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Search of human proteins with 23943858
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23943858 sorting nexin 8 [Homo sapiens]
(465 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23943858 sorting nexin 8 [Homo sapiens] 924 0.0
gi|23397574 sorting nexin 33 [Homo sapiens] 64 2e-10
gi|157057545 sorting nexin 18 isoform a [Homo sapiens] 62 1e-09
gi|4507145 sorting nexin 4 [Homo sapiens] 62 1e-09
gi|23111038 sorting nexin 2 [Homo sapiens] 61 2e-09
gi|224177511 sorting nexin 18 isoform c [Homo sapiens] 60 5e-09
gi|157057543 sorting nexin 18 isoform b [Homo sapiens] 60 5e-09
gi|153791707 sorting nexin family member 30 [Homo sapiens] 57 4e-08
gi|7706706 sorting nexin 9 [Homo sapiens] 55 1e-07
gi|23111055 sorting nexin 7 isoform b [Homo sapiens] 50 3e-06
gi|194294540 sorting nexin 7 isoform a [Homo sapiens] 50 3e-06
gi|23111032 sorting nexin 1 isoform b [Homo sapiens] 49 7e-06
gi|31543452 PX domain containing serine/threonine kinase [Homo s... 49 7e-06
gi|23111034 sorting nexin 1 isoform a [Homo sapiens] 48 2e-05
gi|23111036 sorting nexin 1 isoform c [Homo sapiens] 45 1e-04
gi|24797143 sorting nexin 14 isoform b [Homo sapiens] 45 2e-04
gi|24797145 sorting nexin 14 isoform a [Homo sapiens] 45 2e-04
gi|23111026 sorting nexin 11 [Homo sapiens] 45 2e-04
gi|23111028 sorting nexin 11 [Homo sapiens] 45 2e-04
gi|4507143 sorting nexin 3 isoform a [Homo sapiens] 44 2e-04
gi|23111030 sorting nexin 12 [Homo sapiens] 42 0.001
gi|154091028 sorting nexin 29 [Homo sapiens] 41 0.003
gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [H... 40 0.003
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 40 0.003
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 40 0.003
gi|7661890 sorting nexin 17 [Homo sapiens] 40 0.003
gi|23111023 sorting nexin 10 [Homo sapiens] 40 0.006
gi|31742501 sorting nexin family member 27 [Homo sapiens] 39 0.013
gi|23238244 sorting nexin 16 isoform a [Homo sapiens] 38 0.022
gi|23238246 sorting nexin 16 isoform a [Homo sapiens] 38 0.022
>gi|23943858 sorting nexin 8 [Homo sapiens]
Length = 465
Score = 924 bits (2387), Expect = 0.0
Identities = 465/465 (100%), Positives = 465/465 (100%)
Query: 1 MTGRAMDPLPAAAVGAAAEAEADEEADPPASDLPTPQAIEPQAIVQQVPAPSRMQMPQGN 60
MTGRAMDPLPAAAVGAAAEAEADEEADPPASDLPTPQAIEPQAIVQQVPAPSRMQMPQGN
Sbjct: 1 MTGRAMDPLPAAAVGAAAEAEADEEADPPASDLPTPQAIEPQAIVQQVPAPSRMQMPQGN 60
Query: 61 PLLLSHTLQELLARDTVQVELIPEKKGLFLKHVEYEVSSQRFKSSVYRRYNDFVVFQEML 120
PLLLSHTLQELLARDTVQVELIPEKKGLFLKHVEYEVSSQRFKSSVYRRYNDFVVFQEML
Sbjct: 61 PLLLSHTLQELLARDTVQVELIPEKKGLFLKHVEYEVSSQRFKSSVYRRYNDFVVFQEML 120
Query: 121 LHKFPYRMVPALPPKRMLGADREFIEARRRALKRFVNLVARHPLFSEDVVLKLFLSFSGS 180
LHKFPYRMVPALPPKRMLGADREFIEARRRALKRFVNLVARHPLFSEDVVLKLFLSFSGS
Sbjct: 121 LHKFPYRMVPALPPKRMLGADREFIEARRRALKRFVNLVARHPLFSEDVVLKLFLSFSGS 180
Query: 181 DVQNKLKESAQCVGDEFLNCKLATRAKDFLPADIQAQFAISRELIRNIYNSFHKLRDRAE 240
DVQNKLKESAQCVGDEFLNCKLATRAKDFLPADIQAQFAISRELIRNIYNSFHKLRDRAE
Sbjct: 181 DVQNKLKESAQCVGDEFLNCKLATRAKDFLPADIQAQFAISRELIRNIYNSFHKLRDRAE 240
Query: 241 RIASRAIDNAADLLIFGKELSAIGSDTTPLPSWAALNSSTWGSLKQALKGLSVEFALLAD 300
RIASRAIDNAADLLIFGKELSAIGSDTTPLPSWAALNSSTWGSLKQALKGLSVEFALLAD
Sbjct: 241 RIASRAIDNAADLLIFGKELSAIGSDTTPLPSWAALNSSTWGSLKQALKGLSVEFALLAD 300
Query: 301 KAAQQGKQEENDVVEKLNLFLDLLQSYKDLCERHEKGVLHKHQRALHKYSLMKRQMMSAT 360
