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Search of human proteins with 239582763
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239582763 ral guanine nucleotide dissociation
stimulator-like 3 isoform 2 [Homo sapiens]
(710 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239582763 ral guanine nucleotide dissociation stimulator-like... 1419 0.0
gi|239582765 ral guanine nucleotide dissociation stimulator-like... 1413 0.0
gi|93102367 ral guanine nucleotide dissociation stimulator-like ... 447 e-125
gi|4758532 ral guanine nucleotide dissociation stimulator-like 2... 384 e-106
gi|24307909 ral guanine nucleotide dissociation stimulator isofo... 381 e-105
gi|108796058 ral guanine nucleotide dissociation stimulator isof... 381 e-105
gi|23957680 ral guanine nucleotide dissociation stimulator-like ... 180 5e-45
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ... 125 1e-28
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 120 3e-27
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 115 1e-25
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 115 1e-25
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 115 1e-25
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo... 112 9e-25
gi|154689780 son of sevenless homolog 2 [Homo sapiens] 104 2e-22
gi|15529996 son of sevenless homolog 1 [Homo sapiens] 103 6e-22
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 89 1e-17
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 86 9e-17
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 86 9e-17
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 86 2e-16
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 86 2e-16
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens] 82 2e-15
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens] 82 2e-15
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens] 82 2e-15
gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens] 74 4e-13
gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapi... 74 4e-13
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 74 4e-13
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 73 1e-12
gi|40255197 RasGEF domain family, member 1C [Homo sapiens] 69 2e-11
gi|117168263 RasGEF domain family, member 1A [Homo sapiens] 68 3e-11
gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1 [... 68 3e-11
>gi|239582763 ral guanine nucleotide dissociation stimulator-like 3
isoform 2 [Homo sapiens]
Length = 710
Score = 1419 bits (3674), Expect = 0.0
Identities = 710/710 (100%), Positives = 710/710 (100%)
Query: 1 MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLH 60
MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLH
Sbjct: 1 MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLH 60
Query: 61 YRTSKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPP 120
YRTSKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPP
Sbjct: 61 YRTSKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPP 120
Query: 121 PPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAP 180
PPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAP
Sbjct: 121 PPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAP 180
Query: 181 GSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQG 240
GSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQG
Sbjct: 181 GSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQG 240
Query: 241 PQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNT 300
PQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNT
Sbjct: 241 PQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNT 300
Query: 301 VTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKR 360
VTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKR
Sbjct: 301 VTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKR 360
Query: 361 SWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGP 420
SWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGP
Sbjct: 361 SWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGP 420
Query: 421 VPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPI 480
VPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPI
Sbjct: 421 VPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPI 480
Query: 481 LAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGS 540
LAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGS
Sbjct: 481 LAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGS 540
Query: 541 PGDPSSPTSSVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRPFALPLG 600
PGDPSSPTSSVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRPFALPLG
Sbjct: 541 PGDPSSPTSSVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRPFALPLG 600
Query: 601 SPRIPLPAQQSSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACD 660
SPRIPLPAQQSSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACD
Sbjct: 601 SPRIPLPAQQSSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACD 660
Query: 661 YQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS 710
YQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS
Sbjct: 661 YQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS 710
>gi|239582765 ral guanine nucleotide dissociation stimulator-like 3
isoform 1 [Homo sapiens]
Length = 716
Score = 1413 bits (3657), Expect = 0.0
Identities = 710/716 (99%), Positives = 710/716 (99%), Gaps = 6/716 (0%)
Query: 1 MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLH 60
MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLH
Sbjct: 1 MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLH 60
Query: 61 YRTSKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPP 120
YRTSKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPP
Sbjct: 61 YRTSKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPP 120
Query: 121 PPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAP 180
PPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAP
Sbjct: 121 PPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAP 180
Query: 181 GSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQG 240
GSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQG
Sbjct: 181 GSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQG 240
Query: 241 PQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNT 300
PQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNT
Sbjct: 241 PQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNT 300
Query: 301 VTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKR 360
VTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKR
Sbjct: 301 VTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKR 360
