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Search of human proteins with 23503283
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23503283 TBC1 domain family, member 21 [Homo sapiens]
(336 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23503283 TBC1 domain family, member 21 [Homo sapiens] 687 0.0
gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens] 136 2e-32
gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens] 136 2e-32
gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens] 136 2e-32
gi|13375952 TBC1 domain family, member 17 [Homo sapiens] 120 2e-27
gi|33563376 TBC1 domain family, member 16 [Homo sapiens] 82 5e-16
gi|54607014 TBC1 domain family, member 25 [Homo sapiens] 56 5e-08
gi|34147456 TBC domain-containing protein kinase-like [Homo sapi... 52 6e-07
gi|21389447 TBC1 domain family, member 20 [Homo sapiens] 41 0.002
gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo sa... 40 0.004
gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo sa... 40 0.004
gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sap... 40 0.004
gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sap... 40 0.004
gi|40068063 TBC1 domain family, member 22B [Homo sapiens] 38 0.011
gi|22507409 TBC1 domain family, member 22A [Homo sapiens] 37 0.033
gi|190014603 TBC1 domain family, member 13 [Homo sapiens] 35 0.12
gi|223633919 hypothetical protein LOC285550 [Homo sapiens] 31 1.4
gi|11863130 phosphatidylinositol N-acetylglucosaminyltransferase... 30 2.3
gi|110224463 phosphatidylinositol N-acetylglucosaminyltransferas... 30 2.3
gi|197304777 TBC1 domain family, member 5 isoform a [Homo sapiens] 30 3.0
gi|197304775 TBC1 domain family, member 5 isoform b [Homo sapiens] 30 3.0
gi|7661998 TBC1 domain family, member 5 isoform b [Homo sapiens] 30 3.0
gi|63047871 hypothetical protein LOC122525 [Homo sapiens] 30 4.0
gi|222352143 TBC1 domain family, member 2 [Homo sapiens] 29 5.2
gi|28558969 mediator complex subunit 23 isoform b [Homo sapiens] 29 5.2
gi|28558971 mediator complex subunit 23 isoform a [Homo sapiens] 29 5.2
gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens] 29 5.2
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens] 29 5.2
gi|38348348 TBC1 domain family, member 10C [Homo sapiens] 29 5.2
gi|5032281 dystrophin Dp427c isoform [Homo sapiens] 29 6.8
>gi|23503283 TBC1 domain family, member 21 [Homo sapiens]
Length = 336
Score = 687 bits (1774), Expect = 0.0
Identities = 336/336 (100%), Positives = 336/336 (100%)
Query: 1 MTTLSPENSLSARQSASFILVKRKPPIDKTEWDSFFDESGHLAKSRDFICVNILERGLHP 60
MTTLSPENSLSARQSASFILVKRKPPIDKTEWDSFFDESGHLAKSRDFICVNILERGLHP
Sbjct: 1 MTTLSPENSLSARQSASFILVKRKPPIDKTEWDSFFDESGHLAKSRDFICVNILERGLHP 60
Query: 61 FVRTEAWKFLTGYFSWQSSQDERLTVDSMRRKNYKALCQMYEKIQPLLENLHRNFTETRN 120
FVRTEAWKFLTGYFSWQSSQDERLTVDSMRRKNYKALCQMYEKIQPLLENLHRNFTETRN
Sbjct: 61 FVRTEAWKFLTGYFSWQSSQDERLTVDSMRRKNYKALCQMYEKIQPLLENLHRNFTETRN 120
Query: 121 NIARDIQKIYDKDPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQLMVEHDH 180
NIARDIQKIYDKDPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQLMVEHDH
Sbjct: 121 NIARDIQKIYDKDPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQLMVEHDH 180
Query: 181 ETFWLFQFFLQKTEHSCVINIGVAKNLDMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWF 240
ETFWLFQFFLQKTEHSCVINIGVAKNLDMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWF
Sbjct: 181 ETFWLFQFFLQKTEHSCVINIGVAKNLDMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWF 240
Query: 241 CFCFQRAFKSFDDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQVLQESMGGDDILLAC 300
CFCFQRAFKSFDDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQVLQESMGGDDILLAC
Sbjct: 241 CFCFQRAFKSFDDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQVLQESMGGDDILLAC 300
Query: 301 NNLIDLDADELISAACVVYAELIQKDVPQTLKDFFL 336
NNLIDLDADELISAACVVYAELIQKDVPQTLKDFFL
Sbjct: 301 NNLIDLDADELISAACVVYAELIQKDVPQTLKDFFL 336
>gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens]
Length = 682
Score = 136 bits (343), Expect = 2e-32
Identities = 87/322 (27%), Positives = 164/322 (50%), Gaps = 17/322 (5%)
Query: 20 LVKRKPPIDKTEWDSFFDESGHLAKSRDFICVNILERGLHPFVRTEAWKFLTGYFSWQSS 79
+V+R+ P+ EW D G + D + I GL +R +AWKFL GYF W S+
Sbjct: 301 VVQRREPVSLEEWTKNIDSEGRILNV-DNMKQMIFRGGLSHALRKQAWKFLLGYFPWDST 359
Query: 80 QDERLTVDSMRRKNYKALCQMYEKIQPLLENLHRNFTETRNNIARDIQ------KIYD-K 132
++ER + + Y + ++ I E + + R+ I +D+ K Y+ +
Sbjct: 360 KEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQ 419
Query: 133 DPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQLMVEHDHETFWLFQFFLQK 192
D G +L L IL+ + + Y QG +++ ++E++ + FW F ++ +
Sbjct: 420 DNPGLIL-----LHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQ 474
Query: 193 TEHSCVINI-GVAKNLDMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWFCFCFQRAFKSF 251
+ + G+ L LSTL+ LD F +L+ + +G + F W F+R F SF
Sbjct: 475 MHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREF-SF 533
Query: 252 DDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQVLQESMGGDDILLACNNL-IDLDADE 310
D+ RLWEV+ T PC NF +L+ ++L+ ++Q++++ G ++IL N L + +D ++
Sbjct: 534 LDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVED 593
Query: 311 LISAACVVYAELIQ-KDVPQTL 331
++ A + ++++ K++PQ +
Sbjct: 594 ILCKAEAISLQMVKCKELPQAV 615
>gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens]
Length = 696
Score = 136 bits (343), Expect = 2e-32
Identities = 87/322 (27%), Positives = 164/322 (50%), Gaps = 17/322 (5%)
Query: 20 LVKRKPPIDKTEWDSFFDESGHLAKSRDFICVNILERGLHPFVRTEAWKFLTGYFSWQSS 79
+V+R+ P+ EW D G + D + I GL +R +AWKFL GYF W S+
Sbjct: 315 VVQRREPVSLEEWTKNIDSEGRILNV-DNMKQMIFRGGLSHALRKQAWKFLLGYFPWDST 373
Query: 80 QDERLTVDSMRRKNYKALCQMYEKIQPLLENLHRNFTETRNNIARDIQ------KIYD-K 132
++ER + + Y + ++ I E + + R+ I +D+ K Y+ +
Sbjct: 374 KEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQ 433
Query: 133 DPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQLMVEHDHETFWLFQFFLQK 192
D G +L L IL+ + + Y QG +++ ++E++ + FW F ++ +
Sbjct: 434 DNPGLIL-----LHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQ 488
Query: 193 TEHSCVINI-GVAKNLDMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWFCFCFQRAFKSF 251
+ + G+ L LSTL+ LD F +L+ + +G + F W F+R F SF
Sbjct: 489 MHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREF-SF 547
Query: 252 DDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQVLQESMGGDDILLACNNL-IDLDADE 310
D+ RLWEV+ T PC NF +L+ ++L+ ++Q++++ G ++IL N L + +D ++
Sbjct: 548 LDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVED 607
Query: 311 LISAACVVYAELIQ-KDVPQTL 331
++ A + ++++ K++PQ +
Sbjct: 608 ILCKAEAISLQMVKCKELPQAV 629
>gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens]
Length = 713
Score = 136 bits (343), Expect = 2e-32
Identities = 87/322 (27%), Positives = 164/322 (50%), Gaps = 17/322 (5%)