KAAQQGKQEENDVVEKLNLFLDLLQSYKDLCERHEKGVLHKHQRALHKYSLMKRQMMSAT
Sbjct: 301 KAAQQGKQEENDVVEKLNLFLDLLQSYKDLCERHEKGVLHKHQRALHKYSLMKRQMMSAT 360
Query: 361 AQNREPESVEQLESRIVEQENAIQTMELRNYFSLYCLHQETQLIHVYLPLTSHILRAFVN 420
AQNREPESVEQLESRIVEQENAIQTMELRNYFSLYCLHQETQLIHVYLPLTSHILRAFVN
Sbjct: 361 AQNREPESVEQLESRIVEQENAIQTMELRNYFSLYCLHQETQLIHVYLPLTSHILRAFVN 420
Query: 421 SQIQGHKEMSKVWNDLRPKLSCLFAGPHSTLTPPCSPPEDGLCPH 465
SQIQGHKEMSKVWNDLRPKLSCLFAGPHSTLTPPCSPPEDGLCPH
Sbjct: 421 SQIQGHKEMSKVWNDLRPKLSCLFAGPHSTLTPPCSPPEDGLCPH 465
>gi|23397574 sorting nexin 33 [Homo sapiens]
Length = 574
Score = 64.3 bits (155), Expect = 2e-10
Identities = 63/257 (24%), Positives = 115/257 (44%), Gaps = 17/257 (6%)
Query: 92 HVEYEVSSQRFKSSVYRRYNDFVVFQEMLLHKFPYRMVPALPPKRMLGA-DREFIEARRR 150
++ Y+++ S VYRRY F LLHKF VP LP K+ G + +FIE R+R
Sbjct: 249 YISYKLTPTHAASPVYRRYKHFDWLYNRLLHKFTVISVPHLPEKQATGRFEEDFIEKRKR 308
Query: 151 ALKRFVNLVARHPLFSEDVVLKLFLSFSGSDVQNKL----KESAQCVGDEF-LNCKLATR 205
L +++ + HP+ S+ + FLS D Q K+ E + VG F L ++ T
Sbjct: 309 RLILWMDHMTSHPVLSQYEGFQHFLSCL-DDKQWKMGKRRAEKDEMVGASFLLTFQIPTE 367
Query: 206 AKDFLPADIQAQFAISRELIRNIYNSFHKLRDRAERIASRAIDNAADLLIFGKELSAIGS 265
+D D++ + + + + +S +L A + + + F KE +GS
Sbjct: 368 HQDL--QDVEDRVDTFKAFSKKMDDSVLQLSTVASELVRKHVGG------FRKEFQKLGS 419
Query: 266 DTTPLPSWAALNSSTWG-SLKQALKGLSVEFALLADKAAQQGKQEENDVVEKLNLFLDLL 324
+ ++ +L A+ + + + A+Q K + +++ L+L+ LL
Sbjct: 420 AFQAISHSFQMDPPFCSEALNSAISHTGRTYEAIGEMFAEQPKNDLFQMLDTLSLYQGLL 479
Query: 325 QSYKDLCERHEKGVLHK 341
++ D+ +KG K
Sbjct: 480 SNFPDIIHL-QKGAFAK 495
>gi|157057545 sorting nexin 18 isoform a [Homo sapiens]
Length = 624
Score = 62.0 bits (149), Expect = 1e-09
Identities = 61/287 (21%), Positives = 120/287 (41%), Gaps = 22/287 (7%)
Query: 92 HVEYEVSSQRFKSSVYRRYNDFVVFQEMLLHKFPYRMVPALPPKRMLGA-DREFIEARRR 150
++ Y++ + V+RRY F L KFP VP LP K+ G + +FI RR+
Sbjct: 295 YISYKLVPTHTQVPVHRRYKHFDWLYARLAEKFPVISVPHLPEKQATGRFEEDFISKRRK 354
Query: 151 ALKRFVNLVARHPLFSEDVVLKLFLSFSGSDVQNKLK------ESAQCVGDEFLNCKLAT 204
L ++N +A HP+ ++ V + FL+ S + K E + VG F
Sbjct: 355 GLIWWMNHMASHPVLAQCDVFQHFLTCPSSTDEKAWKQGKRKAEKDEMVGANFFLTLSTP 414
Query: 205 RAKDFLPADIQAQFAISRELIRNIYNSFHKLRDRAERIASRAIDNAADLLIFGKELSAIG 264
A +++++ + + + +S +L A A + + F KE +G
Sbjct: 415 PAAALDLQEVESKIDGFKCFTKKMDDSALQLNHTANEFARKQVTG------FKKEYQKVG 468
Query: 265 SDTTPLPSWAALNSSTWG-SLKQALKGLSVEFALLADKAAQQGKQEENDVVEKLNLFLDL 323
L L+ + L QA+ + + + A+Q +Q+ + V++ L L+
Sbjct: 469 QSFRGLSQAFELDQQAFSVGLNQAIAFTGDAYDAIGELFAEQPRQDLDPVMDLLALYQGH 528
Query: 324 LQSYKDLCERHEKGVLHKHQRALHKYSLMKRQMMSATAQNREPESVE 370
L ++ D ++H + AL K +R + + ++ + ++
Sbjct: 529 LANFPD--------IIHVQKGALTKVKESRRHVEEGKMEVQKADGIQ 567
Score = 30.0 bits (66), Expect = 4.7
Identities = 22/63 (34%), Positives = 24/63 (38%), Gaps = 9/63 (14%)
Query: 4 RAMDPLPAAAVGAAAEAEADE---------EADPPASDLPTPQAIEPQAIVQQVPAPSRM 54
RA +P PA G A A PPAS P P A + QQ P PS
Sbjct: 60 RAPEPGPAGDGGPGAPARYANVPPGGFEPLPVAPPASFKPPPDAFQALLQPQQAPPPSTF 119
Query: 55 QMP 57
Q P
Sbjct: 120 QPP 122
>gi|4507145 sorting nexin 4 [Homo sapiens]
Length = 450
Score = 61.6 bits (148), Expect = 1e-09
Identities = 65/262 (24%), Positives = 108/262 (41%), Gaps = 44/262 (16%)
Query: 91 KHVEYEVSSQRFKSSVYRRYNDFVVFQEMLLHKFPYRMVPALPPKRM------LGADR-- 142
+ VE+ S++RRY++F + + LL +P+ +VP LP KR L AD
