Search of human proteins with 23238188

Search of human proteins with 23238188

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|23238188 testin isoform 2 [Homo sapiens]
         (412 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7661666 testin isoform 1 [Homo sapiens]                            891   0.0  
gi|23238188 testin isoform 2 [Homo sapiens]                           891   0.0  
gi|7657309 LIM and cysteine-rich domains 1 [Homo sapiens]             378   e-105
gi|7710129 LIM domain only 6 [Homo sapiens]                           288   5e-78
gi|38524620 prickle-like 2 [Homo sapiens]                             255   4e-68
gi|222136684 prickle homolog 1 [Homo sapiens]                         252   5e-67
gi|222136682 prickle homolog 1 [Homo sapiens]                         252   5e-67
gi|222136680 prickle homolog 1 [Homo sapiens]                         252   5e-67
gi|222136678 prickle homolog 1 [Homo sapiens]                         252   5e-67
gi|118722347 over-expressed breast tumor protein [Homo sapiens]       142   7e-34
gi|87159836 four and a half LIM domains 2 [Homo sapiens]              100   2e-21
gi|87159834 four and a half LIM domains 2 [Homo sapiens]              100   2e-21
gi|42403575 four and a half LIM domains 2 [Homo sapiens]              100   2e-21
gi|87159832 four and a half LIM domains 2 [Homo sapiens]              100   2e-21
gi|228480213 four and a half LIM domains 1 isoform 2 [Homo sapiens]    94   3e-19
gi|228480211 four and a half LIM domains 1 isoform 1 [Homo sapiens]    94   3e-19
gi|228480207 four and a half LIM domains 1 isoform 2 [Homo sapiens]    94   3e-19
gi|228480209 four and a half LIM domains 1 isoform 3 [Homo sapiens]    94   3e-19
gi|228480205 four and a half LIM domains 1 isoform 5 [Homo sapiens]    94   3e-19
gi|21361122 four and a half LIM domains 1 isoform 2 [Homo sapiens]     94   3e-19
gi|170932518 paxillin isoform 3 [Homo sapiens]                         86   6e-17
gi|170932516 paxillin isoform 2 [Homo sapiens]                         86   6e-17
gi|170932514 paxillin isoform 1 [Homo sapiens]                         86   6e-17
gi|221316659 leupaxin isoform 1 [Homo sapiens]                         86   6e-17
gi|4758670 leupaxin isoform 2 [Homo sapiens]                           86   6e-17
gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens]             84   2e-16
gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]              84   2e-16
gi|54112385 four and a half LIM domains 3 [Homo sapiens]               84   2e-16
gi|30410801 activator of cAMP-responsive element modulator (CREM...    84   2e-16
gi|109638745 transforming growth factor beta 1 induced transcrip...    82   1e-15

>gi|7661666 testin isoform 1 [Homo sapiens]
          Length = 421

 Score =  891 bits (2303), Expect = 0.0
 Identities = 412/412 (100%), Positives = 412/412 (100%)

Query: 1   MGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEEDRKVGKLFED 60
           MGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEEDRKVGKLFED
Sbjct: 10  MGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEEDRKVGKLFED 69

Query: 61  TKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQM 120
           TKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQM
Sbjct: 70  TKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQM 129

Query: 121 LPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEALGV 180
           LPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEALGV
Sbjct: 130 LPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEALGV 189

Query: 181 GDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPA 240
           GDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPA
Sbjct: 190 GDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPA 249

Query: 241 IYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIF 300
           IYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIF
Sbjct: 250 IYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIF 309

Query: 301 SNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAID 360
           SNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAID
Sbjct: 310 SNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAID 369

Query: 361 PEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKRMS 412
           PEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKRMS
Sbjct: 370 PEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKRMS 421


>gi|23238188 testin isoform 2 [Homo sapiens]
          Length = 412

 Score =  891 bits (2303), Expect = 0.0
 Identities = 412/412 (100%), Positives = 412/412 (100%)

Query: 1   MGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEEDRKVGKLFED 60
           MGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEEDRKVGKLFED
Sbjct: 1   MGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEEDRKVGKLFED 60

Query: 61  TKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQM 120
           TKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQM
Sbjct: 61  TKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQM 120

Query: 121 LPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEALGV 180
           LPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEALGV
Sbjct: 121 LPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEALGV 180

Query: 181 GDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPA 240
           GDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPA
Sbjct: 181 GDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPA 240

Query: 241 IYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIF 300
           IYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIF
Sbjct: 241 IYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIF 300

Query: 301 SNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAID 360
           SNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAID
Sbjct: 301 SNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAID 360

Query: 361 PEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKRMS 412
           PEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKRMS
Sbjct: 361 PEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKRMS 412


>gi|7657309 LIM and cysteine-rich domains 1 [Homo sapiens]
          Length = 365

 Score =  378 bits (971), Expect = e-105
 Identities = 177/348 (50%), Positives = 238/348 (68%), Gaps = 8/348 (2%)

Query: 1   MGLGHEQGF-GAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEEDRKVGKLFE 59
           M LG  Q   G  CL CK  C GFE H WRKIC++CKC QE+H +    E+DRK+G+L  
Sbjct: 15  MSLGQLQSARGVACLGCKGTCSGFEPHSWRKICKSCKCSQEDHCLTSDLEDDRKIGRLLM 74

Query: 60  DTKYTTLIAKLKS-DGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYM 118
           D+KY+TL A++K  DGI +YKRN MI+TNP+A  K+ + +T+TYEWAPP   Q L  QYM
Sbjct: 75  DSKYSTLTARVKGGDGIRIYKRNRMIMTNPIATGKDPTFDTITYEWAPPGVTQKLGLQYM 134

Query: 119 QMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEAL 178
           +++PKEKQPV G+EGA YR++QL  QLP +DQDPS+C  L   E+K ME+FVK+YKSEAL
Sbjct: 135 ELIPKEKQPVTGTEGAFYRRRQLMHQLPIYDQDPSRCRGLLENELKLMEEFVKQYKSEAL 194

Query: 179 GVGDVKLPCE--MDAQGPKQMNIPGGDRSTPAAV-GAMEDKSAEHKRTQYSCYCCKLSMK 235
           GVG+V LP +  +  +  KQ   P G  +T A   G++ D S   K  +Y C  CK +  
Sbjct: 195 GVGEVALPGQGGLPKEEGKQQEKPEGAETTAATTNGSLSDPS---KEVEYVCELCKGAAP 251

Query: 236 EGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGC 295
              P +Y++RAGY+K WHP CFVC+ C E LVD+IYFWK+   +CGRHYC+S +PRC+GC
Sbjct: 252 PDSPVVYSDRAGYNKQWHPTCFVCAKCSEPLVDLIYFWKDGAPWCGRHYCESLRPRCSGC 311

Query: 296 DELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPC 343
           DE+IF+ +Y + E+  WH KHF C  C+ +L+G  Y++   + +C  C
Sbjct: 312 DEIIFAEDYQRVEDLAWHRKHFVCEGCEQLLSGRAYIVTKGQLLCPTC 359


>gi|7710129 LIM domain only 6 [Homo sapiens]
          Length = 615

 Score =  288 bits (738), Expect = 5e-78
 Identities = 149/398 (37%), Positives = 205/398 (51%), Gaps = 55/398 (13%)

Query: 10  GAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEEDRKVGKLFEDTKYTTLIAK 69
           G PC  C+E+C GF LH WRKIC++CKC +EEH V     +  ++            + +
Sbjct: 24  GQPCNSCREQCPGFLLHGWRKICQHCKCPREEHAVHAVPVDLERI------------MCR 71

