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQ 487
           L DL+ L  A+PD LE   +N  K    +  ++ + QLQ        +     L  L   
Sbjct: 359 LKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLD 418

Query: 488 NQLTEEQSYRLSRVIEPPAASCPS 511
              TE++ Y LS   EP     PS
Sbjct: 419 LYYTEDEIYELSYAREPRNHRAPS 442


>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
           sapiens]
          Length = 797

 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 64/257 (24%), Positives = 113/257 (43%), Gaps = 29/257 (11%)

Query: 249 DEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGS 308
           +E++E LT ++ + F ++   +    + +          +PT+  ++A  N ++  V   
Sbjct: 207 EELSEHLTYLEFKSFRRISFSDYQNYLVNS-----CVKENPTMERSIALCNGISQWVQLM 261

Query: 309 VLGAPGLAAPQ-RAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSR 367
           VL  P    PQ RA+   K+I++AQ+  +L+NF++L A++  L  + I RLK +   V  
Sbjct: 262 VLSRP---TPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318

Query: 368 EPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTF 427
           E      +++++ S   N+ + R      E T+                    +P LG  
Sbjct: 319 EINKVLGEMTELLSSSRNYDNYRRA--YGECTDFK------------------IPILGVH 358

Query: 428 LTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQ 487
           L DL+ L  A+PD LE   +N  K    +  ++ + QLQ        +     L  L   
Sbjct: 359 LKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLD 418

Query: 488 NQLTEEQSYRLSRVIEP 504
              TE++ Y LS   EP
Sbjct: 419 LYYTEDEIYELSYAREP 435


>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
          Length = 1499

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 89/385 (23%), Positives = 151/385 (39%), Gaps = 40/385 (10%)

Query: 224  DSSEACAEEE--EGLMPQGPQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDR 281
            ++   C++E+  E L      LL  S  EVA QL++ + ELF  +   E +  ++  R +
Sbjct: 692  ETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSK 751

Query: 282  PGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFS 341
               A     ++      N  T  V   +L        +R + ++ +I+IA  CRE +NF+
Sbjct: 752  TSCAN----LKRFEEVINQETFWVASEILRETNQL--KRMKIIKHFIKIALHCRECKNFN 805

Query: 342  SLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEG 401
            S+ AI+S L   P+ RL+ +W  +  +    F+ L  +F    N    R +L  +     
Sbjct: 806  SMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNL--- 862

Query: 402  SQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILAR 461
                            P  +P       DL  L       ++G L+NFEK R    ++A+
Sbjct: 863  ---------------QPPIIPLFPVIKKDLTFLHEGNDSKVDG-LVNFEKLR----MIAK 902

Query: 462  IQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISL 521
              +   R  S  + P             L        +  +   A +     R+RR   L
Sbjct: 903  EIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSSFL 962

Query: 522  -TKRL--SAKLAREKSSSPSG---SPGDPSSPTSSLCISPSVSPGSPPSSPRSRDAPAGS 575
              K+L   A++AR+     S       + S  T SL   P+ +  + P +P  +  P  S
Sbjct: 963  NAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATN--TLPKNPGDK-KPVKS 1019

Query: 576  PPASPGPQGPSTKLPLSLDLPSPRP 600
              +   P+  S +   SL  P  +P
Sbjct: 1020 ETSPVAPRAGSQQKAQSLPQPQQQP 1044



 Score = 33.9 bits (76), Expect = 0.54
 Identities = 30/102 (29%), Positives = 41/102 (40%), Gaps = 17/102 (16%)

Query: 63  TSKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPPPP 122
           T K  ++     ERL   LV      DP+F+  FL TYRT         FL  PM     
Sbjct: 265 TRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRT---------FLSSPM----- 310

Query: 123 PGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPA 164
              E+ K  ++  +       V  V+  W+ +H  DF   PA
Sbjct: 311 ---EVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPA 349


>gi|40255197 RasGEF domain family, member 1C [Homo sapiens]
          Length = 466

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 92/419 (21%), Positives = 167/419 (39%), Gaps = 52/419 (12%)

Query: 41  PAEGPGGSQAPSPIANTFLHYRTSKVRVLRAARLERLVGELV-FGDREQDPSFMPAFLAT 99
           P E   G QA  P+ +              +A LE L+  LV   D   + +++  FL +
Sbjct: 20  PTEPTDGEQAGQPLLDG----------APSSASLETLIQHLVPTADYYPEKAYIFTFLLS 69

