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Search of human proteins with 237858619
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|237858619 polyamine modulated factor 1 binding protein 1
isoform a [Homo sapiens]
(1007 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|237858619 polyamine modulated factor 1 binding protein 1 isof... 1975 0.0
gi|237858621 polyamine modulated factor 1 binding protein 1 isof... 1679 0.0
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 151 3e-36
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 149 1e-35
gi|21735548 centrosomal protein 2 [Homo sapiens] 144 5e-34
gi|55770834 centromere protein F [Homo sapiens] 141 4e-33
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 138 3e-32
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 137 5e-32
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 137 5e-32
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 137 5e-32
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 137 5e-32
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 137 7e-32
gi|71061468 centromere protein E [Homo sapiens] 135 1e-31
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 135 2e-31
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 134 3e-31
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 134 3e-31
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 134 4e-31
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 134 6e-31
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 133 7e-31
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 133 1e-30
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 133 1e-30
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 129 1e-29
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 129 1e-29
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 129 1e-29
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 129 1e-29
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 129 2e-29
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 129 2e-29
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 127 5e-29
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 126 9e-29
gi|118498368 kinectin 1 isoform c [Homo sapiens] 126 9e-29
>gi|237858619 polyamine modulated factor 1 binding protein 1 isoform a
[Homo sapiens]
Length = 1007
Score = 1975 bits (5116), Expect = 0.0
Identities = 1007/1007 (100%), Positives = 1007/1007 (100%)
Query: 1 MKDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQA 60
MKDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQA
Sbjct: 1 MKDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQA 60
Query: 61 QALAFEESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEK 120
QALAFEESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEK
Sbjct: 61 QALAFEESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEK 120
Query: 121 QTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNL 180
QTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNL
Sbjct: 121 QTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNL 180
Query: 181 YRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQK 240
YRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQK
Sbjct: 181 YRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQK 240
Query: 241 RLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEE 300
RLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEE
Sbjct: 241 RLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEE 300
Query: 301 CEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGL 360
CEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGL
Sbjct: 301 CEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGL 360
Query: 361 REETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQV 420
REETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQV
Sbjct: 361 REETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQV 420
Query: 421 QNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQER 480
QNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQER
Sbjct: 421 QNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQER 480
Query: 481 LAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEK 540
LAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEK
Sbjct: 481 LAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEK 540
Query: 541 EQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGS 600
EQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGS
Sbjct: 541 EQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGS 600
Query: 601 IKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEE 660
IKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEE
Sbjct: 601 IKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEE 660
Query: 661 ENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKH 720
ENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKH
Sbjct: 661 ENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKH 720
Query: 721 YLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEI 780
YLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEI
Sbjct: 721 YLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEI 780
Query: 781 IAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKE 840
IAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKE
Sbjct: 781 IAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKE 840
Query: 841 EQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVA 900
EQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVA
Sbjct: 841 EQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVA 900
Query: 901 NEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKAL 960
NEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKAL
Sbjct: 901 NEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKAL 960
Query: 961 GPSRTESTQREKVCGTLGWKGLPQDMGQRMDLTKYIGMPHCPGSSYC 1007
GPSRTESTQREKVCGTLGWKGLPQDMGQRMDLTKYIGMPHCPGSSYC
Sbjct: 961 GPSRTESTQREKVCGTLGWKGLPQDMGQRMDLTKYIGMPHCPGSSYC 1007
>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform b
[Homo sapiens]
Length = 882
Score = 1679 bits (4349), Expect = 0.0
Identities = 862/882 (97%), Positives = 862/882 (97%), Gaps = 20/882 (2%)
Query: 146 MGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGE 205
MGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGE
Sbjct: 1 MGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGE 60
Query: 206 LGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLAC 265
LGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLAC
Sbjct: 61 LGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLAC 120
Query: 266 SNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEY 325
SNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEY
Sbjct: 121 SNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEY 180
Query: 326 QNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQEL 385
QNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQEL
Sbjct: 181 QNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQEL 240
Query: 386 QLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTV 445
QLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTV
Sbjct: 241 QLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTV 300
Query: 446 KEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQR 505
KEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQR
Sbjct: 301 KEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQR 360
Query: 506 KLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLEN 565
KLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLEN
Sbjct: 361 KLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLEN 420
Query: 566 SDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKK 625
SDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKK
Sbjct: 421 SDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKK 480
Query: 626 SKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNT 685
SKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNT
Sbjct: 481 SKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNT 540
Query: 686 SQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDL 745
SQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDL
Sbjct: 541 SQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDL 600
Query: 746 TQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESE 805
TQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESE
Sbjct: 601 TQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESE 660
Query: 806 LEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPC 865
LEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPC
Sbjct: 661 LEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPC 720
Query: 866 CLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKD-- 923
CLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKD
Sbjct: 721 CLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDRE 780
Query: 924 ------------------HLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRT 965
HLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRT
Sbjct: 781 PTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRT 840
Query: 966 ESTQREKVCGTLGWKGLPQDMGQRMDLTKYIGMPHCPGSSYC 1007
ESTQREKVCGTLGWKGLPQDMGQRMDLTKYIGMPHCPGSSYC
Sbjct: 841 ESTQREKVCGTLGWKGLPQDMGQRMDLTKYIGMPHCPGSSYC 882
Score = 82.0 bits (201), Expect = 3e-15
Identities = 124/677 (18%), Positives = 274/677 (40%), Gaps = 91/677 (13%)
Query: 8 RDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEE 67
+D++++ L +L LQL+ + ++ K LQ+
Sbjct: 226 KDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKD----------------------- 262
Query: 68 SEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVL 127
LQ+L+KKL +Q L +EL+ + + +++ D
Sbjct: 263 -------------EMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQD-KS 308
Query: 128 LHHHCKLKEDEVILYE---EEMGNHNENTGEKLHLAQEQLALAGDKIASLERSL--NLYR 182
CK + EV + EE ++ +E+ ALAG + +R L L
Sbjct: 309 KEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLL 368
Query: 183 DKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRL 242
DK ++ I+ L+ +++MLQ E ++ N+ ++ + S +++ + + K
Sbjct: 369 DKQKA--DTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEA-LRKLENSDKEK 425
Query: 243 SEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECE 302
++ + V++QD + ++ +++ + RE+ IK + + E+ +
Sbjct: 426 RQLQKTVAEQDMKMNDMLDRIKHQH-----REQGSIKCKLE---------------EDLQ 465
Query: 303 DIKKILKHLQEQ----KDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLH 358
+ K+L+ +EQ K+ + L E + L ++ + + + + E R + ++ L +L
Sbjct: 466 EATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQ 525
Query: 359 GLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQ------- 411
+ + + + + ++Q +E+ L+ L + DK LQ++ LQ
Sbjct: 526 CCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEA 585
Query: 412 --ELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSK-EAECKALQAEVQKL 468
L +K Q+ L + ++L L+ ++ + ++ K++ E E A + ++KL
Sbjct: 586 YDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKL 645
Query: 469 KNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQREL 528
L + + + + + ++ C + Q++ Q L + K + ++E Q E+
Sbjct: 646 NTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEM 705
Query: 529 QMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDML 588
L++ +KE + + S+ + R +D+ L++ +Q +
Sbjct: 706 AALKENLLEDDKEPCC----LPQWSVP-KDTCRLYRGNDQIMTNLEQWAKQQKVAN---- 756
Query: 589 DRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKD 648
+++ +Q REQ KL + S H L + L+QE KK
Sbjct: 757 EKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRPSSPSHSHL-HSVMVHLQQENKKLK 815
Query: 649 KTLKENSRKLEEENENL 665
K ++E +K++ EN L
Sbjct: 816 KEIEE--KKMKAENTRL 830
Score = 76.3 bits (186), Expect = 1e-13
Identities = 121/594 (20%), Positives = 247/594 (41%), Gaps = 87/594 (14%)
Query: 7 ERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFE 66
++++E+ L++ +K K + + Q +++ NS + KQ + LA +
Sbjct: 281 KKEKELEKQQCMATELEMTVKEAKQD-KSKEAECKALQAEVQKLKNSLEEAKQQERLAAQ 339
Query: 67 ESEV--EFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEK-QTS 123
++ E + CHL Q+ +K L+L ++ +ELQ L++ S+ EK QTS
Sbjct: 340 QAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTS 399
Query: 124 DLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIAS-LERSLNLYR 182
+ + + +E+ L E EN+ ++ Q+ +A K+ L+R + +R
Sbjct: 400 N--------RKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHR 451
Query: 183 DKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRL 242
++ E L+ K+L+ + ++ + +H K+ + QE ++ K L
Sbjct: 452 EQGSIKCKLEEDLQEATKLLEDK-----REQLKKSKEHEKLMEGELEALRQEFKKKDKTL 506
Query: 243 SEVWQKVSQQDD-------------------------LIQELRNKLACSN----ALVLER 273
E +K+ ++++ +IQ+L ++A +L +
Sbjct: 507 KENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQL 566
Query: 274 EKALIKLQADFASCTATHRYPPSS--SEECED----IKKILKHLQEQKDSQCLHVEEYQN 327
+KAL K + + Y S S C+D + L H+ + S + + Q
Sbjct: 567 DKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQE 626
Query: 328 LVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQL 387
L E+ A E+ + + ++ K L G +E+ + DK +L+E+
Sbjct: 627 KKAQLEEEIIAYEERMKKLNTELRK----LRGFHQESELEVHAFDK-------KLEEMSC 675
Query: 388 EFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKE--------LEKQQC--- 436
+ + QK K L K+E L+E ++++ ++ +LL+ +KE + K C
Sbjct: 676 QVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLY 735
Query: 437 -----MATELEMTVKEAKQDKSKEAECKALQAEVQKL-KNSLEEAKQQERLAA----QQA 486
+ T LE K+ K K L+ +V+ + K S E+ ++ R ++ + +
Sbjct: 736 RGNDQIMTNLEQWAKQQKVANEKLG--NQLREQVKYIAKLSGEKDREPTRASSPNTTRPS 793
Query: 487 AQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEK 540
+ HL+ +KL+K + K KA+ + + L + ES+ EK
Sbjct: 794 SPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRTESTQREK 847
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 151 bits (382), Expect = 3e-36
Identities = 219/1005 (21%), Positives = 441/1005 (43%), Gaps = 142/1005 (14%)
Query: 11 EVSSLNSKLLSLQLDIKNLHDVCKRQR-----KTLQDNQLCMEEAMNSSHDKKQAQALAF 65
E++ L+SKLL + + H K QR K + Q + + S ++Q +
Sbjct: 415 EINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVT 474
Query: 66 EESEVE--FGSSKQCHLRQL---QQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEK 120
+E++ +KQ H Q Q KL Q +LE ++ ++ +++L+K
Sbjct: 475 NSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQK 534
Query: 121 QTSDLVLLHHHCKLKEDEVILYEEEMGNHNENT-----GEKLHLAQEQLALAGDKIASLE 175
++ LL K +ED LY + E EK H QEQ+ +K+ +
Sbjct: 535 SKENISLLE---KERED---LYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQS 588
Query: 176 RSL-----NLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPC 230
S NL+ D+ Q +++ + +V L+ + + Q E+K S++ I
Sbjct: 589 ESHKQAQENLH-DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDI----- 642
Query: 231 MIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTAT 290
Q +T+ LS K +Q+ DL +N L + + ++++ L K+ TA
Sbjct: 643 --QIKAKTELLLSAEAAKTAQRADL----QNHLDTAQNALQDKQQELNKITTQLDQVTAK 696
Query: 291 HRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLR---VELEAVSEQKRNIM 347
+ E C ++ LK +E+ S EE + +K L +E++A EQ +
Sbjct: 697 LQ---DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDL 753
Query: 348 KDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKD 407
+ +L DL E S +E ++ E + +L L+K K
Sbjct: 754 QQQRQLNTDLELRATELSKQLE---------------MEKEIVSSTRLDLQK------KS 792
Query: 408 EMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQK 467
E L+ +++KLT K+ E++Q + + E +E K + + L +Q
Sbjct: 793 EALESIKQKLT----------KQEEEKQILKQDFETLSQETK------IQHEELNNRIQT 836
Query: 468 LKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQK------GLLLDKQKADTI 521
L++ K ++ + + K++ + L++++ + +K +LD +K T
Sbjct: 837 TVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEK--TC 894
Query: 522 QELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQD 581
+EL+ +LQ+ + + +KE + ++ +E S +L KLE + +++ +Q A+
Sbjct: 895 KELKHQLQVQMENTLKEQKELKKSLEKEKEASHQL-----KLELNSMQEQLIQ---AQNT 946
Query: 582 MKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLK----KSKEHEKLMEGEL 637
+K N+ K + + QG+I +L++ ++ K +E + +LK + E E ++ +L
Sbjct: 947 LKQNE-----KEEQQLQGNIN-ELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQL 1000
Query: 638 EALRQEF---KKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLN 694
QE K+K L+ N K +E + L+++ ++L ++ +Q ++ +
Sbjct: 1001 TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLAT-------RQDLKSVE 1053
Query: 695 KEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNH 754
++++L +E L+S + Q+ + +Q T +A L + SA + L + + L
Sbjct: 1054 EKLSLAQEDLISNRNQIGN----QNKLIQELKTAKA--TLEQDSAKKEQQLQERCKALQD 1107
Query: 755 VTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELR--KLRGFHQESEL---EVH 809
+ E ++ L + K A++EE E+ + KLN EL+ KL + + L +
Sbjct: 1108 IQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQL 1167
Query: 810 AFDKKLE-----EMSCQVLQWQKQHQNDLKMLAAKEEQ--LREFQEEMAALKENLLEDDK 862
+KLE + ++ +K++Q LK KEE+ +EF E+ A L + E +
Sbjct: 1168 LIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKE- 1226
Query: 863 EPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVAN--EKLGNQLREQVKYI-AKLS 919
+ + K T ++ N+ + T ++W Q+ + EK + LR ++ + A +
Sbjct: 1227 VGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQ 1286
Query: 920 GEKDHLHSVMVHL---QQENKKLKKEIEEKKMKAENTRLCTKALG 961
+D +++ + E +KL+ ++ E + K +NT + LG
Sbjct: 1287 NNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELG 1331
Score = 134 bits (337), Expect = 4e-31
Identities = 200/994 (20%), Positives = 414/994 (41%), Gaps = 131/994 (13%)
Query: 11 EVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEESEV 70
+V+ L +L+ +Q + N+ +R+ + L+D C + + S + +A
Sbjct: 222 DVAVLKKELVQVQTLMDNMTLERERESEKLKDE--CKK--LQSQYASSEATISQLRSELA 277
Query: 71 EFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLHH 130
+ ++++LQ+LK + L Q+ + TE L + Y + EK + V
Sbjct: 278 KGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKE---QDYTKLEEKHNEESV---- 330
Query: 131 HCKLKEDEVILYEEEMG-----NHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKY 185
K + L+++++ + + LH +L+ G+ L+ L+ KY
Sbjct: 331 --SKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKY 388
Query: 186 QSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEV 245
Q L+ + K LQ Q+ E K H + + ET+++L E
Sbjct: 389 QH-------LKAEFKQLQ--------QQREEKEQHGLQLQSEINQLHSKLLETERQLGEA 433
Query: 246 WQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIK 305
++ +Q L S+ ++++E+ + LQ + + ++S E
Sbjct: 434 HGRLKEQRQL----------SSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTE----- 478
Query: 306 KILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETS 365
LQ Q D +E Q L + +L +++ + + + L
Sbjct: 479 -----LQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLE---- 529
Query: 366 AHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLL 425
A +++ ++I++L+ ++L + + T ++ LQEK+ LQE +LT+ L
Sbjct: 530 ALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ-LQEKNHTLQEQVTQLTEK----L 584
Query: 426 KKEKELEKQQCMATELEMTVKEAKQD-KSKEAECKALQAEVQKLKNSLEEAKQQ------ 478
K + E KQ L V+E K ++ + +L+ V +L + L E+K++
Sbjct: 585 KNQSESHKQA--QENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDI 642
Query: 479 ------ERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQK-----ADTIQELQRE 527
E L + +AA+ + A L HL+ Q LQ DKQ+ + ++ +
Sbjct: 643 QIKAKTELLLSAEAAKTAQRADLQN-HLDTAQNALQ-----DKQQELNKITTQLDQVTAK 696
Query: 528 LQMLQKESSMAE---KEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKM 584
LQ Q+ S E KE +E+ + EL ++KLE +D + + K A QD++
Sbjct: 697 LQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLE-ADSLEVKASKEQALQDLQQ 755
Query: 585 NDMLDRIKHQHREQGSIKCKLEE--------DLQEATKLLEDKREQLKKSKEHEKLMEGE 636
L+ + S + ++E+ DLQ+ ++ LE +++L K +E +++++ +
Sbjct: 756 QRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQD 815
Query: 637 LEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKE 696
E L QE K + + L + E + ++ E + T+L + +K + +++ E
Sbjct: 816 FETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSE 875
Query: 697 IALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALS-RKSAACQDDLTQALE-KLNH 754
+ + + L+K ++ KH LQ + + +KS + + + L+ +LN
Sbjct: 876 FEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNS 935
Query: 755 VTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKK 814
+ + Q +L Q ++++ QL+ I ++ ++ ++ L+G + + L+ + K
Sbjct: 936 MQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENK 995
Query: 815 LEEMSCQVLQWQKQHQNDLKML----AAKEEQLREFQEEMAALKENLLEDDKEPCCLPQW 870
L++ Q Q + + +L +E ++ Q + + LL ++ + +
Sbjct: 996 LQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEE- 1054
Query: 871 SVPKDTCRLYRGNDQIMTNLEQWAKQQKVANE-------------KLGNQLREQVKYIAK 917
+L + +++N Q Q K+ E K QL+E+ K +
Sbjct: 1055 -------KLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQD 1107
Query: 918 LSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAE 951
+ EK +V+ E KL EIEE K + E
Sbjct: 1108 IQKEKSLKEKELVN---EKSKL-AEIEEIKCRQE 1137
Score = 111 bits (278), Expect = 3e-24
Identities = 178/829 (21%), Positives = 349/829 (42%), Gaps = 120/829 (14%)
Query: 1 MKDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCME---EAMNSSHDK 57
+ D+ E+ + + ++LSL+ + L+ ++ + + ++ E + S+
Sbjct: 598 LHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAA 657
Query: 58 KQAQALAFE---ESEVEFGSSKQCHLR----QLQQLKKKLLVLQQ---ELEFHTEELQTS 107
K AQ + ++ KQ L QL Q+ KL Q+ +LE H +E +
Sbjct: 658 KTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEK 717
Query: 108 YYSLRQYQSILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALA 167
Y SL Q LE Q L K +++ + ++ N + + +QL +
Sbjct: 718 YLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEME 777
Query: 168 GDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYT 227
+ ++S L + +S + E + ++L+ + + QE + + + RI T
Sbjct: 778 KEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFE-TLSQETKIQHEELNNRIQT 836
Query: 228 SPCMIQ----EHQETQKRLSEVWQKVSQQDDLIQELRNKLACSN----ALVLEREKALIK 279
+ +Q E + LS V K+S+ D ++ +++ N A +L+ EK +
Sbjct: 837 TVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKE 896
Query: 280 LQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAV 339
L+ H+ ++ K++ K L+++K++ L++EL ++
Sbjct: 897 LK---------HQLQVQMENTLKEQKELKKSLEKEKEAS-----------HQLKLELNSM 936
Query: 340 SEQ---KRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLT 396
EQ +N +K K E L G E E+K K I LQ L+ L+ TE +
Sbjct: 937 QEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELE--- 993
Query: 397 LKKDKFLQEKDEMLQEL---EKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKS 453
+K Q+ + QEL ++K++ +QN+ K ++ ++ Q E + +QD
Sbjct: 994 ---NKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDL- 1049
Query: 454 KEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLL 513
K E K A+ + N + Q + + +E A LE K ++ L
Sbjct: 1050 KSVEEKLSLAQEDLISNRNQIGNQNKLI---------QELKTAKATLEQDSAKKEQQL-- 1098
Query: 514 DKQKADTIQELQRELQMLQKE-----SSMAEKEQTSNR------KRVEELSLELSEALRK 562
+++ +Q++Q+E + +KE S +AE E+ R K EEL E++++
Sbjct: 1099 -QERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKE 1157
Query: 563 LENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQ 622
+ N K+ L + E K + + ++ + R Q +K +++++ +E K +K +
Sbjct: 1158 ITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAK 1217
Query: 623 LKKSKEHEKLMEGELEALRQEFKKKDKT-----LKENSRKLEEENENLRAELQCCSTQLE 677
L H ++ E E+ + E + T L EN +++E +
Sbjct: 1218 L-----HSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKE--------------WQ 1258
Query: 678 SSLNKYNTSQQVIQDLNKEIALQKESLMSLQ----AQLDKALQKEKHY--LQTTITKEAY 731
SS + + ++ DL EIA+ + ++ + Q A L++ L+ E LQT + +
Sbjct: 1259 SSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLE--- 1315
Query: 732 DALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEI 780
L RK D+ T A+++L E +SLQ TQ +K + E+
Sbjct: 1316 --LQRK----LDNTTAAVQELGR---ENQSLQIKHTQALNRKWAEDNEV 1355
Score = 97.8 bits (242), Expect = 4e-20
Identities = 162/728 (22%), Positives = 310/728 (42%), Gaps = 155/728 (21%)
Query: 366 AHIERKDKDITILQCRLQELQLE------FTETQKLTLKKDKFLQEKDEM---------- 409
+++ K D+T+L+ +Q+LQ ++E K L+K + LQ+++
Sbjct: 76 SNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSA 135
Query: 410 -LQELEKKL--TQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSK------EAECKA 460
LQ LE++L Q +N +K+ K+L +Q+ E+ ++K D+ + E +
Sbjct: 136 ELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTR 195
Query: 461 LQAEVQKLKNSLEEAKQQ--ERLAAQQAAQCKEEAALAGCHLED--TQRKLQKGLLLDKQ 516
L E+ K +++ K + +R + A K+E +++ +R+ + L D+
Sbjct: 196 LTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDEC 255
Query: 517 K---------ADTIQELQREL-----------QMLQKESSMAEKEQTSNRKRVEELSLEL 556
K TI +L+ EL Q LQK S + N+ E L L+
Sbjct: 256 KKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENL-LKK 314
Query: 557 SEALRKLENSDKE----KRQLQKTVAEQDMKMNDM----------LDRIKHQHREQGSIK 602
+ KLE E K+ +Q T+ ++D+ + L RI + E+G
Sbjct: 315 EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEAT 374
Query: 603 CKLEEDLQEAT----------KLLEDKREQLKK---------SKEHEKLME--------- 634
KL+E+L E K L+ +RE+ ++ ++ H KL+E
Sbjct: 375 QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAH 434
Query: 635 GELEALRQ------------------EFKKKDKTLKE---NSRKLEEENENLRAELQCCS 673
G L+ RQ + + ++ LKE NS +L+ + + + + Q
Sbjct: 435 GRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQ 494
Query: 674 TQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKA------LQKEKHYLQTTI- 726
+S+ K +Q ++ + ++I + + + +L+A L K+ L+KE+ L I
Sbjct: 495 ALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQ 554
Query: 727 ----TKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSL-TQTQEKKAQLEEEII 781
+ L K+ Q+ +TQ EKL + + K Q++L Q QE+KA L
Sbjct: 555 AGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLR---- 610
Query: 782 AYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEE 841
A ++R+ L T + +L ES+ +V D +Q + + + L AAK
Sbjct: 611 AAQDRVLSLETSVNELNSQLNESKEKVSQLD----------IQIKAKTELLLSAEAAKTA 660
Query: 842 QLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGND---QIMTNLEQWAKQQK 898
Q + Q + +N L+D ++ + + T +L + Q+ ++L+++ K++
Sbjct: 661 QRADLQNHLDT-AQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEY-KEKY 718
Query: 899 VANEKLGNQLREQVKYIAKLSGE-KDHLHSVMVHLQQENK----------KLKKEIEEKK 947
++ E+ +L Q+K + S E K + LQQ+ + +L K++E +K
Sbjct: 719 LSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEK 778
Query: 948 MKAENTRL 955
+TRL
Sbjct: 779 EIVSSTRL 786
Score = 43.1 bits (100), Expect = 0.001
Identities = 62/293 (21%), Positives = 128/293 (43%), Gaps = 38/293 (12%)
Query: 696 EIALQKESLMSLQAQLDKALQKEKHYLQTTITKEA--YDALSRKSAACQDDLTQALEKLN 753
++ L ++ + LQA L KE+ + + KE Y L ++ A +T +
Sbjct: 84 DVTLLRQEVQDLQASL-----KEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDS----- 133
Query: 754 HVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDK 813
++E +SL+Q L + Q + +++ +E++ +L TE+ ++ + E A ++
Sbjct: 134 --SAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQ 191
Query: 814 KLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVP 873
K+ ++ + L + DLK E R E++A LK+ L++ Q +
Sbjct: 192 KVTRLT-EELNKEATVIQDLK----TELLQRPGIEDVAVLKKELVQ--------VQTLMD 238
Query: 874 KDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQV----KYIAKLSGEKDHLHSVM 929
T R ++++ ++ + Q ++E +QLR ++ + +A E L S +
Sbjct: 239 NMTLERERESEKLKDECKK-LQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSV 297
Query: 930 VHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRTESTQREKVCGTLGWKGL 982
L Q+N+ L + + +K+ TK ES ++ + TL K L
Sbjct: 298 NELTQKNQTLTENLLKKEQD------YTKLEEKHNEESVSKKNIQATLHQKDL 344
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 149 bits (376), Expect = 1e-35
Identities = 226/1061 (21%), Positives = 451/1061 (42%), Gaps = 164/1061 (15%)
Query: 1 MKDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQD--------------NQLC 46
+K E++ E+ + L + + K+ +TLQD NQ
Sbjct: 1062 LKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAI 1121
Query: 47 MEEAMNSSHDKKQAQALAFEESEVEF-----GSSKQCHLRQLQQLKKKLLVLQQELEFHT 101
+++ + S+ D ++A + V GSS+ +L++K+L L++E E
Sbjct: 1122 IQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWK----PELEEKILALEKEKEQLQ 1177
Query: 102 EELQTSYYSLRQYQSILEKQTSDLVLLHHHCKLKEDEVILYEE---EMGNHNENTGEKLH 158
++LQ + L ++IL+K L K ++D+ +E E NEN G++L
Sbjct: 1178 KKLQEA---LTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLR 1234
Query: 159 LAQEQLALAGD-KIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENK 217
Q Q+ + D K+ S ++ Q S S+ LE EP K
Sbjct: 1235 QLQIQVRESIDGKLPSTDQ---------QESCSSTPGLE----------------EPLFK 1269
Query: 218 GDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKAL 277
+T P + + L W S+ +Q +A A + E E
Sbjct: 1270 ATEQH---HTQPVL-------ESNLCPDWPSHSEDASALQG-GTSVAQIKAQLKEIEAEK 1318
Query: 278 IKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELE 337
++L+ +S T+ +++ E++ + LQEQ + Q L +E + + + V E
Sbjct: 1319 VELELKVSSTTS------ELTKKSEEVFQ----LQEQINKQGLEIESLKTVSHEAEVHAE 1368
Query: 338 AVSEQKRNIMKDMMKLE--LDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKL 395
++ ++ + + LE +L +E I +K++D++ L +L E + T+ Q
Sbjct: 1369 SLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTE 1428
Query: 396 TLKKDKFLQ-----------EKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMT 444
++++ ++ E DE +++L+ +L +++ + +E +Q + +L+
Sbjct: 1429 IIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAA 1488
Query: 445 V---KEA-KQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAG--C 498
+ KEA K++KS + E + +++L SL + + +Q +AQ KE+ + G
Sbjct: 1489 LISRKEALKENKSLQEELSLARGTIERLTKSLADVE------SQVSAQNKEKDTVLGRLA 1542
Query: 499 HLEDTQRKL----QKGLLLDKQKADTIQELQRELQMLQKESSMAEKE-----------QT 543
L++ + KL + LL ++ + + + L+ L+ L ++ KE T
Sbjct: 1543 LLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAEST 1602
Query: 544 SNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKC 603
+++ +EL E L+ EN E ++Q V + ++ ++ R + K
Sbjct: 1603 EWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKL----RSTEANKK 1658
Query: 604 KLEEDLQEATKLLEDKREQLKK---SKEHEKL-MEGELEALRQEFKKKDKTLKE------ 653
+ E+ LQEA + +E+ +E+++K SK+ + L +E E + LR E T KE
Sbjct: 1659 ETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLL 1718
Query: 654 -NSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLD 712
++ ++EE E ++ E + S + +S +++ ++ + +QDL +I E +S QA L+
Sbjct: 1719 SSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQI----EGNVSKQANLE 1774
Query: 713 KALQKEKHYLQTTITKEA----------YDALSRKSAACQDDLTQALEKLNHVTS----- 757
EKH QT +T+E D+LS + + + + N S
Sbjct: 1775 AT---EKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSS 1831
Query: 758 --ETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKL 815
E + Q + Q +E+ A LEEE +E + L E L + E+ +++
Sbjct: 1832 HDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEV 1891
Query: 816 EEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQE----EMAALKENLLE--DDKEPCCLPQ 869
+M+ Q Q++ K+ EE+ + +E ++A L ++ D +
Sbjct: 1892 TKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKN 1951
Query: 870 WSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDH---LH 926
+ + L + ++ +Q K++ ++ + E+++ K G K H L
Sbjct: 1952 ELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQ 2011
Query: 927 SVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRTES 967
++ QQE K+L+K+ + K KAL +TES
Sbjct: 2012 ELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTES 2052
Score = 129 bits (324), Expect = 1e-29
Identities = 203/988 (20%), Positives = 414/988 (41%), Gaps = 141/988 (14%)
Query: 7 ERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFE 66
++D+EV L L S + L K D ++EA ++K + A+ +
Sbjct: 2168 KKDKEVQQLQENLDST---VTQLAAFTKSMSSLQDDRDRVIDEA--KKWERKFSDAIQSK 2222
Query: 67 ESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILE-KQTSDL 125
E E+ C + LK +L +++ H EEL+ + L + I E K +++
Sbjct: 2223 EEEIRL-KEDNCSV-----LKDQL----RQMSIHMEELKINISRLEHDKQIWESKAQTEV 2272
Query: 126 VLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKY 185
L C + E +E+ + E T H +Q +LA ++ SL+ L
Sbjct: 2273 QLQQKVCDTLQGE----NKELLSQLEETRHLYHSSQNELAKLESELKSLKDQL------- 2321
Query: 186 QSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSE- 244
+ LSN L +C K +G L GI+ Q+ E +SK +Q +E RL E
Sbjct: 2322 -TDLSN-SLEKC--KEQKGNLEGIIRQQ-EADIQNSKFSYEQLETDLQASRELTSRLHEE 2376
Query: 245 -------VWQKVSQQDDLIQ----ELRNK-----LACSNALVLEREKALIKLQADFASCT 288
+ +S +++ IQ ELR + N L E E+ ++ + + +
Sbjct: 2377 INMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVD 2436
Query: 289 ATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMK 348
T++ + + LK ++++ Q ++ + + L+ + + + + + +
Sbjct: 2437 KTNQ-----------LMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEE 2485
Query: 349 DMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDE 408
+ + L+ L +E +A + ++I L+ + +L +E KL + ++ ++ ++
Sbjct: 2486 RHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLN---SENAKLDAELIQYREDLNQ 2542
Query: 409 MLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKL 468
++ + + Q+ L++ KELE + E +EA +D + ALQ E Q L
Sbjct: 2543 VITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFN--ALQEEKQDL 2600
Query: 469 KNSLEEAKQQERLAAQQAAQCKEEAALAGCHLE----------------DTQRKL----Q 508
+E K +Q +EE L H + +Q+++ +
Sbjct: 2601 SKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEE 2660
Query: 509 KGLLLDKQKADTIQE----LQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLE 564
+ + + K+ A + E L++EL+ L ++ + E + +RV EL+ +L E +KL
Sbjct: 2661 ELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLL 2720
Query: 565 NSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLK 624
KE + L + M+ + + H + E +K K + L+E +L E
Sbjct: 2721 MVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKE------- 2773
Query: 625 KSKEHEKLMEGELEALRQEFKKKDKTLKENSRK-LEEENENLRA---ELQCCSTQLESSL 680
+ L+ E +AL E + +ENS LE+ N+ L + +L S+QLE S
Sbjct: 2774 -----QGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSY 2828
Query: 681 NKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQ-KEKHYLQTTITKEAYDALSRKSA 739
N+ + + + L E ++ L + + K+ + K++ Q + + +L + +
Sbjct: 2829 NQVQSFSKAMASLQNE----RDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMS 2884
Query: 740 ACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRG 799
+ Q+D + L++L ++ + + Q +T+ KAQL+E Y+++ K +LR
Sbjct: 2885 SLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQE----YQDKTKAFQIMQEELRQ 2940
Query: 800 FHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLE 859
+ + E+H ++E+ S ++ + ++ + L ++ K++QL Q + L+ +
Sbjct: 2941 ENLSWQHELHQL--RMEKSSWEIHE-RRMKEQYLMAISDKDQQLSHLQNLIRELRSS--S 2995
Query: 860 DDKEPCCLP-QWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKL 918
+P + Q +T G+ ++ E L QL + +K
Sbjct: 2996 SQTQPLKVQYQRQASPETSASPDGSQNLV-----------YETELLRTQLNDSLK----- 3039
Query: 919 SGEKDHLHSVMVHLQQENKKLKKEIEEK 946
+H + +QQ N + +EEK
Sbjct: 3040 -----EIHQKELRIQQLNSNFSQLLEEK 3062
Score = 127 bits (320), Expect = 4e-29
Identities = 239/1155 (20%), Positives = 472/1155 (40%), Gaps = 219/1155 (18%)
Query: 4 EAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQAL 63
E E + +VSS S+L ++ L + +Q ++ + EA H + Q L
Sbjct: 1317 EKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEA--EVHAESLQQKL 1374
Query: 64 AFEESEVEFGSSKQCHLRQLQ----QLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILE 119
E S+++ + HLR+LQ +L+K + ++++ + + +L +L + Q+ +
Sbjct: 1375 --ESSQLQIAGLE--HLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEII 1430
Query: 120 KQTSDLVLLH---------HHCKLKEDEVILYEEEMGNHNENTGEKLHLAQE-----QLA 165
+Q + LH H ++K+ +V L E M E GE+ Q+ Q A
Sbjct: 1431 EQEDLIKALHTQLEMQAKEHDERIKQLQVELCE--MKQKPEEIGEESRAKQQIQRKLQAA 1488
Query: 166 LAGDKIA-----SLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMG-----QEPE 215
L K A SL+ L+L R + ++ +E QV E ++G QE
Sbjct: 1489 LISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEER 1548
Query: 216 NKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREK 275
+K R + E+ K E ++ L++E+ + + A E ++
Sbjct: 1549 DKLITEMDRSLLENQSLSSSCESLKLALE--GLTEDKEKLVKEIESLKSSKIAESTEWQE 1606
Query: 276 ALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKD-------SQCLHVEEYQNL 328
+LQ ++ ++ + S E E I+ +++ ++++K S + +E +
Sbjct: 1607 KHKELQKEYEILLQSYE---NVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQ 1663
Query: 329 VKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIE-----RKDKDITILQCRL- 382
+++ E+E + E+ R K + L+L + A + K+ T+L
Sbjct: 1664 LQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNAS 1723
Query: 383 --QELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEK----------- 429
+EL+ E + L+ K + EKD + +E++ Q++ ++ K+
Sbjct: 1724 MKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQT 1783
Query: 430 ------------ELEKQQCMATELEMTVKEA-----------KQDKSKEAECKALQAEVQ 466
E E+Q ++ T E+ +D S E ++
Sbjct: 1784 NVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQID 1843
Query: 467 KLKN---SLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTI-Q 522
+LK LEE KQ+ + Q + ++ L+ +D + K+ L + K + + Q
Sbjct: 1844 QLKERIAGLEEEKQKNK-EFSQTLENEKNTLLSQISTKDGELKM---LQEEVTKMNLLNQ 1899
Query: 523 ELQRELQMLQKESSMAEKEQTSNRKRV-------------------------EELSLELS 557
++Q EL + K AE+E+ +R+ E L E+
Sbjct: 1900 QIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMK 1959
Query: 558 EALRKLENSDKEKRQL--QKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKL 615
+ + ++EK+QL +KT E +++ + L++I+ +E G+ + +E +L
Sbjct: 1960 NLKKCVSELEEEKQQLVKEKTKVESEIR-KEYLEKIQGAQKEPGN-----KSHAKELQEL 2013
Query: 616 LEDKREQLKKSKE-----HEKLMEGE-----LEALRQEFKKKDKTLKENSRKLEEENENL 665
L++K++++K+ ++ EK+ E LE ++ E +K + KEN + E +
Sbjct: 2014 LKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKA 2073
Query: 666 RAELQCCSTQLESSLNKYNTSQQVIQD---LNKEIALQKESLMSLQAQLDKALQK----- 717
+AEL L+ + ++ + +V+ D L KE+ KES+ S Q D+ L++
Sbjct: 2074 QAELASFKVLLDDTQSE---AARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQA 2130
Query: 718 -EKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQL 776
EKH + +E DAL R+ ++ + + LN E + LQ++L T + A
Sbjct: 2131 EEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAF 2190
Query: 777 --------------------------------EEEIIAYEERMKKLNTELRKLRGFHQES 804
EEEI E+ L +LR++ +E
Sbjct: 2191 TKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEEL 2250
Query: 805 ELEVHAF--DKKLEEMSCQV-LQWQKQH----QNDLKMLAAKEEQLREF----QEEMAAL 853
++ + DK++ E Q +Q Q++ Q + K L ++ E+ R Q E+A L
Sbjct: 2251 KINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKL 2310
Query: 854 KENL--LEDDKEPCCLPQWSVPKDTCRLYRGN-DQIMTNLEQWAKQQKVANEKLGNQLR- 909
+ L L+D L S + C+ +GN + I+ E + K + E+L L+
Sbjct: 2311 ESELKSLKDQ-----LTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQA 2365
Query: 910 --------------EQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAENTRL 955
++ K I+ LSG+++ + + L+Q++ K KE+E + E +
Sbjct: 2366 SRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENI 2425
Query: 956 CTKALGPSRTESTQR 970
+ + T +
Sbjct: 2426 VLEEENKKAVDKTNQ 2440
Score = 122 bits (306), Expect = 2e-27
Identities = 215/1036 (20%), Positives = 445/1036 (42%), Gaps = 150/1036 (14%)
Query: 7 ERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSS-----HDKKQAQ 61
E +++ LN ++ + L + + ++ L++ + +N S D AQ
Sbjct: 1889 EEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQ 1948
Query: 62 ALAFEESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEF-----HTEELQTSYYS------ 110
+ E E E + K+C + +L++ K++L+ + ++E + E++Q +
Sbjct: 1949 -IKNELLESEMKNLKKC-VSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSH 2006
Query: 111 LRQYQSILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHL----AQEQLAL 166
++ Q +L+++ ++ L C I Y+E++ + E T + L +Q+ L +
Sbjct: 2007 AKELQELLKEKQQEVKQLQKDC-------IRYQEKI-SALERTVKALEFVQTESQKDLEI 2058
Query: 167 AGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIY 226
+ +A +R K Q+ L++ ++L + Q E ++ + K + +
Sbjct: 2059 TKENLAQAVE----HRKKAQAELASFKVL---LDDTQSEAARVLADNLKLKKELQSNKES 2111
Query: 227 TSPCMIQEHQETQKRLSEVWQKVSQQDDLIQE-----------LRNKLACSNALVLEREK 275
M Q+ ++ ++RL + +K ++ +QE L + + +++K
Sbjct: 2112 VKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDK 2171
Query: 276 ALIKLQADFASC-TATHRYPPSSSEECEDIKKILKHLQ--EQKDSQCLHVEEYQNLVKDL 332
+ +LQ + S T + S S +D +++ + E+K S + +E + +K
Sbjct: 2172 EVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLK-- 2229
Query: 333 RVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTET 392
E +++KD ++ ++ +H EE +I R + D I + + Q TE
Sbjct: 2230 --------EDNCSVLKDQLR-QMSIH--MEELKINISRLEHDKQIWESKAQ------TEV 2272
Query: 393 QKLTLKKDKFLQEKDEMLQELEKK---LTQVQNSLLKKEKELEKQQCMATELEMTVKEAK 449
Q D E E+L +LE+ QN L K E EL+ + T+L ++++ K
Sbjct: 2273 QLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCK 2332
Query: 450 QDKSK-EAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCH----LEDTQ 504
+ K E + +A++Q K S E+ + + + + ++ EE + L +
Sbjct: 2333 EQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKE 2392
Query: 505 RKLQKGLLLDKQKADT-IQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKL 563
+Q + +Q+ D I+EL+ L ++E+ + E+E N+K V++ + +L E L+ +
Sbjct: 2393 EAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEE---NKKAVDKTN-QLMETLKTI 2448
Query: 564 ENSD-KEKRQLQKTVAEQDMKMNDMLDRI--KHQHREQGSIKCKLEED--LQEATKLLED 618
+ + ++K QL V ND DRI +Q E+ + LE+D +QEA
Sbjct: 2449 KKENIQQKAQLDSFVKSMSSLQNDR-DRIVGDYQQLEERHLSIILEKDQLIQEAAAENNK 2507
Query: 619 KREQLKKSKEH-------EKLMEGEL----EALRQEFKKKDKTLKE-------NSRKLEE 660
+E+++ + H ++ EL E L Q KD K+ +++LE
Sbjct: 2508 LKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELEN 2567
Query: 661 ENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEK- 719
+ L +L+ E +N Q+ QDL+KEI K S+ L Q+ ALQ+E
Sbjct: 2568 KYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVT-ALQEEGT 2626
Query: 720 ---HYLQTTITKEAYDALS-------RKSAACQDDLT----QALEKLNHVTSETKS---- 761
++ Q + +E LS ++ A +++L +A +K+ + + K
Sbjct: 2627 LGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKH 2686
Query: 762 ------LQQSLTQTQEKK-AQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKK 814
+ ++ T+T E++ A+L +++ E+++ + E + L Q + +
Sbjct: 2687 LHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNS 2746
Query: 815 LEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPK 874
+ + ++ + ++++ LK LA +EQ +E A L E + +
Sbjct: 2747 RDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNS--------TEEN 2798
Query: 875 DTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQ 934
L + N Q+++ EQ + NQ++ K +A L E+DHL +
Sbjct: 2799 SLSHLEKLNQQLLSKDEQLLHLSSQLEDSY-NQVQSFSKAMASLQNERDHLWN------- 2850
Query: 935 ENKKLKKEIEEKKMKA 950
E +K +K E K+ A
Sbjct: 2851 ELEKFRKSEEGKQRSA 2866
Score = 110 bits (274), Expect = 9e-24
Identities = 204/1085 (18%), Positives = 435/1085 (40%), Gaps = 165/1085 (15%)
Query: 7 ERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQ----DNQLCMEEAMNSSHDKKQAQA 62
ERD+ ++ ++ LL Q +L C+ + L+ D + ++E + S K A++
Sbjct: 1547 ERDKLITEMDRSLLENQ----SLSSSCESLKLALEGLTEDKEKLVKE-IESLKSSKIAES 1601
Query: 63 LAFEESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLR---------- 112
++E E + L+ + + + +Q +E +E Q Y LR
Sbjct: 1602 TEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETE 1661
Query: 113 -QYQSILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKI 171
Q Q ++ + K K+ +++ EEE A+E +
Sbjct: 1662 KQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSN 1721
Query: 172 ASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCM 231
AS++ L + +Y++ + L + L E+ + Q N + +
Sbjct: 1722 ASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEA------ 1775
Query: 232 IQEHQE----TQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASC 287
++H T++ + + +QD L R CS + V + A + DF+S
Sbjct: 1776 TEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRP--TCSES-VPSAKSANPAVSKDFSSH 1832
Query: 288 TATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIM 347
+ Y ++ + +K+ + L+E+K + +N L ++ + + +
Sbjct: 1833 DEINNY----LQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQ 1888
Query: 348 KDMMKLELDLHGLREETSAHI-------ERKDKDITILQCRLQEL--------------- 385
+++ K+ L ++EE S E KD L +L EL
Sbjct: 1889 EEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQ 1948
Query: 386 -QLEFTETQKLTLKK--DKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQ---QCMAT 439
+ E E++ LKK + +EK ++++E K ++++ L+K + +K+ + A
Sbjct: 1949 IKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAK 2008
Query: 440 ELEMTVKEAKQD-KSKEAECKALQAEVQKLKNSLE-------EAKQQERLAAQQAAQC-- 489
EL+ +KE +Q+ K + +C Q ++ L+ +++ E+++ + + AQ
Sbjct: 2009 ELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVE 2068
Query: 490 ---KEEAALAGCH--LEDTQR----------KLQKGLLLDK--------QKADTIQE--- 523
K +A LA L+DTQ KL+K L +K QK + ++
Sbjct: 2069 HRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLE 2128
Query: 524 ------------LQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKR 571
+Q +L L++E E+ + + + E+ + L+++ +
Sbjct: 2129 QAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLA 2188
Query: 572 QLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDL---QEATKLLEDKREQLKKSKE 628
K+++ + ++D K R+ EE++ ++ +L+D+ Q+ E
Sbjct: 2189 AFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHME 2248
Query: 629 HEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQ 688
K+ LE +Q ++ K +T + +K+ + L+ E + +QLE + + Y++SQ
Sbjct: 2249 ELKINISRLEHDKQIWESKAQTEVQLQQKV---CDTLQGENKELLSQLEETRHLYHSSQN 2305
Query: 689 VIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTI---------TKEAYDALSRKSA 739
+ L E+ K+ L L L+K +++K L+ I +K +Y+ L
Sbjct: 2306 ELAKLESELKSLKDQLTDLSNSLEKC-KEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQ 2364
Query: 740 ACQDDLTQALEKLN--------------------------HVTSETKSLQQSLTQTQEKK 773
A ++ ++ E++N E K L+ L+Q +E+
Sbjct: 2365 ASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEEN 2424
Query: 774 AQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQ----VLQWQKQH 829
LEEE ++ +L L+ ++ + + + ++ +F K + + V +Q+
Sbjct: 2425 IVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLE 2484
Query: 830 QNDLKMLAAKEEQLREFQEEMAALKENL--LEDDKEPCCLPQWSVPKDTCRLYRGNDQIM 887
+ L ++ K++ ++E E LKE + L + + + + +Q++
Sbjct: 2485 ERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVI 2544
Query: 888 TNLEQWAKQ----QKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEI 943
T + KQ Q N++L N+ + + + + + L LQ+E + L KEI
Sbjct: 2545 TIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEI 2604
Query: 944 EEKKM 948
E K+
Sbjct: 2605 ESLKV 2609
Score = 109 bits (272), Expect = 1e-23
Identities = 240/1145 (20%), Positives = 431/1145 (37%), Gaps = 273/1145 (23%)
Query: 2 KDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQ 61
++ GE DREVS ++ +DI N KR + Q +E + H +
Sbjct: 514 QNRTGEADREVSEISI------VDIAN-----KRSSSAEESGQDVLENTFSQKHKELSVL 562
Query: 62 ALAFEESEVEFGSSK-QCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEK 120
L +E++ E K Q ++ ++ ++L ++ + E + + + LE
Sbjct: 563 LLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPI-----KMKVFLED 617
Query: 121 QTSDLVLLHHHCKLKEDEVILYEEEMGN--HNENTGEKLHLAQEQLALAGDKIASLERSL 178
D L+ + +E + E+E + H T E++ L + L K ++SL
Sbjct: 618 TGQDFPLMPN----EESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDG-DKSL 672
Query: 179 NLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQET 238
+ D Q +E L+ Q+ L+ H IY
Sbjct: 673 SAVPDIGQCHQDELERLKSQILELELNF-------------HKAQEIY------------ 707
Query: 239 QKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSS 298
+K L E +++S + LI+E K AD S T + S
Sbjct: 708 EKNLDEKAKEISNLNQLIEEF-------------------KKNADNNSSAFT-----ALS 743
Query: 299 EECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLH 358
EE + + +K L V E + VK L + L Q+R + + L
Sbjct: 744 EERDQLLSQVKELSM--------VTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLT 795
Query: 359 GLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKD-------EMLQ 411
S + KD I +LQ L ++QL+F+E L LQ K+ E ++
Sbjct: 796 EQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVR 855
Query: 412 ELEKKLTQVQNSLLKKEKELEKQQCMATE-------LEMTVKEAKQDKSK---------- 454
+ K+ ++ +L +KE E+ K + E L+ T++E Q ++
Sbjct: 856 HISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMV 915
Query: 455 --EAECKALQAEVQKLKNSL------EEAKQQ-----------------ERLAAQQAA-- 487
E +L E++ LK L EEAK++ E A Q +
Sbjct: 916 QLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKE 975
Query: 488 QCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKES------------ 535
+ + E L E +RKLQ L+ K+ + L+ EL L+ ES
Sbjct: 976 ELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERG 1035
Query: 536 ---------SMAEKEQTSNRKRVE--------ELSLELSEALRKLENSDKEKRQLQKTVA 578
+EK TS + +E E +EL + LE + Q Q V
Sbjct: 1036 EVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVK 1095
Query: 579 EQDMKMND---MLDRIKHQHREQGSIKCKL------------------------------ 605
+ + + D +D ++ + E +I KL
Sbjct: 1096 QMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSS 1155
Query: 606 ---EEDLQEATKLLEDKREQ---------------LKKSKEHEKLMEGELEALRQEFKKK 647
+ +L+E LE ++EQ LKK++E E+ + EL+ + ++ +
Sbjct: 1156 EHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRL 1215
Query: 648 DKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMS- 706
+ E S+ ENEN+ +L+ Q+ S++ S Q+ES S
Sbjct: 1216 QEQFDEQSK----ENENIGDQLRQLQIQVRESIDGKLPSTD-----------QQESCSST 1260
Query: 707 --LQAQLDKALQKEKHYLQTTITKEA---YDALSRKSAACQ--DDLTQALEKLNHVTSET 759
L+ L KA E+H+ Q + + + S ++A Q + Q +L + +E
Sbjct: 1261 PGLEEPLFKA--TEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEK 1318
Query: 760 KSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMS 819
L+ ++ T + + EE+ +E++ K E+ L+ E+E+ + +KLE
Sbjct: 1319 VELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQ 1378
Query: 820 CQV--LQWQKQHQNDL----KMLAAKEE-------QLREFQEEMAALKENLLE-DDKEPC 865
Q+ L+ ++ Q L K+++ KEE QL E + + ++ ++E +D
Sbjct: 1379 LQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKA 1438
Query: 866 CLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLRE----QVKYIAKLSGE 921
Q + + +D+ + L+ + K E++G + R Q K A L
Sbjct: 1439 LHTQLEMQA------KEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISR 1492
Query: 922 KDHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRTE-STQREKVCGTLGWK 980
K+ L +ENK L++E+ + E TK+L ++ S Q ++ LG
Sbjct: 1493 KEAL--------KENKSLQEELSLARGTIER---LTKSLADVESQVSAQNKEKDTVLGRL 1541
Query: 981 GLPQD 985
L Q+
Sbjct: 1542 ALLQE 1546
Score = 101 bits (252), Expect = 3e-21
Identities = 216/1078 (20%), Positives = 419/1078 (38%), Gaps = 177/1078 (16%)
Query: 1 MKDEAGERDREVSSLNSKLLSLQLD------IKNLHDVCKRQRKTLQDNQLCMEEAMNSS 54
+K + E++ +S+L ++L Q + + V +Q+ ++ + +A S
Sbjct: 149 IKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQ 208
Query: 55 HDKKQAQALAFEESEVEFGSSKQCHLRQLQQL----------KKKLLVLQQELEFHTEE- 103
+QA E + F + + H +L QL ++KL VLQ++LE H E
Sbjct: 209 TQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESL 268
Query: 104 ---------LQTSYYSLRQYQSILEKQTSDLVLLHHHCK-------------LKEDEVIL 141
LQ + Q IL +Q + H+ + L++ E+ +
Sbjct: 269 VGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEV 328
Query: 142 YEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKM 201
E ++ H N E++H EQ AG A LE + K+++ + E +
Sbjct: 329 AERKLSFH--NLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEM---EEKTSHILS 383
Query: 202 LQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRN 261
LQ GQE ++ D K + K L + ++ Q IQ+L +
Sbjct: 384 LQK-----TGQELQSACDALK-------------DQNSKLLQDKNEQAVQSAQTIQQLED 425
Query: 262 KLACSNALVLEREKALIKLQADFASCTA-----THRYPPSSSEECEDIKKILKHLQEQKD 316
+L + + + L Q + AS T+ + E ++K + L+ +K
Sbjct: 426 QLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKG 485
Query: 317 S---QCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIE---- 369
+ + +EE + + L ++ + Q R D E+ + + + S+ E
Sbjct: 486 ALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQ 545
Query: 370 --------RKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKK----- 416
+K K++++L ++E Q E KL L+ + + E+L + E K
Sbjct: 546 DVLENTFSQKHKELSVLLLEMKEAQEEIA-FLKLQLQGKRAEEADHEVLDQKEMKQMEGE 604
Query: 417 --------------------LTQVQNSLLKKEKE---LEKQQCMATELEMT-----VKEA 448
+ ++SL EKE E Q + E+ + +K
Sbjct: 605 GIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKST 664
Query: 449 KQDKSKEAEC-----KALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDT 503
KQD K + Q E+++LK+ + E + A + + +E A +L
Sbjct: 665 KQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQL 724
Query: 504 QRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKL 563
+ +K + + E + +L KE SM T R +V++L + L+EA R+
Sbjct: 725 IEEFKKNADNNSSAFTALSEERDQLLSQVKELSMV----TELRAQVKQLEMNLAEAERQR 780
Query: 564 ENSDKEKRQLQKTVAEQ-----------DMK---MNDMLDRIKHQHREQGSIKCKLEEDL 609
+ + + EQ D+K + + LD ++ Q EQ ++ L+ L
Sbjct: 781 RLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQL 840
Query: 610 QEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLE------EENE 663
Q + + E+++ + + L E K D+ L E R +E EE +
Sbjct: 841 QNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKD 900
Query: 664 NLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSL-QAQLDKALQKEKHYL 722
E+ T+ LN+ S L EI KE L L +A+ K Q E+
Sbjct: 901 QQVTEISFSMTEKMVQLNEEKFS------LGVEIKTLKEQLNLLSRAEEAKKEQVEEDNE 954
Query: 723 QTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETK-SLQQSLTQTQE---KKAQLEE 778
++ K+ YD +S +++L + L + K LQ +L +E + ++LEE
Sbjct: 955 VSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEE 1014
Query: 779 EIIAYEERMKK----LNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLK 834
E+ ++ KK TE ++ + E K +E+ + Q + + +L+
Sbjct: 1015 ELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQ 1074
Query: 835 MLAAKEEQLREFQEEMAALKENL---LEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLE 891
+ E+ +E+ AL + + L+D L Q + ++ + +++T+
Sbjct: 1075 HIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAII----QKLITSNT 1130
Query: 892 QWAKQQKVANEKLGNQLREQVKYIAKLSGEKDH----LHSVMVHLQQENKKLKKEIEE 945
+ VA ++E V +G +H L ++ L++E ++L+K+++E
Sbjct: 1131 DASDGDSVA------LVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQE 1182
Score = 87.0 bits (214), Expect = 8e-17
Identities = 164/807 (20%), Positives = 338/807 (41%), Gaps = 87/807 (10%)
Query: 215 ENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLERE 274
E GD + +P + HQE+ + Q ++++ +LA + LV+E
Sbjct: 15 ELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQ---------EDVQERLAYAEQLVVEL- 64
Query: 275 KALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQ----NLVK 330
K +I+ Q D IKK+ H + + S ++EE + ++
Sbjct: 65 KDIIR-QKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLP 123
Query: 331 DLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLE-- 388
E +S+ ++ ++ M++E H L+E K++ I+ LQ +L + Q E
Sbjct: 124 TEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQE--------KEELISTLQAQLTQAQAEQP 175
Query: 389 ---FTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTV 445
TE ++ + K + LQEK+E + L+ +L+Q Q ++ EK T++ +
Sbjct: 176 AQSSTEMEEFVMMKQQ-LQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHE 234
Query: 446 KEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQR 505
E Q ++ +Q +++ L+ LEE ++ AQ ++E A + +
Sbjct: 235 DELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQ 294
Query: 506 KLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLEN 565
+LQ+ +T++ + E ++L ++ + E+ + ++E E+ L + E
Sbjct: 295 QLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQE---EMHHLLEQFEQ 351
Query: 566 SDKEKRQL--------QKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLE 617
+ + + +L QK AE + K + +L K Q + C +D + +KLL+
Sbjct: 352 AGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSA--CDALKD--QNSKLLQ 407
Query: 618 DKREQLKKSKEHEKLMEGELEALRQEFKKKDKTL-----------------KENSRKLEE 660
DK EQ +S + + +E +L+ +E + L E ++ + E
Sbjct: 408 DKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTE 467
Query: 661 ENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKH 720
EN A LQ +LE+ S +++L E + L+AQ ++ + ++
Sbjct: 468 EN---IASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQ-NRTGEADRE 523
Query: 721 YLQTTITKEAYDALSRKSAACQDDL----TQALEKLNHVTSETKSLQQSLT----QTQEK 772
+ +I A S + QD L +Q ++L+ + E K Q+ + Q Q K
Sbjct: 524 VSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGK 583
Query: 773 KAQLEEEIIAYEERMKKLNTE---LRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQH 829