Query: 20 LVKRKPPIDKTEWDSFFDESGHLAKSRDFICVNILERGLHPFVRTEAWKFLTGYFSWQSS 79
+V+R+ P+ EW D G + D + I GL +R +AWKFL GYF W S+
Sbjct: 332 VVQRREPVSLEEWTKNIDSEGRILNV-DNMKQMIFRGGLSHALRKQAWKFLLGYFPWDST 390
Query: 80 QDERLTVDSMRRKNYKALCQMYEKIQPLLENLHRNFTETRNNIARDIQ------KIYD-K 132
++ER + + Y + ++ I E + + R+ I +D+ K Y+ +
Sbjct: 391 KEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQ 450
Query: 133 DPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQLMVEHDHETFWLFQFFLQK 192
D G +L L IL+ + + Y QG +++ ++E++ + FW F ++ +
Sbjct: 451 DNPGLIL-----LHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQ 505
Query: 193 TEHSCVINI-GVAKNLDMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWFCFCFQRAFKSF 251
+ + G+ L LSTL+ LD F +L+ + +G + F W F+R F SF
Sbjct: 506 MHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREF-SF 564
Query: 252 DDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQVLQESMGGDDILLACNNL-IDLDADE 310
D+ RLWEV+ T PC NF +L+ ++L+ ++Q++++ G ++IL N L + +D ++
Sbjct: 565 LDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVED 624
Query: 311 LISAACVVYAELIQ-KDVPQTL 331
++ A + ++++ K++PQ +
Sbjct: 625 ILCKAEAISLQMVKCKELPQAV 646
>gi|13375952 TBC1 domain family, member 17 [Homo sapiens]
Length = 648
Score = 120 bits (300), Expect = 2e-27
Identities = 87/312 (27%), Positives = 150/312 (48%), Gaps = 18/312 (5%)
Query: 21 VKRKPPIDKTEWDSFFDESGHLAKSRDFICVNILERGLHPFVRTEAWKFLTGYFSWQSSQ 80
V+R PP+ + EW G L + + + I GL P +R EAWKFL GY SW+ +
Sbjct: 275 VERGPPVTEEEWARHVGPEGRLQQVPE-LKNRIFSGGLSPSLRREAWKFLLGYLSWEGTA 333
Query: 81 DERLTVDSMRRKNYKALCQMYEKIQPLLENLHRNFTETRNNIARDIQ------KIYD--K 132
+E + Y + ++ + P E + R+ I RD+ K Y+ +
Sbjct: 334 EEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPE 393
Query: 133 DPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQLMVEHDHETFWLFQFFLQK 192
+P +L D ILL + + Y QG +++ +++++ + FW F F++
Sbjct: 394 NPGLGLLND------ILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMEL 447
Query: 193 TEHSCVINIGVAKN-LDMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWFCFCFQRAFKSF 251
+ + + K L L L+ LDP+ + L + +G++ F W F+R F F
Sbjct: 448 VQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFP-F 506
Query: 252 DDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQVLQESMGGDDILLACNNL-IDLDADE 310
DV RLWEVL TG P N +LVA ++L M R+ ++ G ++IL N L + L ++
Sbjct: 507 PDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVED 566
Query: 311 LISAACVVYAEL 322
+++ A ++ +L
Sbjct: 567 VLTRAEALHRQL 578
>gi|33563376 TBC1 domain family, member 16 [Homo sapiens]
Length = 767
Score = 82.4 bits (202), Expect = 5e-16
Identities = 74/292 (25%), Positives = 124/292 (42%), Gaps = 26/292 (8%)
Query: 57 GLHPFVRTEAWKFLTGYFSWQSSQDERLTVDSMRRKNYKALCQMYEKIQPLLENLHRNFT 116
G+ +R E W FL Y+S +S+ +ER + +RK Y + Q + P HR F
Sbjct: 425 GIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTP---EEHRAFW 481
Query: 117 ETRNNIARDIQKIYDKDPL----------GNVLIDKKRLEKILLLSYVCNTQAEYQQGFH 166
R++Q DKD + G + + + +ILL V N Y QG
Sbjct: 482 -------RNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMS 534
Query: 167 EMMMLFQLMVEHDHETFWLFQFFLQKTEH-SCVINIGVAKNLDMLSTLITFLDPVFAEHL 225
+++ V + +TFW F +Q T S + + K L L L+ F +HL
Sbjct: 535 DLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHL 594
Query: 226 KGKGAGAVQSLF--PWFCFCFQRAFKSFDDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVR 283
G +Q LF W CF+R F + + R+WE F + + +++ +
Sbjct: 595 VSLGEDGLQMLFCHRWLLLCFKREFPEAEAL-RIWEACWAHYQTDYFHLFICVAIVAIYG 653