Sbjct: 88 RSVEHTDGQSVLTDSLWRRYSEFELLRSYLLVYYPHIVVPPLPEKRAEFVWHKLSADNMD 147
Query: 143 -EFIEARRRALKRFVNLVARHPLFSEDVVLKLFLSFSGSDVQNKLKESAQCVGDEFLNCK 201
+F+E RR L+ F+ +A HP+ D + LFL+ G+ + + Q D L
Sbjct: 148 PDFVERRRIGLENFLLRIASHPILCRDKIFYLFLTQEGNWKETVNETGFQLKADSRLKAL 207
Query: 202 LAT--------RAKDFLPADIQAQFAISRELIRNIYNSFHKLRDRAERIASRAIDNAADL 253
AT R D + Q IS H LR RA R+A R
Sbjct: 208 NATFRVKNPDKRFTDLKHYSDELQSVIS-----------HLLRVRA-RVADR-------- 247
Query: 254 LIFGKELSAIGSDTTPLPSWAALNSSTWGSLKQALKGLSVEFALLADKAAQQGKQEENDV 313
++G G+ W+A+ L+ A + V + + D ++E
Sbjct: 248 -LYG-VYKVHGNYGRVFSEWSAIEKEMGDGLQSAGHHMDVYASSIDDIL-----EDEEHY 300
Query: 314 VEKLNLFLDLLQSYKDLCERHE 335
++L +L ++ + +C +HE
Sbjct: 301 ADQLKEYLFYAEALRAVCRKHE 322
>gi|23111038 sorting nexin 2 [Homo sapiens]
Length = 519
Score = 61.2 bits (147), Expect = 2e-09
Identities = 89/420 (21%), Positives = 160/420 (38%), Gaps = 83/420 (19%)
Query: 16 AAAEAEADE-EADPPASDLPTPQA--IEPQAIVQQVPAPSRMQMPQGNPLLLSHTLQELL 72
A E D E +P S P+P + P ++ AP P++ + +E+
Sbjct: 77 ATEEVSLDSPEREPILSSEPSPAVTPVTPTTLI----APRIESKSMSAPVIFDRSREEIE 132
Query: 73 AR---DTVQVEL---IPEKKGLFLK-HVEYEVSSQRFKS-------SVYRRYNDFVVFQE 118
D +E+ PEK G + ++ Y V+++ S SV RR++DF+
Sbjct: 133 EEANGDIFDIEIGVSDPEKVGDGMNAYMAYRVTTKTSLSMFSKSEFSVKRRFSDFLGLHS 192
Query: 119 MLLHKFPY--RMVPALPPKRMLGADR-----------EFIEARRRALKRFVNLVARHPLF 165
L K+ + +VP P K ++G + EF+E RR AL+R++ +HP
Sbjct: 193 KLASKYLHVGYIVPPAPEKSIVGMTKVKVGKEDSSSTEFVEKRRAALERYLQRTVKHPTL 252
Query: 166 SEDVVLKLFL------------SFSGSDVQNKLKESAQCVGDEFLNCKLATRAKDFLPAD 213
+D L+ FL + SG+ + + ++A V + +
Sbjct: 253 LQDPDLRQFLESSELPRAVNTQALSGAGILRMVNKAADAVNKMTIKMN-----------E 301
Query: 214 IQAQFAISRELIRNIYNSFHKLRDRAERIASRAIDNAADLLIFGKELSAIGSDTTPLPSW 273
A F ++ N+ KL E + + +A+ F K + +G
Sbjct: 302 SDAWFEEKQQQFENLDQQLRKLHVSVEALVCHRKELSANTAAFAKSAAMLG--------- 352
Query: 274 AALNSSTWGSLKQALKGLSVEFALLADKAAQQGKQEENDVVEKLNLFLDLLQSYKDLCER 333
NS +L +AL + LA+ + + + +F +LL Y L
Sbjct: 353 ---NSEDHTALSRAL-------SQLAEVEEKIDQLHQEQAFADFYMFSELLSDYIRLIAA 402
Query: 334 HEKGVLHKHQRALHKYS------LMKRQMMSATAQNREPESVEQLESRIVEQENAIQTME 387
KGV + K+ L KR+ + +P+ ++Q ++ I E E +Q E
Sbjct: 403 -VKGVFDHRMKCWQKWEDAQITLLKKREAEAKMMVANKPDKIQQAKNEIREWEAKVQQGE 461
>gi|224177511 sorting nexin 18 isoform c [Homo sapiens]
Length = 591
Score = 59.7 bits (143), Expect = 5e-09
Identities = 56/247 (22%), Positives = 105/247 (42%), Gaps = 14/247 (5%)
Query: 92 HVEYEVSSQRFKSSVYRRYNDFVVFQEMLLHKFPYRMVPALPPKRMLGA-DREFIEARRR 150
++ Y++ + V+RRY F L KFP VP LP K+ G + +FI RR+
Sbjct: 295 YISYKLVPTHTQVPVHRRYKHFDWLYARLAEKFPVISVPHLPEKQATGRFEEDFISKRRK 354
Query: 151 ALKRFVNLVARHPLFSEDVVLKLFLSFSGSDVQNKLK------ESAQCVGDEFLNCKLAT 204
L ++N +A HP+ ++ V + FL+ S + K E + VG F
Sbjct: 355 GLIWWMNHMASHPVLAQCDVFQHFLTCPSSTDEKAWKQGKRKAEKDEMVGANFFLTLSTP 414
Query: 205 RAKDFLPADIQAQFAISRELIRNIYNSFHKLRDRAERIASRAIDNAADLLIFGKELSAIG 264
A +++++ + + + +S +L A A + + F KE +G
Sbjct: 415 PAAALDLQEVESKIDGFKCFTKKMDDSALQLNHTANEFARKQVTG------FKKEYQKVG 468
Query: 265 SDTTPLPSWAALNSSTWG-SLKQALKGLSVEFALLADKAAQQGKQEENDVVEKLNLFLDL 323
L L+ + L QA+ + + + A+Q +Q+ + V++ L L+
Sbjct: 469 QSFRGLSQAFELDQQAFSVGLNQAIAFTGDAYDAIGELFAEQPRQDLDPVMDLLALYQGH 528
Query: 324 LQSYKDL 330
L ++ D+
Sbjct: 529 LANFPDI 535
Score = 30.0 bits (66), Expect = 4.7
Identities = 22/63 (34%), Positives = 24/63 (38%), Gaps = 9/63 (14%)