+A+ + + ++ MK++ E K++ F +++ + EE S ++ ++Q
Sbjct: 584 RAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPN--EESSLPAVE-KEQA 640
Query: 830 QNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTN 889
+ + ++E L + E+ + K+ + DK +P L R QI+
Sbjct: 641 STEHQSRTSEEISLNDAGVELKSTKQ---DGDKSLSAVPDIGQCHQD-ELERLKSQILEL 696
Query: 890 LEQWAKQQKVANEKLGNQLRE---QVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEK 946
+ K Q++ + L + +E + I + D+ S L +E +L +++E
Sbjct: 697 ELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKEL 756
Query: 947 KMKAENTRLCTKALGPSRTESTQREKV 973
M E R K L + E+ ++ ++
Sbjct: 757 SMVTE-LRAQVKQLEMNLAEAERQRRL 782
Score = 78.2 bits (191), Expect = 4e-14
Identities = 172/932 (18%), Positives = 350/932 (37%), Gaps = 208/932 (22%)
Query: 11 EVSSLNSKLLSLQ---LDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEE 67
E++ L S+L SL+ D+ N + CK Q+ L E + Q ++E+
Sbjct: 2306 ELAKLESELKSLKDQLTDLSNSLEKCKEQKGNL-------EGIIRQQEADIQNSKFSYEQ 2358
Query: 68 SEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVL 127
E + +S++ R +++ K + L E +Q + LRQ
Sbjct: 2359 LETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQ-------------- 2404
Query: 128 LHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQS 187
H ++KE E +L +EE E+ + +E+ A DK L +L + +
Sbjct: 2405 -QHDKEIKELENLLSQEE---------EENIVLEEENKKAVDKTNQLMETLKTIKKENIQ 2454
Query: 188 SLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQ 247
+ ++ + LQ + I+G + + H + + + + E K E+
Sbjct: 2455 QKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRG 2514
Query: 248 KVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKI 307
S DDL E NA + + LI+ + D ++ + + +
Sbjct: 2515 LRSHMDDLNSE--------NAKL---DAELIQYREDLNQVITI--------KDSQQKQLL 2555
Query: 308 LKHLQEQKDSQCLH------VEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLR 361
LQ+ K+ + + ++E + +DLR A+ E+K+++ K++ L++ + L
Sbjct: 2556 EVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLT 2615
Query: 362 EETSA----------HIERKDKDITI---------LQCRLQELQLEFTETQKLTLKKDKF 402
+ +A H + K K+ + Q R+ EL+ E QK KK
Sbjct: 2616 RQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGE 2675
Query: 403 LQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKE--------AKQDKSK 454
+++K L+K+L + + E E + EL + E K++K
Sbjct: 2676 IEDK------LKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGL 2729
Query: 455 EAECKALQAEVQKLKNS-------LEEAKQQERLAAQQAAQCKEEAAL------------ 495
A+ ++ + L+NS L+E K++ + ++ AQ KE+ L
Sbjct: 2730 TAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETA 2789
Query: 496 ---------AGCHLEDTQRKL----QKGLLLDKQKADTIQE----------LQRELQMLQ 532
+ HLE ++L ++ L L Q D+ + LQ E L
Sbjct: 2790 FSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLW 2849
Query: 533 KESSMAEKEQTSNRKRVEELSLE------LSEALRKLENSDKEKRQLQKTVAEQDMKMND 586
E K + ++ + S L +A+ L+N + K + +Q +++N
Sbjct: 2850 NELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQ 2909
Query: 587 MLDRIK------HQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKE----HEKLMEGE 636
+ + +++++ ++E+L++ + + QL+ K HE+ M+ +
Sbjct: 2910 EITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQ 2969
Query: 637 ------------------LEALRQEFKKKDKTLKENSRKLEEE-------NENLRAELQC 671
+ LR + + R+ E ++NL E +
Sbjct: 2970 YLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETEL 3029
Query: 672 CSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQL----DKALQKEKHY------ 721
TQL SL + + + IQ LN + E +L QL + ++HY
Sbjct: 3030 LRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNH 3089
Query: 722 ---LQTTITK---------------EAYDALSRKS-----AACQDDLTQALEKLNHVTSE 758
L+ + + + + + RKS Q ++A ++L + E
Sbjct: 3090 CAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQE 3149
Query: 759 TKSLQQSLTQTQEKKAQLEEEIIAYEERMKKL 790
L++ L + ++++ E + EE++++L
Sbjct: 3150 VNELRKLLEEERDQRVAAENALSVAEEQIRRL 3181
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 144 bits (362), Expect = 5e-34
Identities = 209/996 (20%), Positives = 403/996 (40%), Gaps = 165/996 (16%)
Query: 56 DKKQAQALAFEESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQ 115
++++AQAL E+ E++ K L++ L +L Q L EE++T +++ +
Sbjct: 1398 ERERAQALQ-EQGELKVAQGKA--------LQENLALLTQTLAEREEEVETLRGQIQELE 1448
Query: 116 SILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLA------QEQLALAGD 169
E Q + L LL K + EV L +E++ + HL +++L + +
Sbjct: 1449 KQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQRE 1508
Query: 170 KIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSP 229
+I LE+ R+ + L +E + ++ +G++ + K ++ T
Sbjct: 1509 QIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDL------------KKQLVTLE 1556
Query: 230 CMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTA 289
C+ E +E K+ Q LI+EL + AL L D +
Sbjct: 1557 CLALELEENH-------HKMECQQKLIKELEGQRETQRV-------ALTHLTLDLEERSQ 1602
Query: 290 THRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKD 349
+ S + E +L +++D + VK R ++E + QK ++ +D
Sbjct: 1603 ELQAQSSQIHDLESHSTVLARELQERDQE----------VKSQREQIEELQRQKEHLTQD 1652
Query: 350 MMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEM 409
+ + + +L +E +++ + IL+ L++++L E + + + +QE+ E
Sbjct: 1653 LERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEE 1712
Query: 410 LQELEK----KLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEV 465
+ K L ++ L KEKE+E QQ EL+ + +Q + + L +V
Sbjct: 1713 GKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQ------QLQGLHRKV 1766
Query: 466 QKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQ 525
+ L + +Q+ + QQ + +E+ L L+ + Q+ L Q+ ++ LQ
Sbjct: 1767 GETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALA---QRDQELEALQ 1823
Query: 526 RELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMK-- 583
+E Q Q + +++ + + +E+ + L E +L++ ++ R+L++ +A + +
Sbjct: 1824 QEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQ 1883
Query: 584 -MNDMLDRIKHQHREQGSIKCKLEED-------------------------LQEATKLLE 617
+ ++L ++ + REQ L++ L+E + LE
Sbjct: 1884 ALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELE 1943
Query: 618 DKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLK----------ENSRKLEEENENLRA 667
R + + S+ E+ EAL++ K L+ E SR LE L+A
Sbjct: 1944 ALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQA 2003
Query: 668 ELQCC---STQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQT 724
L C S QLE +L + IQD + + L AQ D+ L+ ++ Q
Sbjct: 2004 SLDACQAHSRQLEEALR---IQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQ- 2059
Query: 725 TITKEAYDALSRKSAA--CQDDLTQALEKLNHVTSET--KSLQQSLTQTQEKKAQLEEEI 780
L KS A Q+++ Q + L E + L QS+ + Q AQ E+EI
Sbjct: 2060 ---------LLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEI 2110
Query: 781 IAYEERMKKLNTELR--------------KLRGFHQESELEVHAFDKKLEEMSCQVLQWQ 826
+ E ++ N E KL + E+ L + + ++W+
Sbjct: 2111 LELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWR 2170
Query: 827 KQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQI 886
++ Q+ LA + + QE L+ ++LE D E L +D L R
Sbjct: 2171 EKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRL------QDELELTRR---- 2220
Query: 887 MTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSG----------EKDHLHSVMVHLQQEN 936
E+ + +LG++ EQ + ++SG EK + HLQQ
Sbjct: 2221 ALEKERLHSPGATSTAELGSR-GEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAV 2279
Query: 937 KKLKKEIEEKKMKAENTRLCTKALGPSRTESTQREK 972
+L EI+ +++ N +L S E +RE+
Sbjct: 2280 ARL--EIDRSRLQRHNVQL------RSTLEQVERER 2307
Score = 119 bits (297), Expect = 2e-26
Identities = 179/852 (21%), Positives = 346/852 (40%), Gaps = 140/852 (16%)
Query: 4 EAGERDREVSSLNSKLLSLQLD---------------------IKNLHDVCKRQRKTLQD 42
E ERD+EV S ++ LQ I+ L D RQ K L++
Sbjct: 1624 ELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEE 1683
Query: 43 N----QLCMEEAMNSSHDKKQAQALAFEE----SEVEFGSSKQCHLRQLQQLKKKLLVLQ 94
+ +L + E ++Q EE S+ + GS + H++ + + K+K + Q
Sbjct: 1684 DLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLE--HMKLILRDKEKEVECQ 1741
Query: 95 QELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTG 154
QE H ELQ L Q L ++ + LL +E E+++ ++++ E
Sbjct: 1742 QE---HIHELQELKDQLEQQLQGLHRKVGETSLL---LSQREQEIVVLQQQLQEAREQGE 1795
Query: 155 EKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEP 214
K Q QL A +A ++ L + + Q + E ++ + LQG L
Sbjct: 1796 LKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLK 1855
Query: 215 ENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLERE 274
E G+ +Q+H+E +RL E +++ + +Q L L A E+E
Sbjct: 1856 ERHGE------------LQDHKEQARRLEE---ELAVEGRRVQALEEVLGDLRAESREQE 1900
Query: 275 KALIKLQADFASCTATHRYPPSSSEECE-DIKKILKHLQEQKDSQCLHVEEYQNLVKDLR 333
KAL+ LQ A H + ++ + +LK ++ ++ + ++ + R
Sbjct: 1901 KALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAAR 1960
Query: 334 VELEAVSE-----------------QKRNIMKDMMKLELDLHGLREETSAHIERKDKDIT 376
EA+ E ++ + + + L + AH + ++ +
Sbjct: 1961 ARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALR 2020
Query: 377 ILQCRLQELQLEFTET----QKLTLKKDKFLQEKDEMLQELEKKLTQ-VQNSLLKKEKEL 431
I + +Q+ L + E Q+ ++D+ L+ + E Q LEK L Q VQ +++++++ L
Sbjct: 2021 IQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNL 2080
Query: 432 EKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKE 491
+++ +E E + L V++L+ +L + K+QE L ++ Q
Sbjct: 2081 GQER------------------EEEEIRGLHQSVRELQLTLAQ-KEQEILELRETQQRNN 2121
Query: 492 EAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEE 551
AL H T ++ L LD + LQREL+ LQ E + R++ ++
Sbjct: 2122 LEALP--HSHKTSPMEEQSLKLDSLEP----RLQRELERLQAALRQTEAREIEWREKAQD 2175
Query: 552 LSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRI---------KHQHREQGSIK 602
L+L L++ + + + LQ +V E+D + + D + + H +
Sbjct: 2176 LALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATST 2235
Query: 603 CKLEEDLQEATKLLE------------DKREQLKKSKEHEKLMEGELEALRQEFKKKDKT 650
+L ++ +L E +++ ++ EH + LE R ++ +
Sbjct: 2236 AELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQ 2295
Query: 651 LKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLN-------KEIALQKES 703
L+ ++E E L+ E + ++K S QD K +A ++
Sbjct: 2296 LRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKE 2355
Query: 704 LMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQAL------EKLNHVTS 757
++ LQAQL ++++ Y IT+ A SR+ A L+ +L + + +
Sbjct: 2356 VVLLQAQLTLERKQKQDY----ITRSA--QTSRELAGLHHSLSHSLLAVAQAPEATVLEA 2409
Query: 758 ETKSLQQSLTQT 769
ET+ L +SLTQ+
Sbjct: 2410 ETRRLDESLTQS 2421
Score = 115 bits (289), Expect = 2e-25
Identities = 207/1009 (20%), Positives = 425/1009 (42%), Gaps = 171/1009 (16%)
Query: 29 LHDVCKRQRKTLQD--NQLC-MEEAMN---SSHDKKQAQALAFEESEVEFGSSKQCHLRQ 82
+ V R+R+ +QD QL +EA+N HD+ + + A
Sbjct: 391 VRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKA------------------ 432
Query: 83 LQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDL-----VLLHHHCKLK-- 135
L+Q +KL + L T +LQ SL + + +L+K +L VL +L+
Sbjct: 433 LRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRV 492
Query: 136 EDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELL 195
E+ L + E E+LHLA + + + LE K SLS EL+
Sbjct: 493 NVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEA-------KQSESLS--ELI 543
Query: 196 ECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQK-----------RLSE 244
+ + L G + ++ + + + R S + + T K +LS
Sbjct: 544 TLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSA 603
Query: 245 V-----WQKVSQQDDLIQ-ELRNKLACS---------NALVLEREKALIKLQADFASCTA 289
+ KV L+Q E N+ CS NAL ++ +A + +A + T
Sbjct: 604 LNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTH 663
Query: 290 THRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKD 349
+ E +++ L+ +QE+K EE Q + + R + EA + Q + ++
Sbjct: 664 LEAQLQKAEEAGAELQADLRDIQEEK-------EEIQKKLSESRHQQEAATTQLEQLHQE 716
Query: 350 MMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEM 409
+ E L +E A + K L+ RLQ +++D+ Q+ E
Sbjct: 717 AKRQEEVLARAVQEKEALVREK----AALEVRLQ------------AVERDR--QDLAEQ 758
Query: 410 LQELEKKLTQVQNSLLKKEKELEKQQCMATELEM---TVKEAKQDKSKEAECKALQAEVQ 466
LQ L +++SL + +++ + +LE+ TV +AK+ E C L+ + +
Sbjct: 759 LQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTE 818
Query: 467 KLKNSLEEAKQQERLAAQQAAQCKEEAALA-----GCHLEDTQRKLQKGLLLDKQKADTI 521
+ +A+Q+ AA+Q AQ ++E A H ++ + +K +K+++
Sbjct: 819 R-----SQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREK---WEKERSWHQ 870
Query: 522 QELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQD 581
QEL + L+ L++ EK + R + ++ +E +A R+ E + E Q + E +
Sbjct: 871 QELAKALESLER-----EKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQL-ETE 924
Query: 582 MKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALR 641
+ +L+ + +E L + Q+ +L +D + Q K +E +++ +L+ +
Sbjct: 925 KERVSLLETLLQTQKE-------LADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQ 977
Query: 642 QEFKKKDKTLKENSRKLEEENENL---RAELQCCSTQLESSLNKYNTSQQVIQDLNKEIA 698
+E K+ + +++ L+EE+ +L + +LQ L+S L + SQ++++ +E
Sbjct: 978 RELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKL 1037
Query: 699 LQKESLMSLQAQLDK--------ALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALE 750
+ + +Q +L++ ++KE+ L + +EA ++ +A + D+ +A
Sbjct: 1038 RETQEYNRIQKELEREKASLTLSLMEKEQRLL---VLQEADSIRQQELSALRQDMQEAQG 1094
Query: 751 KLNHVTSETKSLQQSLTQTQ----EKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESEL 806
+ ++++ + L+Q + + + ++AQL EE+ A ++L L + +L
Sbjct: 1095 EQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQL 1154
Query: 807 EVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLE----DDK 862
+ + + +LE ++ ++Q N + A Q+ + ++ E+ E D
Sbjct: 1155 RLRSTESQLEALAA-----EQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDS 1209
Query: 863 EPCCLPQWSVPKDT--CRLYRGNDQIMTNL--------------EQWAKQQKVANEKLGN 906
P W + D R ++T L + W QQ + L +
Sbjct: 1210 APSV---WGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQ--TRDVLRD 1264
Query: 907 QLREQVKYIAKLSGEKDHLHSVMVHLQQ---ENKKLKKEIEEKKMKAEN 952
Q+++ + + EK +H+ + LQ+ +N++ K + E K+ E+
Sbjct: 1265 QVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLES 1313
Score = 112 bits (280), Expect = 2e-24
Identities = 234/1102 (21%), Positives = 440/1102 (39%), Gaps = 198/1102 (17%)
Query: 8 RDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEE 67
++RE+ + L QL++ L R R+ + QL + A ++++ LA E
Sbjct: 463 KERELLQKAREELRQQLEV--LEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRE 520
Query: 68 SEVEFGSSKQCHLRQLQQLKKKLLVLQQELE--------FHTEELQTSYYSLRQYQSILE 119
E +Q + L + L+ L++ LE E+ + + R QSI E
Sbjct: 521 RERLQEMLMGLEAKQSESLSE-LITLREALESSHLEGELLRQEQTEVTAALARAEQSIAE 579
Query: 120 KQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLN 179
+S+ L L+ V KL E LAL DK+ ++ L
Sbjct: 580 LSSSENTLKTEVADLRAAAV----------------KLSALNEALAL--DKVGLNQQLLQ 621
Query: 180 LYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPE--NKGDHSKVRIYTSP-------- 229
L ++ QS S +E E LQ +L + K H + ++ +
Sbjct: 622 L-EEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQA 680
Query: 230 ---CMIQEHQETQKRLSEVWQK----VSQQDDLIQELRNKLACSNALVLEREKALIKLQA 282
+ +E +E QK+LSE + +Q + L QE + + V E+E + + A
Sbjct: 681 DLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAA 740
Query: 283 DFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVK----DLRVELEA 338
A R +E+ + L +E +S ++ ++++ L V+++
Sbjct: 741 LEVRLQAVERDRQDLAEQLQG----LSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQT 796
Query: 339 VSEQKRNIMKDM--MKLELDLHGLREETSAHIERKDKDITILQCRLQEL----QLEFTET 392
V++ K I ++ +KLELD E + A ER + Q + Q +
Sbjct: 797 VTQAKEVIQGEVRCLKLELDT----ERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHE 852
Query: 393 QKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELE--MTVKEAKQ 450
+++ ++K+ +E+ QEL K L ++ ++ E L++QQ TE+E +E ++
Sbjct: 853 KEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQ---TEMEAIQAQREEER 909
Query: 451 DKSKEAECKALQAEVQKLKNSLEEAKQQERL----AAQQAAQCKEEAALAGCHLEDTQRK 506
+++ A C+ +Q E +K + SL E Q + A+QQ + +++ + ++T
Sbjct: 910 TQAESALCQ-MQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGI 968
Query: 507 LQKGLL-LDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLEN 565
LQ L ++ + ++ + +L LQ+ESS +++ +K+VE+L +L
Sbjct: 969 LQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA------- 1021
Query: 566 SDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEED------LQEATKLLEDK 619
D +R +++ V E+ + + K RE+ S+ L E LQEA + + +
Sbjct: 1022 QDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQE 1081
Query: 620 ----REQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENE------------ 663
R+ +++++ +K + ++E LRQE K+K+ +L EE E
Sbjct: 1082 LSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRAS 1141
Query: 664 ---------NLRAELQCCSTQLESSLNK----------------YNTSQQVI-------- 690
L+ L+ +QLE+ + Y+ QQ +
Sbjct: 1142 LWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRP 1201
Query: 691 ----------------QDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTI--TKEAYD 732
D N +L K + L A +A+ H L + T++ D
Sbjct: 1202 ELSGGGDSAPSVWGLEPDQNGARSLFKRGPL-LTALSAEAVASALHKLHQDLWKTQQTRD 1260
Query: 733 ALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQ-------LEEEIIAYEE 785
L + ++ LT + + V +E + LQ+ L+Q QE+K++ LE E++ E
Sbjct: 1261 VLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHE 1320
Query: 786 RMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQ-------------HQND 832
M L + LR+ E++ E E ++ QV Q + D
Sbjct: 1321 TMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEED 1380
Query: 833 LK----MLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMT 888
L+ L K E++ +E AL+E + L Q ++ T L +++ T
Sbjct: 1381 LRTARSALKLKNEEVESERERAQALQEQGELKVAQGKAL-QENLALLTQTLAEREEEVET 1439
Query: 889 ------NLEQWAKQQKVANEKLGNQLR----------EQVKYIAKLSGEKDHLHSVMVHL 932
LE+ + QK A E L L+ EQ++ + K +HL +
Sbjct: 1440 LRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQER 1499
Query: 933 QQENKKLKKEIEEKKMKAENTR 954
+Q+ +++I E + E R
Sbjct: 1500 EQKLTVQREQIRELEKDRETQR 1521
Score = 112 bits (279), Expect = 2e-24
Identities = 186/915 (20%), Positives = 385/915 (42%), Gaps = 101/915 (11%)
Query: 7 ERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHD-KKQAQALAF 65
ER+++++ ++ L+ D + +V + Q L+ +E D KKQ L
Sbjct: 1498 EREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLEC 1557
Query: 66 EESEVEFGSSK-QCHLRQLQQLKKK-------LLVLQQELEFHTEELQTSYYSLRQYQSI 117
E+E K +C + +++L+ + L L +LE ++ELQ + +S
Sbjct: 1558 LALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESH 1617
Query: 118 LEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERS 177
+L K + +++ EE+ E+ + L ++L L ++I LE
Sbjct: 1618 STVLARELQERDQEVKSQREQI----EELQRQKEHLTQDLERRDQELMLQKERIQVLEDQ 1673
Query: 178 LNLYRDKYQSSLSNIEL--------LECQVKMLQGELGGIMGQEPENKG--DHSKVRIYT 227
+ L I+L L Q +++Q G +G +H K+ +
Sbjct: 1674 RTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRD 1733
Query: 228 SPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASC 287
++ QE L E+ ++ QQ +Q L K+ ++ L+ +RE+ ++ LQ
Sbjct: 1734 KEKEVECQQEHIHELQELKDQLEQQ---LQGLHRKVGETSLLLSQREQEIVVLQQQLQEA 1790
Query: 288 TATHRYPPSSSE-ECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVE-----LEAVSE 341
S + + ++ ++ L Q ++ + L E+ Q ++ RV+ L+ E
Sbjct: 1791 REQGELKEQSLQSQLDEAQRALA--QRDQELEALQQEQQQAQGQEERVKEKADALQGALE 1848
Query: 342 QKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDK 401
Q +K+ HG ++ R ++++ + R+Q L+ + + + +++K
Sbjct: 1849 QAHMTLKER-------HGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEK 1901
Query: 402 FL----QEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAK----QDKS 453
L Q+ E QE E + +Q+S L+ + L+++ ELE E++ Q+++
Sbjct: 1902 ALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERD---QELEALRAESQSSRHQEEA 1958
Query: 454 KEAECKALQAEVQKLKNSLEEAKQQ-----ERLAAQQAAQCKEEAALAGCHLEDTQRKLQ 508
A +ALQ + K +L+ +Q E + +A+ +A+L C R+L+
Sbjct: 1959 ARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHS--RQLE 2016
Query: 509 KGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDK 568
+ L + + + Q+L+ + + Q + ++A++++ ++ E LE S A R EN +
Sbjct: 2017 EALRIQEGEIQD-QDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQ 2075
Query: 569 EKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKR----EQLK 624
EK+ L + E++ I+ H+ ++ L + QE +L E ++ E L
Sbjct: 2076 EKQNLGQEREEEE---------IRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALP 2126
Query: 625 KSKEHEKLMEG--ELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNK 682
S + + E +L++L +++ + L+ R+ E R + Q + L +
Sbjct: 2127 HSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKAS 2186
Query: 683 YNTSQQVIQDLNKEIALQKESLMSLQAQLD---KALQKEK-HYLQTTITKEAYDA----- 733
++ Q+V L + + LQ +L+ +AL+KE+ H T T E
Sbjct: 2187 VSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGV 2246
Query: 734 -LSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNT 792
L S + +EK + + LQQ++ + + +++L+ + ++++
Sbjct: 2247 QLGEVSGVEAEPSPDGMEKQSW-RQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVER 2305
Query: 793 ELRKLR----GFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQE 848
E RKL+ Q LE+ K S + Q +D K +A E Q+
Sbjct: 2306 ERRKLKREAMRAAQAGSLEI----SKATASSPTQQDGRGQKNSDAKCVA-------ELQK 2354
Query: 849 EMAALKENLLEDDKE 863
E+ L+ L + K+
Sbjct: 2355 EVVLLQAQLTLERKQ 2369
Score = 109 bits (272), Expect = 1e-23
Identities = 234/1163 (20%), Positives = 459/1163 (39%), Gaps = 254/1163 (21%)
Query: 2 KDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQ 61
+D+ E SSL + LQ +++L K Q D+Q +E+ + +K +
Sbjct: 988 RDDLAALQEESSSLLQDKMDLQKQVEDL----KSQLVAQDDSQRLVEQEVQ----EKLRE 1039
Query: 62 ALAFEESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQ 121
+ + E K L + +++LLVLQ+ +EL +++ Q ++
Sbjct: 1040 TQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKEL 1099
Query: 122 TSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQL--ALAGDKIASLERSLN 179
++ + LL K KE + + E ++ E + H+ ++QL +L + + + L
Sbjct: 1100 SAQMELLRQEVKEKEADFLAQEAQLLEELEAS----HITEQQLRASLWAQEAKAAQLQLR 1155
Query: 180 LYRDKYQSSLSNIELLECQVK----------------MLQGELGGIM------------- 210
L +S+ S +E L + + LQ LG +
Sbjct: 1156 L-----RSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSA 1210
Query: 211 ----GQEPENKGDHSKVRI---------------------------YTSPCMIQEHQETQ 239
G EP+ G S + T + + Q+ +
Sbjct: 1211 PSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLE 1270
Query: 240 KRLSEVWQKVSQQDDLIQELRNKLACS-----------NALVLEREKALIKLQADFASCT 288
+RL++ + SQ +Q+L+ +L+ + N+L E L++L AS
Sbjct: 1271 ERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSL----ESELMELHETMASLQ 1326
Query: 289 ATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMK 348
+ R E + +++L+ +E +Q VE Q V + R + A
Sbjct: 1327 SRLRRAELQRMEAQGERELLQAAKENLTAQ---VEHLQAAVVEARAQASAAGI------- 1376
Query: 349 DMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEK-- 406
LE DL R ++ K++++ + R Q LQ E +L + + K LQE
Sbjct: 1377 ----LEEDLRTARSA----LKLKNEEVESERERAQALQ----EQGELKVAQGKALQENLA 1424
Query: 407 --DEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQD----KSKEAECKA 460
+ L E E+++ ++ + + EK+ E Q+ L + +K+ Q+ + + E +
Sbjct: 1425 LLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEK 1484
Query: 461 LQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADT 520
++ ++ L +++E +Q+ + +Q + +++ +TQR + + LL+ +K D
Sbjct: 1485 CRSVLEHLPMAVQEREQKLTVQREQIRELEKD--------RETQRNVLEHQLLELEKKDQ 1536
Query: 521 --------IQELQRELQML-----------------QKESSMAEKEQTSNRKRVEELSLE 555
+Q+L+++L L QK E ++ + R + L+L+
Sbjct: 1537 MIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLD 1596
Query: 556 LSEALRKLENSDKEKRQLQ-------KTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEED 608
L E ++L+ + L+ + + E+D ++ ++I+ R++ + LE
Sbjct: 1597 LEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERR 1656
Query: 609 LQE-----------------ATKLLEDKREQLKKS----------------------KEH 629
QE TK+LE+ EQ+K S K
Sbjct: 1657 DQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGP 1716
Query: 630 EKLMEGELEALRQEFKKKDKTL---KENSRKLEEENENLRAELQCCSTQL-ESSL----- 680
K G LE ++ + K+K + +E+ +L+E + L +LQ ++ E+SL
Sbjct: 1717 SKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQR 1776
Query: 681 -NKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSA 739
+ QQ +Q+ ++ L+++SL S + +AL + L+ + +E A ++
Sbjct: 1777 EQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELE-ALQQEQQQAQGQEER 1835
Query: 740 ACQ--DDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKL 797
+ D L ALE+ H+T K L +E+ +LEEE+ R++ L L L
Sbjct: 1836 VKEKADALQGALEQA-HMT--LKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDL 1892
Query: 798 RGFHQESELEVHAFDKKL------EEMSCQVLQ--W------QKQHQNDLKMLAAKEEQL 843
R +E E + A ++ E+ + LQ W K+ +L+ L A+ +
Sbjct: 1893 RAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSS 1952
Query: 844 REFQEEMAALKENLLE---------DDKEPCCLPQ----WSVPKDTCRLYRGNDQIMTNL 890
R +E A E L E KE L Q S+ T L D +
Sbjct: 1953 RHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHS 2012
Query: 891 EQWAKQQKVANEKLGNQ---LREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKK 947
Q + ++ ++ +Q +E V+ + + ++D + H Q+ + L+K + ++
Sbjct: 2013 RQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRD---EELRHQQEREQLLEKSLAQRV 2069
Query: 948 MKAENTRLCTKALGPSRTESTQR 970
EN + LG R E R
Sbjct: 2070 Q--ENMIQEKQNLGQEREEEEIR 2090
Score = 82.8 bits (203), Expect = 1e-15
Identities = 150/760 (19%), Positives = 306/760 (40%), Gaps = 101/760 (13%)
Query: 233 QEHQETQKRLSEVWQ-KVSQQDDLIQELRNKLACSNALVLER---------EKALIKLQA 282
QE Q+ Q L Q KV Q QEL +L + + +R ++ L++L+
Sbjct: 46 QEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEE 105
Query: 283 DFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQ 342
+ + CE + ++ L+ LH+E+ + K LR ++E ++
Sbjct: 106 E--------------QQRCESLAEVNTQLR-------LHMEKADVVNKALREDVEKLTVD 144
Query: 343 KRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKF 402
++M+ E +E +++ + + L + + F E + T
Sbjct: 145 WSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSAT------ 198
Query: 403 LQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKE----AKQDKSKEAEC 458
D L EL+ + ++ SLL C+ + +E + D + A+
Sbjct: 199 ----DRDLMELKAEHVRLSGSLLTC--------CLRLTVGAQSREPNGSGRMDGREPAQL 246
Query: 459 KALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKA 518
L A+ Q+L+ E +Q+ Q K + L L+D +L LL QK
Sbjct: 247 LLLLAKTQELEKEAHER-------SQELIQLKSQGDLEKAELQDRVTELS-ALLTQSQKQ 298
Query: 519 DTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVA 578
+ ++ ++ ++ L++ + E T + LS N+ +EK LQ+ +
Sbjct: 299 N--EDYEKMIKALRETVEILETNHTELMEHEASLS----------RNAQEEKLSLQQVIK 346
Query: 579 EQDMKMNDMLDRIKHQHREQGSIKCKL----EEDLQEATKLLEDKREQLKKSKEHEKLME 634
+ M + D I + S++ + D Q+A K L R L + ++ + +
Sbjct: 347 DITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLR 406
Query: 635 GELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLN 694
+L ++ L++ + EEE + LR LQ + + ++ + Q + L+
Sbjct: 407 QQLAGCQEAVN----LLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLS 462
Query: 695 KEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNH 754
KE L +++ L+ QL+ L++E L+ + L + + Q + E+L+
Sbjct: 463 KERELLQKAREELRQQLE-VLEQEAWRLRRVNVE-----LQLQGDSAQGQKEEQQEELHL 516
Query: 755 VTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKK 814
E + LQ+ L + K+++ E+I E ++ + E LR E + ++
Sbjct: 517 AVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQS 576
Query: 815 LEEMSCQVLQWQKQHQNDLKMLAAKEEQLRE-FQEEMAALKENLLEDDKEPCCLPQWSVP 873
+ E+S K DL+ A K L E + L + LL+ ++E SV
Sbjct: 577 IAELSSSE-NTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEE-----NQSVC 630
Query: 874 KDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQ 933
+ + + +L + K+++ EK L Q++ + E L + + +Q
Sbjct: 631 SRMEAAEQARNALQVDLAEAEKRREALWEK-NTHLEAQLQKAEEAGAE---LQADLRDIQ 686
Query: 934 QENKKLKKEIEEKKMKAENTRLCTKALGPSRTESTQREKV 973
+E ++++K++ E + + E T L E+ ++E+V
Sbjct: 687 EEKEEIQKKLSESRHQQE---AATTQLEQLHQEAKRQEEV 723
Score = 51.6 bits (122), Expect = 4e-06
Identities = 116/514 (22%), Positives = 209/514 (40%), Gaps = 82/514 (15%)
Query: 471 SLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQM 530
SL+ +++ LA QQ Q E A + L+++Q Q+ L ++ + + + Q
Sbjct: 15 SLQLVLEEQVLALQQ--QMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQE 72
Query: 531 LQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDR 590
L+K + VEE +L+ E L +LE E++Q +++AE + ++
Sbjct: 73 LEKRLEATGGPIPQRWENVEEPNLD--ELLVRLE----EEQQRCESLAEVNTQLR----- 121
Query: 591 IKHQHREQGSIKCK-LEEDLQEATKLLEDKREQLKKSK----------------EHEKLM 633
H E+ + K L ED+++ T R++L + + EH +L+
Sbjct: 122 ---LHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLL 178
Query: 634 E--GELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQ 691
E+ R+ F + + +L+ E+ L L C +L +
Sbjct: 179 SLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRM 238
Query: 692 DLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEK 751
D + L+ L A+ + L+KE H + + + + KS Q DL +A E
Sbjct: 239 D-----GREPAQLLLLLAKTQE-LEKEAH-------ERSQELIQLKS---QGDLEKA-EL 281
Query: 752 LNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAF 811
+ VT L LTQ+Q++ E+ I A E ++ L T +L E+ L +A
Sbjct: 282 QDRVTE----LSALLTQSQKQNEDYEKMIKALRETVEILETNHTEL--MEHEASLSRNAQ 335
Query: 812 DKKL--EEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQ 869
++KL +++ + Q + +++ + E L E +++ D +
Sbjct: 336 EEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSL----ELDSSIFSQFDYQDADKALTLV 391
Query: 870 WSVPKDTCRLYRGNDQIMTNLEQWAKQQKVAN---------EKLGNQLREQVKYIAKLSG 920
SV L R + +Q A Q+ N E+ G LR++++ KL+G
Sbjct: 392 RSV------LTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQ---KLTG 442
Query: 921 EKDHLHSVMVHLQQENKKLKKEIEEKKMKAENTR 954
E+D L V LQ E L KE E + E R
Sbjct: 443 ERDTLAGQTVDLQGEVDSLSKERELLQKAREELR 476
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 141 bits (355), Expect = 4e-33
Identities = 230/1035 (22%), Positives = 450/1035 (43%), Gaps = 150/1035 (14%)
Query: 1 MKDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQA 60
+ D ER +V + S++ S + I++ + + +Q +LC+E+ ++ KQ
Sbjct: 1889 VNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEK----DNENKQK 1944
Query: 61 QALAFEESEVEFGSSKQCHLR-QLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILE 119
+ EE E+ +S++ LR +L + KK L Q E E+ Q LE
Sbjct: 1945 VIVCLEE-ELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQE-----------LE 1992
Query: 120 KQTSDLVLLHHHC-KLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSL 178
S+ + HC ++ E EV E T L+ + L DK E+
Sbjct: 1993 SHQSECL----HCIQVAEAEV----------KEKTELLQTLSSDVSELLKDKTHLQEKLQ 2038
Query: 179 NLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPE-----NKGDHSKVRIYTS-PCMI 232
+L +D SL+ EL E Q+ L E ++ + ++ D+ K+ + + +
Sbjct: 2039 SLEKDSQALSLTKCEL-ENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAAL 2097
Query: 233 QEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHR 292
E E RLS ++V Q I++LR ++ L + L + + R
Sbjct: 2098 VEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERE----------R 2147
Query: 293 YPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMK 352
S ++ E++++ L+ +E ++ L E + V+ L+ ++E ++ + +
Sbjct: 2148 ENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMA-------RSLKV 2200
Query: 353 LELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDE---M 409
ELDL LR E L ++QE Q + +E KL L+EK++
Sbjct: 2201 FELDLVTLRSEKEN-----------LTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQ 2249
Query: 410 LQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLK 469
++E K ++ + LK+ E C E+ M E D E E + L+ ++KL+
Sbjct: 2250 IKEESKTAVEMLQNQLKELNEAVAALCGDQEI-MKATEQSLDPPIEEEHQ-LRNSIEKLR 2307
Query: 470 NSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQ 529
LE ++++ QQ + + A L +E+ +R+L+ + A + + E++
Sbjct: 2308 ARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVE 2367
Query: 530 MLQKE----------------SSMAEKEQTSN-----RKRVEELSLELSEALRKLENSDK 568
L+ + + +EKE +N ++R+ EL + S L+ ++
Sbjct: 2368 TLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQ 2427
Query: 569 EKRQL-QKTVAEQDM---KMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLK 624
EK Q+ +K+ +M ++ ++ +R+ H +Q + K K E++L + LE ++ QL
Sbjct: 2428 EKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAK-EQNLSSQVECLELEKAQLL 2486
Query: 625 KSKEHEK----LMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSL 680
+ + K +++ + L QE + K+ K +EE L+ ++Q QL S L
Sbjct: 2487 QGLDEAKNNYIVLQSSVNGLIQEVEDG----KQKLEKKDEEISRLKNQIQD-QEQLVSKL 2541
Query: 681 NKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTT--ITKEAYDALSRKS 738
++ Q+ ++ N E+ + + L+ ++ + LQ + LQ T + + +Y L +
Sbjct: 2542 SQVEGEHQLWKEQNLEL---RNLTVELEQKI-QVLQSKNASLQDTLEVLQSSYKNLENEL 2597
Query: 739 AACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLR 798
+ D +EK+N +T++ LQ+ + + +K A+L+EE L+ E +L
Sbjct: 2598 ELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEE----------LSGEKNRLA 2647
Query: 799 GFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLL 858
G Q E+ + +L+E++ + + +K K KE ++R EE+A + L
Sbjct: 2648 GELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVR---EEIAEYQLRLH 2704
Query: 859 EDDKEPCCL-----PQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKV-------ANEKLGN 906
E +K+ L Q+ V T R + +T+ E+ QK+ + E+L N
Sbjct: 2705 EAEKKHQALLLDTNKQYEVEIQTYR------EKLTSKEECLSSQKLEIDLLKSSKEELNN 2758
Query: 907 QLREQVKYIAKLSGEKDHLHSVMVHLQQENK----KLKKEIEEKKMKAENTRLCTKALGP 962
L+ + + +L K + L++EN+ K+K I+ K E + K L
Sbjct: 2759 SLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKEL-- 2816
Query: 963 SRTESTQREKVCGTL 977
S+ ++ Q ++ GT+
Sbjct: 2817 SQLQAAQEKQKTGTV 2831
Score = 119 bits (299), Expect = 1e-26
Identities = 211/1054 (20%), Positives = 427/1054 (40%), Gaps = 172/1054 (16%)
Query: 72 FGSSKQCHL-----RQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLV 126
F +S HL Q Q+L+ K+ L+ L+ H +E++ ++ Q LEK +L+
Sbjct: 271 FDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELI 330
Query: 127 LLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQ 186
DE++ T + A + K+ L L+ R +
Sbjct: 331 EKEKVLNKCRDELV-----------RTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAE 379
Query: 187 SSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVW 246
S+ + LE ++K + E + ++ + + I + QE Q+ + + +
Sbjct: 380 SARCS---LEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQ 436
Query: 247 QKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKK 306
++ + + Q+L N L E ++ L + + F + S EE +
Sbjct: 437 AELDKLTSVKQQLENNLE-------EFKQKLCRAEQAFQASQIKENELRRSMEEMKKENN 489
Query: 307 ILKHLQEQKDSQCLHVE-----------EYQNLVKDLRVE-----------LEAVSEQKR 344
+LK EQK + H+E + QN ++++ + E +++Q+
Sbjct: 490 LLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQEN 549
Query: 345 NIMKDMMKLEL-DLHGLREETSAHIERKDKDITILQCRLQELQ---------LEFTETQK 394
++ + +KL + DL R+ + +++++ I L +L + + LE + +
Sbjct: 550 SLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEY 609
Query: 395 LTLKKDKFL-----QEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAK 449
LK++K L E +++L ++E + +Q+ + E L+ QQ + E V+ +
Sbjct: 610 EELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLE 669
Query: 450 QDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQK 509
D+ L E++ L N L+ + + +++A + + Q++++
Sbjct: 670 MDREN------LSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSD---QKHQKEIEN 720
Query: 510 GLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKE 569
L Q +++L+ +LQ+L E ++ E L L L ++
Sbjct: 721 MCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDH 780
Query: 570 KRQLQKTVAEQDMKMNDMLDRIKHQHREQGSI-----KCKLEEDLQ-EATKLLEDKREQL 623
+R L +Q M+ I EQGS+ +C+LE D + + +L+++ + L
Sbjct: 781 QRSL--LAFDQQPAMHHSFANI---IGEQGSMPSERSECRLEADQSPKNSAILQNRVDSL 835
Query: 624 KKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAE--------------- 668
+ S E +K M +L+ +E + ++EN K E+ +++ AE
Sbjct: 836 EFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAH 895
Query: 669 ----------LQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKE 718
L+ +L+ +K T Q IQ+L K L ++SL LQ L + L E
Sbjct: 896 QNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQL-LSETLSLE 954
Query: 719 KHYLQTTIT--KEAYDALSRKSAACQD----------DLTQALEKL-NHVTSETKSLQQS 765
K + + I+ K + L++++ ++ +L Q E N++ KS+ +
Sbjct: 955 KKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISEL 1014
Query: 766 LTQTQEKKAQL----EEEIIAYE----------ERMKKLNTELRKLRGF--HQESELE-- 807
Q +++K L EE AYE E+ KL L + ++++ELE
Sbjct: 1015 SDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQL 1074
Query: 808 VHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLR--------EFQEEMAALKENLLE 859
AF K+ +E ++ ++++QN + L ++ LR + E LK+ ++
Sbjct: 1075 KEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMT 1134
Query: 860 DDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVK------ 913
+E Q + K+ L + N+Q+M ++ + Q + +E + N ++E+
Sbjct: 1135 LKEE-----QNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCN 1189
Query: 914 -------YIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRTE 966
+ ++S + + V + NK+LK + EK+ + L T G T
Sbjct: 1190 FKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQT-IRGDLETS 1248
Query: 967 STQREKVCGTLGWKGLPQDMGQRMDLTKYIGMPH 1000
+ Q + G K D + KYI PH
Sbjct: 1249 NLQDMQSQEISGLKDCEIDAEE-----KYISGPH 1277
Score = 114 bits (284), Expect = 6e-25
Identities = 209/1002 (20%), Positives = 404/1002 (40%), Gaps = 131/1002 (13%)
Query: 9 DREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEES 68
D+E + ++L KN+H+V + + L + +E + K AF+ S
Sbjct: 411 DQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQAS 470
Query: 69 EVEFGSSKQCHLRQLQQLKKKLLVLQQELE------FHTE-ELQTSYYSLRQYQSILEKQ 121
+++ + R ++++KK+ +L+ E H E EL+ L Q Q+ E+
Sbjct: 471 QIKENELR----RSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEM 526
Query: 122 TSDLVLLHHHCKLKEDEVILYE-EEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNL 180
+ K E +L + +E N EN+ L E+L LA +A LE+ +
Sbjct: 527 KA---------KNTSQETMLRDLQEKINQQENS-----LTLEKLKLA---VADLEKQRDC 569
Query: 181 YRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQK 240
+D + +IE L ++ + E ++ K ++ +++ + + E +K
Sbjct: 570 SQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWK-SENEK 628
Query: 241 RLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTA----THRYPPS 296
L+++ + I L L E + + L+ D + + H S
Sbjct: 629 LLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDS 688
Query: 297 SSEECEDIKKILKHLQEQK-----------DSQCLHVEEYQNLVKDLRVELEAVSEQKRN 345
S E E K LQ++ ++ CL + V+DL +L+ +S N
Sbjct: 689 KSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLS----N 744
Query: 346 IMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQE 405
+ D + DLH E ++ KD + + + L L F + + + E
Sbjct: 745 EIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSL-LAFDQQPAMHHSFANIIGE 803
Query: 406 KDEMLQELE----------KKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKE 455
+ M E K +QN + E LE Q+ M ++L+ +E Q K E
Sbjct: 804 QGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKG-E 862
Query: 456 AECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDK 515
E ++AE Q ++ + E Q+ + + + A LE+ +++LQ LL DK
Sbjct: 863 IEENLMKAE-QMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQ--LLNDK 919
Query: 516 QKAD--TIQELQ----------RELQMLQKESSMAEKEQTS----NRKRVEELSLELSEA 559
+ + IQEL+ +ELQ+L + S+ +KE +S N++ +EEL+ E +
Sbjct: 920 VETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQE-NGT 978
Query: 560 LRKLENS-DKEKRQL-QKT------VAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQE 611
L+++ S ++EK L QK+ + E++ ++++ D+ K + K L + +E
Sbjct: 979 LKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQE-------KLILLQRCEE 1031
Query: 612 ATKLLEDKREQLKKSKEHEKLME--------------GELEALRQEFKKKDKTLKENSRK 657
ED ++ K ++E +E ELE L++ F K+ +
Sbjct: 1032 TGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAF 1091
Query: 658 LEEENENLRAELQCCSTQLESSL-NKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQ 716
EE N+NL EL+ L S + + N S+ L +EI KE +Q +++ LQ
Sbjct: 1092 AEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQ 1151
Query: 717 KEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQL 776
+ + ++ TK CQ+ ++ + N V Q + Q
Sbjct: 1152 ENEQLMKVMKTKH----------ECQNLESEPIR--NSVKERESERNQCNFKPQMDLEVK 1199
Query: 777 EEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEM-----SCQVLQWQKQHQN 831
E + +Y ++ +L LR QESE E +L+ + + + Q Q +
Sbjct: 1200 EISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEIS 1259
Query: 832 DLK--MLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGND-QIMT 888
LK + A+E+ + E + +N + + + + C + + +++T
Sbjct: 1260 GLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVT 1319
Query: 889 NLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMV 930
L + A K+ ++ + + + L+ + LH +V
Sbjct: 1320 ELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELV 1361
Score = 112 bits (279), Expect = 2e-24
Identities = 186/928 (20%), Positives = 394/928 (42%), Gaps = 136/928 (14%)
Query: 144 EEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQ 203
E + N + KLHL + QL + LE+ + + + +E C + L
Sbjct: 1798 ESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQEL- 1856
Query: 204 GELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVW-QKVSQQDDLIQELRNK 262
+ + ++G +S + ++ ++ + ++++ W ++ ++ + +R++
Sbjct: 1857 ------LQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSE 1910
Query: 263 LAC--SNALVLE-------------------REKALIKLQADFASCTA----------TH 291
A AL LE ++K ++ L+ + + T+ T
Sbjct: 1911 KASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTM 1970
Query: 292 RYPPSSSEECEDIKKILKHLQEQKDSQCLH--------VEEYQNLVKDLRVELEAVSEQK 343
++ ++ + K E S+CLH V+E L++ L ++ + + K
Sbjct: 1971 SKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDK 2030
Query: 344 RNIMKDMMKLELDLHGL---REETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKD 400
++ + + LE D L + E I + +K+ +L + LQ +E+ L
Sbjct: 2031 THLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVS 2090
Query: 401 KFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQC-MATELEMTVKEAKQDKSKEAECK 459
K L+ E +L+ Q + + + +EK + + + + + A++ K +E E
Sbjct: 2091 KALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKEREREND 2150
Query: 460 ALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLL----LDK 515
+L+ +V+ L+ L+ +++ + L A K E +E+ R L+ L L
Sbjct: 2151 SLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRS 2210
Query: 516 QKAD---TIQELQRELQMLQK-----ESSMAEKEQTSNRKRVEELSLELSEALRKLENSD 567
+K + IQE Q +L L K +S + EKEQ ++ E A+ L+N
Sbjct: 2211 EKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAE-----IQIKEESKTAVEMLQNQL 2265
Query: 568 KEKRQLQKTVA--EQDMKMNDM-LD-RIKHQHREQGSIKCKLEEDLQEATKLLEDKREQL 623
KE + + ++ MK + LD I+ +H+ + SI+ KL L+ K +QL
Sbjct: 2266 KELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIE-KLRARLEADEKKQLCVLQQL 2324
Query: 624 KKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEEN-----ENLRAELQCCSTQLES 678
K+S+ H L++G +E L +E + +T +E++ LE EN E L+A+++ + L
Sbjct: 2325 KESEHHADLLKGRVENLERELEIA-RTNQEHA-ALEAENSKGEVETLKAKIEGMTQSLRG 2382
Query: 679 SLNKYNTSQQVIQDLNKEIALQKESLMSL------------QAQLDKALQKEKHYLQTTI 726
T + ++L E+ ++E + L + + +K KEK +
Sbjct: 2383 LELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEM 2442
Query: 727 TKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQ-------QSLTQTQEKKAQLE-- 777
+ L+ + AA +D K +++S+ + L+ Q L + + L+
Sbjct: 2443 LQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSS 2502
Query: 778 -----EEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQND 832
+E+ +++++K + E+ +L+ Q+ E V KL ++ + W++Q+
Sbjct: 2503 VNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLV----SKLSQVEGEHQLWKEQNLEL 2558
Query: 833 LKMLAAKEEQLREFQEEMAALKENL---------LEDDKEPCCLPQWSVPKDTCRLYRGN 883
+ E++++ Q + A+L++ L LE++ E + + S + ++
Sbjct: 2559 RNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKE 2618
Query: 884 DQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEI 943
++ + + A QK A +L+E+ LSGEK+ L + L +E K K ++
Sbjct: 2619 TELQREMHEMA--QKTA------ELQEE------LSGEKNRLAGELQLLLEEIKSSKDQL 2664
Query: 944 EEKKMKAENTRLCTKALGPSRTESTQRE 971
K++ EN+ L K+L + ++E
Sbjct: 2665 --KELTLENSEL-KKSLDCMHKDQVEKE 2689
Score = 103 bits (258), Expect = 6e-22
Identities = 185/885 (20%), Positives = 355/885 (40%), Gaps = 118/885 (13%)
Query: 1 MKDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHD---K 57
+K+ R E + LL + K +VC + + L++ + C+ ++ N + + K
Sbjct: 472 IKENELRRSMEEMKKENNLLKSHSEQK-AREVCHLEAE-LKNIKQCLNQSQNFAEEMKAK 529
Query: 58 KQAQALAFEESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSI 117
+Q + + + ++Q + L++LK + L+++ + + L+ + + Q
Sbjct: 530 NTSQETMLRDLQEKI--NQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDK 587
Query: 118 LEKQTSDLVLLHHHCKLKEDEVILYEEEMG------NHNENTGEKLHLAQEQLALAGDKI 171
L K + L +LK+ E +EE + NE ++ +E L KI
Sbjct: 588 LSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQ---SKI 644
Query: 172 ASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCM 231
LE L + K + LE + L E+ + N D V + T
Sbjct: 645 NHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNL-----HNVLDSKSVEVETQKLA 699
Query: 232 IQEHQET--------QKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQAD 283
E Q+ QK + + K SQ +++L +KL + ++++++ L A+
Sbjct: 700 YMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAE 759
Query: 284 -------------------------------------FASCTATHRYPPSSSEEC----E 302
FA+ PS EC +
Sbjct: 760 YESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEAD 819
Query: 303 DIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLRE 362
K LQ + DS +E + + DL+ + E + + K I +++MK E
Sbjct: 820 QSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVA 879
Query: 363 ETSAHIERKDKDITILQCRLQELQLEFTETQK-LTLKKDKFLQEKDEMLQELEKKLTQVQ 421
ETS I + +D + Q + E +K L L DK E+ E +QEL+K ++
Sbjct: 880 ETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAE-IQELKKSNHLLE 938
Query: 422 NS-----LLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAE--------VQKL 468
+S LL + LEK++ M++ + + +E ++ + K + A +QK
Sbjct: 939 DSLKELQLLSETLSLEKKE-MSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKS 997
Query: 469 KNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQREL 528
++ ++E+ ++ + Q K+E + E+T + L K KA QE +L
Sbjct: 998 ESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYED--LSQKYKA--AQEKNSKL 1053
Query: 529 QMLQKE-SSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQ-KTVAEQDMKMND 586
+ L E +S+ E + + E + E E L KL +++ + L + Q ++
Sbjct: 1054 ECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSE 1113
Query: 587 MLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKK 646
M D + E G +K ++ +E K+ ++ + L+++++ K+M+ + E E +
Sbjct: 1114 MTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEP 1173
Query: 647 KDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDL--NKEIALQKESL 704
++KE + + N + +L+ E SL+ YN ++ + NKE+ LQ+
Sbjct: 1174 IRNSVKERESERNQCNFKPQMDLEV----KEISLDSYNAQLVQLEAMLRNKELKLQES-- 1227
Query: 705 MSLQAQLDKALQKEKHYLQT----TITKEAYDALSRKSAACQDDLTQALEK-------LN 753
+K + +H LQT T D S++ + +D A EK L+
Sbjct: 1228 -------EKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELS 1280
Query: 754 HVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLR 798
++ LQ SL T K +LE+ + +L TEL R
Sbjct: 1281 TSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSR 1325
Score = 102 bits (255), Expect = 1e-21
Identities = 222/1036 (21%), Positives = 421/1036 (40%), Gaps = 183/1036 (17%)
Query: 1 MKDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQ-DNQLCMEEAMNSSHDKKQ 59
+K E +R ++ SL + L + ++N K + L+ +NQ ME + K++
Sbjct: 30 LKKEKQQRQFQLDSLEAALQKQKQKVENE----KTEGTNLKRENQRLMEICESLEKTKQK 85
Query: 60 -AQALAFEESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSIL 118
+ L +ES+V F QL KK++ L+QEL+ EL+ S +
Sbjct: 86 ISHELQVKESQVNFQEG------QLNSGKKQIEKLEQELKRCKSELERSQQAA------- 132
Query: 119 EKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLH---LAQEQLALAGDKIASLE 175
Q++D+ L + C NT +K+ L Q +G K L
Sbjct: 133 --QSADVSL--NPC-------------------NTPQKIFTTPLTPSQY-YSGSKYEDL- 167
Query: 176 RSLNLYRDKYQSSLSNIELLECQVKMLQGELGG-IMGQEPENKGDHSKVRIYTSPCMIQE 234
++KY + + LE +VK LQ + + Q N D ++ + +S Q+
Sbjct: 168 ------KEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQ 221
Query: 235 HQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYP 294
++T LS Q+ + D ++ E+E + A +
Sbjct: 222 -EKTPSHLSSNSQRTPIRRDF---------SASYFSGEQEVTPSRSTLQIGKRDANSSFF 271
Query: 295 PSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLE 354
+SS HL +Q +Q +E +N + +L + L+ ++ + + +L+
Sbjct: 272 DNSSS---------PHLLDQLKAQ---NQELRNKINELELRLQGHEKEMKGQVNKFQELQ 319
Query: 355 LDLHGLREE-----------------TSAHIERKDKDITILQCRLQELQLEFTETQKLTL 397
L L + E T+A ++ T L+ +L++L T+ L+
Sbjct: 320 LQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKL------TEDLSC 373
Query: 398 KKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELE--KQQCMATELEMTVKEAKQDKSK- 454
++ + + Q++++K + Q L ++++ + Q+C+ + +T +E +Q K+
Sbjct: 374 QRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLT-QELQQAKNMH 432
Query: 455 ---EAECKALQAEVQKLKNSLEEAKQQERLAAQ--QAAQCKEEAALAGCHLEDTQRKLQK 509
+AE L + Q+L+N+LEE KQ+ A Q QA+Q KE + L K
Sbjct: 433 NVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLK 492
Query: 510 GLLLDKQKADTIQELQREL----QMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLEN 565
+QKA + L+ EL Q L + + AE+ + N + E + +L E + + EN
Sbjct: 493 S--HSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQ-ETMLRDLQEKINQQEN 549
Query: 566 S-------------DKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEA 612
S +K++ Q + +++ + + D++ +E ++ LE +E
Sbjct: 550 SLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEY 609
Query: 613 TKLLEDKREQLKKSKEHEKL---MEGELEALRQEFKKKDKTLK----------ENSRKLE 659
+L E+K E+EKL ME E E L+ + + LK E R LE
Sbjct: 610 EELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLE 669
Query: 660 EENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNK--EIALQK-----ESLMSLQAQLD 712
+ ENL E++ L+S + T + +L + E + QK E++ +QL
Sbjct: 670 MDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLT 729
Query: 713 KALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEK 772
++ +H LQ ++ E D C DL E L + KS SL ++
Sbjct: 730 GQVEDLEHKLQ-LLSNEIMD-----KDRCYQDLHAEYESLRDL---LKSKDASLVTNEDH 780
Query: 773 KAQL--EEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQV------LQ 824
+ L ++ A + E + E LE K + +V L+
Sbjct: 781 QRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLE 840
Query: 825 WQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGND 884
QKQ +DL ++Q E + ++ENL++ ++ + Q V + + R+ +
Sbjct: 841 SQKQMNSDL------QKQCEELVQIKGEIEENLMKAEQ----MHQSFVAETSQRISKLQ- 889
Query: 885 QIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIE 944
E + Q V E L + L + K + L+ + + + + L++ N L+ ++
Sbjct: 890 ------EDTSAHQNVVAETL-SALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLK 942
Query: 945 EKKMKAENTRLCTKAL 960
E ++ +E L K +
Sbjct: 943 ELQLLSETLSLEKKEM 958
Score = 89.7 bits (221), Expect = 1e-17
Identities = 156/753 (20%), Positives = 315/753 (41%), Gaps = 129/753 (17%)
Query: 294 PPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKL 353
P + ++ ++++ L L+++K + ++ + ++ + ++E + N+ ++ +L
Sbjct: 13 PTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRL 72
Query: 354 ELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKK--DKFLQEKDEMLQ 411
+++ E+T I + +++E Q+ F E Q + KK +K QE
Sbjct: 73 -MEICESLEKTKQKISH--------ELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKS 123
Query: 412 ELEKKLTQVQNSLLKKEKELEKQQCMATEL---------------EMTVKEAKQDKSKEA 456
ELE+ Q++ + Q+ T L E KE ++ K EA
Sbjct: 124 ELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEA 183
Query: 457 ECKALQAEVQKLKNSLEEAKQQER-LAAQQAAQC--KEEAALAGCHLEDTQRK------- 506
E KALQA +K +L +A R +A QA+ + HL ++
Sbjct: 184 EVKALQA--KKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDF 241
Query: 507 -----------------LQKGL---------------LLDKQKADTIQELQRELQMLQKE 534
LQ G LLD+ KA QEL+ ++ L+
Sbjct: 242 SASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQN-QELRNKINELELR 300
Query: 535 SSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQ 594
EKE + +EL L+L +A K+E +KEK K D L R Q
Sbjct: 301 LQGHEKEMKGQVNKFQELQLQLEKA--KVELIEKEKVL---------NKCRDELVRTTAQ 349
Query: 595 HREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKEN 654
+ + + LE+ L+ KL ED Q + ++ +E +++ +EF+++ + +
Sbjct: 350 YDQASTKYTALEQKLK---KLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRS 406
Query: 655 SRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKA 714
+ L++E ++A L + +L+ + N +N Q + L + +L + +L +A
Sbjct: 407 FQTLDQECIQMKARL---TQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRA 463
Query: 715 LQK-EKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQ--- 770
Q + ++ + + + + +++ + Q ++ H+ +E K+++Q L Q+Q
Sbjct: 464 EQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFA 523
Query: 771 -EKKAQ----------LEEEIIAYE-----ERMKKLNTELRKLRGFHQESELEVHAFDKK 814
E KA+ L+E+I E E++K +L K R Q+ + +
Sbjct: 524 EEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDL---LKKREHH 580
Query: 815 LEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPK 874
+E+++ ++ + +K+ + L L K+++ E +EE E++K L Q K
Sbjct: 581 IEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEK---LLTQMESEK 637
Query: 875 DTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVM--VHL 932
+ + + +LE K Q++ + + ++R LS E +LH+V+ +
Sbjct: 638 ENLQ------SKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSV 691
Query: 933 QQENKKL-------KKEIEEKKMKAENTRLCTK 958
+ E +KL K E ++K + E +C K
Sbjct: 692 EVETQKLAYMELQQKAEFSDQKHQKEIENMCLK 724
Score = 84.0 bits (206), Expect = 7e-16
Identities = 193/924 (20%), Positives = 374/924 (40%), Gaps = 153/924 (16%)
Query: 22 LQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEESEVEFGSS----KQ 77
L + ++L D+ K + +L N+ + + D++ A +F E GS +
Sbjct: 756 LHAEYESLRDLLKSKDASLVTNEDHQRSLL--AFDQQPAMHHSFANIIGEQGSMPSERSE 813
Query: 78 CHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLHHHCKLKED 137
C L + Q K +LQ ++ L+ S S +Q S L+KQ +LV + E+
Sbjct: 814 CRL-EADQSPKNSAILQNRVD----SLEFSLESQKQMNSDLQKQCEELVQIKGEI---EE 865
Query: 138 EVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASL-------ERSLNLYRDKYQSSLS 190
++ E+ + T +++ QE + + +A E+ L L DK ++ +
Sbjct: 866 NLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQA 925
Query: 191 NIELLECQVKMLQGELGGIMGQEPE---NKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQ 247
I+ L+ +L+ L + K + S + I + I+E + L E+
Sbjct: 926 EIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSI-ISLNKREIEELTQENGTLKEINA 984
Query: 248 KVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFAS--------CTATHRYPPSSSE 299
++Q+ L K + EREK++ +L + C T
Sbjct: 985 SLNQEK---MNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEET-------GN 1034
Query: 300 ECEDIKKILKHLQEQKDS-QCLHVEEYQNLVKDLRVELEAVSE----------------Q 342
ED+ + K QE+ +CL + E +L ++ + ELE + E +
Sbjct: 1035 AYEDLSQKYKAAQEKNSKLECL-LNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAE 1093
Query: 343 KRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKF 402
+RN M++LE LR E + + + L+ + L+ E + QK + +
Sbjct: 1094 ERN-QNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQK---EVNDL 1149
Query: 403 LQEKDEMLQELEKK-------LTQVQNSLLKKEKELEKQQC-MATELEMTVKEAK----- 449
LQE +++++ ++ K ++NS+ KE+E E+ QC ++++ VKE
Sbjct: 1150 LQENEQLMKVMKTKHECQNLESEPIRNSV--KERESERNQCNFKPQMDLEVKEISLDSYN 1207
Query: 450 -----------------QDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEE 492
Q+ KE EC LQ E+Q ++ LE + Q+ Q +E
Sbjct: 1208 AQLVQLEAMLRNKELKLQESEKEKEC--LQHELQTIRGDLETSNLQDM-------QSQEI 1258
Query: 493 AALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEEL 552
+ L C ++ ++ + L + D LQ LQ + + EK E L
Sbjct: 1259 SGLKDCEIDAEEKYISGPHELSTSQNDNAH-LQCSLQTTMNKLNELEKI-------CEIL 1310
Query: 553 SLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEA 612
E E + +L +S E + +AE+ + +L+ +K + + G + +L ED+
Sbjct: 1311 QAEKYELVTELNDSRSECITATRKMAEE---VGKLLNEVKILNDDSGLLHGELVEDIPGG 1367
Query: 613 TKLLEDKREQ-------LKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENL 665
+ E EQ L +S +E L DK ++ + +L+E+ +L
Sbjct: 1368 -EFGEQPNEQHPVSLAPLDESNSYEHLT------------LSDKEVQMHFAELQEKFLSL 1414
Query: 666 RAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKE-KHYLQT 724
++E + Q +K + Q + L E + +L + Q L K +Q + L
Sbjct: 1415 QSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVP 1474