Query: 284 EQVLQESMGGDDILLACNNLIDLDADELI--SAACVVYAELIQKDVPQTLKD 333
+ V+++ + D +LL NL EL+ A ++Y + +P +L D
Sbjct: 654 DDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHD 705
>gi|54607014 TBC1 domain family, member 25 [Homo sapiens]
Length = 688
Score = 55.8 bits (133), Expect = 5e-08
Identities = 52/248 (20%), Positives = 105/248 (42%), Gaps = 13/248 (5%)
Query: 24 KPPIDKTEWDSFFDESGHLAKSRDFICVNILERGLHPFVRTEAWKFLTGYFSWQSSQDER 83
KPP+ E+ ++ + G L++ + + + I G+ P +R W++L + + ER
Sbjct: 196 KPPLSDAEFHTYLNHEGQLSRPEE-LRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRER 254
Query: 84 LTVDSMRRKNYKAL-CQMYEKIQPLLENLHRNFTETRNNIARDIQKIYDKDPLGNVLIDK 142
+ + + Y+ L + ++ P + R+ + +D+ + P D
Sbjct: 255 MDYMKRKSREYEQLKSEWAQRANP------EDLEFIRSTVLKDVLRTDRAHPYYAGPEDG 308
Query: 143 KRLEKI--LLLSY-VCNTQAEYQQGFHEMMMLFQLMVEHDHETFWLFQFFLQK-TEHSCV 198
L + LL +Y V + Q Y QG ++ +++H+ F F +++ +
Sbjct: 309 PHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHP 368
Query: 199 INIGVAKNLDMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWFCFCFQRAFKSFDDVWRLW 258
+A L L+ DP F ++L+ GA + + W +R F +FDD R+
Sbjct: 369 DGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREF-AFDDALRML 427
Query: 259 EVLLTGKP 266
EV + P
Sbjct: 428 EVTWSSLP 435
>gi|34147456 TBC domain-containing protein kinase-like [Homo
sapiens]
Length = 830
Score = 52.4 bits (124), Expect = 6e-07
Identities = 47/206 (22%), Positives = 87/206 (42%), Gaps = 23/206 (11%)
Query: 118 TRNNIARDIQKIYDKDPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQLMVE 177
T I DI + + D L + + ++L V + Y QG + F L +
Sbjct: 438 TDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPF-LYLN 496
Query: 178 HDHETF-----------WLFQFFLQKTEHSCVINIGVAKNLDMLSTLITFLDPVFAEHLK 226
++E +L+ FFL+ H + + L + S +I F DP + HL
Sbjct: 497 FNNEALAYACMSAFIPKYLYNFFLKDNSHV------IQEYLTVFSQMIAFHDPELSNHLN 550
Query: 227 GKGAGAVQSLFPWFCFCFQRAFKSFDDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQV 286
G PWF F F ++ LW+ LL G +F + ++LQ +R+++
Sbjct: 551 EIGFIPDLYAIPWFLTMFTHVF-PLHKIFHLWDTLLLGN--SSFPFCIGVAILQQLRDRL 607
Query: 287 LQESMGGDDILLACNNLIDLDADELI 312
L + G ++ +L ++L ++D + +
Sbjct: 608 L--ANGFNECILLFSDLPEIDIERCV 631
>gi|21389447 TBC1 domain family, member 20 [Homo sapiens]
Length = 403
Score = 40.8 bits (94), Expect = 0.002
Identities = 52/243 (21%), Positives = 102/243 (41%), Gaps = 18/243 (7%)
Query: 84 LTVDSMRRKNYKALCQMYEKIQPLLENLH-RNFTETRNNIARDIQKIYDKDPLGNVLIDK 142
L D +RRK + L + P + + R ++ + D+++ + P G +
Sbjct: 60 LLTDEIRRKVWPKLLNVNANDPPPISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR 119
Query: 143 KRLEK----ILLLSYVCNTQAEYQQGFHEMMMLFQLMVEHDHETFWLFQFFLQKTEHSCV 198
+ L++ I+LL N Q Y QG+H++++ F L+V T + +
Sbjct: 120 EGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDFMD 179
Query: 199 INIGVAKN-LDMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWFCFCFQRAFKSFDDVWRL 257
+ K+ L+ L +I ++P + ++ G + +L W F F V RL
Sbjct: 180 PTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFAL-SWLITWFGHVLSDFRHVVRL 238
Query: 258 WEVLLTGKPCRNFQVLVAYSMLQMVREQVLQESMGGDDILLACNNLI-----DLDADELI 312
++ L C + +++ + RE QE + D + + ++L+ DL + LI
Sbjct: 239 YDFFLA---CHPLMPIYFAAVIVLYRE---QEVLDCDCDMASVHHLLSQIPQDLPYETLI 292
Query: 313 SAA 315
S A
Sbjct: 293 SRA 295
>gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo
sapiens]
Length = 1032
Score = 39.7 bits (91), Expect = 0.004
