Guide to the Human Genome
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Search of human proteins with 23510338

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|23510338 ubiquitin-activating enzyme E1 [Homo sapiens]
         (1058 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|23510338 ubiquitin-activating enzyme E1 [Homo sapiens]            2133   0.0  
gi|23510340 ubiquitin-activating enzyme E1 [Homo sapiens]            2133   0.0  
gi|38045948 ubiquitin-like modifier activating enzyme 7 [Homo sa...   862   0.0  
gi|150417996 ubiquitin-activating enzyme E1-like 2 [Homo sapiens]     757   0.0  
gi|4885649 SUMO-1 activating enzyme subunit 2 [Homo sapiens]          158   2e-38
gi|7705473 SUMO1 activating enzyme subunit 1 isoform a [Homo sap...   123   1e-27
gi|4885585 SUMO1 activating enzyme subunit 1 isoform a [Homo sap...   121   4e-27
gi|38045944 ubiquitin-activating enzyme 3 isoform 2 [Homo sapiens]    117   6e-26
gi|38045942 ubiquitin-activating enzyme 3 isoform 1 [Homo sapiens]    117   6e-26
gi|225543288 SUMO1 activating enzyme subunit 1 isoform c [Homo s...   108   2e-23
gi|225543285 SUMO1 activating enzyme subunit 1 isoform b [Homo s...   108   2e-23
gi|4502169 NEDD8 activating enzyme E1 subunit 1 isoform a [Homo ...    79   2e-14
gi|66363686 NEDD8 activating enzyme E1 subunit 1 isoform b [Homo...    71   5e-12
gi|7657339 molybdenum cofactor synthesis 3 [Homo sapiens]              69   2e-11
gi|38327032 ubiquitin-activating enzyme 5 isoform 2 [Homo sapiens]     52   3e-06
gi|13376212 ubiquitin-activating enzyme 5 isoform 1 [Homo sapiens]     52   3e-06
gi|66363688 NEDD8 activating enzyme E1 subunit 1 isoform c [Homo...    39   0.026
gi|7705375 zinc finger and BTB domain containing 7A [Homo sapiens]     34   0.83 
gi|34577105 RNA-binding region containing protein 1 isoform b [H...    32   2.4  
gi|34577107 RNA-binding region containing protein 1 isoform a [H...    32   2.4  

>gi|23510338 ubiquitin-activating enzyme E1 [Homo sapiens]
          Length = 1058

 Score = 2133 bits (5526), Expect = 0.0
 Identities = 1058/1058 (100%), Positives = 1058/1058 (100%)

Query: 1    MSSSPLSKKRRVSGPDPKPGSNCSPAQSVLSEVPSVPTNGMAKNGSEADIDEGLYSRQLY 60
            MSSSPLSKKRRVSGPDPKPGSNCSPAQSVLSEVPSVPTNGMAKNGSEADIDEGLYSRQLY
Sbjct: 1    MSSSPLSKKRRVSGPDPKPGSNCSPAQSVLSEVPSVPTNGMAKNGSEADIDEGLYSRQLY 60

Query: 61   VLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLRE 120
            VLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLRE
Sbjct: 61   VLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLRE 120

Query: 121  EDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVEDFLSGFQVVVLTNTPLEDQLRVGEFCH 180
            EDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVEDFLSGFQVVVLTNTPLEDQLRVGEFCH
Sbjct: 121  EDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVEDFLSGFQVVVLTNTPLEDQLRVGEFCH 180

Query: 181  NRGIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARH 240
            NRGIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARH
Sbjct: 181  NRGIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARH 240

Query: 241  GFESGDFVSFSEVQGMVELNGNQPMEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKK 300
            GFESGDFVSFSEVQGMVELNGNQPMEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKK
Sbjct: 241  GFESGDFVSFSEVQGMVELNGNQPMEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKK 300

Query: 301  ISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALHQFCAQHGRPPRPRNEEDAAELVA 360
            ISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALHQFCAQHGRPPRPRNEEDAAELVA
Sbjct: 301  ISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALHQFCAQHGRPPRPRNEEDAAELVA 360

Query: 361  LAQAVNARALPAVQQNNLDEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPI 420
            LAQAVNARALPAVQQNNLDEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPI
Sbjct: 361  LAQAVNARALPAVQQNNLDEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPI 420

Query: 421  MQWLYFDALECLPEDKEVLTEDKCLQRQNRYDGQVAVFGSDLQEKLGKQKYFLVGAGAIG 480
            MQWLYFDALECLPEDKEVLTEDKCLQRQNRYDGQVAVFGSDLQEKLGKQKYFLVGAGAIG
Sbjct: 421  MQWLYFDALECLPEDKEVLTEDKCLQRQNRYDGQVAVFGSDLQEKLGKQKYFLVGAGAIG 480

Query: 481  CELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMN 540
            CELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMN
Sbjct: 481  CELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMN 540

Query: 541  PHIRVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGT 600
            PHIRVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGT
Sbjct: 541  PHIRVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGT 600

Query: 601  LGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPA 660
            LGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPA
Sbjct: 601  LGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPA 660

Query: 661  ENVNQYLTDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWADCVTWACHHWHTQYSN 720
            ENVNQYLTDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWADCVTWACHHWHTQYSN
Sbjct: 661  ENVNQYLTDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWADCVTWACHHWHTQYSN 720

Query: 721  NIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNPLHLDYVMAAANLFAQTYGLTG 780
            NIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNPLHLDYVMAAANLFAQTYGLTG
Sbjct: 721  NIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNPLHLDYVMAAANLFAQTYGLTG 780

Query: 781  SQDRAAVATFLQSVQVPEFTPKSGVKIHVSDQELQSANASVDDSRLEELKATLPSPDKLP 840
            SQDRAAVATFLQSVQVPEFTPKSGVKIHVSDQELQSANASVDDSRLEELKATLPSPDKLP
Sbjct: 781  SQDRAAVATFLQSVQVPEFTPKSGVKIHVSDQELQSANASVDDSRLEELKATLPSPDKLP 840

Query: 841  GFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYDIPSADRHKSKLIAGKIIPAIATTTAA 900
            GFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYDIPSADRHKSKLIAGKIIPAIATTTAA
Sbjct: 841  GFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYDIPSADRHKSKLIAGKIIPAIATTTAA 900

Query: 901  VVGLVCLELYKVVQGHRQLDSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEV 960
            VVGLVCLELYKVVQGHRQLDSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEV
Sbjct: 901  VVGLVCLELYKVVQGHRQLDSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEV 960

Query: 961  QGLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVS 1020
            QGLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVS
Sbjct: 961  QGLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVS 1020

Query: 1021 RVSKRKLGRHVRALVLELCCNDESGEDVEVPYVRYTIR 1058
            RVSKRKLGRHVRALVLELCCNDESGEDVEVPYVRYTIR
Sbjct: 1021 RVSKRKLGRHVRALVLELCCNDESGEDVEVPYVRYTIR 1058


>gi|23510340 ubiquitin-activating enzyme E1 [Homo sapiens]
          Length = 1058

 Score = 2133 bits (5526), Expect = 0.0
 Identities = 1058/1058 (100%), Positives = 1058/1058 (100%)