Query: 725 TITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIA-- 782
+++ S S+ +AL + S +L+ +++ Q ++E +
Sbjct: 1475 SLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQ---CSVDEVFCSSL 1531
Query: 783 YEERMKKLNTELRKLRGFHQ-ESELEVH--AFDKKLEEMSCQVLQWQKQHQNDLKMLAAK 839
EE + + T +G + ES EV+ + +K E+M Q + K+ Q +L+ L +
Sbjct: 1532 QEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQ-ELEQLLSS 1590
Query: 840 EEQLREFQEEMAALKENLLEDDKE 863
E Q E+ L++ L ++++
Sbjct: 1591 ERQ------ELDCLRKQYLSENEQ 1608
Score = 82.8 bits (203), Expect = 1e-15
Identities = 206/1049 (19%), Positives = 407/1049 (38%), Gaps = 151/1049 (14%)
Query: 3 DEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQA 62
++ ++ + NSKL L + +L C+ ++ L+ ++EA H + +
Sbjct: 1037 EDLSQKYKAAQEKNSKLECLLNECTSL---CENRKNELEQ----LKEAFAKEHQEFLTK- 1088
Query: 63 LAFEESEVEFGSSKQCHLRQLQQ-LKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQ 121
LAF E E + L +QQ L+ ++ Q + L+ +L++ Q+ ++K+
Sbjct: 1089 LAFAE---ERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKE 1145
Query: 122 TSDLVLLH----------HHCKLKEDEVI---LYEEEMGNHNENTGEKLHLAQEQLALAG 168
+DL+ + H C+ E E I + E E + N ++ L ++++L
Sbjct: 1146 VNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDS 1205
Query: 169 --DKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIY 226
++ LE L K Q S E L+ +++ ++G+L E N D I
Sbjct: 1206 YNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDL------ETSNLQDMQSQEIS 1259
Query: 227 -TSPCMIQEHQETQKRLSEVWQKVSQQDDL-----IQELRNKL----ACSNALVLEREKA 276
C I ++ E+ SQ D+ +Q NKL L E+ +
Sbjct: 1260 GLKDCEIDAEEKYISGPHEL--STSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYEL 1317
Query: 277 LIKLQADFASC-TATHRYPPSSSEECEDIKKILKHLQE-QKDSQCLHVE----------- 323
+ +L + C TAT + E++ K+L ++ DS LH E
Sbjct: 1318 VTELNDSRSECITATRKM-------AEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFG 1370
Query: 324 ------------------EYQNL-VKDLRVELEAVSEQKRNI-MKDMMKLELDLH----G 359
Y++L + D V++ Q++ + ++ K+ D H
Sbjct: 1371 EQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSS 1430
Query: 360 LREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQ 419
E +++ + +L L+ Q + + +L L++ + + +
Sbjct: 1431 KMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSL 1490
Query: 420 VQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNS-------L 472
+S + E + + LE V A Q E C +LQ E K + +
Sbjct: 1491 GDSSFYRALLEQTGDMSLLSNLEGAVS-ANQCSVDEVFCSSLQEENLTRKETPSAPAKGV 1549
Query: 473 EEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTI--QELQRELQM 530
EE + + Q + +E+ G ++L++ L ++Q+ D + Q L Q
Sbjct: 1550 EELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQW 1609
Query: 531 LQKESSMA---EKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDM 587
QK +S+ E + + +K+ E+LSLEL A +L+ D R L E ++ +
Sbjct: 1610 QQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNE 1669
Query: 588 LDRIKHQHREQGSIKCK-------LEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEAL 640
I +H + + + ++D Q+ L +K + K + +
Sbjct: 1670 SCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDT 1729
Query: 641 RQEFKKKDKT--LKENSRKLEEENENLRAELQCCSTQ---------LESSLNKYNTSQQV 689
E +DKT E +L N + Q ++ + N+ V
Sbjct: 1730 NYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHV 1789
Query: 690 IQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQAL 749
I+D ++++ ESL++ +LD L ++ L T I EA L + + + +
Sbjct: 1790 IEDRDRKV----ESLLNEMKELDSKLHLQEVQLMTKI--EACIELEKIVGELKKENSDLS 1843
Query: 750 EKLNHVTSETKSLQQSLTQTQEKKAQLE--------EEI--------IAYEERMKKLNTE 793
EKL + + + + L Q + ++ + LE E+I +++ER + E
Sbjct: 1844 EKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENE 1903
Query: 794 LRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAAL 853
L ++R E E + LE + + L +K ++N K++ EE+L E L
Sbjct: 1904 LSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQL 1963
Query: 854 KENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVK 913
+ L K+ L Q S ++ ++ ++ + +VA +++E+ +
Sbjct: 1964 RGELDTMSKKTTALDQLSE-----KMKEKTQELESHQSECLHCIQVAEA----EVKEKTE 2014
Query: 914 YIAKLSGEKDHLHSVMVHLQQENKKLKKE 942
+ LS + L HLQ++ + L+K+
Sbjct: 2015 LLQTLSSDVSELLKDKTHLQEKLQSLEKD 2043
Score = 82.0 bits (201), Expect = 3e-15
Identities = 152/777 (19%), Positives = 310/777 (39%), Gaps = 139/777 (17%)
Query: 243 SEVWQKVSQQDDLIQELRNKLAC----SNALVLEREKALIKLQA-DFASCTA----THRY 293
+E WQ+ + + E+ +KLA + L LE E A ++LQ D +S + T
Sbjct: 1606 NEQWQQ--KLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDA 1663
Query: 294 PPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSE------------ 341
+E C+ K+ E+ +H ++ +DL +++E ++E
Sbjct: 1664 IQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSG 1723
Query: 342 ------------QKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEF 389
+ + EL G +DI LQ R++
Sbjct: 1724 EQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVK------ 1777
Query: 390 TETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAK 449
ET L+ ++++D ++ L ++ ++ + L +E +L + ELE V E K
Sbjct: 1778 -ETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELK 1836
Query: 450 QDKSKEAE-CKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEE------AALAGCHLE- 501
++ S +E + + Q+L +E ++ A + E A + E
Sbjct: 1837 KENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKER 1896
Query: 502 --DTQRKLQKGLLLDKQKADTIQE---LQRELQMLQKESSMAEKEQTSNRKRVEELSLEL 556
D + +L + + +KA E L+ +L+++Q E EK+ + +K + L EL
Sbjct: 1897 FLDVENELSR---IRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEEL 1953
Query: 557 SEALRKLENSDKEKRQLQ---KTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEAT 613
S E+ QL+ T++++ ++ + +++K + +E LE E
Sbjct: 1954 SVV-------TSERNQLRGELDTMSKKTTALDQLSEKMKEKTQE-------LESHQSECL 1999
Query: 614 KLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKT-LKENSRKLEEENENLRAELQCC 672
++ ++K+ E + + ++ L KDKT L+E + LE++++ L
Sbjct: 2000 HCIQVAEAEVKEKTELLQTLSSDVSEL-----LKDKTHLQEKLQSLEKDSQAL------- 2047
Query: 673 STQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKA---------------LQK 717
SL K Q+ Q LNKE L + SLQA+L ++ ++K
Sbjct: 2048 ------SLTKCELENQIAQ-LNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEK 2100
Query: 718 EKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLE 777
+ L+ + T+E L R + + +K H+ + K ++ ++K LE
Sbjct: 2101 GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLE 2160
Query: 778 EEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLA 837
E+ EE + + + + + + ++ + L+ ++ + + +N K +
Sbjct: 2161 RELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQ 2220
Query: 838 AKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQ 897
K+ QL E + +++ K L E ++ Q ++
Sbjct: 2221 EKQGQLSELDKLLSSFKSLLEEKEQAEI--------------------------QIKEES 2254
Query: 898 KVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQ---QENKKLKKEIEEKKMKAE 951
K A E L NQL+E + +A L G+++ + + L +E +L+ IE+ + + E
Sbjct: 2255 KTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLE 2311
Score = 39.7 bits (91), Expect = 0.014
Identities = 61/264 (23%), Positives = 102/264 (38%), Gaps = 40/264 (15%)
Query: 1 MKDEAGERDREVSSLNSKLLSLQLDIKNLHDV-CKRQRKTLQDNQLCME------EAMNS 53
+++E E + K +L LD ++V + R+ L + C+ + + S
Sbjct: 2692 VREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKS 2751
Query: 54 SHDKKQAQALAFEESEVEFGSSKQCHLRQLQQLKK-------KLLVLQQELEFHTEELQT 106
S ++ A + E +K +L+ + QLKK K+ +L + + EE +
Sbjct: 2752 SKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEI 2811
Query: 107 SYYSLRQYQSILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLAL 166
L Q Q+ EKQ + V+ K DE+ +E+ E EK A E
Sbjct: 2812 LQKELSQLQAAQEKQKTGTVM-----DTKVDELTTEIKEL---KETLEEKTKEADE---- 2859
Query: 167 AGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIY 226
Y DKY S L + E LE +ML+ ++ + Q+ + S +
Sbjct: 2860 --------------YLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSRGSPLLGP 2905
Query: 227 TSPCMIQEHQETQKRLSEVWQKVS 250
P T+KRLS K S
Sbjct: 2906 VVPGPSPIPSVTEKRLSSGQNKAS 2929
Score = 31.2 bits (69), Expect = 5.1
Identities = 36/158 (22%), Positives = 72/158 (45%), Gaps = 19/158 (12%)
Query: 810 AFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEM--AALKENLLEDDKEPCCL 867
A ++ E + + LQ ++ + L L KE+Q R+FQ + AAL++ + + E
Sbjct: 4 ALEEWKEGLPTRALQKIQELEGQLDKLK-KEKQQRQFQLDSLEAALQKQKQKVENEKT-- 60
Query: 868 PQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHS 927
+ L R N ++M E K + +K+ ++L+ + + G+ +
Sbjct: 61 -------EGTNLKRENQRLMEICESLEKTK----QKISHELQVKESQVNFQEGQLNSGKK 109
Query: 928 VMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRT 965
+ L+QE K+ K E+E + A++ + +L P T
Sbjct: 110 QIEKLEQELKRCKSELERSQQAAQSADV---SLNPCNT 144
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 138 bits (347), Expect = 3e-32
Identities = 207/953 (21%), Positives = 414/953 (43%), Gaps = 106/953 (11%)
Query: 21 SLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALA----FEESEVEFG-SS 75
SL+ + K D+ + +RK D ++ E M+ +DK+Q + FE S+++
Sbjct: 1041 SLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDD 1100
Query: 76 KQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLHHHCKLK 135
+Q H Q Q KK+ LQ +E EE++ + ++ +EKQ SDL +
Sbjct: 1101 EQVHSLQFQ---KKIKELQARIEELEEEIEAEH----TLRAKIEKQRSDLARELEEISER 1153
Query: 136 EDEV---ILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERS--------LNLYRDK 184
+E + EM E +K+ E+ L + A+ R L D
Sbjct: 1154 LEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDN 1213
Query: 185 YQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSE 244
Q +E + ++KM ++ + ++K + + C E Q SE
Sbjct: 1214 LQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERT------CRTVEDQ-----FSE 1262
Query: 245 VWQKVSQQDDLIQEL---RNKLACSNA----LVLEREKALIKLQADFASCTATHRYPPSS 297
+ K QQ LI +L + +L N V E+E + +L + T
Sbjct: 1263 IKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQ 1322
Query: 298 SEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELE-AVSEQKRNIMKDMMKLELD 356
EE K + H + C + E ++ + EL+ A+S+ + + K E D
Sbjct: 1323 MEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETD 1382
Query: 357 LHGLREETSAHIERKDKDITILQCRLQELQLEFTETQK-----LTLKKDKFLQEKDEMLQ 411
EE E K K L RLQE + E TET L K + E +++++
Sbjct: 1383 AIQRTEELE---EAKKK----LAQRLQEAE-ENTETANSKCASLEKTKQRLQGEVEDLMR 1434
Query: 412 ELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQD-KSKEAECKALQAEVQKLKN 470
+LE+ T +L KK++ +K + E + + E++ + ++ + E ++L E+ K++N
Sbjct: 1435 DLERSHTACA-TLDKKQRNFDK---VLAEWKQKLDESQAELEAAQKESRSLSTELFKMRN 1490
Query: 471 SLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQM 530
+ EE Q ++ +EE + + +T + LQ+ ++ +++ + +LQ+
Sbjct: 1491 AYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEA----EKTKKLVEQEKSDLQV 1546
Query: 531 LQKESSMAEKEQTSNRKRVE-ELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLD 589
+E + + + S RV+ ELS SE RK+ D+E QL++ + +LD
Sbjct: 1547 ALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLD 1606
Query: 590 RIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALR---QEFKK 646
+ +K K+E DL E L Q+ ++++H + ++G+L+ + + +
Sbjct: 1607 AEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALR 1666
Query: 647 KDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIAL---QKES 703
++ LKE +E N L EL+ LE + S+Q + D + + L Q S
Sbjct: 1667 SNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTS 1726
Query: 704 LMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQD------DLTQALEKLNHVTS 757
L++ + +L+ + + + ++ +I +E+ +A + A D +L + + H+
Sbjct: 1727 LINTKKKLEADIAQCQAEVENSI-QESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1785
Query: 758 ETKSLQQSLTQTQEKKAQLEE--------EIIAYEERMKKLNTELRKLRGFHQESELEVH 809
K+L+Q++ Q + + E+ +I E R+++L EL + E+ H
Sbjct: 1786 MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAH 1845
Query: 810 AFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQ 869
+++K++EM+ Q ++ H+N L++ ++ + + Q ++ + K E ++ Q
Sbjct: 1846 KYERKVKEMTYQA---EEDHKNILRL----QDLVDKLQAKVKSYKRQAEEAEE------Q 1892
Query: 870 WSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEK 922
+ CR ++ LE+ A++ +A ++ N+LR + + + E+
Sbjct: 1893 ANTQLSRCR------RVQHELEEAAERADIAESQV-NKLRAKSRDVGSQKMEE 1938
Score = 132 bits (332), Expect = 2e-30
Identities = 215/1036 (20%), Positives = 447/1036 (43%), Gaps = 147/1036 (14%)
Query: 4 EAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSH-DKKQAQA 62
E ER E +NS+L++ + +NL D C ++ + D +L + + H + + +
Sbjct: 925 ELTERLEEEEEMNSELVAKK---RNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKN 981
Query: 63 LAFEESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQT 122
L+ E + +E SK L + KK L Q+ + + L + + LE+QT
Sbjct: 982 LSEEMTALEENISK------LTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQT 1035
Query: 123 SDLV-LLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLY 181
DL L KL+ D L + + L GD S E ++L
Sbjct: 1036 DDLEGSLEQEKKLRAD---------------------LERAKRKLEGDLKMSQESIMDLE 1074
Query: 182 RDKYQSSLSNIELLECQVKMLQGELGG--IMGQEPENKGDHSKVRIYTSPCMIQ-EH--- 235
DK Q ++ E ++ LQ ++ + + + K + RI I+ EH
Sbjct: 1075 NDKQQIE-EKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLR 1133
Query: 236 QETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPP 295
+ +K+ S++ +++ + + ++E + + +RE K++ D T H
Sbjct: 1134 AKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1193
Query: 296 SS-----SEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDM 350
++ ++ ++ + + +LQ K E + + D+ +EA+S+ K NI +
Sbjct: 1194 ATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTC 1253
Query: 351 MKLELDLHGLREETSAHIERKDK-------DITILQCRLQ----ELQLEFTETQKLTLKK 399
+ E+ + I+ KD+ D+ + + RLQ EL E + L +
Sbjct: 1254 RTV--------EDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQL 1305
Query: 400 DKFLQEKDEMLQELEKKL---TQVQNSL------------LKKEKELEKQQCMATELEMT 444
K Q + L+EL++++ T+ +N++ L +E+ E+Q+ A EL+
Sbjct: 1306 TKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKA-ELQRA 1364
Query: 445 VKEAKQDKSK---EAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLE 501
+ +A + ++ + E A+Q LEEAK++ Q+A + E A LE
Sbjct: 1365 LSKANSEVAQWRTKYETDAIQR-----TEELEEAKKKLAQRLQEAEENTETANSKCASLE 1419
Query: 502 DTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALR 561
T+++LQ +++L R+L+ + +K+Q + K + E +L E+
Sbjct: 1420 KTKQRLQ----------GEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQA 1469
Query: 562 KLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEE----------DLQE 611
+LE + KE R L + + +++D+++ RE +++ ++ + +LQE
Sbjct: 1470 ELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQE 1529
Query: 612 A---TKLLEDKR-------EQLKKSKEHE--KLMEGELEALRQEFKKKDKTLKENSRKLE 659
A KL+E ++ E+++ S EHE K++ +LE L Q + D+ + E ++E
Sbjct: 1530 AEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLE-LSQVKSELDRKVIEKDEEIE 1588
Query: 660 EENENLRAELQCCSTQLESSLNKYNTS----QQVIQDLNKEIALQKESLMSLQAQLDKAL 715
+ N + + + L++ + N + +++ DLN E+ +Q A+ K L
Sbjct: 1589 QLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLN-EMEIQLGHSNRQMAETQKHL 1647
Query: 716 QKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQ 775
+ + L+ ++ D R + ++ L + + E + ++ +L QT+ +
Sbjct: 1648 RTVQGQLKD--SQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRL 1705
Query: 776 LEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLE---EMSCQVLQWQKQHQND 832
E+E++ +R++ L+++ L ++ E ++ ++E + S + K+ D
Sbjct: 1706 SEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITD 1765
Query: 833 LKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIM---TN 889
M+A + ++ ++ + +K+NL + K+ L + L G QI
Sbjct: 1766 AAMMAEELKKEQDTSAHLERMKKNLEQTVKD---LQHRLDEAEQLALKGGKKQIQKLENR 1822
Query: 890 LEQWAKQQKVANEKLGNQLREQVKYIAKL-----SGEKDH-----LHSVMVHLQQENKKL 939
+ + + V ++ L+ KY K+ E+DH L ++ LQ + K
Sbjct: 1823 VRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSY 1882
Query: 940 KKEIEEKKMKAENTRL 955
K++ EE + +A NT+L
Sbjct: 1883 KRQAEEAEEQA-NTQL 1897
Score = 124 bits (311), Expect = 4e-28
Identities = 207/960 (21%), Positives = 400/960 (41%), Gaps = 132/960 (13%)
Query: 67 ESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQ----T 122
E+E E + K+ R ++L + E +EL+ SL Q ++ L+ Q T
Sbjct: 848 EAEKEMATMKEDFERTKEELARS--------EARRKELEEKMVSLLQEKNDLQLQVQSET 899
Query: 123 SDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAG---DKIASLERSLN 179
+L+ C+ IL E ++ E E+ + E +A DK +SL+R +
Sbjct: 900 ENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDI- 958
Query: 180 LYRDKYQSSLSNIE----LLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCM---- 231
D + +L+ +E E +VK L E+ + +E +K K + +
Sbjct: 959 ---DDLELTLTKVEKEKHATENKVKNLSEEMTAL--EENISKLTKEKKSLQEAHQQTLDD 1013
Query: 232 IQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATH 291
+Q ++ L ++ K+ QQ D +L L L + E+A KL+ D +
Sbjct: 1014 LQVEEDKVNGLIKINAKLEQQTD---DLEGSLEQEKKLRADLERAKRKLEGDLKMSQESI 1070
Query: 292 RYPPSSSEECED-IKKI---LKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQ----- 342
+ ++ E+ +KK L LQ + D + +H ++Q +K+L+ +E + E+
Sbjct: 1071 MDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEH 1130
Query: 343 --KRNIMKDMMKLELDLHGLREE-------TSAHIE---RKDKDITILQCRLQELQLEFT 390
+ I K L +L + E TSA IE +++ + ++ L+E L+
Sbjct: 1131 TLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQH- 1189
Query: 391 ETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQ 450
E TL+K ++ + + EL +++ +Q K EKE + + ++ ++ +
Sbjct: 1190 EATAATLRK-----KQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSK 1244
Query: 451 DKSK-EAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQK 509
KS E C+ ++ + ++K E+ Q Q A+ + + +E+ + + +
Sbjct: 1245 SKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQ 1304
Query: 510 GLLLDKQKADTIQELQRELQMLQK-ESSMAEKEQTSN------RKRVEELSLELSEALRK 562
+ ++EL+R+++ K +++MA Q+S R++ EE +E R
Sbjct: 1305 LTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRA 1364
Query: 563 LENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQ 622
L ++ E Q + ++ + L+ K KL + LQEA + E +
Sbjct: 1365 LSKANSEVAQWRTKYETDAIQRTEELEEAKK----------KLAQRLQEAEENTETANSK 1414
Query: 623 LKKSKEHEKLMEGELEALRQEFKKK--------------DKTLKENSRKLEEENENLRA- 667
++ ++ ++GE+E L ++ ++ DK L E +KL+E L A
Sbjct: 1415 CASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAA 1474
Query: 668 --ELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTT 725
E + ST+L N Y ++ L +E +E + L Q+ + K+ +
Sbjct: 1475 QKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQI---AETGKNLQEAE 1531
Query: 726 ITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEE 785
TK+ + ++ + Q L + L H S+ +Q L+Q K++L+ ++I +E
Sbjct: 1532 KTKKLVE---QEKSDLQVALEEVEGSLEHEESKILRVQLELSQV---KSELDRKVIEKDE 1585
Query: 786 RMKKLNTE-------LRKLRGFHQESELEVHAFDKKLE----EMSCQVLQWQKQHQNDLK 834
+++L L+ + S + KK+E EM Q+ +Q K
Sbjct: 1586 EIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQK 1645
Query: 835 MLAAKEEQLREFQEEMA-ALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQW 893
L + QL++ Q + AL+ N ED KE + + R N ++ LE+
Sbjct: 1646 HLRTVQGQLKDSQLHLDDALRSN--EDLKEQLAIVE-----------RRNGLLLEELEE- 1691
Query: 894 AKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAENT 953
KVA E+ R + + S LHS L KKL+ +I + + + EN+
Sbjct: 1692 ---MKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENS 1748
Score = 89.0 bits (219), Expect = 2e-17
Identities = 99/424 (23%), Positives = 187/424 (44%), Gaps = 34/424 (8%)
Query: 534 ESSMAEKEQTSNRKRVEELSLEL--SEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRI 591
+S+ AEKE + ++ E EL SEA RK E +K LQ+ Q ++ + +
Sbjct: 845 KSAEAEKEMATMKEDFERTKEELARSEARRK-ELEEKMVSLLQEKNDLQLQVQSETENLM 903
Query: 592 KHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTL 651
+ R +G IK K+ LLE K ++L + E E+ M EL A ++ + K +L
Sbjct: 904 DAEERCEGLIKSKI---------LLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSL 954
Query: 652 KENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQL 711
K + LE + E ++++ + ++ I L KE K+SL Q
Sbjct: 955 KRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKE----KKSLQEAHQQT 1010
Query: 712 DKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSET----KSLQQSLT 767
LQ E+ + I ++ K DDL +LE+ + ++ + L+ L
Sbjct: 1011 LDDLQVEEDKVNGLIK------INAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLK 1064
Query: 768 QTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQK 827
+QE LE + EE++KK EL +L+ + ++ F KK++E+ ++ + ++
Sbjct: 1065 MSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEE 1124
Query: 828 QHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIM 887
+ + + + A E+Q + E+ + E L E + + ++ ++
Sbjct: 1125 EIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREA-----EFQKMR 1179
Query: 888 TNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKK 947
+LE+ Q + L ++Q +A+L + D+L V L++E +LK EI++
Sbjct: 1180 RDLEEATLQHEATAATL---RKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMA 1236
Query: 948 MKAE 951
E
Sbjct: 1237 SNIE 1240
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 137 bits (345), Expect = 5e-32
Identities = 219/1109 (19%), Positives = 452/1109 (40%), Gaps = 176/1109 (15%)
Query: 2 KDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKR--QRKTLQDNQLCMEEAMNSSHDKKQ 59
++E ++ E+ + + ++K L + + K L QL E + + ++ +
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910
Query: 60 AQALAFEESEVEFGSSKQCHL-------RQLQQLKKKLLVLQQELEFHTEELQTSYYSLR 112
+ A ++ E + L +QLQ +KK+ +LE EE + + L+
Sbjct: 911 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 970
Query: 113 QYQSILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIA 172
LEK T++ + K EDE+++ +++ N ++ L +E+++ +A
Sbjct: 971 -----LEKVTAEAKI-----KKLEDEILVMDDQ----NNKLSKERKLLEERISDLTTNLA 1016
Query: 173 SLE---RSLNLYRDKYQSSLSNIEL-----------LECQVKMLQGELGGIMGQEPENKG 218
E ++L ++K++S +S +E+ LE + L+G+ Q + +
Sbjct: 1017 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 219 DHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQD--------------DLIQELRNKLA 264
+++++ + ++ +E Q L+ + +++Q++ DL ++L ++ A
Sbjct: 1077 QIAELKMQ----LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1132
Query: 265 CSNALVLEREKALIKLQA------DFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQ 318
N ++ +L+A D TAT + + E+ ++ + K L E+ S
Sbjct: 1133 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ--EVTVLKKALDEETRSH 1190
Query: 319 CLHVEE----YQNLVKDLRVELEAVSEQKRNIMKDMMKLE---LDLHG---LREETSAHI 368
V+E + V++L +LE K N+ K+ LE DL G + + +
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250
Query: 369 ERKDKDITILQCRLQELQ------------------------------LEFTETQKLTLK 398
E K K L+ ++QELQ L E + + L
Sbjct: 1251 EHKKKK---LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307
Query: 399 KD-----KFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKS 453
KD LQ+ E+LQE ++ V L + E+E Q E EM EAKQ+
Sbjct: 1308 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE-EM---EAKQNLE 1363
Query: 454 KEAECKALQAEVQKLK--------NSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQR 505
+ +Q K K +LEE K++ + + Q EE A A LE T+
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1423
Query: 506 KLQK---GLLLD----KQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVE----ELSL 554
+LQ+ L++D +Q +++ QR+ L E + R R E E
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1483
Query: 555 ELSEALRKLENSDKEKRQLQKTVAEQDMKMNDML---DRIKHQHREQGSIKCKLEEDLQE 611
+ R LE + + K +L++T +M D++ D + E K LE ++E
Sbjct: 1484 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1543
Query: 612 ATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQC 671
LE+ ++L+ +++ + +E ++AL+ +F ++ L+ + EE+ L+ +L
Sbjct: 1544 MKTQLEELEDELQATEDAKLRLEVNMQALKGQF---ERDLQARDEQNEEKRRQLQRQLHE 1600
Query: 672 CSTQLESSLNKYNTSQQVIQDLN---KEIALQKES-----------LMSLQAQL------ 711
T+LE + + + L K++ LQ +S L LQAQ+
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660
Query: 712 --DKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQT 769
D +++ + ++ +L Q+DL A E + L + L +
Sbjct: 1661 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1720
Query: 770 QEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQH 829
+ L++E E R+ +L EL + +G + V ++ E++S ++ +
Sbjct: 1721 LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTA 1780
Query: 830 QNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTN 889
Q + E Q +E + ++ ++ + K + + Q+
Sbjct: 1781 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA-----------QLEEQ 1829
Query: 890 LEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQEN---KKLKKEIEEK 946
+EQ A++++ A + L + ++ + + ++ E+ ++ N K+LK+++EE
Sbjct: 1830 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEA 1889
Query: 947 KMKAENTRLCTKALGPSRTESTQREKVCG 975
+ +++ + L E+T+ + G
Sbjct: 1890 EEESQRINANRRKLQRELDEATESNEAMG 1918
Score = 129 bits (325), Expect = 1e-29
Identities = 196/960 (20%), Positives = 411/960 (42%), Gaps = 109/960 (11%)
Query: 81 RQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLHH-HCKLKEDEV 139
R ++K L V +QE EE+Q L++ + +K ++L L H +L E++
Sbjct: 836 RLFTKVKPLLQVTRQE-----EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKN 890
Query: 140 ILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQV 199
+L +E++ E E A+E K LE L+ + + + L+ +
Sbjct: 891 LL-QEQLQAETELYAE----AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAER 945
Query: 200 KMLQGELGGIMGQEPENKGDHSKVRI--YTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQ 257
K + ++ + Q E + K+++ T+ I++ ++ + + K+S++ L++
Sbjct: 946 KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1005
Query: 258 ELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDS 317
E + L + A E+ K L KL+ S I ++ L++++ S
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESM----------------ISELEVRLKKEEKS 1049
Query: 318 QCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITI 377
+ +E + L + L + EQ ++ + +L++ L EE A + R D +I
Sbjct: 1050 R----QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA- 1104
Query: 378 LQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKEL-EKQQC 436
+ LKK + L+ LQE +N K++++L E+ +
Sbjct: 1105 --------------QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150
Query: 437 MATELEMTVKE--------AKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQ 488
+ TELE T+ AK+++ KAL E + + ++E +Q+ A ++ +
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1210
Query: 489 CKEEAALAGCHLEDTQRKLQKG----------LLLDKQKAD-TIQELQRELQMLQKESSM 537
E+ A +L+ ++ L+K L KQ+ + ++L+ ++Q LQ + S
Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270
Query: 538 AEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHRE 597
E+ + +V +L E+ L ++ + +L K VA ++ D + ++ + R+
Sbjct: 1271 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1330
Query: 598 QGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRK 657
+ ++ KL + L+E L+D+ ++ ++K++ + L + KKK +
Sbjct: 1331 KLNVSTKLRQ-LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1389
Query: 658 LEEENENLRAELQCCSTQLESSLNKY-------NTSQQVIQDLNKEIALQKESLMSL--- 707
LEE + + E++ + Q E Y N QQ + DL ++ Q++ + +L
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Query: 708 QAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLT 767
Q + D+ L +EK+ I+ + D R A ++ T+AL L E ++ L
Sbjct: 1450 QRKFDQLLAEEKN-----ISSKYADERDRAEAEAREKETKALS-LARALEEALEAKEELE 1503
Query: 768 QTQEK-KAQLEEEIIA----------YEERMKKLNTELRKLRGFHQESELEVHAFDKKLE 816
+T + KA++E+ + + E+ + L T++ +++ +E E E+ A +
Sbjct: 1504 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1563
Query: 817 EMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPK-- 874
+ + + Q + DL+ + E+ R + E LED+++ L + K
Sbjct: 1564 RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1623
Query: 875 -DTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQ 933
D L D + E+ KQ + KL Q+++ + + +D + +
Sbjct: 1624 GDLKDLELQADSAIKGREEAIKQLR----KLQAQMKDFQRELEDARASRDEIFAT----A 1675
Query: 934 QENKKLKKEIEEKKMK-AENTRLCTKALGPSRTESTQ-REKVCGTLGWKGLPQDMGQRMD 991
+EN+K K +E M+ E+ +A + E + E++ +L + QD +R++
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735
Score = 114 bits (284), Expect = 6e-25
Identities = 172/827 (20%), Positives = 340/827 (41%), Gaps = 113/827 (13%)
Query: 1 MKDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQA 60
+ +E + +V + K ++ + KR + L N+ +E+ ++ +
Sbjct: 1183 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK--ENADLAGEL 1240
Query: 61 QALAFEESEVEFGSSK-QCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYS----LRQYQ 115
+ L + EVE K + +++LQ + EL +LQ S L + +
Sbjct: 1241 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1300
Query: 116 SILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTG-----EKLHLAQEQLALAGDK 170
K D+ L +L++ + +L EE N +T E+ + Q+QL +
Sbjct: 1301 GKAIKLAKDVASLSS--QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1358
Query: 171 IASLER---SLNLY----RDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKV 223
+LER +LN+ + K Q S +E LE K Q E+ + Q E + K+
Sbjct: 1359 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1418
Query: 224 RIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREK--ALIKLQ 281
++T+ RL + + DDL+ +L N+ + L ++ K L+ +
Sbjct: 1419 ------------EKTKNRLQQ------ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1460
Query: 282 ADFASCTATHRYPPSSSEECEDIK--KILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAV 339
+ +S A R + ++ K + + L+E +++ EE + K L+ E+E +
Sbjct: 1461 KNISSKYADERDRAEAEAREKETKALSLARALEEALEAK----EELERTNKMLKAEMEDL 1516
Query: 340 SEQKRNIMKDMMKLELDLHGLR---EETSAHIERKDKDITILQCRLQELQLEFTETQKLT 396
K ++ K++ +LE L EE +E + ++ + L++ Q L
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM---QALK 1573
Query: 397 LKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELE---KQQCMATELEMTVKEAKQDKS 453
+ ++ LQ +DE + E+K Q+Q L + E ELE KQ+ +A A K
Sbjct: 1574 GQFERDLQARDE---QNEEKRRQLQRQLHEYETELEDERKQRALA---------AAAKKK 1621
Query: 454 KEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLL 513
E + K L+ + EEA +Q R Q + E LED + +
Sbjct: 1622 LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE-------LEDARASRDEIFAT 1674
Query: 514 DKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQL 573
K+ + L+ +L LQ++ + AE+ + EEL+ EL+ +L EKR+L
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734
Query: 574 QKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLM 633
+ +A+ LEE+L+E +E ++++K+ + + +
Sbjct: 1735 EARIAQ-------------------------LEEELEEEQGNMEAMSDRVRKATQQAEQL 1769
Query: 634 EGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQ----CCSTQLESSLNKYNTSQQV 689
EL R +K + ++LE +N+ LR++L ++ +S++
Sbjct: 1770 SNELATERSTAQKNESA----RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1825
Query: 690 IQDLNKEIALQKESLMSLQAQLDK-----ALQKEKHYLQTTITKEAYDALSRKSAACQDD 744
+++ ++ A +K++ Q DK LQ E KE + + + +
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1885
Query: 745 LTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLN 791
L +A E+ + + + LQ+ L + E + E+ A + ++++ N
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1932
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 137 bits (345), Expect = 5e-32
Identities = 219/1109 (19%), Positives = 452/1109 (40%), Gaps = 176/1109 (15%)
Query: 2 KDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKR--QRKTLQDNQLCMEEAMNSSHDKKQ 59
++E ++ E+ + + ++K L + + K L QL E + + ++ +
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917
Query: 60 AQALAFEESEVEFGSSKQCHL-------RQLQQLKKKLLVLQQELEFHTEELQTSYYSLR 112
+ A ++ E + L +QLQ +KK+ +LE EE + + L+
Sbjct: 918 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 977
Query: 113 QYQSILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIA 172
LEK T++ + K EDE+++ +++ N ++ L +E+++ +A
Sbjct: 978 -----LEKVTAEAKI-----KKLEDEILVMDDQ----NNKLSKERKLLEERISDLTTNLA 1023
Query: 173 SLE---RSLNLYRDKYQSSLSNIEL-----------LECQVKMLQGELGGIMGQEPENKG 218
E ++L ++K++S +S +E+ LE + L+G+ Q + +
Sbjct: 1024 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 219 DHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQD--------------DLIQELRNKLA 264
+++++ + ++ +E Q L+ + +++Q++ DL ++L ++ A
Sbjct: 1084 QIAELKMQ----LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1139
Query: 265 CSNALVLEREKALIKLQA------DFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQ 318
N ++ +L+A D TAT + + E+ ++ + K L E+ S
Sbjct: 1140 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ--EVTVLKKALDEETRSH 1197
Query: 319 CLHVEE----YQNLVKDLRVELEAVSEQKRNIMKDMMKLE---LDLHG---LREETSAHI 368
V+E + V++L +LE K N+ K+ LE DL G + + +
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257
Query: 369 ERKDKDITILQCRLQELQ------------------------------LEFTETQKLTLK 398
E K K L+ ++QELQ L E + + L
Sbjct: 1258 EHKKKK---LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314
Query: 399 KD-----KFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKS 453
KD LQ+ E+LQE ++ V L + E+E Q E EM EAKQ+
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE-EM---EAKQNLE 1370
Query: 454 KEAECKALQAEVQKLK--------NSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQR 505
+ +Q K K +LEE K++ + + Q EE A A LE T+
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1430
Query: 506 KLQK---GLLLD----KQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVE----ELSL 554
+LQ+ L++D +Q +++ QR+ L E + R R E E
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490
Query: 555 ELSEALRKLENSDKEKRQLQKTVAEQDMKMNDML---DRIKHQHREQGSIKCKLEEDLQE 611
+ R LE + + K +L++T +M D++ D + E K LE ++E
Sbjct: 1491 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1550
Query: 612 ATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQC 671
LE+ ++L+ +++ + +E ++AL+ +F ++ L+ + EE+ L+ +L
Sbjct: 1551 MKTQLEELEDELQATEDAKLRLEVNMQALKGQF---ERDLQARDEQNEEKRRQLQRQLHE 1607
Query: 672 CSTQLESSLNKYNTSQQVIQDLN---KEIALQKES-----------LMSLQAQL------ 711
T+LE + + + L K++ LQ +S L LQAQ+
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667
Query: 712 --DKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQT 769
D +++ + ++ +L Q+DL A E + L + L +
Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1727
Query: 770 QEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQH 829
+ L++E E R+ +L EL + +G + V ++ E++S ++ +
Sbjct: 1728 LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTA 1787
Query: 830 QNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTN 889
Q + E Q +E + ++ ++ + K + + Q+
Sbjct: 1788 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA-----------QLEEQ 1836
Query: 890 LEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQEN---KKLKKEIEEK 946
+EQ A++++ A + L + ++ + + ++ E+ ++ N K+LK+++EE
Sbjct: 1837 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEA 1896
Query: 947 KMKAENTRLCTKALGPSRTESTQREKVCG 975
+ +++ + L E+T+ + G
Sbjct: 1897 EEESQRINANRRKLQRELDEATESNEAMG 1925
Score = 129 bits (325), Expect = 1e-29
Identities = 196/960 (20%), Positives = 411/960 (42%), Gaps = 109/960 (11%)
Query: 81 RQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLHH-HCKLKEDEV 139
R ++K L V +QE EE+Q L++ + +K ++L L H +L E++
Sbjct: 843 RLFTKVKPLLQVTRQE-----EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKN 897
Query: 140 ILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQV 199
+L +E++ E E A+E K LE L+ + + + L+ +
Sbjct: 898 LL-QEQLQAETELYAE----AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAER 952
Query: 200 KMLQGELGGIMGQEPENKGDHSKVRI--YTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQ 257
K + ++ + Q E + K+++ T+ I++ ++ + + K+S++ L++
Sbjct: 953 KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1012
Query: 258 ELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDS 317
E + L + A E+ K L KL+ S I ++ L++++ S
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKLKNKHESM----------------ISELEVRLKKEEKS 1056
Query: 318 QCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITI 377
+ +E + L + L + EQ ++ + +L++ L EE A + R D +I
Sbjct: 1057 R----QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA- 1111
Query: 378 LQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKEL-EKQQC 436
+ LKK + L+ LQE +N K++++L E+ +
Sbjct: 1112 --------------QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157
Query: 437 MATELEMTVKE--------AKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQ 488
+ TELE T+ AK+++ KAL E + + ++E +Q+ A ++ +
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1217
Query: 489 CKEEAALAGCHLEDTQRKLQKG----------LLLDKQKAD-TIQELQRELQMLQKESSM 537
E+ A +L+ ++ L+K L KQ+ + ++L+ ++Q LQ + S
Sbjct: 1218 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277
Query: 538 AEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHRE 597
E+ + +V +L E+ L ++ + +L K VA ++ D + ++ + R+
Sbjct: 1278 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1337
Query: 598 QGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRK 657
+ ++ KL + L+E L+D+ ++ ++K++ + L + KKK +
Sbjct: 1338 KLNVSTKLRQ-LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1396
Query: 658 LEEENENLRAELQCCSTQLESSLNKY-------NTSQQVIQDLNKEIALQKESLMSL--- 707
LEE + + E++ + Q E Y N QQ + DL ++ Q++ + +L
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Query: 708 QAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLT 767
Q + D+ L +EK+ I+ + D R A ++ T+AL L E ++ L
Sbjct: 1457 QRKFDQLLAEEKN-----ISSKYADERDRAEAEAREKETKALS-LARALEEALEAKEELE 1510
Query: 768 QTQEK-KAQLEEEIIA----------YEERMKKLNTELRKLRGFHQESELEVHAFDKKLE 816
+T + KA++E+ + + E+ + L T++ +++ +E E E+ A +
Sbjct: 1511 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1570
Query: 817 EMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPK-- 874
+ + + Q + DL+ + E+ R + E LED+++ L + K
Sbjct: 1571 RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1630
Query: 875 -DTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQ 933
D L D + E+ KQ + KL Q+++ + + +D + +
Sbjct: 1631 GDLKDLELQADSAIKGREEAIKQLR----KLQAQMKDFQRELEDARASRDEIFAT----A 1682
Query: 934 QENKKLKKEIEEKKMK-AENTRLCTKALGPSRTESTQ-REKVCGTLGWKGLPQDMGQRMD 991
+EN+K K +E M+ E+ +A + E + E++ +L + QD +R++
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742
Score = 114 bits (284), Expect = 6e-25
Identities = 172/827 (20%), Positives = 340/827 (41%), Gaps = 113/827 (13%)
Query: 1 MKDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQA 60
+ +E + +V + K ++ + KR + L N+ +E+ ++ +
Sbjct: 1190 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK--ENADLAGEL 1247
Query: 61 QALAFEESEVEFGSSK-QCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYS----LRQYQ 115
+ L + EVE K + +++LQ + EL +LQ S L + +
Sbjct: 1248 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1307
Query: 116 SILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTG-----EKLHLAQEQLALAGDK 170
K D+ L +L++ + +L EE N +T E+ + Q+QL +
Sbjct: 1308 GKAIKLAKDVASLSS--QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365
Query: 171 IASLER---SLNLY----RDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKV 223
+LER +LN+ + K Q S +E LE K Q E+ + Q E + K+
Sbjct: 1366 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1425
Query: 224 RIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREK--ALIKLQ 281
++T+ RL + + DDL+ +L N+ + L ++ K L+ +
Sbjct: 1426 ------------EKTKNRLQQ------ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1467
Query: 282 ADFASCTATHRYPPSSSEECEDIK--KILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAV 339
+ +S A R + ++ K + + L+E +++ EE + K L+ E+E +
Sbjct: 1468 KNISSKYADERDRAEAEAREKETKALSLARALEEALEAK----EELERTNKMLKAEMEDL 1523
Query: 340 SEQKRNIMKDMMKLELDLHGLR---EETSAHIERKDKDITILQCRLQELQLEFTETQKLT 396
K ++ K++ +LE L EE +E + ++ + L++ Q L
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM---QALK 1580
Query: 397 LKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELE---KQQCMATELEMTVKEAKQDKS 453
+ ++ LQ +DE + E+K Q+Q L + E ELE KQ+ +A A K
Sbjct: 1581 GQFERDLQARDE---QNEEKRRQLQRQLHEYETELEDERKQRALA---------AAAKKK 1628
Query: 454 KEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLL 513
E + K L+ + EEA +Q R Q + E LED + +
Sbjct: 1629 LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE-------LEDARASRDEIFAT 1681
Query: 514 DKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQL 573
K+ + L+ +L LQ++ + AE+ + EEL+ EL+ +L EKR+L
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741
Query: 574 QKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLM 633
+ +A+ LEE+L+E +E ++++K+ + + +
Sbjct: 1742 EARIAQ-------------------------LEEELEEEQGNMEAMSDRVRKATQQAEQL 1776
Query: 634 EGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQ----CCSTQLESSLNKYNTSQQV 689
EL R +K + ++LE +N+ LR++L ++ +S++
Sbjct: 1777 SNELATERSTAQKNESA----RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1832
Query: 690 IQDLNKEIALQKESLMSLQAQLDK-----ALQKEKHYLQTTITKEAYDALSRKSAACQDD 744
+++ ++ A +K++ Q DK LQ E KE + + + +
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1892
Query: 745 LTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLN 791
L +A E+ + + + LQ+ L + E + E+ A + ++++ N
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1939
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 137 bits (345), Expect = 5e-32
Identities = 219/1109 (19%), Positives = 452/1109 (40%), Gaps = 176/1109 (15%)
Query: 2 KDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKR--QRKTLQDNQLCMEEAMNSSHDKKQ 59
++E ++ E+ + + ++K L + + K L QL E + + ++ +
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917
Query: 60 AQALAFEESEVEFGSSKQCHL-------RQLQQLKKKLLVLQQELEFHTEELQTSYYSLR 112
+ A ++ E + L +QLQ +KK+ +LE EE + + L+
Sbjct: 918 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 977
Query: 113 QYQSILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIA 172
LEK T++ + K EDE+++ +++ N ++ L +E+++ +A
Sbjct: 978 -----LEKVTAEAKI-----KKLEDEILVMDDQ----NNKLSKERKLLEERISDLTTNLA 1023
Query: 173 SLE---RSLNLYRDKYQSSLSNIEL-----------LECQVKMLQGELGGIMGQEPENKG 218
E ++L ++K++S +S +E+ LE + L+G+ Q + +
Sbjct: 1024 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 219 DHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQD--------------DLIQELRNKLA 264
+++++ + ++ +E Q L+ + +++Q++ DL ++L ++ A
Sbjct: 1084 QIAELKMQ----LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1139
Query: 265 CSNALVLEREKALIKLQA------DFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQ 318
N ++ +L+A D TAT + + E+ ++ + K L E+ S
Sbjct: 1140 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ--EVTVLKKALDEETRSH 1197
Query: 319 CLHVEE----YQNLVKDLRVELEAVSEQKRNIMKDMMKLE---LDLHG---LREETSAHI 368
V+E + V++L +LE K N+ K+ LE DL G + + +
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257
Query: 369 ERKDKDITILQCRLQELQ------------------------------LEFTETQKLTLK 398
E K K L+ ++QELQ L E + + L
Sbjct: 1258 EHKKKK---LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314
Query: 399 KD-----KFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKS 453
KD LQ+ E+LQE ++ V L + E+E Q E EM EAKQ+
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE-EM---EAKQNLE 1370
Query: 454 KEAECKALQAEVQKLK--------NSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQR 505
+ +Q K K +LEE K++ + + Q EE A A LE T+
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1430
Query: 506 KLQK---GLLLD----KQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVE----ELSL 554
+LQ+ L++D +Q +++ QR+ L E + R R E E
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490
Query: 555 ELSEALRKLENSDKEKRQLQKTVAEQDMKMNDML---DRIKHQHREQGSIKCKLEEDLQE 611
+ R LE + + K +L++T +M D++ D + E K LE ++E
Sbjct: 1491 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1550
Query: 612 ATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQC 671
LE+ ++L+ +++ + +E ++AL+ +F ++ L+ + EE+ L+ +L
Sbjct: 1551 MKTQLEELEDELQATEDAKLRLEVNMQALKGQF---ERDLQARDEQNEEKRRQLQRQLHE 1607
Query: 672 CSTQLESSLNKYNTSQQVIQDLN---KEIALQKES-----------LMSLQAQL------ 711
T+LE + + + L K++ LQ +S L LQAQ+
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667
Query: 712 --DKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQT 769
D +++ + ++ +L Q+DL A E + L + L +
Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1727
Query: 770 QEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQH 829
+ L++E E R+ +L EL + +G + V ++ E++S ++ +
Sbjct: 1728 LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTA 1787
Query: 830 QNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTN 889
Q + E Q +E + ++ ++ + K + + Q+
Sbjct: 1788 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA-----------QLEEQ 1836
Query: 890 LEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQEN---KKLKKEIEEK 946
+EQ A++++ A + L + ++ + + ++ E+ ++ N K+LK+++EE
Sbjct: 1837 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEA 1896
Query: 947 KMKAENTRLCTKALGPSRTESTQREKVCG 975
+ +++ + L E+T+ + G
Sbjct: 1897 EEESQRINANRRKLQRELDEATESNEAMG 1925
Score = 129 bits (325), Expect = 1e-29
Identities = 196/960 (20%), Positives = 411/960 (42%), Gaps = 109/960 (11%)
Query: 81 RQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLHH-HCKLKEDEV 139
R ++K L V +QE EE+Q L++ + +K ++L L H +L E++
Sbjct: 843 RLFTKVKPLLQVTRQE-----EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKN 897
Query: 140 ILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQV 199
+L +E++ E E A+E K LE L+ + + + L+ +
Sbjct: 898 LL-QEQLQAETELYAE----AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAER 952
Query: 200 KMLQGELGGIMGQEPENKGDHSKVRI--YTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQ 257
K + ++ + Q E + K+++ T+ I++ ++ + + K+S++ L++
Sbjct: 953 KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1012
Query: 258 ELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDS 317
E + L + A E+ K L KL+ S I ++ L++++ S
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKLKNKHESM----------------ISELEVRLKKEEKS 1056
Query: 318 QCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITI 377
+ +E + L + L + EQ ++ + +L++ L EE A + R D +I
Sbjct: 1057 R----QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA- 1111
Query: 378 LQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKEL-EKQQC 436
+ LKK + L+ LQE +N K++++L E+ +
Sbjct: 1112 --------------QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157
Query: 437 MATELEMTVKE--------AKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQ 488
+ TELE T+ AK+++ KAL E + + ++E +Q+ A ++ +
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1217
Query: 489 CKEEAALAGCHLEDTQRKLQKG----------LLLDKQKAD-TIQELQRELQMLQKESSM 537
E+ A +L+ ++ L+K L KQ+ + ++L+ ++Q LQ + S
Sbjct: 1218 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277
Query: 538 AEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHRE 597
E+ + +V +L E+ L ++ + +L K VA ++ D + ++ + R+
Sbjct: 1278 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1337
Query: 598 QGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRK 657
+ ++ KL + L+E L+D+ ++ ++K++ + L + KKK +
Sbjct: 1338 KLNVSTKLRQ-LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1396
Query: 658 LEEENENLRAELQCCSTQLESSLNKY-------NTSQQVIQDLNKEIALQKESLMSL--- 707
LEE + + E++ + Q E Y N QQ + DL ++ Q++ + +L
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Query: 708 QAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLT 767
Q + D+ L +EK+ I+ + D R A ++ T+AL L E ++ L
Sbjct: 1457 QRKFDQLLAEEKN-----ISSKYADERDRAEAEAREKETKALS-LARALEEALEAKEELE 1510
Query: 768 QTQEK-KAQLEEEIIA----------YEERMKKLNTELRKLRGFHQESELEVHAFDKKLE 816
+T + KA++E+ + + E+ + L T++ +++ +E E E+ A +
Sbjct: 1511 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1570
Query: 817 EMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPK-- 874
+ + + Q + DL+ + E+ R + E LED+++ L + K
Sbjct: 1571 RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1630
Query: 875 -DTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQ 933
D L D + E+ KQ + KL Q+++ + + +D + +
Sbjct: 1631 GDLKDLELQADSAIKGREEAIKQLR----KLQAQMKDFQRELEDARASRDEIFAT----A 1682
Query: 934 QENKKLKKEIEEKKMK-AENTRLCTKALGPSRTESTQ-REKVCGTLGWKGLPQDMGQRMD 991
+EN+K K +E M+ E+ +A + E + E++ +L + QD +R++
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742
Score = 112 bits (280), Expect = 2e-24
Identities = 171/824 (20%), Positives = 338/824 (41%), Gaps = 113/824 (13%)
Query: 1 MKDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQA 60
+ +E + +V + K ++ + KR + L N+ +E+ ++ +
Sbjct: 1190 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK--ENADLAGEL 1247
Query: 61 QALAFEESEVEFGSSK-QCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYS----LRQYQ 115
+ L + EVE K + +++LQ + EL +LQ S L + +
Sbjct: 1248 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1307
Query: 116 SILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTG-----EKLHLAQEQLALAGDK 170
K D+ L +L++ + +L EE N +T E+ + Q+QL +
Sbjct: 1308 GKAIKLAKDVASLSS--QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365
Query: 171 IASLER---SLNLY----RDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKV 223
+LER +LN+ + K Q S +E LE K Q E+ + Q E + K+
Sbjct: 1366 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1425
Query: 224 RIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREK--ALIKLQ 281
++T+ RL + + DDL+ +L N+ + L ++ K L+ +
Sbjct: 1426 ------------EKTKNRLQQ------ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1467
Query: 282 ADFASCTATHRYPPSSSEECEDIK--KILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAV 339
+ +S A R + ++ K + + L+E +++ EE + K L+ E+E +
Sbjct: 1468 KNISSKYADERDRAEAEAREKETKALSLARALEEALEAK----EELERTNKMLKAEMEDL 1523
Query: 340 SEQKRNIMKDMMKLELDLHGLR---EETSAHIERKDKDITILQCRLQELQLEFTETQKLT 396
K ++ K++ +LE L EE +E + ++ + L++ Q L
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM---QALK 1580
Query: 397 LKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELE---KQQCMATELEMTVKEAKQDKS 453
+ ++ LQ +DE + E+K Q+Q L + E ELE KQ+ +A A K
Sbjct: 1581 GQFERDLQARDE---QNEEKRRQLQRQLHEYETELEDERKQRALA---------AAAKKK 1628
Query: 454 KEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLL 513
E + K L+ + EEA +Q R Q + E LED + +
Sbjct: 1629 LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE-------LEDARASRDEIFAT 1681
Query: 514 DKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQL 573
K+ + L+ +L LQ++ + AE+ + EEL+ EL+ +L EKR+L
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741
Query: 574 QKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLM 633
+ +A+ LEE+L+E +E ++++K+ + + +
Sbjct: 1742 EARIAQ-------------------------LEEELEEEQGNMEAMSDRVRKATQQAEQL 1776
Query: 634 EGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQ----CCSTQLESSLNKYNTSQQV 689
EL R +K + ++LE +N+ LR++L ++ +S++
Sbjct: 1777 SNELATERSTAQKNESA----RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1832
Query: 690 IQDLNKEIALQKESLMSLQAQLDK-----ALQKEKHYLQTTITKEAYDALSRKSAACQDD 744
+++ ++ A +K++ Q DK LQ E KE + + + +
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1892
Query: 745 LTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMK 788
L +A E+ + + + LQ+ L + E + E+ A + +++
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 137 bits (345), Expect = 5e-32
Identities = 219/1109 (19%), Positives = 452/1109 (40%), Gaps = 176/1109 (15%)
Query: 2 KDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKR--QRKTLQDNQLCMEEAMNSSHDKKQ 59
++E ++ E+ + + ++K L + + K L QL E + + ++ +
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910
Query: 60 AQALAFEESEVEFGSSKQCHL-------RQLQQLKKKLLVLQQELEFHTEELQTSYYSLR 112
+ A ++ E + L +QLQ +KK+ +LE EE + + L+
Sbjct: 911 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 970
Query: 113 QYQSILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIA 172
LEK T++ + K EDE+++ +++ N ++ L +E+++ +A
Sbjct: 971 -----LEKVTAEAKI-----KKLEDEILVMDDQ----NNKLSKERKLLEERISDLTTNLA 1016
Query: 173 SLE---RSLNLYRDKYQSSLSNIEL-----------LECQVKMLQGELGGIMGQEPENKG 218
E ++L ++K++S +S +E+ LE + L+G+ Q + +
Sbjct: 1017 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 219 DHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQD--------------DLIQELRNKLA 264
+++++ + ++ +E Q L+ + +++Q++ DL ++L ++ A
Sbjct: 1077 QIAELKMQ----LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1132
Query: 265 CSNALVLEREKALIKLQA------DFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQ 318
N ++ +L+A D TAT + + E+ ++ + K L E+ S
Sbjct: 1133 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ--EVTVLKKALDEETRSH 1190
Query: 319 CLHVEE----YQNLVKDLRVELEAVSEQKRNIMKDMMKLE---LDLHG---LREETSAHI 368
V+E + V++L +LE K N+ K+ LE DL G + + +
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250
Query: 369 ERKDKDITILQCRLQELQ------------------------------LEFTETQKLTLK 398
E K K L+ ++QELQ L E + + L
Sbjct: 1251 EHKKKK---LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307
Query: 399 KD-----KFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKS 453
KD LQ+ E+LQE ++ V L + E+E Q E EM EAKQ+
Sbjct: 1308 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE-EM---EAKQNLE 1363
Query: 454 KEAECKALQAEVQKLK--------NSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQR 505
+ +Q K K +LEE K++ + + Q EE A A LE T+
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1423
Query: 506 KLQK---GLLLD----KQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVE----ELSL 554
+LQ+ L++D +Q +++ QR+ L E + R R E E
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1483
Query: 555 ELSEALRKLENSDKEKRQLQKTVAEQDMKMNDML---DRIKHQHREQGSIKCKLEEDLQE 611
+ R LE + + K +L++T +M D++ D + E K LE ++E
Sbjct: 1484 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1543
Query: 612 ATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQC 671
LE+ ++L+ +++ + +E ++AL+ +F ++ L+ + EE+ L+ +L
Sbjct: 1544 MKTQLEELEDELQATEDAKLRLEVNMQALKGQF---ERDLQARDEQNEEKRRQLQRQLHE 1600
Query: 672 CSTQLESSLNKYNTSQQVIQDLN---KEIALQKES-----------LMSLQAQL------ 711
T+LE + + + L K++ LQ +S L LQAQ+
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660
Query: 712 --DKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQT 769
D +++ + ++ +L Q+DL A E + L + L +
Sbjct: 1661 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1720
Query: 770 QEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQH 829
+ L++E E R+ +L EL + +G + V ++ E++S ++ +
Sbjct: 1721 LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTA 1780
Query: 830 QNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTN 889
Q + E Q +E + ++ ++ + K + + Q+
Sbjct: 1781 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA-----------QLEEQ 1829
Query: 890 LEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQEN---KKLKKEIEEK 946
+EQ A++++ A + L + ++ + + ++ E+ ++ N K+LK+++EE
Sbjct: 1830 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEA 1889
Query: 947 KMKAENTRLCTKALGPSRTESTQREKVCG 975
+ +++ + L E+T+ + G
Sbjct: 1890 EEESQRINANRRKLQRELDEATESNEAMG 1918
Score = 129 bits (325), Expect = 1e-29
Identities = 196/960 (20%), Positives = 411/960 (42%), Gaps = 109/960 (11%)
Query: 81 RQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLHH-HCKLKEDEV 139
R ++K L V +QE EE+Q L++ + +K ++L L H +L E++
Sbjct: 836 RLFTKVKPLLQVTRQE-----EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKN 890
Query: 140 ILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQV 199
+L +E++ E E A+E K LE L+ + + + L+ +
Sbjct: 891 LL-QEQLQAETELYAE----AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAER 945
Query: 200 KMLQGELGGIMGQEPENKGDHSKVRI--YTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQ 257
K + ++ + Q E + K+++ T+ I++ ++ + + K+S++ L++
Sbjct: 946 KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1005
Query: 258 ELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDS 317
E + L + A E+ K L KL+ S I ++ L++++ S
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESM----------------ISELEVRLKKEEKS 1049
Query: 318 QCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITI 377
+ +E + L + L + EQ ++ + +L++ L EE A + R D +I
Sbjct: 1050 R----QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA- 1104
Query: 378 LQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKEL-EKQQC 436
+ LKK + L+ LQE +N K++++L E+ +
Sbjct: 1105 --------------QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150
Query: 437 MATELEMTVKE--------AKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQ 488
+ TELE T+ AK+++ KAL E + + ++E +Q+ A ++ +
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1210
Query: 489 CKEEAALAGCHLEDTQRKLQKG----------LLLDKQKAD-TIQELQRELQMLQKESSM 537
E+ A +L+ ++ L+K L KQ+ + ++L+ ++Q LQ + S
Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270
Query: 538 AEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHRE 597