Identities = 35/194 (18%), Positives = 87/194 (44%), Gaps = 5/194 (2%)
Query: 115 FTETRNNIARDIQKIYDKDPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQL 174
+T + I +D+Q+ D++ + ++L I+ + + Y QG +++ +
Sbjct: 816 YTVNLHRIEKDVQRC-DRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLV 874
Query: 175 MVEHDHETFWLFQFFLQKTEHSCVINIGVAKNLDMLSTLITFLDPVFAEHLKGKGAGA-V 233
+++ + F F +++ + + + + +LI LD E + G
Sbjct: 875 ILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHF 934
Query: 234 QSLFPWFCFCFQRAFKSFDDVWRLWEVLLTGK--PCRNFQVLVAYSMLQMVREQVLQESM 291
+ WF F+R +DDV+ +WE + K ++ + +A +++++ R+ +L+ +M
Sbjct: 935 YFCYRWFLLDFKRELV-YDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNM 993
Query: 292 GGDDILLACNNLID 305
DI+ N + +
Sbjct: 994 DFTDIIKFFNEMAE 1007
>gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo
sapiens]
Length = 1093
Score = 39.7 bits (91), Expect = 0.004
Identities = 35/194 (18%), Positives = 87/194 (44%), Gaps = 5/194 (2%)
Query: 115 FTETRNNIARDIQKIYDKDPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQL 174
+T + I +D+Q+ D++ + ++L I+ + + Y QG +++ +
Sbjct: 877 YTVNLHRIEKDVQRC-DRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLV 935
Query: 175 MVEHDHETFWLFQFFLQKTEHSCVINIGVAKNLDMLSTLITFLDPVFAEHLKGKGAGA-V 233
+++ + F F +++ + + + + +LI LD E + G
Sbjct: 936 ILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHF 995
Query: 234 QSLFPWFCFCFQRAFKSFDDVWRLWEVLLTGK--PCRNFQVLVAYSMLQMVREQVLQESM 291
+ WF F+R +DDV+ +WE + K ++ + +A +++++ R+ +L+ +M
Sbjct: 996 YFCYRWFLLDFKRELV-YDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNM 1054
Query: 292 GGDDILLACNNLID 305
DI+ N + +
Sbjct: 1055 DFTDIIKFFNEMAE 1068
Score = 29.6 bits (65), Expect = 4.0
Identities = 11/31 (35%), Positives = 18/31 (58%)
Query: 57 GLHPFVRTEAWKFLTGYFSWQSSQDERLTVD 87
G+ P +R W FL G++ + ++ ER VD
Sbjct: 562 GIQPEIRKAVWPFLLGHYQFGMTETERKEVD 592
>gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sapiens]
Length = 1087
Score = 39.7 bits (91), Expect = 0.004
Identities = 35/194 (18%), Positives = 87/194 (44%), Gaps = 5/194 (2%)
Query: 115 FTETRNNIARDIQKIYDKDPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQL 174
+T + I +D+Q+ D++ + ++L I+ + + Y QG +++ +
Sbjct: 871 YTVNLHRIEKDVQRC-DRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLV 929
Query: 175 MVEHDHETFWLFQFFLQKTEHSCVINIGVAKNLDMLSTLITFLDPVFAEHLKGKGAGA-V 233
+++ + F F +++ + + + + +LI LD E + G
Sbjct: 930 ILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHF 989
Query: 234 QSLFPWFCFCFQRAFKSFDDVWRLWEVLLTGK--PCRNFQVLVAYSMLQMVREQVLQESM 291
+ WF F+R +DDV+ +WE + K ++ + +A +++++ R+ +L+ +M
Sbjct: 990 YFCYRWFLLDFKRELV-YDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNM 1048
Query: 292 GGDDILLACNNLID 305
DI+ N + +
Sbjct: 1049 DFTDIIKFFNEMAE 1062
>gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sapiens]
Length = 1148
Score = 39.7 bits (91), Expect = 0.004
Identities = 35/194 (18%), Positives = 87/194 (44%), Gaps = 5/194 (2%)
Query: 115 FTETRNNIARDIQKIYDKDPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQL 174
+T + I +D+Q+ D++ + ++L I+ + + Y QG +++ +
Sbjct: 932 YTVNLHRIEKDVQRC-DRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLV 990
Query: 175 MVEHDHETFWLFQFFLQKTEHSCVINIGVAKNLDMLSTLITFLDPVFAEHLKGKGAGA-V 233
+++ + F F +++ + + + + +LI LD E + G
Sbjct: 991 ILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHF 1050
Query: 234 QSLFPWFCFCFQRAFKSFDDVWRLWEVLLTGK--PCRNFQVLVAYSMLQMVREQVLQESM 291
