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Search of human proteins with 23312388
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
(412 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens] 862 0.0
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H... 803 0.0
gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens] 661 0.0
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ... 259 4e-69
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens] 249 2e-66
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens] 247 1e-65
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec... 245 6e-65
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens] 232 4e-61
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi... 232 4e-61
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [... 229 3e-60
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec... 226 2e-59
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec... 225 6e-59
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre... 225 6e-59
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec... 208 6e-54
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [... 194 2e-49
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens] 188 7e-48
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr... 180 2e-45
gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p... 152 7e-37
gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ... 148 8e-36
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform... 139 4e-33
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform... 139 4e-33
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform... 124 2e-28
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens] 105 1e-22
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens] 104 1e-22
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor... 96 8e-20
gi|223468705 5-hydroxytryptamine receptor 3 subunit D isoform 1 ... 57 2e-08
gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1 p... 56 7e-08
gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precurso... 55 2e-07
gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3 is... 55 2e-07
gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3 iso... 55 2e-07
>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
Length = 412
Score = 862 bits (2228), Expect = 0.0
Identities = 412/412 (100%), Positives = 412/412 (100%)
Query: 1 MQKYCIYQHFQFQLLIQHLWIAANCDIADERFDATFHTNVLVNSSGHCQYLPPGIFKSSC 60
MQKYCIYQHFQFQLLIQHLWIAANCDIADERFDATFHTNVLVNSSGHCQYLPPGIFKSSC
Sbjct: 1 MQKYCIYQHFQFQLLIQHLWIAANCDIADERFDATFHTNVLVNSSGHCQYLPPGIFKSSC 60
Query: 61 YIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFY 120
YIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFY
Sbjct: 61 YIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFY 120
Query: 121 ECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLL 180
ECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLL
Sbjct: 121 ECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLL 180
Query: 181 SLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKW 240
SLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKW
Sbjct: 181 SLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKW 240
Query: 241 TRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFR 300
TRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFR
Sbjct: 241 TRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFR 300
Query: 301 GLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQ 360
GLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQ
Sbjct: 301 GLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQ 360
Query: 361 DESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA 412
DESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
Sbjct: 361 DESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA 412
>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
sapiens]
Length = 502
Score = 803 bits (2074), Expect = 0.0
Identities = 385/385 (100%), Positives = 385/385 (100%)
Query: 28 ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWS 87
ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWS
Sbjct: 118 ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWS 177
Query: 88 LDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNL 147
LDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNL
Sbjct: 178 LDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNL 237
Query: 148 LIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYF 207
LIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYF
Sbjct: 238 LIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYF 297
Query: 208 ASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPAC 267
ASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPAC
Sbjct: 298 ASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPAC 357
Query: 268 QHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHD 327
QHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHD
Sbjct: 358 QHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHD 417
Query: 328 EHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSV 387
EHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSV
Sbjct: 418 EHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSV 477
Query: 388 FTIICTIGILMSAPNFVEAVSKDFA 412
FTIICTIGILMSAPNFVEAVSKDFA
Sbjct: 478 FTIICTIGILMSAPNFVEAVSKDFA 502
>gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
Length = 321
Score = 661 bits (1705), Expect = 0.0
Identities = 321/321 (100%), Positives = 321/321 (100%)
Query: 92 MQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPC 151
MQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPC
Sbjct: 1 MQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPC 60
Query: 152 VLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTM 211
VLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTM
Sbjct: 61 VLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTM 120
Query: 212 IIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQ 271
IIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQ
Sbjct: 121 IIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQ 180
Query: 272 RRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLL 331
RRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLL
Sbjct: 181 RRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLL 240
Query: 332 HGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTII 391
HGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTII
Sbjct: 241 HGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTII 300
Query: 392 CTIGILMSAPNFVEAVSKDFA 412
CTIGILMSAPNFVEAVSKDFA
Sbjct: 301 CTIGILMSAPNFVEAVSKDFA 321
>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
(neuronal) [Homo sapiens]
Length = 529
Score = 259 bits (661), Expect = 4e-69
Identities = 150/394 (38%), Positives = 211/394 (53%), Gaps = 46/394 (11%)
Query: 28 ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWS 87
AD F T T + S+G ++PP I+KSSC IDV +FPFD Q+CK+KFGSW+Y
Sbjct: 151 ADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAK 210
Query: 88 LDLQMQE--ADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGL 145
+DL+ E D+ Y +GEW +V G + + Y+CC E YPDVT+ +RR L+Y +
Sbjct: 211 IDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTI 270
Query: 146 NLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQ 205
NL+IPC+LIS L +LVF LP+D GEKI+L I+VLLSLTVF+LL+ EI+P+TS +PLI +
Sbjct: 271 NLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGE 330
Query: 206 YFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGED---- 261
Y TMI V LS+V+TV VL HH P MP W R LL +L M RP
Sbjct: 331 YLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELC 390
Query: 262 ---KVRPACQHKQRRCSLASVEMSAVAPPP---ASNGNLLYIGFRGLDGVHCVPTPDSGV 315
+++ + + ++ + E V A G++ P G
Sbjct: 391 HPLRLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHV---------------APSVGT 435
Query: 316 VCGRMACSPTHDEHLLHGGQPPEGD-----------PDLAKILEEVRYIANRFRCQDESE 364
+C HL G P+ + P + K LE V YIA+ R +D
Sbjct: 436 LCSH--------GHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADS 487
Query: 365 AVCSEWKFAACVVDRLCLMAFSVFTIICTIGILM 398
+V +WK+ A V+DR+ L F + + TIG+ +
Sbjct: 488 SVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFL 521
>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
Length = 505
Score = 249 bits (637), Expect = 2e-66
Identities = 137/375 (36%), Positives = 214/375 (57%), Gaps = 17/375 (4%)
Query: 32 FDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQ 91
F T L+ +G ++PP IFKSSC IDV +FPFD Q+C +KFGSWSY +DL
Sbjct: 131 FQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLV 190
Query: 92 M--QEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLI 149
+ ++ Y +GEW ++ PG + + Y CC+E YPD+T+++ +RR L+Y +NL+I
Sbjct: 191 LIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLII 250
Query: 150 PCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAS 209
PC+LIS L +LVF LP+D GEK++L I+VLLSLTVF+L++ E +P+TS +PLI +Y
Sbjct: 251 PCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLF 310
Query: 210 TMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQH 269
TMI V LS+V+TV VL H+ P MP W + + LN + M RP ++ +
Sbjct: 311 TMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNE-----GN 365
Query: 270 KQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGV--HC----VPTPDSGVVCGRMACS 323
Q+ L E+S + + G+ DG+ +C + + R + S
Sbjct: 366 AQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSS 425
Query: 324 PTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLM 383
+ D L PE + + ++ V+YIA + Q+E++ + +WK+ A V+DR+ L
Sbjct: 426 ESVDAVLSLSALSPE----IKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLW 481
Query: 384 AFSVFTIICTIGILM 398
F++ I+ T G+ +
Sbjct: 482 VFTLVCILGTAGLFL 496
>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
Length = 498
Score = 247 bits (631), Expect = 1e-65
Identities = 140/377 (37%), Positives = 215/377 (57%), Gaps = 24/377 (6%)
Query: 28 ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWS 87
AD ++ + +TN++V S+G +LPP I+KS+C I+V++FPFD Q+C LKF SW+Y
Sbjct: 121 ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE 180
Query: 88 LDLQMQE--ADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGL 145
+D+ + A + + P+GEWD+V +PG+R+ + Y DVT+ ++R+ L+Y +
Sbjct: 181 IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQD---PSYVDVTYDFIIKRKPLFYTI 237
Query: 146 NLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQ 205
NL+IPCVL + LA+LVF LP+D GEK++L I+VLL+LT F+LL+++I+P TS VPLI +
Sbjct: 238 NLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGK 297
Query: 206 YFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRP 265
Y TM++V S+V +V VL HH P M W + L+ FL MKRPG D P
Sbjct: 298 YLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDS-SP 356