Query: 70  LKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQMLPKEKQPVA 129
           L SD    ++R+ +   +   A +        Y W PP        Q+   LP++K P  
Sbjct: 72  LISD----FQRHSISDDDSGCASEE-------YAWVPPGLKPEQVYQFFSCLPEDKVPYV 120

Query: 130 GSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEALGVGDVKLPCEM 189
            S G +YR KQL  QLP HD +   C  L   E KE+  F ++ K E LG G V++    
Sbjct: 121 NSPGEKYRIKQLLHQLPPHDSEAQYCTALEEEEKKELRAFSQQRKRENLGRGIVRI---- 176

Query: 190 DAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAIYAERAGYD 249
                            P  +            T   C  C   +  GD A++A RAG  
Sbjct: 177 ----------------FPVTI------------TGAICEECGKQIGGGDIAVFASRAGLG 208

Query: 250 KLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAEN 309
             WHP CFVC+TC ELLVD+IYF+   K+YCGRH+ +  +PRC  CDE+IFS E T+AE 
Sbjct: 209 ACWHPQCFVCTTCQELLVDLIYFYHVGKVYCGRHHAECLRPRCQACDEIIFSPECTEAEG 268

Query: 310 QNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYN 369
           ++WH+ HFCCF+C++ L G+ YVM   +P C  CY   HA  C GC   I  +  ++ Y 
Sbjct: 269 RHWHMDHFCCFECEASLGGQRYVMRQSRPHCCACYEARHAEYCDGCGEHIGLDQGQMAYE 328

Query: 370 NFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVEC 407
              WHAS  CF CS C + L+G+ F+P  G++FCS  C
Sbjct: 329 GQHWHASDRCFCCSRCGRALLGRPFLPRRGLIFCSRAC 366


>gi|38524620 prickle-like 2 [Homo sapiens]
          Length = 844

 Score =  255 bits (652), Expect = 4e-68
 Identities = 119/306 (38%), Positives = 171/306 (55%), Gaps = 32/306 (10%)

Query: 102 YEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPR 161
           Y W PP        QY   LP+EK P   S G + R KQL  QLP HD +   C+ L   
Sbjct: 37  YAWVPPGLKPEQVHQYYSCLPEEKVPYVNSPGEKLRIKQLLHQLPPHDNEVRYCNSLDEE 96

Query: 162 EVKEMEQFVKKYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHK 221
           E +E++ F  + K E LG G+V+         P  + + G                    
Sbjct: 97  EKRELKLFSSQRKRENLGRGNVR---------PFPVTMTGA------------------- 128

Query: 222 RTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCG 281
                C  C   +  GD A++A RAG+   WHP CFVC+ C+ELLVD+IYF+++ K+YCG
Sbjct: 129 ----ICEQCGGQINGGDIAVFASRAGHGVCWHPPCFVCTVCNELLVDLIYFYQDGKIYCG 184

Query: 282 RHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCK 341
           RH+ +  KPRCA CDE+IF++E T+AE ++WH+KHFCCF+C+++L G+ Y+M   +P C 
Sbjct: 185 RHHAECLKPRCAACDEIIFADECTEAEGRHWHMKHFCCFECETVLGGQRYIMKEGRPYCC 244

Query: 342 PCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMV 401
            C+   +A  C  C   I  +  ++TY+   WHA+  CF C+ C K L+G+ F+P +G +
Sbjct: 245 HCFESLYAEYCDTCAQHIGIDQGQMTYDGQHWHATETCFCCAHCKKSLLGRPFLPKQGQI 304

Query: 402 FCSVEC 407
           FCS  C
Sbjct: 305 FCSRAC 310



 Score = 31.6 bits (70), Expect = 1.4
 Identities = 30/125 (24%), Positives = 46/125 (36%), Gaps = 34/125 (27%)

Query: 212 AMEDKSAEHKRTQYSCYCC----------KLSMKEGDP-------AIYAE---------- 244
           A E   AE +      +CC          +  MKEG P       ++YAE          
Sbjct: 204 ADECTEAEGRHWHMKHFCCFECETVLGGQRYIMKEGRPYCCHCFESLYAEYCDTCAQHIG 263

Query: 245 ----RAGYD-KLWHPA--CFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDE 297
               +  YD + WH    CF C+ C + L+   +  K  +++C R     E P  +   +
Sbjct: 264 IDQGQMTYDGQHWHATETCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDPNGSDSSD 323

Query: 298 LIFSN 302
             F N
Sbjct: 324 SAFQN 328


>gi|222136684 prickle homolog 1 [Homo sapiens]
          Length = 831

 Score =  252 bits (643), Expect = 5e-67
 Identities = 119/306 (38%), Positives = 173/306 (56%), Gaps = 32/306 (10%)

Query: 102 YEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPR 161
           Y W PP       + Y   LP+EK P   S G ++R KQL  QLP HD +   C  LS  
Sbjct: 33  YAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQSLSEE 92

Query: 162 EVKEMEQFVKKYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHK 221
           E KE++ F  + K EALG G +KL                  R+   AV           
Sbjct: 93  EKKELQVFSAQRKKEALGRGTIKLL----------------SRAVMHAV----------- 125

Query: 222 RTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCG 281
                C  C L +  G+ A++A RAG    WHP+CFVC TC+ELLVD+IYF+++ K++CG
Sbjct: 126 -----CEQCGLKINGGEVAVFASRAGPGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCG 180

Query: 282 RHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCK 341
           RH+ +  KPRC+ CDE+IF++E T+AE ++WH+KHFCC +C+++L G+ Y+M + +P C 
Sbjct: 181 RHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCC 240

Query: 342 PCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMV 401
            C+   +A  C+ C   I  +  ++TY+   WHA+  CF C+ C   L+G  F+P +G +
Sbjct: 241 GCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKASLLGCPFLPKQGQI 300

Query: 402 FCSVEC 407
           +CS  C
Sbjct: 301 YCSKTC 306


>gi|222136682 prickle homolog 1 [Homo sapiens]
          Length = 831

 Score =  252 bits (643), Expect = 5e-67
 Identities = 119/306 (38%), Positives = 173/306 (56%), Gaps = 32/306 (10%)

Query: 102 YEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPR 161
           Y W PP       + Y   LP+EK P   S G ++R KQL  QLP HD +   C  LS  
Sbjct: 33  YAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQSLSEE 92

Query: 162 EVKEMEQFVKKYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHK 221
           E KE++ F  + K EALG G +KL                  R+   AV           
Sbjct: 93  EKKELQVFSAQRKKEALGRGTIKLL----------------SRAVMHAV----------- 125

Query: 222 RTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCG 281
                C  C L +  G+ A++A RAG    WHP+CFVC TC+ELLVD+IYF+++ K++CG
Sbjct: 126 -----CEQCGLKINGGEVAVFASRAGPGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCG 180

Query: 282 RHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCK 341
           RH+ +  KPRC+ CDE+IF++E T+AE ++WH+KHFCC +C+++L G+ Y+M + +P C 
Sbjct: 181 RHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCC 240

Query: 342 PCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMV 401
            C+   +A  C+ C   I  +  ++TY+   WHA+  CF C+ C   L+G  F+P +G +
Sbjct: 241 GCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKASLLGCPFLPKQGQI 300

Query: 402 FCSVEC 407
           +CS  C
Sbjct: 301 YCSKTC 306


>gi|222136680 prickle homolog 1 [Homo sapiens]
          Length = 831

 Score =  252 bits (643), Expect = 5e-67
 Identities = 119/306 (38%), Positives = 173/306 (56%), Gaps = 32/306 (10%)

Query: 102 YEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPR 161
           Y W PP       + Y   LP+EK P   S G ++R KQL  QLP HD +   C  LS  
Sbjct: 33  YAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQSLSEE 92

Query: 162 EVKEMEQFVKKYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHK 221
           E KE++ F  + K EALG G +KL                  R+   AV           
Sbjct: 93  EKKELQVFSAQRKKEALGRGTIKLL----------------SRAVMHAV----------- 125

Query: 222 RTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCG 281
                C  C L +  G+ A++A RAG    WHP+CFVC TC+ELLVD+IYF+++ K++CG
Sbjct: 126 -----CEQCGLKINGGEVAVFASRAGPGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCG 180

Query: 282 RHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCK 341
           RH+ +  KPRC+ CDE+IF++E T+AE ++WH+KHFCC +C+++L G+ Y+M + +P C 
Sbjct: 181 RHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCC 240

Query: 342 PCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMV 401
            C+   +A  C+ C   I  +  ++TY+   WHA+  CF C+ C   L+G  F+P +G +
Sbjct: 241 GCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKASLLGCPFLPKQGQI 300

Query: 402 FCSVEC 407
           +CS  C
Sbjct: 301 YCSKTC 306


>gi|222136678 prickle homolog 1 [Homo sapiens]
          Length = 831

 Score =  252 bits (643), Expect = 5e-67
 Identities = 119/306 (38%), Positives = 173/306 (56%), Gaps = 32/306 (10%)

Query: 102 YEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPR 161
           Y W PP       + Y   LP+EK P   S G ++R KQL  QLP HD +   C  LS  
Sbjct: 33  YAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQSLSEE 92

Query: 162 EVKEMEQFVKKYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHK 221
           E KE++ F  + K EALG G +KL                  R+   AV           
Sbjct: 93  EKKELQVFSAQRKKEALGRGTIKLL----------------SRAVMHAV----------- 125

Query: 222 RTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCG 281
                C  C L +  G+ A++A RAG    WHP+CFVC TC+ELLVD+IYF+++ K++CG
Sbjct: 126 -----CEQCGLKINGGEVAVFASRAGPGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCG 180

Query: 282 RHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCK 341
           RH+ +  KPRC+ CDE+IF++E T+AE ++WH+KHFCC +C+++L G+ Y+M + +P C 
Sbjct: 181 RHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCC 240

Query: 342 PCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMV 401
            C+   +A  C+ C   I  +  ++TY+   WHA+  CF C+ C   L+G  F+P +G +
Sbjct: 241 GCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKASLLGCPFLPKQGQI 300

Query: 402 FCSVEC 407
           +CS  C
Sbjct: 301 YCSKTC 306


>gi|118722347 over-expressed breast tumor protein [Homo sapiens]
          Length = 384

 Score =  142 bits (357), Expect = 7e-34
 Identities = 71/209 (33%), Positives = 102/209 (48%), Gaps = 32/209 (15%)

Query: 141 LAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEALGVGDVKLPCEMDAQGPKQMNIP 200
           L +QLP  D D   C  L   E  E++ F  + K EALG            QG  ++ +P
Sbjct: 70  LLQQLPPQDIDERYCLALGEEERAELQLFCARRKQEALG------------QGVARLVLP 117

Query: 201 GGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCS 260
                               K   ++C  C+  +K G+  ++A RAG  + WH  CF C 
Sbjct: 118 --------------------KLEGHTCEKCRELLKPGEYGVFAARAGEQRCWHQPCFACQ 157

Query: 261 TCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCF 320
            C + L+++IYF+ + +LYCGRH+ +  +PRC  CD+LIFS   T+AE Q WH  HFCC 
Sbjct: 158 ACGQALINLIYFYHDGQLYCGRHHAELLRPRCPACDQLIFSWRCTEAEGQRWHENHFCCQ 217

Query: 321 DCDSILAGEIYVMVNDKPVCKPCYVKNHA 349
           DC   L G  Y +    P C  C+   ++
Sbjct: 218 DCAGPLGGGRYALPGGSPCCPSCFENRYS 246


>gi|87159836 four and a half LIM domains 2 [Homo sapiens]
          Length = 279

 Score =  100 bits (249), Expect = 2e-21
 Identities = 50/156 (32%), Positives = 73/156 (46%), Gaps = 5/156 (3%)

Query: 249 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIF-SNEYTQA 307
           D+ WH ACF CS C   LVD  +  K ++L C   Y +    +C  C + I       + 
Sbjct: 58  DRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEY 117

Query: 308 ENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVT 367
           +  +WH   F C  C   +  + ++  +++  C PCY K HA+ C  C   I      VT
Sbjct: 118 KGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPI--TTGGVT 175

Query: 368 YNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFC 403
           Y    WH   ECF+C+ C K L GQ+F   +   +C
Sbjct: 176 YREQPWH--KECFVCTACRKQLSGQRFTARDDFAYC 209



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 50/190 (26%), Positives = 83/190 (43%), Gaps = 12/190 (6%)

Query: 224 QYSCYC--CKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCG 281
           +YS  C  CK ++  G   +  + +     WH  CF+C  C + +    +  K+ + +C 
Sbjct: 96  EYSSKCQECKKTIMPGTRKMEYKGSS----WHETCFICHRCQQPIGTKSFIPKDNQNFCV 151

Query: 282 RHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCK 341
             Y      +C  C + I +   T  E Q WH + F C  C   L+G+ +   +D   C 
Sbjct: 152 PCYEKQHAMQCVQCKKPITTGGVTYRE-QPWHKECFVCTACRKQLSGQRFTARDDFAYCL 210

Query: 342 PCYVKNHAVVCQGCHNAID--PEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEG 399
            C+   +A  C GC N I      + +++    WH   +CF C  CS  L+G+ F+    
Sbjct: 211 NCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWH--NDCFNCKKCSLSLVGRGFLTERD 268

Query: 400 MVFCSVECKK 409
            + C  +C K
Sbjct: 269 DILCP-DCGK 277



 Score = 75.5 bits (184), Expect = 8e-14
 Identities = 41/159 (25%), Positives = 69/159 (43%), Gaps = 26/159 (16%)

Query: 275 NEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQA-------------ENQNWHLKHFCCFD 321
           NE L+  ++    E P C  C E +F+N   +              ++++WH   F C  
Sbjct: 11  NESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWHEACFHCSQ 70

Query: 322 CDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFL 381
           C + L  + +    D+ +C  CY   ++  CQ C   I P  +++ Y   SWH +  CF+
Sbjct: 71  CRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHET--CFI 128

Query: 382 CSCCSKCLIGQKFMPVEGMVFC-----------SVECKK 409
           C  C + +  + F+P +   FC            V+CKK
Sbjct: 129 CHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKK 167



 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 36/126 (28%), Positives = 52/126 (41%), Gaps = 9/126 (7%)

Query: 221 KRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYC 280
           K+    C  CK  +  G    Y E+      WH  CFVC+ C + L    +  +++  YC
Sbjct: 156 KQHAMQCVQCKKPITTGG-VTYREQP-----WHKECFVCTACRKQLSGQRFTARDDFAYC 209