+ WF F+R +DDV+ +WE + K ++ + +A +++++ R+ +L+ +M
Sbjct: 1051 YFCYRWFLLDFKRELV-YDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNM 1109
Query: 292 GGDDILLACNNLID 305
DI+ N + +
Sbjct: 1110 DFTDIIKFFNEMAE 1123
Score = 29.6 bits (65), Expect = 4.0
Identities = 11/31 (35%), Positives = 18/31 (58%)
Query: 57 GLHPFVRTEAWKFLTGYFSWQSSQDERLTVD 87
G+ P +R W FL G++ + ++ ER VD
Sbjct: 617 GIQPEIRKAVWPFLLGHYQFGMTETERKEVD 647
>gi|40068063 TBC1 domain family, member 22B [Homo sapiens]
Length = 505
Score = 38.1 bits (87), Expect = 0.011
Identities = 52/253 (20%), Positives = 100/253 (39%), Gaps = 33/253 (13%)
Query: 62 VRTEAWKFLTGYFSWQSSQDERLTVDSMRRKNYKALCQMYEKIQPLLENLHRNFTETRNN 121
VR W+ L+GY +++ +LT+ R + + + Q Y+ E H+ +T
Sbjct: 215 VRPITWRLLSGYLP-ANTERRKLTLQRKREEYFGFIEQYYDSRN---EEHHQ---DTYRQ 267
Query: 122 IARDIQKIYDKDPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQLM-----V 176
I DI + PL + ++ E+IL + + + + Y QG ++++ F ++ V
Sbjct: 268 IHIDIPRTNPLIPLFQQPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYV 327
Query: 177 EHDHE------------------TFWLFQFFLQKTEHSCVI-NIGVAKNLDMLSTLITFL 217
E D E +FW L + + G+ K + L L++ +
Sbjct: 328 EEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRI 387
Query: 218 DPVFAEHLKGKGAGAVQSLFPWFCFCFQRAFKSFDDVWRLWEVLLT-GKPCRNFQVLVAY 276
D H + +Q F W R + RLW+ + + +F + V
Sbjct: 388 DEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTI-RLWDTYQSEPEGFSHFHLYVCA 446
Query: 277 SMLQMVREQVLQE 289
+ L R+++L E
Sbjct: 447 AFLIKWRKEILDE 459
>gi|22507409 TBC1 domain family, member 22A [Homo sapiens]
Length = 517
Score = 36.6 bits (83), Expect = 0.033
Identities = 56/275 (20%), Positives = 107/275 (38%), Gaps = 40/275 (14%)
Query: 57 GLHPFVRTEAWKFLTGYFSWQSSQDERLTVDSMRRKNYKALCQMYEKIQPLLENLHRNFT 116
G+ VR WK L+GY ++ D R ++K Y A + Y + + +H+
Sbjct: 222 GIPKPVRPMTWKLLSGYLP--ANVDRRPATLQRKQKEYFAFIEHYYDSRN--DEVHQ--- 274
Query: 117 ETRNNIARDIQKIYDKDPLGNVLIDK--KRLEKILLLSYVCNTQAEYQQGFHEMMMLF-- 172
+T I DI ++ P +L K + E+IL + + + + Y QG ++++ F
Sbjct: 275 DTYRQIHIDIPRM---SPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFV 331
Query: 173 ----------------------QLMVEHDHETFWLFQFFLQKTEHSCVI-NIGVAKNLDM 209
+++ + +T+W L + + G+ + M
Sbjct: 332 VFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKM 391
Query: 210 LSTLITFLDPVFAEHLKGKGAGAVQSLFPWFCFCFQRAFKSFDDVWRLWEVLLTGKP-CR 268
L L++ +D HL +Q F W R + RLW+ +
Sbjct: 392 LEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTI-RLWDTYQSEPDGFS 450
Query: 269 NFQVLVAYSMLQMVREQVLQESMGGDDILLACNNL 303
+F + V + L R+++L+E ++LL NL
Sbjct: 451 HFHLYVCAAFLVRWRKEILEEK-DFQELLLFLQNL 484
>gi|190014603 TBC1 domain family, member 13 [Homo sapiens]
Length = 400
Score = 34.7 bits (78), Expect = 0.12
Identities = 39/159 (24%), Positives = 58/159 (36%), Gaps = 16/159 (10%)
Query: 145 LEKILLLSYVCNTQAEYQQGFHEMMMLFQLMVEHDHETFWL----FQFFLQKTEHSCVIN 200
+E+IL + N Y QG +E++ D + W F T I
Sbjct: 211 VERILFIYAKLNPGIAYVQGMNEIVGPLYYTFATDPNSEWKEHAEADTFFCFTNLMAEIR 270
Query: 201 IGVAKNLDMLSTLITFLDPVFAEHLKGKGAGAVQSL-----------FPWFCFCFQRAFK 249
K+LD IT+ LK K L F W + F
Sbjct: 271 DNFIKSLDDSQCGITYKMEKVYSTLKDKDVELYLKLQEQNIKPQFFAFRWLTLLLSQEFL 330
Query: 250 SFDDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQVLQ 288
DV R+W+ L +F +LV +ML ++REQ+L+
Sbjct: 331 -LPDVIRIWDSLFADDNRFDFLLLVCCAMLMLIREQLLE 368
>gi|223633919 hypothetical protein LOC285550 [Homo sapiens]
Length = 657