Query: 361 SWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGP 420
SWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGP
Sbjct: 361 SWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGP 420
Query: 421 VPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPI 480
VPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPI
Sbjct: 421 VPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPI 480
Query: 481 LAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGS 540
LAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGS
Sbjct: 481 LAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGS 540
Query: 541 PGDPSSPTS------SVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRP 594
PGDPSSPTS SVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRP
Sbjct: 541 PGDPSSPTSSLCISPSVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRP 600
Query: 595 FALPLGSPRIPLPAQQSSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVP 654
FALPLGSPRIPLPAQQSSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVP
Sbjct: 601 FALPLGSPRIPLPAQQSSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVP 660
Query: 655 QPWACDYQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS 710
QPWACDYQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS
Sbjct: 661 QPWACDYQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS 716
>gi|93102367 ral guanine nucleotide dissociation stimulator-like 1
[Homo sapiens]
Length = 803
Score = 447 bits (1149), Expect = e-125
Identities = 292/741 (39%), Positives = 408/741 (55%), Gaps = 75/741 (10%)
Query: 14 LQDWGEETEDGAVYSVSLRRQRSQRRSPAE----GPGGSQAPSPIANTFLHYRTSKVRVL 69
+QDWGEE E+GAVY V+L+R + Q+ + G G Q P +T Y T K+R +
Sbjct: 47 IQDWGEEVEEGAVYHVTLKRVQIQQAANKGARWLGVEGDQLPP--GHTVSQYETCKIRTI 104
Query: 70 RAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPPPPPGVEIKK 129
+A LE+LV L+ + D +++ FL+TYR F T +L LL P E
Sbjct: 105 KAGTLEKLVENLLTAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTSPNCEEDG 164
Query: 130 TAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAEAQKAE 189
+ S A+ S+L +WL +DFR+PP L + +L PGS ++A+
Sbjct: 165 SQSSSESKMVIRNAIASILRAWLDQCAEDFREPPHFPCLQKLLDYLTRMMPGSDPERRAQ 224
Query: 190 KLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQGPQLLDFSVD 249
LLE F ++QE E G P S EEEE + + FS D
Sbjct: 225 NLLEQF-----QKQEVETDN---GLPNTISFS-------LEEEEELEGGESAEFTCFSED 269
Query: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309
VAEQLT +D +LF KV + CLG +WS+RD+ +PT+RAT++QFNT+T CV+ ++
Sbjct: 270 LVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVVSTI 329
Query: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369
LG L QRA+ +EKWI IA CR L+NFSSLRAI+SALQSN IYRLK++W AV R+
Sbjct: 330 LGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVPRDR 389
Query: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGS-------QEEDNTPGSLPSKPP----P 418
+ F +LS IFSD NNHL+SRE+L +E ++ + + + T L +
Sbjct: 390 MLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMGVMQ 449
Query: 419 GPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHP 478
G VPYLGTFLTDL MLDTAL D +EG LINFEKRR+E+E++A+I+ LQ C SY ++P
Sbjct: 450 GTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQSACNSYCMTPDQ 509
Query: 479 PILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAK-LAREKSSSP 537
+ Q LTEE+SY LS IE A + +SP+ R+ S+ KRLS L + +SP
Sbjct: 510 KFIQWFQRQQLLTEEESYALSCEIEAAADASTTSPKPRK--SMVKRLSLLFLGSDMITSP 567
Query: 538 SGSPGDPSSPTSSVSPGSPPS------SPRSRDAPAGSPPASPGPQGPSTKLP------- 584
+ + P S S S S S +A GS P P KL
Sbjct: 568 TPTKEQPKSTASGSSGESMDSVSVSSCESNHSEAEEGSITPMDTPDEPQKKLSESSSSCS 627
Query: 585 --LSLDLPSPRPFAL--PLGSPRI-----------------------PLPAQQSSEARVI 617
S+D S +L PL SP P+ QQ+ + +I
Sbjct: 628 SIHSMDTNSSGMSSLINPLSSPPSCNNNPKIHKRSVSVTSITSTVLPPVYNQQNEDTCII 687
Query: 618 RVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGDRVLLIPD 677
R+S+++++GN+Y+SI+LTSQDK P+V++RA+ KHN+ A +Y+L QV+ D+ L+IPD
Sbjct: 688 RISVEDNNGNMYKSIMLTSQDKTPAVIQRAMLKHNLDSDPAEEYELVQVISEDKELVIPD 747
Query: 678 NANVFYAMSPVAPRDFMLRRK 698
+ANVFYAM+ DF+LR+K
Sbjct: 748 SANVFYAMNSQVNFDFILRKK 768
>gi|4758532 ral guanine nucleotide dissociation stimulator-like 2
[Homo sapiens]
Length = 777
Score = 384 bits (986), Expect = e-106
Identities = 277/735 (37%), Positives = 372/735 (50%), Gaps = 102/735 (13%)
Query: 12 APLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLHYRTSKVRVLRA 71
AP+ W EE EDGAV++V+ R+ R P P P + R LRA
Sbjct: 53 APVSVWDEE-EDGAVFTVTSRQYR---------PLDPLVPMPPPRSS--------RRLRA 94
Query: 72 ARLERLVGELVFGDRE-QDPSFMPAFLATYRTFVPTACLLGFLLPPMPP-PPPPGVEIKK 129
LE LV L+ D SFM AFLAT+R F T LLG + + P E+++
Sbjct: 95 GTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPALLGLMADRLEALESHPTDELER 154
Query: 130 TAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFL---GWAAPGSAEAQ 186
T +SVL +WL HP+DF A L + +FL G+AA
Sbjct: 155 TT----------EVAISVLSTWLASHPEDFGSE-AKGQLDRLESFLLQTGYAAGKGVGGG 203
Query: 187 KAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQGPQLLDF 246
A D + + + P + P +A DP + +L F
Sbjct: 204 SA-----DLIRNLRSRVDPQAPDL---PKPLALPGDPPADPT-------------DVLVF 242
Query: 247 SVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVL 306
D +AEQLTL+D ELF + +CLG +W RDRPG + P+VRATV QFN V G V+
Sbjct: 243 LADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVV 302
Query: 307 GSVLGA------PG------LAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNP 354
SVLGA PG L PQRA+ LEKWIR+A+ CR LRNFSS+ A++SALQS+P
Sbjct: 303 SSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSP 362
Query: 355 IYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPS 414
I+RL+ +WG +R+ L F L QIFS+E+N+ SRE+L QE + E +
Sbjct: 363 IHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSG 422
Query: 415 KPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTL 474
G VPYLGTFL DLVMLD A D LE INF+KRRKE+ +L+ +++LQ C+ Y L
Sbjct: 423 SRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNL 482
Query: 475 SPHPPILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKS 534
P I L LTE QS+R+S +EPP +S P +PR+ R + + + L
Sbjct: 483 QPDHDIQRWLQGLRPLTEAQSHRVSCEVEPPGSSDPPAPRVLRPTLVISQWTEVLGSVGV 542
Query: 535 SSPSGSPGDPSSPTSSVSPGSPP-----------SSPRSRDAPAGSPPASPGPQGPSTKL 583
+P S PS+ P S S D+ S P+ P PS
Sbjct: 543 PTPLVSCDRPSTGGDEAPTTPAPLLTRLAQHMKWPSVSSLDSALESSPSLHSPADPS--- 599
Query: 584 PLSLDLPSPRPF-----ALPLGSPRIPLPAQQS--------------SEARVIRVSID-N 623
LS SPRP + GSP + S S+ R+IRV ++
Sbjct: 600 HLSPPASSPRPSRGHRRSASCGSPLSGGAEEASGGTGYGGEGSGPGASDCRIIRVQMELG 659
Query: 624 DHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGDRVLLIPDNANVFY 683
+ G++Y+SIL+TSQDKAPSV+ R L+K+N A +Y+L Q+LPG+R L IP +ANVFY
Sbjct: 660 EDGSVYKSILVTSQDKAPSVISRVLKKNNRDSAVASEYELVQLLPGERELTIPASANVFY 719
Query: 684 AMSPVAPRDFMLRRK 698
AM A DF+LR++
Sbjct: 720 AMDG-ASHDFLLRQR 733
>gi|24307909 ral guanine nucleotide dissociation stimulator isoform
1 [Homo sapiens]
Length = 914
Score = 381 bits (978), Expect = e-105
Identities = 232/553 (41%), Positives = 315/553 (56%), Gaps = 49/553 (8%)
Query: 198 EAEREQEEEPPQVWTGPPRVAQTSDPDSS-EACAEEEEGLMPQGPQLLDFSVDEVAEQLT 256
E EQ+ P Q P A S + E GL + P LL F D VAEQ T
Sbjct: 336 EPAPEQDPAPSQTLELEPAPAPVPSLQPSWPSPVVAENGLSEEKPHLLVFPPDLVAEQFT 395
Query: 257 LIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLA 316
L+D ELF KV Y CLGS+WSQRD+ G +PT+RATV QFN+V CV+ + LG
Sbjct: 396 LMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTK 455
Query: 317 APQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKL 376
AP RA+ +E WI +A+ CR L+NFSSL AILSALQSN I+RLK++W VSR+ F+KL
Sbjct: 456 APDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKL 515
Query: 377 SQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPP-----GPVPYLGTFLTDL 431
S+IFSDENN+ SRE+L +E ++ + E N P +P G VPYLGTFLTDL
Sbjct: 516 SEIFSDENNYSLSRELLIKEGTSKFATLEMN-PKRAQKRPKETGIIQGTVPYLGTFLTDL 574
Query: 432 VMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLT 491
VMLDTA+ D L G LINFEKRRKE+E++A+I+ LQ C +Y+++P A A +L+
Sbjct: 575 VMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLS 634
Query: 492 EEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGSP---------- 541
E +SY LS +EPP+ S ++ R ++ ++ KR S + A S SGS
Sbjct: 635 ETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSDRQAPSTELSTSGSSHSKSCDQLRC 694
Query: 542 ------------------GDPSSPTSSVSPGSPPSSPRSRD-----APAGSPPASPGPQG 578
G SS ++ P SP ++ + + S P + G
Sbjct: 695 GPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQEKKFWESASQSSPETSGISS 754
Query: 579 PSTKLPLSLDLPSP---------RPFALPLGSPRIPLPAQQSSEARVIRVSIDNDHGNLY 629
S+ S +P L S +PL QQ + +IRVS+D D+GN+Y
Sbjct: 755 ASSSTSSSSASTTPVAATRTHKRSVSGLCNSSSALPLYNQQVGDCCIIRVSLDVDNGNMY 814
Query: 630 RSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGDRVLLIPDNANVFYAMSPVA 689
+SIL+TSQDKAP+V+R+A+ KHN+ + DY+L Q+L DR L IP+NANVFYAM+ A
Sbjct: 815 KSILVTSQDKAPAVIRKAMDKHNLEEEEPEDYELLQILSDDRKLKIPENANVFYAMNSTA 874
Query: 690 PRDFMLRRKEGTR 702
DF+L+++ T+
Sbjct: 875 NYDFVLKKRTFTK 887
Score = 68.2 bits (165), Expect = 3e-11
Identities = 60/218 (27%), Positives = 98/218 (44%), Gaps = 20/218 (9%)
Query: 15 QDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIA----NTFLHYRTSKVRVLR 70
Q+ GEE +G +YS+SLR+ + GG++ + + Y T KVR ++
Sbjct: 65 QEIGEELINGVIYSISLRKVQLHH-------GGNKGQRWLGYENESALNLYETCKVRTVK 117
Query: 71 AARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLL------PPMPPPPPPG 124
A LE+LV LV + D S++ FL TYR F T +L L + G
Sbjct: 118 AGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYG 177
Query: 125 VEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAE 184
+ + ++ A+ S+LG+WL + +DF PP L + ++ PGS
Sbjct: 178 CILPYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDL 237
Query: 185 AQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSD 222
++A LL LE +E + E P+ + P + T +
Sbjct: 238 ERRAHLLLAQ-LEHSEPIEAE--PEALSPVPALKPTPE 272
>gi|108796058 ral guanine nucleotide dissociation stimulator isoform
2 [Homo sapiens]
Length = 859
Score = 381 bits (978), Expect = e-105
Identities = 232/553 (41%), Positives = 315/553 (56%), Gaps = 49/553 (8%)
Query: 198 EAEREQEEEPPQVWTGPPRVAQTSDPDSS-EACAEEEEGLMPQGPQLLDFSVDEVAEQLT 256
E EQ+ P Q P A S + E GL + P LL F D VAEQ T
Sbjct: 281 EPAPEQDPAPSQTLELEPAPAPVPSLQPSWPSPVVAENGLSEEKPHLLVFPPDLVAEQFT 340
Query: 257 LIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLA 316
L+D ELF KV Y CLGS+WSQRD+ G +PT+RATV QFN+V CV+ + LG
Sbjct: 341 LMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTK 400
Query: 317 APQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKL 376
AP RA+ +E WI +A+ CR L+NFSSL AILSALQSN I+RLK++W VSR+ F+KL
Sbjct: 401 APDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKL 460
Query: 377 SQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPP-----GPVPYLGTFLTDL 431
S+IFSDENN+ SRE+L +E ++ + E N P +P G VPYLGTFLTDL
Sbjct: 461 SEIFSDENNYSLSRELLIKEGTSKFATLEMN-PKRAQKRPKETGIIQGTVPYLGTFLTDL 519
Query: 432 VMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLT 491
VMLDTA+ D L G LINFEKRRKE+E++A+I+ LQ C +Y+++P A A +L+
Sbjct: 520 VMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLS 579
Query: 492 EEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGSP---------- 541
E +SY LS +EPP+ S ++ R ++ ++ KR S + A S SGS
Sbjct: 580 ETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSDRQAPSTELSTSGSSHSKSCDQLRC 639
Query: 542 ------------------GDPSSPTSSVSPGSPPSSPRSRD-----APAGSPPASPGPQG 578
G SS ++ P SP ++ + + S P + G
Sbjct: 640 GPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQEKKFWESASQSSPETSGISS 699
Query: 579 PSTKLPLSLDLPSP---------RPFALPLGSPRIPLPAQQSSEARVIRVSIDNDHGNLY 629
S+ S +P L S +PL QQ + +IRVS+D D+GN+Y
Sbjct: 700 ASSSTSSSSASTTPVAATRTHKRSVSGLCNSSSALPLYNQQVGDCCIIRVSLDVDNGNMY 759
Query: 630 RSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGDRVLLIPDNANVFYAMSPVA 689
+SIL+TSQDKAP+V+R+A+ KHN+ + DY+L Q+L DR L IP+NANVFYAM+ A
Sbjct: 760 KSILVTSQDKAPAVIRKAMDKHNLEEEEPEDYELLQILSDDRKLKIPENANVFYAMNSTA 819
Query: 690 PRDFMLRRKEGTR 702
DF+L+++ T+
Sbjct: 820 NYDFVLKKRTFTK 832
Score = 68.2 bits (165), Expect = 3e-11
Identities = 60/218 (27%), Positives = 98/218 (44%), Gaps = 20/218 (9%)
Query: 15 QDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIA----NTFLHYRTSKVRVLR 70
Q+ GEE +G +YS+SLR+ + GG++ + + Y T KVR ++
Sbjct: 10 QEIGEELINGVIYSISLRKVQLHH-------GGNKGQRWLGYENESALNLYETCKVRTVK 62
Query: 71 AARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLL------PPMPPPPPPG 124
A LE+LV LV + D S++ FL TYR F T +L L + G
Sbjct: 63 AGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYG 122
Query: 125 VEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAE 184
+ + ++ A+ S+LG+WL + +DF PP L + ++ PGS
Sbjct: 123 CILPYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDL 182
Query: 185 AQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSD 222
++A LL LE +E + E P+ + P + T +
Sbjct: 183 ERRAHLLLAQ-LEHSEPIEAE--PEALSPVPALKPTPE 217
>gi|23957680 ral guanine nucleotide dissociation stimulator-like 4
[Homo sapiens]
Length = 473
Score = 180 bits (456), Expect = 5e-45
Identities = 121/346 (34%), Positives = 175/346 (50%), Gaps = 22/346 (6%)
Query: 162 PPAHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTS 221