Query: 4 RAMDPLPAAAVGAAAEAEADE---------EADPPASDLPTPQAIEPQAIVQQVPAPSRM 54
RA +P PA G A A PPAS P P A + QQ P PS
Sbjct: 60 RAPEPGPAGDGGPGAPARYANVPPGGFEPLPVAPPASFKPPPDAFQALLQPQQAPPPSTF 119
Query: 55 QMP 57
Q P
Sbjct: 120 QPP 122
>gi|157057543 sorting nexin 18 isoform b [Homo sapiens]
Length = 628
Score = 59.7 bits (143), Expect = 5e-09
Identities = 56/247 (22%), Positives = 105/247 (42%), Gaps = 14/247 (5%)
Query: 92 HVEYEVSSQRFKSSVYRRYNDFVVFQEMLLHKFPYRMVPALPPKRMLGA-DREFIEARRR 150
++ Y++ + V+RRY F L KFP VP LP K+ G + +FI RR+
Sbjct: 295 YISYKLVPTHTQVPVHRRYKHFDWLYARLAEKFPVISVPHLPEKQATGRFEEDFISKRRK 354
Query: 151 ALKRFVNLVARHPLFSEDVVLKLFLSFSGSDVQNKLK------ESAQCVGDEFLNCKLAT 204
L ++N +A HP+ ++ V + FL+ S + K E + VG F
Sbjct: 355 GLIWWMNHMASHPVLAQCDVFQHFLTCPSSTDEKAWKQGKRKAEKDEMVGANFFLTLSTP 414
Query: 205 RAKDFLPADIQAQFAISRELIRNIYNSFHKLRDRAERIASRAIDNAADLLIFGKELSAIG 264
A +++++ + + + +S +L A A + + F KE +G
Sbjct: 415 PAAALDLQEVESKIDGFKCFTKKMDDSALQLNHTANEFARKQVTG------FKKEYQKVG 468
Query: 265 SDTTPLPSWAALNSSTWG-SLKQALKGLSVEFALLADKAAQQGKQEENDVVEKLNLFLDL 323
L L+ + L QA+ + + + A+Q +Q+ + V++ L L+
Sbjct: 469 QSFRGLSQAFELDQQAFSVGLNQAIAFTGDAYDAIGELFAEQPRQDLDPVMDLLALYQGH 528
Query: 324 LQSYKDL 330
L ++ D+
Sbjct: 529 LANFPDI 535
Score = 30.0 bits (66), Expect = 4.7
Identities = 22/63 (34%), Positives = 24/63 (38%), Gaps = 9/63 (14%)
Query: 4 RAMDPLPAAAVGAAAEAEADE---------EADPPASDLPTPQAIEPQAIVQQVPAPSRM 54
RA +P PA G A A PPAS P P A + QQ P PS
Sbjct: 60 RAPEPGPAGDGGPGAPARYANVPPGGFEPLPVAPPASFKPPPDAFQALLQPQQAPPPSTF 119
Query: 55 QMP 57
Q P
Sbjct: 120 QPP 122
>gi|153791707 sorting nexin family member 30 [Homo sapiens]
Length = 437
Score = 57.0 bits (136), Expect = 4e-08
Identities = 70/284 (24%), Positives = 117/284 (41%), Gaps = 44/284 (15%)
Query: 105 SVYRRYNDFVVFQEMLLHKFPYRMVPALPPKRMLGA-----DREFIEARRRALKRFVNLV 159
SV RRY DF + L P ++P LP K ++ EF+E RR+AL +F+ +
Sbjct: 128 SVRRRYQDFDWLRSKLEESQPTHLIPPLPEKFVVKGVVDRFSEEFVETRRKALDKFLKRI 187
Query: 160 ARHPLFSEDVVLKLFLSFSGSDVQNK-----LKESAQCVGDEFLNCKLATRAKDFLPADI 214
HP+ S + +FL+ + K L + V KL TR +F
Sbjct: 188 TDHPVLSFNEHFNIFLTAKDLNAYKKQGIALLTRMGESVKHVTGGYKLRTRPLEF----- 242
Query: 215 QAQFAISRELIRNIYNSFHKLRDRAERIASRAIDNAADLLIFGKELSAIGSDTTPLPSWA 274
I + ++F +RIA R I + L+ +E + S +W+
Sbjct: 243 --------AAIGDYLDTFALKLGTIDRIAQRIIKEEIEYLVELREYGPVYS------TWS 288
Query: 275 ALNSSTWGSLKQALKGLSVEFALLADKAAQQGKQEENDVVEKLNLFLDLLQSYKDLCERH 334
AL G L + L+G+S + ++ +D+ E FL +L+ Y L
Sbjct: 289 ALE----GELAEPLEGVSA----CIGNCSTALEELTDDMTED---FLPVLREY-ILYSDS 336
Query: 335 EKGVLHKHQRALHKYSLMKRQMMSATAQNRE--PESVEQLESRI 376
K VL K + +Y K + ++ ++R P VE+ + R+
Sbjct: 337 MKSVLKKRDQVQAEYE-AKLEAVALRKEDRPKVPADVEKCQDRM 379
>gi|7706706 sorting nexin 9 [Homo sapiens]
Length = 595
Score = 55.1 bits (131), Expect = 1e-07
Identities = 63/267 (23%), Positives = 112/267 (41%), Gaps = 48/267 (17%)
Query: 92 HVEYEVSSQRFKSSVYRRYNDFVVFQEMLLHKFPYRM-VPALPPKRMLGA-DREFIEARR 149
++EY+++ SV RY F E LL KF + +P+LP K++ G + EFI+ R
Sbjct: 269 YIEYQLTPTNTNRSVNHRYKHFDWLYERLLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRM 328
Query: 150 RALKRFVNLVARHPLFSEDVVLKLFLSFSGSDVQNKLKESAQCVGDEFLNCKLATRAKDF 209
L+ ++ + RHP+ SE V + FL+F K A+ DE + + +
Sbjct: 329 ERLQAWMTRMCRHPVISESEVFQQFLNFRDEKEWKTGKRKAE--RDELAGVMIFSTMEPE 386
Query: 210 LPADIQAQFAISRELIRNIYNSFHKLRDRAERIA--SRAIDNAADLLIFGKELSAIGSD- 266