Query: 1    MSSSPLSKKRRVSGPDPKPGSNCSPAQSVLSEVPSVPTNGMAKNGSEADIDEGLYSRQLY 60
            MSSSPLSKKRRVSGPDPKPGSNCSPAQSVLSEVPSVPTNGMAKNGSEADIDEGLYSRQLY
Sbjct: 1    MSSSPLSKKRRVSGPDPKPGSNCSPAQSVLSEVPSVPTNGMAKNGSEADIDEGLYSRQLY 60

Query: 61   VLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLRE 120
            VLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLRE
Sbjct: 61   VLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLRE 120

Query: 121  EDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVEDFLSGFQVVVLTNTPLEDQLRVGEFCH 180
            EDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVEDFLSGFQVVVLTNTPLEDQLRVGEFCH
Sbjct: 121  EDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVEDFLSGFQVVVLTNTPLEDQLRVGEFCH 180

Query: 181  NRGIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARH 240
            NRGIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARH
Sbjct: 181  NRGIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARH 240

Query: 241  GFESGDFVSFSEVQGMVELNGNQPMEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKK 300
            GFESGDFVSFSEVQGMVELNGNQPMEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKK
Sbjct: 241  GFESGDFVSFSEVQGMVELNGNQPMEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKK 300

Query: 301  ISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALHQFCAQHGRPPRPRNEEDAAELVA 360
            ISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALHQFCAQHGRPPRPRNEEDAAELVA
Sbjct: 301  ISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALHQFCAQHGRPPRPRNEEDAAELVA 360

Query: 361  LAQAVNARALPAVQQNNLDEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPI 420
            LAQAVNARALPAVQQNNLDEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPI
Sbjct: 361  LAQAVNARALPAVQQNNLDEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPI 420

Query: 421  MQWLYFDALECLPEDKEVLTEDKCLQRQNRYDGQVAVFGSDLQEKLGKQKYFLVGAGAIG 480
            MQWLYFDALECLPEDKEVLTEDKCLQRQNRYDGQVAVFGSDLQEKLGKQKYFLVGAGAIG
Sbjct: 421  MQWLYFDALECLPEDKEVLTEDKCLQRQNRYDGQVAVFGSDLQEKLGKQKYFLVGAGAIG 480

Query: 481  CELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMN 540
            CELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMN
Sbjct: 481  CELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMN 540

Query: 541  PHIRVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGT 600
            PHIRVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGT
Sbjct: 541  PHIRVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGT 600

Query: 601  LGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPA 660
            LGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPA
Sbjct: 601  LGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPA 660

Query: 661  ENVNQYLTDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWADCVTWACHHWHTQYSN 720
            ENVNQYLTDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWADCVTWACHHWHTQYSN
Sbjct: 661  ENVNQYLTDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWADCVTWACHHWHTQYSN 720

Query: 721  NIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNPLHLDYVMAAANLFAQTYGLTG 780
            NIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNPLHLDYVMAAANLFAQTYGLTG
Sbjct: 721  NIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNPLHLDYVMAAANLFAQTYGLTG 780

Query: 781  SQDRAAVATFLQSVQVPEFTPKSGVKIHVSDQELQSANASVDDSRLEELKATLPSPDKLP 840
            SQDRAAVATFLQSVQVPEFTPKSGVKIHVSDQELQSANASVDDSRLEELKATLPSPDKLP
Sbjct: 781  SQDRAAVATFLQSVQVPEFTPKSGVKIHVSDQELQSANASVDDSRLEELKATLPSPDKLP 840

Query: 841  GFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYDIPSADRHKSKLIAGKIIPAIATTTAA 900
            GFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYDIPSADRHKSKLIAGKIIPAIATTTAA
Sbjct: 841  GFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYDIPSADRHKSKLIAGKIIPAIATTTAA 900

Query: 901  VVGLVCLELYKVVQGHRQLDSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEV 960
            VVGLVCLELYKVVQGHRQLDSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEV
Sbjct: 901  VVGLVCLELYKVVQGHRQLDSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEV 960

Query: 961  QGLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVS 1020
            QGLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVS
Sbjct: 961  QGLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVS 1020

Query: 1021 RVSKRKLGRHVRALVLELCCNDESGEDVEVPYVRYTIR 1058
            RVSKRKLGRHVRALVLELCCNDESGEDVEVPYVRYTIR
Sbjct: 1021 RVSKRKLGRHVRALVLELCCNDESGEDVEVPYVRYTIR 1058


>gi|38045948 ubiquitin-like modifier activating enzyme 7 [Homo
            sapiens]
          Length = 1012

 Score =  862 bits (2228), Expect = 0.0
 Identities = 474/1018 (46%), Positives = 644/1018 (63%), Gaps = 25/1018 (2%)

Query: 50   IDEGLYSRQLYVLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQW 109
            +DE LYSRQLYVLG  AM+R+Q + VLVSGL+GLG E+AKN++L GV ++TLHD     W
Sbjct: 10   LDEELYSRQLYVLGSPAMQRIQGARVLVSGLQGLGAEVAKNLVLMGVGSLTLHDPHPTCW 69

Query: 110  ADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVEDFLSGFQVVVLTNTPL 169
            +DL++QF L E+D+ ++RAE SQ  LA+LN  V V  +TG + ED L  FQVVVLT   L
Sbjct: 70   SDLAAQFLLSEQDLERSRAEASQELLAQLNRAVQVVVHTGDITEDLLLDFQVVVLTAAKL 129

Query: 170  EDQLRVGEFCHNRGIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMVSMVTKDNP 229
            E+QL+VG  CH  G+  + ADTRGL GQLFCDFGE+  + D    +PL+A +  +++ +P
Sbjct: 130  EEQLKVGTLCHKHGVCFLAADTRGLVGQLFCDFGEDFTVQDPTEAEPLTAAIQHISQGSP 189

Query: 230  GVVTCLDEAR-HGFESGDFVSFSEVQGMVELNGNQPMEIKVLGPYTFSICDTSNFSDYIR 288
            G++T    A  H F  GD V+FS ++GMVELN   P  I V    +  I DT+ FS Y+R
Sbjct: 190  GILTLRKGANTHYFRDGDLVTFSGIEGMVELNDCDPRSIHVREDGSLEIGDTTTFSRYLR 249

Query: 289  GGIVSQVKVPKKISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALHQFCAQHGRPPR 348
            GG +++VK PK +  KSL  +L +P  V     +      LH  F ALH+F   HGRPP+
Sbjct: 250  GGAITEVKRPKTVRHKSLDTALLQPHVVAQSSQEVHHAHCLHQAFCALHKFQHLHGRPPQ 309

Query: 349  PRNEEDAAELVALAQAVN--ARALPAVQQNNLDEDLIRKLAYVAAGDLAPINAFIGGLAA 406
            P +  DA  +V LA+ +    R      +  LDE L+R +A  +AG L+P+ A +G +AA
Sbjct: 310  PWDPVDAETVVGLARDLEPLKRTEEEPLEEPLDEALVRTVALSSAGVLSPMVAMLGAVAA 369