Query: 281 GRHYCDSEKPRCAGCDELIF---SNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDK 337
              +CD    +CAGC   I      +Y   E + WH   F C  C   L G  ++   D 
Sbjct: 210 LNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD 269

Query: 338 PVCKPC 343
            +C  C
Sbjct: 270 ILCPDC 275



 Score = 55.5 bits (132), Expect = 9e-08
 Identities = 25/90 (27%), Positives = 43/90 (47%), Gaps = 2/90 (2%)

Query: 315 KHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWH 374
           + F C  C+  L G+ Y++  + P C  C+    A  C+ C   I  + + ++Y +  WH
Sbjct: 3   ERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWH 62

Query: 375 ASTECFLCSCCSKCLIGQKFMPVEGMVFCS 404
            +  CF CS C   L+ + F   E  + C+
Sbjct: 63  EA--CFHCSQCRNSLVDKPFAAKEDQLLCT 90


>gi|87159834 four and a half LIM domains 2 [Homo sapiens]
          Length = 279

 Score =  100 bits (249), Expect = 2e-21
 Identities = 50/156 (32%), Positives = 73/156 (46%), Gaps = 5/156 (3%)

Query: 249 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIF-SNEYTQA 307
           D+ WH ACF CS C   LVD  +  K ++L C   Y +    +C  C + I       + 
Sbjct: 58  DRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEY 117

Query: 308 ENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVT 367
           +  +WH   F C  C   +  + ++  +++  C PCY K HA+ C  C   I      VT
Sbjct: 118 KGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPI--TTGGVT 175

Query: 368 YNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFC 403
           Y    WH   ECF+C+ C K L GQ+F   +   +C
Sbjct: 176 YREQPWH--KECFVCTACRKQLSGQRFTARDDFAYC 209



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 50/190 (26%), Positives = 83/190 (43%), Gaps = 12/190 (6%)

Query: 224 QYSCYC--CKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCG 281
           +YS  C  CK ++  G   +  + +     WH  CF+C  C + +    +  K+ + +C 
Sbjct: 96  EYSSKCQECKKTIMPGTRKMEYKGSS----WHETCFICHRCQQPIGTKSFIPKDNQNFCV 151

Query: 282 RHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCK 341
             Y      +C  C + I +   T  E Q WH + F C  C   L+G+ +   +D   C 
Sbjct: 152 PCYEKQHAMQCVQCKKPITTGGVTYRE-QPWHKECFVCTACRKQLSGQRFTARDDFAYCL 210

Query: 342 PCYVKNHAVVCQGCHNAID--PEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEG 399
            C+   +A  C GC N I      + +++    WH   +CF C  CS  L+G+ F+    
Sbjct: 211 NCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWH--NDCFNCKKCSLSLVGRGFLTERD 268

Query: 400 MVFCSVECKK 409
            + C  +C K
Sbjct: 269 DILCP-DCGK 277



 Score = 75.5 bits (184), Expect = 8e-14
 Identities = 41/159 (25%), Positives = 69/159 (43%), Gaps = 26/159 (16%)

Query: 275 NEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQA-------------ENQNWHLKHFCCFD 321
           NE L+  ++    E P C  C E +F+N   +              ++++WH   F C  
Sbjct: 11  NESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWHEACFHCSQ 70

Query: 322 CDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFL 381
           C + L  + +    D+ +C  CY   ++  CQ C   I P  +++ Y   SWH +  CF+
Sbjct: 71  CRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHET--CFI 128

Query: 382 CSCCSKCLIGQKFMPVEGMVFC-----------SVECKK 409
           C  C + +  + F+P +   FC            V+CKK
Sbjct: 129 CHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKK 167



 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 36/126 (28%), Positives = 52/126 (41%), Gaps = 9/126 (7%)

Query: 221 KRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYC 280
           K+    C  CK  +  G    Y E+      WH  CFVC+ C + L    +  +++  YC
Sbjct: 156 KQHAMQCVQCKKPITTGG-VTYREQP-----WHKECFVCTACRKQLSGQRFTARDDFAYC 209

Query: 281 GRHYCDSEKPRCAGCDELIF---SNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDK 337
              +CD    +CAGC   I      +Y   E + WH   F C  C   L G  ++   D 
Sbjct: 210 LNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD 269

Query: 338 PVCKPC 343
            +C  C
Sbjct: 270 ILCPDC 275



 Score = 55.5 bits (132), Expect = 9e-08
 Identities = 25/90 (27%), Positives = 43/90 (47%), Gaps = 2/90 (2%)

Query: 315 KHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWH 374
           + F C  C+  L G+ Y++  + P C  C+    A  C+ C   I  + + ++Y +  WH
Sbjct: 3   ERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWH 62

Query: 375 ASTECFLCSCCSKCLIGQKFMPVEGMVFCS 404
            +  CF CS C   L+ + F   E  + C+
Sbjct: 63  EA--CFHCSQCRNSLVDKPFAAKEDQLLCT 90


>gi|42403575 four and a half LIM domains 2 [Homo sapiens]
          Length = 279

 Score =  100 bits (249), Expect = 2e-21
 Identities = 50/156 (32%), Positives = 73/156 (46%), Gaps = 5/156 (3%)

Query: 249 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIF-SNEYTQA 307
           D+ WH ACF CS C   LVD  +  K ++L C   Y +    +C  C + I       + 
Sbjct: 58  DRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEY 117

Query: 308 ENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVT 367
           +  +WH   F C  C   +  + ++  +++  C PCY K HA+ C  C   I      VT
Sbjct: 118 KGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPI--TTGGVT 175

Query: 368 YNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFC 403
           Y    WH   ECF+C+ C K L GQ+F   +   +C
Sbjct: 176 YREQPWH--KECFVCTACRKQLSGQRFTARDDFAYC 209



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 50/190 (26%), Positives = 83/190 (43%), Gaps = 12/190 (6%)

Query: 224 QYSCYC--CKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCG 281
           +YS  C  CK ++  G   +  + +     WH  CF+C  C + +    +  K+ + +C 
Sbjct: 96  EYSSKCQECKKTIMPGTRKMEYKGSS----WHETCFICHRCQQPIGTKSFIPKDNQNFCV 151

Query: 282 RHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCK 341
             Y      +C  C + I +   T  E Q WH + F C  C   L+G+ +   +D   C 
Sbjct: 152 PCYEKQHAMQCVQCKKPITTGGVTYRE-QPWHKECFVCTACRKQLSGQRFTARDDFAYCL 210

Query: 342 PCYVKNHAVVCQGCHNAID--PEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEG 399
            C+   +A  C GC N I      + +++    WH   +CF C  CS  L+G+ F+    
Sbjct: 211 NCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWH--NDCFNCKKCSLSLVGRGFLTERD 268

Query: 400 MVFCSVECKK 409
            + C  +C K
Sbjct: 269 DILCP-DCGK 277



 Score = 75.5 bits (184), Expect = 8e-14
 Identities = 41/159 (25%), Positives = 69/159 (43%), Gaps = 26/159 (16%)

Query: 275 NEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQA-------------ENQNWHLKHFCCFD 321
           NE L+  ++    E P C  C E +F+N   +              ++++WH   F C  
Sbjct: 11  NESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWHEACFHCSQ 70

Query: 322 CDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFL 381
           C + L  + +    D+ +C  CY   ++  CQ C   I P  +++ Y   SWH +  CF+
Sbjct: 71  CRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHET--CFI 128

Query: 382 CSCCSKCLIGQKFMPVEGMVFC-----------SVECKK 409
           C  C + +  + F+P +   FC            V+CKK
Sbjct: 129 CHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKK 167