PP +DLG P S A L A E PP P ++S
Sbjct: 144 PPLLADLGPA------LEPESPAALGPPGYLHSAPGPAPAPGEGPPPGTVLEPQSAPESS 197
Query: 222 DPDSSEACAEEEEGLMPQGPQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDR 281
P + E L P + F +AEQLTL+D ELF KV L+ECLG +W Q
Sbjct: 198 CPCRGSVKNQPSEEL----PDMTTFPPRLLAEQLTLMDAELFKKVVLHECLGCIWGQGHL 253
Query: 282 PGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFS 341
G +PTVRAT+A FN +T C+ S LG + A RA+ +E WI++A+ C L NFS
Sbjct: 254 KGNEHMAPTVRATIAHFNRLTNCITTSCLGDHSMRARDRARVVEHWIKVARECLSLNNFS 313
Query: 342 SLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEG 401
S+ I+SAL SNPI +L ++W VS + + ++L + + R++L + + +
Sbjct: 314 SVHVIVSALCSNPIGQLHKTWAGVSSKSMKELKELC-----KKDTAVKRDLLIKAGSFKV 368
Query: 402 SQEEDNTPGSLP---SKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEI 458
+ +E N P + + G VP+LG FLT+L LD+A+PD L+G N KR KE +
Sbjct: 369 ATQERN-PQRVQMRLRRQKKGVVPFLGDFLTELQRLDSAIPDDLDG---NTNKRSKEVRV 424
Query: 459 LARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQSYRLSRVIEP 504
L +Q LQ +Y L P + QL++++SY+LS +EP
Sbjct: 425 LQEMQLLQVAAMNYRLRPLEKFVTYFTRMEQLSDKESYKLSCQLEP 470
>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
sapiens]
Length = 557
Score = 125 bits (314), Expect = 1e-28
Identities = 107/368 (29%), Positives = 177/368 (48%), Gaps = 56/368 (15%)
Query: 210 VWTGPPRVAQTSDPDSSEACAEEEEGLMPQGPQLLDFSVDEVAEQLTLIDLELFSKVRLY 269
V + P+ + +SD ++C + +L + +E A Q+TL+D+ +F ++
Sbjct: 13 VTSATPQGSSSSDSLEGQSCDYASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPE 72
Query: 270 ECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIR 329
E WS++++ A P V A +FN V+ V+ +L A L RA+ L +++
Sbjct: 73 ELASCGWSKKEKHSLA---PNVVAFTRRFNQVSFWVVREILTAQTLKI--RAEILSHFVK 127
Query: 330 IAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSS 389
IA++ EL N SL +++SALQS PI+RL ++W ++R+ +TF KL + S E+N+ +
Sbjct: 128 IAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRT 187
Query: 390 REILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINF 449
RE + SL P +PYLG +L DL+ +D+A P G ++
Sbjct: 188 REYI----------------RSLKMVP---SIPYLGIYLLDLIYIDSAYP--ASGSIMEN 226
Query: 450 EKRRKEW-EILARIQQLQRRCQSYTLSPHPPI------LAALHAQNQLTEEQSYRLSRVI 502
E+R + IL I LQ C L+ P + + + + E+ +Y+LS I
Sbjct: 227 EQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRI 286
Query: 503 EPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGSPGD------PSSPTSSVSPGSP 556
EP + SSPR+ +S+K E + PS G P+ P +SV+ P
Sbjct: 287 EPGS----SSPRL---------VSSK---EDLAGPSAGSGSARFSRRPTCPDTSVAGSLP 330
Query: 557 -PSSPRSR 563
P PR R
Sbjct: 331 TPPVPRHR 338
>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
2 [Homo sapiens]
Length = 1237
Score = 120 bits (302), Expect = 3e-27
Identities = 81/259 (31%), Positives = 128/259 (49%), Gaps = 28/259 (10%)
Query: 247 SVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVL 306
S E+AEQ+TL+D +F + E LG W + D+ +P + T FN ++ V
Sbjct: 1002 SAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNER---TPYIMKTSQHFNDMSNLVA 1058
Query: 307 GSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVS 366
++ +++ RA +EKW+ +A CR L N++ + I SAL + IYRLK++W VS
Sbjct: 1059 SQIMNYADVSS--RANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVS 1116
Query: 367 REPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGT 426
++ + KL + S E + RE +L + PP VPYLG
Sbjct: 1117 KQTKALMDKLQKTVSSEGRFKNLRE-------------------TLKNCNPPA-VPYLGM 1156
Query: 427 FLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHA 486
+LTDL ++ P+ E L+NF K R I+ I+Q Q+ SY + P + L
Sbjct: 1157 YLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQ--TSYRIDHQPKVAQYLLD 1214
Query: 487 QNQLTEEQS-YRLSRVIEP 504
++ + +E + Y LS IEP
Sbjct: 1215 KDLIIDEDTLYELSLKIEP 1233
Score = 33.9 bits (76), Expect = 0.54
Identities = 29/92 (31%), Positives = 42/92 (45%), Gaps = 10/92 (10%)
Query: 490 LTEEQSYRLSRVIEPP---AASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGSPGDPSS 546
L + +S RL R P A S SSP R++SLT L++K+ ++ S P++
Sbjct: 713 LVDGKSPRLCRKFSSPPPLAVSRTSSPVRARKLSLTSPLNSKIGALDLTTSS----SPTT 768
Query: 547 PTSSVSPGSPPSS---PRSRDAPAGSPPASPG 575
T S + PP + P SP SPG
Sbjct: 769 TTQSPAASPPPHTGQIPLDLSRGLSSPEQSPG 800
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 115 bits (288), Expect = 1e-25
Identities = 97/365 (26%), Positives = 160/365 (43%), Gaps = 53/365 (14%)
Query: 144 VVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQ 203
V++VL W+ H QDF + +L K LE+ + + E
Sbjct: 938 VLNVLRHWVSKHSQDFE---TNDELKC----------------KVIGFLEEVMHDPELLT 978
Query: 204 EEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQGPQLLDF---SVDEVAEQLTLIDL 260
+E + R DP ++ EE M +G + F S E+AEQLTL+D
Sbjct: 979 QER--KAAANIIRTLTQEDPGDNQITLEEITQ-MAEGVKAEPFENHSALEIAEQLTLLDH 1035
Query: 261 ELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQR 320
+F K+ E G W + ++ +P + T FN ++ + ++ + A R
Sbjct: 1036 LVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHFNDISNLIASEIIRNEDINA--R 1090
Query: 321 AQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIF 380
+EKW+ +A CR L N++++ I S++ + I+RLK++W VS++ + KL ++
Sbjct: 1091 VSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLV 1150
Query: 381 SDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPD 440
S E + RE L P VPYLG +LTDL ++ P+
Sbjct: 1151 SSEGRFKNLREAL--------------------KNCDPPCVPYLGMYLTDLAFIEEGTPN 1190
Query: 441 MLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQS-YRLS 499
E L+NF K R I+ I+Q Q+ +Y + + L Q+ + +E+S Y S
Sbjct: 1191 YTEDGLVNFSKMRMISHIIREIRQFQQ--TAYKIEHQAKVTQYLLDQSFVMDEESLYESS 1248
Query: 500 RVIEP 504
IEP
Sbjct: 1249 LRIEP 1253
>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 1 [Homo sapiens]
Length = 1273
Score = 115 bits (288), Expect = 1e-25
Identities = 97/365 (26%), Positives = 160/365 (43%), Gaps = 53/365 (14%)
Query: 144 VVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQ 203
V++VL W+ H QDF + +L K LE+ + + E
Sbjct: 954 VLNVLRHWVSKHSQDFE---TNDELKC----------------KVIGFLEEVMHDPELLT 994
Query: 204 EEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQGPQLLDF---SVDEVAEQLTLIDL 260
+E + R DP ++ EE M +G + F S E+AEQLTL+D
Sbjct: 995 QER--KAAANIIRTLTQEDPGDNQITLEEITQ-MAEGVKAEPFENHSALEIAEQLTLLDH 1051
Query: 261 ELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQR 320
+F K+ E G W + ++ +P + T FN ++ + ++ + A R
Sbjct: 1052 LVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHFNDISNLIASEIIRNEDINA--R 1106
Query: 321 AQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIF 380
+EKW+ +A CR L N++++ I S++ + I+RLK++W VS++ + KL ++
Sbjct: 1107 VSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLV 1166