Query: 407  QEVMKACSGKFMPIMQWLYFDALECLPEDKEVL-TEDKCLQRQNRYDGQVAVFGSDLQEK 465
            QEV+KA S KFMP+ QWLYFDAL+CLPED E+L + + C  R +RYDGQ+AVFG+  QEK
Sbjct: 370  QEVLKAISRKFMPLDQWLYFDALDCLPEDGELLPSPEDCALRGSRYDGQIAVFGAGFQEK 429

Query: 466  LGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFRPWDVT 525
            L +Q Y LVGAGAIGCELLK FA++GLG G  G + V DMD IE+SNL+RQFLFR  DV 
Sbjct: 430  LRRQHYLLVGAGAIGCELLKVFALVGLGAGNSGGLTVVDMDHIERSNLSRQFLFRSQDVG 489

Query: 526  KLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDARMYMD 585
            + K++ AAAA R +NP ++V      + P TE IY D+FF  +DGVA ALD+  AR Y+ 
Sbjct: 490  RPKAEVAAAAARGLNPDLQVIPLTYPLDPTTEHIYGDNFFSRVDGVAAALDSFQARRYVA 549

Query: 586  RRCVYYRKPLLESGTLGTKGNVQVVIPFLTESY------SSSQDPPEKSIPICTLKNFPN 639
             RC +Y KPLLE+GT GT G+  V +P +TE+Y      ++S+D P    P+CT++ FP+
Sbjct: 550  ARCTHYLKPLLEAGTSGTWGSATVFMPHVTEAYRAPASAAASEDAP---YPVCTVRYFPS 606

Query: 640  AIEHTLQWARDEFEGLFKQPAENVNQYLTDPKFVERTLRLAGTQPLEVLEAVQRSLVLQR 699
              EHTLQWAR EFE LF+  AE +N +    +       +   Q L +L+ V   ++  R
Sbjct: 607  TAEHTLQWARHEFEELFRLSAETINHH---QQAHTSLADMDEPQTLTLLKPV-LGVLRVR 662

Query: 700  PQTWADCVTWACHHWHTQYSNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNP 759
            PQ W DCV WA  HW   +   I+QLL +FPP+++   G PFWSGPK+CP PL FD N  
Sbjct: 663  PQNWQDCVAWALGHWKLCFHYGIKQLLRHFPPNKVLEDGTPFWSGPKQCPQPLEFDTNQD 722

Query: 760  LHLDYVMAAANLFAQTYGLTGSQDRAAVATFLQSVQVPEFTPKSGVKIHVSDQELQSANA 819
             HL YV+AAANL+AQ +GL GSQD  A+   L+ +  P+  P+    I  S+ EL SA+A
Sbjct: 723  THLLYVLAAANLYAQMHGLPGSQDWTALRELLKLLPQPD--PQQMAPIFASNLELASASA 780

Query: 820  SVDDSRLEELKATLPSPDKLPGFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYDIPSAD 879
                 + +EL   L      P  K  P+ FEKDDDSNFH+DF+VAA++LR +NY IP  +
Sbjct: 781  EFGPEQQKELNKALEVWSVGPPLK--PLMFEKDDDSNFHVDFVVAAASLRCQNYGIPPVN 838

Query: 880  RHKSKLIAGKIIPAIATTTAAVVGLVCLELYKVVQGHRQLDSYKNGFLNLALPFFGFSEP 939
            R +SK I G+IIPAIATTTAAV GL+ LELYKVV G R   ++++ +L+LA  +     P
Sbjct: 839  RAQSKRIVGQIIPAIATTTAAVAGLLGLELYKVVSGPRPRSAFRHSYLHLAENYLIRYMP 898

Query: 940  LAAPRHQYYNQEWTLWDRFEVQGLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYS 999
             A     +++ +WT WDR +V   QP   E TL+  L + + +H L + +L  G ++LY+
Sbjct: 899  FAPAIQTFHHLKWTSWDRLKVPAGQP---ERTLESLLAHLQEQHGLRVRILLHGSALLYA 955

Query: 1000 FFMPAAKLKERLDQPMTEIVSRVSKRKLGRHVRALVLELCCNDESGEDVEVPYVRYTI 1057
                  K  + L   +TE+V +++ +      R LVLEL C  +  ED   P + Y +
Sbjct: 956  AGWSPEKQAQHLPLRVTELVQQLTGQAPAPGQRVLVLELSCEGDD-EDTAFPPLHYEL 1012


>gi|150417996 ubiquitin-activating enzyme E1-like 2 [Homo sapiens]
          Length = 1052

 Score =  757 bits (1955), Expect = 0.0
 Identities = 436/1033 (42%), Positives = 626/1033 (60%), Gaps = 45/1033 (4%)

Query: 46   SEADIDEGLYSRQLYVLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQG 105
            +  +ID+ LYSRQ YVLG  AM+++  S V +SG+ GLG+EIAKN++L G+KAVT+HD  
Sbjct: 35   ASVEIDDALYSRQRYVLGDTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTE 94

Query: 106  TAQWADLSSQFYLREEDI--GKNRAEVSQPRLAELNSYVPVTAYTGPLVE----DFLSGF 159
              Q  DL + F+L E+D+   +NRAE     +AELN YV VT+ + P  E     FL  +
Sbjct: 95   KCQAWDLGTNFFLSEDDVVNKRNRAEAVLKHIAELNPYVHVTSSSVPFNETTDLSFLDKY 154

Query: 160  QVVVLTNTPLEDQLRVGEFCHNR--GIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPL 217
            Q VVLT   L  Q ++ +FC ++   IK + AD  G++ +LFCDFG+E  + D+ GE+P 
Sbjct: 155  QCVVLTEMKLPLQKKINDFCRSQCPPIKFISADVHGIWSRLFCDFGDEFEVLDTTGEEPK 214

Query: 218  SAMVSMVTKDNPGVVTCLDEARHGFESGDFVSFSEVQGMVELNGNQPMEIKVLGPYTFSI 277
               +S +T+ NPG+VTCL+   H  E+G F++F E+ GM  LNG+   +I V+ P++FSI
Sbjct: 215  EIFISNITQANPGIVTCLENHPHKLETGQFLTFREINGMTGLNGSI-QQITVISPFSFSI 273

Query: 278  CDTSNFSDYIRGGIVSQVKVPKKISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALH 337
             DT+    Y+ GGI  QVK PK + F+SL   L  P  ++ DF+    P ++H    AL 
Sbjct: 274  GDTTELEPYLHGGIAVQVKTPKTVFFESLERQLKHPKCLIVDFSNPEAPLEIHTAMLALD 333

Query: 338  QFCAQHGRPPRPRNEEDAAELVALAQAVNARALPAVQQNNLDEDLIRKLAYVAAGDLAPI 397
            QF  ++ R P    ++D+ EL+ LA +++       ++ +++ D++  L++ A G L+P+
Sbjct: 334  QFQEKYSRKPNVGCQQDSEELLKLATSISETL---EEKPDVNADIVHWLSWTAQGFLSPL 390

Query: 398  NAFIGGLAAQEVMKACSGKFMPIMQWLYFDALECLPEDKEVLTEDKC---LQRQNRYDGQ 454
             A +GG+A+QEV+KA +GKF P+ QWLY +A + +    E L + +C   L R +RYD  
Sbjct: 391  AAAVGGVASQEVLKAVTGKFSPLCQWLYLEAADIV----ESLGKPECEEFLPRGDRYDAL 446