 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 36/126 (28%), Positives = 52/126 (41%), Gaps = 9/126 (7%)

Query: 221 KRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYC 280
           K+    C  CK  +  G    Y E+      WH  CFVC+ C + L    +  +++  YC
Sbjct: 156 KQHAMQCVQCKKPITTGG-VTYREQP-----WHKECFVCTACRKQLSGQRFTARDDFAYC 209

Query: 281 GRHYCDSEKPRCAGCDELIF---SNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDK 337
              +CD    +CAGC   I      +Y   E + WH   F C  C   L G  ++   D 
Sbjct: 210 LNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD 269

Query: 338 PVCKPC 343
            +C  C
Sbjct: 270 ILCPDC 275



 Score = 55.5 bits (132), Expect = 9e-08
 Identities = 25/90 (27%), Positives = 43/90 (47%), Gaps = 2/90 (2%)

Query: 315 KHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWH 374
           + F C  C+  L G+ Y++  + P C  C+    A  C+ C   I  + + ++Y +  WH
Sbjct: 3   ERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWH 62

Query: 375 ASTECFLCSCCSKCLIGQKFMPVEGMVFCS 404
            +  CF CS C   L+ + F   E  + C+
Sbjct: 63  EA--CFHCSQCRNSLVDKPFAAKEDQLLCT 90


>gi|87159832 four and a half LIM domains 2 [Homo sapiens]
          Length = 279

 Score =  100 bits (249), Expect = 2e-21
 Identities = 50/156 (32%), Positives = 73/156 (46%), Gaps = 5/156 (3%)

Query: 249 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIF-SNEYTQA 307
           D+ WH ACF CS C   LVD  +  K ++L C   Y +    +C  C + I       + 
Sbjct: 58  DRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEY 117

Query: 308 ENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVT 367
           +  +WH   F C  C   +  + ++  +++  C PCY K HA+ C  C   I      VT
Sbjct: 118 KGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPI--TTGGVT 175

Query: 368 YNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFC 403
           Y    WH   ECF+C+ C K L GQ+F   +   +C
Sbjct: 176 YREQPWH--KECFVCTACRKQLSGQRFTARDDFAYC 209



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 50/190 (26%), Positives = 83/190 (43%), Gaps = 12/190 (6%)

Query: 224 QYSCYC--CKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCG 281
           +YS  C  CK ++  G   +  + +     WH  CF+C  C + +    +  K+ + +C 
Sbjct: 96  EYSSKCQECKKTIMPGTRKMEYKGSS----WHETCFICHRCQQPIGTKSFIPKDNQNFCV 151

Query: 282 RHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCK 341
             Y      +C  C + I +   T  E Q WH + F C  C   L+G+ +   +D   C 
Sbjct: 152 PCYEKQHAMQCVQCKKPITTGGVTYRE-QPWHKECFVCTACRKQLSGQRFTARDDFAYCL 210

Query: 342 PCYVKNHAVVCQGCHNAID--PEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEG 399
            C+   +A  C GC N I      + +++    WH   +CF C  CS  L+G+ F+    
Sbjct: 211 NCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWH--NDCFNCKKCSLSLVGRGFLTERD 268

Query: 400 MVFCSVECKK 409
            + C  +C K
Sbjct: 269 DILCP-DCGK 277



 Score = 75.5 bits (184), Expect = 8e-14
 Identities = 41/159 (25%), Positives = 69/159 (43%), Gaps = 26/159 (16%)

Query: 275 NEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQA-------------ENQNWHLKHFCCFD 321
           NE L+  ++    E P C  C E +F+N   +              ++++WH   F C  
Sbjct: 11  NESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWHEACFHCSQ 70

Query: 322 CDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFL 381
           C + L  + +    D+ +C  CY   ++  CQ C   I P  +++ Y   SWH +  CF+
Sbjct: 71  CRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHET--CFI 128

Query: 382 CSCCSKCLIGQKFMPVEGMVFC-----------SVECKK 409
           C  C + +  + F+P +   FC            V+CKK
Sbjct: 129 CHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKK 167



 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 36/126 (28%), Positives = 52/126 (41%), Gaps = 9/126 (7%)

Query: 221 KRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYC 280
           K+    C  CK  +  G    Y E+      WH  CFVC+ C + L    +  +++  YC
Sbjct: 156 KQHAMQCVQCKKPITTGG-VTYREQP-----WHKECFVCTACRKQLSGQRFTARDDFAYC 209

Query: 281 GRHYCDSEKPRCAGCDELIF---SNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDK 337
              +CD    +CAGC   I      +Y   E + WH   F C  C   L G  ++   D 
Sbjct: 210 LNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD 269

Query: 338 PVCKPC 343
            +C  C
Sbjct: 270 ILCPDC 275



 Score = 55.5 bits (132), Expect = 9e-08
 Identities = 25/90 (27%), Positives = 43/90 (47%), Gaps = 2/90 (2%)

Query: 315 KHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWH 374
           + F C  C+  L G+ Y++  + P C  C+    A  C+ C   I  + + ++Y +  WH
Sbjct: 3   ERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWH 62

Query: 375 ASTECFLCSCCSKCLIGQKFMPVEGMVFCS 404
            +  CF CS C   L+ + F   E  + C+
Sbjct: 63  EA--CFHCSQCRNSLVDKPFAAKEDQLLCT 90


>gi|228480213 four and a half LIM domains 1 isoform 2 [Homo sapiens]
          Length = 280

 Score = 93.6 bits (231), Expect = 3e-19
 Identities = 47/162 (29%), Positives = 77/162 (47%), Gaps = 6/162 (3%)

Query: 249 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGC-DELIFSNEYTQA 307
           ++ WH  CF C+ C   L +  +  K+ K+ C +     + P+C GC   ++  ++  + 
Sbjct: 58  NRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEY 117

Query: 308 ENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVT 367
           +   WH   F C +C  ++    +    +   C  C+    A  C  C+ AI      +T
Sbjct: 118 KGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITS--GGIT 175

Query: 368 YNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKK 409
           Y +  WHA  +CF+C  CSK L GQ+F  VE   +C V+C K
Sbjct: 176 YQDQPWHA--DCFVCVTCSKKLAGQRFTAVEDQYYC-VDCYK 214



 Score = 92.0 bits (227), Expect = 9e-19
 Identities = 53/164 (32%), Positives = 74/164 (45%), Gaps = 7/164 (4%)

Query: 251 LWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQ 310
           +WH  CF CS C +++    +F K E  YC   +       C  C++ I S   T  ++Q
Sbjct: 121 VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITY-QDQ 179

Query: 311 NWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAI---DPEVQRVT 367
            WH   F C  C   LAG+ +  V D+  C  CY    A  C GC N I         V 
Sbjct: 180 PWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVA 239

Query: 368 YNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKRM 411
           Y   SWH    CF C  CS  L  ++F+  +  V+C  +C K++
Sbjct: 240 YEGQSWH--DYCFHCKKCSVNLANKRFVFHQEQVYCP-DCAKKL 280



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 44/152 (28%), Positives = 65/152 (42%), Gaps = 4/152 (2%)

Query: 257 FVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSN-EYTQAENQNWHLK 315
           F C  C + L    Y  K+    C + +       C  C + I ++ +    +N+ WH  
Sbjct: 5   FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 64