Query: 381 SDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPD 440
S E + RE L P VPYLG +LTDL ++ P+
Sbjct: 1167 SSEGRFKNLREAL--------------------KNCDPPCVPYLGMYLTDLAFIEEGTPN 1206
Query: 441 MLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQS-YRLS 499
E L+NF K R I+ I+Q Q+ +Y + + L Q+ + +E+S Y S
Sbjct: 1207 YTEDGLVNFSKMRMISHIIREIRQFQQ--TAYKIEHQAKVTQYLLDQSFVMDEESLYESS 1264
Query: 500 RVIEP 504
IEP
Sbjct: 1265 LRIEP 1269
>gi|24797101 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 2 [Homo sapiens]
Length = 489
Score = 115 bits (288), Expect = 1e-25
Identities = 97/365 (26%), Positives = 160/365 (43%), Gaps = 53/365 (14%)
Query: 144 VVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQ 203
V++VL W+ H QDF + +L K LE+ + + E
Sbjct: 170 VLNVLRHWVSKHSQDFE---TNDELKC----------------KVIGFLEEVMHDPELLT 210
Query: 204 EEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQGPQLLDF---SVDEVAEQLTLIDL 260
+E + R DP ++ EE M +G + F S E+AEQLTL+D
Sbjct: 211 QER--KAAANIIRTLTQEDPGDNQITLEEITQ-MAEGVKAEPFENHSALEIAEQLTLLDH 267
Query: 261 ELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQR 320
+F K+ E G W + ++ +P + T FN ++ + ++ + A R
Sbjct: 268 LVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHFNDISNLIASEIIRNEDINA--R 322
Query: 321 AQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIF 380
+EKW+ +A CR L N++++ I S++ + I+RLK++W VS++ + KL ++
Sbjct: 323 VSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLV 382
Query: 381 SDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPD 440
S E + RE L P VPYLG +LTDL ++ P+
Sbjct: 383 SSEGRFKNLREAL--------------------KNCDPPCVPYLGMYLTDLAFIEEGTPN 422
Query: 441 MLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQS-YRLS 499
E L+NF K R I+ I+Q Q+ +Y + + L Q+ + +E+S Y S
Sbjct: 423 YTEDGLVNFSKMRMISHIIREIRQFQQ--TAYKIEHQAKVTQYLLDQSFVMDEESLYESS 480
Query: 500 RVIEP 504
IEP
Sbjct: 481 LRIEP 485
>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
sapiens]
Length = 583
Score = 112 bits (281), Expect = 9e-25
Identities = 93/321 (28%), Positives = 158/321 (49%), Gaps = 37/321 (11%)
Query: 243 LLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVT 302
+L + +E A Q+TL+D+ +F ++ E W+++++ +A P A +FN V+
Sbjct: 45 VLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSA---PNAVAFTRRFNHVS 101
Query: 303 GCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSW 362
V+ +L A L RA+ L +I+ A++ EL N +L A++S LQS PI+RL ++W
Sbjct: 102 FWVVREILHAQTLKI--RAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTW 159
Query: 363 GAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVP 422
+SR+ +TF KL + S E+N+ R+ + SL P +P
Sbjct: 160 ALLSRKDKTTFEKLEYVMSKEDNYKRLRDYI----------------SSLKMTP---CIP 200
Query: 423 YLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEW-EILARIQQLQRRCQSYTLSPHPPIL 481
YLG +L+DL +D+A P G ++ E+R IL I LQ+ C+ Y + P +
Sbjct: 201 YLGIYLSDLTYIDSAYPS--TGSILENEQRSNLMNNILRIISDLQQSCE-YDIPMLPHVQ 257
Query: 482 AALHA------QNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSS 535
L++ + E+ +Y+LS IE P S P S R + + ++ + KS
Sbjct: 258 KYLNSVQYIEELQKFVEDDNYKLSLKIE-PGTSTPRSAASREDLVGPEVGASPQSGRKSV 316
Query: 536 SPSGS--PGDPSSPTSSVSPG 554
+ G+ P P SP + + G
Sbjct: 317 AAEGALLPQTPPSPRNLIPHG 337
>gi|154689780 son of sevenless homolog 2 [Homo sapiens]
Length = 1332
Score = 104 bits (260), Expect = 2e-22
Identities = 139/560 (24%), Positives = 223/560 (39%), Gaps = 116/560 (20%)
Query: 64 SKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPPPPP 123
S + +++ + +L+ L + DP+F+ FL TYR+F LL L+ P P
Sbjct: 594 SGIPIIKGGTVVKLIERLTY-HMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPE 652
Query: 124 GVEIKKTAVQ--------DLS-FNKNL-----RAVVSVLGSWLQDHPQDFRDPPAHSDLG 169
+ K A++ DL F K +++V W++ H DF DL
Sbjct: 653 PTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFE-----RDLE 707
Query: 170 SVRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQE------------EEPPQVWTGPPRV 217
+ + + +A K K +E + R+++ E PP PP
Sbjct: 708 LLERLESFISSVRGKAMK--KWVESIAKIIRRKKQAQANGVSHNITFESPP-----PPIE 760
Query: 218 AQTSDPDSSEACAEEEEGLMPQGPQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWS 277
S P E L+ E+A QLTL++ +L+ KV+ E +GSVW+
Sbjct: 761 WHISKPGQFETF------------DLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWT 808
Query: 278 QRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCREL 337
+ D+ SP + + +T ++ A +R L + I I Q ++L
Sbjct: 809 KEDK---EINSPNLLKMIRHTTNLTLWFEKCIVEAENF--EERVAVLSRIIEILQVFQDL 863
Query: 338 RNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEE 397
NF+ + I+SA+ S +YRL ++ A+ R+IL +E
Sbjct: 864 NNFNGVLEIVSAVNSVSVYRLDHTFEALQER--------------------KRKIL--DE 901
Query: 398 ATEGSQEE-DNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLE---GDLINFEKRR 453
A E SQ+ L S PP VP+ G +LT+++ + D L+ DLINF KRR
Sbjct: 902 AVELSQDHFKKYLVKLKSINPP-CVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRR 960
Query: 454 KEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQL-----TEEQSYRLSRVIEPPAAS 508
K EI IQQ Q Q Y L P + N + E Y ++ +E +
Sbjct: 961 KVAEITGEIQQYQN--QPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRN 1018
Query: 509 CPSSPRIRRRISLTKR---LSAKLAREKSSS------PSGSPGDP--------------- 544
C PR R+ + + + + R S+S P+ +P
Sbjct: 1019 CKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELES 1078
Query: 545 --SSPTSSVSPGSPPSSPRS 562
S+PTS +P +PP S S
Sbjct: 1079 TVSAPTSPNTPSTPPVSASS 1098
>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
Length = 1333
Score = 103 bits (257), Expect = 6e-22
Identities = 144/597 (24%), Positives = 234/597 (39%), Gaps = 110/597 (18%)
Query: 66 VRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPPPPPGV 125
+ +++A + +L+ L + DP+F+ FL TYR+F LL ++ P P
Sbjct: 598 IPIIKAGTVIKLIERLTY-HMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPT 656
Query: 126 EIKKTAVQ--DLSFNKNLRA------------VVSVLGSWLQDHPQDF-RDPPAHSDLGS 170
E + A++ D + L+ V++V W++ H DF RD L
Sbjct: 657 EADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYL---LQR 713
Query: 171 VRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQEEEPPQVWT---GPPRVA-QTSDPDSS 226
+ F+G G A + E + + ++ + ++ P T PP V S P
Sbjct: 714 MEEFIG-TVRGKAMKKWVESITK-IIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHI 771
Query: 227 EACAEEEEGLMPQGPQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAG 286
E LL E+A QLTL++ +L+ V+ E +GSVW++ D+
Sbjct: 772 ETF------------DLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDK---EI 816
Query: 287 ASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAI 346
SP + + +T ++ L +R + + I I Q +EL NF+ + +