Query: 266 ACQHKQRRCSLASVEMSAVAPPPAS-NGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSP 324
A + + E +A + P++ GN +Y P S +P
Sbjct: 357 ARAFPPSKSCVTKPEATATSTSPSNFYGNSMYF-----------VNPASAASKSPAGSTP 405
Query: 325 T---HDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLC 381
D L G+ + D+ + LE V +IA + DE ++V +WK+ A VVDRL
Sbjct: 406 VAIPRDFWLRSSGRFRQ---DVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLF 462
Query: 382 LMAFSVFTIICTIGILM 398
L F ++ T+G+ +
Sbjct: 463 LWVFMFVCVLGTVGLFL 479
>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
precursor [Homo sapiens]
Length = 502
Score = 245 bits (625), Expect = 6e-65
Identities = 133/389 (34%), Positives = 219/389 (56%), Gaps = 26/389 (6%)
Query: 17 QHLWI--AANCDIADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHC 74
+H+W+ + AD ++ +F++N +V+ G +LPP I+KS+C I+V+ FPFD Q+C
Sbjct: 110 KHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNC 169
Query: 75 KLKFGSWSYGGWSLDLQMQE--ADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTF 132
+KF SW+Y +DL ++ A + + P+GEWD+V +PG+R+E + Y D+T+
Sbjct: 170 TMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDD---STYVDITY 226
Query: 133 TVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEI 192
+RR+ L+Y +NL+IPCVLI++LA+LVF LP+D GEK++L I+VLL+LTVF+LL+++I
Sbjct: 227 DFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKI 286
Query: 193 MPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWF 252
+P TS VPL+ +Y TM++V S+V +V VL HH P M W +V+ L
Sbjct: 287 VPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPAL 346
Query: 253 LRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPD 312
L M++P R + ++R+ P ++ ++ + G
Sbjct: 347 LFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQG-------- 398
Query: 313 SGVVCGRMACSPTHDEHLLHGGQPPEGDP---DLAKILEEVRYIANRFRCQDESEAVCSE 369
+ G P G G+P L + ++ VR+IA+ R +D+ ++V +
Sbjct: 399 ---LAGAFGAEPAP-----VAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSED 450
Query: 370 WKFAACVVDRLCLMAFSVFTIICTIGILM 398
WK+ A V+DRL L F + TIG+ +
Sbjct: 451 WKYVAMVIDRLFLWIFVFVCVFGTIGMFL 479
>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
Length = 494
Score = 232 bits (592), Expect = 4e-61
Identities = 130/376 (34%), Positives = 205/376 (54%), Gaps = 30/376 (7%)
Query: 32 FDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQ 91
F T L+ +G + PP IFKSSC +D+ +FPFD Q+C LKFGSW+Y +DL
Sbjct: 130 FQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLL 189
Query: 92 M--QEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLI 149
+ + D++ + N EW+++ G + + Y CC+E Y D+T++ +RR ++Y +NL+I
Sbjct: 190 IIGSKVDMNDFWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLII 249
Query: 150 PCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAS 209
PC+ IS L +LVF LP+D GEK++L I+VLLSLTVF+L++ E +P+TS VPL+ +Y
Sbjct: 250 PCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLF 309
Query: 210 TMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRP-------GEDK 262
TMI V LS+VVTV VL H+ P MP+W + + L L M+ P G D
Sbjct: 310 TMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDA 369
Query: 263 VRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMAC 322
V + + L AS+G ++ + HC + + R++
Sbjct: 370 VPRGLARRPAKGKL------------ASHGEPRHL----KECFHCHKSNELATSKRRLSH 413
Query: 323 SPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCL 382
P L + E P++ ++ V++IA + +E++ V +WK+ A VVDR+ L
Sbjct: 414 QP-----LQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFL 468
Query: 383 MAFSVFTIICTIGILM 398
F + + T G+ +
Sbjct: 469 WVFIIVCVFGTAGLFL 484
>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
sapiens]
Length = 450
Score = 232 bits (592), Expect = 4e-61
Identities = 141/375 (37%), Positives = 199/375 (53%), Gaps = 49/375 (13%)
Query: 28 ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWS 87
AD + + TNV++ G ++ P I +SSC +DV FPFD QHC L FGSW++GG
Sbjct: 122 ADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQ 181
Query: 88 LDLQMQ--EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGL 145
LD++ + A ++ ++ N EW ++G+P +R Y CC EPYPDVTFT+ +RRR Y
Sbjct: 182 LDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVC 241
Query: 146 NLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQ 205
NLL+PCVLIS LA L F LPADSGEK+SLG+TVLL+LTVF LL+AE MP ++SVPLI +
Sbjct: 242 NLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMP-PAESVPLIGK 300
Query: 206 YFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRP 265
Y+ +TM +V S +T++++ H+ P +P W R +LL A L ++ GE P
Sbjct: 301 YYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGE----P 356
Query: 266 ACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPT 325
Q + S + A PPA P + +C
Sbjct: 357 CGQSRPPELSPSPQSPEGGAGPPAG------------------PCHEPRCLC-------- 390
Query: 326 HDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAF 385
E LLH V IAN FR ++ +WK A V+DR L F
Sbjct: 391 RQEALLH----------------HVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIF 434
Query: 386 SVFTIICTIGILMSA 400
++ ++ +L+ A
Sbjct: 435 FSMALVMSLLVLVQA 449
>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
[Homo sapiens]
Length = 479
Score = 229 bits (584), Expect = 3e-60
Identities = 137/386 (35%), Positives = 206/386 (53%), Gaps = 43/386 (11%)
Query: 28 ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWS 87
AD+ +TNV++ G + P I KSSC +DV +FPFD Q C L FGSW+Y G
Sbjct: 123 ADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQ 182