Query: 316 HFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHA 375
            F C  C   LA E +V  ++K +C  C  +  +  C+GC  AI    Q V Y    WH 
Sbjct: 65  CFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVWH- 123

Query: 376 STECFLCSCCSKCLIGQKFMPVEGMVFCSVEC 407
             +CF CS C + +    F P +G  F  V C
Sbjct: 124 -KDCFTCSNCKQVIGTGSFFP-KGEDFYCVTC 153



 Score = 55.8 bits (133), Expect = 7e-08
 Identities = 31/102 (30%), Positives = 44/102 (43%), Gaps = 4/102 (3%)

Query: 249 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIF----SNEY 304
           D+ WH  CFVC TC + L    +    ++ YC   Y +    +CAGC   I      +  
Sbjct: 178 DQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSV 237

Query: 305 TQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVK 346
              E Q+WH   F C  C   LA + +V   ++  C  C  K
Sbjct: 238 VAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKK 279


>gi|228480211 four and a half LIM domains 1 isoform 1 [Homo sapiens]
          Length = 323

 Score = 93.6 bits (231), Expect = 3e-19
 Identities = 47/162 (29%), Positives = 77/162 (47%), Gaps = 6/162 (3%)

Query: 249 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGC-DELIFSNEYTQA 307
           ++ WH  CF C+ C   L +  +  K+ K+ C +     + P+C GC   ++  ++  + 
Sbjct: 58  NRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEY 117

Query: 308 ENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVT 367
           +   WH   F C +C  ++    +    +   C  C+    A  C  C+ AI      +T
Sbjct: 118 KGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITS--GGIT 175

Query: 368 YNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKK 409
           Y +  WHA  +CF+C  CSK L GQ+F  VE   +C V+C K
Sbjct: 176 YQDQPWHA--DCFVCVTCSKKLAGQRFTAVEDQYYC-VDCYK 214



 Score = 74.7 bits (182), Expect = 1e-13
 Identities = 40/120 (33%), Positives = 56/120 (46%), Gaps = 3/120 (2%)

Query: 251 LWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQ 310
           +WH  CF CS C +++    +F K E  YC   +       C  C++ I S   T  ++Q
Sbjct: 121 VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITY-QDQ 179

Query: 311 NWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPE--VQRVTY 368
            WH   F C  C   LAG+ +  V D+  C  CY    A  C GC N I  +  V RV++
Sbjct: 180 PWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGKRTVSRVSH 239



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 44/152 (28%), Positives = 65/152 (42%), Gaps = 4/152 (2%)

Query: 257 FVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSN-EYTQAENQNWHLK 315
           F C  C + L    Y  K+    C + +       C  C + I ++ +    +N+ WH  
Sbjct: 5   FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 64

Query: 316 HFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHA 375
            F C  C   LA E +V  ++K +C  C  +  +  C+GC  AI    Q V Y    WH 
Sbjct: 65  CFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVWH- 123

Query: 376 STECFLCSCCSKCLIGQKFMPVEGMVFCSVEC 407
             +CF CS C + +    F P +G  F  V C
Sbjct: 124 -KDCFTCSNCKQVIGTGSFFP-KGEDFYCVTC 153



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 17/47 (36%), Positives = 24/47 (51%)

Query: 249 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGC 295
           D+ WH  CFVC TC + L    +    ++ YC   Y +    +CAGC
Sbjct: 178 DQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGC 224


>gi|228480207 four and a half LIM domains 1 isoform 2 [Homo sapiens]
          Length = 280

 Score = 93.6 bits (231), Expect = 3e-19
 Identities = 47/162 (29%), Positives = 77/162 (47%), Gaps = 6/162 (3%)

Query: 249 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGC-DELIFSNEYTQA 307
           ++ WH  CF C+ C   L +  +  K+ K+ C +     + P+C GC   ++  ++  + 
Sbjct: 58  NRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEY 117

Query: 308 ENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVT 367
           +   WH   F C +C  ++    +    +   C  C+    A  C  C+ AI      +T
Sbjct: 118 KGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITS--GGIT 175

Query: 368 YNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKK 409
           Y +  WHA  +CF+C  CSK L GQ+F  VE   +C V+C K
Sbjct: 176 YQDQPWHA--DCFVCVTCSKKLAGQRFTAVEDQYYC-VDCYK 214



 Score = 92.0 bits (227), Expect = 9e-19
 Identities = 53/164 (32%), Positives = 74/164 (45%), Gaps = 7/164 (4%)

Query: 251 LWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQ 310
           +WH  CF CS C +++    +F K E  YC   +       C  C++ I S   T  ++Q
Sbjct: 121 VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITY-QDQ 179

Query: 311 NWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAI---DPEVQRVT 367
            WH   F C  C   LAG+ +  V D+  C  CY    A  C GC N I         V 
Sbjct: 180 PWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVA 239

Query: 368 YNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKRM 411
           Y   SWH    CF C  CS  L  ++F+  +  V+C  +C K++
Sbjct: 240 YEGQSWH--DYCFHCKKCSVNLANKRFVFHQEQVYCP-DCAKKL 280



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 44/152 (28%), Positives = 65/152 (42%), Gaps = 4/152 (2%)

Query: 257 FVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSN-EYTQAENQNWHLK 315
           F C  C + L    Y  K+    C + +       C  C + I ++ +    +N+ WH  
Sbjct: 5   FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 64

Query: 316 HFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHA 375
            F C  C   LA E +V  ++K +C  C  +  +  C+GC  AI    Q V Y    WH 
Sbjct: 65  CFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVWH- 123

Query: 376 STECFLCSCCSKCLIGQKFMPVEGMVFCSVEC 407
             +CF CS C + +    F P +G  F  V C
Sbjct: 124 -KDCFTCSNCKQVIGTGSFFP-KGEDFYCVTC 153



 Score = 55.8 bits (133), Expect = 7e-08
 Identities = 31/102 (30%), Positives = 44/102 (43%), Gaps = 4/102 (3%)

Query: 249 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIF----SNEY 304
           D+ WH  CFVC TC + L    +    ++ YC   Y +    +CAGC   I      +  
Sbjct: 178 DQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSV 237

Query: 305 TQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVK 346
              E Q+WH   F C  C   LA + +V   ++  C  C  K
Sbjct: 238 VAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKK 279


>gi|228480209 four and a half LIM domains 1 isoform 3 [Homo sapiens]
          Length = 309

 Score = 93.6 bits (231), Expect = 3e-19
 Identities = 47/162 (29%), Positives = 77/162 (47%), Gaps = 6/162 (3%)

Query: 249 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGC-DELIFSNEYTQA 307
           ++ WH  CF C+ C   L +  +  K+ K+ C +     + P+C GC   ++  ++  + 
Sbjct: 87  NRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEY 146

Query: 308 ENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVT 367
           +   WH   F C +C  ++    +    +   C  C+    A  C  C+ AI      +T
Sbjct: 147 KGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITS--GGIT 204

Query: 368 YNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKK 409
           Y +  WHA  +CF+C  CSK L GQ+F  VE   +C V+C K
Sbjct: 205 YQDQPWHA--DCFVCVTCSKKLAGQRFTAVEDQYYC-VDCYK 243



 Score = 92.0 bits (227), Expect = 9e-19
 Identities = 53/164 (32%), Positives = 74/164 (45%), Gaps = 7/164 (4%)

Query: 251 LWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQ 310
           +WH  CF CS C +++    +F K E  YC   +       C  C++ I S   T  ++Q
Sbjct: 150 VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITY-QDQ 208