Query: 455  VAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCG-EGGEIIVTDMDTIEKSNL 513
             A  G  L +KL     FLVG GAIGCE+LKNFA++G+G   E G I VTD D IEKSNL
Sbjct: 447  RACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNL 506

Query: 514  NRQFLFRPWDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERIYDDDFFQNLDGVAN 573
            NRQFLFRP  + K KS TAA A  ++N  I++ +H N+V P TE IY+D+F+   D +  
Sbjct: 507  NRQFLFRPHHIQKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTKQDVIIT 566

Query: 574  ALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKSIPICT 633
            ALDNV+AR Y+D RC+   +PLL+SGT+GTKG+ +V++P LTESY+S +DPPE+ IP CT
Sbjct: 567  ALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHTEVIVPHLTESYNSHRDPPEEEIPFCT 626

Query: 634  LKNFPNAIEHTLQWARDEFEGLFKQPAENVNQYLTDPKFVERTL-RLAGTQPLEVLEAVQ 692
            LK+FP AIEHT+QWARD+FE  F       N++       E  L ++     LE    V 
Sbjct: 627  LKSFPAAIEHTIQWARDKFESSFSHKPSLFNKFWQTYSSAEEVLQKIQSGHSLEGCFQVI 686

Query: 693  RSLVLQRPQTWADCVTWACHHWHTQYSNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPL 752
            + L+ +RP+ W+ CV  A   +   +++   QLLH FP D     G+ FW  PKR P P+
Sbjct: 687  K-LLSRRPRNWSQCVELARLKFEKYFNHKALQLLHCFPLDIRLKDGSLFWQSPKRPPSPI 745

Query: 753  TFDVNNPLHLDYVMAAANLFAQTYGLTGSQD---RAAVATFLQSVQVPEFTPKSGVKIHV 809
             FD+N PLHL ++  AA L+A  Y +  +++     A+   L  V++ EF P +  K+  
Sbjct: 746  KFDLNEPLHLSFLQNAAKLYATVYCIPFAEEDLSADALLNILSEVKIQEFKPSN--KVVQ 803

Query: 810  SDQELQSAN---ASVDDSR---LEELKATLPSPDKLPGFKMYPIDFEKDDDSNFHMDFIV 863
            +D+  +  +    S +D R    +  KA L +       +M  + FEKDDD N H+DFI 
Sbjct: 804  TDETARKPDHVPISSEDERNAIFQLEKAILSNEATKSDLQMAVLSFEKDDDHNGHIDFIT 863

Query: 864  AASNLRAENYDIPSADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYKVVQGHRQLDSYK 923
            AASNLRA+ Y I  ADR K+K IAGKIIPAIATTTA V GLV LE+ KV  G+   ++YK
Sbjct: 864  AASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTATVSGLVALEMIKVTGGY-PFEAYK 922

Query: 924  NGFLNLALPFFGFSEPLAAPRHQYYNQ-EWTLWDRFEVQGLQPNGEEMTLKQFLDYFKTE 982
            N FLNLA+P   F+E     + +  N   +T+WDR+ V G     E+ TL  F++  K +
Sbjct: 923  NCFLNLAIPIVVFTETTEVRKTKIRNGISFTIWDRWTVHG----KEDFTLLDFINAVKEK 978

Query: 983  HKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVSRVSKRKLGRHVRALVLELCCND 1042
            + +E TM+ QGV MLY   MP     +RL   M ++V   +++K       L +    + 
Sbjct: 979  YGIEPTMVVQGVKMLYVPVMPGH--AKRLKLTMHKLVKPTTEKK----YVDLTVSFAPDI 1032

Query: 1043 ESGEDVEVPYVRY 1055
            +  ED+  P VRY
Sbjct: 1033 DGDEDLPGPPVRY 1045


>gi|4885649 SUMO-1 activating enzyme subunit 2 [Homo sapiens]
          Length = 640

 Score =  158 bits (400), Expect = 2e-38
 Identities = 149/477 (31%), Positives = 227/477 (47%), Gaps = 76/477 (15%)

Query: 461 DLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFR 520
           +L E +   +  +VGAG IGCELLKN  + G        I + D+DTI+ SNLNRQFLF+
Sbjct: 10  ELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFS-----HIDLIDLDTIDVSNLNRQFLFQ 64

Query: 521 PWDVTKLKSDTAAAAVRQMNPHIRVTS-HQNRVGPDTERIYDDDFFQNLDGVANALDNVD 579
              V + K+  A  +V Q  P   + + H + + PD    Y+ +FF+    V NALDN  
Sbjct: 65  KKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPD----YNVEFFRQFILVMNALDNRA 120

Query: 580 ARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPN 639
           AR +++R C+    PL+ESGT G  G V  +   +TE Y     P +++ P CT++N P+
Sbjct: 121 ARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPS 180

Query: 640 AIEHTLQWARDEFEGLFKQPAENVNQYLTDPKFVERTLRLAGTQPLEV---LEAVQRSLV 696
              H + WA+  F  LF +  E+ +Q ++     +R    A  +P E      A      
Sbjct: 181 EPIHCIVWAKYLFNQLFGE--EDADQEVSP----DRADPEAAWEPTEAEARARASNEDGD 234

Query: 697 LQRPQT--WADCVTWACHHWHTQ-YSNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLT 753
           ++R  T  WA    +      T+ + ++IR LL     D+L       W   KR P    
Sbjct: 235 IKRISTKEWAKSTGYDPVKLFTKLFKDDIRYLL---TMDKL-------WR--KRKP---- 278

Query: 754 FDVNNPLHLDYVMAAANLFAQTYGLTGSQDRAAVATFLQSVQVPEFTPKSGVKIHVSDQE 813
                P+ LD+                SQ     A+  Q+       P+ G+K    DQ+
Sbjct: 279 -----PVPLDWAEVQ------------SQGEETNASDQQN------EPQLGLK----DQQ 311

Query: 814 LQSAN--ASVDDSRLEELKATLPSPDKLPGFKMYPIDFEKDDDSNFHMDFIVAASNLRAE 871
           +      A +    +E L+  L   +K  G ++    ++KDD S   MDF+ +A+NLR  
Sbjct: 312 VLDVKSYARLFSKSIETLRVHL--AEKGDGAELI---WDKDDPS--AMDFVTSAANLRMH 364

Query: 872 NYDIPSADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYKVVQGHRQLDSYKNGFLN 928
            + +    R   K +AG IIPAIATT A + GL+ LE  K++ G  ++D  +  FLN
Sbjct: 365 IFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSG--KIDQCRTIFLN 419



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 35/142 (24%), Positives = 71/142 (50%), Gaps = 5/142 (3%)

Query: 62  LGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLREE 121
           L  E  + +    VLV G  G+G E+ KN++L G   + L D  T   ++L+ QF  +++
Sbjct: 7   LPRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKK 66

Query: 122 DIGKNRAEVSQPRLAELNSYVPVTAYTGPLVE-DF-LSGFQVVVLTNTPLEDQL---RVG 176
            +G+++A+V++  + +      + AY   ++  D+ +  F+  +L    L+++     V 
Sbjct: 67  HVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVN 126