E+ + +V +L E+ L ++ + +L K VA ++ D + ++ + R+
Sbjct: 1271 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1330
Query: 598 QGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRK 657
+ ++ KL + L+E L+D+ ++ ++K++ + L + KKK +
Sbjct: 1331 KLNVSTKLRQ-LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1389
Query: 658 LEEENENLRAELQCCSTQLESSLNKY-------NTSQQVIQDLNKEIALQKESLMSL--- 707
LEE + + E++ + Q E Y N QQ + DL ++ Q++ + +L
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Query: 708 QAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLT 767
Q + D+ L +EK+ I+ + D R A ++ T+AL L E ++ L
Sbjct: 1450 QRKFDQLLAEEKN-----ISSKYADERDRAEAEAREKETKALS-LARALEEALEAKEELE 1503
Query: 768 QTQEK-KAQLEEEIIA----------YEERMKKLNTELRKLRGFHQESELEVHAFDKKLE 816
+T + KA++E+ + + E+ + L T++ +++ +E E E+ A +
Sbjct: 1504 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1563
Query: 817 EMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPK-- 874
+ + + Q + DL+ + E+ R + E LED+++ L + K
Sbjct: 1564 RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1623
Query: 875 -DTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQ 933
D L D + E+ KQ + KL Q+++ + + +D + +
Sbjct: 1624 GDLKDLELQADSAIKGREEAIKQLR----KLQAQMKDFQRELEDARASRDEIFAT----A 1675
Query: 934 QENKKLKKEIEEKKMK-AENTRLCTKALGPSRTESTQ-REKVCGTLGWKGLPQDMGQRMD 991
+EN+K K +E M+ E+ +A + E + E++ +L + QD +R++
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735
Score = 112 bits (280), Expect = 2e-24
Identities = 171/824 (20%), Positives = 338/824 (41%), Gaps = 113/824 (13%)
Query: 1 MKDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQA 60
+ +E + +V + K ++ + KR + L N+ +E+ ++ +
Sbjct: 1183 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK--ENADLAGEL 1240
Query: 61 QALAFEESEVEFGSSK-QCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYS----LRQYQ 115
+ L + EVE K + +++LQ + EL +LQ S L + +
Sbjct: 1241 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1300
Query: 116 SILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTG-----EKLHLAQEQLALAGDK 170
K D+ L +L++ + +L EE N +T E+ + Q+QL +
Sbjct: 1301 GKAIKLAKDVASLSS--QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1358
Query: 171 IASLER---SLNLY----RDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKV 223
+LER +LN+ + K Q S +E LE K Q E+ + Q E + K+
Sbjct: 1359 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1418
Query: 224 RIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREK--ALIKLQ 281
++T+ RL + + DDL+ +L N+ + L ++ K L+ +
Sbjct: 1419 ------------EKTKNRLQQ------ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1460
Query: 282 ADFASCTATHRYPPSSSEECEDIK--KILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAV 339
+ +S A R + ++ K + + L+E +++ EE + K L+ E+E +
Sbjct: 1461 KNISSKYADERDRAEAEAREKETKALSLARALEEALEAK----EELERTNKMLKAEMEDL 1516
Query: 340 SEQKRNIMKDMMKLELDLHGLR---EETSAHIERKDKDITILQCRLQELQLEFTETQKLT 396
K ++ K++ +LE L EE +E + ++ + L++ Q L
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM---QALK 1573
Query: 397 LKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELE---KQQCMATELEMTVKEAKQDKS 453
+ ++ LQ +DE + E+K Q+Q L + E ELE KQ+ +A A K
Sbjct: 1574 GQFERDLQARDE---QNEEKRRQLQRQLHEYETELEDERKQRALA---------AAAKKK 1621
Query: 454 KEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLL 513
E + K L+ + EEA +Q R Q + E LED + +
Sbjct: 1622 LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE-------LEDARASRDEIFAT 1674
Query: 514 DKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQL 573
K+ + L+ +L LQ++ + AE+ + EEL+ EL+ +L EKR+L
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734
Query: 574 QKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLM 633
+ +A+ LEE+L+E +E ++++K+ + + +
Sbjct: 1735 EARIAQ-------------------------LEEELEEEQGNMEAMSDRVRKATQQAEQL 1769
Query: 634 EGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQ----CCSTQLESSLNKYNTSQQV 689
EL R +K + ++LE +N+ LR++L ++ +S++
Sbjct: 1770 SNELATERSTAQKNESA----RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1825
Query: 690 IQDLNKEIALQKESLMSLQAQLDK-----ALQKEKHYLQTTITKEAYDALSRKSAACQDD 744
+++ ++ A +K++ Q DK LQ E KE + + + +
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1885
Query: 745 LTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMK 788
L +A E+ + + + LQ+ L + E + E+ A + +++
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 137 bits (344), Expect = 7e-32
Identities = 218/1004 (21%), Positives = 439/1004 (43%), Gaps = 137/1004 (13%)
Query: 1 MKDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDK--- 57
++ E + +V +L ++ L I L +++K LQ+ + + + DK
Sbjct: 967 VEKEKHATENKVKNLTEEMAGLDETIAKL----SKEKKALQETHQQTLDDLQAEEDKVNI 1022
Query: 58 --KQAQALAFEESEVEFGSSKQCHLRQ-LQQLKKKLLVLQQELEFHTEELQTSYYSLRQY 114
K L + ++E ++ LR L++ K+KL + +L+ E +Q
Sbjct: 1023 LTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKL---EGDLKLAQESTMDMENDKQQL 1079
Query: 115 QSILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASL 174
LEK+ ++ L K+++++ + + + +K+ Q ++ G++I +
Sbjct: 1080 DEKLEKKEFEISNLIS--KIEDEQAVEIQLQ---------KKIKELQARIEELGEEIEA- 1127
Query: 175 ERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPE----NKGDHSKVRIYTSPC 230
ER+ +K +S LS EL E ++ E GG + E + + K+R
Sbjct: 1128 ERASRAKAEKQRSDLSR-ELEEISERL--EEAGGATSAQVELNKKREAEFQKLRRDLEEA 1184
Query: 231 MIQEHQET---QKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASC 287
+Q +K+ ++ ++ +Q D +Q ++ KL E+EK+ +K++ D S
Sbjct: 1185 TLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKL--------EKEKSELKMETDDLSS 1236
Query: 288 TATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDL-----RVELEA---- 338
A + S+ +++K+ + L++Q EE Q L+ DL R++ EA
Sbjct: 1237 NAE-----AISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYS 1291
Query: 339 ---------VSEQKRNIMKDMMKLELDLHGLREETSAH------IERKDKDITILQCRLQ 383
VS+ R+ ++E H L EET A ++ D +L+ + +
Sbjct: 1292 RQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYE 1351
Query: 384 ELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEM 443
E Q E Q+ K + E+ + T+ + +++ +ELE+ + +L
Sbjct: 1352 EEQEGKAELQRALSKANS----------EVAQWRTKYETDAIQRTEELEEAK---KKLAQ 1398
Query: 444 TVKEAKQD-KSKEAECKALQAEVQKLKNSLEEAKQQ-ERLAAQQAAQCKEEAALAGCHLE 501
++EA++ ++ A+C +L+ Q+L+N +E+ ER A AA L+
Sbjct: 1399 RLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAA------------LD 1446
Query: 502 DTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALR 561
QR K L KQK +E Q EL+ QKES E + EE +L R
Sbjct: 1447 KKQRNFDKVLSEWKQK---YEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRR 1503
Query: 562 KLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKRE 621
+ +N +E L + +AE ++++ L++IK Q ++ KC+++ L+EA LE
Sbjct: 1504 ENKNLQQEISDLTEQIAEGGKQIHE-LEKIKKQVEQE---KCEIQAALEEAEASLEH--- 1556
Query: 622 QLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLN 681
E K++ +LE L Q + D+ + E ++++ N ++ + L++ +
Sbjct: 1557 ------EEGKILRIQLE-LNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIR 1609
Query: 682 KYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTT-ITKEAYDALSRKSAA 740
N + +V + + ++ E + L A + ++Y T I KE L +
Sbjct: 1610 SRNDALRVKKKMEGDL---NEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLD-DALR 1665
Query: 741 CQDDLTQAL----EKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRK 796
Q+DL + L + N + +E + L +L QT+ + E+E++ ER++ L+T+
Sbjct: 1666 GQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1725
Query: 797 LRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAAL--- 853
L ++ E +V ++EE+ + +++ + + A E+L++ Q+ A L
Sbjct: 1726 LINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1785
Query: 854 KENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQI------MTNLEQWAKQQKVANEKLGNQ 907
K+NL + K+ L + L G QI + LE + ++ N +
Sbjct: 1786 KKNLEQTVKD---LQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKG 1842
Query: 908 LREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAE 951
LR+ + + +L+ + + ++ LQ KL+ +++ K +AE
Sbjct: 1843 LRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAE 1886
Score = 121 bits (303), Expect = 4e-27
Identities = 172/828 (20%), Positives = 351/828 (42%), Gaps = 117/828 (14%)
Query: 170 KIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQ------EPENKGDHSKV 223
K A E+ + ++++Q + + E + K L+ ++ ++ + + +++ D
Sbjct: 844 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLAD 903
Query: 224 RIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQAD 283
+I+ + + ++ EV ++ +++++ EL K E +K + L+
Sbjct: 904 AEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELT 963
Query: 284 FASCT----ATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAV 339
A AT + +EE + + + L ++K + E +Q + DL+ E
Sbjct: 964 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKAL---QETHQQTLDDLQAE---- 1016
Query: 340 SEQKRNIM-KDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLK 398
E K NI+ K KLE + ++ +E++ K L+ ++L+ + Q+ T+
Sbjct: 1017 -EDKVNILTKAKTKLEQQV----DDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMD 1071
Query: 399 KDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAEC 458
+ Q+ DE +LEKK ++ N + K +E +Q + +L+ +KE
Sbjct: 1072 MENDKQQLDE---KLEKKEFEISNLISK----IEDEQAVEIQLQKKIKE----------- 1113
Query: 459 KALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKA 518
LQA +++L +E + A +Q + E LE+ + L+K++
Sbjct: 1114 --LQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKRE 1171
Query: 519 DTIQELQRELQ--MLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKT 576
Q+L+R+L+ LQ E+ +A + RK+ + EL E +++N + K++L+K
Sbjct: 1172 AEFQKLRRDLEEATLQHEAMVA-----ALRKKHADSMAELGE---QIDNLQRVKQKLEKE 1223
Query: 577 VAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGE 636
+E M+ +D+ + + +G+ L++ + LED+ +LK +E ++ + +
Sbjct: 1224 KSELKMETDDLSSNAEAISKAKGN--------LEKMCRSLEDQVSELKTKEEEQQRLIND 1275
Query: 637 LEALR-----------QEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNT 685
L A R ++ +KD + + SR + + + EL+ QLE N
Sbjct: 1276 LTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIE-ELK---HQLEEETKAKNA 1331
Query: 686 SQQVIQDLNKEIALQKESLMSLQ---AQLDKALQKEKHYLQTTITKEAYDALSRKSAACQ 742
+Q + L +E Q A+L +AL K + TK DA+ R
Sbjct: 1332 LAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQR------ 1385
Query: 743 DDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQ 802
T+ LE+ K L Q L + +E + + + E+ ++L E+ L +
Sbjct: 1386 ---TEELEEAK------KKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVE 1436
Query: 803 ESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALK-------- 854
S A DKK + +W+++++ L A +++ R E+ +K
Sbjct: 1437 RSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLD 1496
Query: 855 --ENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQV 912
E L ++K Q + T ++ G QI LE+ KQ + ++ L E
Sbjct: 1497 QLETLRRENKN----LQQEISDLTEQIAEGGKQI-HELEKIKKQVEQEKCEIQAALEEAE 1551
Query: 913 KYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEK-----KMKAENTRL 955
A L E+ + + + L Q ++ ++I EK ++K +TR+
Sbjct: 1552 ---ASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRV 1596
Score = 105 bits (262), Expect = 2e-22
Identities = 175/855 (20%), Positives = 359/855 (41%), Gaps = 112/855 (13%)
Query: 3 DEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQA 62
+E ER E S + L K ++ R+ L++ L EAM ++ KK A +
Sbjct: 1147 EEISERLEEAGGATSAQVELN---KKREAEFQKLRRDLEEATL-QHEAMVAALRKKHADS 1202
Query: 63 LAFEESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQT 122
+A E G + LQ++K+KL + EL+ T++L ++ ++ + + LEK
Sbjct: 1203 MA------ELGEQ----IDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMC 1252
Query: 123 SDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERS----L 178
L K KE EE+ N+ T ++ L E AG+ L+
Sbjct: 1253 RSLEDQVSELKTKE------EEQQRLINDLTAQRARLQTE----AGEYSRQLDEKDALVS 1302
Query: 179 NLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQET 238
L R K Q+S IE L+ Q++ + ++ D +R ++++E
Sbjct: 1303 QLSRSK-QASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLR--------EQYEEE 1353
Query: 239 QKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFAS-CTATHRYPPSS 297
Q+ +E+ + +S+ + + + R K ++R + L + + A + +
Sbjct: 1354 QEGKAELQRALSKANSEVAQWRTKYETD---AIQRTEELEEAKKKLAQRLQEAEEHVEAV 1410
Query: 298 SEECEDIKKILKHLQEQKDSQCLHVE---------------------EYQNLVKDLRVEL 336
+ +C ++K + LQ + + L VE E++ ++ + EL
Sbjct: 1411 NAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAEL 1470
Query: 337 EAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQK-- 394
EA ++ R++ ++ K++ + EE+ +E ++ LQ + +L + E K
Sbjct: 1471 EASQKESRSLSTELFKVK----NVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQI 1526
Query: 395 --LTLKKDKFLQEKDEM---LQELEKKLTQVQNSLLKKEKELEKQQCMA----TELEMTV 445
L K + QEK E+ L+E E L + +L+ + EL + + E + +
Sbjct: 1527 HELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEI 1586
Query: 446 KEAKQDKSKEAEC--KALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDT 503
+ K++ ++ E L AE++ ++L K+ E + Q LA L +
Sbjct: 1587 DQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNY 1646
Query: 504 QRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKL 563
+ +G+L + Q + + R + L+++ ++ E+ R L E+ E L
Sbjct: 1647 RNT--QGILKETQLH--LDDALRGQEDLKEQLAIVER-------RANLLQAEIEELWATL 1695
Query: 564 ENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSI---KCKLEEDLQEATKLLEDKR 620
E +++ ++ +AEQ++ D +R++ H + S+ K KLE D+ + +E+
Sbjct: 1696 EQTERSRK-----IAEQELL--DASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVI 1748
Query: 621 EQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESS- 679
++ + ++E K + + +E KK+ T S LE +NL ++ +L+ +
Sbjct: 1749 QESRNAEEKAKKAITDAAMMAEELKKEQDT----SAHLERMKKNLEQTVKDLQHRLDEAE 1804
Query: 680 ---LNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSR 736
L Q ++ +E+ + E+ A+ K L+K + ++ + D R
Sbjct: 1805 QLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEED---R 1861
Query: 737 KSAACQDDLTQALE-KLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELR 795
K+ DL L+ K+ + + ++ K +L+ E+ EER +++
Sbjct: 1862 KNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVN 1921
Query: 796 KLRGFHQESELEVHA 810
KLR +E ++ A
Sbjct: 1922 KLRVKSREVHTKISA 1936
Score = 95.1 bits (235), Expect = 3e-19
Identities = 140/676 (20%), Positives = 292/676 (43%), Gaps = 104/676 (15%)
Query: 1 MKDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQA 60
+K + E + ++L L S + D D+ + Q + Q+ + ++ A++ ++ +
Sbjct: 1318 LKHQLEEETKAKNALAHALQSSRHDC----DLLREQYEEEQEGKAELQRALSKANSEVAQ 1373
Query: 61 QALAFEESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEK 120
+E ++ +L++ KKKL QE E H E + SL + + L+
Sbjct: 1374 WRTKYETDAIQ-------RTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQN 1426
Query: 121 QTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGE---KLHLAQEQLALAGDKIASLERS 177
+ DL+L + +++ N ++ E K Q +L + + SL
Sbjct: 1427 EVEDLML---DVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTE 1483
Query: 178 LNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPEN-KGDHS----KVRIYTSPCMI 232
L ++ Y+ SL +E L + K LQ E+ + Q E K H K ++ C I
Sbjct: 1484 LFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEI 1543
Query: 233 Q----------EHQETQ---------KRLSEVWQKVSQQDDLIQELRNKLACSNALVLER 273
Q EH+E + + SEV +K++++D+ I +L+ ++ V+E
Sbjct: 1544 QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKR----NHTRVVET 1599
Query: 274 EKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLR 333
++ L A+ S R + +++ L H + Q ++K+ +
Sbjct: 1600 MQST--LDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQ 1657
Query: 334 VELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQ 393
+ L+ D ++ + DL +E A +ER+ +LQ ++EL +T+
Sbjct: 1658 LHLD-----------DALRGQEDL----KEQLAIVERR---ANLLQAEIEELWATLEQTE 1699
Query: 394 KLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKS 453
+ ++ L + E +Q L + T SL+ +K+LE ++L+ V+E
Sbjct: 1700 RSRKIAEQELLDASERVQLLHTQNT----SLINTKKKLEND---VSQLQSEVEEV----- 1747
Query: 454 KEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLL 513
+Q+ +N+ E+AK+ AA A + K+E + HLE ++ L++ +
Sbjct: 1748 -----------IQESRNAEEKAKKAITDAAMMAEELKKEQDTSA-HLERMKKNLEQTVKD 1795
Query: 514 DKQKADTIQEL-----QRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDK 568
+ + D ++L ++++Q L+ E E + +KR + E + LRK E K
Sbjct: 1796 LQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKR----NAEAVKGLRKHERRVK 1851
Query: 569 EKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKRE---QLKK 625
E + + +++ D++D+++ + + S K + EE +++ L R+ +L++
Sbjct: 1852 ELTYQTEEDRKNVLRLQDLVDKLQAKVK---SYKRQAEEAEEQSNANLSKFRKLQHELEE 1908
Query: 626 SKEHEKLMEGELEALR 641
++E + E ++ LR
Sbjct: 1909 AEERADIAESQVNKLR 1924
Score = 71.2 bits (173), Expect = 4e-12
Identities = 94/482 (19%), Positives = 200/482 (41%), Gaps = 75/482 (15%)
Query: 505 RKLQKGLLLDKQKADTIQELQR---ELQMLQKESSMAEKEQTSNRKRVEELSLELSEALR 561
+ L K +K+ A +E Q+ EL + + E++ + K +L L++
Sbjct: 840 KPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEAD 899
Query: 562 KLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSI---KCKLEEDLQEATKLLED 618
L ++++ QL K + + K+ ++ +R + + + K KLE++ E K ++D
Sbjct: 900 SLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDD 959
Query: 619 KREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLES 678
L K ++ + E +++ L +E D+T+ KL +E + L+
Sbjct: 960 LELTLAKVEKEKHATENKVKNLTEEMAGLDETIA----KLSKEKKALQ------------ 1003
Query: 679 SLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKS 738
T QQ + DL E E +++ + L+++ L+ ++ +E
Sbjct: 1004 -----ETHQQTLDDLQAE-----EDKVNILTKAKTKLEQQVDDLEGSLEQEK-------- 1045
Query: 739 AACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLR 798
+ DL +A KL + K Q+S + K QL+E++ E + L +++
Sbjct: 1046 -KLRMDLERAKRKLE---GDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIE--- 1098
Query: 799 GFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLL 858
E +E+ KK++E+ ++ + ++ + + A E+Q + E+ + E L
Sbjct: 1099 ---DEQAVEIQ-LQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLE 1154
Query: 859 EDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKL 918
E Q+ N ++ A+ QK+ + L+ + A
Sbjct: 1155 EAGGATSA------------------QVELNKKREAEFQKLRRDLEEATLQHEAMVAALR 1196
Query: 919 SGEKDHLHSV---MVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRTESTQREKVCG 975
D + + + +LQ+ +KL+KE E KM+ ++ +A+ ++ EK+C
Sbjct: 1197 KKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAK---GNLEKMCR 1253
Query: 976 TL 977
+L
Sbjct: 1254 SL 1255
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 135 bits (341), Expect = 1e-31
Identities = 223/1052 (21%), Positives = 460/1052 (43%), Gaps = 168/1052 (15%)
Query: 7 ERDREVSSLNSKLLSLQL---DIKNLHDVCKRQRKTLQD---NQLCMEEAMNSSHDKKQA 60
E+ +++ ++ ++ +Q +I+NL + K + TL+ +L + + +N ++++ ++
Sbjct: 1138 EKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKS 1197
Query: 61 ---QALAFEESEVEFGSSKQCHLR-QLQQLKKKLLVLQQELEF---HTEELQTSYYSLRQ 113
+ +E + F + + HLR +++++ L ++EL+ H +E Q + LR+
Sbjct: 1198 ITKERKVLKELQKSFETERD-HLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRR 1256
Query: 114 YQSILEKQTSDLV----LLHHHCKLKEDEVILYEE--------EMGNHNENTGEKLHLAQ 161
S+ EK T+ ++ L H KL+E+ +L+EE E+ E E L +
Sbjct: 1257 --SVSEK-TAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTE 1313
Query: 162 EQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHS 221
+ +A +E +K+Q S I+ L + L+ + + E K D
Sbjct: 1314 QSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLK-----TIKEALEVKHDQL 1368
Query: 222 KVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQ 281
K I + IQE Q Q++ + +K ++ ++ E+ ++ AL++++
Sbjct: 1369 KEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQ--------FKPKDSALLRIE 1420
Query: 282 ADFASCTA----THRYPPSSSEECEDIKK-------------------ILKHLQEQKDSQ 318
+ + +H S ++E +D+++ + KHL+ +++ +
Sbjct: 1421 IEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELK 1480
Query: 319 CLH--VEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKD-KDI 375
H ++E + + +LRV L + I K + + L +E E+ + K I
Sbjct: 1481 VAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQI 1540
Query: 376 TILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSL--LKKEKELEK 433
+ +Q ++ EL+ +F E +K KD LQ + + EL +L + Q + + KEKE K
Sbjct: 1541 SEVQEKVNELK-QFKEHRKA---KDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMK 1596
Query: 434 Q-----QCMATELEMTVKE--AKQDKSKEAECKALQ-----------AEVQKLKNSLEEA 475
+ Q +L+ KE AK +S+E E + L+ E++ LK E
Sbjct: 1597 RVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQ 1656
Query: 476 K------QQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLL--DKQKADTIQELQRE 527
K + E + Q E + D R +++ L + D+ K + + + R+
Sbjct: 1657 KLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRD 1716
Query: 528 LQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDM 587
L+ Q+E + +++ +++L +SE ++ N K+ + QD+K+ +
Sbjct: 1717 LEK-QEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEE 1775
Query: 588 LDRIKHQH-REQGSIKCKL--------------EEDLQEATKLLEDKREQLKKSKEHEKL 632
L RI H H +EQ KL ++DL+ + L++K ++L K+ EH+ +
Sbjct: 1776 L-RIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQEL-KANEHQLI 1833
Query: 633 -----------MEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLN 681
E+E L+++ K + TL KLE EN NL +L +++S +
Sbjct: 1834 TLKKDVNETQKKVSEMEQLKKQIKDQSLTLS----KLEIENLNLAQKLHENLEEMKSVMK 1889
Query: 682 KYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAAC 741
+ + ++V + L E KESL +A+ D +Q+E L+T LS++
Sbjct: 1890 ERDNLRRVEETLKLERDQLKESLQETKAR-DLEIQQE---LKTA------RMLSKEHKET 1939
Query: 742 QDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFH 801
D L EK++ T + +Q+ L + K +L+++I + ++K +L +++
Sbjct: 1940 VDKLR---EKISEKTIQISDIQKDL---DKSKDELQKKI----QELQKKELQLLRVKEDV 1989
Query: 802 QESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREF------QEEMAALKE 855
S +++ ++ ++ Q L Q ++ ++ E L E ++E+ +KE
Sbjct: 1990 NMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKE 2049
Query: 856 NLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYI 915
+L + + + + +D R N Q+ + Q+ E L + ++K +
Sbjct: 2050 SLKMERDQFIATLREMIARD-----RQNHQVKPEKRLLSDGQQHLTESLREKC-SRIKEL 2103
Query: 916 AKLSGEKDHLHSVMVHLQQENKKLKKEIEEKK 947
K E D + + L + L+KEIE +K
Sbjct: 2104 LKRYSEMDDHYECLNRLSLD---LEKEIEFQK 2132
Score = 135 bits (339), Expect = 3e-31
Identities = 224/1028 (21%), Positives = 439/1028 (42%), Gaps = 162/1028 (15%)
Query: 1 MKDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQA 60
++ E + E +L +++ L ++K+L +R RK +QD E + +S K
Sbjct: 725 LQKELNKEVEENEALREEVILLS-ELKSLPSEVERLRKEIQDKS--EELHIITSEKDKLF 781
Query: 61 QALAFEESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQ---TSYYSLRQ-YQS 116
+ +ES V Q L ++ + K L Q + +E Q T + Q Y+
Sbjct: 782 SEVVHKESRV------QGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKM 835
Query: 117 ILE---KQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQE----------Q 163
+LE + ++V L + + + + E+ + EK QE Q
Sbjct: 836 VLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQ 895
Query: 164 LALAGDKIASLERSLNLYRDKYQSSLSNIELLECQ---VKMLQGELGGIMGQEPENKGDH 220
L + ++ER L +K Q +L ++ L + +K LQ L + + D
Sbjct: 896 LENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESL--------QIERDQ 947
Query: 221 SKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKL 280
K I+ + + + +TQ++L + + Q + I L++K++ + L E+ +
Sbjct: 948 LKSDIHDT---VNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGET 1004
Query: 281 QADF--------------ASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLH---VE 323
+ +F A T T +E E +KI +QE+ + Q + +
Sbjct: 1005 KDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIA 1064
Query: 324 EYQNLVKDLR--VELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCR 381
E + L DL+ +E+ ++++ ++ D +K + ++ + H +K+ +++ R
Sbjct: 1065 EKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKN---HAIKKEGELSRTCDR 1121
Query: 382 LQELQLEFTE-TQKLTLKKDKFLQEKDEMLQELEKKLTQVQN---SLLKKEKELEKQQCM 437
L E++ + E +Q+L K+ + L ++EM E++KK+ +++N L KE LE +
Sbjct: 1122 LAEVEEKLKEKSQQLQEKQQQLLNVQEEM-SEMQKKINEIENLKNELKNKELTLEHMETE 1180
Query: 438 ATELEMTVKEAKQD-KSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALA 496
EL + E ++ KS E K L+ + + + + R Q KEE +A
Sbjct: 1181 RLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIA 1240
Query: 497 GCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKE-QTSNRKRVEELSLE 555
HL++ Q +TI EL+R S++EK Q N + +E+ +
Sbjct: 1241 HIHLKEHQ--------------ETIDELRR---------SVSEKTAQIINTQDLEKSHTK 1277
Query: 556 LSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKL 615
L E + L + ++E K V+E MN++ + + + ++E + +
Sbjct: 1278 LQEEIPVL-HEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEK 1336
Query: 616 LEDKREQLKK-SKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCST 674
++ +E++K +KE + L + +++ + K LKE+ R+ A++Q +
Sbjct: 1337 FQESQEEIKSLTKERDNL-----KTIKEALEVKHDQLKEHIRET-------LAKIQESQS 1384
Query: 675 QLESSLN---KYNTSQQVIQDLNKEIALQKESLMSLQAQ---LDKALQKEKHYLQTTITK 728
+ E SLN K N + +++ ++ ++ + +L+ ++ + L K LQ E H ++ K
Sbjct: 1385 KQEQSLNMKEKDNETTKIVSEM-EQFKPKDSALLRIEIEMLGLSKRLQ-ESHDEMKSVAK 1442
Query: 729 EAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMK 788
E +DDL + E L SE+ L++++ + K + EEE+ +K
Sbjct: 1443 E------------KDDLQRLQEVLQ---SESDQLKENIKEIVAKHLETEEELKVAHCCLK 1487
Query: 789 KLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQE 848
+ + +LR E E E+ K+LE ++ ++ QN ++ + KEEQ Q
Sbjct: 1488 EQEETINELRVNLSEKETEISTIQKQLEAINDKL-------QNKIQEIYEKEEQFNIKQI 1540
Query: 849 EMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQL 908
K N L+ KE + D + ++E + L N+L
Sbjct: 1541 SEVQEKVNELKQFKEH---------------RKAKDSALQSIESKMLE-------LTNRL 1578
Query: 909 REQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEE--KKMKAENTRLCTKALGPSRTE 966
+E + I + EK+ + V LQ E +LK+ +E KMK E+ + L +
Sbjct: 1579 QESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMK-ESQEKEYQFLKMTAVN 1637
Query: 967 STQREKVC 974
TQ EK+C
Sbjct: 1638 ETQ-EKMC 1644
Score = 127 bits (318), Expect = 7e-29
Identities = 199/967 (20%), Positives = 406/967 (41%), Gaps = 122/967 (12%)
Query: 4 EAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQAL 63
E+ + + V+ L LQ +++ D K K + L EE + +H + Q
Sbjct: 1432 ESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEE 1491
Query: 64 AFEESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEEL--QTSYYSLRQYQSILEKQ 121
E V + ++ ++K+L + +L+ +E+ + ++++Q + EK
Sbjct: 1492 TINELRVNLSEKET----EISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEK- 1546
Query: 122 TSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALA---GDKIASLERSL 178
++L H K K+ + E +M +L +QE++ + +++ ++ +L
Sbjct: 1547 VNELKQFKEHRKAKDSALQSIESKM----LELTNRLQESQEEIQIMIKEKEEMKRVQEAL 1602
Query: 179 NLYRDKYQSSLSNI--ELLECQVKMLQGELGGIMGQEPEN--KGDHSKVRIYTSPCMIQE 234
+ RD+ + + I ++ E Q K Q + + E + +H K + T ++
Sbjct: 1603 QIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLEN 1662
Query: 235 HQETQKRLSEVWQKVSQQDDLIQELRNKL-ACSNALVLEREKALIKLQADFASCTATHRY 293
+ RL+++ + ++ + + R+ L + L +ER++ L+
Sbjct: 1663 IETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITR------- 1715
Query: 294 PPSSSEECEDIKKILKHLQEQKDS-------QCLHVEEYQNLVKDLRVELEAVSEQKRNI 346
E+ E++K + HL+E +++ E N+ KDL +A+ Q I
Sbjct: 1716 ---DLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKI 1772
Query: 347 MKDMMKLELDL----------HGLREETSAHIERKDKDITILQCRLQEL--QLEFTETQK 394
+++ + L G+ E + + KD+ +LQE +L+ E Q
Sbjct: 1773 QEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQL 1832
Query: 395 LTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAK----- 449
+TLKKD + E + + E+E+ Q+++ L K + +A +L ++E K
Sbjct: 1833 ITLKKD--VNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKE 1890
Query: 450 QDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQK 509
+D + E + L+ E +LK SL+E K ++ L QQ + K L+ H E + +K
Sbjct: 1891 RDNLRRVE-ETLKLERDQLKESLQETKARD-LEIQQ--ELKTARMLSKEHKETVDKLREK 1946
Query: 510 GLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKE 569
+K I ++Q++L + E + +K Q +K ++ L + E + E
Sbjct: 1947 ----ISEKTIQISDIQKDLDKSKDE--LQKKIQELQKKELQ--LLRVKEDVNMSHKKINE 1998
Query: 570 KRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEH 629
QL+K Q++ M + + + KL E L+E +++ +R++L++ KE
Sbjct: 1999 MEQLKKQFEAQNLSMQSV-------RMDNFQLTKKLHESLEEI-RIVAKERDELRRIKES 2050
Query: 630 EKLMEGELEALRQEFKKKDKT---LKENSRKLEEENENLRAELQCCSTQLESSLNKYNTS 686
K+ + A +E +D+ +K R L + ++L L+ ++++ L +Y+
Sbjct: 2051 LKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEM 2110
Query: 687 QQVIQ-------DLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSA 739
+ DL KEI QKE M ++A L YLQT ++ + A R
Sbjct: 2111 DDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLP------YLQTKHIEKLFTANQR--- 2161
Query: 740 ACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKL--------- 790
C + + ++KL +V S +++ + E + E + I E+ K+L
Sbjct: 2162 -CSMEFHRIMKKLKYVLSYVTKIKE---EQHESINKFEMDFIDEVEKQKELLIKIQHLQQ 2217
Query: 791 -----NTELRKLRGFHQESELEVHAFDKKLEEMSCQVL--QWQKQHQNDLKMLAAKEEQL 843
+ ELR L+ +Q +L + K E + ++Q+ N +M EE L
Sbjct: 2218 DCDVPSRELRDLK-LNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWL 2276
Query: 844 REFQEEMAALKENLLEDDKEPCCLPQW------SVPKDTCRLYRGNDQIMTNLEQWAKQQ 897
+ ++ LK + +++ C + + ++ ++ + I EQ K
Sbjct: 2277 NT-RFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSL 2335
Query: 898 KVANEKL 904
K NEKL
Sbjct: 2336 KEKNEKL 2342
Score = 105 bits (262), Expect = 2e-22
Identities = 162/831 (19%), Positives = 349/831 (41%), Gaps = 105/831 (12%)
Query: 173 SLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMI 232
++E LN R Y + + + E L + + ++ +L + K D +
Sbjct: 495 NIESELNSLRADYDNLVLDYEQLRTEKEEMELKL--------KEKNDLDEFEALERKTKK 546
Query: 233 QEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHR 292
+ + +S + V + Q+L N+L+ L+ E+E + KLQ
Sbjct: 547 DQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYI-------- 598
Query: 293 YPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMK 352
S++ E+IK L + E +E+ + + + L + E V+ + +
Sbjct: 599 ----DSQKLENIKMDLSYSLES-------IEDPKQMKQTL-FDAETVALDAKRESAFLRS 646
Query: 353 LELDLHGLREETSAHIERKDKDITILQCRLQ-----------ELQLEFTETQKLTLKKDK 401
L+L +E + ++ + DI + Q +L+ ELQ F E KLT D
Sbjct: 647 ENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDG 706
Query: 402 FLQEKDEMLQELEKKLTQVQNSLLKKEKE---LEKQQCMATELEMTVKEA----KQDKSK 454
+ + ELE K+T +Q L K+ +E L ++ + +EL+ E K+ + K
Sbjct: 707 KVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDK 766
Query: 455 EAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQ--KGLL 512
E + +E KL + + + + + ++ + K++ A + + T ++ Q K L
Sbjct: 767 SEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLH 826
Query: 513 LD-----KQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSD 567
+D K + + + +E+ L KE+ + + + + + EL E R+++
Sbjct: 827 MDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERL 886
Query: 568 KEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSK 627
E QL++ + +D + + RE+ I KL++ L+E K L +++ LK+ +
Sbjct: 887 NEMEQLKEQLENRDSTLQTV-------EREKTLITEKLQQTLEE-VKTLTQEKDDLKQLQ 938
Query: 628 EHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQ 687
E ++ E + L+ + + +L E+L+ + +T K S+
Sbjct: 939 ES---LQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTL------KSKISE 989
Query: 688 QVIQDLNKE--IALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDL 745
+V ++L+ E K+ +DK E Q T+T + D +++
Sbjct: 990 EVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQ-TLTADVKD----------NEI 1038
Query: 746 TQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEI-------IAYEERMKKLNTELRKLR 798
+ K+ + E LQQ L +K QL+ ++ I +E ++ L EL+K +
Sbjct: 1039 IEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQ 1098
Query: 799 GFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENL- 857
+ + + +L ++ + +++ + + L K++QL QEEM+ +++ +
Sbjct: 1099 EIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKIN 1158
Query: 858 ----LEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANE--KLGNQLREQ 911
L+++ + L + + L + ++ ++ K++KV E K R+
Sbjct: 1159 EIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDH 1218
Query: 912 VK-YIAKLSG----EKDHLHSVMVHLQQENK---KLKKEIEEKKMKAENTR 954
++ YI ++ K+ L +HL++ + +L++ + EK + NT+
Sbjct: 1219 LRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQ 1269
Score = 91.7 bits (226), Expect = 3e-18
Identities = 138/656 (21%), Positives = 276/656 (42%), Gaps = 96/656 (14%)
Query: 366 AHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKK--LTQVQNS 423
A ++R K+I L+ +L+E+ LE T Q + EKD++ Q LE+K L +VQN
Sbjct: 343 ALLKRYRKEIMDLKKQLEEVSLE-TRAQAM---------EKDQLAQLLEEKDLLQKVQN- 391
Query: 424 LLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNS---------LEE 474
EK + + T +T+++ + K K L ++ K+KNS
Sbjct: 392 ----EKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCL-GKINKMKNSNYADQFNIPTNI 446
Query: 475 AKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKE 534
+ +L+ + E +T L + K + ++ EL L+ +
Sbjct: 447 TTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRAD 506
Query: 535 SSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQ 594
+ R EE+ L+L E + D+ + +KT +Q+M++ + +K+
Sbjct: 507 YDNLVLDYEQLRTEKEEMELKLKEK----NDLDEFEALERKTKKDQEMQLIHEISNLKNL 562
Query: 595 HREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEH---EKL------MEGELEALRQEFK 645
+ LE +L +LL +K +Q+KK +E+ +KL + LE++ +
Sbjct: 563 VKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQ 622
Query: 646 KKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLM 705
K + L+ + E+ A L+ + +L+ + + T+ + +++ + Q E+
Sbjct: 623 MKQTLFDAETVALDAKRES--AFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKK 680
Query: 706 SLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQS 765
+Q L+K LQ + + T D K C +L + LQ+
Sbjct: 681 KMQVDLEKELQSA--FNEITKLTSLIDGKVPKDLLCNLEL----------EGKITDLQKE 728
Query: 766 LTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQW 825
L + E+ L EE+I E +K L +E+ +LR Q+ E+H + +++ +V+
Sbjct: 729 LNKEVEENEALREEVILLSE-LKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHK 787
Query: 826 QKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQ 885
+ + Q L E++ + ++++A + N D+E ++
Sbjct: 788 ESRVQGLL-------EEIGKTKDDLATTQSNYKSTDQE----------------FQNFKT 824
Query: 886 IMTNLEQWAKQQKVANEKLGNQL----REQVKYIAKLSGEKDHLHSVMVHLQQENKKLKK 941
+ + EQ K NE++ ++ +E K+ + L K L LQ++ +++++
Sbjct: 825 LHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQE 884
Query: 942 ---EIEEKKMKAENTRLCTKALGPSRTESTQREKVCGTLGWKGLPQDMGQRMDLTK 994
E+E+ K + EN S ++ +REK TL + L Q + + LT+
Sbjct: 885 RLNEMEQLKEQLENR--------DSTLQTVEREK---TLITEKLQQTLEEVKTLTQ 929
Score = 78.6 bits (192), Expect = 3e-14
Identities = 163/854 (19%), Positives = 343/854 (40%), Gaps = 118/854 (13%)
Query: 12 VSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEESEVE 71
VS KL ++Q D++N + + + + L+ N+ + + D + Q E +++
Sbjct: 1797 VSEKTDKLSNMQKDLENSNAKLQEKIQELKANE---HQLITLKKDVNETQKKVSEMEQLK 1853
Query: 72 FGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYY---SLRQYQSILEKQTSDLVLL 128
Q L +L+ + L L Q+L + EE+++ +LR+ + L+ + L
Sbjct: 1854 KQIKDQS--LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKES 1911
Query: 129 HHHCKLKEDEV---ILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKY 185
K ++ E+ + + ++ T +KL +E+++ +I+ +++ L+ +D+
Sbjct: 1912 LQETKARDLEIQQELKTARMLSKEHKETVDKL---REKISEKTIQISDIQKDLDKSKDEL 1968
Query: 186 QSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEV 245
Q + ++ E Q+ ++ ++ M + N+ + K + +Q + +L++
Sbjct: 1969 QKKIQELQKKELQLLRVKEDVN--MSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKK 2026
Query: 246 WQKVSQQDDLIQELRNKLA-CSNALVLEREKALIKLQADFASCTATHRYPP--------- 295
+ ++ ++ + R++L +L +ER++ + L+ A H+ P
Sbjct: 2027 LHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQ 2086
Query: 296 -----SSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDM 350
S E+C IK++LK E D H E L DL E+E E + ++
Sbjct: 2087 QHLTESLREKCSRIKELLKRYSEMDD----HYECLNRLSLDLEKEIEFQKELSMRVKANL 2142
Query: 351 MKLELDLHGLREETSAH---------IERKDKDITILQCRLQELQ-----------LEFT 390
L + + +A+ I +K K + +++E Q ++
Sbjct: 2143 SLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEV 2202
Query: 391 ETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELE-----KQQCMATELEMTV 445
E QK L K + LQ+ ++ + L QN L E+ L+ + + TE + +
Sbjct: 2203 EKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVL 2262
Query: 446 KEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQ---------ERLAA--QQAAQCKEEAA 494
K+ E + +++KLKN +++ + R+ A ++ + +E +A
Sbjct: 2263 SNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSA 2322
Query: 495 LAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQM-LQKESSMAEKEQTSNRKRVEELS 553
E + L K+K + + + + L+ L + + Q + V +
Sbjct: 2323 TISKEWEQDLKSL-------KEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRA 2375
Query: 554 LELS-EALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEA 612
+L+ E +R+LENS E + E M + +++ + I KL+ + E+
Sbjct: 2376 TQLTTEKIRELENSLHEAK-------ESAMHKESKIIKMQKELEVTNDIIAKLQAKVHES 2428
Query: 613 TKLLEDKREQLKKSKEHEKL----MEGELEALRQEFKKKDKTLKENSRKLEEE------- 661
K LE +E ++ ++ L + E+E L+ + K D +N+++ E+E
Sbjct: 2429 NKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKAT 2488
Query: 662 -----------NENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQ 710
ENLR Q T + S S + + +Q + L+++
Sbjct: 2489 VEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSE 2548
Query: 711 ---LDKALQKEKHYLQTTITKEAYDALSRKSAACQD-----DLTQALEKLNHVTSETKSL 762
L+K + K K + I K+ + LS + + T E VT E
Sbjct: 2549 HIRLEKEISKLKQQNEQLI-KQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPK 2607
Query: 763 QQSLTQTQEKKAQL 776
+T T KK Q+
Sbjct: 2608 SPKVTGTASKKKQI 2621
Score = 64.3 bits (155), Expect = 5e-10
Identities = 143/784 (18%), Positives = 313/784 (39%), Gaps = 140/784 (17%)
Query: 1 MKDEAGERDREVSSL--------NSKLLSLQLDIKNL------HDVCKRQRKTLQ--DNQ 44
+K + E ++VS + + L +L+I+NL H+ + + ++ DN
Sbjct: 1835 LKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNL 1894
Query: 45 LCMEEAMNSSHD--KKQAQALAFEESEV--EFGSSKQC---HLRQLQQLKKKLLV----- 92
+EE + D K+ Q + E+ E +++ H + +L++K+
Sbjct: 1895 RRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQI 1954
Query: 93 --LQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLHHHCKLKEDEVILYEEEMGN-- 148
+Q++L+ +ELQ L++ + L + D+ + H K+ E E + + E N
Sbjct: 1955 SDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHK--KINEMEQLKKQFEAQNLS 2012
Query: 149 ------HNENTGEKLHLAQEQLALAG---DKIASLERSLNLYRDKYQSSLSNIELLECQV 199
N +KLH + E++ + D++ ++ SL + RD++ ++L + + Q
Sbjct: 2013 MQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQN 2072
Query: 200 KMLQGELGGIM-GQEPENKGDHSKV----RIYTSPCMIQEHQETQKRLS-EVWQKVSQQD 253
++ E + GQ+ + K + + +H E RLS ++ +++ Q
Sbjct: 2073 HQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQK 2132
Query: 254 DLIQELRNKLA--------------CSNALVLEREKALIKLQADFASCT--------ATH 291
+L ++ L+ + +E + + KL+ + T + +
Sbjct: 2133 ELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESIN 2192
Query: 292 RYPPSSSEECEDIKKIL---KHLQEQKD-------------SQCLHVEEY-----QNLVK 330
++ +E E K++L +HLQ+ D + LH+EE ++
Sbjct: 2193 KFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFP 2252
Query: 331 DLRVELEAVSEQKRNI---MKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQL 387
++ E + V ++ + +++ + D+ L+ +R + R+ +
Sbjct: 2253 SIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMN 2312
Query: 388 EFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKE 447
E TE ++ + K E Q+L K L + L K + L+ ++ T ++
Sbjct: 2313 ESTEFEERSATISK------EWEQDL-KSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQD 2365
Query: 448 AKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKL 507
K + ++++L+NSL EAK+ + + ++E + + Q K+
Sbjct: 2366 NKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKV 2425
Query: 508 QKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEA-LRKLENS 566
+ ++ +TIQ LQ ++ + K ++ +E+L ++L + L K++N+
Sbjct: 2426 HESNKCLEKTKETIQVLQDKVALGAK----------PYKEEIEDLKMKLVKIDLEKMKNA 2475
Query: 567 ---DKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGS---------------IKCKLEED 608
+KE + TV Q + + + ++ + Q + + C
Sbjct: 2476 KEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSG 2535
Query: 609 LQEATKLLEDKREQLKKSKEHEKL---------MEGELEALRQEFKKKDKTLKENSRKLE 659
+ + TK L K E ++ KE KL + EL + Q + KT KE + K E
Sbjct: 2536 IVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKRE 2595
Query: 660 EENE 663
+
Sbjct: 2596 AHKQ 2599
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 135 bits (340), Expect = 2e-31
Identities = 222/1077 (20%), Positives = 440/1077 (40%), Gaps = 238/1077 (22%)
Query: 23 QLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEESEVEFGSSKQCH-LR 81
Q +++ L + C+++++TL ++ + +A ++K + L +++E+E SS+ L+
Sbjct: 639 QTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLK 698
Query: 82 QLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLHHHCKLKEDEVIL 141
+L+++L VL+ + + +EL+ + + +Q D ++ H ++ E L
Sbjct: 699 ARHKLEEELSVLKDQTDKMKQELEAKMDEQKNH----HQQQVDSIIKEHEVSIQRTEKAL 754
Query: 142 YEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKY-QSSLSNIELLECQVK 200
D+I LE L RDK+ + +++E LE +K
Sbjct: 755 --------------------------KDQINQLELLLK-ERDKHLKEHQAHVENLEADIK 787
Query: 201 MLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELR 260
+GEL Q+ K D + Q +Q S ++ ++ + +L+
Sbjct: 788 RSEGEL-----QQASAKLD-----------VFQSYQ------SATHEQTKAYEEQLAQLQ 825
Query: 261 NKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCL 320
KL L LE E+ L+ Q + ++ QK C
Sbjct: 826 QKL-----LDLETERILLTKQ--------------------------VAEVEAQKKDVCT 854
Query: 321 HVEEYQNLVKDLRVELE---AVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITI 377
++ ++ V+DL +LE + EQK + + + +L+ G +E+ +K+ I
Sbjct: 855 ELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLE-DGNKEQEQTKQILVEKENMI 913
Query: 378 LQCRL-QELQLEFTETQKLTLKKDKF----------LQEKDEMLQELEKKLTQVQNSLLK 426
LQ R Q+ ++E TQKL+ K+D + +++ ++++++K ++Q +L
Sbjct: 914 LQMREGQKKEIEIL-TQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETL-- 970
Query: 427 KEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQA 486
K+K L+++ + ELE T E Q K K+ K L+ NS + RL Q
Sbjct: 971 KKKLLDQEAKLKKELENTALELSQ-KEKQFNAKMLE---MAQANSAGISDAVSRLETNQK 1026
Query: 487 AQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAE------- 539
Q + + L D +K L Q+A+ +QE+ E+Q+ +KE +AE
Sbjct: 1027 EQIESLTEVHRRELNDVISIWEKKL---NQQAEELQEI-HEIQLQEKEQEVAELKQKILL 1082
Query: 540 -----KEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQ 594
+E ++E ++ L +L+ K+K ++A+ + K+ L++++
Sbjct: 1083 FGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVD 1142
Query: 595 HREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKEN 654
+ L+E L E L E+ + ++ + K + E ++L+ +K +K+L++
Sbjct: 1143 LNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDK 1202
Query: 655 SRKLEEENENLRAELQCCSTQLES------------SLNKYNTSQQVIQDLNKEIALQKE 702
S + ++ +E L +L C + E+ S +K N I KE
Sbjct: 1203 SLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKE 1262
Query: 703 SLM-------SLQAQLDK----------ALQKEKHYL-----QTTITKEAYDALSRKSAA 740
+L+ L+AQL + + Q+ H L Q K ++L + A
Sbjct: 1263 ALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEA 1322
Query: 741 CQ----DDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEE---EIIAYEERMKKLNTE 793
Q + A EK + +T K L +++ K +L+E EI + +++ LN +
Sbjct: 1323 LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382
Query: 794 LRKLRGFHQESELEVHAFDKKLEEMSCQVL------------------------------ 823
L+ E E + + K+ +E C++L
Sbjct: 1383 LQNSISL-SEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNK 1441
Query: 824 --QWQK-------QHQNDLK----MLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQW 870
+W+K QHQN +K L K ++ E E++ LKE L + +K CL +
Sbjct: 1442 FSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCL-KG 1500
Query: 871 SVPKDTCRLYRGNDQIMT----------NLEQWAKQQKVANEKLGNQLR----------- 909
+ D ++ + + T LE Q+ + E L L+
Sbjct: 1501 EMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHK 1560
Query: 910 ---EQVKYIAKLSGEKDH----LHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKA 959
+++++ +L EKD+ ++ L+ + +K E+E KK + E+ L K+
Sbjct: 1561 ELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKS 1617
Score = 129 bits (325), Expect = 1e-29
Identities = 190/916 (20%), Positives = 399/916 (43%), Gaps = 105/916 (11%)
Query: 67 ESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLV 126
E+E G+S + QL Q +++ EL T+Y L++ EK+ +
Sbjct: 123 EAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQR-----EKKKLQGI 177
Query: 127 LLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDK---IASLERSLNLYRD 183
L K L EE + K HL +E A +K I+ L+ ++L +
Sbjct: 178 LSQSQDKSLRRIAELREELQMDQQA----KKHLQEEFDASLEEKDQYISVLQTQVSLLKQ 233
Query: 184 KYQSSLSNIELLECQVKMLQGELGGIMGQE-PENKGDHSKVRIYTSPCMIQEHQETQKRL 242
+ ++ N+++L+ + L+ + +E PE+ G+ + E + K L
Sbjct: 234 RLRNGPMNVDVLK-PLPQLEPQAEVFTKEENPESDGEP-----------VVEDGTSVKTL 281
Query: 243 SEVWQKVSQQDDLIQELRNKLAC--SNALVLEREKALIKLQADFASCTATHRYPPSSSEE 300
+ Q+V +Q++L++ + + +L EK ++ Q D E
Sbjct: 282 ETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLD---------------ER 326
Query: 301 CEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAV-SEQKRNIMKDMMKLELDLHG 359
++++KI +K + + +NL++ L + V +E KR + + + E ++
Sbjct: 327 LQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQ 386
Query: 360 LREE----TSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEK 415
LR T+ E +++ + +EL+ + QK + K E DE ++ +EK
Sbjct: 387 LRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEK 446
Query: 416 KLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEA 475
+ + SL ++ ++++ + + AK K E E + E+ K + E
Sbjct: 447 TSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRERE 506
Query: 476 KQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLL----LDKQKADTIQELQRELQML 531
Q++ A + +Q + +L+ +Q K Q+ L L+ QK + E + +L+ L
Sbjct: 507 FQEQMKVALEKSQSE--------YLKISQEKEQQESLALEELELQKKAILTESENKLRDL 558
Query: 532 QKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRI 591
Q+E+ + R R+ EL L ++L++ +N K+ L + + K N + +
Sbjct: 559 QQEAE-------TYRTRILELESSLEKSLQENKNQSKD---LAVHLEAEKNKHNKEITVM 608
Query: 592 KHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTL 651
+H K +LE + L +K + LK+ + E+E LR++ +++ +TL
Sbjct: 609 VEKH------KTELESLKHQQDALWTEKLQVLKQQ------YQTEMEKLREKCEQEKETL 656
Query: 652 KENSR-----KLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMS 706
++ +EE NE +L T+LES ++ + + L +E+++ K+
Sbjct: 657 LKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDK 716
Query: 707 LQAQLDKALQKEKHYLQ---TTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQ 763
++ +L+ + ++K++ Q +I KE ++ R A +D + Q LE L K
Sbjct: 717 MKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQ-LELL------LKERD 769
Query: 764 QSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVL 823
+ L + Q LE +I E +++ + +L + + + + A++++L ++ ++L
Sbjct: 770 KHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL 829
Query: 824 QWQKQHQNDLKMLAAKEEQLREFQEEMAALK---ENLLEDDKEPCCLPQWSVPKDTCRLY 880
+ + K +A E Q ++ E+ A K ++L++ ++ + V K ++Y
Sbjct: 830 DLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKV-KSLTQVY 888
Query: 881 RGNDQIMTNLEQWAKQQKVANEKLGNQLREQVK-----YIAKLSGEKDHLHSVMVHLQQE 935
+ ++ KQ V E + Q+RE K KLS ++D +H + + +
Sbjct: 889 ESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETK 948
Query: 936 NKKLKKEIEEKKMKAE 951
K +K++E+ K KA+
Sbjct: 949 FKNQEKKMEKVKQKAK 964
Score = 121 bits (304), Expect = 3e-27
Identities = 209/1057 (19%), Positives = 447/1057 (42%), Gaps = 179/1057 (16%)
Query: 1 MKDEAGERDREVSSLNSKLLSLQLDIKNLH-DVCKRQRKTLQDNQLCMEEAMNSSHDKKQ 59
++++ ++ V+SL L+ ++ L D+ K ++ + +E M + DK++
Sbjct: 1111 LQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRK 1170
Query: 60 AQALA--FEESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSY-YSLRQYQS 116
L + ++ EF S K H + + L+ K L E + +EEL ++ ++
Sbjct: 1171 VSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSL----EFKKLSEELAIQLDICCKKTEA 1226
Query: 117 ILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLER 176
+LE +T++L+ + K + ++ + E L + ++ ++ L
Sbjct: 1227 LLEAKTNELINISSS---KTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTE 1283
Query: 177 SLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEP---ENKGDHSKVRIYTSPCMIQ 233
N +Q + +E E Q+K ++ ++ ++ ++ + G+ + C+ Q
Sbjct: 1284 EQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQ 1343
Query: 234 EHQETQKRLS--------------EVWQKVSQQDDLIQELRNKLACSNALVLEREKALIK 279
+E + ++ E+ Q DL +L+N ++ S E+E A+
Sbjct: 1344 LKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLS-----EKEAAISS 1398
Query: 280 L--QADFASCTA-------THRYPPSSSEECEDIKKI---LKHLQEQKDSQCLHVEEYQN 327
L Q D C + + S E+ ++++ E K ++QN
Sbjct: 1399 LRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQN 1458
Query: 328 LVKDLRVELEAVSEQ--KRNIMKDMMKLELD--------LHGLREETSAHIERKDKDI-T 376
VK+L+++LE S++ +++ +++K ELD L G E+ + +E+K+ ++ T
Sbjct: 1459 TVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLET 1518
Query: 377 ILQ---CRLQELQLEFT----------------------ETQKLTLKKDKFLQ---EKDE 408
L+ R+ EL+ T E ++L K F + EKD
Sbjct: 1519 ELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDN 1578
Query: 409 MLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKL 468
++E E+K+ ++N + + ELE ++ + ++VK SKE E KAL+ ++
Sbjct: 1579 RVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVK------SKEEELKALEDRLES- 1631
Query: 469 KNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADT-IQELQRE 527
S + + +R A Q+ A K++ +E+ + + +KG + +T +QE +RE
Sbjct: 1632 -ESAAKLAELKRKAEQKIAAIKKQLL---SQMEEKEEQYKKGTESHLSELNTKLQERERE 1687
Query: 528 LQMLQKESSMAEKEQTSN-----------------------------RKRVEELSLELSE 558
+ +L+++ E Q+ +++ L L+E
Sbjct: 1688 VHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTE 1747
Query: 559 ALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKH----QHREQGSIKCKLEEDLQEATK 614
+ L+ +EK + + E + + L +++H QH +Q I L+E+L+E K
Sbjct: 1748 KEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIG-HLQEELEEKNK 1806
Query: 615 LLE------DKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAE 668
++E K + + ++ +E + +++ ++K+ T + +K++E + L +
Sbjct: 1807 KYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQ 1866
Query: 669 LQCCSTQLESSLNKYNTSQQVIQ--------DLNKEIALQKESLMSLQAQLDKALQKEKH 720
+ ++E +KY Q + Q +L +E +K +Q +L ++ + +
Sbjct: 1867 KEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHN 1926
Query: 721 YLQTTIT--KEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEE 778
L+ + + L ++ Q DL + L K + E + L++ Q +E+K + E+
Sbjct: 1927 DLEFKLAGAEREKQKLGKEIVRLQKDL-RMLRKEHQ--QELEILKKEYDQEREEKIKQEQ 1983
Query: 779 EII------AYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQN- 831
E + ++ M++ NT+L + QE E+ + K +E+ ++L+ ++ N
Sbjct: 1984 EDLELKHNSTLKQLMREFNTQLAQKE---QELEMTIKETINKAQEVEAELLESHQEETNQ 2040
Query: 832 ----------DLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYR 881
DLK A + E++ + +EE K L+ E L + K
Sbjct: 2041 LLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEE--LQKKYQQKLEQEENP 2098
Query: 882 GND-----QIMTNLEQWAKQQKVANEKLGNQ-LREQV 912
GND ++ T L Q K +++ KL Q REQ+
Sbjct: 2099 GNDNVTIMELQTQLAQ--KTTLISDSKLKEQEFREQI 2133
Score = 120 bits (302), Expect = 5e-27
Identities = 206/959 (21%), Positives = 406/959 (42%), Gaps = 131/959 (13%)
Query: 9 DREVSSLNSKLLSLQLDIKNL-----------HDVCKR-QRKTLQDNQLCME-EAMNSSH 55
+ +++ L KLL L+ + L DVC +Q L + E NS
Sbjct: 818 EEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEM 877
Query: 56 DKKQAQALAFEESEVEFGSSKQCHLRQLQQLKKKLLVLQ------QELEFHTEELQTSYY 109
++K ES++E G+ +Q +Q+ ++K+ ++LQ +E+E T++L
Sbjct: 878 EQKVKSLTQVYESKLEDGNKEQEQTKQIL-VEKENMILQMREGQKKEIEILTQKLSAKED 936
Query: 110 SLR----QYQSILEKQTSDLVLLHHHCKLKED----EVILYEEEMGNHNENTG------- 154
S+ +Y++ + Q + + K ++ +++ E ++ ENT
Sbjct: 937 SIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKE 996
Query: 155 -----EKLHLAQEQLALAGDKIASLERS----LNLYRDKYQSSLSNI-----ELLECQVK 200
+ L +AQ A D ++ LE + + + ++ L+++ + L Q +
Sbjct: 997 KQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAE 1056
Query: 201 MLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQD----DLI 256
LQ E+ I QE E + K +I C E +E K ++ + ++ +QD +L
Sbjct: 1057 ELQ-EIHEIQLQEKEQEVAELKQKILLFGC---EKEEMNKEITWLKEEGVKQDTTLNELQ 1112
Query: 257 QELRNKLACSNALVLEREKA---LIKLQADFASCTATHRYPPSSSEEC-----EDIKKIL 308
++L+ K A N+L + K L KL+ D + + E ED +K+
Sbjct: 1113 EQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVS 1172
Query: 309 KHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHI 368
+ + K + EE+Q+L +++ ++ K +L + L ++T A +
Sbjct: 1173 ELTSKLKTTD----EEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALL 1228
Query: 369 ERKDKD-ITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELE---KKLTQVQNSL 424
E K + I I + + + Q T K + L K + ELE ++LT+ QN+L
Sbjct: 1229 EAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTL 1288
Query: 425 ----------LKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAE--VQKLKNSL 472
L++++ K E +T KEA Q + + A + E + +LK L
Sbjct: 1289 NISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKEL 1348
Query: 473 EEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQ---------- 522
E L ++ + K E + L D +LQ + L +++A
Sbjct: 1349 SENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKC 1408
Query: 523 ELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLE-------NSDKEKR-QLQ 574
EL ++Q L + KE+ S ++V++ S + SE +K + N+ KE + QL+
Sbjct: 1409 ELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLE 1468
Query: 575 ---KTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEK 631
K E+D ++N + + + Q++ +K ++E+D + K + +LK
Sbjct: 1469 LKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIM 1528
Query: 632 LMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQ 691
+E + E + ++ LK +++ + E++ L +LQ E N+ +++ I
Sbjct: 1529 ELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKIL 1588
Query: 692 DLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEK 751
L ++ K L + + +L+ K + K D L +SAA L + K
Sbjct: 1589 TLENQVYSMKAELETKKKELEHVNLSVKS--KEEELKALEDRLESESAA---KLAELKRK 1643
Query: 752 LNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAF 811
+ K +Q L+Q +EK+ Q ++ E + +LNT+L QE E EVH
Sbjct: 1644 AEQKIAAIK--KQLLSQMEEKEEQYKK---GTESHLSELNTKL-------QEREREVHIL 1691
Query: 812 DKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQ--------LREFQEEMAALKENLLEDDK 862
++KL+ + + ++ + A E++ + ++E+++ L+ NL E +K
Sbjct: 1692 EEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEK 1750
Score = 113 bits (282), Expect = 1e-24
Identities = 214/1041 (20%), Positives = 445/1041 (42%), Gaps = 192/1041 (18%)
Query: 1 MKDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQD-----NQLCMEEAMNSSH 55
+K A E R+VS L SKL + + ++L ++ K+L+D +L E A+
Sbjct: 1160 LKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDI 1219
Query: 56 DKKQAQAL--AFEESEVEFGSSK---------QCHLRQLQQLKKKLLV-------LQQEL 97
K+ +AL A + SSK C R ++K+ LL+ L+ +L
Sbjct: 1220 CCKKTEALLEAKTNELINISSSKTNAILSRISHCQHR-TTKVKEALLIKTCTVSELEAQL 1278
Query: 98 EFHTEELQTSYYSLRQYQSILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKL 157
TEE T S +Q LE++ + + + + E ++E GN + EK
Sbjct: 1279 RQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEK- 1337
Query: 158 HLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENK 217
E + + + +++ + L++ ++K + E+ + Q +
Sbjct: 1338 -----------------ESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTD-- 1378
Query: 218 GDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKAL 277
V++ S + ++ + ++ + D +Q+L K+ L +EK
Sbjct: 1379 ---LNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVD-----TLSKEKI- 1429
Query: 278 IKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELE 337
S+ E+ +D +++ S+ ++QN VK+L+++LE
Sbjct: 1430 ------------------SALEQVDDWSNKFSEWKKKAQSR---FTQHQNTVKELQIQLE 1468
Query: 338 AVSEQ--KRNIMKDMMKLELD--------LHGLREETSAHIERKDKDI-TILQ---CRLQ 383
S++ +++ +++K ELD L G E+ + +E+K+ ++ T L+ R+
Sbjct: 1469 LKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIM 1528
Query: 384 ELQLEFT----------------------ETQKLTLKKDKFL---QEKDEMLQELEKKLT 418
EL+ T E ++L K F +EKD ++E E+K+
Sbjct: 1529 ELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKIL 1588
Query: 419 QVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQ 478
++N + + ELE ++ + ++V KSKE E KAL+ ++ S + +
Sbjct: 1589 TLENQVYSMKAELETKKKELEHVNLSV------KSKEEELKALEDRLE--SESAAKLAEL 1640