Score = 31.2 bits (69), Expect = 1.4
Identities = 13/47 (27%), Positives = 30/47 (63%), Gaps = 1/47 (2%)
Query: 163 QGFHEMMMLFQLMVEHDHETFWLFQFFLQKTEHSCVINIGVAKNLDM 209
QGF + ++L+Q+ ++ + ++++F FLQ E + +IN + K + +
Sbjct: 461 QGFRKTLLLWQVRLKSNRPSYYMFPRFLQHIEEN-IINENILKEIKL 506
>gi|11863130 phosphatidylinositol N-acetylglucosaminyltransferase
subunit A isoform 1 [Homo sapiens]
Length = 484
Score = 30.4 bits (67), Expect = 2.3
Identities = 18/57 (31%), Positives = 30/57 (52%), Gaps = 2/57 (3%)
Query: 95 KALCQMYEKIQPLLENLHRNFTE--TRNNIARDIQKIYDKDPLGNVLIDKKRLEKIL 149
KA+ Q+ P EN+H T N+A +K+YD+ + VL KRL++++
Sbjct: 361 KAIFQLKSGTLPAPENIHNIVKTFYTWRNVAERTEKVYDRVSVEAVLPMDKRLDRLI 417
>gi|110224463 phosphatidylinositol N-acetylglucosaminyltransferase
subunit A isoform 3 [Homo sapiens]
Length = 169
Score = 30.4 bits (67), Expect = 2.3
Identities = 18/57 (31%), Positives = 30/57 (52%), Gaps = 2/57 (3%)
Query: 95 KALCQMYEKIQPLLENLHRNFTE--TRNNIARDIQKIYDKDPLGNVLIDKKRLEKIL 149
KA+ Q+ P EN+H T N+A +K+YD+ + VL KRL++++
Sbjct: 46 KAIFQLKSGTLPAPENIHNIVKTFYTWRNVAERTEKVYDRVSVEAVLPMDKRLDRLI 102
>gi|197304777 TBC1 domain family, member 5 isoform a [Homo sapiens]
Length = 817
Score = 30.0 bits (66), Expect = 3.0
Identities = 17/67 (25%), Positives = 32/67 (47%)
Query: 117 ETRNNIARDIQKIYDKDPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQLMV 176
E R+ I +D+++ + + +K L +L N Q Y+QG HE++ ++
Sbjct: 158 ELRSMIEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVL 217
Query: 177 EHDHETF 183
DH+ F
Sbjct: 218 HCDHQAF 224
>gi|197304775 TBC1 domain family, member 5 isoform b [Homo sapiens]
Length = 795
Score = 30.0 bits (66), Expect = 3.0
Identities = 17/67 (25%), Positives = 32/67 (47%)
Query: 117 ETRNNIARDIQKIYDKDPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQLMV 176
E R+ I +D+++ + + +K L +L N Q Y+QG HE++ ++
Sbjct: 158 ELRSMIEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVL 217
Query: 177 EHDHETF 183
DH+ F
Sbjct: 218 HCDHQAF 224
>gi|7661998 TBC1 domain family, member 5 isoform b [Homo sapiens]
Length = 795
Score = 30.0 bits (66), Expect = 3.0
Identities = 17/67 (25%), Positives = 32/67 (47%)
Query: 117 ETRNNIARDIQKIYDKDPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQLMV 176
E R+ I +D+++ + + +K L +L N Q Y+QG HE++ ++
Sbjct: 158 ELRSMIEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVL 217
Query: 177 EHDHETF 183
DH+ F
Sbjct: 218 HCDHQAF 224
>gi|63047871 hypothetical protein LOC122525 [Homo sapiens]
Length = 310
Score = 29.6 bits (65), Expect = 4.0
Identities = 15/44 (34%), Positives = 21/44 (47%)
Query: 87 DSMRRKNYKALCQMYEKIQPLLENLHRNFTETRNNIARDIQKIY 130
D M ++ YK+ I L N H NFT+ N+ IQ+ Y
Sbjct: 111 DKMEKQQYKSEVHKASLIIDLFGNEHDNFTKNLENLMSTIQESY 154
>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
Length = 917
Score = 29.3 bits (64), Expect = 5.2
Identities = 28/124 (22%), Positives = 50/124 (40%), Gaps = 8/124 (6%)
Query: 144 RLEKILLLSYVCNTQAEYQQGFHEMMMLFQLMVEHDHETFWLFQFFLQ---KTEHSCVIN 200
+L ++LL N Y QG + + + L++E + FW ++ ++ C N
Sbjct: 694 KLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYC--N 751
Query: 201 IGVAKNLD--MLSTLITFLDPVFAEHLKGKGAGAVQSLFPWFCFCFQRAFKSFDDVWRLW 258
A +D +L L++ P HL F WF F + S + + R+W
Sbjct: 752 TLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLIS-NILLRVW 810
Query: 259 EVLL 262
+ L
Sbjct: 811 DAFL 814
>gi|28558969 mediator complex subunit 23 isoform b [Homo sapiens]
Length = 1365