Query: 177 EFCHNRGIKLVVADTRGLFGQL 198
             C    + L+ + T G  GQ+
Sbjct: 127 RMCLAADVPLIESGTAGYLGQV 148


>gi|7705473 SUMO1 activating enzyme subunit 1 isoform a [Homo
           sapiens]
          Length = 346

 Score =  123 bits (308), Expect = 1e-27
 Identities = 104/389 (26%), Positives = 162/389 (41%), Gaps = 65/389 (16%)

Query: 45  GSEADIDEGLYSRQLYVLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQ 104
           G  ++ +   Y RQ+ + G EA KRL+ S VL+ GL+GLG EIAKN+IL GVK +T+ D 
Sbjct: 9   GGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDH 68

Query: 105 GTAQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGPL---VEDFLSGFQV 161
                 D  +QF +R   +G+NRAE S  R   LN  V V   T  +    E F + F  
Sbjct: 69  EQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDA 128

Query: 162 VVLTNTPLEDQLRVGEFCHNRGIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMV 221
           V LT    +  ++V + CH   IK    D  G  G  F + GE   + +           
Sbjct: 129 VCLTCCSRDVIVKVDQICHKNSIKFFTGDAFGYHGYTFANLGEHEFVEEE---------- 178

Query: 222 SMVTKDNPGVVTCLDEARHGFESGDFVSFSEVQGMVELNGNQPMEIKVLGPYTFSICDTS 281
                      T + +  HG E G     +++                         D+S
Sbjct: 179 -----------TDVAKVSHGVEDGPDTKRAKL-------------------------DSS 202

Query: 282 NFSDYIRGGIVSQVKVPKKISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALHQFCA 341
             +   +  +   VK   ++ + S  A            A   R    +   Q L +F  
Sbjct: 203 ETTMVKKKVVFCPVKEALEVDWSSEKAK-----------AALKRTTSDYFLLQVLLKFRT 251

Query: 342 QHGRPPRPRNEEDAAELVALAQAVNARALPAVQQNNLDEDLIRKLAYVAAGDLAPINAFI 401
             GR P     E+ +EL+   +     +L  +  + L ED +R        ++AP+ A +
Sbjct: 252 DKGRDPSSDTYEEDSELLLQIRNDVLDSL-GISPDLLPEDFVR----YCFSEMAPVCAVV 306

Query: 402 GGLAAQEVMKACSGKFMPIMQWLYFDALE 430
           GG+ AQE++KA S +  P   + +FD ++
Sbjct: 307 GGILAQEIVKALSQRDPPHNNFFFFDGMK 335



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 34/141 (24%), Positives = 64/141 (45%), Gaps = 14/141 (9%)

Query: 450 RYDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTDMDTIE 509
           +YD Q+ ++G + Q++L   +  LVG   +G E+ KN  + G+       + + D + + 
Sbjct: 18  QYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV-----KGLTMLDHEQVT 72

Query: 510 KSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERI--YDDDFFQN 567
             +   QFL R   V + +++ +    + +NP + V         DTE I    + FF  
Sbjct: 73  PEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVK-------VDTEDIEKKPESFFTQ 125

Query: 568 LDGVANALDNVDARMYMDRRC 588
            D V     + D  + +D+ C
Sbjct: 126 FDAVCLTCCSRDVIVKVDQIC 146


>gi|4885585 SUMO1 activating enzyme subunit 1 isoform a [Homo
           sapiens]
          Length = 346

 Score =  121 bits (303), Expect = 4e-27
 Identities = 105/389 (26%), Positives = 158/389 (40%), Gaps = 65/389 (16%)

Query: 45  GSEADIDEGLYSRQLYVLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQ 104
           G  ++ +   Y RQ+ + G EA KRL+ S VL+ GL+GLG EIAKN+IL GVK +T+ D 
Sbjct: 9   GGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDH 68

Query: 105 GTAQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGPLV---EDFLSGFQV 161
                 D  +QF +R   +G+NRAE S  R   LN  V V   T  +    E F + F  
Sbjct: 69  EQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDA 128

Query: 162 VVLTNTPLEDQLRVGEFCHNRGIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMV 221
           V LT    +  ++V + CH   IK    D  G  G  F + GE   + +           
Sbjct: 129 VCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEK---------- 178

Query: 222 SMVTKDNPGVVTCLDEARHGFESGDFVSFSEVQGMVELNGNQPMEIKVLGPYTFSICDTS 281
           + V K + GV    D  R   +S +                                   
Sbjct: 179 TKVAKVSQGVEDGPDTKRAKLDSSE----------------------------------- 203

Query: 282 NFSDYIRGGIVSQVKVPKKISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALHQFCA 341
                          V KK+ F  +  +L          A   R    +   Q L +F  
Sbjct: 204 ------------TTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRT 251

Query: 342 QHGRPPRPRNEEDAAELVALAQAVNARALPAVQQNNLDEDLIRKLAYVAAGDLAPINAFI 401
             GR P     E+ +EL+   +     +L  +  + L ED +R        ++AP+ A +
Sbjct: 252 DKGRDPSSDTYEEDSELLLQIRNDVLDSL-GISPDLLPEDFVR----YCFSEMAPVCAVV 306

Query: 402 GGLAAQEVMKACSGKFMPIMQWLYFDALE 430
           GG+ AQE++KA S +  P   + +FD ++
Sbjct: 307 GGILAQEIVKALSQRDPPHNNFFFFDGMK 335



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 34/141 (24%), Positives = 64/141 (45%), Gaps = 14/141 (9%)

Query: 450 RYDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTDMDTIE 509
           +YD Q+ ++G + Q++L   +  LVG   +G E+ KN  + G+       + + D + + 
Sbjct: 18  QYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV-----KGLTMLDHEQVT 72

Query: 510 KSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERI--YDDDFFQN 567
             +   QFL R   V + +++ +    + +NP + V         DTE I    + FF  
Sbjct: 73  PEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVK-------VDTEDIEKKPESFFTQ 125

Query: 568 LDGVANALDNVDARMYMDRRC 588
            D V     + D  + +D+ C
Sbjct: 126 FDAVCLTCCSRDVIVKVDQIC 146


>gi|38045944 ubiquitin-activating enzyme 3 isoform 2 [Homo sapiens]
          Length = 449

 Score =  117 bits (293), Expect = 6e-26
 Identities = 68/202 (33%), Positives = 110/202 (54%), Gaps = 24/202 (11%)

Query: 462 LQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFRP 521
           LQ  L   K  ++GAG +GCELLKN A+ G       +I V DMDTI+ SNLNRQFLFRP
Sbjct: 49  LQFLLDTCKVLVIGAGGLGCELLKNLALSGFR-----QIHVIDMDTIDVSNLNRQFLFRP 103

Query: 522 WDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDAR 581
            D+ + K++ AA  +    P+  V  H N++     + ++D F++    +   LD++ AR
Sbjct: 104 KDIGRPKAEVAAEFLNDRVPNCNVVPHFNKI-----QDFNDTFYRQFHIIVCGLDSIIAR 158

Query: 582 MYMDRRCVYYRK------------PLLESGTLGTKGNVQVVIPFLTESYSSSQD--PPEK 627
            +++   +                PL++ GT G KGN +V++P +T     + +  PP+ 
Sbjct: 159 RWINGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQV 218