Query: 479 ERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADT-IQELQRELQMLQKESSM 537
+R A Q+ A K++ +E+ + + +KG + +T +QE +RE+ +L+++
Sbjct: 1641 KRKAEQKIAAIKKQLL---SQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKS 1697
Query: 538 AEKEQT-------SNRKRVEELSLELSEALRKLENSDKEK-RQLQKTVAEQDMKMNDMLD 589
E Q+ S + E +++ ++ + +EK LQ+ + E++ +L
Sbjct: 1698 VESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKE----KLLQ 1753
Query: 590 RIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHE-KLMEGELEALRQEFKKKD 648
R+ + E S ++ QE LE ++K+HE + M G L+ +E KK
Sbjct: 1754 RVGQEKEETVSSHFEMRCQYQERLIKLEH-----AEAKQHEDQSMIGHLQEELEEKNKKY 1808
Query: 649 KTLKENSRKLEEENENLRAE--LQCCSTQLESSLNKYNTSQQVIQDLNKEI--------- 697
+ + E N++A+ L+ ++ +L + + Q+++ KE+
Sbjct: 1809 SLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKE 1868
Query: 698 --ALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHV 755
++ E L S +L Q + T + +E + S KS Q L L+++
Sbjct: 1869 VHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKS-KSHLVQPKL------LSNM 1921
Query: 756 TSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEV--HAFDK 813
++ L+ L + +K +L +EI+ +L +LR LR HQ+ ELE+ +D+
Sbjct: 1922 EAQHNDLEFKLAGAEREKQKLGKEIV-------RLQKDLRMLRKEHQQ-ELEILKKEYDQ 1973
Query: 814 KLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVP 873
+ EE Q+Q +LK + ++ +REF ++A ++ L + ++
Sbjct: 1974 EREEKI-----KQEQEDLELKHNSTLKQLMREFNTQLAQKEQEL-----------EMTIK 2017
Query: 874 KDTCRLYRGNDQIMTNLEQWAKQ--QKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVH 931
+ + +++ + ++ Q +K+A EK + R +Y L ++ + + +
Sbjct: 2018 ETINKAQEVEAELLESHQEETNQLLKKIA-EKDDDLKRTAKRYEEILDAREEEMTAKVRD 2076
Query: 932 LQQENKKLKKEIEEKKMKAEN 952
LQ + ++L+K+ ++K + EN
Sbjct: 2077 LQTQLEELQKKYQQKLEQEEN 2097
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 134 bits (338), Expect = 3e-31
Identities = 225/1033 (21%), Positives = 453/1033 (43%), Gaps = 155/1033 (15%)
Query: 4 EAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQAL 63
E ER + +N++L + + + L D C +K + D +L + + H
Sbjct: 927 EVTERAEDEEEINAELTAKK---RKLEDECSELKKDIDDLELTLAKVEKEKHAT------ 977
Query: 64 AFEESEVEFGSSKQCHLRQ-LQQLKKKLLVLQQELEFHTEELQTS---YYSLRQYQSILE 119
E++V+ + + L + + +L K+ LQ+ + ++LQ +L + + LE
Sbjct: 978 ---ENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLE 1034
Query: 120 KQTSDLV-LLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSL 178
+Q DL L KL+ D + G+ L LAQE + ++ L+ L
Sbjct: 1035 QQVDDLEGSLEQEKKLRMDLERAKRKLEGD--------LKLAQESIMDIENEKQQLDEKL 1086
Query: 179 NLYRDKYQSSLSNIE-------LLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCM 231
+ + S IE L+ ++K LQ + + + + +K S +
Sbjct: 1087 KKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD-L 1145
Query: 232 IQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATH 291
+E +E +RL E S Q ++ NK + + R+ LQ + + T
Sbjct: 1146 SRELEEISERLEEAGGATSAQIEM-----NKKREAEFQKMRRDLEEATLQHEATAATLRK 1200
Query: 292 RYPPSSSE---ECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMK 348
++ S +E + ++++++ + L+++K + ++ DL +E VS+ K N+ K
Sbjct: 1201 KHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID-------DLASNVETVSKAKGNLEK 1253
Query: 349 DMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTE--------TQKLTLKKD 400
LE L L+ + +R D+T + RLQ EF+ +L+ K
Sbjct: 1254 MCRTLEDQLSELKSKEEEQ-QRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQ 1312
Query: 401 KFLQEKDEMLQELEKKLTQVQNSL------------LKKEKELEKQQCMATELEMTVKEA 448
F Q+ +E+ ++LE+++ + +N+L L +E+ E+Q+ A EL+ + +A
Sbjct: 1313 AFTQQIEELKRQLEEEI-KAKNALAHALQSSRHDCDLLREQYEEEQESKA-ELQRALSKA 1370
Query: 449 KQDKSK---EAECKALQAEVQKLKNSLEEAKQQ--ERLAAQQAAQCKEEAALAGC-HLED 502
+ ++ + E A+Q + LEEAK++ +RL QAA+ EA A C LE
Sbjct: 1371 NTEVAQWRTKYETDAIQRTEE-----LEEAKKKLAQRL---QAAEEHVEAVNAKCASLEK 1422
Query: 503 TQRKLQ---KGLLLDKQKADTI----------------------QELQRELQMLQKESSM 537
T+++LQ + L+LD ++ + +E EL+ QKE+
Sbjct: 1423 TKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARS 1482
Query: 538 AEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHRE 597
E + EE +L R+ +N +E L + +AE ++++ L++IK Q +
Sbjct: 1483 LGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHE-LEKIKKQVEQ 1541
Query: 598 QGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRK 657
+ KC+L+ L+EA LE E K++ +LE L Q + D+ + E +
Sbjct: 1542 E---KCELQAALEEAEASLEH---------EEGKILRIQLE-LNQVKSEVDRKIAEKDEE 1588
Query: 658 LEEENENLRAELQCCSTQLESSLNKYNTS----QQVIQDLNK-EIALQKESLMSLQAQLD 712
+++ N ++ + L++ + N + +++ DLN+ EI L + M+ +A
Sbjct: 1589 IDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL-- 1646
Query: 713 KALQKEKHYLQTT-ITKEAY----DALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLT 767
++Y T I K+ DAL R ++ L + N + +E + L+ +L
Sbjct: 1647 ------RNYRNTQGILKDTQIHLDDAL-RSQEDLKEQLAMVERRANLLQAEIEELRATLE 1699
Query: 768 QTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQK 827
QT+ + E+E++ ER++ L+T+ L ++ E ++ ++E++ + ++
Sbjct: 1700 QTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEE 1759
Query: 828 QHQNDLKMLAAKEEQLREFQEEMAAL---KENLLEDDKEPCCLPQWSVPKDTCRLYRGND 884
+ + + A E+L++ Q+ A L K+N+ + K+ L + L G
Sbjct: 1760 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKD---LQLRLDEAEQLALKGGKK 1816
Query: 885 QI------MTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQENKK 938
QI + LE + ++ N + LR+ + + +L+ + + ++ LQ K
Sbjct: 1817 QIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDK 1876
Query: 939 LKKEIEEKKMKAE 951
L+ +++ K +AE
Sbjct: 1877 LQAKVKSYKRQAE 1889
Score = 104 bits (259), Expect = 5e-22
Identities = 148/741 (19%), Positives = 311/741 (41%), Gaps = 91/741 (12%)
Query: 272 EREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVK- 330
E EK + ++ +F + +E E+ K++ L+E+ D Q E + L
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEE--KMVTLLKEKNDLQLQVQAEAEGLADA 907
Query: 331 --------DLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRL 382
+++LEA ++ +D ++ +L + + KDI L+ L
Sbjct: 908 EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 967
Query: 383 QELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQ-----------------NSLL 425
+++ E T+ + + DE + +L K+ +Q N+L
Sbjct: 968 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLT 1027
Query: 426 KKEKELEKQQCMATELEMTVKEAKQDK-SKEAECKALQAEVQKLKNSLEEAKQQERLAAQ 484
K + +LE+Q +LE ++++ K+ + E + L+ +++ + S+ + + +++ +
Sbjct: 1028 KAKIKLEQQ---VDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDE 1084
Query: 485 QAAQCKEEAALAGCHLEDTQR---KLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKE 541
+ + + E + +ED Q +LQK + K+ I+EL+ E++ + + AEK+
Sbjct: 1085 KLKKKEFEISNLQSKIEDEQALGIQLQKKI---KELQARIEELEEEIEAERASRAKAEKQ 1141
Query: 542 QTSNRKRVEELSLELSEA----LRKLENSDKEKRQLQK--------------TVAEQDMK 583
++ + +EE+S L EA ++E + K + + QK T A K
Sbjct: 1142 RSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1201
Query: 584 MNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLED---KREQLKKSKEHEKLMEGELEAL 640
D + + Q +K KLE++ E ++D E + K+K + + M LE
Sbjct: 1202 HADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQ 1261
Query: 641 RQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQL---ESSLNKYNTSQQVIQDLNKEI 697
E K K++ + L + L+ E S QL E+ +++ + +Q +E+
Sbjct: 1262 LSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEEL 1321
Query: 698 ALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLN---- 753
Q E + + L ALQ +H + +E Y+ A +L +AL K N
Sbjct: 1322 KRQLEEEIKAKNALAHALQSSRH--DCDLLREQYEEEQESKA----ELQRALSKANTEVA 1375
Query: 754 --HVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAF 811
ET ++Q++ + +E K +L + + A EE ++ +N + L Q + EV
Sbjct: 1376 QWRTKYETDAIQRT-EELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDL 1434
Query: 812 DKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWS 871
+E + K+ +N K+LA +++ E E+ A ++ S
Sbjct: 1435 MLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEAR------------S 1482
Query: 872 VPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVH 931
+ + ++ ++ + LE ++ N+ L ++ + + IA+ L +
Sbjct: 1483 LGTELFKIKNAYEESLDQLETLKRE----NKNLQQEISDLTEQIAEGGKRIHELEKIKKQ 1538
Query: 932 LQQENKKLKKEIEEKKMKAEN 952
++QE +L+ +EE + E+
Sbjct: 1539 VEQEKCELQAALEEAEASLEH 1559
Score = 104 bits (259), Expect = 5e-22
Identities = 192/912 (21%), Positives = 386/912 (42%), Gaps = 141/912 (15%)
Query: 21 SLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQA-QALAFEESEVEFGSSKQCH 79
SL+ + K D+ + +RK D +L E M+ ++K+Q + L +E E+ S+ Q
Sbjct: 1043 SLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEI---SNLQSK 1099
Query: 80 LRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLHHHCKLKEDEV 139
+ Q L +L +EL+ EEL+ + R ++ EKQ SDL + +E
Sbjct: 1100 IEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEA 1159
Query: 140 ---ILYEEEMGNHNENTGEKLHLAQEQLALA-------------------GDKIASLER- 176
+ EM E +K+ E+ L G++I +L+R
Sbjct: 1160 GGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRV 1219
Query: 177 SLNLYRDKYQSSL------SNIEL-------LECQVKMLQGELGGIMGQEPE-----NKG 218
L ++K + + SN+E LE + L+ +L + +E E N
Sbjct: 1220 KQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDL 1279
Query: 219 DHSKVRIYTSPC----MIQEHQETQKRLSEVWQKVSQQ-DDLIQELRNKLACSNALV--- 270
+ R+ T + E + +LS Q +QQ ++L ++L ++ NAL
Sbjct: 1280 TAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHAL 1339
Query: 271 ---------------------LEREKALIKLQADFASCTATHRYPP-SSSEECEDIKKIL 308
E ++AL K + A + +EE E+ KK L
Sbjct: 1340 QSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKL 1399
Query: 309 -KHLQ------EQKDSQCLHVEE----YQNLVKDLRVELE-------AVSEQKRNIMKDM 350
+ LQ E +++C +E+ QN V+DL +++E A+ +++RN K +
Sbjct: 1400 AQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKIL 1459
Query: 351 MKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTET--QKLTLKKD-KFLQEKD 407
+ + EET A +E K+ L L +++ + E+ Q TLK++ K LQ++
Sbjct: 1460 AEWKQKC----EETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEI 1515
Query: 408 EMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQD-KSKEAECKALQAEVQ 466
L E + + + L K +K++E+++C EL+ ++EA+ + +E + +Q E+
Sbjct: 1516 SDLTEQIAEGGKRIHELEKIKKQVEQEKC---ELQAALEEAEASLEHEEGKILRIQLELN 1572
Query: 467 KLKNSLEE--AKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQEL 524
++K+ ++ A++ E + + + ++ L+ R + L K+ + E+
Sbjct: 1573 QVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQST-LDAEIRSRNDAIRLKKKMEGDLNEM 1631
Query: 525 QRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDK---------------- 568
+ +L + ++ A + + + +++ + L +ALR E+ +
Sbjct: 1632 EIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEI 1691
Query: 569 -------EKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSI---KCKLEEDLQEATKLLED 618
E+ + + +AEQ++ D +R++ H + S+ K KLE D+ + +ED
Sbjct: 1692 EELRATLEQTERSRKIAEQELL--DASERVQLLHTQNTSLINTKKKLETDISQMQGEMED 1749
Query: 619 KREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLES 678
++ + ++E K + + +E KK+ T + ++++ E +LQ + E
Sbjct: 1750 ILQEARNAEEKAKKAITDAAMMAEELKKEQDT-SAHLERMKKNMEQTVKDLQLRLDEAEQ 1808
Query: 679 SLNKYNTSQ-QVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRK 737
K Q Q ++ +E+ + ES A+ K L+K + ++ + D RK
Sbjct: 1809 LALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEED---RK 1865
Query: 738 SAACQDDLTQALE-KLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRK 796
+ DL L+ K+ + + ++ K +L+ E+ EER +++ K
Sbjct: 1866 NILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNK 1925
Query: 797 LRGFHQESELEV 808
LR +E +V
Sbjct: 1926 LRVKSREVHTKV 1937
Score = 94.0 bits (232), Expect = 6e-19
Identities = 133/663 (20%), Positives = 286/663 (43%), Gaps = 91/663 (13%)
Query: 9 DREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEES 68
+ E+ + N+ +LQ + D+ + Q + Q+++ ++ A++ ++ + +E
Sbjct: 1326 EEEIKAKNALAHALQSSRHDC-DLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETD 1384
Query: 69 EVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLL 128
++ +L++ KKKL Q E H E + SL + + L+ + DL+L
Sbjct: 1385 AIQ-------RTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLML- 1436
Query: 129 HHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQE---QLALAGDKIASLERSLNLYRDKY 185
+ +++ N ++ E +E +L + + SL L ++ Y
Sbjct: 1437 --DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAY 1494
Query: 186 QSSLSNIELLECQVKMLQGELGGIMGQEPEN-KGDHS----KVRIYTSPCMIQ------- 233
+ SL +E L+ + K LQ E+ + Q E K H K ++ C +Q
Sbjct: 1495 EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAE 1554
Query: 234 ---EHQETQ---------KRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQ 281
EH+E + + SEV +K++++D+ I +L+ ++ ++E ++ L
Sbjct: 1555 ASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKR----NHIRIVESMQST--LD 1608
Query: 282 ADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSE 341
A+ S R + +++ L H + Q ++KD ++ L+
Sbjct: 1609 AEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLD---- 1664
Query: 342 QKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDK 401
D ++ + DL +E A +ER+ +LQ ++EL+ +T++ ++
Sbjct: 1665 -------DALRSQEDL----KEQLAMVERR---ANLLQAEIEELRATLEQTERSRKIAEQ 1710
Query: 402 FLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKAL 461
L + E +Q L + T + N+ K E ++ + Q ++ + A++ K A+
Sbjct: 1711 ELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAM 1770
Query: 462 QAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTI 521
AE +LK + + ER+ ++E T + LQ L LD+ + +
Sbjct: 1771 MAE--ELKKEQDTSAHLERMKK---------------NMEQTVKDLQ--LRLDEAEQLAL 1811
Query: 522 QELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQD 581
+ ++++Q L+ E E S +KR + E + LRK E KE + +
Sbjct: 1812 KGGKKQIQKLEARVRELEGEVESEQKR----NAEAVKGLRKHERRVKELTYQTEEDRKNI 1867
Query: 582 MKMNDMLDRIKHQHREQGSIKCKLEE-DLQEATKLLEDKR--EQLKKSKEHEKLMEGELE 638
+++ D++D+++ + + S K + EE + Q T L + ++ +L++++E + E ++
Sbjct: 1868 LRLQDLVDKLQAKVK---SYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVN 1924
Query: 639 ALR 641
LR
Sbjct: 1925 KLR 1927
Score = 85.1 bits (209), Expect = 3e-16
Identities = 133/757 (17%), Positives = 323/757 (42%), Gaps = 117/757 (15%)
Query: 1 MKDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKR------QRKTLQDNQLCMEEAMNSS 54
++ E E E+ L S + ++ NL +C+ + K+ ++ Q + + +
Sbjct: 1223 LEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQ 1282
Query: 55 HDKKQAQALAF----EESEV---EFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTS 107
+ Q ++ F +E E + KQ +Q+++LK++L + LQ+S
Sbjct: 1283 RGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSS 1342
Query: 108 YYSL----RQYQSILEKQTSDLVLLHHHCKLK----------EDEVILYEEEMGNHNENT 153
+ QY+ E+Q S L K E + I EE+ +
Sbjct: 1343 RHDCDLLREQYE---EEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKL 1399
Query: 154 GEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKML---QGELGGIM 210
++L A+E + K ASLE++ +++ + + ++E L Q I+
Sbjct: 1400 AQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKIL 1459
Query: 211 GQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALV 270
E + K + + + S +E + +E+++ + ++ + +L
Sbjct: 1460 A-EWKQKCEETHAELEAS------QKEARSLGTELFKIKNAYEESLDQLET--------- 1503
Query: 271 LEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVK 330
L+RE LQ + + T + +++KI K ++++K C
Sbjct: 1504 LKRENK--NLQQEISDLT---EQIAEGGKRIHELEKIKKQVEQEK---C----------- 1544
Query: 331 DLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFT 390
+L+ LE + +++++L+L+ ++ E I KD++I +L+ +
Sbjct: 1545 ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID----QLKRNHIRIV 1600
Query: 391 ETQKLTL-----KKDKFLQEKDEM---LQELEKKLTQVQNSLLKKEKELEKQQCMATELE 442
E+ + TL ++ ++ K +M L E+E +L + + Q + + +
Sbjct: 1601 ESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQ 1660
Query: 443 MTVKEAKQDKSK--------EAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAA 494
+ + +A + + E LQAE+++L+ +LE+ ++ ++A Q+ E
Sbjct: 1661 IHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQ 1720
Query: 495 LAGCHLEDTQRKLQKGLLLDKQKADT-IQELQRELQMLQKESSMAEKEQTSNRKRVEELS 553
L H ++T L+ K+K +T I ++Q E++ + +E+ AE++ +K + + +
Sbjct: 1721 LL--HTQNTS------LINTKKKLETDISQMQGEMEDILQEARNAEEKA---KKAITDAA 1769
Query: 554 LELSEALRKLENS---DKEKRQLQKTVAEQDMKMND-----------MLDRIKHQHRE-Q 598
+ E ++ + S ++ K+ +++TV + +++++ + +++ + RE +
Sbjct: 1770 MMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELE 1829
Query: 599 GSIKCKLEEDLQEATKLLEDKR--EQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSR 656
G ++ + + + + L + +R ++L E ++ L+ L + + K K+ K +
Sbjct: 1830 GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE 1889
Query: 657 KLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDL 693
+ EE++ A+ + +LE + + + ++ + L
Sbjct: 1890 EAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL 1926
Score = 78.2 bits (191), Expect = 4e-14
Identities = 95/476 (19%), Positives = 196/476 (41%), Gaps = 63/476 (13%)
Query: 505 RKLQKGLLLDKQKADTIQELQR---ELQMLQKESSMAEKEQTSNRKRVEELSLELSEALR 561
+ L K +K+ A +E Q+ EL + + E++ + K +L L++
Sbjct: 843 KPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAE 902
Query: 562 KLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKRE 621
L ++++ QL KT + + K+ ++ +R + + ++ +L + LED+
Sbjct: 903 GLADAEERCDQLIKTKIQLEAKIKEVTERAEDEE--------EINAELTAKKRKLEDECS 954
Query: 622 QLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLN 681
+LKK + +L ++E + + K K L E L+E L E + + +L+
Sbjct: 955 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1014
Query: 682 KYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAAC 741
+ + L K K L L+ +L++EK
Sbjct: 1015 DLQAEEDKVNTLTK----AKIKLEQQVDDLEGSLEQEK--------------------KL 1050
Query: 742 QDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFH 801
+ DL +A KL + K Q+S+ + +K QL +E++KK E+ L+
Sbjct: 1051 RMDLERAKRKLE---GDLKLAQESIMDIENEKQQL-------DEKLKKKEFEISNLQSKI 1100
Query: 802 QESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDD 861
++ + KK++E+ ++ + +++ + + A E+Q + E+ + E L E
Sbjct: 1101 EDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG 1160
Query: 862 KEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGE 921
+ + ++ ++ +LE+ Q + L ++ +A+L +
Sbjct: 1161 GATSAQIEMNKKREA-----EFQKMRRDLEEATLQHEATAATL---RKKHADSVAELGEQ 1212
Query: 922 KDHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRTESTQREKVCGTL 977
D+L V L++E ++K EI++ A N +KA G EK+C TL
Sbjct: 1213 IDNLQRVKQKLEKEKSEMKMEIDD---LASNVETVSKAKG-------NLEKMCRTL 1258
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 134 bits (338), Expect = 3e-31
Identities = 225/1033 (21%), Positives = 453/1033 (43%), Gaps = 155/1033 (15%)
Query: 4 EAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQAL 63
E ER + +N++L + + + L D C +K + D +L + + H
Sbjct: 927 EVTERAEDEEEINAELTAKK---RKLEDECSELKKDIDDLELTLAKVEKEKHAT------ 977
Query: 64 AFEESEVEFGSSKQCHLRQ-LQQLKKKLLVLQQELEFHTEELQTS---YYSLRQYQSILE 119
E++V+ + + L + + +L K+ LQ+ + ++LQ +L + + LE
Sbjct: 978 ---ENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLE 1034
Query: 120 KQTSDLV-LLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSL 178
+Q DL L KL+ D + G+ L LAQE + ++ L+ L
Sbjct: 1035 QQVDDLEGSLEQEKKLRMDLERAKRKLEGD--------LKLAQESIMDIENEKQQLDEKL 1086
Query: 179 NLYRDKYQSSLSNIE-------LLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCM 231
+ + S IE L+ ++K LQ + + + + +K S +
Sbjct: 1087 KKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD-L 1145
Query: 232 IQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATH 291
+E +E +RL E S Q ++ NK + + R+ LQ + + T
Sbjct: 1146 SRELEEISERLEEAGGATSAQIEM-----NKKREAEFQKMRRDLEEATLQHEATAATLRK 1200
Query: 292 RYPPSSSE---ECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMK 348
++ S +E + ++++++ + L+++K + ++ DL +E VS+ K N+ K
Sbjct: 1201 KHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID-------DLASNVETVSKAKGNLEK 1253
Query: 349 DMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTE--------TQKLTLKKD 400
LE L L+ + +R D+T + RLQ EF+ +L+ K
Sbjct: 1254 MCRTLEDQLSELKSKEEEQ-QRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQ 1312
Query: 401 KFLQEKDEMLQELEKKLTQVQNSL------------LKKEKELEKQQCMATELEMTVKEA 448
F Q+ +E+ ++LE+++ + +N+L L +E+ E+Q+ A EL+ + +A
Sbjct: 1313 AFTQQIEELKRQLEEEI-KAKNALAHALQSSRHDCDLLREQYEEEQESKA-ELQRALSKA 1370
Query: 449 KQDKSK---EAECKALQAEVQKLKNSLEEAKQQ--ERLAAQQAAQCKEEAALAGC-HLED 502
+ ++ + E A+Q + LEEAK++ +RL QAA+ EA A C LE
Sbjct: 1371 NTEVAQWRTKYETDAIQRTEE-----LEEAKKKLAQRL---QAAEEHVEAVNAKCASLEK 1422
Query: 503 TQRKLQ---KGLLLDKQKADTI----------------------QELQRELQMLQKESSM 537
T+++LQ + L+LD ++ + +E EL+ QKE+
Sbjct: 1423 TKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARS 1482
Query: 538 AEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHRE 597
E + EE +L R+ +N +E L + +AE ++++ L++IK Q +
Sbjct: 1483 LGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHE-LEKIKKQVEQ 1541
Query: 598 QGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRK 657
+ KC+L+ L+EA LE E K++ +LE L Q + D+ + E +
Sbjct: 1542 E---KCELQAALEEAEASLEH---------EEGKILRIQLE-LNQVKSEVDRKIAEKDEE 1588
Query: 658 LEEENENLRAELQCCSTQLESSLNKYNTS----QQVIQDLNK-EIALQKESLMSLQAQLD 712
+++ N ++ + L++ + N + +++ DLN+ EI L + M+ +A
Sbjct: 1589 IDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL-- 1646
Query: 713 KALQKEKHYLQTT-ITKEAY----DALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLT 767
++Y T I K+ DAL R ++ L + N + +E + L+ +L
Sbjct: 1647 ------RNYRNTQGILKDTQIHLDDAL-RSQEDLKEQLAMVERRANLLQAEIEELRATLE 1699
Query: 768 QTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQK 827
QT+ + E+E++ ER++ L+T+ L ++ E ++ ++E++ + ++
Sbjct: 1700 QTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEE 1759
Query: 828 QHQNDLKMLAAKEEQLREFQEEMAAL---KENLLEDDKEPCCLPQWSVPKDTCRLYRGND 884
+ + + A E+L++ Q+ A L K+N+ + K+ L + L G
Sbjct: 1760 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKD---LQLRLDEAEQLALKGGKK 1816
Query: 885 QI------MTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQENKK 938
QI + LE + ++ N + LR+ + + +L+ + + ++ LQ K
Sbjct: 1817 QIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDK 1876
Query: 939 LKKEIEEKKMKAE 951
L+ +++ K +AE
Sbjct: 1877 LQAKVKSYKRQAE 1889
Score = 104 bits (259), Expect = 5e-22
Identities = 148/741 (19%), Positives = 311/741 (41%), Gaps = 91/741 (12%)
Query: 272 EREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVK- 330
E EK + ++ +F + +E E+ K++ L+E+ D Q E + L
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEE--KMVTLLKEKNDLQLQVQAEAEGLADA 907
Query: 331 --------DLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRL 382
+++LEA ++ +D ++ +L + + KDI L+ L
Sbjct: 908 EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 967
Query: 383 QELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQ-----------------NSLL 425
+++ E T+ + + DE + +L K+ +Q N+L
Sbjct: 968 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLT 1027
Query: 426 KKEKELEKQQCMATELEMTVKEAKQDK-SKEAECKALQAEVQKLKNSLEEAKQQERLAAQ 484
K + +LE+Q +LE ++++ K+ + E + L+ +++ + S+ + + +++ +
Sbjct: 1028 KAKIKLEQQ---VDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDE 1084
Query: 485 QAAQCKEEAALAGCHLEDTQR---KLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKE 541
+ + + E + +ED Q +LQK + K+ I+EL+ E++ + + AEK+
Sbjct: 1085 KLKKKEFEISNLQSKIEDEQALGIQLQKKI---KELQARIEELEEEIEAERASRAKAEKQ 1141
Query: 542 QTSNRKRVEELSLELSEA----LRKLENSDKEKRQLQK--------------TVAEQDMK 583
++ + +EE+S L EA ++E + K + + QK T A K
Sbjct: 1142 RSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1201
Query: 584 MNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLED---KREQLKKSKEHEKLMEGELEAL 640
D + + Q +K KLE++ E ++D E + K+K + + M LE
Sbjct: 1202 HADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQ 1261
Query: 641 RQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQL---ESSLNKYNTSQQVIQDLNKEI 697
E K K++ + L + L+ E S QL E+ +++ + +Q +E+
Sbjct: 1262 LSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEEL 1321
Query: 698 ALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLN---- 753
Q E + + L ALQ +H + +E Y+ A +L +AL K N
Sbjct: 1322 KRQLEEEIKAKNALAHALQSSRH--DCDLLREQYEEEQESKA----ELQRALSKANTEVA 1375
Query: 754 --HVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAF 811
ET ++Q++ + +E K +L + + A EE ++ +N + L Q + EV
Sbjct: 1376 QWRTKYETDAIQRT-EELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDL 1434
Query: 812 DKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWS 871
+E + K+ +N K+LA +++ E E+ A ++ S
Sbjct: 1435 MLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEAR------------S 1482
Query: 872 VPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVH 931
+ + ++ ++ + LE ++ N+ L ++ + + IA+ L +
Sbjct: 1483 LGTELFKIKNAYEESLDQLETLKRE----NKNLQQEISDLTEQIAEGGKRIHELEKIKKQ 1538
Query: 932 LQQENKKLKKEIEEKKMKAEN 952
++QE +L+ +EE + E+
Sbjct: 1539 VEQEKCELQAALEEAEASLEH 1559
Score = 104 bits (259), Expect = 5e-22
Identities = 192/912 (21%), Positives = 386/912 (42%), Gaps = 141/912 (15%)
Query: 21 SLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQA-QALAFEESEVEFGSSKQCH 79
SL+ + K D+ + +RK D +L E M+ ++K+Q + L +E E+ S+ Q
Sbjct: 1043 SLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEI---SNLQSK 1099
Query: 80 LRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLHHHCKLKEDEV 139
+ Q L +L +EL+ EEL+ + R ++ EKQ SDL + +E
Sbjct: 1100 IEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEA 1159
Query: 140 ---ILYEEEMGNHNENTGEKLHLAQEQLALA-------------------GDKIASLER- 176
+ EM E +K+ E+ L G++I +L+R
Sbjct: 1160 GGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRV 1219
Query: 177 SLNLYRDKYQSSL------SNIEL-------LECQVKMLQGELGGIMGQEPE-----NKG 218
L ++K + + SN+E LE + L+ +L + +E E N
Sbjct: 1220 KQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDL 1279
Query: 219 DHSKVRIYTSPC----MIQEHQETQKRLSEVWQKVSQQ-DDLIQELRNKLACSNALV--- 270
+ R+ T + E + +LS Q +QQ ++L ++L ++ NAL
Sbjct: 1280 TAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHAL 1339
Query: 271 ---------------------LEREKALIKLQADFASCTATHRYPP-SSSEECEDIKKIL 308
E ++AL K + A + +EE E+ KK L
Sbjct: 1340 QSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKL 1399
Query: 309 -KHLQ------EQKDSQCLHVEE----YQNLVKDLRVELE-------AVSEQKRNIMKDM 350
+ LQ E +++C +E+ QN V+DL +++E A+ +++RN K +
Sbjct: 1400 AQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKIL 1459
Query: 351 MKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTET--QKLTLKKD-KFLQEKD 407
+ + EET A +E K+ L L +++ + E+ Q TLK++ K LQ++
Sbjct: 1460 AEWKQKC----EETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEI 1515
Query: 408 EMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQD-KSKEAECKALQAEVQ 466
L E + + + L K +K++E+++C EL+ ++EA+ + +E + +Q E+
Sbjct: 1516 SDLTEQIAEGGKRIHELEKIKKQVEQEKC---ELQAALEEAEASLEHEEGKILRIQLELN 1572
Query: 467 KLKNSLEE--AKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQEL 524
++K+ ++ A++ E + + + ++ L+ R + L K+ + E+
Sbjct: 1573 QVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQST-LDAEIRSRNDAIRLKKKMEGDLNEM 1631
Query: 525 QRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDK---------------- 568
+ +L + ++ A + + + +++ + L +ALR E+ +
Sbjct: 1632 EIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEI 1691
Query: 569 -------EKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSI---KCKLEEDLQEATKLLED 618
E+ + + +AEQ++ D +R++ H + S+ K KLE D+ + +ED
Sbjct: 1692 EELRATLEQTERSRKIAEQELL--DASERVQLLHTQNTSLINTKKKLETDISQMQGEMED 1749
Query: 619 KREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLES 678
++ + ++E K + + +E KK+ T + ++++ E +LQ + E
Sbjct: 1750 ILQEARNAEEKAKKAITDAAMMAEELKKEQDT-SAHLERMKKNMEQTVKDLQLRLDEAEQ 1808
Query: 679 SLNKYNTSQ-QVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRK 737
K Q Q ++ +E+ + ES A+ K L+K + ++ + D RK
Sbjct: 1809 LALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEED---RK 1865
Query: 738 SAACQDDLTQALE-KLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRK 796
+ DL L+ K+ + + ++ K +L+ E+ EER +++ K
Sbjct: 1866 NILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNK 1925
Query: 797 LRGFHQESELEV 808
LR +E +V
Sbjct: 1926 LRVKSREVHTKV 1937
Score = 94.0 bits (232), Expect = 6e-19
Identities = 133/663 (20%), Positives = 286/663 (43%), Gaps = 91/663 (13%)
Query: 9 DREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEES 68
+ E+ + N+ +LQ + D+ + Q + Q+++ ++ A++ ++ + +E
Sbjct: 1326 EEEIKAKNALAHALQSSRHDC-DLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETD 1384
Query: 69 EVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLL 128
++ +L++ KKKL Q E H E + SL + + L+ + DL+L
Sbjct: 1385 AIQ-------RTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLML- 1436
Query: 129 HHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQE---QLALAGDKIASLERSLNLYRDKY 185
+ +++ N ++ E +E +L + + SL L ++ Y
Sbjct: 1437 --DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAY 1494
Query: 186 QSSLSNIELLECQVKMLQGELGGIMGQEPEN-KGDHS----KVRIYTSPCMIQ------- 233
+ SL +E L+ + K LQ E+ + Q E K H K ++ C +Q
Sbjct: 1495 EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAE 1554
Query: 234 ---EHQETQ---------KRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQ 281
EH+E + + SEV +K++++D+ I +L+ ++ ++E ++ L
Sbjct: 1555 ASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKR----NHIRIVESMQST--LD 1608
Query: 282 ADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSE 341
A+ S R + +++ L H + Q ++KD ++ L+
Sbjct: 1609 AEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLD---- 1664
Query: 342 QKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDK 401
D ++ + DL +E A +ER+ +LQ ++EL+ +T++ ++
Sbjct: 1665 -------DALRSQEDL----KEQLAMVERR---ANLLQAEIEELRATLEQTERSRKIAEQ 1710
Query: 402 FLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKAL 461
L + E +Q L + T + N+ K E ++ + Q ++ + A++ K A+
Sbjct: 1711 ELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAM 1770
Query: 462 QAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTI 521
AE +LK + + ER+ ++E T + LQ L LD+ + +
Sbjct: 1771 MAE--ELKKEQDTSAHLERMKK---------------NMEQTVKDLQ--LRLDEAEQLAL 1811
Query: 522 QELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQD 581
+ ++++Q L+ E E S +KR + E + LRK E KE + +
Sbjct: 1812 KGGKKQIQKLEARVRELEGEVESEQKR----NAEAVKGLRKHERRVKELTYQTEEDRKNI 1867
Query: 582 MKMNDMLDRIKHQHREQGSIKCKLEE-DLQEATKLLEDKR--EQLKKSKEHEKLMEGELE 638
+++ D++D+++ + + S K + EE + Q T L + ++ +L++++E + E ++
Sbjct: 1868 LRLQDLVDKLQAKVK---SYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVN 1924
Query: 639 ALR 641
LR
Sbjct: 1925 KLR 1927
Score = 85.1 bits (209), Expect = 3e-16
Identities = 133/757 (17%), Positives = 323/757 (42%), Gaps = 117/757 (15%)
Query: 1 MKDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKR------QRKTLQDNQLCMEEAMNSS 54
++ E E E+ L S + ++ NL +C+ + K+ ++ Q + + +
Sbjct: 1223 LEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQ 1282
Query: 55 HDKKQAQALAF----EESEV---EFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTS 107
+ Q ++ F +E E + KQ +Q+++LK++L + LQ+S
Sbjct: 1283 RGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSS 1342
Query: 108 YYSL----RQYQSILEKQTSDLVLLHHHCKLK----------EDEVILYEEEMGNHNENT 153
+ QY+ E+Q S L K E + I EE+ +
Sbjct: 1343 RHDCDLLREQYE---EEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKL 1399
Query: 154 GEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKML---QGELGGIM 210
++L A+E + K ASLE++ +++ + + ++E L Q I+
Sbjct: 1400 AQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKIL 1459
Query: 211 GQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALV 270
E + K + + + S +E + +E+++ + ++ + +L
Sbjct: 1460 A-EWKQKCEETHAELEAS------QKEARSLGTELFKIKNAYEESLDQLET--------- 1503
Query: 271 LEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVK 330
L+RE LQ + + T + +++KI K ++++K C
Sbjct: 1504 LKRENK--NLQQEISDLT---EQIAEGGKRIHELEKIKKQVEQEK---C----------- 1544
Query: 331 DLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFT 390
+L+ LE + +++++L+L+ ++ E I KD++I +L+ +
Sbjct: 1545 ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID----QLKRNHIRIV 1600
Query: 391 ETQKLTL-----KKDKFLQEKDEM---LQELEKKLTQVQNSLLKKEKELEKQQCMATELE 442
E+ + TL ++ ++ K +M L E+E +L + + Q + + +
Sbjct: 1601 ESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQ 1660
Query: 443 MTVKEAKQDKSK--------EAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAA 494
+ + +A + + E LQAE+++L+ +LE+ ++ ++A Q+ E
Sbjct: 1661 IHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQ 1720
Query: 495 LAGCHLEDTQRKLQKGLLLDKQKADT-IQELQRELQMLQKESSMAEKEQTSNRKRVEELS 553
L H ++T L+ K+K +T I ++Q E++ + +E+ AE++ +K + + +
Sbjct: 1721 LL--HTQNTS------LINTKKKLETDISQMQGEMEDILQEARNAEEKA---KKAITDAA 1769
Query: 554 LELSEALRKLENS---DKEKRQLQKTVAEQDMKMND-----------MLDRIKHQHRE-Q 598
+ E ++ + S ++ K+ +++TV + +++++ + +++ + RE +
Sbjct: 1770 MMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELE 1829
Query: 599 GSIKCKLEEDLQEATKLLEDKR--EQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSR 656
G ++ + + + + L + +R ++L E ++ L+ L + + K K+ K +
Sbjct: 1830 GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE 1889
Query: 657 KLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDL 693
+ EE++ A+ + +LE + + + ++ + L
Sbjct: 1890 EAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL 1926
Score = 78.2 bits (191), Expect = 4e-14
Identities = 95/476 (19%), Positives = 196/476 (41%), Gaps = 63/476 (13%)
Query: 505 RKLQKGLLLDKQKADTIQELQR---ELQMLQKESSMAEKEQTSNRKRVEELSLELSEALR 561
+ L K +K+ A +E Q+ EL + + E++ + K +L L++
Sbjct: 843 KPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAE 902
Query: 562 KLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKRE 621
L ++++ QL KT + + K+ ++ +R + + ++ +L + LED+
Sbjct: 903 GLADAEERCDQLIKTKIQLEAKIKEVTERAEDEE--------EINAELTAKKRKLEDECS 954
Query: 622 QLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLN 681
+LKK + +L ++E + + K K L E L+E L E + + +L+
Sbjct: 955 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1014
Query: 682 KYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAAC 741
+ + L K K L L+ +L++EK
Sbjct: 1015 DLQAEEDKVNTLTK----AKIKLEQQVDDLEGSLEQEK--------------------KL 1050
Query: 742 QDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFH 801
+ DL +A KL + K Q+S+ + +K QL +E++KK E+ L+
Sbjct: 1051 RMDLERAKRKLE---GDLKLAQESIMDIENEKQQL-------DEKLKKKEFEISNLQSKI 1100
Query: 802 QESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDD 861
++ + KK++E+ ++ + +++ + + A E+Q + E+ + E L E
Sbjct: 1101 EDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG 1160
Query: 862 KEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGE 921
+ + ++ ++ +LE+ Q + L ++ +A+L +
Sbjct: 1161 GATSAQIEMNKKREA-----EFQKMRRDLEEATLQHEATAATL---RKKHADSVAELGEQ 1212
Query: 922 KDHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRTESTQREKVCGTL 977
D+L V L++E ++K EI++ A N +KA G EK+C TL
Sbjct: 1213 IDNLQRVKQKLEKEKSEMKMEIDD---LASNVETVSKAKG-------NLEKMCRTL 1258
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 134 bits (337), Expect = 4e-31
Identities = 216/929 (23%), Positives = 388/929 (41%), Gaps = 115/929 (12%)
Query: 82 QLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQ---SILEKQTSDLVLLHHHCKLKEDE 138
+L K K+ L+QELE TE+L L Q + L+++ +L+ ++ DE
Sbjct: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDE 311
Query: 139 VILYEEE------MGNHNENTGEKLHLAQEQLA----LAGDKIASLERSLNLYRDKYQSS 188
+ E+ + + E+LH + A L D LE L +
Sbjct: 312 LDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTR 371
Query: 189 LSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQK-----RLS 243
+ +L E + + LQ + + E E D K+ M E + Q L
Sbjct: 372 ARSDKLHELEKENLQLK-AKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLG 430
Query: 244 EVWQKVSQQDDLIQELRNKLACS-NALVLEREKALIKLQADFASCTATHRYPPSSSEECE 302
+++S+ +L + + L N L R L+KL+ + S T T ++ + E
Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELTSSR---LLKLEMENQSLTKTVEELRTTVDSVE 487
Query: 303 -DIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLR 361
+ KILK ++++ VE +N + + L+ +++MK+ +LE + LR
Sbjct: 488 GNASKILK-MEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLR 546
Query: 362 EETSAHI-----ERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKK 416
E + I E + + T+ R Q Q+ K K++K L E ++E K
Sbjct: 547 ENSERQIKILEQENEHLNQTVSSLR-QRSQISAEARVKDIEKENKILHES---IKETSSK 602
Query: 417 LTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLE--E 474
L++++ + +KELE + E E E E + LQ ++ LK + E E
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELHH---LEKENELLQKKITNLKITCEKIE 659
Query: 475 AKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKE 534
A +QE LE RKL+K L D+ + L +L+ L+KE
Sbjct: 660 ALEQEN-----------------SELERENRKLKKTL-------DSFKNLTFQLESLEKE 695
Query: 535 SSMAEKEQTSNRKRVEELSL-ELSEALRKLENSD--KEKRQLQK--TVAEQDMKMNDMLD 589
+S ++E R+ VE L + A +LEN + EK QL+K + + K + L+
Sbjct: 696 NSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLE 755
Query: 590 -----------RIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELE 638
R++ +LE +LQ+ LE + + L+K+ E K+ LE
Sbjct: 756 VSYQGLDIENQRLQKTLENSNKKIQQLESELQD----LEMENQTLQKNLEELKISSKRLE 811
Query: 639 ALRQEFKKKDKT---LKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNK 695
L +E K ++ L+++ ++LE+EN+ LR + + T LE + K ++ + L+K
Sbjct: 812 QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871
Query: 696 EIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHV 755
EI + KES + L K L+KE L T + + ++DL K +
Sbjct: 872 EIGIYKESCVRL-----KELEKENKELVKRATIDI-----KTLVTLREDLVSEKLKTQQM 921
Query: 756 TSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRK-LRGFHQESELEVHAFDKK 814
++ + L L + K +L + + ++R K L ++L L+ + E ++ A + +
Sbjct: 922 NNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEAR 981
Query: 815 LEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAAL--------KENLLEDDKEPCC 866
LEE + + +Q + +LK + E L++ Q+E + ++N E + +
Sbjct: 982 LEEST----NYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETT 1037
Query: 867 LPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLH 926
V + R N + +Q K Q E N L+ Q I L + L
Sbjct: 1038 RELLKVKDRLIEVERNNATLQAE-KQALKTQLKQLETQNNNLQAQ---ILALQRQTVSLQ 1093
Query: 927 SVMVHLQQENKKLKKEIEEKKMKAENTRL 955
LQ +N KL ++E + +++T L
Sbjct: 1094 EQNTTLQTQNAKL--QVENSTLNSQSTSL 1120
Score = 125 bits (313), Expect = 3e-28
Identities = 226/1020 (22%), Positives = 414/1020 (40%), Gaps = 121/1020 (11%)
Query: 3 DEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQA 62
D+ E ++E L +KL ++++ D+ +++ + L + + +E A S D+
Sbjct: 375 DKLHELEKENLQLKAKLHDMEME----RDMDRKKIEELMEENMTLEMAQKQSMDESLHLG 430
Query: 63 LAFEE----SEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHT---EELQTSYYSLRQYQ 115
E+ SE+ K + +LL L+ E + T EEL+T+ S+
Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNA 490
Query: 116 SILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIA-SL 174
S + K + L ++ E+E++ ++ + N +N + L + QL + + +
Sbjct: 491 SKILKMEKENQRLSKKVEILENEIVQEKQSLQNC-QNLSKDLMKEKAQLEKTIETLRENS 549
Query: 175 ERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQE 234
ER + + + + + L Q + E + E ENK H ++ +S E
Sbjct: 550 ERQIKILEQENEHLNQTVSSLR-QRSQISAE-ARVKDIEKENKILHESIKETSSKLSKIE 607
Query: 235 HQETQ--KRLSEVWQKVSQQDDLIQELRN---------------KLACSNALVLEREKA- 276
++ Q K L +K + ++L EL + K+ C LE+E +
Sbjct: 608 FEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSE 667
Query: 277 -------LIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLV 329
L K F + T + + ++ L+ E + + + Q
Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
Query: 330 KDLRVELEAVS---EQKRNIMKDMMKLELDLHGL---REETSAHIERKDKDITILQCRLQ 383
K+L E E + E + K +LE+ GL + +E +K I L+ LQ
Sbjct: 728 KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQ 787
Query: 384 ELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQC---MATE 440
+L++E QK L++ K ++ E L++ K L Q + L K +K+LEK+ E
Sbjct: 788 DLEMENQTLQK-NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE 846
Query: 441 LEMTVKEAKQDK--SKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGC 498
++ T E K + E E K L E+ K S K+ E+ + + + A +
Sbjct: 847 IKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEK----ENKELVKRATIDIK 902
Query: 499 HLEDTQRKLQKGLLLDKQKADTIQELQRELQM--LQKESSMAEKEQTSNRKRVEELSLE- 555
L + L L +Q + +++L EL+ L KE + +++ T +R ++ E LE
Sbjct: 903 TLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLES 962
Query: 556 ---------------LSEALRKLENSDKEKRQLQKTVAE--QDMKMNDMLDRIKHQHREQ 598
L L + N +++ RQ KTV + + +K +R+
Sbjct: 963 TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPI 1022
Query: 599 GSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKL 658
K E + QE T+ L +++L + + + ++ E +AL+ + K+ L
Sbjct: 1023 SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQ-----------L 1071
Query: 659 EEENENLRAELQCCSTQLESSLNKYNTSQQV----IQDLNKEIALQKESLMSLQAQL--- 711
E +N NL+A++ Q SL + NT+ Q +Q N + Q SLM+ AQL
Sbjct: 1072 ETQNNNLQAQILALQRQ-TVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQ 1130
Query: 712 DKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLN-HVTSETKSLQQSLTQTQ 770
+L+ E ++ KE D S + +D + LE L+ SE +SL +
Sbjct: 1131 QSSLENENE----SVIKEREDLKSLYDSLIKDH--EKLELLHERQASEYESLISKHGTLK 1184
Query: 771 EKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQ 830
LE E E+R +L Q+ +LE +K L+ ++L K H+
Sbjct: 1185 SAHKNLEVEHRDLEDRYNQL---------LKQKGQLE--DLEKMLKVEQEKMLLENKNHE 1233
Query: 831 N---DLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIM 887
+ K L + ++L ++ E L D K L S + T RL +
Sbjct: 1234 TVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQT-RL----EAEF 1288
Query: 888 TNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKK 947
+ L++ +Q + + KL NQ + L E HL + L +N+ L ++ E K
Sbjct: 1289 SKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESK 1348
Score = 117 bits (294), Expect = 4e-26
Identities = 172/759 (22%), Positives = 336/759 (44%), Gaps = 107/759 (14%)
Query: 232 IQEHQETQKRLSEV-WQKVSQ--QDDLIQELRNKLACSNALVLEREK---ALIKLQADFA 285
IQE Q+ + ++ W +V+ Q+D+ L+N L+ ER++ +I+L +
Sbjct: 160 IQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEER- 218
Query: 286 SCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRN 345
H P +SS E + + + + + ++ LR ELE +EQ +
Sbjct: 219 --DGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLD 276
Query: 346 IMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQE 405
+++ ++E++L L++E + ++ + + + L L+ + KL + ++
Sbjct: 277 CKQELEQMEIELKRLQQE-NMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRY--- 332
Query: 406 KDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEV 465
E L ++E +V+ + LE + + +LE T A+ DK E E + LQ
Sbjct: 333 -KERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGT--RARSDKLHELEKENLQ--- 386
Query: 466 QKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQ 525
LK L + + + + ++ + EE LE Q KQ D L
Sbjct: 387 --LKAKLHDMEMERDMDRKKIEELMEE----NMTLEMAQ----------KQSMDESLHLG 430
Query: 526 RELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMN 585
EL+ + + S ++E Q S V EL+ S L KLE E + L KTV E +
Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELT---SSRLLKLE---MENQSLTKTVEE----LR 480
Query: 586 DMLDRIKHQHREQGSIKCKLEEDLQEATK---LLEDKREQLKKSKEHEKLMEGELEALRQ 642
+D ++ S K+E++ Q +K +LE++ Q K+S ++ + + +L +
Sbjct: 481 TTVDSVEGN----ASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
Query: 643 EFKKKDKTLKENSRK----LEEENENLRAELQCCSTQLESSLNKYN--TSQQVIQDLNKE 696
+ +K +TL+ENS + LE+ENE+L Q SSL + + +++ ++D+ KE
Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHLN--------QTVSSLRQRSQISAEARVKDIEKE 588
Query: 697 IALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVT 756
+ ES+ ++L K ++ EK ++ + E Y ++ +++L +H+
Sbjct: 589 NKILHESIKETSSKLSK-IEFEKRQIKKEL--EHYKEKGERAEELENEL-------HHLE 638
Query: 757 SETKSLQQSLTQ---TQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDK 813
E + LQ+ +T T EK LE+E +++ N +L+K + ++ + +K
Sbjct: 639 KENELLQKKITNLKITCEKIEALEQE----NSELERENRKLKKTLDSFKNLTFQLESLEK 694
Query: 814 KLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVP 873
+ ++ + L+ ++ ++ LK + K QL+ +E+ + KE L
Sbjct: 695 ENSQLDEENLELRRNVES-LKCASMKMAQLQLENKELESEKEQL---------------- 737
Query: 874 KDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQ 933
K L + + + LE + + N++L L K I +L E + L+
Sbjct: 738 KKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESE-------LQDLE 790
Query: 934 QENKKLKKEIEEKKMKAENTRLCTKALGPSRTESTQREK 972
EN+ L+K +EE K+ ++ K E++Q EK
Sbjct: 791 MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEK 829
Score = 94.4 bits (233), Expect = 5e-19
Identities = 187/786 (23%), Positives = 324/786 (41%), Gaps = 122/786 (15%)
Query: 3 DEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDN------------------- 43
+ A E + E+ L + LQ I NL C++ Q+N
Sbjct: 625 ERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKN 684
Query: 44 ---QLCMEEAMNSSHDKKQAQALAFEESEVEFGSSKQCHLR--------QLQQLKKKLLV 92
QL E NS D++ + ES ++ S K L+ + +QLKK L +
Sbjct: 685 LTFQLESLEKENSQLDEENLELRRNVES-LKCASMKMAQLQLENKELESEKEQLKKGLEL 743
Query: 93 LQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHN-E 151
L+ + TE L+ SY L +E Q L + + K+++ E L + EM N +
Sbjct: 744 LKASFK-KTERLEVSYQGLD-----IENQRLQKTLENSNKKIQQLESELQDLEMENQTLQ 797
Query: 152 NTGEKLHLAQEQLALAGDKIASLERSLN-LYRDKYQSSLSNIEL---LECQVKMLQGELG 207
E+L ++ ++L + SLE+ + L +DK Q N L E + L+
Sbjct: 798 KNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNV 857
Query: 208 GIMGQEPENKGDHSKVRIYTSPC-----MIQEHQETQKRLS-EVWQKVSQQDDLIQELRN 261
I E ENK ++ IY C + +E++E KR + ++ V+ ++DL+ E
Sbjct: 858 KIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLK 917
Query: 262 KLACSN---ALVLEREK-ALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDS 317
+N L E EK L K + + RY S+ +KK L+ +E+ +
Sbjct: 918 TQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAA 977
Query: 318 QCLHVEEYQNLVKDLRVELEAVSE-----QKRNIMKDMMKLELDLHG--------LREET 364
+EE N + LR EL+ V + ++R + M++ + G +E T
Sbjct: 978 LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETT 1037
Query: 365 SAHIERKDKDITI------LQCRLQEL--QLEFTETQKLTL--------KKDKFLQEKDE 408
++ KD+ I + LQ Q L QL+ ETQ L ++ LQE++
Sbjct: 1038 RELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNT 1097
Query: 409 MLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKL 468
LQ KL QV+NS L + M ++ ++++ + E+ K + +++ L
Sbjct: 1098 TLQTQNAKL-QVENSTLNSQST----SLMNQNAQLLIQQSSLENENESVIKERE-DLKSL 1151
Query: 469 KNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQREL 528
+SL K E+L Q E +L H T + K L ++ + + R
Sbjct: 1152 YDSL--IKDHEKLELLHERQASEYESLISKH--GTLKSAHKNLEVEHRDLE-----DRYN 1202
Query: 529 QMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDML 588
Q+L+++ + + E+ L++ + LEN + E TVA + K+
Sbjct: 1203 QLLKQKGQLEDLEKM----------LKVEQEKMLLENKNHE------TVAAEYKKLCGEN 1246
Query: 589 DRIKHQHREQGSIKCKLEEDLQEATKLLED-KREQLKKSKEHEKLMEG--ELEALRQEFK 645
DR+ H + + L+ D + LL + K EQ + E KL E +L+ +
Sbjct: 1247 DRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLN 1306
Query: 646 KKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNK-------YNTSQQVIQDLNKEIA 698
+ + L + LEEEN +L ++Q Q + L + ++ Q+ D E+
Sbjct: 1307 NQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELR 1366
Query: 699 LQKESL 704
QKE L
Sbjct: 1367 RQKEKL 1372
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 134 bits (336), Expect = 6e-31
Identities = 220/1046 (21%), Positives = 436/1046 (41%), Gaps = 140/1046 (13%)
Query: 16 NSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEESEVEFGSS 75
+++ + + +K L ++ + +K +N E+ N +K Q Q + +
Sbjct: 662 STEAIEAKAALKQLQEIFENYKKEKAEN----EKIQNEQLEKLQEQVTDLRSQNTKIST- 716
Query: 76 KQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLHHHCKLK 135
QL K+ +LQ +E + E+ + + ++ + +KQ + + +
Sbjct: 717 ------QLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGA 770
Query: 136 EDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELL 195
+++ + E N + E L L++ +L+ + + + +R NL Q+ +E
Sbjct: 771 NEKLAVAEVRAENLKKEK-EMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERS 829
Query: 196 ECQVKM-LQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQK---RLSEVWQKVSQ 251
E + K L ++ ++ E++ H K ++ + Q H T+ +L + +++
Sbjct: 830 ETETKQRLSSQI-----EKLEHEISHLKKKLENE--VEQRHTLTRNLDVQLLDTKRQLDT 882
Query: 252 QDDLIQELRNKLACSNA----LVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKI 307
+ +L L K NA L++ + +++Q S T + PS+ E+ +D+
Sbjct: 883 ETNL--HLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQ 940
Query: 308 LKHLQEQKD-------SQCLHVEEYQNLV------------------KDLRVELEAVSEQ 342
L+ +EQ + + +VE+YQ +V K++ V L+ +E
Sbjct: 941 LRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEF 1000
Query: 343 KRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKF 402
+ + K +M++E + L+++ IE ++ ++ L+ L +Q E E +
Sbjct: 1001 QTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSN 1060
Query: 403 LQEKDEMLQELEKKLTQVQN--------------SLLKKEKELEKQQCMATELEMTVKEA 448
Q+ QE K + QN +L ++++ K + LE T ++A
Sbjct: 1061 EQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKA 1120
Query: 449 KQDKSKEAECKA--------LQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHL 500
+ S+ ECKA L+ EV K E+ ++Q RL Q + ++ +
Sbjct: 1121 E---SQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASV--K 1175
Query: 501 EDTQRKLQKGLLLDKQKADTIQEL----QRELQMLQKESSMAEKEQTSNRKRVEELSLEL 556
E Q L L + + + I E+ +RE ++ + +A+ E R+RVE L EL
Sbjct: 1176 EGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLEREL 1235
Query: 557 SEALRKLENSDKEKRQLQ-KTVAEQD--MKMNDMLDRIKHQHREQGSIKCKLEEDLQEAT 613
E L N+++EK Q+ KT+A+ + MK + ++ + ++ K +LE+DLQ+
Sbjct: 1236 QELQDSL-NAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQ-- 1292
Query: 614 KLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCS 673
++ K +L+ + EL + + K L+E+ ++ + N++L ++ +
Sbjct: 1293 --MQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPD 1350
Query: 674 TQ-LESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYD 732
T+ L++ + IQ L +EI K + A+ + +L ++ +Q+ KE +
Sbjct: 1351 TEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEI----ARSNASLTNNQNLIQSL--KEDLN 1404
Query: 733 ALSRKSAACQDDLTQAL----EKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMK 788
+ + Q DL + EK+ +T K ++ TQ +E KAQ + K
Sbjct: 1405 KVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQD----------K 1454
Query: 789 KLNTELRKLRGFHQESEL---EVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLRE 845
+ T + G HQE + E+ + L + + + Q +N K L+ KE + R
Sbjct: 1455 VMETSAQS-SGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARN 1513
Query: 846 FQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLG 905
QE+ L+ L RL + T EQ +Q EK
Sbjct: 1514 LQEQTVQLQSEL-------------------SRLRQDLQDRTTQEEQLRQQITEKEEKTR 1554
Query: 906 NQLREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGP-SR 964
+ IA L+G KD L L+Q N L ++ +E ++ T L ++ G SR
Sbjct: 1555 KAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRI--TALKSQYEGRISR 1612
Query: 965 TESTQREKVCGTLGWKGLPQDMGQRM 990
E RE L + PQ+ ++
Sbjct: 1613 LERELREHQERHLEQRDEPQEPSNKV 1638
Score = 108 bits (270), Expect = 3e-23
Identities = 184/869 (21%), Positives = 374/869 (43%), Gaps = 125/869 (14%)
Query: 1 MKDEAGERDREVSSLNSKLLSL--QLDIK-NLHDVCKRQRKTLQDNQLCMEEAMNSSHDK 57
+++E +R +L+ +LL QLD + NLH K K Q +++ +++ +
Sbjct: 855 LENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQ 914
Query: 58 KQAQALAFEESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSI 117
+Q S G + + + L +L ++++ E L+TS ++ QYQ++
Sbjct: 915 VASQ------SSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAM 968
Query: 118 L---------EKQTSDLVLLHHHCKLKED---------EVILYEEEMGNHNENTGEKLHL 159
+ EKQ ++ V + +LKE +++ E+E ++ +
Sbjct: 969 VTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIES 1028
Query: 160 AQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELL--ECQVKMLQGELGGIMGQEPENK 217
++QL+ ++S++ + + ++LSN + +CQ + + E +NK
Sbjct: 1029 MEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK-------IAVEAQNK 1081
Query: 218 GDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKAL 277
+ + +Q +E +++ V Q + ++ Q+ ++L A ERE+ L
Sbjct: 1082 YERELMLHAADVEALQAAKEQVSKMASVRQHL---EETTQKAESQLLECKASWEERERML 1138
Query: 278 IKLQADFASCTATHRYPPSSSEECEDIKKI--LKHLQEQKDSQCLHVEEYQNLVKDLRVE 335
+ + + C CED++K L H Q +K S + + + L V
Sbjct: 1139 ---KDEVSKCVC----------RCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
Query: 336 LEAVSEQKRNIMKDM--MKLELDLHGLREETSAHIE--RKDKDITILQCRLQELQLEFTE 391
L + + I++ + ++ E ++ R E A +E R + + +L+ LQELQ
Sbjct: 1186 LSEEGKSQEQILEILRFIRREKEIAETRFEV-AQVESLRYRQRVELLERELQELQDSLNA 1244
Query: 392 TQKLTLKKDKFLQEKDEMLQELEK-KLTQVQNSLLKKEKE-----LEKQQCMATELEMTV 445
++ K + + +E++++ E + N +L++EKE L++ Q +LE+ +
Sbjct: 1245 EREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDI 1304
Query: 446 KEAKQDKSKEAECKA-LQAEVQKLKNSLEEAK-QQERLAAQQAAQCKEEAALAGCHLEDT 503
++ ++ +E LQAE + L+ ++ K + + L +QQ +D
Sbjct: 1305 LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQ---------------KDP 1349
Query: 504 QRKLQKGLLLDKQ-KADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRK 562
+ + LL +K+ IQ+L E+ L+ E + + T+N+ ++ L +L++
Sbjct: 1350 DTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRT- 1408
Query: 563 LENSDKEKRQLQKTVAEQDMKMNDMLDRIKH--QHREQGS-IKCKLEEDLQEATKLLEDK 619
EK +QK + D K+ D+ +++K Q ++ G K + EE + K++E
Sbjct: 1409 ------EKETIQKDL---DAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETS 1459
Query: 620 REQLKKSKE-HEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLES 678
+ +E H + E QE K+ + S+ LE + ENL+ L E
Sbjct: 1460 AQSSGDHQEQHVSVQE------MQELKETLNQAETKSKSLESQVENLQKTLS------EK 1507
Query: 679 SLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKS 738
N +Q +Q L E++ ++ L D+ Q+E+ Q T +E +RK+
Sbjct: 1508 ETEARNLQEQTVQ-LQSELSRLRQDLQ------DRTTQEEQLRQQITEKEEK----TRKA 1556
Query: 739 -AACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIA----YEERMKKLNTE 793
A + + + +T E + L+Q ++K +L+ I A YE R+ +L E
Sbjct: 1557 IVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERE 1616
Query: 794 LRKLRGFHQESELEVHAFDKKLEEMSCQV 822
LR+ + H E E K+ E Q+
Sbjct: 1617 LREHQERHLEQRDEPQEPSNKVPEQQRQI 1645
Score = 102 bits (255), Expect = 1e-21
Identities = 199/1058 (18%), Positives = 413/1058 (39%), Gaps = 156/1058 (14%)
Query: 4 EAGERD--REVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQ 61
EA +RD R L+ +L L D+K L++ K T + QL ++E S K +
Sbjct: 121 EAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYRE 180
Query: 62 ALAFEESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQ 121
+E E+ + + +L+ +LL L +E EL+ + + ++ S LE+Q
Sbjct: 181 KRLEQEKELLHSQNTWLNT-ELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQ 239
Query: 122 TSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLH---------------------LA 160
+ L + H + ++++ +E + EK H
Sbjct: 240 MNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAK 299
Query: 161 QEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDH 220
+L A +++ L + Q L +E + Q++ E G + +E EN D
Sbjct: 300 SNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDL 359
Query: 221 SKVRIYTSPCMIQEHQETQK--------------RLSEVWQKVSQQDD--LIQELRNKLA 264
+ +E +L+E++ + D L+++L NK
Sbjct: 360 LSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRI 419
Query: 265 CS--NALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQE--------- 313
+ +V E E L+ + S S + E K ++ LQE
Sbjct: 420 NKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQS 479
Query: 314 ---QKDSQCLHVEEYQNLVKDLRVELEAVSEQKRN-IMKDMMKLELDLHGLREETSAHI- 368
++D++ + + + ++L + +RV L + E + N +++D D+ E S H+
Sbjct: 480 SVLERDNRRMEI-QVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLV 538
Query: 369 --------------------------ERKDKDITILQCRLQELQLEFTETQKLTLKK--- 399
ER++++ T + +L+LE T+ L+K
Sbjct: 539 SYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQ 598
Query: 400 ------DKFLQEKDEMLQELEKKLTQV----------QNSLLKKEKELEKQQCMATELEM 443
D ++++D M + L + T V SL K Q ++T +
Sbjct: 599 HQMQLVDSIVRQRD-MYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPV 657
Query: 444 TVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDT 503
V E+ + +A K LQ + +N +E + E++ +Q + +E+
Sbjct: 658 PVIESTEAIEAKAALKQLQ---EIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKI 714
Query: 504 QRKLQKGLLLDKQKADTIQELQRELQML----QKESSMAEKEQTSNRKRVEEL---SLEL 556
+L + D ++ +RE+ L QK ++ +K++ ++L + +L
Sbjct: 715 STQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKL 774
Query: 557 SEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLL 616