Score = 29.3 bits (64), Expect = 5.2
Identities = 21/62 (33%), Positives = 34/62 (54%), Gaps = 9/62 (14%)
Query: 172 FQLMVEHDHETFWLFQFFLQKTEHSCVINIGVA-----KNLDMLSTLITFLDPV--FAEH 224
FQL+ + +L +F ++T C+I IGVA N+D ST + ++DP+ F H
Sbjct: 1249 FQLLYVYHLVGPFLQRFQQERTR--CMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYH 1306
Query: 225 LK 226
+K
Sbjct: 1307 MK 1308
>gi|28558971 mediator complex subunit 23 isoform a [Homo sapiens]
Length = 1368
Score = 29.3 bits (64), Expect = 5.2
Identities = 21/62 (33%), Positives = 34/62 (54%), Gaps = 9/62 (14%)
Query: 172 FQLMVEHDHETFWLFQFFLQKTEHSCVINIGVA-----KNLDMLSTLITFLDPV--FAEH 224
FQL+ + +L +F ++T C+I IGVA N+D ST + ++DP+ F H
Sbjct: 1243 FQLLYVYHLVGPFLQRFQQERTR--CMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYH 1300
Query: 225 LK 226
+K
Sbjct: 1301 MK 1302
>gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]
Length = 971
Score = 29.3 bits (64), Expect = 5.2
Identities = 23/96 (23%), Positives = 48/96 (50%), Gaps = 3/96 (3%)
Query: 54 LERGLHPFVRTEAWKFLTGYFSWQSSQDERLTVDSMRRKNYKALCQMYEKIQPLLENLHR 113
LE+ ++ RT+ + + QS +E +T + + K L ++ K +E +H
Sbjct: 322 LEKKVNEAKRTQQEYYERELKNLQSRLEEEVT--QLNEAHSKTLEELAWKHHMAIEAVHS 379
Query: 114 NFTETRNNIARDIQKIYDKDPLGNVLIDKKRLEKIL 149
N + + D+++ ++KD L N+ DK +L++ L
Sbjct: 380 NAIRDKKKLQMDLEEQHNKDKL-NLEEDKNQLQQEL 414
>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
Length = 1140
Score = 29.3 bits (64), Expect = 5.2
Identities = 23/96 (23%), Positives = 48/96 (50%), Gaps = 3/96 (3%)
Query: 54 LERGLHPFVRTEAWKFLTGYFSWQSSQDERLTVDSMRRKNYKALCQMYEKIQPLLENLHR 113
LE+ ++ RT+ + + QS +E +T + + K L ++ K +E +H
Sbjct: 442 LEKKVNEAKRTQQEYYERELKNLQSRLEEEVT--QLNEAHSKTLEELAWKHHMAIEAVHS 499
Query: 114 NFTETRNNIARDIQKIYDKDPLGNVLIDKKRLEKIL 149
N + + D+++ ++KD L N+ DK +L++ L
Sbjct: 500 NAIRDKKKLQMDLEEQHNKDKL-NLEEDKNQLQQEL 534
>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
Length = 446
Score = 29.3 bits (64), Expect = 5.2
Identities = 18/61 (29%), Positives = 29/61 (47%), Gaps = 1/61 (1%)
Query: 203 VAKNLDMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWFCFCFQRAFKSFDDVWRLWEVLL 262
V + ++ L+ L P +HL+ G G + L WF F R+ F V R+W+ L
Sbjct: 219 VRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSL-PFPTVLRVWDAFL 277
Query: 263 T 263
+
Sbjct: 278 S 278
>gi|5032281 dystrophin Dp427c isoform [Homo sapiens]
Length = 3677
Score = 28.9 bits (63), Expect = 6.8
Identities = 15/56 (26%), Positives = 27/56 (48%), Gaps = 1/56 (1%)
Query: 208 DMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWFCFCFQRAFKSFDDVWRLWEVLLT 263
+ ++++I PV E LK K + + + W C K+ ++VW W LL+
Sbjct: 1211 ESVNSVIAQAPPVAQEALK-KELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLS 1265
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.138 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,079,382
Number of Sequences: 37866
Number of extensions: 485847
Number of successful extensions: 1391
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 12
Number of HSP's successfully gapped in prelim test: 27
Number of HSP's that attempted gapping in prelim test: 1353
Number of HSP's gapped (non-prelim): 50
length of query: 336
length of database: 18,247,518
effective HSP length: 103
effective length of query: 233
effective length of database: 14,347,320
effective search space: 3342925560
effective search space used: 3342925560
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.