Query: 628 SIPICTLKNFPNAIEHTLQWAR 649
           + P+CT+ + P   EH +++ R
Sbjct: 219 NFPMCTIASMPRLPEHCIEYVR 240



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 32/75 (42%), Positives = 44/75 (58%), Gaps = 5/75 (6%)

Query: 70  LQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLREEDIGKNRAE 129
           L T  VLV G  GLG E+ KN+ L G + + + D  T   ++L+ QF  R +DIG+ +AE
Sbjct: 53  LDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAE 112

Query: 130 VSQPRLAE-LNSYVP 143
           V+    AE LN  VP
Sbjct: 113 VA----AEFLNDRVP 123



 Score = 37.4 bits (85), Expect = 0.075
 Identities = 18/61 (29%), Positives = 32/61 (52%)

Query: 852 DDDSNFHMDFIVAASNLRAENYDIPSADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYK 911
           D D   H+ +I   S  RA  Y+I       ++ +  +IIPA+A+T A +  +   E++K
Sbjct: 257 DGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFK 316

Query: 912 V 912
           +
Sbjct: 317 I 317


>gi|38045942 ubiquitin-activating enzyme 3 isoform 1 [Homo sapiens]
          Length = 463

 Score =  117 bits (293), Expect = 6e-26
 Identities = 68/202 (33%), Positives = 110/202 (54%), Gaps = 24/202 (11%)

Query: 462 LQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFRP 521
           LQ  L   K  ++GAG +GCELLKN A+ G       +I V DMDTI+ SNLNRQFLFRP
Sbjct: 63  LQFLLDTCKVLVIGAGGLGCELLKNLALSGFR-----QIHVIDMDTIDVSNLNRQFLFRP 117

Query: 522 WDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDAR 581
            D+ + K++ AA  +    P+  V  H N++     + ++D F++    +   LD++ AR
Sbjct: 118 KDIGRPKAEVAAEFLNDRVPNCNVVPHFNKI-----QDFNDTFYRQFHIIVCGLDSIIAR 172

Query: 582 MYMDRRCVYYRK------------PLLESGTLGTKGNVQVVIPFLTESYSSSQD--PPEK 627
            +++   +                PL++ GT G KGN +V++P +T     + +  PP+ 
Sbjct: 173 RWINGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQV 232

Query: 628 SIPICTLKNFPNAIEHTLQWAR 649
           + P+CT+ + P   EH +++ R
Sbjct: 233 NFPMCTIASMPRLPEHCIEYVR 254



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 32/75 (42%), Positives = 44/75 (58%), Gaps = 5/75 (6%)

Query: 70  LQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLREEDIGKNRAE 129
           L T  VLV G  GLG E+ KN+ L G + + + D  T   ++L+ QF  R +DIG+ +AE
Sbjct: 67  LDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAE 126

Query: 130 VSQPRLAE-LNSYVP 143
           V+    AE LN  VP
Sbjct: 127 VA----AEFLNDRVP 137



 Score = 37.4 bits (85), Expect = 0.075
 Identities = 18/61 (29%), Positives = 32/61 (52%)

Query: 852 DDDSNFHMDFIVAASNLRAENYDIPSADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYK 911
           D D   H+ +I   S  RA  Y+I       ++ +  +IIPA+A+T A +  +   E++K
Sbjct: 271 DGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFK 330

Query: 912 V 912
           +
Sbjct: 331 I 331


>gi|225543288 SUMO1 activating enzyme subunit 1 isoform c [Homo
           sapiens]
          Length = 266

 Score =  108 bits (271), Expect = 2e-23
 Identities = 69/188 (36%), Positives = 94/188 (50%), Gaps = 7/188 (3%)

Query: 45  GSEADIDEGLYSRQLYVLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQ 104
           G  ++ +   Y RQ+ + G EA KRL+ S VL+ GL+GLG EIAKN+IL GVK +T+ D 
Sbjct: 9   GGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDH 68

Query: 105 GTAQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGPL---VEDFLSGFQV 161
                 D  +QF +R   +G+NRAE S  R   LN  V V   T  +    E F + F  
Sbjct: 69  EQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDA 128

Query: 162 VVLTNTPLEDQLRVGEFCHNRGIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMV 221
           V LT    +  ++V + CH   IK    D  G  G  F + GE   +     E+   A V
Sbjct: 129 VCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVE----EKTKVAKV 184

Query: 222 SMVTKDNP 229
           S   +D P
Sbjct: 185 SQGVEDGP 192



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 34/141 (24%), Positives = 64/141 (45%), Gaps = 14/141 (9%)

Query: 450 RYDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTDMDTIE 509
           +YD Q+ ++G + Q++L   +  LVG   +G E+ KN  + G+       + + D + + 
Sbjct: 18  QYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV-----KGLTMLDHEQVT 72

Query: 510 KSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERI--YDDDFFQN 567
             +   QFL R   V + +++ +    + +NP + V         DTE I    + FF  
Sbjct: 73  PEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVK-------VDTEDIEKKPESFFTQ 125

Query: 568 LDGVANALDNVDARMYMDRRC 588
            D V     + D  + +D+ C
Sbjct: 126 FDAVCLTCCSRDVIVKVDQIC 146


>gi|225543285 SUMO1 activating enzyme subunit 1 isoform b [Homo
           sapiens]
          Length = 299

 Score =  108 bits (271), Expect = 2e-23
 Identities = 69/188 (36%), Positives = 94/188 (50%), Gaps = 7/188 (3%)

Query: 45  GSEADIDEGLYSRQLYVLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQ 104
           G  ++ +   Y RQ+ + G EA KRL+ S VL+ GL+GLG EIAKN+IL GVK +T+ D 
Sbjct: 9   GGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDH 68

Query: 105 GTAQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGPL---VEDFLSGFQV 161
                 D  +QF +R   +G+NRAE S  R   LN  V V   T  +    E F + F  
Sbjct: 69  EQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDA 128

Query: 162 VVLTNTPLEDQLRVGEFCHNRGIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMV 221
           V LT    +  ++V + CH   IK    D  G  G  F + GE   +     E+   A V
Sbjct: 129 VCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVE----EKTKVAKV 184

Query: 222 SMVTKDNP 229
           S   +D P
Sbjct: 185 SQGVEDGP 192



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 34/141 (24%), Positives = 64/141 (45%), Gaps = 14/141 (9%)

Query: 450 RYDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTDMDTIE 509
           +YD Q+ ++G + Q++L   +  LVG   +G E+ KN  + G+       + + D + + 
Sbjct: 18  QYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV-----KGLTMLDHEQVT 72

Query: 510 KSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERI--YDDDFFQN 567
             +   QFL R   V + +++ +    + +NP + V         DTE I    + FF  
Sbjct: 73  PEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVK-------VDTEDIEKKPESFFTQ 125

Query: 568 LDGVANALDNVDARMYMDRRC 588
            D V     + D  + +D+ C
Sbjct: 126 FDAVCLTCCSRDVIVKVDQIC 146


>gi|4502169 NEDD8 activating enzyme E1 subunit 1 isoform a [Homo
           sapiens]
          Length = 534