Query: 311 NWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAI---DPEVQRVT 367
            WH   F C  C   LAG+ +  V D+  C  CY    A  C GC N I         V 
Sbjct: 209 PWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVA 268

Query: 368 YNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKRM 411
           Y   SWH    CF C  CS  L  ++F+  +  V+C  +C K++
Sbjct: 269 YEGQSWH--DYCFHCKKCSVNLANKRFVFHQEQVYCP-DCAKKL 309



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 44/152 (28%), Positives = 65/152 (42%), Gaps = 4/152 (2%)

Query: 257 FVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSN-EYTQAENQNWHLK 315
           F C  C + L    Y  K+    C + +       C  C + I ++ +    +N+ WH  
Sbjct: 34  FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 93

Query: 316 HFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHA 375
            F C  C   LA E +V  ++K +C  C  +  +  C+GC  AI    Q V Y    WH 
Sbjct: 94  CFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVWH- 152

Query: 376 STECFLCSCCSKCLIGQKFMPVEGMVFCSVEC 407
             +CF CS C + +    F P +G  F  V C
Sbjct: 153 -KDCFTCSNCKQVIGTGSFFP-KGEDFYCVTC 182



 Score = 55.8 bits (133), Expect = 7e-08
 Identities = 31/102 (30%), Positives = 44/102 (43%), Gaps = 4/102 (3%)

Query: 249 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIF----SNEY 304
           D+ WH  CFVC TC + L    +    ++ YC   Y +    +CAGC   I      +  
Sbjct: 207 DQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSV 266

Query: 305 TQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVK 346
              E Q+WH   F C  C   LA + +V   ++  C  C  K
Sbjct: 267 VAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKK 308


>gi|228480205 four and a half LIM domains 1 isoform 5 [Homo sapiens]
          Length = 296

 Score = 93.6 bits (231), Expect = 3e-19
 Identities = 47/162 (29%), Positives = 77/162 (47%), Gaps = 6/162 (3%)

Query: 249 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGC-DELIFSNEYTQA 307
           ++ WH  CF C+ C   L +  +  K+ K+ C +     + P+C GC   ++  ++  + 
Sbjct: 74  NRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEY 133

Query: 308 ENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVT 367
           +   WH   F C +C  ++    +    +   C  C+    A  C  C+ AI      +T
Sbjct: 134 KGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITS--GGIT 191

Query: 368 YNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKK 409
           Y +  WHA  +CF+C  CSK L GQ+F  VE   +C V+C K
Sbjct: 192 YQDQPWHA--DCFVCVTCSKKLAGQRFTAVEDQYYC-VDCYK 230



 Score = 92.0 bits (227), Expect = 9e-19
 Identities = 53/164 (32%), Positives = 74/164 (45%), Gaps = 7/164 (4%)

Query: 251 LWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQ 310
           +WH  CF CS C +++    +F K E  YC   +       C  C++ I S   T  ++Q
Sbjct: 137 VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITY-QDQ 195

Query: 311 NWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAI---DPEVQRVT 367
            WH   F C  C   LAG+ +  V D+  C  CY    A  C GC N I         V 
Sbjct: 196 PWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVA 255

Query: 368 YNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKRM 411
           Y   SWH    CF C  CS  L  ++F+  +  V+C  +C K++
Sbjct: 256 YEGQSWH--DYCFHCKKCSVNLANKRFVFHQEQVYCP-DCAKKL 296



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 44/152 (28%), Positives = 65/152 (42%), Gaps = 4/152 (2%)

Query: 257 FVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSN-EYTQAENQNWHLK 315
           F C  C + L    Y  K+    C + +       C  C + I ++ +    +N+ WH  
Sbjct: 21  FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 80

Query: 316 HFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHA 375
            F C  C   LA E +V  ++K +C  C  +  +  C+GC  AI    Q V Y    WH 
Sbjct: 81  CFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVWH- 139

Query: 376 STECFLCSCCSKCLIGQKFMPVEGMVFCSVEC 407
             +CF CS C + +    F P +G  F  V C
Sbjct: 140 -KDCFTCSNCKQVIGTGSFFP-KGEDFYCVTC 169



 Score = 55.8 bits (133), Expect = 7e-08
 Identities = 31/102 (30%), Positives = 44/102 (43%), Gaps = 4/102 (3%)

Query: 249 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIF----SNEY 304
           D+ WH  CFVC TC + L    +    ++ YC   Y +    +CAGC   I      +  
Sbjct: 194 DQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSV 253

Query: 305 TQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVK 346
              E Q+WH   F C  C   LA + +V   ++  C  C  K
Sbjct: 254 VAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKK 295


>gi|21361122 four and a half LIM domains 1 isoform 2 [Homo sapiens]
          Length = 280

 Score = 93.6 bits (231), Expect = 3e-19
 Identities = 47/162 (29%), Positives = 77/162 (47%), Gaps = 6/162 (3%)

Query: 249 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGC-DELIFSNEYTQA 307
           ++ WH  CF C+ C   L +  +  K+ K+ C +     + P+C GC   ++  ++  + 
Sbjct: 58  NRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEY 117

Query: 308 ENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVT 367
           +   WH   F C +C  ++    +    +   C  C+    A  C  C+ AI      +T
Sbjct: 118 KGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITS--GGIT 175

Query: 368 YNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKK 409
           Y +  WHA  +CF+C  CSK L GQ+F  VE   +C V+C K
Sbjct: 176 YQDQPWHA--DCFVCVTCSKKLAGQRFTAVEDQYYC-VDCYK 214



 Score = 92.0 bits (227), Expect = 9e-19
 Identities = 53/164 (32%), Positives = 74/164 (45%), Gaps = 7/164 (4%)

Query: 251 LWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQ 310
           +WH  CF CS C +++    +F K E  YC   +       C  C++ I S   T  ++Q
Sbjct: 121 VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITY-QDQ 179

Query: 311 NWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAI---DPEVQRVT 367
            WH   F C  C   LAG+ +  V D+  C  CY    A  C GC N I         V 
Sbjct: 180 PWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVA 239

Query: 368 YNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKRM 411
           Y   SWH    CF C  CS  L  ++F+  +  V+C  +C K++
Sbjct: 240 YEGQSWH--DYCFHCKKCSVNLANKRFVFHQEQVYCP-DCAKKL 280



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 44/152 (28%), Positives = 65/152 (42%), Gaps = 4/152 (2%)

Query: 257 FVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSN-EYTQAENQNWHLK 315
           F C  C + L    Y  K+    C + +       C  C + I ++ +    +N+ WH  
Sbjct: 5   FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 64

Query: 316 HFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHA 375
            F C  C   LA E +V  ++K +C  C  +  +  C+GC  AI    Q V Y    WH 
Sbjct: 65  CFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVWH- 123

Query: 376 STECFLCSCCSKCLIGQKFMPVEGMVFCSVEC 407
             +CF CS C + +    F P +G  F  V C
Sbjct: 124 -KDCFTCSNCKQVIGTGSFFP-KGEDFYCVTC 153



 Score = 55.8 bits (133), Expect = 7e-08
 Identities = 31/102 (30%), Positives = 44/102 (43%), Gaps = 4/102 (3%)

Query: 249 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIF----SNEY 304
           D+ WH  CFVC TC + L    +    ++ YC   Y +    +CAGC   I      +  
Sbjct: 178 DQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSV 237

Query: 305 TQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVK 346
              E Q+WH   F C  C   LA + +V   ++  C  C  K
Sbjct: 238 VAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKK 279