+ A + EN KEK L+ + +++++ + + + R Q L +LQ +L
Sbjct: 775 AVAEVRAENLKKEKEMLKLS----EVRLSQQRESLLAEQRGQN----LLLTNLQTIQGIL 826
Query: 617 EDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQL 676
E + E ++ + ++E L E K L+ + NL +L QL
Sbjct: 827 E------RSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQL 880
Query: 677 ESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSR 736
++ N + +++++++ KEIA K+ L +++ Q+ + Q + KE D L
Sbjct: 881 DTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPS-NKEDVDDLVS 939
Query: 737 KSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRK 796
+ ++ + E+L TS + Q +T +E L +E EE K + L++
Sbjct: 940 QLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEE---SLNKEKQVTEEVRKNIEVRLKE 996
Query: 797 LRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKEN 856
F + E ++ +K+ +E+ + + + + E+QL E ++ +++++
Sbjct: 997 SAEFQTQLEKKLMEVEKEKQEL----------QDDKRRAIESMEQQLSELKKTLSSVQNE 1046
Query: 857 LLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIA 916
+ E ++ + + L Q + ++ AK A K +L +
Sbjct: 1047 VQE-----------ALQRASTAL-SNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVE 1094
Query: 917 KLSGEKDH---LHSVMVHLQQENKKLKKEIEEKKMKAE 951
L K+ + SV HL++ +K + ++ E K E
Sbjct: 1095 ALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWE 1132
Score = 87.0 bits (214), Expect = 8e-17
Identities = 129/623 (20%), Positives = 272/623 (43%), Gaps = 69/623 (11%)
Query: 242 LSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATH-RYPPSSSEE 300
++ V Q+V ++ +L NKL S LE K L Q++ H ++ S ++
Sbjct: 1 MAAVLQQVLERTEL-----NKLPKSVQNKLE--KFLADQQSEIDGLKGRHEKFKVESEQQ 53
Query: 301 CEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGL 360
+I+K L H QE+ ++ + + ++ L +L+A++E+ + ++ + +
Sbjct: 54 YFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKE-LEIAQDRNIAIQSQ 112
Query: 361 REETSAHIERKDKDITILQCRL-QELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQ 419
T +E + +D+ RL QEL+ + ++L K L+E + EL+ KL +
Sbjct: 113 FTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEK----LKESNTTKGELQLKLDE 168
Query: 420 VQN---SLLKKEKELEKQQCMATELEMTVKEAKQDKSKE--AECKALQAEVQKLKNSLEE 474
+Q S+ +EK LE+++ + + + K+ E A + E+ +LK +LE
Sbjct: 169 LQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLEN 228
Query: 475 AKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKE 534
K++ +Q K H+ED KL++ +Q+A ++ EL K
Sbjct: 229 KKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEA---KEQQASMEEKFHNELNAHIKL 285
Query: 535 SSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQ 594
S++ + + E S EL+ A+ +L KE + K + + +++ D+++ +
Sbjct: 286 SNLYKSAADDS----EAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKE 341
Query: 595 HREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKEN 654
E+ +LE++L+ A LL + ++ L E EL A+ K +K
Sbjct: 342 MLEKIG---RLEKELENANDLLSATK------RKGAILSEEELAAMSPTAAAVAKIVKPG 392
Query: 655 SRKLEEENENLRAELQCCSTQLESS-LNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDK 713
+ E N + + Q +LE+ +NKY ++++++ + + K
Sbjct: 393 MKLTELYNAYVETQDQLLLEKLENKRINKY--LDEIVKEVEAKAPILKRQ---------- 440
Query: 714 ALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKK 773
+E Y+ + A+ L QA++++ + +T + + +
Sbjct: 441 --------------REEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDN 486
Query: 774 AQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFD--KKLEEMSCQVLQWQK---- 827
++E ++ ++++ L EL + RG H + EV + D E +S ++ ++
Sbjct: 487 RRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEEL 546
Query: 828 QHQNDLKMLAAKE-EQLREFQEE 849
Q QN ++A +E + RE +E+
Sbjct: 547 QQQNQRLLVALRELGETREREEQ 569
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 133 bits (335), Expect = 7e-31
Identities = 198/986 (20%), Positives = 428/986 (43%), Gaps = 127/986 (12%)
Query: 11 EVSSLNSKLLSLQLDIKNLHDVC---KRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEE 67
E L L + + + K L + C K + + L++ ++E N+ K++ + +A +
Sbjct: 387 EEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNG--KEKLRIMAVKN 444
Query: 68 SEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSI---LEKQTSD 124
SEV + QL + ++ +L L+ ELE E L+ + + + + + + Q
Sbjct: 445 SEV---------MAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNER 495
Query: 125 LVLLHHHCKLKEDEVILYEE---EMGNHNENTGEKLHLAQEQLALAGDK----IASLERS 177
L L + E+ E+ ++ E G K +L++ Q++ +K I E +
Sbjct: 496 LDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEAN 555
Query: 178 -LNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQ 236
L + + + ++ E+ + + +L + +++ + T P + HQ
Sbjct: 556 KLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQ 615
Query: 237 -------ETQKRLSEVWQKVSQQDDL-IQELRNKLACSNALVLEREKALIKLQADFASCT 288
+ Q +++ ++K Q+ I+ELR KL + +E E + +K+
Sbjct: 616 VAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKL-----IQIEAENSDLKVNM----AH 666
Query: 289 ATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMK 348
T ++ E E K L+ + +C + + +++ V +++ + + +
Sbjct: 667 RTSQFQLIQEELLEKASNSSK-LESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQ 725
Query: 349 DMMKLELDLHGLREETSAHIER------KDKDITILQCRLQELQLEFTETQKLTLKKDKF 402
++M+ + L + E+ K K I + Q + E Q+E E Q
Sbjct: 726 ELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQ--------- 776
Query: 403 LQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQ 462
L++KD+ +E EK ++ +Q ++ K+ LE + TE + +K K++ K+ KALQ
Sbjct: 777 LEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMK--KENMKKDEALKALQ 834
Query: 463 AEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQ 522
+V + E K ++ +A + CKEE L LE + K +K L K+K++ +
Sbjct: 835 NQVSE-----ETIKVRQLDSALEI--CKEELVLHLNQLEGNKEKFEKQL---KKKSEEVY 884
Query: 523 ELQRELQM------------------LQKESSMAEKEQTSNRKRVEELSLELSEALRKLE 564
LQ+EL++ LQ++ M ++E N + +E+ +L + + KLE
Sbjct: 885 CLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGE-LEDTQTKLEKQVSKLE 943
Query: 565 NSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLK 624
+++R+ + AE+ KM + + H+ + +L ++ ++ +E+L
Sbjct: 944 QELQKQRE---SSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELS 1000
Query: 625 KSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRA--ELQ-CCSTQLESSLN 681
K ++ ++ + E + D L + +LE++ ++ +LQ T+L +L
Sbjct: 1001 KMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQ 1060
Query: 682 KYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAAC 741
K + +Q+ + E+ K +L LQ +L LQK + L+ E Y + +A
Sbjct: 1061 KREVLETELQNAHGEL---KSTLRQLQ-ELRDVLQKAQLSLE-----EKYTTIKDLTAEL 1111
Query: 742 QDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFH 801
++ + +K + ++L++ + +++ AQ+ + E ++ ++ KL G
Sbjct: 1112 RECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTL 1171
Query: 802 QESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDD 861
++SELE+ +K++E ++ ++ QN + L KE + + ++E++ LK+ +
Sbjct: 1172 EKSELELKECNKQIESLNDKL-------QNAKEQLREKEFIMLQNEQEISQLKKEI---- 1220
Query: 862 KEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGE 921
+ T + + + +M EQ+ Q LG +LR + + E
Sbjct: 1221 ------------ERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTE 1268
Query: 922 KDHLHSVMVHLQQENKKLKKEIEEKK 947
V Q+E ++L E+E+ K
Sbjct: 1269 LAEARHQQVQAQREIERLSSELEDMK 1294
Score = 123 bits (309), Expect = 8e-28
Identities = 231/1078 (21%), Positives = 454/1078 (42%), Gaps = 177/1078 (16%)
Query: 1 MKDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQA 60
M + A ++ V L ++++L+ ++ V + L+ +Q + E S + K+
Sbjct: 275 MLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEE 334
Query: 61 ----QALAFEESEVEFGSSKQCH--LRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQY 114
+ E+++ + +Q + L ++L K ++++ E++Q L +
Sbjct: 335 CIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERN 394
Query: 115 QSILEKQTSDLVLLHHHCKLKEDEVILYEE---EMGNHNENTGEKLHL-------AQEQL 164
+ EK+ L C L + E+ + +E ++ N N EKL + QL
Sbjct: 395 LTNCEKENKRL---QERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQL 451
Query: 165 ALAGDKIASLERSLN----LYRDKYQSSLSNIELLECQVKML-QGELGGIMGQEPENKGD 219
+ I LE L + RDK+ N EL +V++ Q E + QE E+
Sbjct: 452 TESRQSILKLESELENKDEILRDKFSLMNENREL---KVRVAAQNERLDLCQQEIESSRV 508
Query: 220 H--SKVRIYTSPCMIQEHQETQKRLSEV-WQKVSQQDD-----------LIQELRNKLAC 265
S +I + + +E + LS+ S ++D +I ELR KLA
Sbjct: 509 ELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAI 568
Query: 266 SNALVLEREKALI--KLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHV- 322
A + + L +L +C + SS E E +K + E Q H
Sbjct: 569 KEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTM 628
Query: 323 -----EEYQNLV---KDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKD 374
+E Q LV ++LR +L + + ++ +M ++EE K
Sbjct: 629 NKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSK- 687
Query: 375 ITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQ 434
L+ E T+ L +K L+EK + K +++ L++K +++
Sbjct: 688 ----------LESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSL 737
Query: 435 Q----------CMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAA- 483
+ C+A E + +Q K E + + L+A+++K ++ K+QE+ +
Sbjct: 738 ETNINTEHEKICLAFEKAKKI-HLEQHKEMEKQIERLEAQLEKKD---QQFKEQEKTMSM 793
Query: 484 -QQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQ 542
QQ CK+ HLE R LL + K + +E ++ + L+ + +E
Sbjct: 794 LQQDIICKQH------HLESLDR------LLTESKGEMKKENMKKDEALKALQNQVSEET 841
Query: 543 TSNRKRVEELSL---ELSEALRKLE-NSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQ 598
R+ L + EL L +LE N +K ++QL+K +E+ + L H +E
Sbjct: 842 IKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKK-SEEVYCLQKELKIKNHSLQET 900
Query: 599 GSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKL 658
L+ LQ+ ++L+ + + + ++ + +E ++ L QE +K+ ++ E RK+
Sbjct: 901 SEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKM 960
Query: 659 EEENENLRAELQCCSTQLESSLNKYNTSQQV---IQDLNKEIALQKESLMSLQ------- 708
EE+ E+ E + + + T++QV + +E++ ++ +M L+
Sbjct: 961 EEKCESAAHE---ADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKA 1017
Query: 709 ---AQLDKALQKEKHYLQ--TTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKS-- 761
+QLD L + K L+ T KE L + + + +LT+AL+K + +E ++
Sbjct: 1018 MHLSQLDMILDQTKTELEKKTNAVKE----LEKLQHSTETELTEALQKREVLETELQNAH 1073
Query: 762 --LQQSLTQTQEKKAQLEEEIIAYEER---MKKLNTELRKLRGFHQESELEVHAFDKKLE 816
L+ +L Q QE + L++ ++ EE+ +K L ELR+ + ++ + E+ D+ L+
Sbjct: 1074 GELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALK 1133
Query: 817 EMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDT 876
E + ++ Q Q + L M E E ++++ L+ L + + E
Sbjct: 1134 ERNWELKQRAAQVTH-LDMTI--REHRGEMEQKIIKLEGTLEKSELE------------- 1177
Query: 877 CRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQEN 936
L++ KQ + N+KL N +EQ++ EK+ +M+ +QE
Sbjct: 1178 -------------LKECNKQIESLNDKLQNA-KEQLR-------EKEF---IMLQNEQEI 1213
Query: 937 KKLKKEIEEKKMKAENTRLCTKALGPSRTESTQREKVCGTLGWKGLPQDMGQRMDLTK 994
+LKKEIE + + + K ++E+ T + + D+GQ + LT+
Sbjct: 1214 SQLKKEIERTQQRMKEMESVMK----------EQEQYIATQYKEAI--DLGQELRLTR 1259
Score = 119 bits (298), Expect = 1e-26
Identities = 151/717 (21%), Positives = 313/717 (43%), Gaps = 98/717 (13%)
Query: 47 MEEAMNSSHDKKQAQALAFEESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQT 106
+E +N+ H+K LAFE++ K+ HL Q ++++K++ L+ +LE ++ +
Sbjct: 737 LETNINTEHEKI---CLAFEKA-------KKIHLEQHKEMEKQIERLEAQLEKKDQQFKE 786
Query: 107 SYYSLRQYQSILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLAL 166
++ Q D++ HH + + + + EM N E L Q Q++
Sbjct: 787 QEKTMSMLQQ-------DIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSE 839
Query: 167 AGDKIASLERSLNLYRDKYQSSLSNIE-LLECQVKMLQGELGGIMGQEPENKGDHSKVRI 225
K+ L+ +L + +++ L+ +E E K L+ + + + E K + ++
Sbjct: 840 ETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQE 899
Query: 226 YTSPCMIQEH--QETQKRLSEVWQKVSQQDDLIQELRNKLA-CSNALVLEREKALIKLQA 282
+ +I +H Q+ Q+ L + + + +D +L +++ L +RE + KL+
Sbjct: 900 TSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRK 959
Query: 283 DFASC-----------------TATHRYPPSS----SEECEDIKKILKHLQEQKDSQCLH 321
C T T R EE ++K + HL+ +++ +H
Sbjct: 960 MEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMH 1019
Query: 322 VEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCR 381
+ + ++ + ELE +K N +K++ KL+ H E + +++++ T LQ
Sbjct: 1020 LSQLDMILDQTKTELE----KKTNAVKELEKLQ---HSTETELTEALQKREVLETELQNA 1072
Query: 382 LQELQLEFTETQKL--TLKK------DKFLQEKD------EMLQELEKK---LTQVQNSL 424
EL+ + Q+L L+K +K+ KD E E+E K L ++ +L
Sbjct: 1073 HGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQAL 1132
Query: 425 LKKEKELEKQQCMATELEMTVKEAKQD------------KSKEAECKALQAEVQKLKNSL 472
++ EL+++ T L+MT++E + + + E E K +++ L + L
Sbjct: 1133 KERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKL 1192
Query: 473 EEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQ 532
+ AK+Q R Q ++E + +E TQ+++++ + K++ I +E L
Sbjct: 1193 QNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLG 1252
Query: 533 KESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIK 592
+E + ++ ++ + E + +A R++E E +++ E+D N
Sbjct: 1253 QELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGN------- 1305
Query: 593 HQHREQGSIKCK---LEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDK 649
H E G+ K + LE +Q K L + E LK++ E + E A ++K
Sbjct: 1306 HLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHA---KWKISAD 1362
Query: 650 TLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMS 706
+ K + ++L E+ E + EL E + + + Q +QD N+ I E+L++
Sbjct: 1363 SQKSSVQQLNEQLEKAKLEL-------EEAQDTVSNLHQQVQDRNEVIEAANEALLT 1412
Score = 110 bits (275), Expect = 7e-24
Identities = 176/926 (19%), Positives = 394/926 (42%), Gaps = 152/926 (16%)
Query: 12 VSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEESEV- 70
+S L KL + +I+ LH L NQL +++ + +D +++ L+ E+E
Sbjct: 559 ISELRIKLAIKEAEIQKLH-------ANLTANQL--SQSLITCNDSQESSKLSSLETEPV 609
Query: 71 ---------------------EFGSSKQCHLRQLQQLKKKLLVLQQE------------- 96
++ +Q + +++L+ KL+ ++ E
Sbjct: 610 KLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTS 669
Query: 97 -LEFHTEELQTSYYSLRQYQSILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGE 155
+ EEL + + +S + K+ S L+ L K E++++ Y + E
Sbjct: 670 QFQLIQEELLEKASNSSKLESEMTKKCSQLLTLE---KQLEEKIVAYSSIAAKNAE---- 722
Query: 156 KLHLAQEQLALAGDKIASLERSLNLYRDKY--------QSSLSNIELLECQVKMLQGELG 207
+++L +KI SLE ++N +K + L + +E Q++ L+ +L
Sbjct: 723 ----LEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLE 778
Query: 208 GIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRL-----SEVWQKVSQQDDLIQELRNK 262
Q E + S ++ Q H E+ RL E+ ++ ++D+ ++ L+N+
Sbjct: 779 KKDQQFKEQEKTMSMLQ--QDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQ 836
Query: 263 LA--------CSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILK----H 310
++ +AL + +E+ ++ L + + SEE ++K LK
Sbjct: 837 VSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHS 896
Query: 311 LQEQKDSQCL---HVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAH 367
LQE + + +++ Q +++ + + + + + K + KLE +L RE ++
Sbjct: 897 LQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEK 956
Query: 368 IERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKK 427
+ + ++ + E L+ + +LT + E D+ +EL K ++ ++
Sbjct: 957 LRKMEEKC---ESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSK----MEKEIMHL 1009
Query: 428 EKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLE----EAKQQERLAA 483
+++ E + ++L+M + + K + K+ E++KL++S E EA Q+ +
Sbjct: 1010 KRDGENKAMHLSQLDMILDQTKTELEKKTNAVK---ELEKLQHSTETELTEALQKREVLE 1066
Query: 484 QQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQT 543
+ E L++ + LQK L ++K TI++L EL+ + E ++E
Sbjct: 1067 TELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELL 1126
Query: 544 SNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKC 603
+ ++E + EL + ++ + D R+ + + ++ +K+ L+
Sbjct: 1127 EMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLE-------------- 1172
Query: 604 KLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENE 663
K E +L+E K +E ++L+ +KE + E + QE + K ++ ++++E
Sbjct: 1173 KSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMES 1232
Query: 664 NLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQ 723
++ + Q +TQ + ++ DL +E+ L +E + + +L +A ++
Sbjct: 1233 VMKEQEQYIATQYKEAI-----------DLGQELRLTREQVQNSHTELAEARHQQ----- 1276
Query: 724 TTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAY 783
+A + R S+ +D + EK H + L S + +A+++ EI
Sbjct: 1277 ----VQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEI--- 1329
Query: 784 EERMKKLNTELRKLR-GFHQE--SELEVHAFDK--------KLEEMSCQVLQWQKQHQND 832
KKL+ E+ L+ +H E S E HA K +++++ Q+ + + + +
Sbjct: 1330 ----KKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEA 1385
Query: 833 LKMLAAKEEQLREFQEEMAALKENLL 858
++ +Q+++ E + A E LL
Sbjct: 1386 QDTVSNLHQQVQDRNEVIEAANEALL 1411
Score = 98.2 bits (243), Expect = 3e-20
Identities = 124/670 (18%), Positives = 304/670 (45%), Gaps = 49/670 (7%)
Query: 7 ERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFE 66
E+++ +S L ++ Q +++L + + ++ + +EA+ + ++ + +
Sbjct: 786 EQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVR 845
Query: 67 ESEVEFGSSKQ---CHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTS 123
+ + K+ HL QL+ K+K +++L+ +EE+ L+ L++ +
Sbjct: 846 QLDSALEICKEELVLHLNQLEGNKEKF---EKQLKKKSEEVYCLQKELKIKNHSLQETSE 902
Query: 124 DLVLLHHHCKLKEDEVILYEEEMGNHN-ENTGEKL--HLAQEQLALAGDKIASLERSLNL 180
V+L H L++ + +L +E + N E+T KL +++ + L + +S E+ L
Sbjct: 903 QNVILQH--TLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEK-LRK 959
Query: 181 YRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQK 240
+K +S+ +L +V L G + + + K + SK M +E ++
Sbjct: 960 MEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSK--------MEKEIMHLKR 1011
Query: 241 RLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEE 300
+SQ D ++ + + +L V E EK + + + +
Sbjct: 1012 DGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQN 1071
Query: 301 CE-DIKKILKHLQEQKD---SQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELD 356
++K L+ LQE +D L +EE +KDL EL + + +++++++
Sbjct: 1072 AHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQA 1131
Query: 357 LHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKK 416
L +E + ++++ +T L ++E + E ++ +K + L++ + L+E K+
Sbjct: 1132 L----KERNWELKQRAAQVTHLDMTIREHR---GEMEQKIIKLEGTLEKSELELKECNKQ 1184
Query: 417 LTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAK 476
+ + + L +++L +++ + + E + + K+ E + Q ++++++ ++E +
Sbjct: 1185 IESLNDKLQNAKEQLREKEFIMLQNEQEISQLKK------EIERTQQRMKEMESVMKEQE 1238
Query: 477 QQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESS 536
Q ++A +E L ++++ +L + Q I+ L EL+ +++ S
Sbjct: 1239 QYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSK 1298
Query: 537 MAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAE-QDMKMNDMLDRIKHQH 595
EK+ N EEL + +R+ + + +++K AE + +K ++ I HQ
Sbjct: 1299 --EKDAHGNH-LAEELG---ASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQ- 1351
Query: 596 REQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENS 655
+ K K+ D Q+++ ++ EQL+K+K + + + L Q+ + +++ ++ +
Sbjct: 1352 --ENHAKWKISADSQKSS--VQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAAN 1407
Query: 656 RKLEEENENL 665
L + EN+
Sbjct: 1408 EALLTKGENV 1417
Score = 86.7 bits (213), Expect = 1e-16
Identities = 137/699 (19%), Positives = 302/699 (43%), Gaps = 71/699 (10%)
Query: 299 EECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLH 358
+E + +++ L L++Q + CL + + + K + E + + M + + +
Sbjct: 229 QEIKSLREKLNKLRQQ--NACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASV 286
Query: 359 GLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLT 418
+ EE ++E +++ L+E + + ++QK+ ++K++ LQE E +L+ L
Sbjct: 287 PILEEQIINLEA---EVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLL 343
Query: 419 QVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAE-CKALQAEVQKLKNSLEEAKQ 477
+ + E++ + A EL K +Q K K AE + +QAE + L+ +L ++
Sbjct: 344 EQTKQGKRAERQRNEALYNAEELS---KAFQQYKKKVAEKLEKVQAEEEILERNLTNCEK 400
Query: 478 QERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSM 537
+ + ++ K E + L++ R+L++ K+K L+++ ++S
Sbjct: 401 ENKRLQERCGLYKSELEI----LKEKLRQLKEENNNGKEK----------LRIMAVKNSE 446
Query: 538 AEKEQTSNRKRVEELSLEL---SEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQ 594
+ T +R+ + +L EL E LR + E R+L+ VA Q+ +++ I+
Sbjct: 447 VMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESS 506
Query: 595 HREQGSIKCKLEEDLQEATKLLEDK----REQLKKSKEHEKLMEGELEALRQEFKKKDKT 650
E S++ K+ L +L K + Q+ E G EA + +
Sbjct: 507 RVELRSLE-KIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIK 565
Query: 651 LKENSRKLEEENENLRAE------LQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESL 704
L ++++ + NL A + C +Q S L+ T + +++ ++
Sbjct: 566 LAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQ 625
Query: 705 MSLQAQLDKALQKEKHYLQTTITK----EAYDA-----LSRKSAACQDDLTQALEKLNHV 755
++ Q +K Q+ ++ TK EA ++ ++ +++ Q + LEK ++
Sbjct: 626 HTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNS 685
Query: 756 TSETKSLQQSLTQTQEKKAQLEEEIIAY----------EERMKKLNTELRKLR-GFHQES 804
+ + + +Q + QLEE+I+AY E+ + + N ++R L + E
Sbjct: 686 SKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEH 745
Query: 805 ELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENL------L 858
E AF+K + Q + +KQ + L K++Q +E ++ M+ L++++ L
Sbjct: 746 EKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHL 805
Query: 859 EDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQL----REQVKY 914
E + + K+ + D+ + L+ ++ + +L + L E V +
Sbjct: 806 ESLDRLLTESKGEMKKENMK----KDEALKALQNQVSEETIKVRQLDSALEICKEELVLH 861
Query: 915 IAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAENT 953
+ +L G K+ + +E L+KE++ K + T
Sbjct: 862 LNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQET 900
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 133 bits (334), Expect = 1e-30
Identities = 222/950 (23%), Positives = 395/950 (41%), Gaps = 141/950 (14%)
Query: 82 QLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQ---SILEKQTSDLVLLHHHCKLKEDE 138
+L K K+ L+QELE TE+L L Q + L+++ +L+ ++ DE
Sbjct: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDE 311
Query: 139 VILYEEE------MGNHNENTGEKLHLAQEQLA----LAGDKIASLERSLNLYRDKYQSS 188
+ E+ + + E+LH + A L D LE L +
Sbjct: 312 LDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTR 371
Query: 189 LSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQK-----RLS 243
+ +L E + + LQ + + E E D K+ M E + Q L
Sbjct: 372 ARSDKLHELEKENLQLK-AKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLG 430
Query: 244 EVWQKVSQQDDLIQELRNKLACS-NALVLEREKALIKLQADFASCTATHRYPPSSSEECE 302
+++S+ +L + + L N L R L+KL+ + S T T ++ + E
Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELTSSR---LLKLEMENQSLTKTVEELRTTVDSVE 487
Query: 303 -DIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLR 361
+ KILK ++++ VE +N + + L+ +++MK+ +LE + LR
Sbjct: 488 GNASKILK-MEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLR 546
Query: 362 EETSAHI-----ERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKK 416
E + I E + + T+ R Q Q+ K K++K L E ++E K
Sbjct: 547 ENSERQIKILEQENEHLNQTVSSLR-QRSQISAEARVKDIEKENKILHES---IKETSSK 602
Query: 417 LTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLE--E 474
L++++ + +KELE + E E E E + LQ ++ LK + E E
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELHH---LEKENELLQKKITNLKITCEKIE 659
Query: 475 AKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKE 534
A +QE LE RKL+K L D+ + L +L+ L+KE
Sbjct: 660 ALEQEN-----------------SELERENRKLKKTL-------DSFKNLTFQLESLEKE 695
Query: 535 SSMAEKEQTSNRKRVEELSL-ELSEALRKLENSD--KEKRQLQK--TVAEQDMKMNDMLD 589
+S ++E R+ VE L + A +LEN + EK QL+K + + K + L+
Sbjct: 696 NSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLE 755
Query: 590 -----------RIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELE 638
R++ +LE +LQ+ LE + + L+K+ E K+ LE
Sbjct: 756 VSYQGLDIENQRLQKTLENSNKKIQQLESELQD----LEMENQTLQKNLEELKISSKRLE 811
Query: 639 ALRQEFKKKDKT---LKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNK 695
L +E K ++ L+++ ++LE+EN+ LR + + T LE + K ++ + L+K
Sbjct: 812 QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871
Query: 696 EIALQKESLMSLQ--AQLDKALQKEKHYLQTTITKEAYDALSRKSAACQ-----DDLTQA 748
EI + KES + L+ + +K L K T+ D +S K Q + LT
Sbjct: 872 EIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE 931
Query: 749 LEKL----NHVTSETKSLQQSLTQTQEKKAQ--LEEEIIAYEERMKKLNTELRKLRGFHQ 802
LEK+ + + +S S + E K + L++ + EE++ L L + ++Q
Sbjct: 932 LEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQ 991
Query: 803 ESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAK----------EEQLREFQEEMAA 852
+ E+ K E + KQ Q++ +M+ + E + +E E+
Sbjct: 992 QLRQELKTVKKNYEAL--------KQRQDEERMVQSSPPISGEDNKWERESQETTRELLK 1043
Query: 853 LKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQ------QKVANEKLGN 906
+K+ L+E V ++ L + T L+Q Q Q +A ++
Sbjct: 1044 VKDRLIE------------VERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTV 1091
Query: 907 QLREQVKYI----AKLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAEN 952
L+EQ + AKL E L+S L +N +L I++ ++ EN
Sbjct: 1092 SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLL--IQQSSLENEN 1139
Score = 117 bits (294), Expect = 4e-26
Identities = 172/759 (22%), Positives = 336/759 (44%), Gaps = 107/759 (14%)
Query: 232 IQEHQETQKRLSEV-WQKVSQ--QDDLIQELRNKLACSNALVLEREK---ALIKLQADFA 285
IQE Q+ + ++ W +V+ Q+D+ L+N L+ ER++ +I+L +
Sbjct: 160 IQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEER- 218
Query: 286 SCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRN 345
H P +SS E + + + + + ++ LR ELE +EQ +
Sbjct: 219 --DGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLD 276
Query: 346 IMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQE 405
+++ ++E++L L++E + ++ + + + L L+ + KL + ++
Sbjct: 277 CKQELEQMEIELKRLQQE-NMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRY--- 332
Query: 406 KDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEV 465
E L ++E +V+ + LE + + +LE T A+ DK E E + LQ
Sbjct: 333 -KERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGT--RARSDKLHELEKENLQ--- 386
Query: 466 QKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQ 525
LK L + + + + ++ + EE LE Q KQ D L
Sbjct: 387 --LKAKLHDMEMERDMDRKKIEELMEE----NMTLEMAQ----------KQSMDESLHLG 430
Query: 526 RELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMN 585
EL+ + + S ++E Q S V EL+ S L KLE E + L KTV E +
Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELT---SSRLLKLE---MENQSLTKTVEE----LR 480
Query: 586 DMLDRIKHQHREQGSIKCKLEEDLQEATK---LLEDKREQLKKSKEHEKLMEGELEALRQ 642
+D ++ S K+E++ Q +K +LE++ Q K+S ++ + + +L +
Sbjct: 481 TTVDSVEGN----ASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
Query: 643 EFKKKDKTLKENSRK----LEEENENLRAELQCCSTQLESSLNKYN--TSQQVIQDLNKE 696
+ +K +TL+ENS + LE+ENE+L Q SSL + + +++ ++D+ KE
Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHLN--------QTVSSLRQRSQISAEARVKDIEKE 588
Query: 697 IALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVT 756
+ ES+ ++L K ++ EK ++ + E Y ++ +++L +H+
Sbjct: 589 NKILHESIKETSSKLSK-IEFEKRQIKKEL--EHYKEKGERAEELENEL-------HHLE 638
Query: 757 SETKSLQQSLTQ---TQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDK 813
E + LQ+ +T T EK LE+E +++ N +L+K + ++ + +K
Sbjct: 639 KENELLQKKITNLKITCEKIEALEQE----NSELERENRKLKKTLDSFKNLTFQLESLEK 694
Query: 814 KLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVP 873
+ ++ + L+ ++ ++ LK + K QL+ +E+ + KE L
Sbjct: 695 ENSQLDEENLELRRNVES-LKCASMKMAQLQLENKELESEKEQL---------------- 737
Query: 874 KDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQ 933
K L + + + LE + + N++L L K I +L E + L+
Sbjct: 738 KKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESE-------LQDLE 790
Query: 934 QENKKLKKEIEEKKMKAENTRLCTKALGPSRTESTQREK 972
EN+ L+K +EE K+ ++ K E++Q EK
Sbjct: 791 MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEK 829
Score = 111 bits (278), Expect = 3e-24
Identities = 200/958 (20%), Positives = 385/958 (40%), Gaps = 131/958 (13%)
Query: 3 DEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQA 62
D+ E ++E L +KL ++++ D+ +++ + L + + +E A S D+
Sbjct: 375 DKLHELEKENLQLKAKLHDMEME----RDMDRKKIEELMEENMTLEMAQKQSMDESLHLG 430
Query: 63 LAFEE----SEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHT---EELQTSYYSLRQYQ 115
E+ SE+ K + +LL L+ E + T EEL+T+ S+
Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNA 490
Query: 116 SILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIA-SL 174
S + K + L ++ E+E++ ++ + N +N + L + QL + + +
Sbjct: 491 SKILKMEKENQRLSKKVEILENEIVQEKQSLQNC-QNLSKDLMKEKAQLEKTIETLRENS 549
Query: 175 ERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQE 234
ER + + + + + L Q + E + E ENK H ++ +S E
Sbjct: 550 ERQIKILEQENEHLNQTVSSLR-QRSQISAE-ARVKDIEKENKILHESIKETSSKLSKIE 607
Query: 235 HQETQ--KRLSEVWQKVSQQDDLIQELRN---------------KLACSNALVLEREKA- 276
++ Q K L +K + ++L EL + K+ C LE+E +
Sbjct: 608 FEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSE 667
Query: 277 -------LIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLV 329
L K F + T + + ++ L+ E + + + Q
Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
Query: 330 KDLRVELEAVS---EQKRNIMKDMMKLELDLHGL---REETSAHIERKDKDITILQCRLQ 383
K+L E E + E + K +LE+ GL + +E +K I L+ LQ
Sbjct: 728 KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQ 787
Query: 384 ELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQC---MATE 440
+L++E QK L++ K ++ E L++ K L Q + L K +K+LEK+ E
Sbjct: 788 DLEMENQTLQK-NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE 846
Query: 441 LEMTVKEAKQDK--SKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGC 498
++ T E K + E E K L E+ K S K+ E+ + + + A +
Sbjct: 847 IKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEK----ENKELVKRATIDIK 902
Query: 499 HLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQ-KESSMAEKEQTSNRKRVEELSLELS 557
L + L L +Q + +++L EL+ + + + EQ+++ R + L +L
Sbjct: 903 TLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLE 962
Query: 558 EALRKLENSDKEKRQLQKTVAEQDMKMNDML-----------DRIKHQHREQGSIKC--- 603
L+K +EK + E+ N L + +K + E+ ++
Sbjct: 963 STLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPP 1022
Query: 604 ------KLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKK----------- 646
K E + QE T+ L +++L + + + ++ E +AL+ + K+
Sbjct: 1023 ISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQ 1082
Query: 647 -------------KDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDL 693
++ TL+ + KL+ EN L ++ ST L + + Q +++
Sbjct: 1083 ILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ----STSLMNQNAQLLIQQSSLENE 1138
Query: 694 NKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLN 753
N+ + ++E L SL L K EK L Y++L K L A + L
Sbjct: 1139 NESVIKEREDLKSLYDSLIK--DHEKLELLHERQASEYESLISKHGT----LKSAHKNLE 1192
Query: 754 HVTSETKSLQQSLTQTQEKKAQLE----------EEIIAYEERMKKLNTELRKLRGFHQE 803
E + L+ Q ++K QLE E+++ + + + E +KL G E
Sbjct: 1193 ---VEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCG---E 1246
Query: 804 SELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDD 861
++ H + + L+E +VL Q H+N +L + + + E + LKE + D
Sbjct: 1247 NDRLNHTYSQLLKE--TEVL--QTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLD 1300
Score = 94.4 bits (233), Expect = 5e-19
Identities = 187/792 (23%), Positives = 325/792 (41%), Gaps = 133/792 (16%)
Query: 3 DEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDN------------------- 43
+ A E + E+ L + LQ I NL C++ Q+N
Sbjct: 625 ERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKN 684
Query: 44 ---QLCMEEAMNSSHDKKQAQALAFEESEVEFGSSKQCHLR--------QLQQLKKKLLV 92
QL E NS D++ + ES ++ S K L+ + +QLKK L +
Sbjct: 685 LTFQLESLEKENSQLDEENLELRRNVES-LKCASMKMAQLQLENKELESEKEQLKKGLEL 743
Query: 93 LQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHN-E 151
L+ + TE L+ SY L +E Q L + + K+++ E L + EM N +
Sbjct: 744 LKASFK-KTERLEVSYQGLD-----IENQRLQKTLENSNKKIQQLESELQDLEMENQTLQ 797
Query: 152 NTGEKLHLAQEQLALAGDKIASLERSLN-LYRDKYQSSLSNIEL---LECQVKMLQGELG 207
E+L ++ ++L + SLE+ + L +DK Q N L E + L+
Sbjct: 798 KNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNV 857
Query: 208 GIMGQEPENKGDHSKVRIYTSPC-----MIQEHQETQKRLS-EVWQKVSQQDDLIQELRN 261
I E ENK ++ IY C + +E++E KR + ++ V+ ++DL+ E
Sbjct: 858 KIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLK 917
Query: 262 KLACSNALV----------LEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHL 311
+N L L +E+ L Q+ T RY S+ +KK L+
Sbjct: 918 TQQMNNDLEKLTHELEKIGLNKERLLHDEQS-----TDDSRYKLLESKLESTLKKSLEIK 972
Query: 312 QEQKDSQCLHVEEYQNLVKDLRVELEAVSE-----QKRNIMKDMMKLELDLHG------- 359
+E+ + +EE N + LR EL+ V + ++R + M++ + G
Sbjct: 973 EEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWER 1032
Query: 360 -LREETSAHIERKDKDITI------LQCRLQEL--QLEFTETQKLTL--------KKDKF 402
+E T ++ KD+ I + LQ Q L QL+ ETQ L ++
Sbjct: 1033 ESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS 1092
Query: 403 LQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQ 462
LQE++ LQ KL QV+NS L + M ++ ++++ + E+ K +
Sbjct: 1093 LQEQNTTLQTQNAKL-QVENSTLNSQST----SLMNQNAQLLIQQSSLENENESVIKERE 1147
Query: 463 AEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQ 522
+++ L +SL K E+L Q E +L H T + K L ++ + +
Sbjct: 1148 -DLKSLYDSL--IKDHEKLELLHERQASEYESLISKH--GTLKSAHKNLEVEHRDLE--- 1199
Query: 523 ELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDM 582
R Q+L+++ + + E+ L++ + LEN + E TVA +
Sbjct: 1200 --DRYNQLLKQKGQLEDLEKM----------LKVEQEKMLLENKNHE------TVAAEYK 1241
Query: 583 KMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLED-KREQLKKSKEHEKLMEG--ELEA 639
K+ DR+ H + + L+ D + LL + K EQ + E KL E +L+
Sbjct: 1242 KLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDI 1301
Query: 640 LRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNK-------YNTSQQVIQD 692
+ + + L + LEEEN +L ++Q Q + L + ++ Q+ D
Sbjct: 1302 TSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYID 1361
Query: 693 LNKEIALQKESL 704
E+ QKE L
Sbjct: 1362 KLNELRRQKEKL 1373
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 133 bits (334), Expect = 1e-30
Identities = 201/1029 (19%), Positives = 448/1029 (43%), Gaps = 147/1029 (14%)
Query: 4 EAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQAL 63
E ER + +N++L + + + L D C +K + D +L + + H
Sbjct: 925 EVTERAEDEEEINAELTAKK---RKLEDECSELKKDIDDLELTLAKVEKEKHAT------ 975
Query: 64 AFEESEVEFGSSKQCHLRQ-LQQLKKKLLVLQQELEFHTEELQTS---YYSLRQYQSILE 119
E++V+ + + L + + +L K+ LQ+ + ++LQ +L + + LE
Sbjct: 976 ---ENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLE 1032
Query: 120 KQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLN 179
+Q DL G+ + ++ L + + L GD + E +++
Sbjct: 1033 QQVDDLE--------------------GSLEQEKKIRMDLERAKRKLEGDLKLAQESTMD 1072
Query: 180 LYRDKYQSSLSNIELLECQVKMLQGELGGIMG--QEPENKGDHSKVRIYTSPCMIQEHQE 237
+ DK Q L+ ++K + E+ G+ ++ + G + +I I+E +E
Sbjct: 1073 IENDKQQ--------LDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEE 1124
Query: 238 -----------TQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFAS 286
+K+ S++ +++ + + ++E + + +RE K++ D
Sbjct: 1125 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1184
Query: 287 CTATHRYPPSS------------SEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRV 334
T H ++ E+ ++++++ + L+++K + ++ DL
Sbjct: 1185 ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID-------DLAS 1237
Query: 335 ELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQ--------ELQ 386
+E VS+ K N+ K LE L ++ + +R D+T + RLQ +L
Sbjct: 1238 NMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQ-QRLINDLTAQRARLQTESGEYSRQLD 1296
Query: 387 LEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQ-------VQNSL----LKKEKELEKQQ 435
+ T +L+ K F Q+ +E+ ++LE+++ +Q+S L +E+ E+Q+
Sbjct: 1297 EKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQE 1356
Query: 436 CMATELEMTVKEAKQDKSK---EAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEE 492
A EL+ + +A + ++ + E A+Q + LEEAK++ Q A + E
Sbjct: 1357 AKA-ELQRAMSKANSEVAQWRTKYETDAIQRTEE-----LEEAKKKLAQRLQDAEEHVEA 1410
Query: 493 AALAGCHLEDTQRKLQ---KGLLLDKQKADT----IQELQRELQMLQKESSMAEKEQTSN 545
LE T+++LQ + L++D ++ + + + QR + E +E +
Sbjct: 1411 VNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAE 1470
Query: 546 RKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKL 605
+ ++ S LS L K++N+ +E +T+ ++ + + + Q E G +L
Sbjct: 1471 LEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHEL 1530
Query: 606 EE---DLQEATKLLEDKREQLKKSKEHE--KLMEGELEALRQEFKKKDKTLKENSRKLEE 660
E+ +++ L+ E+ + S EHE K++ +LE L Q + D+ + E ++++
Sbjct: 1531 EKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLE-LNQVKSEVDRKIAEKDEEIDQ 1589
Query: 661 ENENLRAELQCCSTQLESSLNKYNTS----QQVIQDLNK-EIALQKESLMSLQAQLD--- 712
N ++ + L++ + N + +++ DLN+ EI L + M+ +A +
Sbjct: 1590 MKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRN 1649
Query: 713 -KALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQE 771
+A+ K+ T+ D R ++ L + N + +E + L+ +L QT+
Sbjct: 1650 TQAILKD--------TQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTER 1701
Query: 772 KKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQN 831
+ E+E++ ER++ L+T+ L ++ E ++ ++E++ + +++ +
Sbjct: 1702 SRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKK 1761
Query: 832 DLKMLAAKEEQLREFQEEMAAL---KENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQI-- 886
+ A E+L++ Q+ A L K+NL + K+ L + L G QI
Sbjct: 1762 AITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKD---LQHRLDEAEQLALKGGKKQIQK 1818
Query: 887 ----MTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKE 942
+ LE + ++ N + LR+ + + +L+ + + ++ LQ KL+ +
Sbjct: 1819 LEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAK 1878
Query: 943 IEEKKMKAE 951
++ K +AE
Sbjct: 1879 VKSYKRQAE 1887
Score = 104 bits (260), Expect = 4e-22
Identities = 142/731 (19%), Positives = 298/731 (40%), Gaps = 71/731 (9%)
Query: 272 EREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQC---------LHV 322
E EK + ++ +F + +E E+ K++ +QE+ D Q
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEE--KMVTLMQEKNDLQLQVQAEADSLADA 905
Query: 323 EEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRL 382
EE + + +++LEA ++ +D ++ +L + + KDI L+ L
Sbjct: 906 EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 965
Query: 383 QELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQ-------NSLLKKEKELEKQQ 435
+++ E T+ + + DE + +L K+ +Q + L +E ++
Sbjct: 966 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLT 1025
Query: 436 CMATELEMTVKEAKQDKSKEAECKA-LQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAA 494
+LE V + + +E + + L+ +KL+ L+ A++ Q E+
Sbjct: 1026 KAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLK 1085
Query: 495 LAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKE-------SSMAEKEQTSNRK 547
+ Q K++ L Q I+ELQ ++ L++E + AEK+++ +
Sbjct: 1086 KKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR 1145
Query: 548 RVEELSLELSEA----LRKLENSDKEKRQLQK--------------TVAEQDMKMNDMLD 589
+EE+S L EA ++E + K + + QK T A K D +
Sbjct: 1146 ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVA 1205
Query: 590 RIKHQHREQGSIKCKLEEDLQEATKLLED---KREQLKKSKEHEKLMEGELEALRQEFKK 646
+ Q +K KLE++ E ++D E + K+K + + M LE E K
Sbjct: 1206 ELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKT 1265
Query: 647 KDKTLKENSRKLEEENENLRAELQCCSTQLESS---LNKYNTSQQVIQDLNKEIALQKES 703
K++ + L + L+ E S QL+ +++ + +Q +E+ Q E
Sbjct: 1266 KEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEE 1325
Query: 704 LMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLN--HVTSETKS 761
+ ++ L ALQ +H + +E Y+ A Q +++A ++ ET +
Sbjct: 1326 EIKAKSALAHALQSSRH--DCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDA 1383
Query: 762 LQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQ 821
+Q++ + +E K +L + + EE ++ +N + L Q + EV +E +
Sbjct: 1384 IQRT-EELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAA 1442
Query: 822 VLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYR 881
K+ +N K+LA +++ E E+ A ++ S+ + ++
Sbjct: 1443 CAALDKKQRNFDKILAEWKQKCEETHAELEASQKE------------SRSLSTELFKIKN 1490
Query: 882 GNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKK 941
++ + LE ++ N+ L ++ + + IA+ L + ++QE +L+
Sbjct: 1491 AYEESLDQLETLKRE----NKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQA 1546
Query: 942 EIEEKKMKAEN 952
+EE + E+
Sbjct: 1547 ALEEAEASLEH 1557
Score = 83.2 bits (204), Expect = 1e-15
Identities = 132/757 (17%), Positives = 318/757 (42%), Gaps = 117/757 (15%)
Query: 1 MKDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQA 60
++ E E E+ L S + ++ NL +C+ L + + EE +D
Sbjct: 1221 LEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQ 1280
Query: 61 QA-LAFEESEV------------EFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTS 107
+A L E E + KQ +Q+++LK++L + LQ+S
Sbjct: 1281 RARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSS 1340
Query: 108 YYSL----RQYQSILEKQTSDLVLLHHHCKLK----------EDEVILYEEEMGNHNENT 153
+ QY+ E+Q + L K E + I EE+ +
Sbjct: 1341 RHDCDLLREQYE---EEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKL 1397
Query: 154 GEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKML---QGELGGIM 210
++L A+E + K ASLE++ +++ + + ++E L Q I+
Sbjct: 1398 AQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKIL 1457
Query: 211 GQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALV 270
E + K + + + S +E++ +E+++ + ++ + +L
Sbjct: 1458 A-EWKQKCEETHAELEAS------QKESRSLSTELFKIKNAYEESLDQLET--------- 1501
Query: 271 LEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVK 330
L+RE LQ + + T + +++KI K ++++K
Sbjct: 1502 LKRENK--NLQQEISDLT---EQIAEGGKRIHELEKIKKQVEQEKS-------------- 1542
Query: 331 DLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFT 390
+L+ LE + +++++L+L+ ++ E I KD++I +++ +
Sbjct: 1543 ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID----QMKRNHIRIV 1598
Query: 391 ETQKLTL-----KKDKFLQEKDEM---LQELEKKLTQVQNSLLKKEKELEKQQCMATELE 442
E+ + TL ++ ++ K +M L E+E +L + + Q + + +
Sbjct: 1599 ESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQ 1658
Query: 443 MTVKEAKQDKSK--------EAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAA 494
+ + +A + + E LQAE+++L+ +LE+ ++ ++A Q+ E
Sbjct: 1659 LHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQ 1718
Query: 495 LAGCHLEDTQRKLQKGLLLDKQKADT-IQELQRELQMLQKESSMAEKEQTSNRKRVEELS 553
L H ++T L+ K+K +T I ++Q E++ + +E+ AE++ +K + + +
Sbjct: 1719 LL--HTQNTS------LINTKKKLETDISQIQGEMEDIIQEARNAEEKA---KKAITDAA 1767
Query: 554 LELSEALRKLENS---DKEKRQLQKTVAEQDMKMND-----------MLDRIKHQHRE-Q 598
+ E ++ + S ++ K+ L++TV + ++++ + +++ + RE +
Sbjct: 1768 MMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELE 1827
Query: 599 GSIKCKLEEDLQEATKLLEDKRE--QLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSR 656
G ++ + + +++ L + +R+ +L E ++ L+ L + + K K+ K +
Sbjct: 1828 GEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE 1887
Query: 657 KLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDL 693
+ EE++ ++ + +LE + + + ++ + L
Sbjct: 1888 EAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKL 1924
Score = 75.1 bits (183), Expect = 3e-13
Identities = 88/464 (18%), Positives = 201/464 (43%), Gaps = 25/464 (5%)
Query: 505 RKLQKGLLLDKQKADTIQELQR---ELQMLQKESSMAEKEQTSNRKRVEELSLELSEALR 561
+ L K +K+ A+ +E ++ EL + + E++ + + +L L++
Sbjct: 841 KPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEAD 900
Query: 562 KLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKRE 621
L ++++ QL KT + + K+ ++ +R + + ++ +L + LED+
Sbjct: 901 SLADAEERCDQLIKTKIQLEAKIKEVTERAEDEE--------EINAELTAKKRKLEDECS 952
Query: 622 QLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLN 681
+LKK + +L ++E + + K K L E L+E L E + + +L+
Sbjct: 953 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1012
Query: 682 KYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAA- 740
+ + L K ++ + L+ L++ + + E L+++S
Sbjct: 1013 DLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMD 1072
Query: 741 CQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGF 800
++D Q EKL E LQ + Q QL+++I + R+++L E+ R
Sbjct: 1073 IENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERAS 1132
Query: 801 HQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLED 860
++E + ++LEE+S ++ + ++M +E EFQ+ L+E L+
Sbjct: 1133 RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKRE---AEFQKMRRDLEEATLQH 1189
Query: 861 DKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSG 920
+ L + K + +QI NL++ ++ + ++ ++ + + +S
Sbjct: 1190 EATAATLRK----KHADSVAELGEQI-DNLQRVKQKLEKEKSEMKMEIDDLASNMETVSK 1244
Query: 921 EKDHLHSVMVHLQQENKKLKKEIEEKK-----MKAENTRLCTKA 959
K +L + L+ + ++K + EE++ + A+ RL T++
Sbjct: 1245 AKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTES 1288
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 129 bits (324), Expect = 1e-29
Identities = 145/663 (21%), Positives = 284/663 (42%), Gaps = 36/663 (5%)
Query: 315 KDSQCLHVEEYQNLVKDLRVELEAVSEQ---KRNIMKDMMKLELDLHGLREETSAHIERK 371
K+ + + V E Q ++ E+E + Q ++ +++ ++ E +L EE A + K
Sbjct: 850 KEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAK 909
Query: 372 DKDITI----LQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKK 427
+++ L+ R++E + Q K + +QE +E L+E E ++Q +
Sbjct: 910 KQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTT 969
Query: 428 E---KELEKQQCMATELEMTV-KEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAA 483
E K+LE++Q + + + KE K + + AE E ++ SL + K +
Sbjct: 970 EAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMI 1029
Query: 484 QQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQT 543
+ LE T+RKL+ +D I ELQ ++ L+ + + E+E
Sbjct: 1030 TDLEERLRREEKQRQELEKTRRKLEGD---STDLSDQIAELQAQIAELKMQLAKKEEELQ 1086
Query: 544 SNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKC 603
+ RVEE + + + AL+K+ + + +LQ+ + + N + + E ++K
Sbjct: 1087 AALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKT 1146
Query: 604 KLEEDLQE--ATKLLEDKREQ----LKKSKEHE-KLMEGELEALRQEFKKKDKTLKENSR 656
+LE+ L A + L KREQ LKK+ E E K E +++ +RQ+ + + L E
Sbjct: 1147 ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206
Query: 657 KLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQ 716
+ + NL Q + N+ Q D + + L LQ + ++ +
Sbjct: 1207 QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEG-E 1265
Query: 717 KEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQL 776
+ + L +TK + + Q D K + +T + +L+ L TQE +
Sbjct: 1266 RVRTELADKVTKLQVELDNVTGLLSQSD-----SKSSKLTKDFSALESQLQDTQELLQEE 1320
Query: 777 EEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKML 836
+ ++ ++K++ E R +E E H +K++ + QV +K+ ++ + L
Sbjct: 1321 NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCL 1380
Query: 837 AAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLE---QW 893
EE R+ Q+++ L + E + K RL + D ++ +L+ Q
Sbjct: 1381 ETAEEVKRKLQKDLEGLSQR-----HEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQS 1435
Query: 894 AKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEE-KKMKAEN 952
A + +K L E+ AK + E+D + + + L + +EE + KAE
Sbjct: 1436 ACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAEL 1495
Query: 953 TRL 955
RL
Sbjct: 1496 ERL 1498
Score = 127 bits (319), Expect = 5e-29
Identities = 214/1047 (20%), Positives = 424/1047 (40%), Gaps = 173/1047 (16%)
Query: 5 AGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCME--EAMNSSHDKKQAQA 62
A R E+ +L S+L++ +L + Q + + +LC E E KKQ
Sbjct: 864 AENRLTEMETLQSQLMAEKLQL---------QEQLQAETELCAEAEELRARLTAKKQELE 914
Query: 63 LAFEESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQT 122
+ E ++ + LQ KKK+ QELE EE +++ L+ LEK T
Sbjct: 915 EICHDLEARVEEEEE-RCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQ-----LEKVT 968
Query: 123 SD----------LVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDK-- 170
++ ++L +CKL +++ +L E+ + N E+ ++ L
Sbjct: 969 TEAKLKKLEEEQIILEDQNCKLAKEKKLL-EDRIAEFTTNLTEEEEKSKSLAKLKNKHEA 1027
Query: 171 -IASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSP 229
I LE L + Q LE L ++ + Q E K +K
Sbjct: 1028 MITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQA 1087
Query: 230 CMIQEHQETQKR---LSEVWQKVSQQDDLIQELRNKLACSNA-------LVLEREKALIK 279
+ + +E ++ L ++ + SQ +L ++L ++ A N L E E +
Sbjct: 1088 ALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTE 1147
Query: 280 LQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHV-EEYQNLVKDLRVELEA 338
L+ S A +E +KK L+ + ++Q + +++ V++L +LE
Sbjct: 1148 LEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQ 1207
Query: 339 VSEQKRNIMKDMMKLELDLHGLREETSAHIERK---DKDITILQCRLQELQLEFTETQ-- 393
K N+ K LE + L E ++ K + ++ +LQELQ++F E +
Sbjct: 1208 TKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERV 1267
Query: 394 ---------KLTLKKDK---FLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATEL 441
KL ++ D L + D +L K + +++ L ++ L+++ L
Sbjct: 1268 RTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSL 1327
Query: 442 EMTVKEAKQDKSK---------------EAECKALQAEVQKLKNSLE----------EAK 476
+K+ + +K+ E + L A+V +K +E E K
Sbjct: 1328 STKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVK 1387
Query: 477 QQERLAAQQAAQCKEEAALAGCHLEDTQRKLQK---GLLLD----KQKADTIQELQREL- 528
++ + + +Q EE A LE T+ +LQ+ LL+D +Q A +++ Q++
Sbjct: 1388 RKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFD 1447
Query: 529 QMLQKESSMAEK--------EQTSNRKRVEELSLE--LSEAL------------------ 560
Q+L +E +++ K E + K + LSL L EA+
Sbjct: 1448 QLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEME 1507
Query: 561 ----------RKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQ-------GSIKC 603
+ + +K KR L++ V E ++ ++ D ++ + ++K
Sbjct: 1508 DLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKA 1567
Query: 604 KLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQE-------FKKKDKTLKENSR 656
+ E DLQ + E+K++QL + ME ELE R++ KK + LK+
Sbjct: 1568 QFERDLQGRDEQSEEKKKQLVRQVRE---MEAELEDERKQRSMAVAARKKLEMDLKDLEA 1624
Query: 657 KLEEENEN----------LRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMS 706
++ N+N L+A+++ C +L+ + ++ K++ + ++
Sbjct: 1625 HIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQ 1684
Query: 707 LQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSL 766
LQ +L A + ++ ++ D L+ + A ALE+ + + L++ L
Sbjct: 1685 LQEELAAAERAKRQ------AQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEEL 1738
Query: 767 TQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQ 826
+ Q + + + ++ ++NT+L R Q++E +++ +E+ ++ + +
Sbjct: 1739 EEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEME 1798
Query: 827 ----KQHQNDLKMLAAK----EEQL-REFQEEMAALKENLLEDDKEPCCLPQWSVPKDTC 877
+++ + L AK EEQL E +E AA K+ + K L Q +
Sbjct: 1799 GTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNA 1858
Query: 878 RLYRGN-DQIMTNLEQWAKQQKVANEK 903
Y+ D+ T L+Q +Q + A E+
Sbjct: 1859 EQYKDQADKASTRLKQLKRQLEEAEEE 1885
Score = 116 bits (291), Expect = 9e-26
Identities = 168/753 (22%), Positives = 333/753 (44%), Gaps = 104/753 (13%)
Query: 247 QKVSQQDDLIQELRNKLACSNALV--------LEREKALIK--LQADFASCTATHRY--- 293
+ ++++++L++ +LA N L L EK ++ LQA+ C
Sbjct: 846 EMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRAR 905
Query: 294 ----PPSSSEECEDIKKILKHLQEQKDSQCLHVE----EYQNLVKDLRVELEAVSEQKRN 345
E C D++ + E+++ +C H++ + Q +++L +LE ++
Sbjct: 906 LTAKKQELEEICHDLEARV----EEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQK 961
Query: 346 IMKDMMKLELDLHGLREETSAHIERK---DKDITILQCRLQELQLEFTETQKLTLKKDKF 402
+ + + E L L EE ++ K+ +L+ R+ E TE ++ + K
Sbjct: 962 LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKL 1021
Query: 403 LQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQ 462
+ + M+ +LE++L + + + EK K + +T+L + E LQ
Sbjct: 1022 KNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE-------------LQ 1068
Query: 463 AEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDK--QKADT 520
A++ +LK L AK++E L A A+ +EEAA QK + L K +
Sbjct: 1069 AQIAELKMQL--AKKEEELQA-ALARVEEEAA-------------QKNMALKKIRELESQ 1112
Query: 521 IQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKL-------ENSDKEKRQL 573
I ELQ +L+ + + AEK++ + +E L EL + L ++E L
Sbjct: 1113 ISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNIL 1172
Query: 574 QKTVAEQDMKMNDMLDRIKHQH-------REQGSIKCKLEEDLQEATKLLEDKREQLKKS 626
+KT+ E+ + ++ +H EQ +++ +L++A + LE++R +L +
Sbjct: 1173 KKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGEL--A 1230
Query: 627 KEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTS 686
E + L++G+ ++ + KK + L+E K E E +R EL T+L+ L+ N +
Sbjct: 1231 NEVKVLLQGKGDS-EHKRKKVEAQLQELQVKF-NEGERVRTELADKVTKLQVELD--NVT 1286
Query: 687 QQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLT 746
+ Q +K L K+ + L+ LQ + LQ ++ +LS K +D+
Sbjct: 1287 GLLSQSDSKSSKLTKDF-----SALESQLQDTQELLQEENRQKL--SLSTKLKQVEDEKN 1339
Query: 747 QALEKLNHVTSETKSLQQSLTQTQEKKAQLE---EEIIAYEERMKKLNTELRK-LRGFHQ 802
E+L +L++ + + A ++ E+ + E +++ +L+K L G Q
Sbjct: 1340 SFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQ 1399
Query: 803 ESELEVHAFDKKLEEMSCQVLQWQKQHQNDL----KMLAAKEEQLREFQEEMAALKENLL 858
E +V A+D KLE+ ++ Q DL + E++ ++F + +A K
Sbjct: 1400 RHEEKVAAYD-KLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISA 1458
Query: 859 EDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKL 918
+ +E + K+T L + LE+ A +QK E+L Q R +++ L
Sbjct: 1459 KYAEERDRAEAEAREKETKAL-----SLARALEE-AMEQKAELERLNKQFRTEME---DL 1509
Query: 919 SGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAE 951
KD + + L++ + L++++EE K + E
Sbjct: 1510 MSSKDDVGKSVHELEKSKRALEQQVEEMKTQLE 1542
Score = 100 bits (250), Expect = 5e-21
Identities = 158/754 (20%), Positives = 320/754 (42%), Gaps = 121/754 (16%)
Query: 1 MKDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQA 60
M+ + + E++ + ++ +++ + +R L + + + S K++
Sbjct: 1190 MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKK 1249
Query: 61 QALAFEESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTS------------- 107
+E +V+F + R +L K+ LQ EL+ T L S
Sbjct: 1250 VEAQLQELQVKFNEGE----RVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSA 1305
Query: 108 -YYSLRQYQSILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLAL 166
L+ Q +L+++ + L K EDE + E++ E E H ++Q+A
Sbjct: 1306 LESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQL----EEEEEAKHNLEKQIAT 1361
Query: 167 AGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPE-----NKGDHS 221
++A +++ K + S+ +E E + LQ +L G+ + E +K + +
Sbjct: 1362 LHAQVADMKK-------KMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKT 1414
Query: 222 KVRIYT--------------SPCMIQEHQETQKRLSEVWQKVS-----QQDDLIQELRNK 262
K R+ S C +++ Q+ +L + +S ++D E R K
Sbjct: 1415 KTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREK 1474
Query: 263 ----LACSNAL--VLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKD 316
L+ + AL +E++ L +L F T SS++ D+ K + L++ K
Sbjct: 1475 ETKALSLARALEEAMEQKAELERLNKQFR----TEMEDLMSSKD--DVGKSVHELEKSKR 1528
Query: 317 SQCLHVEEYQNLVKDLRVELEAVSEQKR----NIMKDMMKLELDLHGLREETSAHIERKD 372
+ VEE + +++L EL+A + K N+ + E DL G E++ E K
Sbjct: 1529 ALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQS----EEKK 1584
Query: 373 KDITILQCRLQELQLEFTETQK----------------LTLKKDKFLQEKDEMLQELEKK 416
K + + Q R E +LE Q+ L D + +DE +++L K
Sbjct: 1585 KQL-VRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKL 1643
Query: 417 LTQVQNSLLKKEKELEKQQCMATELEMTVKE-AKQDKSKEAECKALQAEVQKLKNSLEEA 475
Q+++ + +EL+ + E+ KE K+ KS EAE LQ E+ + + +A
Sbjct: 1644 QAQMKDCM----RELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQA 1699
Query: 476 KQQERLAAQQAAQCKEEAALAGCHLEDTQR------KLQKGLLLDKQKADTIQELQRELQ 529
+Q+ A + A + ALA LE+ +R +L++ L ++ + I + ++
Sbjct: 1700 QQERDELADEIANSSGKGALA---LEEKRRLEARIAQLEEELEEEQGNTELINDRLKKAN 1756
Query: 530 M--------LQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQD 581
+ L E S A+K + + R+++E + EL L+++E + K K + T E
Sbjct: 1757 LQIDQINTDLNLERSHAQKNENA-RQQLERQNKELKVKLQEMEGTVKSKYKASITALEAK 1815
Query: 582 M-KMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKR-------EQLKKSKEHEKLM 633
+ ++ + LD + + + E+ L++ ++D+R +Q K+ K +
Sbjct: 1816 IAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQL 1875
Query: 634 EGELEALRQEFKKKDKTLKENSRKLEEENENLRA 667
+ +LE +E ++ + + ++ R+LE+ E A
Sbjct: 1876 KRQLEEAEEEAQRANASRRKLQRELEDATETADA 1909
Score = 94.0 bits (232), Expect = 6e-19
Identities = 146/716 (20%), Positives = 298/716 (41%), Gaps = 144/716 (20%)