Query: 88 LDL--QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGL 145
+D+ + D+S +I + EW++ G+P ++ Y CC EPYPDVTFT+ ++RR+ +Y +
Sbjct: 183 VDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIV 242
Query: 146 NLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQ 205
NLLIPCVLIS LA L F LPA SGEK+SLG+T+LL++TVF L+VAEIMPA S++VPLI +
Sbjct: 243 NLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPA-SENVPLIGK 301
Query: 206 YFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRP 265
Y+ +TM ++ S +T++V+ H + +P W RV++L + + L + GE + P
Sbjct: 302 YYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLSP 361
Query: 266 ACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGR---MAC 322
H + R L V P+S + R ++
Sbjct: 362 --HHSRERDHLTKVYSK---------------------------LPESNLKAARNKDLSR 392
Query: 323 SPTHDEHL-----LHGGQPPEGDPDLAK---ILEEVRYIANRFRCQDESEAVCSEWKFAA 374
++ L G P E + A+ + + YIA + + + SEWK A
Sbjct: 393 KKDMNKRLKNDLGCQGKNPQEAESYCAQYKVLTRNIEYIAKCLKDHKATNSKGSEWKKVA 452
Query: 375 CVVDRLCLMAFSVFTIICTIGILMSA 400
V+DR + F + + TI I+ A
Sbjct: 453 KVIDRFFMWIFFIMVFVMTILIIARA 478
>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
precursor [Homo sapiens]
Length = 627
Score = 226 bits (577), Expect = 2e-59
Identities = 121/269 (44%), Positives = 160/269 (59%), Gaps = 4/269 (1%)
Query: 28 ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWS 87
AD F T T + G Q+ PP I+KSSC IDV +FPFD Q+C +KFGSW+Y
Sbjct: 129 ADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAK 188
Query: 88 LDL--QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGL 145
+DL D + +GEW +V G + R YECC E YPD+T+ +RR L+Y +
Sbjct: 189 IDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTI 248
Query: 146 NLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQ 205
NL+IPC+LIS L +LVF LP++ GEKI+L I+VLLSLTVF+LL+ EI+P+TS +PLI +
Sbjct: 249 NLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGE 308
Query: 206 YFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPG--EDKV 263
Y TMI V LS+V+TV VL HH P MP W R + L+ L MKRP +D
Sbjct: 309 YLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNC 368
Query: 264 RPACQHKQRRCSLASVEMSAVAPPPASNG 292
R + + S PPA++G
Sbjct: 369 RRLIESMHKMASAPRFWPEPEGEPPATSG 397
Score = 47.4 bits (111), Expect = 2e-05
Identities = 19/58 (32%), Positives = 36/58 (62%)
Query: 341 PDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILM 398
P L + +E V+YIA+ + +D +V +WK+ A V+DR+ L F + ++ T+G+ +
Sbjct: 562 PALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL 619
>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
precursor [Homo sapiens]
Length = 457
Score = 225 bits (573), Expect = 6e-59
Identities = 131/380 (34%), Positives = 201/380 (52%), Gaps = 62/380 (16%)
Query: 28 ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGW- 86
AD F T VL+ +GH + PP IFKS C I V FPFD Q+C +K G+W+Y G
Sbjct: 116 ADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSV 175
Query: 87 -SLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKE-PYPDVTFTVTMRRRTLYYG 144
+++ + + D+S ++ +GEW + G + Y CC + PY D+T+ M+R LY+
Sbjct: 176 VAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFI 235
Query: 145 LNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIA 204
+N++IPC+L S L LVF LP DSGEK++L I+VLLSLTVF+L++ E++P+TS +VPLI
Sbjct: 236 VNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIG 295
Query: 205 QYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNW---CAWFLRMKRPGED 261
+Y TM+ V S+++TVIV+ HH P MP W R + ++ +F MKRP +
Sbjct: 296 KYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSRE 355
Query: 262 KVRPACQHKQRRCSLASVEMSAVA----PPPASNGNLLYIGFRGLDGVHCVPTPDSGVVC 317
K + ++ +++S ++ PPP +GF
Sbjct: 356 K-------QDKKIFTEDIDISDISGKPGPPP--------MGF------------------ 382
Query: 318 GRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVV 377
H + H P++ +E ++YIA + ES +EWK+ A V+
Sbjct: 383 --------HSPLIKH--------PEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVM 426
Query: 378 DRLCLMAFSVFTIICTIGIL 397
D + L VF ++C IG L
Sbjct: 427 DHILL---GVFMLVCIIGTL 443
>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
precursor [Homo sapiens]
Length = 482
Score = 225 bits (573), Expect = 6e-59
Identities = 131/380 (34%), Positives = 201/380 (52%), Gaps = 62/380 (16%)
Query: 28 ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGW- 86
AD F T VL+ +GH + PP IFKS C I V FPFD Q+C +K G+W+Y G
Sbjct: 141 ADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSV 200
Query: 87 -SLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKE-PYPDVTFTVTMRRRTLYYG 144
+++ + + D+S ++ +GEW + G + Y CC + PY D+T+ M+R LY+
Sbjct: 201 VAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFI 260
Query: 145 LNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIA 204
+N++IPC+L S L LVF LP DSGEK++L I+VLLSLTVF+L++ E++P+TS +VPLI
Sbjct: 261 VNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIG 320
Query: 205 QYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNW---CAWFLRMKRPGED 261
+Y TM+ V S+++TVIV+ HH P MP W R + ++ +F MKRP +
Sbjct: 321 KYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSRE 380
Query: 262 KVRPACQHKQRRCSLASVEMSAVA----PPPASNGNLLYIGFRGLDGVHCVPTPDSGVVC 317
K + ++ +++S ++ PPP +GF
Sbjct: 381 K-------QDKKIFTEDIDISDISGKPGPPP--------MGF------------------ 407
Query: 318 GRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVV 377
H + H P++ +E ++YIA + ES +EWK+ A V+