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 52/160 (32%), Positives = 75/160 (46%), Gaps = 16/160 (10%)

Query: 50  IDEGLYSRQLYVLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQW 109
           + E  Y RQL + G    + L+++ V +      G EI KN++L G+ + T+ D      
Sbjct: 8   LKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSG 67

Query: 110 ADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVED-----------FLSG 158
            D  + F+L+   IGKNRAE +   L ELNS V     +G  VE+           F   
Sbjct: 68  EDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDV-----SGSFVEESPENLLDNDPSFFCR 122

Query: 159 FQVVVLTNTPLEDQLRVGEFCHNRGIKLVVADTRGLFGQL 198
           F VVV T  P    LR+ +   N  I L++  T GL G +
Sbjct: 123 FTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYM 162



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 46/212 (21%), Positives = 87/212 (41%), Gaps = 16/212 (7%)

Query: 445 LQRQNRYDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTD 504
           L ++ +YD Q+ ++G   QE L      L+ A A G E+LKN  + G+     G   + D
Sbjct: 7   LLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGI-----GSFTIID 61

Query: 505 MDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERIYDDD- 563
            + +   +    F  +   + K +++ A   ++++N  +      + V    E + D+D 
Sbjct: 62  GNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDV----SGSFVEESPENLLDNDP 117

Query: 564 -FFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQ 622
            FF     V          + +       + PLL   T G  G ++++I    + +   +
Sbjct: 118 SFFCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIII----KEHPVIE 173

Query: 623 DPPEKSIPICTL-KNFPNAIEHTLQWARDEFE 653
             P+ ++    L K FP   EH   +  D  E
Sbjct: 174 SHPDNALEDLRLDKPFPELREHFQSYDLDHME 205



 Score = 38.9 bits (89), Expect = 0.026
 Identities = 42/220 (19%), Positives = 87/220 (39%), Gaps = 22/220 (10%)

Query: 204 EEMILTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARHGFESGDFVSFSEVQGMVELNGNQ 263
           +E +  +  G  P+   +  +  D+   +   +  R   +       + V  +++  G  
Sbjct: 312 KEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNHVAKLLQSIGQA 371

Query: 264 P-----MEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKKISFKSLVASLAEPDFVVT 318
           P      E+K+L       C  S F   +R   +++      I+   +++S+  PD  + 
Sbjct: 372 PESISEKELKLL-------CSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPDNEIV 424

Query: 319 DFAKFSRPAQLHIGFQALHQFCAQHGRPPRPRNEEDAAELVALAQAVNARALPAVQQNNL 378
                     L++  +A+ +F  Q GR P   N +   ++  L   +            +
Sbjct: 425 ----------LYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMV 474

Query: 379 DEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFM 418
            +D + +     A +   I AF+GG AAQEV+K  + +F+
Sbjct: 475 KDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFV 514


>gi|66363686 NEDD8 activating enzyme E1 subunit 1 isoform b [Homo
           sapiens]
          Length = 528

 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 47/147 (31%), Positives = 68/147 (46%), Gaps = 16/147 (10%)

Query: 63  GHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLREED 122
           G    + L+++ V +      G EI KN++L G+ + T+ D       D  + F+L+   
Sbjct: 15  GDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSS 74

Query: 123 IGKNRAEVSQPRLAELNSYVPVTAYTGPLVED-----------FLSGFQVVVLTNTPLED 171
           IGKNRAE +   L ELNS V     +G  VE+           F   F VVV T  P   
Sbjct: 75  IGKNRAEAAMEFLQELNSDV-----SGSFVEESPENLLDNDPSFFCRFTVVVATQLPEST 129

Query: 172 QLRVGEFCHNRGIKLVVADTRGLFGQL 198
            LR+ +   N  I L++  T GL G +
Sbjct: 130 SLRLADVLWNSQIPLLICRTYGLVGYM 156



 Score = 38.9 bits (89), Expect = 0.026
 Identities = 42/220 (19%), Positives = 87/220 (39%), Gaps = 22/220 (10%)

Query: 204 EEMILTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARHGFESGDFVSFSEVQGMVELNGNQ 263
           +E +  +  G  P+   +  +  D+   +   +  R   +       + V  +++  G  
Sbjct: 306 KEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNHVAKLLQSIGQA 365

Query: 264 P-----MEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKKISFKSLVASLAEPDFVVT 318
           P      E+K+L       C  S F   +R   +++      I+   +++S+  PD  + 
Sbjct: 366 PESISEKELKLL-------CSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPDNEIV 418

Query: 319 DFAKFSRPAQLHIGFQALHQFCAQHGRPPRPRNEEDAAELVALAQAVNARALPAVQQNNL 378
                     L++  +A+ +F  Q GR P   N +   ++  L   +            +
Sbjct: 419 ----------LYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMV 468

Query: 379 DEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFM 418
            +D + +     A +   I AF+GG AAQEV+K  + +F+
Sbjct: 469 KDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFV 508



 Score = 37.7 bits (86), Expect = 0.058
 Identities = 43/212 (20%), Positives = 82/212 (38%), Gaps = 16/212 (7%)

Query: 445 LQRQNRYDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTD 504
           +  Q     +  ++G   QE L      L+ A A G E+LKN  + G+     G   + D
Sbjct: 1   MDAQQTKTNEARLWGDHGQEALESAHVCLINATATGTEILKNLVLPGI-----GSFTIID 55

Query: 505 MDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERIYDDD- 563
            + +   +    F  +   + K +++ A   ++++N  +      + V    E + D+D 
Sbjct: 56  GNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDV----SGSFVEESPENLLDNDP 111

Query: 564 -FFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQ 622
            FF     V          + +       + PLL   T G  G ++++I    + +   +
Sbjct: 112 SFFCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIII----KEHPVIE 167

Query: 623 DPPEKSIPICTL-KNFPNAIEHTLQWARDEFE 653
             P+ ++    L K FP   EH   +  D  E
Sbjct: 168 SHPDNALEDLRLDKPFPELREHFQSYDLDHME 199


>gi|7657339 molybdenum cofactor synthesis 3 [Homo sapiens]
          Length = 460

 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 52/176 (29%), Positives = 83/176 (47%), Gaps = 15/176 (8%)

Query: 436 KEVLTEDKCLQRQNRYDGQVAV--FGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLG 493
           K  L+ D+ L    RY  Q+ +   G   Q +LG     +VG G +GC L +  A  G+G
Sbjct: 52  KAALSRDEIL----RYSRQLVLPELGVHGQLRLGTACVLIVGCGGLGCPLAQYLAAAGVG 107

Query: 494 CGEGGEIIVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVG 553
                 + + D D +E SNL RQ L       + K+ +AAA++R++N  +    +   + 
Sbjct: 108 -----RLGLVDYDVVEMSNLARQVLHGEALAGQAKAFSAAASLRRLNSAVECVPYTQALT 162

Query: 554 PDTERIYDDDFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQV 609
           P T      D  +  D VA+  DNV  R  ++  CV   +PL+ +  L  +G + V
Sbjct: 163 PATAL----DLVRRYDVVADCSDNVPTRYLVNDACVLAGRPLVSASALRFEGQITV 214