Query: 385 LQLEFTETQKLTLKKDKFLQ--EKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELE 442
L+L + +L K LQ ++E + E++L +V+ L E L + + + ++L
Sbjct: 820 LKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLM 879
Query: 443 MTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQ-ERLAAQQAAQCKEEAALAGCHLE 501
+ ++ E E L AE ++L+ L KQ+ E + A+ +EE HL+
Sbjct: 880 AEKLQLQEQLQAETE---LCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQ-HLQ 935
Query: 502 DTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALR 561
++K+Q+ IQEL+ +L+ E+ S R++++ + L+
Sbjct: 936 AEKKKMQQN----------IQELEEQLE-----------EEESARQKLQLEKVTTEAKLK 974
Query: 562 KLENSD-----------KEKRQLQKTVAE------QDMKMNDMLDRIKHQHREQGSIKCK 604
KLE KEK+ L+ +AE ++ + + L ++K++H
Sbjct: 975 KLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHE-------A 1027
Query: 605 LEEDLQEATKLLEDKREQLKKSK-----------EHEKLMEGELEALRQEFKKKDKTLKE 653
+ DL+E + E +R++L+K++ + ++ ++ L+ + KK++ L+
Sbjct: 1028 MITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQA 1087
Query: 654 NSRKLEEEN----------ENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKES 703
++EEE L +++ LES N +++ +DL +E+ K
Sbjct: 1088 ALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTE 1147
Query: 704 L------MSLQAQLDKALQKEKHYLQTTITKEA------YDALSRKSAACQDDLTQALEK 751
L + Q +L ++E + L+ T+ +EA + +K + ++L + LE+
Sbjct: 1148 LEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQ 1207
Query: 752 LNHV------------------TSETKSLQQSLTQTQEKK----AQLEEEIIAYEE---- 785
V +E K L Q ++ K+ AQL+E + + E
Sbjct: 1208 TKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERV 1267
Query: 786 ------RMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAK 839
++ KL EL + G +S+ + K + Q+ Q+ Q + + +
Sbjct: 1268 RTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSL 1327
Query: 840 EEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKV 899
+L++ ++E + +E L E+++ + ++ K L+ + +E +
Sbjct: 1328 STKLKQVEDEKNSFREQLEEEEE-----AKHNLEKQIATLHAQVADMKKKMEDSVGCLET 1382
Query: 900 ANEKLGNQLREQVKYIAKLSGEK----DHLHSVMVHLQQENKKLKKEIE---------EK 946
A E++ +L++ ++ +++ EK D L LQQE L +++ EK
Sbjct: 1383 A-EEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEK 1441
Query: 947 KMK------AENTRLCTK-ALGPSRTESTQREKVCGTLGW-KGLPQDMGQRMDLTK 994
K K AE + K A R E+ REK L + L + M Q+ +L +
Sbjct: 1442 KQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELER 1497
Score = 78.6 bits (192), Expect = 3e-14
Identities = 131/653 (20%), Positives = 280/653 (42%), Gaps = 115/653 (17%)
Query: 16 NSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEESEVEFGSS 75
N + LSL +K + D R+ L++ EEA ++ + + + + S
Sbjct: 1321 NRQKLSLSTKLKQVEDEKNSFREQLEEE----EEAKHNLEKQIATLHAQVADMKKKMEDS 1376
Query: 76 KQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLHHH---- 131
C L +++K+KL + L EE +Y L + ++ L+++ DL++ H
Sbjct: 1377 VGC-LETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQS 1435
Query: 132 -CKL----KEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQ 186
C L K+ + +L EE+ + E+ A+ + K SL R+L +
Sbjct: 1436 ACNLEKKQKKFDQLLAEEK--TISAKYAEERDRAEAEAREKETKALSLARAL-------E 1486
Query: 187 SSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVW 246
++ LE K + E+ +M +K D K + E +++++ L
Sbjct: 1487 EAMEQKAELERLNKQFRTEMEDLMS----SKDDVGK--------SVHELEKSKRALE--- 1531
Query: 247 QKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKK 306
Q+V + ++EL ++L + L E L ++A F R E+ E+ KK
Sbjct: 1532 QQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQF------ERDLQGRDEQSEEKKK 1585
Query: 307 IL--------KHLQEQKDSQCLHVEEYQNL---VKDLRVELEAVSEQKRNIMKDMMKLEL 355
L L++++ + + V + L +KDL +++ ++ + +K + KL+
Sbjct: 1586 QLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQA 1645
Query: 356 ----------DLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQE 405
D REE A + +K + ++ + +LQ E ++ K + QE
Sbjct: 1646 QMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERA---KRQAQQE 1702
Query: 406 KDEMLQE-----------LEKKLTQVQNSLLKKEKELEKQQC------------------ 436
+DE+ E LE+K +++ + + E+ELE++Q
Sbjct: 1703 RDELADEIANSSGKGALALEEK-RRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQ 1761
Query: 437 MATELEMTVKEAKQDKSK----EAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEE 492
+ T+L + A+++++ E + K L+ ++Q+++ +++ +K + + A +A + E
Sbjct: 1762 INTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVK-SKYKASITALEAKIAQLE 1820
Query: 493 AALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEEL 552
L ++ Q ++ +K+ D + ++ E + ++ A+K T R+++L
Sbjct: 1821 EQLDN-ETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKAST----RLKQL 1875
Query: 553 SLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKL 605
+L EA + + ++ +R+LQ+ ++ D + +RE S+K KL
Sbjct: 1876 KRQLEEAEEEAQRANASRRKLQR-------ELEDATETADAMNREVSSLKNKL 1921
Score = 58.2 bits (139), Expect = 4e-08
Identities = 105/558 (18%), Positives = 223/558 (39%), Gaps = 87/558 (15%)
Query: 9 DREVSSLNSKLLSLQLDIKNLHD-VCKRQRKTLQDNQLCMEEAMNSS-----HDKKQAQA 62
++ + L +L L +D+ + C ++K + +QL EE S+ D+ +A+A
Sbjct: 1412 EKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEA 1471
Query: 63 LAFEESEVEFGSSKQCHLRQ---LQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILE 119
E + + + + Q L++L K+ ++L +++ S + L + + LE
Sbjct: 1472 REKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALE 1531
Query: 120 KQTSDLVL----LHHHCKLKED-----EVIL------YEEEMGNHNENTGEKLHLAQEQL 164
+Q ++ L + ED EV L +E ++ +E + EK ++QL
Sbjct: 1532 QQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEK----KKQL 1587
Query: 165 ALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVR 224
++ +E L R + +++ + LE +K L+ + E K++
Sbjct: 1588 VR---QVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQ 1644
Query: 225 IYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADF 284
CM +E +T+ E+ + + + ++ + E +I+LQ +
Sbjct: 1645 AQMKDCM-RELDDTRASREEILAQAKENEKKLKSM--------------EAEMIQLQEEL 1689
Query: 285 ASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNL---VKDLRVELEAVSE 341
A+ R +E D + L +EE + L + L ELE
Sbjct: 1690 AAAERAKRQAQQERDELAD------EIANSSGKGALALEEKRRLEARIAQLEEELEEEQG 1743
Query: 342 ---------QKRNIMKDMMKLELDL---HGLREETSAH-IERKDKDITILQCRLQELQLE 388
+K N+ D + +L+L H + E + +ER++K++ + +LQE++
Sbjct: 1744 NTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKV---KLQEMEGT 1800
Query: 389 FTETQK--LTLKKDKFLQEKDEM-------------LQELEKKLTQVQNSLLKKEKELEK 433
K +T + K Q ++++ ++ EKKL V + + + E+
Sbjct: 1801 VKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQ 1860
Query: 434 QQCMATELEMTVKEAKQD-KSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEE 492
+ A + +K+ K+ + E E + A +KL+ LE+A + ++ + K +
Sbjct: 1861 YKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNK 1920
Query: 493 AALAGCHLEDTQRKLQKG 510
+R +KG
Sbjct: 1921 LRRGDLPFVVPRRMARKG 1938
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 129 bits (324), Expect = 1e-29
Identities = 221/1026 (21%), Positives = 424/1026 (41%), Gaps = 122/1026 (11%)
Query: 10 REVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEESE 69
REV L ++ L+ + L + + + + + EE +KQ L E E
Sbjct: 898 REVGELQGRVAQLEEERARLAEQLRAEAELCAE----AEETRGRLAARKQELELVVSELE 953
Query: 70 VEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLH 129
G ++C RQ+Q KK+L QELE H E + + L+ LEK T++ +
Sbjct: 954 ARVGEEEECS-RQMQTEKKRLQQHIQELEAHLEAEEGARQKLQ-----LEKVTTEAKM-- 1005
Query: 130 HHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLE---RSLNLYRDKYQ 186
K E++++L E++ N ++ L +++LA + A E +SLN R KY+
Sbjct: 1006 ---KKFEEDLLLLEDQ----NSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYE 1058
Query: 187 SSLSNIE-----------LLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEH 235
++++++E LE + L GE + Q E + ++R ++
Sbjct: 1059 ATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLG----RKE 1114
Query: 236 QETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPP 295
+E Q L+ + + L++ LR A AL +E L+++ + T +
Sbjct: 1115 EELQAALARAEDEGGARAQLLKSLREAQA---ALAEAQED----LESERVARTKAEKQRR 1167
Query: 296 SSSEECE----DIKKILKHLQEQKDSQCLHVEEYQNLVKDL----RVELEAVSEQKRNIM 347
EE E +++ L Q++ + +E L K L R+ AV E ++
Sbjct: 1168 DLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1227
Query: 348 KDMMKLELDLHGLREETSAHIERK---DKDITILQCRLQELQLEFTETQKLTLKKDKFLQ 404
+ + +L L R A + + + +++ L+ L LQ E ++ + + LQ
Sbjct: 1228 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ 1287
Query: 405 EKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEM-TVKEAKQDKSKEAEC----K 459
E + E+ + L + + ELE E E T++ +K+ S EA+ +
Sbjct: 1288 EVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQE 1347
Query: 460 ALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAAL---AGCHLEDTQRKLQKGLLLDKQ 516
LQ E + + E AA Q +EEAA AG L+ Q +L + ++
Sbjct: 1348 LLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEE 1407
Query: 517 KADTIQELQRELQMLQKESS-----MAEKEQTSNR--KRVEELSLELSEALRKLENSDKE 569
+A ++ + + +E+ +AEK +T +R + L EL +A LE +
Sbjct: 1408 EAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLE----Q 1463
Query: 570 KRQLQKTVAEQDMKMNDMLDRIKH------QHREQGSIKCKLEEDLQ-EATKLLEDKREQ 622
+RQL T+ ++ K + +L K + RE+ + + E T+ LE+++E
Sbjct: 1464 QRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEA 1523
Query: 623 LKKSKEHEKLMEGELEAL---RQEFKKKDKTLKENSRKLEEENENLRA---ELQCCSTQL 676
++ + + + ELEAL + + K L+ R E+ +LRA EL+ T
Sbjct: 1524 REELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAA 1583
Query: 677 ESSLNKYNTSQQVIQ-----DLNKEIALQKESLMSLQAQL-DKALQKEKHYLQTTITKEA 730
E + + + Q ++ DL +E L QL D +++++ Q T+ A
Sbjct: 1584 EDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAA 1643
Query: 731 -------YDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAY 783
+ L + A+ +A+++L + ++ K L + + +T+ + ++ +
Sbjct: 1644 RKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRES 1703
Query: 784 EERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQL 843
E+R+K L E+ +L+ S+ + +EM+ +V N AA E+
Sbjct: 1704 EKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEV-------ANGNLSKAAILEEK 1756
Query: 844 REFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEK 903
R+ + + L+E L E+ L D R + +T + E
Sbjct: 1757 RQLEGRLGQLEEELEEEQSNSELL------NDRYRKLLLQVESLTTELSAERSFSAKAES 1810
Query: 904 LGNQLREQVKYIAKLSGEKD---------HLHSVMVHLQQENKKLKKEIEEKKMKAENTR 954
QL Q++ + GE+D + ++ L Q ++L++E E+ + + R
Sbjct: 1811 GRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVR 1870
Query: 955 LCTKAL 960
K L
Sbjct: 1871 RAEKRL 1876
Score = 114 bits (285), Expect = 5e-25
Identities = 149/677 (22%), Positives = 288/677 (42%), Gaps = 86/677 (12%)
Query: 308 LKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAH 367
L+ +QE + V E Q V L E++R + + ++ E +L EET
Sbjct: 886 LQKVQELQQQSAREVGELQGRVAQL--------EEERARLAEQLRAEAELCAEAEETRGR 937
Query: 368 IERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKK 427
+ + +++ ++ L+ E E + + K LQ+ +QELE L + + K
Sbjct: 938 LAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQH---IQELEAHLEAEEGARQKL 994
Query: 428 EKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAA 487
+ E + + E + + SK ++ + L E + + S + A+++E++ +
Sbjct: 995 QLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKL-LEDRLAEFSSQAAEEEEKVKSLNKL 1053
Query: 488 QCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRK 547
+ K EA +A +ED RK +KG QEL++ + L ESS +++ ++
Sbjct: 1054 RLKYEATIA--DMEDRLRKEEKGR----------QELEKLKRRLDGESSELQEQMVEQQQ 1101
Query: 548 RVEELSL-------ELSEALRKLENSDKEKRQLQKTV---------AEQDMKMNDML-DR 590
R EEL EL AL + E+ + QL K++ A++D++ + +
Sbjct: 1102 RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK 1161
Query: 591 IKHQHREQG----SIKCKLEE--DLQEATKLLEDKREQ----LKKSKEHE-KLMEGELEA 639
+ Q R+ G +++ +LE+ D A + L KREQ LKK+ E E ++ E ++
Sbjct: 1162 AEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE 1221
Query: 640 LRQEFKKKDKTLKENSRKLEEEN------ENLRAELQCCSTQLESSLNKYNTSQQVIQDL 693
LRQ + + L E + +LE+ E R L+ ++L + L+ T++Q +
Sbjct: 1222 LRQ---RHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQR 1278
Query: 694 NKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLN 753
+ + LQ + + ++A + LQ A L S A L +A K
Sbjct: 1279 RRRLELQLQEVQGRAGDGERARAEAAEKLQ-----RAQAELENVSGA----LNEAESKTI 1329
Query: 754 HVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDK 813
++ E S + L QE + +A R++ + E LR +E +
Sbjct: 1330 RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGR 1389
Query: 814 KLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVP 873
+L+ Q+ +W+++ + + L A EE R E AL + L E
Sbjct: 1390 ELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEK------------T 1437
Query: 874 KDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQ 933
+ RL RG ++ L+ + + + ++Q K+ L+ EK + ++
Sbjct: 1438 ETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEK----AAVLRAV 1493
Query: 934 QENKKLKKEIEEKKMKA 950
+E ++ + E E++ +A
Sbjct: 1494 EERERAEAEGREREARA 1510
Score = 100 bits (249), Expect = 7e-21
Identities = 136/649 (20%), Positives = 273/649 (42%), Gaps = 105/649 (16%)
Query: 368 IERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKK 427
+ R+D+ +LQ R QELQ + E Q+ + ++ LQ + L+E +L + + +
Sbjct: 872 VTRQDE---VLQARAQELQ-KVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAEL 927
Query: 428 EKELEKQQ----CMATELEMTVKEAKQDKSKEAEC-KALQAEVQKLKNSLEEAKQQERLA 482
E E+ + ELE+ V E + +E EC + +Q E ++L+ ++E +
Sbjct: 928 CAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELE------ 981
Query: 483 AQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADT-IQELQRELQMLQKESSMAEKE 541
HLE + QK L L+K + +++ + +L +L+ ++S KE
Sbjct: 982 ---------------AHLEAEEGARQK-LQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKE 1025
Query: 542 QTSNRKRVEELSLELSEALRK---------------------LENSDKEKRQLQKTVAEQ 580
+ R+ E S + +E K L +K +++L+K
Sbjct: 1026 RKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRL 1085
Query: 581 DMKMNDMLDRIKHQHREQGSIKCKL---EEDLQEATKLLEDK---REQLKKS-KEHEKLM 633
D + +++ +++ Q + ++ +L EE+LQ A ED+ R QL KS +E + +
Sbjct: 1086 DGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAAL 1145
Query: 634 EGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDL 693
E L E + K K+ R L EE E LR E LE +L+ N Q++
Sbjct: 1146 AEAQEDLESERVARTKAEKQR-RDLGEELEALRGE-------LEDTLDSTNAQQELRSKR 1197
Query: 694 NKEIALQKESLMSLQAQLDKALQ--KEKHYLQTTITKEAYDALSRKSAACQDDLTQALEK 751
+E+ K++L + A+Q +++H E + R A + +
Sbjct: 1198 EQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAE 1257
Query: 752 LNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYE--------------ERMKKLNTELRKL 797
++ + +E SLQ + + ++++ +LE ++ + E++++ EL +
Sbjct: 1258 VSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENV 1317
Query: 798 RGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENL 857
G E+E + K+L Q+ Q+ Q + + A ++R + E A L+E L
Sbjct: 1318 SGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQL 1377
Query: 858 LEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQK------VANEKLGNQLREQ 911
E+ + ++ R R L +W ++Q+ A E+ + +
Sbjct: 1378 EEE----------AAARE--RAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAARE 1425
Query: 912 VKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKAL 960
+ + + EK + L++ ++L++E+++ M E R L
Sbjct: 1426 AEALTQRLAEKT---ETVDRLERGRRRLQQELDDATMDLEQQRQLVSTL 1471
Score = 95.1 bits (235), Expect = 3e-19
Identities = 154/791 (19%), Positives = 332/791 (41%), Gaps = 100/791 (12%)
Query: 9 DREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEES 68
+ EVS L ++L SLQ + +R+R LQ ++E + D ++A+A A E+
Sbjct: 1255 EAEVSELRAELSSLQTARQEGEQ--RRRRLELQ-----LQEVQGRAGDGERARAEAAEKL 1307
Query: 69 EVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLL 128
Q +L+ + L + + ++EL ++ L Q +L+++T + L
Sbjct: 1308 --------QRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLAL 1359
Query: 129 HHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSS 188
+ E E E++ E+ A+E+ AG ++ + + L+ +R + +
Sbjct: 1360 GSRVRAMEAEAAGLREQL--------EEEAAARER---AGRELQTAQAQLSEWRRRQEEE 1408
Query: 189 LSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQK 248
+E E E +E E + T + + + Q+ L +
Sbjct: 1409 AGALEAGE--------EARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMD 1460
Query: 249 VSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKIL 308
+ QQ L+ L K + L+ E + A+++ + A R E +
Sbjct: 1461 LEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGR------EREARALSLT 1514
Query: 309 KHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETS--- 365
+ L+E+++++ EE + + LR ELEA+ K ++ K + +LE + +
Sbjct: 1515 RALEEEQEAR----EELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLR 1570
Query: 366 AHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLL 425
A + + ++T + +L+LE T Q L + ++ LQ +DE +E ++L +
Sbjct: 1571 AQVTELEDELTAAEDA--KLRLEVT-VQALKTQHERDLQGRDEAGEERRRQLAKQL---- 1623
Query: 426 KKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQ 485
++ E+E+ + E KQ A K L+ E+++LK + A Q + A +Q
Sbjct: 1624 -RDAEVERDE-----------ERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQ 1671
Query: 486 AAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSN 545
+ + + +E+T+ ++ +++ ++ L+ E+ LQ+E + +++ +
Sbjct: 1672 LRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQA 1731
Query: 546 RKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKL 605
++ +E++ E++ +EKRQL+ + G ++ +L
Sbjct: 1732 QQDRDEMADEVANGNLSKAAILEEKRQLEGRL---------------------GQLEEEL 1770
Query: 606 EEDLQEATKLLEDKR-------EQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKL 658
EE+ Q ++LL D+ E L E+ + E+ RQ+ +++ ++E +L
Sbjct: 1771 EEE-QSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQ---IQELRGRL 1826
Query: 659 EEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKE 718
EE+ RA + LES L + +Q+ Q+ + I K + + + LQ E
Sbjct: 1827 GEEDAGARARHKMTIAALESKLAQ--AEEQLEQETRERILSGKLVRRAEKRLKEVVLQVE 1884
Query: 719 KHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEE 778
+ ++ + + + + L +A E+ + + + LQ+ L E +
Sbjct: 1885 EERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNR 1944
Query: 779 EIIAYEERMKK 789
E+ R+++
Sbjct: 1945 EVTTLRNRLRR 1955
Score = 52.4 bits (124), Expect = 2e-06
Identities = 96/485 (19%), Positives = 206/485 (42%), Gaps = 60/485 (12%)
Query: 503 TQRKLQKGLLLDKQKADT-IQELQRELQMLQKESS--------MAEKEQTSNRKRVEELS 553
T + KG + KQ + IQ L+ + + + S +A+ E+ + K + +
Sbjct: 757 TPNAIPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFRAGVLAQLEEERDLKVTDIIV 816
Query: 554 LELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQ--E 611
+ A L +KRQ Q++ + + +K +H + + K++ LQ
Sbjct: 817 SFQAAARGYLARRAFQKRQQQQSALR--VMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTR 874
Query: 612 ATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEEN----ENLRA 667
++L+ + ++L+K +E L+Q+ ++ L+ +LEEE E LRA
Sbjct: 875 QDEVLQARAQELQKVQE-----------LQQQSAREVGELQGRVAQLEEERARLAEQLRA 923
Query: 668 ELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTIT 727
E + C+ + E + + +Q ++ + E+ E+ + + + + +Q EK LQ I
Sbjct: 924 EAELCA-EAEETRGRLAARKQELELVVSEL----EARVGEEEECSRQMQTEKKRLQQHI- 977
Query: 728 KEAYDALSRKSAACQDDLTQALEKLNHVTSET---KSLQQSLTQTQEKKAQLEEEIIAYE 784
Q LE H+ +E + LQ T+ K + EE+++ E
Sbjct: 978 -------------------QELEA--HLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLE 1016
Query: 785 ERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLR 844
++ KL+ E + L E + ++K++ ++ L+++ D++ KEE+ R
Sbjct: 1017 DQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIA-DMEDRLRKEEKGR 1075
Query: 845 EFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKL 904
+ E++ + + +E Q + +L R +++ L + A+ + A +L
Sbjct: 1076 QELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALAR-AEDEGGARAQL 1134
Query: 905 GNQLREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSR 964
LRE +A+ + + +++ + L +E+E + + E+T T A R
Sbjct: 1135 LKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELR 1194
Query: 965 TESTQ 969
++ Q
Sbjct: 1195 SKREQ 1199
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 129 bits (324), Expect = 1e-29
Identities = 221/1026 (21%), Positives = 424/1026 (41%), Gaps = 122/1026 (11%)
Query: 10 REVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEESE 69
REV L ++ L+ + L + + + + + EE +KQ L E E
Sbjct: 890 REVGELQGRVAQLEEERARLAEQLRAEAELCAE----AEETRGRLAARKQELELVVSELE 945
Query: 70 VEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLH 129
G ++C RQ+Q KK+L QELE H E + + L+ LEK T++ +
Sbjct: 946 ARVGEEEECS-RQMQTEKKRLQQHIQELEAHLEAEEGARQKLQ-----LEKVTTEAKM-- 997
Query: 130 HHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLE---RSLNLYRDKYQ 186
K E++++L E++ N ++ L +++LA + A E +SLN R KY+
Sbjct: 998 ---KKFEEDLLLLEDQ----NSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYE 1050
Query: 187 SSLSNIE-----------LLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEH 235
++++++E LE + L GE + Q E + ++R ++
Sbjct: 1051 ATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLG----RKE 1106
Query: 236 QETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPP 295
+E Q L+ + + L++ LR A AL +E L+++ + T +
Sbjct: 1107 EELQAALARAEDEGGARAQLLKSLREAQA---ALAEAQED----LESERVARTKAEKQRR 1159
Query: 296 SSSEECE----DIKKILKHLQEQKDSQCLHVEEYQNLVKDL----RVELEAVSEQKRNIM 347
EE E +++ L Q++ + +E L K L R+ AV E ++
Sbjct: 1160 DLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1219
Query: 348 KDMMKLELDLHGLREETSAHIERK---DKDITILQCRLQELQLEFTETQKLTLKKDKFLQ 404
+ + +L L R A + + + +++ L+ L LQ E ++ + + LQ
Sbjct: 1220 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ 1279
Query: 405 EKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEM-TVKEAKQDKSKEAEC----K 459
E + E+ + L + + ELE E E T++ +K+ S EA+ +
Sbjct: 1280 EVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQE 1339
Query: 460 ALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAAL---AGCHLEDTQRKLQKGLLLDKQ 516
LQ E + + E AA Q +EEAA AG L+ Q +L + ++
Sbjct: 1340 LLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEE 1399
Query: 517 KADTIQELQRELQMLQKESS-----MAEKEQTSNR--KRVEELSLELSEALRKLENSDKE 569
+A ++ + + +E+ +AEK +T +R + L EL +A LE +
Sbjct: 1400 EAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLE----Q 1455
Query: 570 KRQLQKTVAEQDMKMNDMLDRIKH------QHREQGSIKCKLEEDLQ-EATKLLEDKREQ 622
+RQL T+ ++ K + +L K + RE+ + + E T+ LE+++E
Sbjct: 1456 QRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEA 1515
Query: 623 LKKSKEHEKLMEGELEAL---RQEFKKKDKTLKENSRKLEEENENLRA---ELQCCSTQL 676
++ + + + ELEAL + + K L+ R E+ +LRA EL+ T
Sbjct: 1516 REELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAA 1575
Query: 677 ESSLNKYNTSQQVIQ-----DLNKEIALQKESLMSLQAQL-DKALQKEKHYLQTTITKEA 730
E + + + Q ++ DL +E L QL D +++++ Q T+ A
Sbjct: 1576 EDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAA 1635
Query: 731 -------YDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAY 783
+ L + A+ +A+++L + ++ K L + + +T+ + ++ +
Sbjct: 1636 RKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRES 1695
Query: 784 EERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQL 843
E+R+K L E+ +L+ S+ + +EM+ +V N AA E+
Sbjct: 1696 EKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEV-------ANGNLSKAAILEEK 1748
Query: 844 REFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEK 903
R+ + + L+E L E+ L D R + +T + E
Sbjct: 1749 RQLEGRLGQLEEELEEEQSNSELL------NDRYRKLLLQVESLTTELSAERSFSAKAES 1802
Query: 904 LGNQLREQVKYIAKLSGEKD---------HLHSVMVHLQQENKKLKKEIEEKKMKAENTR 954
QL Q++ + GE+D + ++ L Q ++L++E E+ + + R
Sbjct: 1803 GRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVR 1862
Query: 955 LCTKAL 960
K L
Sbjct: 1863 RAEKRL 1868
Score = 114 bits (285), Expect = 5e-25
Identities = 149/677 (22%), Positives = 288/677 (42%), Gaps = 86/677 (12%)
Query: 308 LKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAH 367
L+ +QE + V E Q V L E++R + + ++ E +L EET
Sbjct: 878 LQKVQELQQQSAREVGELQGRVAQL--------EEERARLAEQLRAEAELCAEAEETRGR 929
Query: 368 IERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKK 427
+ + +++ ++ L+ E E + + K LQ+ +QELE L + + K
Sbjct: 930 LAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQH---IQELEAHLEAEEGARQKL 986
Query: 428 EKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAA 487
+ E + + E + + SK ++ + L E + + S + A+++E++ +
Sbjct: 987 QLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKL-LEDRLAEFSSQAAEEEEKVKSLNKL 1045
Query: 488 QCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRK 547
+ K EA +A +ED RK +KG QEL++ + L ESS +++ ++
Sbjct: 1046 RLKYEATIA--DMEDRLRKEEKGR----------QELEKLKRRLDGESSELQEQMVEQQQ 1093
Query: 548 RVEELSL-------ELSEALRKLENSDKEKRQLQKTV---------AEQDMKMNDML-DR 590
R EEL EL AL + E+ + QL K++ A++D++ + +
Sbjct: 1094 RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK 1153
Query: 591 IKHQHREQG----SIKCKLEE--DLQEATKLLEDKREQ----LKKSKEHE-KLMEGELEA 639
+ Q R+ G +++ +LE+ D A + L KREQ LKK+ E E ++ E ++
Sbjct: 1154 AEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE 1213
Query: 640 LRQEFKKKDKTLKENSRKLEEEN------ENLRAELQCCSTQLESSLNKYNTSQQVIQDL 693
LRQ + + L E + +LE+ E R L+ ++L + L+ T++Q +
Sbjct: 1214 LRQ---RHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQR 1270
Query: 694 NKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLN 753
+ + LQ + + ++A + LQ A L S A L +A K
Sbjct: 1271 RRRLELQLQEVQGRAGDGERARAEAAEKLQ-----RAQAELENVSGA----LNEAESKTI 1321
Query: 754 HVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDK 813
++ E S + L QE + +A R++ + E LR +E +
Sbjct: 1322 RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGR 1381
Query: 814 KLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVP 873
+L+ Q+ +W+++ + + L A EE R E AL + L E
Sbjct: 1382 ELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEK------------T 1429
Query: 874 KDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQ 933
+ RL RG ++ L+ + + + ++Q K+ L+ EK + ++
Sbjct: 1430 ETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEK----AAVLRAV 1485
Query: 934 QENKKLKKEIEEKKMKA 950
+E ++ + E E++ +A
Sbjct: 1486 EERERAEAEGREREARA 1502
Score = 100 bits (249), Expect = 7e-21
Identities = 136/649 (20%), Positives = 273/649 (42%), Gaps = 105/649 (16%)
Query: 368 IERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKK 427
+ R+D+ +LQ R QELQ + E Q+ + ++ LQ + L+E +L + + +
Sbjct: 864 VTRQDE---VLQARAQELQ-KVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAEL 919
Query: 428 EKELEKQQ----CMATELEMTVKEAKQDKSKEAEC-KALQAEVQKLKNSLEEAKQQERLA 482
E E+ + ELE+ V E + +E EC + +Q E ++L+ ++E +
Sbjct: 920 CAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELE------ 973
Query: 483 AQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADT-IQELQRELQMLQKESSMAEKE 541
HLE + QK L L+K + +++ + +L +L+ ++S KE
Sbjct: 974 ---------------AHLEAEEGARQK-LQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKE 1017
Query: 542 QTSNRKRVEELSLELSEALRK---------------------LENSDKEKRQLQKTVAEQ 580
+ R+ E S + +E K L +K +++L+K
Sbjct: 1018 RKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRL 1077
Query: 581 DMKMNDMLDRIKHQHREQGSIKCKL---EEDLQEATKLLEDK---REQLKKS-KEHEKLM 633
D + +++ +++ Q + ++ +L EE+LQ A ED+ R QL KS +E + +
Sbjct: 1078 DGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAAL 1137
Query: 634 EGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDL 693
E L E + K K+ R L EE E LR E LE +L+ N Q++
Sbjct: 1138 AEAQEDLESERVARTKAEKQR-RDLGEELEALRGE-------LEDTLDSTNAQQELRSKR 1189
Query: 694 NKEIALQKESLMSLQAQLDKALQ--KEKHYLQTTITKEAYDALSRKSAACQDDLTQALEK 751
+E+ K++L + A+Q +++H E + R A + +
Sbjct: 1190 EQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAE 1249
Query: 752 LNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYE--------------ERMKKLNTELRKL 797
++ + +E SLQ + + ++++ +LE ++ + E++++ EL +
Sbjct: 1250 VSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENV 1309
Query: 798 RGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENL 857
G E+E + K+L Q+ Q+ Q + + A ++R + E A L+E L
Sbjct: 1310 SGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQL 1369
Query: 858 LEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQK------VANEKLGNQLREQ 911
E+ + ++ R R L +W ++Q+ A E+ + +
Sbjct: 1370 EEE----------AAARE--RAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAARE 1417
Query: 912 VKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKAL 960
+ + + EK + L++ ++L++E+++ M E R L
Sbjct: 1418 AEALTQRLAEKT---ETVDRLERGRRRLQQELDDATMDLEQQRQLVSTL 1463
Score = 95.1 bits (235), Expect = 3e-19
Identities = 154/791 (19%), Positives = 332/791 (41%), Gaps = 100/791 (12%)
Query: 9 DREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEES 68
+ EVS L ++L SLQ + +R+R LQ ++E + D ++A+A A E+
Sbjct: 1247 EAEVSELRAELSSLQTARQEGEQ--RRRRLELQ-----LQEVQGRAGDGERARAEAAEKL 1299
Query: 69 EVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLL 128
Q +L+ + L + + ++EL ++ L Q +L+++T + L
Sbjct: 1300 --------QRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLAL 1351
Query: 129 HHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSS 188
+ E E E++ E+ A+E+ AG ++ + + L+ +R + +
Sbjct: 1352 GSRVRAMEAEAAGLREQL--------EEEAAARER---AGRELQTAQAQLSEWRRRQEEE 1400
Query: 189 LSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQK 248
+E E E +E E + T + + + Q+ L +
Sbjct: 1401 AGALEAGE--------EARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMD 1452
Query: 249 VSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKIL 308
+ QQ L+ L K + L+ E + A+++ + A R E +
Sbjct: 1453 LEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGR------EREARALSLT 1506
Query: 309 KHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETS--- 365
+ L+E+++++ EE + + LR ELEA+ K ++ K + +LE + +
Sbjct: 1507 RALEEEQEAR----EELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLR 1562
Query: 366 AHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLL 425
A + + ++T + +L+LE T Q L + ++ LQ +DE +E ++L +
Sbjct: 1563 AQVTELEDELTAAEDA--KLRLEVT-VQALKTQHERDLQGRDEAGEERRRQLAKQL---- 1615
Query: 426 KKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQ 485
++ E+E+ + E KQ A K L+ E+++LK + A Q + A +Q
Sbjct: 1616 -RDAEVERDE-----------ERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQ 1663
Query: 486 AAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSN 545
+ + + +E+T+ ++ +++ ++ L+ E+ LQ+E + +++ +
Sbjct: 1664 LRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQA 1723
Query: 546 RKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKL 605
++ +E++ E++ +EKRQL+ + G ++ +L
Sbjct: 1724 QQDRDEMADEVANGNLSKAAILEEKRQLEGRL---------------------GQLEEEL 1762
Query: 606 EEDLQEATKLLEDKR-------EQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKL 658
EE+ Q ++LL D+ E L E+ + E+ RQ+ +++ ++E +L
Sbjct: 1763 EEE-QSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQ---IQELRGRL 1818
Query: 659 EEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKE 718
EE+ RA + LES L + +Q+ Q+ + I K + + + LQ E
Sbjct: 1819 GEEDAGARARHKMTIAALESKLAQ--AEEQLEQETRERILSGKLVRRAEKRLKEVVLQVE 1876
Query: 719 KHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEE 778
+ ++ + + + + L +A E+ + + + LQ+ L E +
Sbjct: 1877 EERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNR 1936
Query: 779 EIIAYEERMKK 789
E+ R+++
Sbjct: 1937 EVTTLRNRLRR 1947
Score = 52.4 bits (124), Expect = 2e-06
Identities = 96/485 (19%), Positives = 206/485 (42%), Gaps = 60/485 (12%)
Query: 503 TQRKLQKGLLLDKQKADT-IQELQRELQMLQKESS--------MAEKEQTSNRKRVEELS 553
T + KG + KQ + IQ L+ + + + S +A+ E+ + K + +
Sbjct: 749 TPNAIPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFRAGVLAQLEEERDLKVTDIIV 808
Query: 554 LELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQ--E 611
+ A L +KRQ Q++ + + +K +H + + K++ LQ
Sbjct: 809 SFQAAARGYLARRAFQKRQQQQSALR--VMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTR 866
Query: 612 ATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEEN----ENLRA 667
++L+ + ++L+K +E L+Q+ ++ L+ +LEEE E LRA
Sbjct: 867 QDEVLQARAQELQKVQE-----------LQQQSAREVGELQGRVAQLEEERARLAEQLRA 915
Query: 668 ELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTIT 727
E + C+ + E + + +Q ++ + E+ E+ + + + + +Q EK LQ I
Sbjct: 916 EAELCA-EAEETRGRLAARKQELELVVSEL----EARVGEEEECSRQMQTEKKRLQQHI- 969
Query: 728 KEAYDALSRKSAACQDDLTQALEKLNHVTSET---KSLQQSLTQTQEKKAQLEEEIIAYE 784
Q LE H+ +E + LQ T+ K + EE+++ E
Sbjct: 970 -------------------QELEA--HLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLE 1008
Query: 785 ERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLR 844
++ KL+ E + L E + ++K++ ++ L+++ D++ KEE+ R
Sbjct: 1009 DQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIA-DMEDRLRKEEKGR 1067
Query: 845 EFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKL 904
+ E++ + + +E Q + +L R +++ L + A+ + A +L
Sbjct: 1068 QELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALAR-AEDEGGARAQL 1126
Query: 905 GNQLREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSR 964
LRE +A+ + + +++ + L +E+E + + E+T T A R
Sbjct: 1127 LKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELR 1186
Query: 965 TESTQ 969
++ Q
Sbjct: 1187 SKREQ 1191
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 129 bits (324), Expect = 1e-29
Identities = 221/1026 (21%), Positives = 424/1026 (41%), Gaps = 122/1026 (11%)
Query: 10 REVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEESE 69
REV L ++ L+ + L + + + + + EE +KQ L E E
Sbjct: 931 REVGELQGRVAQLEEERARLAEQLRAEAELCAE----AEETRGRLAARKQELELVVSELE 986
Query: 70 VEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLH 129
G ++C RQ+Q KK+L QELE H E + + L+ LEK T++ +
Sbjct: 987 ARVGEEEECS-RQMQTEKKRLQQHIQELEAHLEAEEGARQKLQ-----LEKVTTEAKM-- 1038
Query: 130 HHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLE---RSLNLYRDKYQ 186
K E++++L E++ N ++ L +++LA + A E +SLN R KY+
Sbjct: 1039 ---KKFEEDLLLLEDQ----NSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYE 1091
Query: 187 SSLSNIE-----------LLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEH 235
++++++E LE + L GE + Q E + ++R ++
Sbjct: 1092 ATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLG----RKE 1147
Query: 236 QETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPP 295
+E Q L+ + + L++ LR A AL +E L+++ + T +
Sbjct: 1148 EELQAALARAEDEGGARAQLLKSLREAQA---ALAEAQED----LESERVARTKAEKQRR 1200
Query: 296 SSSEECE----DIKKILKHLQEQKDSQCLHVEEYQNLVKDL----RVELEAVSEQKRNIM 347
EE E +++ L Q++ + +E L K L R+ AV E ++
Sbjct: 1201 DLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1260
Query: 348 KDMMKLELDLHGLREETSAHIERK---DKDITILQCRLQELQLEFTETQKLTLKKDKFLQ 404
+ + +L L R A + + + +++ L+ L LQ E ++ + + LQ
Sbjct: 1261 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ 1320
Query: 405 EKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEM-TVKEAKQDKSKEAEC----K 459
E + E+ + L + + ELE E E T++ +K+ S EA+ +
Sbjct: 1321 EVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQE 1380
Query: 460 ALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAAL---AGCHLEDTQRKLQKGLLLDKQ 516
LQ E + + E AA Q +EEAA AG L+ Q +L + ++
Sbjct: 1381 LLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEE 1440
Query: 517 KADTIQELQRELQMLQKESS-----MAEKEQTSNR--KRVEELSLELSEALRKLENSDKE 569
+A ++ + + +E+ +AEK +T +R + L EL +A LE +
Sbjct: 1441 EAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLE----Q 1496
Query: 570 KRQLQKTVAEQDMKMNDMLDRIKH------QHREQGSIKCKLEEDLQ-EATKLLEDKREQ 622
+RQL T+ ++ K + +L K + RE+ + + E T+ LE+++E
Sbjct: 1497 QRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEA 1556
Query: 623 LKKSKEHEKLMEGELEAL---RQEFKKKDKTLKENSRKLEEENENLRA---ELQCCSTQL 676
++ + + + ELEAL + + K L+ R E+ +LRA EL+ T
Sbjct: 1557 REELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAA 1616
Query: 677 ESSLNKYNTSQQVIQ-----DLNKEIALQKESLMSLQAQL-DKALQKEKHYLQTTITKEA 730
E + + + Q ++ DL +E L QL D +++++ Q T+ A
Sbjct: 1617 EDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAA 1676
Query: 731 -------YDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAY 783
+ L + A+ +A+++L + ++ K L + + +T+ + ++ +
Sbjct: 1677 RKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRES 1736
Query: 784 EERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQL 843
E+R+K L E+ +L+ S+ + +EM+ +V N AA E+
Sbjct: 1737 EKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEV-------ANGNLSKAAILEEK 1789
Query: 844 REFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEK 903
R+ + + L+E L E+ L D R + +T + E
Sbjct: 1790 RQLEGRLGQLEEELEEEQSNSELL------NDRYRKLLLQVESLTTELSAERSFSAKAES 1843
Query: 904 LGNQLREQVKYIAKLSGEKD---------HLHSVMVHLQQENKKLKKEIEEKKMKAENTR 954
QL Q++ + GE+D + ++ L Q ++L++E E+ + + R
Sbjct: 1844 GRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVR 1903
Query: 955 LCTKAL 960
K L
Sbjct: 1904 RAEKRL 1909
Score = 114 bits (285), Expect = 5e-25
Identities = 149/677 (22%), Positives = 288/677 (42%), Gaps = 86/677 (12%)
Query: 308 LKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAH 367
L+ +QE + V E Q V L E++R + + ++ E +L EET
Sbjct: 919 LQKVQELQQQSAREVGELQGRVAQL--------EEERARLAEQLRAEAELCAEAEETRGR 970
Query: 368 IERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKK 427
+ + +++ ++ L+ E E + + K LQ+ +QELE L + + K
Sbjct: 971 LAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQH---IQELEAHLEAEEGARQKL 1027
Query: 428 EKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAA 487
+ E + + E + + SK ++ + L E + + S + A+++E++ +
Sbjct: 1028 QLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKL-LEDRLAEFSSQAAEEEEKVKSLNKL 1086
Query: 488 QCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRK 547
+ K EA +A +ED RK +KG QEL++ + L ESS +++ ++
Sbjct: 1087 RLKYEATIA--DMEDRLRKEEKGR----------QELEKLKRRLDGESSELQEQMVEQQQ 1134
Query: 548 RVEELSL-------ELSEALRKLENSDKEKRQLQKTV---------AEQDMKMNDML-DR 590
R EEL EL AL + E+ + QL K++ A++D++ + +
Sbjct: 1135 RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK 1194
Query: 591 IKHQHREQG----SIKCKLEE--DLQEATKLLEDKREQ----LKKSKEHE-KLMEGELEA 639
+ Q R+ G +++ +LE+ D A + L KREQ LKK+ E E ++ E ++
Sbjct: 1195 AEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE 1254
Query: 640 LRQEFKKKDKTLKENSRKLEEEN------ENLRAELQCCSTQLESSLNKYNTSQQVIQDL 693
LRQ + + L E + +LE+ E R L+ ++L + L+ T++Q +
Sbjct: 1255 LRQ---RHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQR 1311
Query: 694 NKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLN 753
+ + LQ + + ++A + LQ A L S A L +A K
Sbjct: 1312 RRRLELQLQEVQGRAGDGERARAEAAEKLQ-----RAQAELENVSGA----LNEAESKTI 1362
Query: 754 HVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDK 813
++ E S + L QE + +A R++ + E LR +E +
Sbjct: 1363 RLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGR 1422
Query: 814 KLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVP 873
+L+ Q+ +W+++ + + L A EE R E AL + L E
Sbjct: 1423 ELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEK------------T 1470
Query: 874 KDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQ 933
+ RL RG ++ L+ + + + ++Q K+ L+ EK + ++
Sbjct: 1471 ETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEK----AAVLRAV 1526
Query: 934 QENKKLKKEIEEKKMKA 950
+E ++ + E E++ +A
Sbjct: 1527 EERERAEAEGREREARA 1543
Score = 100 bits (249), Expect = 7e-21
Identities = 136/649 (20%), Positives = 273/649 (42%), Gaps = 105/649 (16%)
Query: 368 IERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKK 427
+ R+D+ +LQ R QELQ + E Q+ + ++ LQ + L+E +L + + +
Sbjct: 905 VTRQDE---VLQARAQELQ-KVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAEL 960
Query: 428 EKELEKQQ----CMATELEMTVKEAKQDKSKEAEC-KALQAEVQKLKNSLEEAKQQERLA 482
E E+ + ELE+ V E + +E EC + +Q E ++L+ ++E +
Sbjct: 961 CAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELE------ 1014
Query: 483 AQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADT-IQELQRELQMLQKESSMAEKE 541
HLE + QK L L+K + +++ + +L +L+ ++S KE
Sbjct: 1015 ---------------AHLEAEEGARQK-LQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKE 1058
Query: 542 QTSNRKRVEELSLELSEALRK---------------------LENSDKEKRQLQKTVAEQ 580
+ R+ E S + +E K L +K +++L+K
Sbjct: 1059 RKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRL 1118
Query: 581 DMKMNDMLDRIKHQHREQGSIKCKL---EEDLQEATKLLEDK---REQLKKS-KEHEKLM 633
D + +++ +++ Q + ++ +L EE+LQ A ED+ R QL KS +E + +
Sbjct: 1119 DGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAAL 1178
Query: 634 EGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDL 693
E L E + K K+ R L EE E LR E LE +L+ N Q++
Sbjct: 1179 AEAQEDLESERVARTKAEKQR-RDLGEELEALRGE-------LEDTLDSTNAQQELRSKR 1230
Query: 694 NKEIALQKESLMSLQAQLDKALQ--KEKHYLQTTITKEAYDALSRKSAACQDDLTQALEK 751
+E+ K++L + A+Q +++H E + R A + +
Sbjct: 1231 EQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAE 1290
Query: 752 LNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYE--------------ERMKKLNTELRKL 797
++ + +E SLQ + + ++++ +LE ++ + E++++ EL +
Sbjct: 1291 VSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENV 1350
Query: 798 RGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENL 857
G E+E + K+L Q+ Q+ Q + + A ++R + E A L+E L
Sbjct: 1351 SGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQL 1410
Query: 858 LEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQK------VANEKLGNQLREQ 911
E+ + ++ R R L +W ++Q+ A E+ + +
Sbjct: 1411 EEE----------AAARE--RAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAARE 1458
Query: 912 VKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKAL 960
+ + + EK + L++ ++L++E+++ M E R L
Sbjct: 1459 AEALTQRLAEKT---ETVDRLERGRRRLQQELDDATMDLEQQRQLVSTL 1504
Score = 95.1 bits (235), Expect = 3e-19
Identities = 154/791 (19%), Positives = 332/791 (41%), Gaps = 100/791 (12%)
Query: 9 DREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEES 68
+ EVS L ++L SLQ + +R+R LQ ++E + D ++A+A A E+
Sbjct: 1288 EAEVSELRAELSSLQTARQEGEQ--RRRRLELQ-----LQEVQGRAGDGERARAEAAEKL 1340
Query: 69 EVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLL 128
Q +L+ + L + + ++EL ++ L Q +L+++T + L
Sbjct: 1341 --------QRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLAL 1392
Query: 129 HHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSS 188
+ E E E++ E+ A+E+ AG ++ + + L+ +R + +
Sbjct: 1393 GSRVRAMEAEAAGLREQL--------EEEAAARER---AGRELQTAQAQLSEWRRRQEEE 1441
Query: 189 LSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQK 248
+E E E +E E + T + + + Q+ L +
Sbjct: 1442 AGALEAGE--------EARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMD 1493
Query: 249 VSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKIL 308
+ QQ L+ L K + L+ E + A+++ + A R E +
Sbjct: 1494 LEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGR------EREARALSLT 1547
Query: 309 KHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETS--- 365
+ L+E+++++ EE + + LR ELEA+ K ++ K + +LE + +
Sbjct: 1548 RALEEEQEAR----EELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLR 1603
Query: 366 AHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLL 425
A + + ++T + +L+LE T Q L + ++ LQ +DE +E ++L +
Sbjct: 1604 AQVTELEDELTAAEDA--KLRLEVT-VQALKTQHERDLQGRDEAGEERRRQLAKQL---- 1656
Query: 426 KKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQ 485
++ E+E+ + E KQ A K L+ E+++LK + A Q + A +Q
Sbjct: 1657 -RDAEVERDE-----------ERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQ 1704
Query: 486 AAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSN 545
+ + + +E+T+ ++ +++ ++ L+ E+ LQ+E + +++ +
Sbjct: 1705 LRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQA 1764
Query: 546 RKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKL 605
++ +E++ E++ +EKRQL+ + G ++ +L
Sbjct: 1765 QQDRDEMADEVANGNLSKAAILEEKRQLEGRL---------------------GQLEEEL 1803
Query: 606 EEDLQEATKLLEDKR-------EQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKL 658
EE+ Q ++LL D+ E L E+ + E+ RQ+ +++ ++E +L
Sbjct: 1804 EEE-QSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQ---IQELRGRL 1859
Query: 659 EEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKE 718
EE+ RA + LES L + +Q+ Q+ + I K + + + LQ E
Sbjct: 1860 GEEDAGARARHKMTIAALESKLAQ--AEEQLEQETRERILSGKLVRRAEKRLKEVVLQVE 1917
Query: 719 KHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEE 778
+ ++ + + + + L +A E+ + + + LQ+ L E +
Sbjct: 1918 EERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNR 1977
Query: 779 EIIAYEERMKK 789
E+ R+++
Sbjct: 1978 EVTTLRNRLRR 1988
Score = 52.4 bits (124), Expect = 2e-06
Identities = 96/485 (19%), Positives = 206/485 (42%), Gaps = 60/485 (12%)
Query: 503 TQRKLQKGLLLDKQKADT-IQELQRELQMLQKESS--------MAEKEQTSNRKRVEELS 553
T + KG + KQ + IQ L+ + + + S +A+ E+ + K + +
Sbjct: 790 TPNAIPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFRAGVLAQLEEERDLKVTDIIV 849
Query: 554 LELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQ--E 611
+ A L +KRQ Q++ + + +K +H + + K++ LQ
Sbjct: 850 SFQAAARGYLARRAFQKRQQQQSALR--VMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTR 907
Query: 612 ATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEEN----ENLRA 667
++L+ + ++L+K +E L+Q+ ++ L+ +LEEE E LRA
Sbjct: 908 QDEVLQARAQELQKVQE-----------LQQQSAREVGELQGRVAQLEEERARLAEQLRA 956
Query: 668 ELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTIT 727
E + C+ + E + + +Q ++ + E+ E+ + + + + +Q EK LQ I
Sbjct: 957 EAELCA-EAEETRGRLAARKQELELVVSEL----EARVGEEEECSRQMQTEKKRLQQHI- 1010
Query: 728 KEAYDALSRKSAACQDDLTQALEKLNHVTSET---KSLQQSLTQTQEKKAQLEEEIIAYE 784
Q LE H+ +E + LQ T+ K + EE+++ E
Sbjct: 1011 -------------------QELEA--HLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLE 1049
Query: 785 ERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLR 844
++ KL+ E + L E + ++K++ ++ L+++ D++ KEE+ R
Sbjct: 1050 DQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIA-DMEDRLRKEEKGR 1108
Query: 845 EFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKL 904
+ E++ + + +E Q + +L R +++ L + A+ + A +L
Sbjct: 1109 QELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALAR-AEDEGGARAQL 1167
Query: 905 GNQLREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSR 964
LRE +A+ + + +++ + L +E+E + + E+T T A R
Sbjct: 1168 LKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELR 1227
Query: 965 TESTQ 969
++ Q
Sbjct: 1228 SKREQ 1232
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 129 bits (323), Expect = 2e-29
Identities = 229/1119 (20%), Positives = 463/1119 (41%), Gaps = 208/1119 (18%)
Query: 2 KDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKR--QRKTLQDNQLCMEEAMNSSHDKKQ 59
++E +D E+ + K ++ +++ + ++ + K + QL E + + ++ +
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910
Query: 60 AQALAFEESEVEFGSSKQCHLRQ-------LQQLKKKLLVLQQELEFHTEELQTSYYSLR 112
A+ A ++ E + + + LQ KKK+ Q+LE +E + + L+
Sbjct: 911 ARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQ 970
Query: 113 QYQSILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIA 172
LEK T++ + K E+E++L E++ N ++ L ++++A ++A
Sbjct: 971 -----LEKVTAEAKI-----KKMEEEILLLEDQ----NSKFIKEKKLMEDRIAECSSQLA 1016
Query: 173 SLE---RSLNLYRDKYQSSLSNIE------------------LLECQVKMLQGELGGIMG 211
E ++L R+K + +S++E L+ + LQ ++ +
Sbjct: 1017 EEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQA 1076
Query: 212 QEPENKGDHSKVRIYTSPCMIQEHQETQKR---LSEVWQKVSQQDDLIQELRNKLACSNA 268
Q E K +K + + ET + L V + +Q +L ++ ++ A N
Sbjct: 1077 QIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNK 1136
Query: 269 -------LVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLH 321
L E E +L+ + A +E ++KK L+ + ++Q
Sbjct: 1137 AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQD 1196
Query: 322 VEE-YQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLR------EETSAHIERKDKD 374
+ + + +++L +LE K N+ K+ LE D L ++ A E K K
Sbjct: 1197 MRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKK 1256
Query: 375 ITILQCRLQELQLEFTETQKLTL----KKDKFLQEKDE---MLQELEKK----------- 416
L ++QEL + +E +L + K K E D +L+E EKK
Sbjct: 1257 ---LDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASL 1313
Query: 417 LTQVQNS--LLKKE-----------KELEKQQCMATELEMTVKEAKQDKSKEAECKALQA 463
+Q+Q++ LL++E ++LE+++ E + +EA+ K+ E + ALQ+
Sbjct: 1314 ESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEAR--KNLEKQVLALQS 1371
Query: 464 EVQKLKN----------SLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLL- 512
++ K SLEEAK++ A+ +Q EE ALA LE T+ +LQ+ L
Sbjct: 1372 QLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDD 1431
Query: 513 ----LDKQK--ADTIQELQREL-QMLQKESSMAEK--------EQTSNRKRVEELSLE-- 555
LD Q+ A +++ Q++ Q+L +E S++ + E + K + LSL
Sbjct: 1432 LTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARA 1491
Query: 556 LSEAL----------------------------RKLENSDKEKRQLQKTVAEQDMKMNDM 587
L EAL + + +K KR L++ V E ++ ++
Sbjct: 1492 LEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEEL 1551
Query: 588 LDRIK-------HQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEAL 640
D ++ ++K + E DLQ + E+K+ L K ELEA
Sbjct: 1552 EDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVR-------ELEAE 1604
Query: 641 RQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQ 700
++ +K+ + +K+E + ++L A+++ + + + + Q ++D +E+
Sbjct: 1605 LEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEA 1664
Query: 701 KESLMSLQAQLDKALQKEKHYLQTTI--TKEAYDALSRKSAACQDDLTQALEKLNHVTSE 758
+ S + AQ K +K+ L+ I +E + R + + + +++ + S
Sbjct: 1665 RASRDEIFAQ-SKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASG 1723
Query: 759 TKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEM 818
+L + + + AQLEEE+ + M+ LN RK Q L ++
Sbjct: 1724 KSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTT--LQVDTLNAELAAERSAAQ 1781
Query: 819 SCQVLQWQKQHQNDLKMLAAKEEQLR-----EFQEEMAALKENLLEDDKEPCCLPQWSVP 873
+ Q + QN K L AK ++L +F+ ++AL+ +
Sbjct: 1782 KSDNARQQLERQN--KELKAKLQELEGAVKSKFKATISALEAKI---------------- 1823
Query: 874 KDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQ 933
Q+ LEQ AK++ AN+ + ++ + ++ E+ H ++
Sbjct: 1824 ----------GQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQME 1873
Query: 934 QEN---KKLKKEIEEKKMKAENTRLCTKALGPSRTESTQ 969
+ N K+LK+++EE + +A + L ++T+
Sbjct: 1874 KANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATE 1912
Score = 80.5 bits (197), Expect = 7e-15
Identities = 93/461 (20%), Positives = 189/461 (40%), Gaps = 40/461 (8%)
Query: 528 LQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDM 587
LQ+ ++E + K++ +V+E ++ L ++E ++ + + +AEQ ++
Sbjct: 845 LQVTRQEEELQAKDE--ELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETEL 902
Query: 588 LDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKK 647
+ + K +LEE L + +E++ E+ + + +K M+ ++ L ++
Sbjct: 903 FAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL--- 959
Query: 648 DKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLN----KEIALQKES 703
+E E R +LQ E+ + K +++D N KE L ++
Sbjct: 960 ------------DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDR 1007
Query: 704 LMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQ 763
+ +QL + +K K+ + +E + + ++ Q LEK + L
Sbjct: 1008 IAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAK------RKLD 1061
Query: 764 QSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVL 823
T Q++ A+L+ +I + ++ K EL+ + L + K + E+ Q+
Sbjct: 1062 GETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIA 1121
Query: 824 QWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPK---DTCRLY 880
+ Q+ +++ E+Q R+ EE+ ALK LED + Q K + L
Sbjct: 1122 ELQEDFESEKASRNKAEKQKRDLSEELEALKTE-LEDTLDTTAAQQELRTKREQEVAELK 1180
Query: 881 RGNDQIMTN----LEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQEN 936
+ ++ N ++ ++ A E+L QL + ++ A L K L + L E
Sbjct: 1181 KALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEV 1240
Query: 937 K-----KLKKEIEEKKMKAENTRLCTKALGPSRTESTQREK 972
K K + E + KK+ A+ L K R EK
Sbjct: 1241 KVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEK 1281
Score = 61.2 bits (147), Expect = 5e-09
Identities = 120/594 (20%), Positives = 232/594 (39%), Gaps = 71/594 (11%)
Query: 9 DREVSSLNSKLLSLQLDIKNLHDVCKR-QRKTLQDNQLCMEEAMNSSHDKKQAQALAFEE 67
++ + L +L L +D+ + V ++K + +QL EE S+ ++ E
Sbjct: 1419 EKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEA 1478
Query: 68 SEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVL 127
E K+ L + ++ L ++E E ++L+ L + + K +L
Sbjct: 1479 RE------KETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEK 1532
Query: 128 LHHHCKLKEDEVILYEEEMGNHNENTGE-KLHLAQEQLALAGDKIASLERSLNLYRDKYQ 186
+ + +E+ EE+ + + T + KL L A+ A ER L RD+
Sbjct: 1533 SKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMK----AQFERDLQT-RDEQN 1587
Query: 187 SSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKR---LS 243
LL QV+ L+ EL Q K+ I Q + R +
Sbjct: 1588 EEKKR--LLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIK 1645
Query: 244 EVWQKVSQQDDLIQELRNKLACSNALVL---EREKALIKLQADFASCTATHRYPPSSSEE 300
++ + +Q D +EL A + + E EK L L+A+ EE
Sbjct: 1646 QLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQL----------QEE 1695
Query: 301 CEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGL 360
++ +H ++++D E + + + A+ ++KR + + +LE +L
Sbjct: 1696 LASSERARRHAEQERD-------ELADEITNSASGKSALLDEKRRLEARIAQLEEEL--- 1745
Query: 361 REETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQV 420
EE +++E + ++ L E + K D Q+ + +EL+ KL ++
Sbjct: 1746 -EEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQEL 1804
Query: 421 QNSLLKKEKEL-----EKQQCMATELEMTVKEA----KQDKSKEAECKALQAEVQ----- 466
+ ++ K K K + +LE KE K + E + K + +V+
Sbjct: 1805 EGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRH 1864
Query: 467 --KLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQEL 524
+ K +E+A + + +Q + +EEA A ++RKLQ+ L + + L
Sbjct: 1865 ADQYKEQMEKANARMKQLKRQLEEAEEEATRANA----SRRKLQREL---DDATEANEGL 1917
Query: 525 QRELQMLQKE------SSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQ 572
RE+ L+ S + + +E SLELS+ + + SD + Q
Sbjct: 1918 SREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTESKTSDVNETQ 1971
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 129 bits (323), Expect = 2e-29
Identities = 169/775 (21%), Positives = 342/775 (44%), Gaps = 90/775 (11%)
Query: 232 IQEHQETQKRLSEVWQKVSQQ-------------DDLIQELRNKLACSNALVLEREKALI 278
I +H +++KR E W + S++ DDL+QE + L C L R
Sbjct: 1331 IMQHLKSKKR-EERWMRASKRQSEKEMEELHHNIDDLLQE-KKSLECE-VEELHRTVQKR 1387
Query: 279 KLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDS-QCLH---------VEEYQNL 328
+ Q DF S E E I+K LKH ++ D +C+ + E L
Sbjct: 1388 QQQKDFIDGNVE-----SLMTELE-IEKSLKHHEDIVDEIECIEKTLLKRRSELREADRL 1441
Query: 329 VKDLRVELEAVSEQKRNIM-------KDMMKLELDLHGLR---EETSAHIERKDKDITIL 378
+ + EL E+ +N + + +++ E D L +ET+ ++ + D+ + L
Sbjct: 1442 LAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSL 1501
Query: 379 QCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMA 438
Q ++L+ + +++ + +K + KD Q L KK ++ L K +K++E +
Sbjct: 1502 QADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNE 1561
Query: 439 TELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGC 498
+KE+ E +A +AE++KLK+ + +Q+ + +Q KEE L
Sbjct: 1562 DHHLQVLKES------EVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQG 1615
Query: 499 HLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKE---QTSNRKRVEELSLE 555
+ + LQ+ L L + + RE++ L +E S + E Q S RK +L+L
Sbjct: 1616 SMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKT--QLTLI 1673
Query: 556 LSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATK- 614
E ++ EN RQ+ K E + ++LD ++ ++ E +K + ++ + E K
Sbjct: 1674 KQEIEKEEENLQVVLRQMSKHKTE----LKNILDMLQLENHELQGLKLQHDQRVSELEKT 1729
Query: 615 ---LLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQC 671
+LE+K E L+ ++ + +GE+E +Q ++ + ++ ++ E+ L++ ++C
Sbjct: 1730 QVAVLEEKLE-LENLQQISQQQKGEIEWQKQLLERDKREIE----RMTAESRALQSCVEC 1784
Query: 672 CSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAY 731
S + E K + ++ + + +A +E+ Q+ L+K L+ LQ +
Sbjct: 1785 LSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEK-LELNVRKLQQEL----- 1838
Query: 732 DALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLN 791
D L+R + +D++ ++L SLQ+ L Q+ +++++ + L
Sbjct: 1839 DQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLL 1898
Query: 792 TELRKLRGFHQE--SELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEE 849
+E +L+ E + E +++ ++ QVLQ + +N LK L +E + Q+E
Sbjct: 1899 SEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQ-NEIEENKLK-LVQQEMMFQRLQKE 1956
Query: 850 MAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNL-------------EQWAKQ 896
+ +E+ LE K Q + K+ DQ+++ + E+W +
Sbjct: 1957 RES-EESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCES 2015