Sbjct: 408 --------HSPLIKH--------PEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVM 451
Query: 378 DRLCLMAFSVFTIICTIGIL 397
D + L VF ++C IG L
Sbjct: 452 DHILL---GVFMLVCIIGTL 468
>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
precursor [Homo sapiens]
Length = 501
Score = 208 bits (530), Expect = 6e-54
Identities = 134/400 (33%), Positives = 207/400 (51%), Gaps = 57/400 (14%)
Query: 29 DERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSL 88
D FD +V+V+S G ++ PPGI++SSC I V +FPFD Q+C + F S+SY +
Sbjct: 120 DGNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEV 179
Query: 89 DLQM---------QEADI--SGYIPNGEWDLVGIPGKRSERFYECCKEPY-------PDV 130
LQ QE I +I NG+W+++ P R + +P +V
Sbjct: 180 SLQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPS----RLIQPPGDPRGGREGQRQEV 235
Query: 131 TFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVA 190
F + +RR+ L+Y +N++ PC+LI+ LA+ VF LP D+GEK+ L I LL+LTVF+LL+A
Sbjct: 236 IFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLA 295
Query: 191 EIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCA 250
+ +P TS SVP+I +Y TM++V SV+++V+VL HH P +MP W R I ++
Sbjct: 296 DKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLP 355
Query: 251 WFLRMKRPGEDK----VRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVH 306
+LR+KRP ++ P C + E PP + L+
Sbjct: 356 LYLRLKRPKPERDLMPEPPHCSSPGSGWGRGTDEYFIRKPP----SDFLF---------- 401
Query: 307 CVPTPD------SGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQ 360
P P+ S R P LL P+L +++ + YIA + + Q
Sbjct: 402 --PKPNRFQPELSAPDLRRFIDGPNRAVALL---------PELREVVSSISYIARQLQEQ 450
Query: 361 DESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSA 400
++ +A+ +W+F A VVDRL L F +FT + T+ I + A
Sbjct: 451 EDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVIFLDA 490
>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
[Homo sapiens]
Length = 458
Score = 194 bits (492), Expect = 2e-49
Identities = 122/379 (32%), Positives = 187/379 (49%), Gaps = 56/379 (14%)
Query: 28 ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWS 87
AD RF+ + T V+V S+G + PP +KSSC +DV +FPFD Q+C +KFGSW+Y G
Sbjct: 121 ADGRFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTM 180
Query: 88 LDLQM--QEADISGYIPNGEWDLV---GIPGKRSERFYECCKEPYPDVTFTVTMRRRTLY 142
+DL + + D + NGEW+++ G+ G R + Y YP +T++ +RR L+
Sbjct: 181 VDLILINENVDRKDFFDNGEWEILNAKGMKGNRRDGVYS-----YPFITYSFVLRRLPLF 235
Query: 143 YGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPL 202
Y L L+IPC+ +S L +LVF LP+D GEK+SL +VL+SLTVF+L++ EI+P++S +PL
Sbjct: 236 YTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPL 295
Query: 203 IAQYFASTMIIVGLSVVVTVIVLQYHHHDPDG-GKMPKWTRVILLNWCAWFLRMKRPGED 261
I +Y MI V LS++VTV V+ HH M W + + L L MK +
Sbjct: 296 IGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDR 355
Query: 262 KVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMA 321
P + Q +E S+G + + F
Sbjct: 356 YSSPEKEESQPVVKGKVLEKK--KQKQLSDGEKVLVAF---------------------- 391
Query: 322 CSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLC 381
L K + +RYI+ + + V +WKF A V+DR+
Sbjct: 392 ---------------------LEKAADSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIF 430
Query: 382 LMAFSVFTIICTIGILMSA 400
L F + ++ ++ I A
Sbjct: 431 LWLFLIVSVTGSVLIFTPA 449
>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
Length = 468
Score = 188 bits (478), Expect = 7e-48
Identities = 92/206 (44%), Positives = 137/206 (66%), Gaps = 5/206 (2%)
Query: 26 DIADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGG 85
D AD RF+ T T ++ +G + PP +KSSC IDV +FPFD+Q+C +KFGSW+Y G
Sbjct: 137 DNADGRFEGT-STKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDG 195
Query: 86 WSLDLQMQEADIS--GYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYY 143
+D+ +++ D+ + NGEW++V G + R CC PY VT++ ++R L+Y
Sbjct: 196 SQVDIILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPY--VTYSFVIKRLPLFY 253
Query: 144 GLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLI 203
L L+IPC+ +S L +LVF LP++ GEKI L +VL+SLTVF+L++ EI+P++S +PLI
Sbjct: 254 TLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLI 313
Query: 204 AQYFASTMIIVGLSVVVTVIVLQYHH 229
+Y TMI V LS++VTV + HH
Sbjct: 314 GEYLVFTMIFVTLSIMVTVFAINIHH 339
Score = 42.4 bits (98), Expect = 8e-04
Identities = 21/74 (28%), Positives = 35/74 (47%)
Query: 325 THDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMA 384
T E G P L L+ +RYI +++ V +WKF A V+DR+ L
Sbjct: 375 TQKEETESGSGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWT 434
Query: 385 FSVFTIICTIGILM 398
F +I+ ++G+ +
Sbjct: 435 FLFVSIVGSLGLFV 448
>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
precursor [Homo sapiens]
Length = 517
Score = 180 bits (456), Expect = 2e-45
Identities = 123/385 (31%), Positives = 185/385 (48%), Gaps = 29/385 (7%)
Query: 29 DERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSL 88
D F ++ NVLV G +LPP IF+SSC I V +FPFD Q+C LKF S Y +
Sbjct: 120 DGSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEI 179
Query: 89 DLQMQE--------------ADISGYIPNGEWDLVGIPGKRSERFYECCKEPY-PDVTFT 133
L +++ D G+ NGEW++V P + + P D+TF
Sbjct: 180 TLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFY 239
Query: 134 VTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIM 193
+ +RR+ L+Y +N+L+PCVLIS + LVF LPADSGEK S+ I+VLL+ +VF+LL+++ +
Sbjct: 240 LIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRL 299
Query: 194 PATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFL 253