Sbjct: 817 NSPNLLKMIRHTTNLTLWFEKCIVETENL--EERVAVVSRIIEILQVFQELNNFNGVLEV 874
Query: 347 LSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEE- 405
+SA+ S+P+YRL ++ + SR+ EEA E S++
Sbjct: 875 VSAMNSSPVYRLDHTF----------------------EQIPSRQKKILEEAHELSEDHY 912
Query: 406 DNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLE---GDLINFEKRRKEWEILARI 462
L S PP VP+ G +LT+++ + P++L+ +LINF KRRK EI I
Sbjct: 913 KKYLAKLRSINPP-CVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEI 971
Query: 463 QQLQRRCQSYTLSPHPPILAALHAQNQL-----TEEQSYRLSRVIEPPAASCPSSPRIRR 517
QQ Q Q Y L I N + E Y ++ +E + PR +
Sbjct: 972 QQYQN--QPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPK 1029
Query: 518 RISLTKRLSAKLAREKSSSPSGSPGDPSSPTSSVSPGSPPSSPRSRDAPAGSPPASPGPQ 577
+ S + SPG PS+PR P +P Q
Sbjct: 1030 KYSYPLK---------------------------SPGVRPSNPR----PGTMRHPTPLQQ 1058
Query: 578 GPSTKLPLSLDLPSPRPFALPLGSPRIPL---PAQQSSEARVIRVSIDNDHGNLYRS 631
P + A SPR PL PA +S + D+DH + + S
Sbjct: 1059 EPRKISYSRIPESETESTASAPNSPRTPLTPPPASGASSTTDVCSVFDSDHSSPFHS 1115
Score = 30.4 bits (67), Expect = 5.9
Identities = 53/243 (21%), Positives = 83/243 (34%), Gaps = 37/243 (15%)
Query: 396 EEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKE 455
E TE + N+P + P PPP T + + D + P D + +
Sbjct: 1070 ESETESTASAPNSPRT-PLTPPPASGASSTTDVCSVFDSDHSSPFHSSNDTVFIQVTLPH 1128
Query: 456 WEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQSYRL-SRVIEPPAASCPSSPR 514
A + + + + PP+ ++ E ++ S+ ++ P A P P
Sbjct: 1129 GPRSASVSSISLTKGTDEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPT 1188
Query: 515 IRR---RISLTKRLSAKLAREK----------------SSSPSGSPGDPSSPTSSVSPGS 555
+ R S++ R S E SSSP P S
Sbjct: 1189 SKAYSPRYSISDRTSISDPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGKKSDHGNAF 1248
Query: 556 PPSSPRSRDAPAGSPPASPGPQG-----PSTKLPLSLDLPSPRPFALPLGSPRIPLPAQQ 610
P+SP P PP +P P G PS L +DL S + P +P P Q
Sbjct: 1249 FPNSPSPFTPP---PPQTPSPHGTRRHLPSPPLTQEVDLHS-------IAGPPVP-PRQS 1297
Query: 611 SSE 613
+S+
Sbjct: 1298 TSQ 1300
>gi|7662334 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 2 [Homo sapiens]
Length = 689
Score = 89.0 bits (219), Expect = 1e-17
Identities = 68/266 (25%), Positives = 124/266 (46%), Gaps = 31/266 (11%)
Query: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309
E+AE LT ++ + F ++ + V G +PT+ ++A FN ++ V V
Sbjct: 155 ELAEHLTFLEHKSFRRISFTDYQSYVIH-----GCLENNPTLERSIALFNGISKWVQLMV 209
Query: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369
L P QRA+ + K+I +A++ +L+NF++L A++ L + I RLK + +S E
Sbjct: 210 LSKP--TPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEV 267
Query: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429
+ +++++ S N+ + R+ + + +P LG L
Sbjct: 268 TKNWNEMTELVSSNGNYCNYRKAFADCDGFK--------------------IPILGVHLK 307
Query: 430 DLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQ 489
DL+ + PD E + +N K + L+ + LQ S+ L P+ ++ L
Sbjct: 308 DLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQN--ASHHLEPNMDLINLLTLSLD 365
Query: 490 L--TEEQSYRLSRVIEPPAASCPSSP 513
L TE+ Y+LS V+EP + P+SP
Sbjct: 366 LYHTEDDIYKLSLVLEPRNSKSPTSP 391
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 86.3 bits (212), Expect = 9e-17
Identities = 82/282 (29%), Positives = 129/282 (45%), Gaps = 41/282 (14%)
Query: 229 CAEEEEGLMPQGPQ-----LLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPG 283
CA + L +G L DF E+AEQLTL+D ELF K+ + E L +W++
Sbjct: 835 CATSSQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVL--LWAKEQNEE 892
Query: 284 AAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSL 343
SP + FN ++ V ++ A R + L K+I+I + R+L NF+S
Sbjct: 893 K---SPNLTQFTEHFNNMSYWVRSIIMLQE--KAQDRERLLLKFIKIMKHLRKLNNFNSY 947
Query: 344 RAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQ 403
AILSAL S PI RL+ W + E L+ + + ++ + R L + E
Sbjct: 948 LAILSALDSAPIRRLE--WQKQTSEGLAEY---CTLIDSSSSFRAYRAALSEVE------ 996
Query: 404 EEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQ 463
P +PYLG L DL + PD ++G +NF KR +++ IL ++
Sbjct: 997 --------------PPCIPYLGLILQDLTFVHLGNPDYIDGK-VNFSKRWQQFNILDSMR 1041
Query: 464 QLQRRCQSYTLSPHPPILAALH-AQNQLTEEQSYRLSRVIEP 504
Q+ Y + + I+ + + L EE + LS I+P
Sbjct: 1042 CFQQ--AHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKP 1081
>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
sapiens]
Length = 1077
Score = 86.3 bits (212), Expect = 9e-17
Identities = 82/282 (29%), Positives = 129/282 (45%), Gaps = 41/282 (14%)
Query: 229 CAEEEEGLMPQGPQ-----LLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPG 283
CA + L +G L DF E+AEQLTL+D ELF K+ + E L +W++
Sbjct: 817 CATSSQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVL--LWAKEQNEE 874
Query: 284 AAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSL 343
SP + FN ++ V ++ A R + L K+I+I + R+L NF+S
Sbjct: 875 K---SPNLTQFTEHFNNMSYWVRSIIMLQE--KAQDRERLLLKFIKIMKHLRKLNNFNSY 929
Query: 344 RAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQ 403
AILSAL S PI RL+ W + E L+ + + ++ + R L + E
Sbjct: 930 LAILSALDSAPIRRLE--WQKQTSEGLAEY---CTLIDSSSSFRAYRAALSEVE------ 978
Query: 404 EEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQ 463
P +PYLG L DL + PD ++G +NF KR +++ IL ++
Sbjct: 979 --------------PPCIPYLGLILQDLTFVHLGNPDYIDGK-VNFSKRWQQFNILDSMR 1023
Query: 464 QLQRRCQSYTLSPHPPILAALH-AQNQLTEEQSYRLSRVIEP 504
Q+ Y + + I+ + + L EE + LS I+P
Sbjct: 1024 CFQQ--AHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKP 1063
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 85.5 bits (210), Expect = 2e-16
Identities = 69/267 (25%), Positives = 125/267 (46%), Gaps = 32/267 (11%)
Query: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309
E+AE LT ++ + F ++ + V G +PT+ ++A FN ++ V V
Sbjct: 155 ELAEHLTFLEHKSFRRISFTDYQSYVIH-----GCLENNPTLERSIALFNGISKWVQLMV 209
Query: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369
L P QRA+ + K+I +A++ +L+NF++L A++ L + I RLK + +S E
Sbjct: 210 LSKP--TPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEV 267
Query: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429
+ +++++ S N+ + R+ + + +P LG L
Sbjct: 268 TKNWNEMTELVSSNGNYCNYRKAFADCDGFK--------------------IPILGVHLK 307
Query: 430 DLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQ 489
DL+ + PD E + +N K + L+ + LQ S+ L P+ ++ L
Sbjct: 308 DLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQN--ASHHLEPNMDLINLLTLSLD 365
Query: 490 L--TEEQSYRLSRVIEP-PAASCPSSP 513
L TE+ Y+LS V+EP + S P+SP
Sbjct: 366 LYHTEDDIYKLSLVLEPRNSKSQPTSP 392
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 85.5 bits (210), Expect = 2e-16
Identities = 69/267 (25%), Positives = 125/267 (46%), Gaps = 32/267 (11%)