P +L+ ++ + E + ++A+D+ KEL +G +
Sbjct: 387 AP---------DLDLV--------EIEQKCEAVGKFTKAMDDGV------KELLTVGQEH 423
Query: 267 ----TTPLPSWAALNSSTWGSLKQALKGLSVEFALLADKAAQQGKQEENDVVEKLNLFLD 322
T PLP + + +AL+ L+ F+ + QG+ + ND + + +
Sbjct: 424 WKRCTGPLP-------KEYQKIGKALQSLATVFS----SSGYQGETDLNDAITEAGKTYE 472
Query: 323 LLQSYKDLCERHEKGVLHKHQRALHKY 349
+ S L K LH H+Y
Sbjct: 473 EIAS---LVAEQPKKDLHFLMECNHEY 496
>gi|23111055 sorting nexin 7 isoform b [Homo sapiens]
Length = 336
Score = 50.4 bits (119), Expect = 3e-06
Identities = 31/98 (31%), Positives = 52/98 (53%), Gaps = 7/98 (7%)
Query: 96 EVSSQRFKSSVYRRYNDFVVFQEMLLHKFPYRMVPALPPKRMLGA-----DREFIEARRR 150
E S F+ V RRY DF+ + L P ++P LP K ++ + +FIE RR+
Sbjct: 62 EFDSSEFE--VRRRYQDFLWLKGKLEEAHPTLIIPPLPEKFIVKGMVERFNDDFIETRRK 119
Query: 151 ALKRFVNLVARHPLFSEDVVLKLFLSFSGSDVQNKLKE 188
AL +F+N +A HP + + K+FL+ ++ + K+
Sbjct: 120 ALHKFLNRIADHPTLTFNEDFKIFLTAQAWELSSHKKQ 157
>gi|194294540 sorting nexin 7 isoform a [Homo sapiens]
Length = 451
Score = 50.4 bits (119), Expect = 3e-06
Identities = 31/98 (31%), Positives = 52/98 (53%), Gaps = 7/98 (7%)
Query: 96 EVSSQRFKSSVYRRYNDFVVFQEMLLHKFPYRMVPALPPKRMLGA-----DREFIEARRR 150
E S F+ V RRY DF+ + L P ++P LP K ++ + +FIE RR+
Sbjct: 126 EFDSSEFE--VRRRYQDFLWLKGKLEEAHPTLIIPPLPEKFIVKGMVERFNDDFIETRRK 183
Query: 151 ALKRFVNLVARHPLFSEDVVLKLFLSFSGSDVQNKLKE 188
AL +F+N +A HP + + K+FL+ ++ + K+
Sbjct: 184 ALHKFLNRIADHPTLTFNEDFKIFLTAQAWELSSHKKQ 221
>gi|23111032 sorting nexin 1 isoform b [Homo sapiens]
Length = 457
Score = 49.3 bits (116), Expect = 7e-06
Identities = 95/425 (22%), Positives = 170/425 (40%), Gaps = 77/425 (18%)
Query: 5 AMDPLPAAAVGAAAEAE-ADEEADPPASDLPTPQAIEPQAIVQQVPAPSRMQMPQGNPLL 63
A + LP G E+E A ++P A D T E + I S+ Q P+ L
Sbjct: 10 ASERLPPPFPGLEPESEGAAGGSEPEAGDSDT----EGEDIFTGAAVVSKHQSPKITTSL 65
Query: 64 LSHTLQELLARDTVQVELIPEKKGLFL-----KHVEYEVSSQR----FKS---SVYRRYN 111
L + + + E E + LF +V Y+V++Q F+S +V RR++
Sbjct: 66 LP--INNGSKENGIHEEQDQEPQDLFAGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFS 123
Query: 112 DFVVFQEMLLHKFPYR--MVPALPPKRMLGADR-----------EFIEARRRALKRFVNL 158
DF+ E L K +VP P K ++G + EF+E RR AL+R++
Sbjct: 124 DFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQR 183
Query: 159 VARHPLFSEDVVLKLFLSFSGSDVQNKLKESAQCVGDEFLN----CKLATRAKDFLPA-- 212
+ HP +D ++ FL + +E + VG + L+ K+ +A D +
Sbjct: 184 IVNHPTMLQDPDVREFL---------EKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMT 234
Query: 213 ----DIQAQFAISRELIRNIYNSFHKLRDRAERIASRAIDNAADLLIFGKELSAIGSDTT 268
+ F + + KL E + + + A + F K L+ +GS
Sbjct: 235 IKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGS--- 291
Query: 269 PLPSWAALNSSTWGSLKQALKGLSVEFALLADKAAQQGKQEEND----VVEKLNLFLDLL 324
S +L +AL + A + +K Q +++ N+ + E L+ ++ LL
Sbjct: 292 ---------SEDNTALSRALS----QLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLL 338
Query: 325 QSYKDLCERHEK--GVLHKHQRALHKYSLMKRQMMSATAQNREPESVEQLESRIVEQENA 382
+ ++ K Q L K KR+ + +P+ ++Q + I+E E+
Sbjct: 339 AIVRAAFDQRMKTWQRWQDAQATLQK----KREAEARLLWANKPDKLQQAKDEILEWESR 394
Query: 383 IQTME 387
+ E
Sbjct: 395 VTQYE 399
>gi|31543452 PX domain containing serine/threonine kinase [Homo
sapiens]
Length = 578
Score = 49.3 bits (116), Expect = 7e-06
Identities = 35/112 (31%), Positives = 58/112 (51%), Gaps = 9/112 (8%)
Query: 70 ELLARDTVQVELIPEKKGLFLKHVEYEVSSQRFKS-----SVYRRYNDFVVFQEMLLHKF 124