PATS ++PLI ++ M++V + VV+ VIVL H P + + + + L L
Sbjct: 300 PATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELL 359
Query: 254 RMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDS 313
M RP ED P +R SL + + S +L++ G+ T
Sbjct: 360 HMSRPAEDGPSPGAL-VRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLT--- 415
Query: 314 GVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFA 373
R S + L +L ++ +I N R Q+ W
Sbjct: 416 --TARRPPASSEQAQQELFN--------ELKPAVDGANFIVNHMRDQNNYNEEKDSWNRV 465
Query: 374 ACVVDRLCLMAFSVFTIICTIGILM 398
A VDRLCL + ++ T I +
Sbjct: 466 ARTVDRLCLFVVTPVMVVGTAWIFL 490
>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
precursor [Homo sapiens]
Length = 517
Score = 152 bits (383), Expect = 7e-37
Identities = 120/398 (30%), Positives = 181/398 (45%), Gaps = 47/398 (11%)
Query: 29 DERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSL 88
D F+ + NVLV+ G +LPP IF+S+C I V +FPFD Q+C L F S +Y +
Sbjct: 119 DGVFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEI 178
Query: 89 DLQMQE----------ADISGYIPNGEWDLVGIPGKR-SERFYECCKEPYPDVTFTVTMR 137
DLQ+ + D + NGEW + P K + + + V F + ++
Sbjct: 179 DLQLSQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQ 238
Query: 138 RRTLYYGLNLLIPCVLISALALLVFLLPADS-GEKISLGITVLLSLTVFMLLVAEIMPAT 196
R+ L+Y +N++ PCVLIS++A+L+ LPA + G+K ++ I VLL+ TVF+ LVA+ +P T
Sbjct: 239 RKPLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPET 298
Query: 197 SDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMK 256
S +VPLI++Y +++ L VV V+VL P M + R + L LRM
Sbjct: 299 SQAVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRM- 357
Query: 257 RPGEDKVRP----ACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPD 312
VRP A Q Q R NG+ + G + C+P +
Sbjct: 358 -----HVRPLAPAAVQDTQSR---------------LQNGSSGWSITTGEEVALCLPRSE 397
Query: 313 --------SGVVCGRMACSPTHDEHLLHG--GQPPEGDPDLAKILEEVRYIANRFRCQDE 362
G+V + E L G + P + +E IA Q
Sbjct: 398 LLFQQWQRQGLVAAALEKLEKGPELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSH 457
Query: 363 SEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSA 400
+ EW V+DR+C +A I T GI + A
Sbjct: 458 FDNGNEEWFLVGRVLDRVCFLAMLSLFICGTAGIFLMA 495
>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
precursor [Homo sapiens]
Length = 493
Score = 148 bits (374), Expect = 8e-36
Identities = 111/387 (28%), Positives = 175/387 (45%), Gaps = 47/387 (12%)
Query: 29 DERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSL 88
D +F + NVLV G +LPP I++S C ++V +FPFD Q+C L F S +Y +
Sbjct: 117 DGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEV 176
Query: 89 DLQMQ-----------EADISGYIPNGEWDLVGIPGKRSERFYECCKEP-YPDVTFTVTM 136
+ + D Y NGEW + PG P DV +++ +
Sbjct: 177 EFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLII 236
Query: 137 RRRTLYYGLNLLIPCVLISALALLVFLLPADSG-EKISLGITVLLSLTVFMLLVAEIMPA 195
RR+ L+Y +N+++PCVLIS L LL + LPA +G +K ++ I VLL+ TVF+ L+A+ +P
Sbjct: 237 RRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPE 296
Query: 196 TSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRM 255
TS SVPL+ ++ M++ L V+ VIVL P M R +LL L
Sbjct: 297 TSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGS 356
Query: 256 KRPGEDKVRPACQHKQRRCSLASVEMSA---VAPPPASNGNLLYIGFRGLDGVHCVPTPD 312
P E P RR S + + A + P S L++ G R G
Sbjct: 357 PPPPE---APRAASPPRRASSVGLLLRAEELILKKPRS--ELVFEGQRHRQGTW------ 405
Query: 313 SGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKF 372
+ C + + P++ ++ V ++A R Q+ + S+W
Sbjct: 406 TAAFCQSLGAAA----------------PEVRCCVDAVNFVAESTRDQEATGEEVSDWVR 449
Query: 373 AACVVDRLC----LMAFSVFTIICTIG 395
+D +C L+ FSV + + +G
Sbjct: 450 MGNALDNICFWAALVLFSVGSSLIFLG 476
>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
precursor [Homo sapiens]
Length = 484
Score = 139 bits (351), Expect = 4e-33
Identities = 96/369 (26%), Positives = 171/369 (46%), Gaps = 45/369 (12%)
Query: 40 VLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQ------ 93
V + G Q P ++C +D+ FPFDVQ+C L F SW + +++ +
Sbjct: 143 VYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKV 202
Query: 94 EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVL 153
++D S ++ GEW+L+G+ E E Y ++ F V +RRR L+Y ++LL+P +
Sbjct: 203 KSDRSVFMNQGEWELLGVLPYFREFSMESSNY-YAEMKFYVVIRRRPLFYVVSLLLPSIF 261
Query: 154 ISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMII 213
+ + ++ F LP +SGE++S IT+LL +VF+++V++ +PAT+ PLI YF M +
Sbjct: 262 LMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMAL 321
Query: 214 VGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRR 273
+ +S+ T+ +++ H +P W R ++L AW L ++ + PA +
Sbjct: 322 LVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKT 381
Query: 274 CSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHC--VPTPDSGVVCGRMACSPTHDEHLL 331
+++ G HC + P R CSP
Sbjct: 382 DDCSAM------------------------GNHCSHMGGPQDFEKSPRDRCSPP------ 411
Query: 332 HGGQPPEGDPDLAK--ILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFT 389
PP + LA +L+E+ I +DE V +W V+D+L + +
Sbjct: 412 ----PPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAV 467
Query: 390 IICTIGILM 398
+ +I ++M
Sbjct: 468 LAYSITLVM 476
>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
[Homo sapiens]
Length = 463
Score = 139 bits (351), Expect = 4e-33
Identities = 96/369 (26%), Positives = 171/369 (46%), Gaps = 45/369 (12%)
Query: 40 VLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQ------ 93