Query: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309
E+AE LT ++ + F ++ + V G +PT+ ++A FN ++ V V
Sbjct: 155 ELAEHLTFLEHKSFRRISFTDYQSYVIH-----GCLENNPTLERSIALFNGISKWVQLMV 209
Query: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369
L P QRA+ + K+I +A++ +L+NF++L A++ L + I RLK + +S E
Sbjct: 210 LSKP--TPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEV 267
Query: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429
+ +++++ S N+ + R+ + + +P LG L
Sbjct: 268 TKNWNEMTELVSSNGNYCNYRKAFADCDGFK--------------------IPILGVHLK 307
Query: 430 DLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQ 489
DL+ + PD E + +N K + L+ + LQ S+ L P+ ++ L
Sbjct: 308 DLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQN--ASHHLEPNMDLINLLTLSLD 365
Query: 490 L--TEEQSYRLSRVIEP-PAASCPSSP 513
L TE+ Y+LS V+EP + S P+SP
Sbjct: 366 LYHTEDDIYKLSLVLEPRNSKSQPTSP 392
>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 81.6 bits (200), Expect = 2e-15
Identities = 71/266 (26%), Positives = 120/266 (45%), Gaps = 29/266 (10%)
Query: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309
E+AE LT ++ F K+ + V G +P + ++ FN+V+ V +
Sbjct: 157 ELAEHLTYLEYRSFCKILFQDYHSFVTH-----GCTVDNPVLERFISLFNSVSQWVQLMI 211
Query: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369
L P APQRA + ++ +A++ +L+NF++L A++ L + I RLK + VS E
Sbjct: 212 LSKP--TAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPET 269
Query: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429
+ + L+++ + N+ + R L A G + P LG L
Sbjct: 270 IKLWEGLTELVTATGNYGNYRRRL---AACVGFR-----------------FPILGVHLK 309
Query: 430 DLVMLDTALPDMLE--GDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQ 487
DLV L ALPD L+ +N K ++ + IL + + +P L +
Sbjct: 310 DLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLD 369
Query: 488 NQLTEEQSYRLSRVIEPPAASCPSSP 513
TE++ Y+LS EP + S P+SP
Sbjct: 370 QYQTEDELYQLSLQREPRSKSSPTSP 395
>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 81.6 bits (200), Expect = 2e-15
Identities = 71/266 (26%), Positives = 120/266 (45%), Gaps = 29/266 (10%)
Query: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309
E+AE LT ++ F K+ + V G +P + ++ FN+V+ V +
Sbjct: 157 ELAEHLTYLEYRSFCKILFQDYHSFVTH-----GCTVDNPVLERFISLFNSVSQWVQLMI 211
Query: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369
L P APQRA + ++ +A++ +L+NF++L A++ L + I RLK + VS E
Sbjct: 212 LSKP--TAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPET 269
Query: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429
+ + L+++ + N+ + R L A G + P LG L
Sbjct: 270 IKLWEGLTELVTATGNYGNYRRRL---AACVGFR-----------------FPILGVHLK 309
Query: 430 DLVMLDTALPDMLE--GDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQ 487
DLV L ALPD L+ +N K ++ + IL + + +P L +
Sbjct: 310 DLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLD 369
Query: 488 NQLTEEQSYRLSRVIEPPAASCPSSP 513
TE++ Y+LS EP + S P+SP
Sbjct: 370 QYQTEDELYQLSLQREPRSKSSPTSP 395
>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 81.6 bits (200), Expect = 2e-15
Identities = 71/266 (26%), Positives = 120/266 (45%), Gaps = 29/266 (10%)
Query: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309
E+AE LT ++ F K+ + V G +P + ++ FN+V+ V +
Sbjct: 157 ELAEHLTYLEYRSFCKILFQDYHSFVTH-----GCTVDNPVLERFISLFNSVSQWVQLMI 211
Query: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369
L P APQRA + ++ +A++ +L+NF++L A++ L + I RLK + VS E
Sbjct: 212 LSKP--TAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPET 269
Query: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429
+ + L+++ + N+ + R L A G + P LG L
Sbjct: 270 IKLWEGLTELVTATGNYGNYRRRL---AACVGFR-----------------FPILGVHLK 309
Query: 430 DLVMLDTALPDMLE--GDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQ 487
DLV L ALPD L+ +N K ++ + IL + + +P L +
Sbjct: 310 DLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLD 369
Query: 488 NQLTEEQSYRLSRVIEPPAASCPSSP 513
TE++ Y+LS EP + S P+SP
Sbjct: 370 QYQTEDELYQLSLQREPRSKSSPTSP 395
>gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]
Length = 673
Score = 74.3 bits (181), Expect = 4e-13
Identities = 71/263 (26%), Positives = 110/263 (41%), Gaps = 30/263 (11%)
Query: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309
E+A+ LT ++ F + + V G+ P + +V N+V+ V V
Sbjct: 204 ELAQHLTYLEFRSFQAITPQDLRSYVLQ-----GSVRGCPALEGSVGLSNSVSRWVQVMV 258
Query: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369
L PG QRAQ L+K+I +AQR +L+NF++L A+ L + I RLK S +S +
Sbjct: 259 LSRPGPL--QRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDS 316
Query: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429
+L+++ + NN+ R G + +P LG L
Sbjct: 317 TKALLELTELLASHNNYARYRRTW---AGCAGFR-----------------LPVLGVHLK 356
Query: 430 DLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQ 489
DLV L A PD L ++ K + L + LQ + + + L L
Sbjct: 357 DLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLF 416
Query: 490 LTEEQSYRLSRVIEPPAASCPSS 512
TE++ Y LS EP CP S
Sbjct: 417 YTEDEIYELSYAREP---RCPKS 436
>gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo
sapiens]
Length = 659
Score = 74.3 bits (181), Expect = 4e-13
Identities = 71/263 (26%), Positives = 110/263 (41%), Gaps = 30/263 (11%)
Query: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309
E+A+ LT ++ F + + V G+ P + +V N+V+ V V
Sbjct: 190 ELAQHLTYLEFRSFQAITPQDLRSYVLQ-----GSVRGCPALEGSVGLSNSVSRWVQVMV 244
Query: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369
L PG QRAQ L+K+I +AQR +L+NF++L A+ L + I RLK S +S +
Sbjct: 245 LSRPGPL--QRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDS 302
Query: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429
+L+++ + NN+ R G + +P LG L
Sbjct: 303 TKALLELTELLASHNNYARYRRTW---AGCAGFR-----------------LPVLGVHLK 342
Query: 430 DLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQ 489
DLV L A PD L ++ K + L + LQ + + + L L
Sbjct: 343 DLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLF 402
Query: 490 LTEEQSYRLSRVIEPPAASCPSS 512
TE++ Y LS EP CP S
Sbjct: 403 YTEDEIYELSYAREP---RCPKS 422
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
sapiens]
Length = 762
Score = 74.3 bits (181), Expect = 4e-13
Identities = 66/264 (25%), Positives = 115/264 (43%), Gaps = 29/264 (10%)
Query: 249 DEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGS 308
+E++E LT ++ + F ++ + + + +PT+ ++A N ++ V
Sbjct: 207 EELSEHLTYLEFKSFRRISFSDYQNYLVNS-----CVKENPTMERSIALCNGISQWVQLM 261
Query: 309 VLGAPGLAAPQ-RAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSR 367
VL P PQ RA+ K+I++AQ+ +L+NF++L A++ L + I RLK + V