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 45/150 (30%), Positives = 66/150 (44%), Gaps = 6/150 (4%)

Query: 55  YSRQLYV--LGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADL 112
           YSRQL +  LG     RL T+ VL+ G  GLG  +A+ +   GV  + L D    + ++L
Sbjct: 63  YSRQLVLPELGVHGQLRLGTACVLIVGCGGLGCPLAQYLAAAGVGRLGLVDYDVVEMSNL 122

Query: 113 SSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVE----DFLSGFQVVVLTNTP 168
           + Q    E   G+ +A  +   L  LNS V    YT  L      D +  + VV   +  
Sbjct: 123 ARQVLHGEALAGQAKAFSAAASLRRLNSAVECVPYTQALTPATALDLVRRYDVVADCSDN 182

Query: 169 LEDQLRVGEFCHNRGIKLVVADTRGLFGQL 198
           +  +  V + C   G  LV A      GQ+
Sbjct: 183 VPTRYLVNDACVLAGRPLVSASALRFEGQI 212


>gi|38327032 ubiquitin-activating enzyme 5 isoform 2 [Homo sapiens]
          Length = 348

 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 40/159 (25%), Positives = 70/159 (44%), Gaps = 16/159 (10%)

Query: 464 EKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFRPWD 523
           EK+      +VG G +G    +     G+G     ++++ D D +E +N+NR F F+P  
Sbjct: 13  EKIRTFAVAIVGVGGVGSVTAEMLTRCGIG-----KLLLFDYDKVELANMNRLF-FQPHQ 66

Query: 524 VTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERIYDDDFFQN--------LDGVANAL 575
               K   A   +R +NP +    H   +       +  D   N        +D V + +
Sbjct: 67  AGLSKVQAAEHTLRNINPDVLFEVHNYNITTVENFQHFMDRISNGGLEEGKPVDLVLSCV 126

Query: 576 DNVDARMYMDRRCVYYRKPLLESGTL--GTKGNVQVVIP 612
           DN +ARM ++  C    +  +ESG       G++Q++IP
Sbjct: 127 DNFEARMTINTACNELGQTWMESGVSENAVSGHIQLIIP 165


>gi|13376212 ubiquitin-activating enzyme 5 isoform 1 [Homo sapiens]
          Length = 404

 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 40/159 (25%), Positives = 70/159 (44%), Gaps = 16/159 (10%)

Query: 464 EKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFRPWD 523
           EK+      +VG G +G    +     G+G     ++++ D D +E +N+NR F F+P  
Sbjct: 69  EKIRTFAVAIVGVGGVGSVTAEMLTRCGIG-----KLLLFDYDKVELANMNRLF-FQPHQ 122

Query: 524 VTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERIYDDDFFQN--------LDGVANAL 575
               K   A   +R +NP +    H   +       +  D   N        +D V + +
Sbjct: 123 AGLSKVQAAEHTLRNINPDVLFEVHNYNITTVENFQHFMDRISNGGLEEGKPVDLVLSCV 182

Query: 576 DNVDARMYMDRRCVYYRKPLLESGTL--GTKGNVQVVIP 612
           DN +ARM ++  C    +  +ESG       G++Q++IP
Sbjct: 183 DNFEARMTINTACNELGQTWMESGVSENAVSGHIQLIIP 221


>gi|66363688 NEDD8 activating enzyme E1 subunit 1 isoform c [Homo
           sapiens]
          Length = 445

 Score = 38.9 bits (89), Expect = 0.026
 Identities = 42/220 (19%), Positives = 87/220 (39%), Gaps = 22/220 (10%)

Query: 204 EEMILTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARHGFESGDFVSFSEVQGMVELNGNQ 263
           +E +  +  G  P+   +  +  D+   +   +  R   +       + V  +++  G  
Sbjct: 223 KEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNHVAKLLQSIGQA 282

Query: 264 P-----MEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKKISFKSLVASLAEPDFVVT 318
           P      E+K+L       C  S F   +R   +++      I+   +++S+  PD  + 
Sbjct: 283 PESISEKELKLL-------CSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPDNEIV 335

Query: 319 DFAKFSRPAQLHIGFQALHQFCAQHGRPPRPRNEEDAAELVALAQAVNARALPAVQQNNL 378
                     L++  +A+ +F  Q GR P   N +   ++  L   +            +
Sbjct: 336 ----------LYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMV 385

Query: 379 DEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFM 418
            +D + +     A +   I AF+GG AAQEV+K  + +F+
Sbjct: 386 KDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFV 425


>gi|7705375 zinc finger and BTB domain containing 7A [Homo sapiens]
          Length = 584

 Score = 33.9 bits (76), Expect = 0.83
 Identities = 18/51 (35%), Positives = 24/51 (47%), Gaps = 2/51 (3%)

Query: 8   KKRRVSG--PDPKPGSNCSPAQSVLSEVPSVPTNGMAKNGSEADIDEGLYS 56
           +K RV G  PDP PG+  +P        P    NG  K+  + D DE + S
Sbjct: 499 RKPRVRGGAPDPSPGATATPGAPAQPSSPDARRNGQEKHFKDEDEDEDVAS 549


>gi|34577105 RNA-binding region containing protein 1 isoform b [Homo
            sapiens]
          Length = 121

 Score = 32.3 bits (72), Expect = 2.4
 Identities = 22/70 (31%), Positives = 35/70 (50%), Gaps = 1/70 (1%)

Query: 932  PFFGFSEPLAAPRHQYYNQEWTLWDRFEVQGLQPNGEEMTLKQFLDYF-KTEHKLEITML 990
            P  GF  PLAAP   + +Q+ T + +  V GL  +  + +L+++ + F   E  + IT  
Sbjct: 10   PSAGFPRPLAAPGAMHGSQKDTTFTKIFVGGLPYHTTDASLRKYFEGFGDIEEAVVITDR 69

Query: 991  SQGVSMLYSF 1000
              G S  Y F
Sbjct: 70   QTGKSRGYGF 79


>gi|34577107 RNA-binding region containing protein 1 isoform a [Homo
            sapiens]
          Length = 239

 Score = 32.3 bits (72), Expect = 2.4
 Identities = 22/70 (31%), Positives = 35/70 (50%), Gaps = 1/70 (1%)

Query: 932  PFFGFSEPLAAPRHQYYNQEWTLWDRFEVQGLQPNGEEMTLKQFLDYF-KTEHKLEITML 990
            P  GF  PLAAP   + +Q+ T + +  V GL  +  + +L+++ + F   E  + IT  
Sbjct: 10   PSAGFPRPLAAPGAMHGSQKDTTFTKIFVGGLPYHTTDASLRKYFEGFGDIEEAVVITDR 69

Query: 991  SQGVSMLYSF 1000
              G S  Y F
Sbjct: 70   QTGKSRGYGF 79


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,626,394
Number of Sequences: 37866
Number of extensions: 1843062
Number of successful extensions: 4558
Number of sequences better than 10.0: 20
Number of HSP's better than 10.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 4471
Number of HSP's gapped (non-prelim): 42
length of query: 1058
length of database: 18,247,518
effective HSP length: 113
effective length of query: 945
effective length of database: 13,968,660
effective search space: 13200383700
effective search space used: 13200383700
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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