V + G Q P ++C +D+ FPFDVQ+C L F SW + +++ +
Sbjct: 122 VYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKV 181
Query: 94 EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVL 153
++D S ++ GEW+L+G+ E E Y ++ F V +RRR L+Y ++LL+P +
Sbjct: 182 KSDRSVFMNQGEWELLGVLPYFREFSMESSNY-YAEMKFYVVIRRRPLFYVVSLLLPSIF 240
Query: 154 ISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMII 213
+ + ++ F LP +SGE++S IT+LL +VF+++V++ +PAT+ PLI YF M +
Sbjct: 241 LMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMAL 300
Query: 214 VGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRR 273
+ +S+ T+ +++ H +P W R ++L AW L ++ + PA +
Sbjct: 301 LVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKT 360
Query: 274 CSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHC--VPTPDSGVVCGRMACSPTHDEHLL 331
+++ G HC + P R CSP
Sbjct: 361 DDCSAM------------------------GNHCSHMGGPQDFEKSPRDRCSPP------ 390
Query: 332 HGGQPPEGDPDLAK--ILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFT 389
PP + LA +L+E+ I +DE V +W V+D+L + +
Sbjct: 391 ----PPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAV 446
Query: 390 IICTIGILM 398
+ +I ++M
Sbjct: 447 LAYSITLVM 455
>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
precursor [Homo sapiens]
Length = 516
Score = 124 bits (311), Expect = 2e-28
Identities = 96/401 (23%), Positives = 172/401 (42%), Gaps = 77/401 (19%)
Query: 40 VLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQ------ 93
V + G Q P ++C +D+ FPFDVQ+C L F SW + +++ +
Sbjct: 143 VYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKV 202
Query: 94 EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVL 153
++D S ++ GEW+L+G+ E E Y ++ F V +RRR L+Y ++LL+P +
Sbjct: 203 KSDRSVFMNQGEWELLGVLPYFREFSMESSNY-YAEMKFYVVIRRRPLFYVVSLLLPSIF 261
Query: 154 ISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQ-------- 205
+ + ++ F LP +SGE++S IT+LL +VF+++V++ +PAT+ PLI +
Sbjct: 262 LMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQ 321
Query: 206 ------------------------YFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWT 241
YF M ++ +S+ T+ +++ H +P W
Sbjct: 322 SGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWL 381
Query: 242 RVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRG 301
R ++L AW L ++ + PA + +++
Sbjct: 382 RHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAM---------------------- 419
Query: 302 LDGVHC--VPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLA--KILEEVRYIANRF 357
G HC + P R CSP PP + LA +L+E+ I
Sbjct: 420 --GNHCSHMGGPQDFEKSPRDRCSP----------PPPPREASLAVCGLLQELSSIRQFL 467
Query: 358 RCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILM 398
+DE V +W V+D+L + + + +I ++M
Sbjct: 468 EKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVM 508
>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
Length = 447
Score = 105 bits (261), Expect = 1e-22
Identities = 75/243 (30%), Positives = 121/243 (49%), Gaps = 13/243 (5%)
Query: 14 LLIQHLWIAANCDIADERFDAT-FHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQ 72
+L ++LW+ + D T ++S G +Y P S C +D+ +FPFD Q
Sbjct: 115 VLAENLWLPDIFIVESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQ 174
Query: 73 HCKLKFGSWSYGGWSLDLQMQE-----ADISGYI--PNGEWDLVGIPGKRSERFYECCKE 125
+C F S+ Y S+ L M + D S + GEW+L+GI ++
Sbjct: 175 NCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGI--NKATPKMSMGNN 232
Query: 126 PYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVF 185
Y + F V +RRR Y +NLL+P + A+ L F LPA+S + IT+LL VF
Sbjct: 233 LYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVF 292
Query: 186 MLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTV-IVLQYHHHDPDGGKMPKWTRVI 244
+L++ +++PA+ PLI+ YFA + ++ +S++ TV I H MP+W +
Sbjct: 293 LLMMNDLLPAS--GTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSL 350
Query: 245 LLN 247
LL+
Sbjct: 351 LLH 353
>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
Length = 471
Score = 104 bits (260), Expect = 1e-22
Identities = 67/214 (31%), Positives = 112/214 (52%), Gaps = 12/214 (5%)
Query: 42 VNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQE-----AD 96
V++ G +Y P S C +D+ +FPFD Q+C L F S+ Y S+ L M++ D
Sbjct: 159 VSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITD 218
Query: 97 ISGYI--PNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLI 154
S I +GEW+L+G+ ++ Y + F V +RRR Y +NLL+P +
Sbjct: 219 ASRNILQTHGEWELLGL--SKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFL 276
Query: 155 SALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIV 214
A+ L F LP SG ++ IT+LL VF+L++++++P + PLI YFA + ++
Sbjct: 277 VAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLP--TSGTPLIGVYFALCLSLM 334
Query: 215 GLSVVVTVIVLQ-YHHHDPDGGKMPKWTRVILLN 247
S++ T+ + H +P+W +LL+
Sbjct: 335 VGSLLETIFITHLLHVATTQPPPLPRWLHSLLLH 368
>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
[Homo sapiens]
Length = 441
Score = 95.5 bits (236), Expect = 8e-20
Identities = 59/203 (29%), Positives = 102/203 (50%), Gaps = 8/203 (3%)
Query: 40 VLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEA---- 95
V VNSSG + P S+C ++ FPFDVQ+C L F S + +DL +
Sbjct: 135 VYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDI 194
Query: 96 --DISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVL 153
D ++ + EW+L+ + S + + + F V MRR L Y ++LLIP +
Sbjct: 195 QHDKKAFLNDSEWELLSVSSTYS--ILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIF 252