Query: 897 QKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAE 951
+ + QL E+ + + + SGE L ++ + L+ + ++ KAE
Sbjct: 2016 LEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAE 2070
Score = 123 bits (308), Expect = 1e-27
Identities = 181/786 (23%), Positives = 353/786 (44%), Gaps = 132/786 (16%)
Query: 230 CMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTA 289
C + EH + +VS+ +D++Q L++K +RE+ ++ A
Sbjct: 1313 CNVPEHHNLEN-------EVSRLEDIMQHLKSK---------KREERWMR---------A 1347
Query: 290 THRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKD 349
+ R S +E E++ + L ++K S VEE V+ + + + + N+
Sbjct: 1348 SKR---QSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDG---NVESL 1401
Query: 350 MMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEM 409
M +LE+ E++ H E +I ++ L + + E E +L + + L E
Sbjct: 1402 MTELEI------EKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEK 1455
Query: 410 LQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLK 469
+ +K T + SLL+ E + E+ + A E + + +A Q + ++LQA+ + L+
Sbjct: 1456 TKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQ------QLRSLQADAKDLE 1509
Query: 470 NSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQ 529
+ KQ+E L KE + D Q L K+K ++L ELQ
Sbjct: 1510 Q--HKIKQEEIL--------KEINKIVAAKDSDFQ-------CLSKKK----EKLTEELQ 1548
Query: 530 MLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMND-ML 588
LQK+ MAE+ + + + ++E SE L + + ++ EK + Q T +Q+M + D L
Sbjct: 1549 KLQKDIEMAERNEDHHLQVLKE-----SEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQL 1603
Query: 589 DRIKHQ-HREQGSIKCKLEEDLQEATKLLE-DKREQLKKSKEHEKLME------GELEAL 640
K + H QGS+ + + DLQEA +L E + E+ +E + L+E GEL
Sbjct: 1604 GHKKEELHLLQGSM-VQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQ 1662
Query: 641 RQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQ 700
E K + +K+ ++E+E ENL+ L+ ++K+ T + I D+ + L+
Sbjct: 1663 ISERKTQLTLIKQ---EIEKEEENLQVVLR--------QMSKHKTELKNILDM---LQLE 1708
Query: 701 KESLMSLQAQLDKALQK----EKHYLQTTITKEAYDALSRKSAACQDDLTQALEK----L 752
L L+ Q D+ + + + L+ + E +S++ + Q LE+ +
Sbjct: 1709 NHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREI 1768
Query: 753 NHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFD 812
+T+E+++LQ + ++K L+E+ +E KKL R L + S++E +
Sbjct: 1769 ERMTAESRALQSCVECLSKEKEDLQEKCDIWE---KKLAQTKRVLAAAEENSKMEQSNLE 1825
Query: 813 K------KLEEMSCQVLQWQKQHQNDL----KMLAAKEEQLREFQEEMAALKE--NLLED 860
K KL++ Q+ + + ND+ + L K E + QEE+A +++ NL +
Sbjct: 1826 KLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQ 1885
Query: 861 DKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEK---LGNQLRE-QVKYI- 915
D Q + + RL + + E K+++ ++ L N++ E ++K +
Sbjct: 1886 DLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQ 1945
Query: 916 ---------AKLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRTE 966
+ E+ L + V L+++ +L+KE+ ++K K + ++ +K L
Sbjct: 1946 QEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLD--QVLSKVLAAEERV 2003
Query: 967 STQREK 972
T +E+
Sbjct: 2004 RTLQEE 2009
Score = 113 bits (283), Expect = 8e-25
Identities = 182/800 (22%), Positives = 338/800 (42%), Gaps = 94/800 (11%)
Query: 11 EVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEESEV 70
E+ L S++ S Q ++ L +++ L Q M +A + AL E+EV
Sbjct: 1581 ELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQE-----ALRLGETEV 1635
Query: 71 EFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDL-VLLH 129
+ K H+R+++ L ++L + EL E +T ++Q +EK+ +L V+L
Sbjct: 1636 ---TEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQE---IEKEEENLQVVLR 1689
Query: 130 HHCKLKED-EVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSS 188
K K + + IL ++ NH E G KL Q L ++A LE L L + Q S
Sbjct: 1690 QMSKHKTELKNILDMLQLENH-ELQGLKLQHDQRVSELEKTQVAVLEEKLEL-ENLQQIS 1747
Query: 189 LSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQK 248
+E Q ++L+ + I E++ S V C+ +E ++ Q++ ++W
Sbjct: 1748 QQQKGEIEWQKQLLERDKREIERMTAESRALQSCVE-----CLSKEKEDLQEKC-DIW-- 1799
Query: 249 VSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECE-DIKKI 307
EK L + + A+ + S+ E+ E +++K+
Sbjct: 1800 -------------------------EKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKL 1834
Query: 308 LKHLQE-QKDSQCLH--VEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREET 364
+ L + +D LH + Q +++ R + ++ E+ N+ + + DL T
Sbjct: 1835 QQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLL----HT 1890
Query: 365 SAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSL 424
+ H + + T LQ + E F + QK K + LQ ++E + KL Q +
Sbjct: 1891 TKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMF 1950
Query: 425 LKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQ 484
+ +KE E ++ ++T+KE Q E E ++++ ++ + + A+++ R +
Sbjct: 1951 QRLQKERESEESKLETSKVTLKE--QQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQE 2008
Query: 485 QAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTS 544
+ C+ L T+R+L + +K+ + LQ+E ++ + S+ + +
Sbjct: 2009 EERWCESLEKT----LSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLT 2064
Query: 545 NRKRVEELSLELSEALR----KLENSDKEKRQ----LQKTVAEQDMKMNDMLDRIKHQHR 596
RK+ E+ L EAL+ +LE + E++Q +QK +A ++ D +R + +
Sbjct: 2065 ERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMK 2124
Query: 597 EQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSR 656
E ++ + E ++ + +R Q++ S L + +R K ++ L E
Sbjct: 2125 ELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPA 2184
Query: 657 KLE---EENENLRAELQCCSTQLESSLN------KYNTSQQVIQDLNKEIALQKESLM-- 705
LE E NENL EL+ L ++N K N SQ I D + +E L
Sbjct: 2185 DLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHR 2244
Query: 706 --SLQAQLDKALQKEKHYL-----QTTIT----KEAYDALSRKSAACQDDLTQALEKLNH 754
L+AQL + K+ L QT T + DAL + D +
Sbjct: 2245 EDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQL 2304
Query: 755 VTSETKSLQQSLTQTQEKKA 774
+S T+ Q L Q QEK A
Sbjct: 2305 ESSLTEDSQ--LGQNQEKNA 2322
Score = 108 bits (270), Expect = 3e-23
Identities = 173/864 (20%), Positives = 370/864 (42%), Gaps = 138/864 (15%)
Query: 2 KDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQ 61
+ +A E +R L+ +++L + K L+ +++ EE + K+ +
Sbjct: 1474 ESDAEELERRAQETAVNLVKADQQLRSL----QADAKDLEQHKIKQEEIL-----KEINK 1524
Query: 62 ALAFEESEVEFGSSKQCHL-RQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEK 120
+A ++S+ + S K+ L +LQ+L+K + + ++ + H + L+ S L+ ++ LEK
Sbjct: 1525 IVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEK 1584
Query: 121 QTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNL 180
S + ++ E+ + + ++G+ E +LHL Q + A A L+ +L L
Sbjct: 1585 LKSQVTS-------QQQEMAVLDRQLGHKKE----ELHLLQGSMVQAK---ADLQEALRL 1630
Query: 181 YRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQK 240
+ ++I ++ ++ L + G + Q E K + ++ QE ++ ++
Sbjct: 1631 GETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIK--------QEIEKEEE 1682
Query: 241 RLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEE 300
L V +++S+ ++ + + L N E +KLQ D +
Sbjct: 1683 NLQVVLRQMSKHKTELKNILDMLQLEN-----HELQGLKLQHD---------------QR 1722
Query: 301 CEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGL 360
+++K + E+K L +E Q + + + E+E + L
Sbjct: 1723 VSELEKTQVAVLEEK----LELENLQQISQQQKGEIEWQKQ------------------L 1760
Query: 361 REETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQV 420
E IER + LQ ++ L E K+D LQEK ++ EKKL Q
Sbjct: 1761 LERDKREIERMTAESRALQSCVECLSKE---------KED--LQEKCDIW---EKKLAQT 1806
Query: 421 QNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECK-ALQAEVQKLKNSLEEAKQQE 479
+ L E+ + +Q +LE+ V++ +Q+ + K +L ++ ++ L+E ++
Sbjct: 1807 KRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAV 1866
Query: 480 RLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAE 539
++ A ++ LA L T + + +LL +Q LQ+++ +
Sbjct: 1867 NSLQEELANVQDHLNLAKQDLLHTTK--HQDVLLSEQT-----RLQKDISEWANRFEDCQ 1919
Query: 540 KEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQG 599
KE+ + +++++ L E+ E KL + ++LQK ++ K+ +K Q +
Sbjct: 1920 KEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLE 1979
Query: 600 SIKCKLEEDLQEATKLLEDKREQLKKSKEHEK---LMEGELEALRQEFKKKDKTLKENSR 656
+ L + + E+++ +E E+ +E L +++ ++++ L E S
Sbjct: 1980 KELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSG 2039
Query: 657 K---LEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDK 713
+ L++E +++RA+ Q + K K++A KE+L ++QL+K
Sbjct: 2040 ELLALQKEADSMRADFSLLRNQFLTERKK----------AEKQVASLKEALKIQRSQLEK 2089
Query: 714 ALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKK 773
L ++K + I KE ++ QD+ E+ + E +Q T+ +++
Sbjct: 2090 NLLEQKQE-NSCIQKE----MATIELVAQDN----HERARRLMKELNQMQYEYTELKKQM 2140
Query: 774 AQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDL 833
A ++ E R +++ +R L+ E + E+ K L Q+ + DL
Sbjct: 2141 ANQKD----LERRQMEISDAMRTLK---SEVKDEIRTSLKNLN-------QFLPELPADL 2186
Query: 834 KMLAAKEEQLREFQEEMAALKENL 857
+ + + E L + E+ +LKENL
Sbjct: 2187 EAILERNENL---EGELESLKENL 2207
Score = 100 bits (248), Expect = 9e-21
Identities = 172/797 (21%), Positives = 331/797 (41%), Gaps = 152/797 (19%)
Query: 82 QLQQLKKKLLVLQQEL-EFHTEELQTSYYSLRQYQSILEKQTSDLVLLHHHCKLKEDEVI 140
QL+ +KK+ Q L E H E + LR + KQ + + L + +D +
Sbjct: 438 QLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEF--KQLEEAIQLKKISEAGKD--L 493
Query: 141 LYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVK 200
LY++ G +L L +K+ L L +K + ++ + ++K
Sbjct: 494 LYKQLSG--------RLQLV--------NKLRQEALDLELQMEKQKQEIAGKQK---EIK 534
Query: 201 MLQGELGGIMGQEPENKGDHSKVRIYTS------PCMIQEHQETQKRLSEVWQKVSQQDD 254
LQ + + ++P+ HS ++ S M +++Q+ + RL E+ +++++ +
Sbjct: 535 DLQIAIDSLDSKDPK----HSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETE 590
Query: 255 LIQELRNKL-----ACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILK 309
I++L +L A + AL + E + LQ + + EC +
Sbjct: 591 EIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQ---ATQAQNEC-------R 640
Query: 310 HLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIE 369
L+++K++ + E V+ R +LE V+ N+ K++ +LE L + E +A ++
Sbjct: 641 KLRDEKETLLQRLTE----VEQERDQLEIVAMDAENMRKELAELESALQE-QHEVNASLQ 695
Query: 370 RKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEK--KLTQVQNSLLKK 427
+ D++ + L+ +L L+ E +++ +ELEK +LTQ++ S L+
Sbjct: 696 QTQGDLSAYEAELEA---------RLNLRD----AEANQLKEELEKVTRLTQLEQSALQA 742
Query: 428 EKELEKQQCMATELEMTVKEAKQDKSKE--AECKALQAEVQKLKNSLEEAKQQERLAAQQ 485
E E E+Q + E K+ ++ E A+ K LQ + LK L++ +
Sbjct: 743 ELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDG 802
Query: 486 AAQCKEEAALAGCHLEDTQRKLQKGL----------LLDKQKADTIQELQREL-QMLQKE 534
+ +E AA +++ +RKL+ G +L K AD LQ++ ++L +
Sbjct: 803 LVRPEEVAA----RVDELRRKLKLGTGEMNIHSPSDVLGKSLAD----LQKQFSEILARS 854
Query: 535 SSMAEKEQTSNRKRVEELSLELSEAL-----------RKLE-NSDKEKRQLQKTVAEQDM 582
++ Q RK EE++L+ + R LE + +KRQ + + + +
Sbjct: 855 KWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMEN 914
Query: 583 KMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQ 642
+++ + + +K QG +L+E +E ++L RE KK K + + ++ L +
Sbjct: 915 EIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDK 974
Query: 643 EFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKE 702
E KK K + ++ +K T+ E+ + K+
Sbjct: 975 ELKKLKKAV--------------------------ATSDKLATA---------ELTIAKD 999
Query: 703 SLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQA------LEKLNHVT 756
L SL + K Q+ LQ + SRK+A DLT+A L+ L
Sbjct: 1000 QLKSLHGTVMKINQERAEELQEA------ERFSRKAAQAARDLTRAEAEIELLQNLLRQK 1053
Query: 757 SETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRG-FHQESELEVHAFDKKL 815
E L+ T EI E M++ TE+ +L+ F+ L
Sbjct: 1054 GEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVL 1113
Query: 816 EEMSCQVLQWQKQHQND 832
EE++ L+ + +QND
Sbjct: 1114 EEIA--ELRREVSYQND 1128
Score = 78.6 bits (192), Expect = 3e-14
Identities = 119/587 (20%), Positives = 254/587 (43%), Gaps = 96/587 (16%)
Query: 383 QELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELE 442
++L+ + ET++L K+ +FL+E + KL N LK+E L+KQ C + +
Sbjct: 277 RDLEKKMIETEELKSKQTRFLEEIKN-----QDKL----NKSLKEEAMLQKQSCEELKSD 327
Query: 443 MTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAA--------QQAAQCKEEAA 494
+ K K K E + +L+ L K + + + +E+
Sbjct: 328 LNTKNELL-KQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESP 386
Query: 495 LAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQM------------LQKESSMAEKEQ 542
G + ++D +A I++++ + Q+ L + EK+
Sbjct: 387 YIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKI 446
Query: 543 TSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDM-LDRIKHQHREQGSI 601
++ + R+ EL E+ +A +++ + +E +QL++ + Q K+++ D + Q + +
Sbjct: 447 SAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAI--QLKKISEAGKDLLYKQLSGRLQL 504
Query: 602 KCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEE 661
KL ++ + +E +++++ ++ K ++ +++L + K + S K E++
Sbjct: 505 VNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGK-EQQ 563
Query: 662 NENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHY 721
+ + + Q ++L+ L++ + I+DL +E L Q ++AL+K+
Sbjct: 564 LDIMNKQYQQLESRLDEILSRIAKETEEIKDL-------EEQLTEGQIAANEALKKD--- 613
Query: 722 LQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEII 781
L+ I+ L + TQA + + E ++L Q LT+ ++++ QLE I+
Sbjct: 614 LEGVIS-----GLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLE--IV 666
Query: 782 AYE-ERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKE 840
A + E M+K EL +L QE H + L++ + ++ + + L + A+
Sbjct: 667 AMDAENMRK---ELAELESALQEQ----HEVNASLQQTQGDLSAYEAELEARLNLRDAEA 719
Query: 841 EQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVA 900
QL+E E++ L T LEQ A Q ++
Sbjct: 720 NQLKEELEKVTRL----------------------------------TQLEQSALQAELE 745
Query: 901 NEK--LGNQLREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEE 945
E+ L N L + ++ + E LH+ + HLQ +N LK+++++
Sbjct: 746 KERQALKNALGK-AQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKD 791
Score = 67.4 bits (163), Expect = 6e-11
Identities = 130/618 (21%), Positives = 249/618 (40%), Gaps = 77/618 (12%)
Query: 9 DREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEES 68
+++ L S+L + I + K + L + Q+ EA+ + + + +
Sbjct: 568 NKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGT 627
Query: 69 EVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQT---SYYSLRQYQSILEKQTSDL 125
+ Q R+L+ K+ LL E+E ++L+ ++R+ + LE +
Sbjct: 628 IKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQ 687
Query: 126 VLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKY 185
++ + + ++ YE E+ +L+L + +++ + R L +
Sbjct: 688 HEVNASLQQTQGDLSAYEAELE-------ARLNLRDAEANQLKEELEKVTRLTQLEQSAL 740
Query: 186 QSSLSNIELLECQVKMLQGELGGIM---GQEPENKGDHSKVRIYTSP--CMIQEHQETQK 240
Q+ L E + + L+ LG +E EN H+K++ + Q+ ++ Q
Sbjct: 741 QAEL------EKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQN 794
Query: 241 RLSEVWQKVSQQDDL---IQELRNKLACSNALVLERE------KALIKLQADFASCTATH 291
L+ V + + +++ + ELR KL + K+L LQ F+ A
Sbjct: 795 HLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARS 854
Query: 292 RYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMM 351
++ ++ E + LQE+ L E+ ++ R E E + N K
Sbjct: 855 KWERDEAQVRE------RKLQEE---MALQQEKLATGQEEFRQACERALEARMNFDK--- 902
Query: 352 KLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQ 411
+ A I++ + +I LQ L+ ++ E Q LT D LQE DE
Sbjct: 903 ----------RQHEARIQQMENEIHYLQENLKSME----EIQGLT---DLQLQEADE--- 942
Query: 412 ELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQ-----DKSKEAE-------CK 459
E E+ L Q++ KK+ E K Q L+ +K+ K+ DK AE K
Sbjct: 943 EKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLK 1002
Query: 460 ALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKL-QKG--LLLDKQ 516
+L V K+ E Q+ +++AAQ + A +E Q L QKG L+ +
Sbjct: 1003 SLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEME 1062
Query: 517 KADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKT 576
K ++ ++K + E+++T + L L S+ EN +E +L++
Sbjct: 1063 KTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRRE 1122
Query: 577 VAEQDMKMNDMLDRIKHQ 594
V+ Q+ ++ M D K +
Sbjct: 1123 VSYQNDYISSMADPFKRR 1140
Score = 32.7 bits (73), Expect = 1.8
Identities = 65/336 (19%), Positives = 137/336 (40%), Gaps = 59/336 (17%)
Query: 633 MEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQD 692
+EG+ + + ++ E +LE + E E + ++ L + ++ +
Sbjct: 250 LEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKS 309
Query: 693 LNKEIALQKESLMSLQAQLD--KALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALE 750
L +E LQK+S L++ L+ L K+K T ++ Y+ L ++ A + D E
Sbjct: 310 LKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYE-LEQELAFYKIDAK--FE 366
Query: 751 KLNHVTSETKSLQQSLTQTQE-KKAQLEEEIIAYEE---------RMKKLNTELRKLRGF 800
LN+ SE + ++ ++ K++ + + A E ++KK+ + +LR
Sbjct: 367 PLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPD-EQLRND 425
Query: 801 HQESELEVHA-FDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLE 859
H L H D +LE+ K ++A + +L E +E+ ++ +L
Sbjct: 426 HMN--LRGHTPLDTQLEDKE--------------KKISAAQTRLSELHDEIEKAEQQILR 469
Query: 860 DDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVAN---EKLGNQLREQVKYIA 916
+E LE+ + +K++ + L QL +++ +
Sbjct: 470 ATEE-----------------------FKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVN 506
Query: 917 KLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAEN 952
KL E L M +QE +KEI++ ++ ++
Sbjct: 507 KLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDS 542
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 127 bits (319), Expect = 5e-29
Identities = 226/1065 (21%), Positives = 430/1065 (40%), Gaps = 163/1065 (15%)
Query: 16 NSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEESEVEFGSS 75
N+ L S D++ + +R ++D Q M N+ HD +Q
Sbjct: 495 NASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQ---------------- 538
Query: 76 KQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLHH-HCKL 134
Q+ L+ +L +Q E T +L+ S + QS+ + L L +L
Sbjct: 539 ------QMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRL 592
Query: 135 KEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIE- 193
+ + + +M G HL E ++L+ + RS+ + + + L IE
Sbjct: 593 QGEMAHIQVGQM----TQAGLLEHLKLENVSLSQQLTETQHRSMK-EKGRIAAQLQGIEA 647
Query: 194 -LLECQVKMLQGELGGIMGQEP------ENKGDHSKVRIYTSPCMIQEHQETQKRLSEVW 246
+L+ + +Q + M +E E +G+ +++ E Q Q +L+ +
Sbjct: 648 DMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLT-LL 706
Query: 247 QKVSQQDDLIQE---LRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECED 303
Q+ Q + L QE L +L + + RE++L LQ + A
Sbjct: 707 QRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQAR------------- 753
Query: 304 IKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREE 363
+ ++ ++D+ CL QN L L+A K + + +LE EE
Sbjct: 754 LGELQGEAASREDTICL----LQNEKIILEAALQAAKSGKEELDRGARRLEEGT----EE 805
Query: 364 TSAHIERKDKDITILQCRLQELQLEFTETQKLTLK-KDKFLQEK-------------DEM 409
TS +E+ +++ I +++ LQ E +K K K++FLQ+K D++
Sbjct: 806 TSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQL 865
Query: 410 LQELEKKLTQVQNSLLKKEKEL-----EKQQCMATELEMTVKEAKQDKSKEAECKALQAE 464
+ EL+ ++ + L + +EL EK+ A EL +E Q + A+ +
Sbjct: 866 ISELKATRKRLDSELKELRQELMQVHGEKRTAEA-ELSRLHREVAQVRQHMADLEGHLQS 924
Query: 465 VQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQEL 524
QK ++ +E Q + +Q E +E+ Q++ +K + KQK
Sbjct: 925 AQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQK------- 977
Query: 525 QRELQMLQKESSMAEKEQTSNRKRVEE----LSLELSEALRKLENSDKEKRQLQKTVAEQ 580
++ L + + A+KE + K E LS L EAL E +D E QL+
Sbjct: 978 ---MRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSS 1034
Query: 581 D--MKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELE 638
D + +++ + ++ + + K LE++LQE L ++L++S+E +E EL+
Sbjct: 1035 DSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTS---QELEESREKVLELEDELQ 1091
Query: 639 ALRQEFKKKDKTLKENSRKLEEENENLR----------AELQCCSTQLESSLNKYNTS-- 686
R F+KK K L+E+++KL E E+ + A L+ ++ LE++L K
Sbjct: 1092 ESRG-FRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLV 1150
Query: 687 ------QQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKS-A 739
Q V+Q +E K + +LQA L+K +K + + +R+
Sbjct: 1151 QLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFK 1210
Query: 740 ACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRG 799
A +L++ ++L + LQ Q ++ + +EI ++ + + +L+ L+
Sbjct: 1211 AASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQK 1270
Query: 800 FHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENL-- 857
E + ++++E + +V Q +++ Q+ + L E+Q R+ E + L +N+
Sbjct: 1271 QLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKS 1330
Query: 858 -LEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQ------------KVANEKL 904
LE +E + Q KD L ++ N++ +Q K E
Sbjct: 1331 ELEMAQEDLSMTQ----KDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRKEPK 1386
Query: 905 GNQ--------------------LREQVKYIAKLSGEK-DHLHSVMVHLQQENKKLKKEI 943
G L E ++ +S E +L+S + L+QE L++++
Sbjct: 1387 GEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQM 1446
Query: 944 EEKKMKAENTRLCTKALGPSRTESTQREKVCGTLGWKGLPQDMGQ 988
EE + + L P+ G G +G PQ Q
Sbjct: 1447 EEHALTVHESLSSWTPLEPATASPVPPG---GHAGPRGDPQRHSQ 1488
Score = 109 bits (273), Expect = 1e-23
Identities = 174/871 (19%), Positives = 367/871 (42%), Gaps = 135/871 (15%)
Query: 11 EVSSLNSKLLSLQLDIKNLHDV---CKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEE 67
E ++L SKL + Q +I +L V ++Q Q+ ++ ++ M + QA E
Sbjct: 553 ERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEH 612
Query: 68 SEVEFGS-SKQCHLRQLQQLKKK--LLVLQQELEFHTEELQTSYYSLRQYQSILE----K 120
++E S S+Q Q + +K+K + Q +E + + ++ +++ ++++E +
Sbjct: 613 LKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQR 672
Query: 121 QTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNL 180
+ + + D E+++ E L +QL + L + L L
Sbjct: 673 RLEEFEGERERLQRMADSAASLEQQL----EQVKLTLLQRDQQLEALQQEHLDLMKQLTL 728
Query: 181 YRDKYQSSLSNIELLECQVKMLQGELGGIMGQEP---------ENKGDHSKVRIYTSPCM 231
++ QS +++ L+ LQ LG + G+ +N+ + + +
Sbjct: 729 TQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSG 788
Query: 232 IQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALV--LEREKALIKLQADFAS--- 286
+E +RL E ++ S+ +++LR +LA + V L++E A +K Q
Sbjct: 789 KEELDRGARRLEEGTEETSET---LEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQF 845
Query: 287 ------CTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVS 340
A R S + ++K K L + +K+LR EL V
Sbjct: 846 LQQKVMVEAYRRDATSKDQLISELKATRKRLDSE--------------LKELRQELMQVH 891
Query: 341 EQKRNIMKDMMKLELDLHGLRE---ETSAHIERKDKDITILQCRLQELQLEFTETQKLT- 396
+KR ++ +L ++ +R+ + H++ K+ ++ LQ LQ + + +T
Sbjct: 892 GEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTE 951
Query: 397 ----LKKD---------KFLQEKDEMLQELEKKLTQVQNSLLKKEKELEK---------Q 434
LKK K + E+ + ++ L LT Q + K K E Q
Sbjct: 952 ANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQ 1011
Query: 435 QCMAT----ELEMTVKEAKQDKSKEA-----ECKALQAEVQKLKNS--LEEAKQQERLA- 482
+ +A + E+ A+ S + +AL+AE+Q + +S L E + QE +A
Sbjct: 1012 EALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIAL 1071
Query: 483 -AQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQREL----------QML 531
+Q+ + +E+ L++++ +K L++ EL+ E L
Sbjct: 1072 TSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAAL 1131
Query: 532 QKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQL----QKTVAEQDMKMNDM 587
++ +S+ E + +L+L++ L++ E D++ + L Q ++ ++ K+N +
Sbjct: 1132 REHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSL 1191
Query: 588 LDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKK 647
+++ E G + + A+ L + +++L+ +KEH + +L+A + + +
Sbjct: 1192 KEQVAAAKVEAGHNR----RHFKAASLELSEVKKELQ-AKEH---LVQKLQAEADDLQIR 1243
Query: 648 DKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSL 707
+ + + + E RA+LQ QL+ L+K Q +++L E+ ++ + SL
Sbjct: 1244 EGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSL 1303
Query: 708 QAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLT 767
+ QLD Q+ + L + L Q L+ +V SE + Q+ L+
Sbjct: 1304 KQQLDLTEQQGRKEL--------------------EGLQQLLQ---NVKSELEMAQEDLS 1340
Query: 768 QTQEKKAQLEEEIIAYEERMKKLNTELRKLR 798
TQ+ K L+ ++ + MK L + ++L+
Sbjct: 1341 MTQKDKFMLQAKVSELKNNMKTLLQQNQQLK 1371
Score = 98.6 bits (244), Expect = 3e-20
Identities = 170/815 (20%), Positives = 348/815 (42%), Gaps = 146/815 (17%)
Query: 211 GQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALV 270
GQE + + I +S + ETQ+ + +V ++ + + ++ L L S AL
Sbjct: 376 GQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEAL--SLEASQAL- 432
Query: 271 LEREKALI---------KLQADFASCTATHRYPPSSSEE-------CEDIKKILKHLQEQ 314
+EKA + KLQA ++ + S S E C D+++ + LQ
Sbjct: 433 --KEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNM 490
Query: 315 KDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSA---HIERK 371
+++ + N ++ + + + + ++ + M+ + +H LR++ +A +++
Sbjct: 491 LEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQV 550
Query: 372 DKDITILQCRLQELQLEFTETQ--------KLTLKKDKFLQEKDEMLQ------------ 411
+ T L +L+ Q E + Q +L L ++ ++ + EM
Sbjct: 551 QLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLL 610
Query: 412 --------ELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAEC----- 458
L ++LT+ Q+ +K EK Q E +M +EA + +EA+
Sbjct: 611 EHLKLENVSLSQQLTETQHRSMK-EKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEED 669
Query: 459 -----KALQAEVQKLKN------SLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKL 507
+ + E ++L+ SLE+ +Q +L Q Q E AL HL D ++L
Sbjct: 670 LQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLE--ALQQEHL-DLMKQL 726
Query: 508 ---QKGLLLDKQKADTIQ----ELQRELQMLQKESSMAEKEQTSNRKRVEELSLE--LSE 558
Q+ L +Q D +Q ELQ L LQ E+ A +E T + E++ LE L
Sbjct: 727 TLTQEALQSREQSLDALQTHYDELQARLGELQGEA--ASREDTICLLQNEKIILEAALQA 784
Query: 559 ALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLED 618
A E D+ R+L++ E ++ L+++ RE+ +IK E LQ+ T L+
Sbjct: 785 AKSGKEELDRGARRLEEGTEET----SETLEKL----REELAIKSGQVEHLQQETAALKK 836
Query: 619 KREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLES 678
+ +++K+ +K+M +EA R++ KD+ + E L+ + L +EL+ +L
Sbjct: 837 QMQKIKEQFLQQKVM---VEAYRRDATSKDQLISE----LKATRKRLDSELKELRQELMQ 889
Query: 679 SLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKS 738
+ T++ + L++E+A ++ + L+ L A QKE+ ++T + +D
Sbjct: 890 VHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSA-QKERDEMETHLQSLQFDK----- 943
Query: 739 AACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTEL---- 794
E++ VT ++L++ + + Q+ + + I +++M++L ++L
Sbjct: 944 -----------EQMVAVTEANEALKKQIEELQQ---EARKAITEQKQKMRRLGSDLTSAQ 989
Query: 795 RKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALK 854
++++ H+ E V ++L+E + + L+ + E + AL+
Sbjct: 990 KEMKTKHKAYENAVGILSRRLQE-ALAAKEAADAELGQLRAQGGSSDSSLALHERIQALE 1048
Query: 855 ENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKY 914
L +V L + +++ Q ++ + +L ++L+E +
Sbjct: 1049 AELQ------------AVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGF 1096
Query: 915 IAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMK 949
K+ L++ NKKL E+E +K K
Sbjct: 1097 RKKIK-----------RLEESNKKLALELEHEKGK 1120
Score = 97.4 bits (241), Expect = 6e-20
Identities = 141/667 (21%), Positives = 275/667 (41%), Gaps = 79/667 (11%)
Query: 296 SSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLEL 355
+++E + +++ ++ ++DS C V L E+ ++K+ M+LE
Sbjct: 368 AAAEHQDQGQEVNGEVRSRRDSICSSVS--------LESSAAETQEEMLQVLKEKMRLEG 419
Query: 356 DLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQ---E 412
L L E S ++ K + L +LQ + + ++D E D + Q +
Sbjct: 420 QLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWD 479
Query: 413 LEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSL 472
LE+ +T +QN L K L ++ ++ V E +Q + A+ + +Q + N++
Sbjct: 480 LERAMTDLQNMLEAKNASLA-----SSNNDLQVAE-EQYQRLMAKVEDMQRSMLSKDNTV 533
Query: 473 EEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQ 532
+ +QQ Q Q + E L+ +Q ++ + + + Q LQ
Sbjct: 534 HDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQ 593
Query: 533 KESSMAEKEQTSNRKRVEELSLE-LSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRI 591
E + + Q + +E L LE +S + + E + ++ + A+ DMLD+
Sbjct: 594 GEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQ- 652
Query: 592 KHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTL 651
+ + K +EEDLQ + E +RE+L++ + +E +LE ++ ++D+ L
Sbjct: 653 EAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQL 712
Query: 652 KENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQL 711
+ QQ DL K++ L +E+L S + L
Sbjct: 713 E--------------------------------ALQQEHLDLMKQLTLTQEALQSREQSL 740
Query: 712 DKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQE 771
D ALQ LQ + + +A SR+ C + + L KS ++ L +
Sbjct: 741 D-ALQTHYDELQARLGELQGEAASREDTICLLQNEKII--LEAALQAAKSGKEELDRGAR 797
Query: 772 KKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQN 831
+ LEE E ++KL EL G + + E A K+++++ Q LQ QK
Sbjct: 798 R---LEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQ-QKVMVE 853
Query: 832 DLKMLAAKEEQL--------REFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGN 883
+ A ++QL + E+ L++ L++ E + + + RL+R
Sbjct: 854 AYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGE-----KRTAEAELSRLHREV 908
Query: 884 DQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEI 943
Q+ ++ + A ++ E ++ L +K+ MV + + N+ LKK+I
Sbjct: 909 AQVRQHMADLEGHLQSAQKERD----EMETHLQSLQFDKEQ----MVAVTEANEALKKQI 960
Query: 944 EEKKMKA 950
EE + +A
Sbjct: 961 EELQQEA 967
Score = 79.7 bits (195), Expect = 1e-14
Identities = 93/476 (19%), Positives = 211/476 (44%), Gaps = 76/476 (15%)
Query: 532 QKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRI 591
Q+E KE+ ++E LSLE S+AL KEK +LQ +A K+ ++
Sbjct: 404 QEEMLQVLKEKMRLEGQLEALSLEASQAL-------KEKAELQAQLAALSTKLQAQVECS 456
Query: 592 KHQHREQGSIKCK----------LEEDLQEATKLLEDKREQLKKS--------KEHEKLM 633
+ Q S+ + LE + + +LE K L S +++++LM
Sbjct: 457 HSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLM 516
Query: 634 EGELEALRQEFKKKDKT---LKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVI 690
++E +++ KD T L++ L+ + + ++ E +++L++S + ++ Q V
Sbjct: 517 -AKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVR 575
Query: 691 QDLNKEIALQKESLMSLQAQLD-------------KALQKEKHYLQTTITKEAYDALSRK 737
Q +++AL +E+ + LQ ++ + L+ E L +T+ + ++ K
Sbjct: 576 QWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEK 635
Query: 738 SAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKL 797
+ +L + ++ + + Q QE K +EE++ + R+++ E +L
Sbjct: 636 G--------RIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDL---QRRLEEFEGERERL 684
Query: 798 RGFHQESELEVHAFDKKLEEMSCQVLQ-------WQKQHQNDLKMLAAKEEQLREFQEEM 850
+ + + +++LE++ +LQ Q++H + +K L +E L+ ++ +
Sbjct: 685 QRMADSAA----SLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSL 740
Query: 851 AALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTN------------LEQWAKQQK 898
AL+ + E L + ++ N++I+ L++ A++ +
Sbjct: 741 DALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLE 800
Query: 899 VANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAENTR 954
E+ L + + +A SG+ +HL L+++ +K+K++ ++K+ E R
Sbjct: 801 EGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYR 856
Score = 60.5 bits (145), Expect = 8e-09
Identities = 104/520 (20%), Positives = 205/520 (39%), Gaps = 95/520 (18%)
Query: 385 LQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLT-QVQNSLLKKEKELEKQQCMATELEM 443
L L ETQ + L++++++ + K L Q++ +K+++E Q T L
Sbjct: 126 LSLPMQETQLCSTDSPLPLEKEEQVRLQARKWLEEQLKQYRVKRQQERSSQPATKTRLFS 185
Query: 444 TVKEA---KQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAA------QQAAQCKEEAA 494
T+ + A A+ E L+ S+ + L ++ ++ + +
Sbjct: 186 TLDPELMLNPENLPRASTLAMTKEYSFLRTSVPRGPKVGSLGLPAHPREKKTSKSSKIRS 245
Query: 495 LAGCHLEDTQRKLQKGLLL--DKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEEL 552
LA ED+ G + D K Q ++ + S + + R+E
Sbjct: 246 LADYRTEDSNAGNSGGNVPAPDSTKGSLKQNRSSAASVVSEISLSPDTDD-----RLENT 300
Query: 553 SLELSEALRKLENSDKEKRQ------------LQKTVAEQDM------------------ 582
SL +++ +++ +D + L KTV QD
Sbjct: 301 SLA-GDSVSEVDGNDSDSSSYSSASTRGTYGILSKTVGTQDTPYMVNGQEIPADTLGQFP 359
Query: 583 KMNDMLDRIKHQHREQG--------SIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLME 634
+ D+L +H++QG S + + + + E + E L+ KE +L E
Sbjct: 360 SIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRL-E 418
Query: 635 GELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLN 694
G+LEAL E S+ L+E+ E L+A+L ST+L++ + ++SQQ L+
Sbjct: 419 GQLEALS----------LEASQALKEKAE-LQAQLAALSTKLQAQVECSHSSQQRQDSLS 467
Query: 695 KEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNH 754
E+ K+S L+ + T + +A + A+ +DL A E+
Sbjct: 468 SEVDTLKQSCWDLERAM-------------TDLQNMLEAKNASLASSNNDLQVAEEQYQR 514
Query: 755 VTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKK 814
+ ++ + +Q+S+ L +++ A + +++++ E L + S+ E+ +
Sbjct: 515 LMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQ-- 572
Query: 815 LEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALK 854
V QW +Q LA +E Q EMA ++
Sbjct: 573 ------SVRQWYQQ------QLALAQEARVRLQGEMAHIQ 600
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 126 bits (317), Expect = 9e-29
Identities = 231/1017 (22%), Positives = 438/1017 (43%), Gaps = 130/1017 (12%)
Query: 29 LHDVCKRQRKTLQDNQLC---------MEEAMNSS--HDKKQAQALAFEES----EVEFG 73
L ++ K QDNQ+C +E+ +N H + + L + S EV +
Sbjct: 299 LENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYM 358
Query: 74 SSKQCHLRQ-LQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLH--- 129
++ + L Q +K + +++LEF EL + + ++EK S+L L+
Sbjct: 359 NNLKLKLEMDAQHIKDEFFHEREDLEFKINEL---LLAKEEQGCVIEKLKSELAGLNKQF 415
Query: 130 -----HHCKLKEDEVILYEEEMGNHNE---NTGEKLHLAQEQLALAGDKIASLERSLNLY 181
H + + +++E+ NE + EK E+L L + E+ NL
Sbjct: 416 CYTVEQHNREVQSLKEQHQKEISELNETFLSDSEK-----EKLTLMFEIQGLKEQCENLQ 470
Query: 182 RDKYQSSLSNIELLECQVKMLQGELG---GIMGQEPENKGDHS-------KVRIYTSPCM 231
++K Q ++ N E L +++LQ ELG G + QE E+ + ++ T+
Sbjct: 471 QEK-QEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTE 529
Query: 232 IQEHQETQKRLSEVWQKVSQQDDLIQELRN---KLACSNALVL----EREKALIKLQADF 284
ET RL +K+ Q +L+ EL N L N + L +R+ L +L+
Sbjct: 530 KDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKI 589
Query: 285 ASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKR 344
S T EE +D LK+ E+ D+ E + L+ +L ++E +
Sbjct: 590 NSLT----------EEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNS 639
Query: 345 NIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQ 404
+ + + +L L +E + ++ +K + ++ ++ ++ E + L + +K
Sbjct: 640 ELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSS 699
Query: 405 EKDEMLQELEKKLTQVQNSLLKKE-KELEKQQCMATELEMTVKEAKQDKSKEAECKALQA 463
EK ++ ++LE L+Q ++ +LK+ +LEK +L++ V+E QD K L+
Sbjct: 700 EKKQLSRDLEVFLSQKEDVILKEHITQLEK------KLQLMVEE--QDNLN----KLLEN 747
Query: 464 E-VQKL--KNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADT 520
E VQKL K L ++ + ++ K+ + E + ++ L Q+ +
Sbjct: 748 EQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEK 807
Query: 521 IQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQ 580
+ EL++E++ LQ+ES + +E S + E+ + L ++LE EK LQ + E
Sbjct: 808 VLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLR---KELEEIQSEKEALQSDLLE- 863
Query: 581 DMKMNDMLDRIKHQHR----EQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLME-- 634
MK + R+++Q+ E+ S C E E K + E LK E ++L +
Sbjct: 864 -MKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRR 922
Query: 635 GELEALRQEFKKKDKTLKE---NSRKLEEENENLRAELQCCSTQLESSLNKYN----TSQ 687
EL L+ K + + ++LEE+ ENL E + + E +NK ++
Sbjct: 923 AELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECK----EKEEKINKIKLVAVKAK 978
Query: 688 QVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQ 747
+ + KE KE L SL+++ D+ + +Q E+Y L + + L
Sbjct: 979 KELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGA---ESYKNLLLEYEKQSEQLDV 1035
Query: 748 ALEKLNH----VTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQE 803
E+ N+ + T+ L+ S Q + + E+++A R++ L + + L E
Sbjct: 1036 EKERANNFEHRIEDLTRQLRNSTLQCETINSD-NEDLLA---RIETLQSNAKLLEVQILE 1091
Query: 804 SELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKE--NLLEDD 861
+ DK+LE Q Q K+H + L + QL++ ++++ + L++ D
Sbjct: 1092 VQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKD 1151
Query: 862 KEPCCLPQWSVPKDTCRLYRGNDQIMTN-------LEQWAKQQKVANEKLGNQLREQVKY 914
+ L + D RL + +Q +TN LEQ K QK E L ++
Sbjct: 1152 AQQTTLMNMEI-ADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSS 1210
Query: 915 IAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRTESTQRE 971
+ + + + ++V K KKE+ + K +AE L +A E++Q++
Sbjct: 1211 VQQYEEKNTKIKQLLV-------KTKKELADSK-QAETDHLILQASLKGELEASQQQ 1259
Score = 112 bits (281), Expect = 1e-24
Identities = 214/1053 (20%), Positives = 436/1053 (41%), Gaps = 157/1053 (14%)
Query: 17 SKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAM--NSSHDKKQAQALAFEESEVEFGS 74
+KL + ++ N H C+R+ + + + +E+ + NS ++K + E ++
Sbjct: 601 NKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLK--- 657
Query: 75 SKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDL--------- 125
K + ++L++L ++ VL ++ E + E+++ Y + S ++ + DL
Sbjct: 658 EKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKED 717
Query: 126 VLLHHHCKLKEDEVILYEEEMGNHN---ENTGEKLHLAQEQL----ALAGDKIA--SLER 176
V+L H E ++ L EE N N EN + + QL G +++ S E+
Sbjct: 718 VILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEK 777
Query: 177 SLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQ 236
+ SL+ I +C + + E + +E + + S V+ ++++++
Sbjct: 778 DVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYE 837
Query: 237 ETQKRLSEVWQKVSQQDDLIQ-ELRNKLACSNALVLEREKALIKLQADFASCTATHRYPP 295
+ + L + +++ + + +Q +L + LE + LI+++ +C+ + +
Sbjct: 838 QEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIH-- 895
Query: 296 SSSEECEDIKKI--LKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKL 353
+ E+C IK+ LK L EQK+ + E L+KD + +V K + + + +L
Sbjct: 896 NEKEKCF-IKEHENLKPLLEQKELRDRRAELI--LLKDSLAKSPSV---KNDPLSSVKEL 949
Query: 354 ELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEM---L 410
E + L +E E+ +K + +EL ETQ + + + EKD++ +
Sbjct: 950 EEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASM 1009
Query: 411 QELEKKLTQVQNSLLKKEKELEK---QQCMATELEMTVKE-AKQDKSKEAECKALQAEVQ 466
++L + +N LL+ EK+ E+ ++ A E +++ +Q ++ +C+ + ++ +
Sbjct: 1010 RDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNE 1069
Query: 467 KLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQR 526
L +E + +L Q + + A+ LE KLQK + K+ A T+ EL+
Sbjct: 1070 DLLARIETLQSNAKLLEVQILEVQRAKAMVDKELE--AEKLQKEQKI-KEHATTVNELEE 1126
Query: 527 ELQMLQKESSMAEKEQTSNRKRVEELSLELSEA----LRKLENSDKEK--RQLQKTVAEQ 580
LQKE +K ++EL L +A L +E +D E+ ++L + + +
Sbjct: 1127 LQVQLQKEKKQLQKT-------MQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNK 1179
Query: 581 DMKMNDMLDRIKHQHREQGSIKCKL----------EEDLQEATKLLEDKREQLKKSKEHE 630
+ K+ D+ IK Q ++Q +++ ++ EE + +LL +++L SK+ E
Sbjct: 1180 NNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAE 1239
Query: 631 K-------LMEGELEALRQEFK-------------------------KKDKTLKENSRK- 657
++GELEA +Q+ + + +TL ++
Sbjct: 1240 TDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRV 1299
Query: 658 --LEEENENLRAELQCCSTQLES-SLNKYNTSQQV------------------------- 689
L+EE +AE +++ ES + +N +Q
Sbjct: 1300 TALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLID 1359
Query: 690 -----IQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDD 744
+QD + + L +LQ++ D L++ LQ T++KEA
Sbjct: 1360 QLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEA-------------- 1405
Query: 745 LTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEI-IAYEERMKKLNTELRKLRGFHQE 803
+ EKL + SE ++ TQT + E + ++ ++++ L E RK Q+
Sbjct: 1406 --ELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQ 1463
Query: 804 --SELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDD 861
S++E F K E + + Q+ +N L+ + L + E + D
Sbjct: 1464 QLSKMEAQLFQLKNEPTTRSPVSSQQSLKN-LRERRNTDLPLLDMHTVTREEGEGMETTD 1522
Query: 862 KEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGE 921
E S T L + + T LE + E+L +L K L+G
Sbjct: 1523 TESVS----SASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGL 1578
Query: 922 KDHLHSVMVHLQQENKKLKKEIEEKKMKAENTR 954
+ L ++ K LK EI + E +
Sbjct: 1579 LRETEATNAILMEQIKLLKSEIRRLERNQEREK 1611
Score = 104 bits (259), Expect = 5e-22
Identities = 166/779 (21%), Positives = 336/779 (43%), Gaps = 95/779 (12%)
Query: 221 SKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNA-----LVLEREK 275
SK+ +I+ ++ + + + ++ + I+ELR+K + ER
Sbjct: 20 SKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLD 79
Query: 276 ALIKLQADFAS-CTATHRYPPSSSEECED-IKKILKHLQEQKDSQCLHVEEYQNLVKDLR 333
AL+ +A+ C + + +E ED + K+ +E + S +V+E +NL +L
Sbjct: 80 ALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELM 139
Query: 334 VELEAVSEQKRNIMKDM---MKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFT 390
SE K N+ K + M +L+L E + ++ LQ +++++ F
Sbjct: 140 AVRSKYSEDKANLQKQLEEAMNTQLEL----SEQLKFQNNSEDNVKKLQEEIEKIRPGFE 195
Query: 391 ETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQ 450
E Q L L+K + D E ++ +TQ+QN + + +K E + +K Q
Sbjct: 196 E-QILYLQK-----QLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQ 249
Query: 451 DKSKEAEC------KALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQ 504
++ KE C K +AE+ KL N L+E ++ A+++ Q K E C LE+ +
Sbjct: 250 EEVKELMCQIEASAKEHEAEINKL-NELKENLVKQCEASEKNIQKKYE-----CELENLR 303
Query: 505 RK--------------LQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVE 550
+ LQ+ +++ + ++ L+ L+ L+ + S+ + E T +
Sbjct: 304 KATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVT----YMN 359
Query: 551 ELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQ 610
L L+L + +++ +R+ + + K+N++L EQG + KL+ +L
Sbjct: 360 NLKLKLEMDAQHIKDEFFHERE------DLEFKINELL----LAKEEQGCVIEKLKSELA 409
Query: 611 EATK-----LLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENL 665
K + + RE ++H+K + E + +K+ TL + L+E+ ENL
Sbjct: 410 GLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENL 469
Query: 666 RAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTT 725
+ E Q ES Q + + +I+ + ES+ QA LQ++ L+T
Sbjct: 470 QQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQK---LRTA 526
Query: 726 IT-KEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQ-------SLTQTQEKKAQLE 777
T K+A + + L E + + + K+LQ+ SL+Q +LE
Sbjct: 527 FTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELE 586
Query: 778 EEIIAYEER----MKKLNTELRKLRGFHQESELE---VHAFDKKLEEMSCQVLQWQKQHQ 830
+I + E + KL ++ FH++ E E + KK+E Q +Q+ + +
Sbjct: 587 GKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVE----QTIQYNSELE 642
Query: 831 NDLKMLAA------KEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGND 884
+ L KE+ + + E ++ +L +DKE S+ ++ +L
Sbjct: 643 QKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKK 702
Query: 885 QIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEI 943
Q+ +LE + Q++ + L + + K + + E+D+L+ ++ + Q + +K ++
Sbjct: 703 QLSRDLEVFLSQKE--DVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQL 759
Score = 83.2 bits (204), Expect = 1e-15
Identities = 160/799 (20%), Positives = 318/799 (39%), Gaps = 148/799 (18%)
Query: 1 MKDEAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQA 60
+KD + + S + L+ I+NL CK + EE +N
Sbjct: 928 LKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEK-----------EEKINKI------ 970
Query: 61 QALAFEESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEK 120
L +++ E SS+ ++ Q +K++L L+ E + + ++ Y+++L +
Sbjct: 971 -KLVAVKAKKELDSSR----KETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLE 1025
Query: 121 QTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNL 180
K+ E + E+E N+ E+ E L L + I S L
Sbjct: 1026 YE------------KQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDL-- 1071
Query: 181 YRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQK 240
L+ IE L+ K+L+ ++ + + + M+ + E +K
Sbjct: 1072 --------LARIETLQSNAKLLEVQI----------------LEVQRAKAMVDKELEAEK 1107
Query: 241 RLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEE 300
E QK+ + + EL + L++EK ++ + +E
Sbjct: 1108 LQKE--QKIKEHATTVNELEEL-----QVQLQKEKKQLQ----------------KTMQE 1144
Query: 301 CEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGL 360
E +KK +Q + + +Y+ L+K+L +L K N ++D ++ E+ +
Sbjct: 1145 LELVKKD----AQQTTLMNMEIADYERLMKELNQKL----TNKNNKIED-LEQEIKIQKQ 1195
Query: 361 REETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQV 420
++ET ++IT LQ +Q+ + + T+ ++L +K K L D E + + Q
Sbjct: 1196 KQET------LQEEITSLQSSVQQYEEKNTKIKQLLVKTKKEL--ADSKQAETDHLILQA 1247
Query: 421 QNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQER 480
LK E E +QQ ++++ +++ K E L+ ++ + +L +Q+
Sbjct: 1248 S---LKGELEASQQQVEVYKIQLAEITSEKHKIHE----HLKTSAEQHQRTLSAYQQRVT 1300
Query: 481 LAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEK 540
++ K E A E + ++ L K K+ M Q E+ A++
Sbjct: 1301 ALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKS-----------MSQAETEGAKQ 1349
Query: 541 EQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGS 600
E+ +++L ++L ++ L+ + E + LQ +E D +L+R +E S
Sbjct: 1350 EREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQ---SEHD----TLLERHNKMLQETVS 1402
Query: 601 IKCKLEEDLQEATKLLEDKREQLKKSKEHEKL---MEGELEALRQEFKKKDKTLKENSRK 657
+ +L E KL + E + EH + + + E LR F+ + + L+E RK
Sbjct: 1403 KEAELRE------KLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRK 1456
Query: 658 LEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQK 717
E L+ +L QL N+ T V ++SL +L+ + + L
Sbjct: 1457 TV---ETLQQQLSKMEAQLFQLKNEPTTRSPV---------SSQQSLKNLRERRNTDLPL 1504
Query: 718 EKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLE 777
+ T E + +S + TQ+LE+L + S L+ L + K +L
Sbjct: 1505 LDMHTVTREEGEGMETTDTESVSSASTYTQSLEQL--LNSPETKLEPPLWHAEFTKEELV 1562
Query: 778 EEIIAYEERMKKLNTELRK 796
+++ + + LN LR+
Sbjct: 1563 QKLSSTTKSADHLNGLLRE 1581
Score = 73.9 bits (180), Expect = 7e-13
Identities = 110/546 (20%), Positives = 229/546 (41%), Gaps = 86/546 (15%)
Query: 475 AKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKE 534
AK+Q L + ++C E LE +L+ + + D I+ L L L E
Sbjct: 34 AKKQMMLIQKAKSRCTE--------LEKEIEELRSKPVTEGT-GDIIKALTERLDALLLE 84
Query: 535 SSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQ 594
+ E++ S +K ++ E+ +++ K+ ++ KE Q ++ + + L ++ +
Sbjct: 85 KAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSK 144
Query: 595 HREQGSIKCKLEEDLQEATKLLEDKREQLK---KSKEHEKLMEGELEALRQEFKKKDKTL 651
+ E K L++ L+EA + EQLK S+++ K ++ E+E +R F+++ L
Sbjct: 145 YSED---KANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYL 201
Query: 652 KENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEI----ALQKESLMSL 707
++ +E + +LQ +E++ Y Q+ I L +E+ A+ +E + L
Sbjct: 202 QKQLDATTDEKKETVTQLQ---NIIEANSQHY---QKNINSLQEELLQLKAIHQEEVKEL 255
Query: 708 QAQLDKALQKEK------HYLQTTITK--EAYDALSRKSAACQ-DDLTQALEKLNH---- 754
Q++ + ++ + + L+ + K EA + +K C+ ++L +A N
Sbjct: 256 MCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQI 315
Query: 755 --------------VTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRG- 799
V + K L+ +L + + + + L++E+ KL + + ++
Sbjct: 316 CSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDE 375
Query: 800 -FHQESELEVHAFDKKL--EEMSCQVLQWQKQHQNDLKMLAAKEEQ--------LREFQE 848
FH+ +LE + L EE C + + + + K EQ + Q+
Sbjct: 376 FFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQK 435
Query: 849 EMAALKENLLEDDKEPCCLPQWSVP--KDTC-RLYRGNDQIMTNLEQWAKQQKVANEKLG 905
E++ L E L D ++ + + K+ C L + + + N E + ++ +LG
Sbjct: 436 EISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELG 495
Query: 906 ------------------NQLREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKK 947
+ + E + + EKD L + LQ EN+KL + +E
Sbjct: 496 ESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQ-QELV 554
Query: 948 MKAENT 953
+ ENT
Sbjct: 555 PELENT 560
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 126 bits (317), Expect = 9e-29
Identities = 209/1018 (20%), Positives = 419/1018 (41%), Gaps = 141/1018 (13%)
Query: 49 EAMNSSHDKKQAQALAFEESEVEFGS----------SKQCHLRQLQQLKKKLLVLQQELE 98
E + S KK E +EV+F S+ L + LK+K V+Q L+
Sbjct: 261 EGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALK 320
Query: 99 FHTE-ELQTSYYSLRQYQSILEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKL 157
++ EL T + L++ +L D CK E++ +E
Sbjct: 321 KSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKER------------ 368
Query: 158 HLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENK 217
+ + D+I +LE+ N++++K S + ++ + + ++ ++ + +
Sbjct: 369 --SNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQEN 426
Query: 218 G--------DHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQ-QDDLIQELRNKLACSNA 268
G +++ S + + Q+ + ++E+ +K + Q + +Q+ + A +
Sbjct: 427 GILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQL 486
Query: 269 LVL--EREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQ 326
V E E+ ++Q+ TA H + K + ++ + Q LH +
Sbjct: 487 KVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQS--------KFVAKENEVQSLHSKLTD 538
Query: 327 NLVKDLRVELEAV----SEQKRNIMKDMMKLEL-DLHGLREETSAHIERKDKDI---TIL 378
LV ++E + SEQKR ++ +++++ D+ E A I++ I T
Sbjct: 539 TLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSA 598
Query: 379 QCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMA 438
+EL E K + + L + + L E++L +QN + E++K Q +A
Sbjct: 599 SVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALA 658
Query: 439 TELEMTVKE---------AKQDKSKEAE--------------------CKALQAEVQKLK 469
E E K DK + E KAL++EVQKL+
Sbjct: 659 NEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQ 718
Query: 470 NSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQ 529
+ E Q + +Q +C +E L+ + L+ GL+ K + + ++ E
Sbjct: 719 TLVSE--QPNKDVVEQMEKCIQEKDEK---LKTVEELLETGLIQVATKEEELNAIRTENS 773
Query: 530 MLQKESS---MAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMND 586
L KE + +Q S VEEL + E K+++ ++ VA ++ + D
Sbjct: 774 SLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQD 833
Query: 587 MLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKK 646
+ IK E G+++ + + L +K+ ++ + LK +E M+ LE ++
Sbjct: 834 LKQEIKALKEEIGNVQLEKAQQLSITSKV-QELQNLLKGKEEQMNTMKAVLEEKEKDLAN 892
Query: 647 KDKTLKENSRKLEEENENLRAELQCCST---QLESSLNKYNTSQQVIQDLNKEIAL---- 699
K L++ L+EENE+L+A +Q + + SS +++ + V+++ E+
Sbjct: 893 TGKWLQD----LQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAM 948
Query: 700 --QKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDD-----LTQALEKL 752
++ES +S + QL + +Q E ++ I + + S+ + +++ +++
Sbjct: 949 LKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEI 1008
Query: 753 NHVTSETKSLQQSLTQTQEKKAQLEEEIIAYE----ERMKKLNTELRKLRGFHQESELEV 808
+ + +E SL+ ++ ++K + ++++ A E E +KKL ++ L
Sbjct: 1009 SGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWL-- 1066
Query: 809 HAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLP 868
H F+KK +E ++K+L E +L+E E L+ LE +K L
Sbjct: 1067 HGFEKKAKECMAGT-----SGSEEVKVL---EHKLKEADEMHTLLQ---LECEKYKSVLA 1115
Query: 869 ---------QWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLS 919
Q SV ++ + D+ ++Q + ++L +LR + K I L
Sbjct: 1116 ETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQEL-ERLRSENKDIENLR 1174
Query: 920 GEKDHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRTESTQREKVCGTL 977
E++HL + + E E+ E K + T L RTE +R+KV G L
Sbjct: 1175 REREHLEMELEKAEMERSTYVTEVRELKAQLNET------LTKLRTEQNERQKVAGDL 1226
Score = 82.0 bits (201), Expect = 3e-15
Identities = 137/694 (19%), Positives = 287/694 (41%), Gaps = 81/694 (11%)
Query: 5 AGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALA 64
A ERDR L SK L+ DI+N++ + K + + LQ L E+A + +K Q++
Sbjct: 624 ASERDR----LTSKEEELK-DIQNMNFLLKAEVQKLQ--ALANEQAAAAHELEKMQQSVY 676
Query: 65 FEESEVEFGSSKQCHLRQLQQLKKKLLVLQQE-LEFHTEELQTSYYS------LRQYQSI 117
++ ++ + H + + K+L Q + L+ ++LQT + Q +
Sbjct: 677 VKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKC 736
Query: 118 LEKQTSDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGD-------- 169
++++ L + + +V EEE+ Q+ A D
Sbjct: 737 IQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLV 796
Query: 170 ------------KIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENK 217
KI S+E L K + ++ L+ ++K L+ E+G + ++ +
Sbjct: 797 EELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQL 856
Query: 218 GDHSKVRIYTSPCMIQEHQ-ETQKRLSEVWQK-VSQQDDLIQELRNKLACSNALVLEREK 275
SKV+ + +E Q T K + E +K ++ +Q+L+ + A V E +
Sbjct: 857 SITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQ 916
Query: 276 ALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVE 335
+K + + E + ++ +LK + S+ +++ Q+ K + +
Sbjct: 917 HNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQ 976
Query: 336 LEAVSEQK----------RNIMKDMMKLELDLHGLREETSA---HIERKDKDITILQCRL 382
+E + +Q ++K + + E ++ GL E + +E + K Q ++
Sbjct: 977 IEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQV 1036
Query: 383 QELQLEFTETQKLTLKKDKFLQEKD--EMLQELEKKLTQVQNSLLKKE--KELEKQQCMA 438
+ ++LE E K K E L EKK + E K LE + A
Sbjct: 1037 EAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEA 1096
Query: 439 TELEMTVK-EAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAG 497
E+ ++ E ++ KS AE + + +QKL+ S+E+ + + ++ ++ + ++ +
Sbjct: 1097 DEMHTLLQLECEKYKSVLAETEGI---LQKLQRSVEQEENKWKVKVDESHKTIKQMQSSF 1153
Query: 498 CHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELS 557
E +L + + I+ L+RE + L+ E AE E+++ V EL +L+
Sbjct: 1154 TSSEQELERL-------RSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLN 1206
Query: 558 EALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRI-----------------KHQHREQGS 600
E L KL E++++ + + + + +I + + E+ +
Sbjct: 1207 ETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKET 1266
Query: 601 IKCKLEEDLQEATKLLEDKREQLKKSKEHEKLME 634
+ L + + + +LL+ +QL K KEH +++E
Sbjct: 1267 MSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
Score = 51.2 bits (121), Expect = 5e-06
Identities = 78/484 (16%), Positives = 198/484 (40%), Gaps = 65/484 (13%)
Query: 4 EAGERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQAL 63
+ +++ V L ++ +L+ +I N+ + K Q+ ++ ++ + ++
Sbjct: 823 KVANKEKTVQDLKQEIKALKEEIGNVQ-LEKAQQLSITSKVQELQNLLKGKEEQMNTMKA 881
Query: 64 AFEESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTS 123
EE E + ++ + L+ LQ+ + L QE+ H + +S + + +L+++ +
Sbjct: 882 VLEEKEKDLANTGKW-LQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKEN 940
Query: 124 DLVLLHHHCKLKE--------------DEVILYEEEMG-----NHNENTGEKLH------ 158
+L L K +E DE L++ ++ N+ + + H
Sbjct: 941 ELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKV 1000
Query: 159 LAQEQLALAG--DKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGEL---------- 206
+++ + ++G +++ SL+ ++ R K +E +E + K + +L
Sbjct: 1001 ISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNL 1060
Query: 207 ---GGIMGQEPENK----GDHSKVRIYTSPCMIQEHQETQKRLSEVWQK----VSQQDDL 255
+ G E + K G + ++E E L +K +++ + +
Sbjct: 1061 SYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGI 1120
Query: 256 IQELRNKLACSN----ALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHL 311
+Q+L+ + V E K + ++Q+ F S S +++ E++++ +HL
Sbjct: 1121 LQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHL 1180
Query: 312 QEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERK 371
+ + + + Y V++L+ +L + R + K+ DLH +
Sbjct: 1181 EMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLH-----------KA 1229
Query: 372 DKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKEL 431
+ + ++Q ++ + + T + + + EK+ M L + +TQ+Q L ++L
Sbjct: 1230 QQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQL 1289
Query: 432 EKQQ 435
K++
Sbjct: 1290 TKEK 1293
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.125 0.336
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,238,660
Number of Sequences: 37866
Number of extensions: 1677601
Number of successful extensions: 36137
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 694
Number of HSP's successfully gapped in prelim test: 1484
Number of HSP's that attempted gapping in prelim test: 9230
Number of HSP's gapped (non-prelim): 10198
length of query: 1007
length of database: 18,247,518
effective HSP length: 112
effective length of query: 895
effective length of database: 14,006,526
effective search space: 12535840770
effective search space used: 12535840770
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.