++L DTV + E H EY + QR S + RRY+DF + L +
Sbjct: 11 KVLLDDTVPLTAAIEASQSLQSHTEYIIRVQRGISVENSWQIVRRYSDFDLLNNSL--QI 68
Query: 125 PYRMVPALPPKRMLG-ADREFIEARRRALKRFVNLVARHPLFSEDVVLKLFL 175
+P LPPK+++G DREFI R++ L+ ++N++ + + S ++K FL
Sbjct: 69 AGLSLP-LPPKKLIGNMDREFIAERQKGLQNYLNVITTNHILSNCELVKKFL 119
>gi|23111034 sorting nexin 1 isoform a [Homo sapiens]
Length = 522
Score = 47.8 bits (112), Expect = 2e-05
Identities = 77/342 (22%), Positives = 142/342 (41%), Gaps = 66/342 (19%)
Query: 83 PEKKGLFLK-HVEYEVSSQR----FKS---SVYRRYNDFVVFQEMLLHKFPYR--MVPAL 132
PEK G + +V Y+V++Q F+S +V RR++DF+ E L K +VP
Sbjct: 152 PEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPP 211
Query: 133 PPKRMLGADR-----------EFIEARRRALKRFVNLVARHPLFSEDVVLKLFLSFSGSD 181
P K ++G + EF+E RR AL+R++ + HP +D ++ FL
Sbjct: 212 PEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFL------ 265
Query: 182 VQNKLKESAQCVGDEFLN----CKLATRAKDFLPA------DIQAQFAISRELIRNIYNS 231
+ +E + VG + L+ K+ +A D + + F + +
Sbjct: 266 ---EKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQR 322
Query: 232 FHKLRDRAERIASRAIDNAADLLIFGKELSAIGSDTTPLPSWAALNSSTWGSLKQALKGL 291
KL E + + + A + F K L+ +GS S +L +AL
Sbjct: 323 LRKLHAVVETLVNHRKELALNTAQFAKSLAMLGS------------SEDNTALSRALS-- 368
Query: 292 SVEFALLADKAAQQGKQEEND----VVEKLNLFLDLLQSYKDLCERHEK--GVLHKHQRA 345
+ A + +K Q +++ N+ + E L+ ++ LL + ++ K Q
Sbjct: 369 --QLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQAT 426
Query: 346 LHKYSLMKRQMMSATAQNREPESVEQLESRIVEQENAIQTME 387
L K KR+ + +P+ ++Q + I+E E+ + E
Sbjct: 427 LQK----KREAEARLLWANKPDKLQQAKDEILEWESRVTQYE 464
>gi|23111036 sorting nexin 1 isoform c [Homo sapiens]
Length = 474
Score = 45.4 bits (106), Expect = 1e-04
Identities = 36/114 (31%), Positives = 58/114 (50%), Gaps = 21/114 (18%)
Query: 83 PEKKGLFLK-HVEYEVSSQR----FKS---SVYRRYNDFVVFQEMLLHKFPYR--MVPAL 132
PEK G + +V Y+V++Q F+S +V RR++DF+ E L K +VP
Sbjct: 152 PEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPP 211
Query: 133 PPKRMLGADR-----------EFIEARRRALKRFVNLVARHPLFSEDVVLKLFL 175
P K ++G + EF+E RR AL+R++ + HP +D ++ FL
Sbjct: 212 PEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFL 265
>gi|24797143 sorting nexin 14 isoform b [Homo sapiens]
Length = 893
Score = 44.7 bits (104), Expect = 2e-04
Identities = 26/80 (32%), Positives = 42/80 (52%), Gaps = 1/80 (1%)
Query: 105 SVYRRYNDFVVFQEMLLHKFPYRMVPALPPKRMLGADR-EFIEARRRALKRFVNLVARHP 163
SVYRRY +F V + L LP KR++G EF++++R + ++ + +HP
Sbjct: 559 SVYRRYLEFYVLESKLTEFHGAFPDAQLPSKRIIGPKNYEFLKSKREEFQEYLQKLLQHP 618
Query: 164 LFSEDVVLKLFLSFSGSDVQ 183
S +L FLS +G + Q
Sbjct: 619 ELSNSQLLADFLSPNGGETQ 638
>gi|24797145 sorting nexin 14 isoform a [Homo sapiens]
Length = 946
Score = 44.7 bits (104), Expect = 2e-04
Identities = 26/80 (32%), Positives = 42/80 (52%), Gaps = 1/80 (1%)
Query: 105 SVYRRYNDFVVFQEMLLHKFPYRMVPALPPKRMLGADR-EFIEARRRALKRFVNLVARHP 163
SVYRRY +F V + L LP KR++G EF++++R + ++ + +HP
Sbjct: 612 SVYRRYLEFYVLESKLTEFHGAFPDAQLPSKRIIGPKNYEFLKSKREEFQEYLQKLLQHP 671
Query: 164 LFSEDVVLKLFLSFSGSDVQ 183
S +L FLS +G + Q
Sbjct: 672 ELSNSQLLADFLSPNGGETQ 691
>gi|23111026 sorting nexin 11 [Homo sapiens]
Length = 270
Score = 44.7 bits (104), Expect = 2e-04
Identities = 33/100 (33%), Positives = 50/100 (50%), Gaps = 8/100 (8%)
Query: 84 EKKGLFLKHVEYEV----SSQRFK---SSVYRRYNDFVVFQEMLLHKFPYRMVPALPPKR 136