Query: 154 ISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMII 213
+ + L F LP + +I +VL+ TVF + ++ +P + S PLI +F M
Sbjct: 253 LMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAF 312
Query: 214 VGLSVVVTVIVLQYHHHDPDGGK 236
+ LS+ +++++++ H + GG+
Sbjct: 313 LVLSLAKSIVLVKFLHDEQRGGQ 335
>gi|223468705 5-hydroxytryptamine receptor 3 subunit D isoform 1
[Homo sapiens]
Length = 404
Score = 57.4 bits (137), Expect = 2e-08
Identities = 56/206 (27%), Positives = 92/206 (44%), Gaps = 27/206 (13%)
Query: 105 EWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLY--YGLNLLIPCVLISALALLVF 162
EW L+GI KR+ + + Y F V +RRR Y +N L+P ++ A+ L F
Sbjct: 146 EWVLLGIQ-KRTIKVTVATNQ-YEQAIFHVAIRRRCRPSPYVVNFLVPSGILIAIDALSF 203
Query: 163 LLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDS--VPLI----------AQYFAST 210
LP +SG +TVLL +VF+L++ +++PATS S L+ YFA
Sbjct: 204 YLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGVYFALC 263
Query: 211 MIIVGLSVVVTVIVLQ-YHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQH 269
+ ++ S++ T+ + H +P+W +LL+ C G+ + P
Sbjct: 264 LSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLH-CT--------GQGRCCPTAPQ 314
Query: 270 K-QRRCSLASVEMSAVAPPPASNGNL 294
K + L + V P S G +
Sbjct: 315 KGNKGPGLTPTHLPGVKEPEVSAGQM 340
>gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1
precursor [Homo sapiens]
Length = 474
Score = 55.8 bits (133), Expect = 7e-08
Identities = 45/182 (24%), Positives = 83/182 (45%), Gaps = 28/182 (15%)
Query: 58 SSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVG------- 110
++C +D+R +P D Q+C L+ S+ Y DI Y GE + G
Sbjct: 159 AACMMDLRRYPLDEQNCTLEIESYGY---------TTDDIEFYWNGGEGAVTGVNKIELP 209
Query: 111 ----IPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPA 166
+ K + E YP ++ + ++R Y+ L +P LI+ L+ + F +
Sbjct: 210 QFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINY 269
Query: 167 D-SGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVL 225
D S +++LGIT +L++T + E +P +P + A + ++G V V + +L
Sbjct: 270 DASAARVALGITTVLTMTTISTHLRETLP----KIPYVK---AIDIYLMGCFVFVFLALL 322
Query: 226 QY 227
+Y
Sbjct: 323 EY 324
>gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precursor
[Homo sapiens]
Length = 465
Score = 54.7 bits (130), Expect = 2e-07
Identities = 42/192 (21%), Positives = 82/192 (42%), Gaps = 11/192 (5%)
Query: 15 LIQHLWIA----ANCDIADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFD 70
++ +WI N +D + T + + + + G Y + CY+ + FP D
Sbjct: 139 MVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMD 198
Query: 71 VQHCKLKFGSWSYGGWSLDLQMQEADISGYIPN----GEWDLVGIPGKRSERFYECCKEP 126
C L+F S+ Y ++ + ++ + P ++ VG+ + S
Sbjct: 199 EHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGL--RNSTEITHTISGD 256
Query: 127 YPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADS-GEKISLGITVLLSLTVF 185
Y +T + RR Y+ + IPC+L L+ + F + D+ + SLGIT +L++T
Sbjct: 257 YVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTL 316
Query: 186 MLLVAEIMPATS 197
+ + +P S
Sbjct: 317 STIARKSLPKVS 328
>gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3
isoform 2 precursor [Homo sapiens]
Length = 473
Score = 54.7 bits (130), Expect = 2e-07
Identities = 44/182 (24%), Positives = 83/182 (45%), Gaps = 28/182 (15%)
Query: 58 SSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSE 117
++C +D+R +P D Q+C L+ S+ Y DI Y G+ + G+
Sbjct: 159 AACMMDLRRYPLDEQNCTLEIESYGY---------TTDDIEFYWRGGDKAVTGVERIELP 209
Query: 118 RF-----------YECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPA 166
+F YP ++ + ++R Y+ L +P +LI+ L+ + F +
Sbjct: 210 QFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINY 269
Query: 167 D-SGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVL 225
D S +++LGIT +L++T + E +P +P + A M ++G V V + +L
Sbjct: 270 DASAARVALGITTVLTMTTINTHLRETLP----KIPYVK---AIDMYLMGCFVFVFLALL 322
Query: 226 QY 227
+Y
Sbjct: 323 EY 324
>gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3
isoform 1 precursor [Homo sapiens]
Length = 473
Score = 54.7 bits (130), Expect = 2e-07
Identities = 44/182 (24%), Positives = 83/182 (45%), Gaps = 28/182 (15%)
Query: 58 SSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSE 117
++C +D+R +P D Q+C L+ S+ Y DI Y G+ + G+
Sbjct: 159 AACMMDLRRYPLDEQNCTLEIESYGY---------TTDDIEFYWRGGDKAVTGVERIELP 209
Query: 118 RF-----------YECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPA 166
+F YP ++ + ++R Y+ L +P +LI+ L+ + F +
Sbjct: 210 QFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINY 269
Query: 167 D-SGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVL 225
D S +++LGIT +L++T + E +P +P + A M ++G V V + +L
Sbjct: 270 DASAARVALGITTVLTMTTINTHLRETLP----KIPYVK---AIDMYLMGCFVFVFLALL 322
Query: 226 QY 227
+Y
Sbjct: 323 EY 324
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.326 0.141 0.462
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,430,081
Number of Sequences: 37866
Number of extensions: 832769
Number of successful extensions: 2261
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 56
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 2116
Number of HSP's gapped (non-prelim): 111
length of query: 412
length of database: 18,247,518
effective HSP length: 105
effective length of query: 307
effective length of database: 14,271,588
effective search space: 4381377516
effective search space used: 4381377516
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.