Sbjct: 262 VLSRP---TPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318
Query: 368 EPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTF 427
E +++++ S N+ + R E T+ +P LG
Sbjct: 319 EINKVLGEMTELLSSSRNYDNYRRA--YGECTDFK------------------IPILGVH 358
Query: 428 LTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQ 487
L DL+ L A+PD LE +N K + ++ + QLQ + L L
Sbjct: 359 LKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLD 418
Query: 488 NQLTEEQSYRLSRVIEPPAASCPS 511
TE++ Y LS EP PS
Sbjct: 419 LYYTEDEIYELSYAREPRNHRAPS 442
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
sapiens]
Length = 797
Score = 72.8 bits (177), Expect = 1e-12
Identities = 64/257 (24%), Positives = 113/257 (43%), Gaps = 29/257 (11%)
Query: 249 DEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGS 308
+E++E LT ++ + F ++ + + + +PT+ ++A N ++ V
Sbjct: 207 EELSEHLTYLEFKSFRRISFSDYQNYLVNS-----CVKENPTMERSIALCNGISQWVQLM 261
Query: 309 VLGAPGLAAPQ-RAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSR 367
VL P PQ RA+ K+I++AQ+ +L+NF++L A++ L + I RLK + V
Sbjct: 262 VLSRP---TPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318
Query: 368 EPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTF 427
E +++++ S N+ + R E T+ +P LG
Sbjct: 319 EINKVLGEMTELLSSSRNYDNYRRA--YGECTDFK------------------IPILGVH 358
Query: 428 LTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQ 487
L DL+ L A+PD LE +N K + ++ + QLQ + L L
Sbjct: 359 LKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLD 418
Query: 488 NQLTEEQSYRLSRVIEP 504
TE++ Y LS EP
Sbjct: 419 LYYTEDEIYELSYAREP 435
>gi|40255197 RasGEF domain family, member 1C [Homo sapiens]
Length = 466
Score = 68.9 bits (167), Expect = 2e-11
Identities = 92/419 (21%), Positives = 167/419 (39%), Gaps = 52/419 (12%)
Query: 41 PAEGPGGSQAPSPIANTFLHYRTSKVRVLRAARLERLVGELV-FGDREQDPSFMPAFLAT 99
P E G QA P+ + +A LE L+ LV D + +++ FL +
Sbjct: 20 PTEPTDGEQAGQPLLDG----------APSSASLETLIQHLVPTADYYPEKAYIFTFLLS 69
Query: 100 YRTFVPTACLLGFLLPPMPPPPPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDF 159
R F+ LL + ++ K + K ++ +L W + P+DF
Sbjct: 70 SRLFIEPRELLARVCHLCIEQQ----QLDKPVLDKARVRKFGPKLLQLLAEWTETFPRDF 125
Query: 160 RDPPAHSDLGSVRTFLGWAAP-GSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVA 218
++ S +G ++ +G AP A ++ +LL+ ++ ++ V P
Sbjct: 126 QE---ESTIGHLKDVVGRIAPCDEAYRKRMHQLLQALHQKLAALRQGPEGLVGADKPISY 182
Query: 219 QTSDPDSSEACAEEEEGLMPQGPQLLDFSVDE--VAEQLTLIDLELFSKVRLYECLGSVW 276
+T P S +LL D +A+QLT ++LE + E + +
Sbjct: 183 RTKPPASIHR-------------ELLGVCSDPYTLAQQLTHVELERLRHIGPEEFVQAFV 229
Query: 277 SQ----RDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQ 332
++ +P + + + A V FN + C L + QRAQ +E +I +A+
Sbjct: 230 NKDPLASTKPCFSDKTSNLEAYVKWFNRL--CYLVATEICMPAKKKQRAQVIEFFIDVAR 287
Query: 333 RCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREI 392
C + NF+SL AI+S + +P+ RLK++W V + ++ F E+ +
Sbjct: 288 ECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV---------RTAKFFILEHQMDPTGNF 338
Query: 393 LFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEK 451
A G+ T S K +P+ + D+ L+ + L +NFEK
Sbjct: 339 CNYRTALRGAAHRSLTAHSSREKI---VIPFFSLLIKDIYFLNEGCANRLPNGHVNFEK 394
>gi|117168263 RasGEF domain family, member 1A [Homo sapiens]
Length = 481
Score = 68.2 bits (165), Expect = 3e-11
Identities = 102/416 (24%), Positives = 175/416 (42%), Gaps = 61/416 (14%)
Query: 69 LRAARLERLVGELV-FGDREQDPSFMPAFLATYRTFVPTACLL---GFLLPPMPPPPPPG 124
L + LE L+ LV D D +++ FL + R F+P LL G + G
Sbjct: 45 LISGSLEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAG 104
Query: 125 VEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAE 184
E K SF+ +V +L W + P DF+D A ++L ++ + +
Sbjct: 105 PEKAKLK----SFSAK---IVQLLKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGT 157
Query: 185 AQKAEKLLED--FLEEAEREQEEE------PPQVWTGPPRVAQTSDPDSSEACAEEEEGL 236
+KA + L A R Q +E PP V GP + +T P + +
Sbjct: 158 VKKAIAQMTQSLLLSLAARSQLQELREKLRPPAVDKGP--ILKTKPPAAQK--------- 206
Query: 237 MPQGPQLLDFSVDEV--AEQLTLIDLELFSKV------RLYECLGSVWSQRDRPGAAGAS 288
+L D + A+QLT I+L+ S + ++ + S+ + R R G +
Sbjct: 207 -----DILGVCCDPLVLAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCR-GDLTKT 260
Query: 289 PTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILS 348
++ A FN ++ V V + R + LE +I +A+ C + NF+S+ AI+S
Sbjct: 261 YSLEAYDNWFNCLSMLVATEVCRV--VKKKHRTRMLEFFIDVARECFNIGNFNSMMAIIS 318
Query: 349 ALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNT 408
+ +P+ RLK++W S+ + F L +N + R L + AT+ SQ +++
Sbjct: 319 GMNLSPVARLKKTW---SKVKTAKFDVLEHHMDPSSNFCNYRTAL--QGATQRSQMANSS 373
Query: 409 PGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQ 464
+ +P F+ D+ L + L INF +K WEI +I +
Sbjct: 374 REKI-------VIPVFNLFVKDIYFLHKIHTNHLPNGHINF---KKFWEISRQIHE 419
>gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1
[Homo sapiens]
Length = 456
Score = 68.2 bits (165), Expect = 3e-11
Identities = 77/289 (26%), Positives = 126/289 (43%), Gaps = 38/289 (13%)
Query: 224 DSSEACAE--EEEGLMPQGPQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVW-SQRD 280
DS EA EE + P ++ ++VA LT ELF V E + V+ +R
Sbjct: 193 DSYEALVPLPEEIQVSPGDTEIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERG 252
Query: 281 RPGAAGASPTVRATVAQFNTVTGCVLGSVL--GAPGLAAPQRAQRLEKWIRIAQRCRELR 338
R A + + + + VT V VL APG +RAQ L+K+I+IA C++ +
Sbjct: 253 RRETAN----LELLLQRCSEVTHWVATEVLLCEAPG----KRAQLLKKFIKIAALCKQNQ 304
Query: 339 NFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEA 398
+ S A++ L + + RL+ +W + + + FRK + NH S RE++
Sbjct: 305 DLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVI----- 359
Query: 399 TEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEI 458
SK P +P++ L DL L +++G L+N EK E
Sbjct: 360 ---------------SKMKPPVIPFVPLILKDLTFLHEGSKTLVDG-LVNIEKLHSVAEK 403
Query: 459 LARIQQLQRR--CQSYTLSPHPPILAALHAQNQLTEEQS--YRLSRVIE 503
+ I++ + R C SP+ A Q Q+ + Q+ + LS +E
Sbjct: 404 VRTIRKYRSRPLCLDMEASPNHLQTKAYVRQFQVIDNQNLLFELSYKLE 452
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,852,906
Number of Sequences: 37866
Number of extensions: 2087127
Number of successful extensions: 29168
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 370
Number of HSP's successfully gapped in prelim test: 1174
Number of HSP's that attempted gapping in prelim test: 16929
Number of HSP's gapped (non-prelim): 10856
length of query: 710
length of database: 18,247,518
effective HSP length: 109
effective length of query: 601
effective length of database: 14,120,124
effective search space: 8486194524
effective search space used: 8486194524
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.