+ +G + +V+Y++ +S+ F S V RRY +FV ++ L VP LP K
Sbjct: 27 QNEGSWNSYVDYKIFLHTNSKAFTAKTSCVRRRYREFVWLRKQLQRNAGLVPVPELPGKS 86
Query: 137 -MLGADREFIEARRRALKRFVNLVARHPLFSEDVVLKLFL 175
G EFIE RR+ L+ F+ V + + D L LFL
Sbjct: 87 TFFGTSDEFIEKRRQGLQHFLEKVLQSVVLLSDSQLHLFL 126
>gi|23111028 sorting nexin 11 [Homo sapiens]
Length = 270
Score = 44.7 bits (104), Expect = 2e-04
Identities = 33/100 (33%), Positives = 50/100 (50%), Gaps = 8/100 (8%)
Query: 84 EKKGLFLKHVEYEV----SSQRFK---SSVYRRYNDFVVFQEMLLHKFPYRMVPALPPKR 136
+ +G + +V+Y++ +S+ F S V RRY +FV ++ L VP LP K
Sbjct: 27 QNEGSWNSYVDYKIFLHTNSKAFTAKTSCVRRRYREFVWLRKQLQRNAGLVPVPELPGKS 86
Query: 137 -MLGADREFIEARRRALKRFVNLVARHPLFSEDVVLKLFL 175
G EFIE RR+ L+ F+ V + + D L LFL
Sbjct: 87 TFFGTSDEFIEKRRQGLQHFLEKVLQSVVLLSDSQLHLFL 126
>gi|4507143 sorting nexin 3 isoform a [Homo sapiens]
Length = 162
Score = 44.3 bits (103), Expect = 2e-04
Identities = 30/83 (36%), Positives = 43/83 (51%), Gaps = 11/83 (13%)
Query: 103 KSSVYRRYNDFVVFQEMLLHKFPYRMVPALPPKRMLGA----------DREFIEARRRAL 152
+S+V RRY+DF + L + +VP LP K L D FIE R++ L
Sbjct: 64 ESTVRRRYSDFEWLRSELERESKV-VVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGL 122
Query: 153 KRFVNLVARHPLFSEDVVLKLFL 175
++F+N VA HPL + L +FL
Sbjct: 123 EQFINKVAGHPLAQNERCLHMFL 145
>gi|23111030 sorting nexin 12 [Homo sapiens]
Length = 162
Score = 42.0 bits (97), Expect = 0.001
Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 11/89 (12%)
Query: 103 KSSVYRRYNDFVVFQEMLLHKFPYRMVPALPPKRMLGA----------DREFIEARRRAL 152
+S V RRY+DF + L + +VP LP K + + FIE RR+ L
Sbjct: 65 ESCVRRRYSDFEWLKNEL-ERDSKIVVPPLPGKALKRQLPFRGDEGIFEESFIEERRQGL 123
Query: 153 KRFVNLVARHPLFSEDVVLKLFLSFSGSD 181
++F+N +A HPL + L +FL D
Sbjct: 124 EQFINKIAGHPLAQNERCLHMFLQEEAID 152
>gi|154091028 sorting nexin 29 [Homo sapiens]
Length = 428
Score = 40.8 bits (94), Expect = 0.003
Identities = 19/56 (33%), Positives = 32/56 (57%), Gaps = 1/56 (1%)
Query: 105 SVYRRYNDFVVFQEMLLHKFPYRMVPALPPKRMLG-ADREFIEARRRALKRFVNLV 159
++YRRY +F L +K+P PPK+ +G D +F+E RR+ L+ ++ V
Sbjct: 305 NIYRRYTEFRSLHHKLQNKYPQVRAYNFPPKKAIGNKDAKFVEERRKQLQNYLRSV 360
>gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [Homo
sapiens]
Length = 464
Score = 40.4 bits (93), Expect = 0.003
Identities = 33/107 (30%), Positives = 49/107 (45%), Gaps = 4/107 (3%)
Query: 84 EKKGLFLKHVEYEVSSQRFKSSVYRRYNDFVVFQEMLLHKFPYRMVPALPPKRMLGA--D 141
EKK F + + VS R + V+RRY +F L +FP M +P KR+ G D
Sbjct: 26 EKKKRFTVY-KVLVSVGRSEWFVFRRYAEFDKLYNTLKKQFP-AMALKIPAKRIFGDNFD 83
Query: 142 REFIEARRRALKRFVNLVARHPLFSEDVVLKLFLSFSGSDVQNKLKE 188
+FI+ RR L F+ + R+P ++ FL Q+ E
Sbjct: 84 PDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSE 130
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 40.4 bits (93), Expect = 0.003
Identities = 33/107 (30%), Positives = 49/107 (45%), Gaps = 4/107 (3%)
Query: 84 EKKGLFLKHVEYEVSSQRFKSSVYRRYNDFVVFQEMLLHKFPYRMVPALPPKRMLGA--D 141
EKK F + + VS R + V+RRY +F L +FP M +P KR+ G D
Sbjct: 26 EKKKRFTVY-KVLVSVGRSEWFVFRRYAEFDKLYNTLKKQFP-AMALKIPAKRIFGDNFD 83
Query: 142 REFIEARRRALKRFVNLVARHPLFSEDVVLKLFLSFSGSDVQNKLKE 188
+FI+ RR L F+ + R+P ++ FL Q+ E
Sbjct: 84 PDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSE 130
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 40.4 bits (93), Expect = 0.003
Identities = 33/107 (30%), Positives = 49/107 (45%), Gaps = 4/107 (3%)