Query: 100 YRTFVPTACLLGFLLPPMPPPPPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDF 159
            R F+    LL  +            ++ K  +      K    ++ +L  W +  P+DF
Sbjct: 70  SRLFIEPRELLARVCHLCIEQQ----QLDKPVLDKARVRKFGPKLLQLLAEWTETFPRDF 125

Query: 160 RDPPAHSDLGSVRTFLGWAAP-GSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVA 218
           ++    S +G ++  +G  AP   A  ++  +LL+   ++    ++     V    P   
Sbjct: 126 QE---ESTIGHLKDVVGRIAPCDEAYRKRMHQLLQALHQKLAALRQGPEGLVGADKPISY 182

Query: 219 QTSDPDSSEACAEEEEGLMPQGPQLLDFSVDE--VAEQLTLIDLELFSKVRLYECLGSVW 276
           +T  P S                +LL    D   +A+QLT ++LE    +   E + +  
Sbjct: 183 RTKPPASIHR-------------ELLGVCSDPYTLAQQLTHVELERLRHIGPEEFVQAFV 229

Query: 277 SQ----RDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQ 332
           ++      +P  +  +  + A V  FN +  C L +          QRAQ +E +I +A+
Sbjct: 230 NKDPLASTKPCFSDKTSNLEAYVKWFNRL--CYLVATEICMPAKKKQRAQVIEFFIDVAR 287

Query: 333 RCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREI 392
            C  + NF+SL AI+S +  +P+ RLK++W  V         + ++ F  E+    +   
Sbjct: 288 ECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV---------RTAKFFILEHQMDPTGNF 338

Query: 393 LFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEK 451
                A  G+     T  S   K     +P+    + D+  L+    + L    +NFEK
Sbjct: 339 CNYRTALRGAAHRSLTAHSSREKI---VIPFFSLLIKDIYFLNEGCANRLPNGHVNFEK 394


>gi|117168263 RasGEF domain family, member 1A [Homo sapiens]
          Length = 481

 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 102/416 (24%), Positives = 175/416 (42%), Gaps = 61/416 (14%)

Query: 69  LRAARLERLVGELV-FGDREQDPSFMPAFLATYRTFVPTACLL---GFLLPPMPPPPPPG 124
           L +  LE L+  LV   D   D +++  FL + R F+P   LL   G +          G
Sbjct: 45  LISGSLEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAG 104

Query: 125 VEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAE 184
            E  K      SF+     +V +L  W +  P DF+D  A ++L ++   +      +  
Sbjct: 105 PEKAKLK----SFSAK---IVQLLKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGT 157

Query: 185 AQKAEKLLED--FLEEAEREQEEE------PPQVWTGPPRVAQTSDPDSSEACAEEEEGL 236
            +KA   +     L  A R Q +E      PP V  GP  + +T  P + +         
Sbjct: 158 VKKAIAQMTQSLLLSLAARSQLQELREKLRPPAVDKGP--ILKTKPPAAQK--------- 206

Query: 237 MPQGPQLLDFSVDEV--AEQLTLIDLELFSKV------RLYECLGSVWSQRDRPGAAGAS 288
                 +L    D +  A+QLT I+L+  S +      ++   + S+ + R R G    +
Sbjct: 207 -----DILGVCCDPLVLAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCR-GDLTKT 260

Query: 289 PTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILS 348
            ++ A    FN ++  V   V     +    R + LE +I +A+ C  + NF+S+ AI+S
Sbjct: 261 YSLEAYDNWFNCLSMLVATEVCRV--VKKKHRTRMLEFFIDVARECFNIGNFNSMMAIIS 318

Query: 349 ALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNT 408
            +  +P+ RLK++W   S+   + F  L       +N  + R  L  + AT+ SQ  +++
Sbjct: 319 GMNLSPVARLKKTW---SKVKTAKFDVLEHHMDPSSNFCNYRTAL--QGATQRSQMANSS 373

Query: 409 PGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQ 464
              +        +P    F+ D+  L     + L    INF   +K WEI  +I +
Sbjct: 374 REKI-------VIPVFNLFVKDIYFLHKIHTNHLPNGHINF---KKFWEISRQIHE 419


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.132    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,284,471
Number of Sequences: 37866
Number of extensions: 2124365
Number of successful extensions: 29944
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 268
Number of HSP's successfully gapped in prelim test: 1189
Number of HSP's that attempted gapping in prelim test: 19091
Number of HSP's gapped (non-prelim): 10021
length of query: 716
length of database: 18,247,518
effective HSP length: 109
effective length of query: 607
effective length of database: 14,120,124
effective search space: 8570915268
effective search space used: 8570915268
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.