Query: 84 EKKGLFLKHVEYEVSSQRFKSSVYRRYNDFVVFQEMLLHKFPYRMVPALPPKRMLGA--D 141
EKK F + + VS R + V+RRY +F L +FP M +P KR+ G D
Sbjct: 26 EKKKRFTVY-KVLVSVGRSEWFVFRRYAEFDKLYNTLKKQFP-AMALKIPAKRIFGDNFD 83
Query: 142 REFIEARRRALKRFVNLVARHPLFSEDVVLKLFLSFSGSDVQNKLKE 188
+FI+ RR L F+ + R+P ++ FL Q+ E
Sbjct: 84 PDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSE 130
>gi|7661890 sorting nexin 17 [Homo sapiens]
Length = 470
Score = 40.4 bits (93), Expect = 0.003
Identities = 19/75 (25%), Positives = 35/75 (46%)
Query: 109 RYNDFVVFQEMLLHKFPYRMVPALPPKRMLGADREFIEARRRALKRFVNLVARHPLFSED 168
RY+ + E L ++ ++PA PPK++ +E RR L++++ V + PL
Sbjct: 36 RYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSS 95
Query: 169 VVLKLFLSFSGSDVQ 183
FL + + Q
Sbjct: 96 ETFNSFLRRAQQETQ 110
>gi|23111023 sorting nexin 10 [Homo sapiens]
Length = 201
Score = 39.7 bits (91), Expect = 0.006
Identities = 29/101 (28%), Positives = 51/101 (50%), Gaps = 9/101 (8%)
Query: 84 EKKGLFLKHVEYEV----SSQRFK---SSVYRRYNDFVVFQEMLLHKFPYRMVPALPPKR 136
+K+ + +++YE+ +S F S V RRY +FV ++ L +P LP K
Sbjct: 21 QKEDFWHSYIDYEICIHTNSMCFTMKTSCVRRRYREFVWLRQRLQSNALLVQLPELPSKN 80
Query: 137 MLGA--DREFIEARRRALKRFVNLVARHPLFSEDVVLKLFL 175
+ +R+ ++ RR+ L+ F+ V ++ L D L LFL
Sbjct: 81 LFFNMNNRQHVDQRRQGLEDFLRKVLQNALLLSDSSLHLFL 121
>gi|31742501 sorting nexin family member 27 [Homo sapiens]
Length = 528
Score = 38.5 bits (88), Expect = 0.013
Identities = 20/71 (28%), Positives = 35/71 (49%)
Query: 108 RRYNDFVVFQEMLLHKFPYRMVPALPPKRMLGADREFIEARRRALKRFVNLVARHPLFSE 167
+RY +F + + L +F P LP K + ++ARRR L+ ++ V + E
Sbjct: 195 KRYREFAILHQNLKREFANFTFPRLPGKWPFSLSEQQLDARRRGLEEYLEKVCSIRVIGE 254
Query: 168 DVVLKLFLSFS 178
+++ FLS S
Sbjct: 255 SDIMQEFLSES 265
>gi|23238244 sorting nexin 16 isoform a [Homo sapiens]
Length = 344
Score = 37.7 bits (86), Expect = 0.022
Identities = 30/99 (30%), Positives = 46/99 (46%), Gaps = 20/99 (20%)
Query: 95 YEVSSQRFKSSVY---------------RRYNDFVVFQEMLLHKFP-YRMVPALPPKRML 138
YEV +R K +VY RRY DF + L FP +R+ ALPPKR
Sbjct: 115 YEVMEERAKFTVYKILVKKTPEESWVVFRRYTDFSRLNDKLKEMFPGFRL--ALPPKRWF 172
Query: 139 --GADREFIEARRRALKRFVNLVARHPLFSEDVVLKLFL 175
+ +F+E R+ L+ F+ + H + + ++ FL
Sbjct: 173 KDNYNADFLEDRQLGLQAFLQNLVAHKDIANCLAVREFL 211
>gi|23238246 sorting nexin 16 isoform a [Homo sapiens]
Length = 344
Score = 37.7 bits (86), Expect = 0.022
Identities = 30/99 (30%), Positives = 46/99 (46%), Gaps = 20/99 (20%)
Query: 95 YEVSSQRFKSSVY---------------RRYNDFVVFQEMLLHKFP-YRMVPALPPKRML 138
YEV +R K +VY RRY DF + L FP +R+ ALPPKR
Sbjct: 115 YEVMEERAKFTVYKILVKKTPEESWVVFRRYTDFSRLNDKLKEMFPGFRL--ALPPKRWF 172
Query: 139 --GADREFIEARRRALKRFVNLVARHPLFSEDVVLKLFL 175
+ +F+E R+ L+ F+ + H + + ++ FL
Sbjct: 173 KDNYNADFLEDRQLGLQAFLQNLVAHKDIANCLAVREFL 211
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,571,386
Number of Sequences: 37866
Number of extensions: 793043
Number of successful extensions: 4252
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 70
Number of HSP's that attempted gapping in prelim test: 4107
Number of HSP's gapped (non-prelim): 192
length of query: 465
length of database: 18,247,518
effective HSP length: 106
effective length of query: 359
effective length of database: 14,233,722
effective search space: 5109906198
effective search space used: 5109906198
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.