>gi|170932518 paxillin isoform 3 [Homo sapiens]
          Length = 424

 Score = 85.9 bits (211), Expect = 6e-17
 Identities = 49/161 (30%), Positives = 72/161 (44%), Gaps = 5/161 (3%)

Query: 250 KLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAEN 309
           K WHP  FVC+ C E +    +F ++ + YC + Y +   PRC  C+  I     T A +
Sbjct: 208 KTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVT-ALD 266

Query: 310 QNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYN 369
           + WH +HF C  C +    E +   + K  C+  Y    A  C GC  AI      ++  
Sbjct: 267 RTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENY--ISAL 324

Query: 370 NFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKR 410
           N  WH   ECF+C  C    +   F   +G  +C V   +R
Sbjct: 325 NTLWH--PECFVCRECFTPFVNGSFFEHDGQPYCEVHYHER 363



 Score = 75.5 bits (184), Expect = 8e-14
 Identities = 47/177 (26%), Positives = 66/177 (37%), Gaps = 11/177 (6%)

Query: 227 CYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCD 286
           CY C        P +       D+ WHP  F C+ C        +  K+ K YC + Y D
Sbjct: 250 CYYCN------GPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFD 303

Query: 287 SEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVK 346
              P+C GC   I  N Y  A N  WH + F C +C +      +   + +P C+  Y +
Sbjct: 304 MFAPKCGGCARAILEN-YISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHE 362

Query: 347 NHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFC 403
               +C GC   I           F      E F+C+ C K L    F       +C
Sbjct: 363 RRGSLCSGCQKPITGRCITAMAKKF----HPEHFVCAFCLKQLNKGTFKEQNDKPYC 415



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 34/96 (35%), Positives = 48/96 (50%), Gaps = 1/96 (1%)

Query: 251 LWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQ 310
           LWHP CFVC  C    V+  +F  + + YC  HY +     C+GC + I     T A  +
Sbjct: 327 LWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCIT-AMAK 385

Query: 311 NWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVK 346
            +H +HF C  C   L    +   NDKP C+ C++K
Sbjct: 386 KFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLK 421



 Score = 45.4 bits (106), Expect = 9e-05
 Identities = 28/112 (25%), Positives = 47/112 (41%), Gaps = 5/112 (4%)

Query: 292 CAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVV 351
           C  C + I + +   A  + WH +HF C  C   +    +   + +P C+  Y    +  
Sbjct: 191 CGACKKPI-AGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPR 249

Query: 352 CQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFC 403
           C  C+  I  +V  VT  + +WH   E F C+ C      + F   +G  +C
Sbjct: 250 CYYCNGPILDKV--VTALDRTWH--PEHFFCAQCGAFFGPEGFHEKDGKAYC 297


>gi|170932516 paxillin isoform 2 [Homo sapiens]
          Length = 557

 Score = 85.9 bits (211), Expect = 6e-17
 Identities = 49/161 (30%), Positives = 72/161 (44%), Gaps = 5/161 (3%)

Query: 250 KLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAEN 309
           K WHP  FVC+ C E +    +F ++ + YC + Y +   PRC  C+  I     T A +
Sbjct: 341 KTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVT-ALD 399

Query: 310 QNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYN 369
           + WH +HF C  C +    E +   + K  C+  Y    A  C GC  AI      ++  
Sbjct: 400 RTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENY--ISAL 457

Query: 370 NFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKR 410
           N  WH   ECF+C  C    +   F   +G  +C V   +R
Sbjct: 458 NTLWH--PECFVCRECFTPFVNGSFFEHDGQPYCEVHYHER 496



 Score = 75.5 bits (184), Expect = 8e-14
 Identities = 47/177 (26%), Positives = 66/177 (37%), Gaps = 11/177 (6%)

Query: 227 CYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCD 286
           CY C        P +       D+ WHP  F C+ C        +  K+ K YC + Y D
Sbjct: 383 CYYCN------GPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFD 436

Query: 287 SEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVK 346
              P+C GC   I  N Y  A N  WH + F C +C +      +   + +P C+  Y +
Sbjct: 437 MFAPKCGGCARAILEN-YISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHE 495

Query: 347 NHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFC 403
               +C GC   I           F      E F+C+ C K L    F       +C
Sbjct: 496 RRGSLCSGCQKPITGRCITAMAKKF----HPEHFVCAFCLKQLNKGTFKEQNDKPYC 548



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 34/96 (35%), Positives = 48/96 (50%), Gaps = 1/96 (1%)

Query: 251 LWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQ 310
           LWHP CFVC  C    V+  +F  + + YC  HY +     C+GC + I     T A  +
Sbjct: 460 LWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCIT-AMAK 518

Query: 311 NWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVK 346
            +H +HF C  C   L    +   NDKP C+ C++K
Sbjct: 519 KFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLK 554



 Score = 45.4 bits (106), Expect = 9e-05
 Identities = 28/112 (25%), Positives = 47/112 (41%), Gaps = 5/112 (4%)

Query: 292 CAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVV 351
           C  C + I + +   A  + WH +HF C  C   +    +   + +P C+  Y    +  
Sbjct: 324 CGACKKPI-AGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPR 382

Query: 352 CQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFC 403
           C  C+  I  +V  VT  + +WH   E F C+ C      + F   +G  +C
Sbjct: 383 CYYCNGPILDKV--VTALDRTWH--PEHFFCAQCGAFFGPEGFHEKDGKAYC 430


>gi|170932514 paxillin isoform 1 [Homo sapiens]
          Length = 591

 Score = 85.9 bits (211), Expect = 6e-17
 Identities = 49/161 (30%), Positives = 72/161 (44%), Gaps = 5/161 (3%)

Query: 250 KLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAEN 309
           K WHP  FVC+ C E +    +F ++ + YC + Y +   PRC  C+  I     T A +
Sbjct: 375 KTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVT-ALD 433

Query: 310 QNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYN 369
           + WH +HF C  C +    E +   + K  C+  Y    A  C GC  AI      ++  
Sbjct: 434 RTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENY--ISAL 491

Query: 370 NFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKR 410
           N  WH   ECF+C  C    +   F   +G  +C V   +R
Sbjct: 492 NTLWH--PECFVCRECFTPFVNGSFFEHDGQPYCEVHYHER 530



 Score = 75.5 bits (184), Expect = 8e-14
 Identities = 47/177 (26%), Positives = 66/177 (37%), Gaps = 11/177 (6%)

Query: 227 CYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCD 286
           CY C        P +       D+ WHP  F C+ C        +  K+ K YC + Y D
Sbjct: 417 CYYCN------GPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFD 470

Query: 287 SEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVK 346
              P+C GC   I  N Y  A N  WH + F C +C +      +   + +P C+  Y +
Sbjct: 471 MFAPKCGGCARAILEN-YISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHE 529

Query: 347 NHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFC 403
               +C GC   I           F      E F+C+ C K L    F       +C
Sbjct: 530 RRGSLCSGCQKPITGRCITAMAKKF----HPEHFVCAFCLKQLNKGTFKEQNDKPYC 582



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 34/96 (35%), Positives = 48/96 (50%), Gaps = 1/96 (1%)

Query: 251 LWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQ 310
           LWHP CFVC  C    V+  +F  + + YC  HY +     C+GC + I     T A  +
Sbjct: 494 LWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCIT-AMAK 552

Query: 311 NWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVK 346
            +H +HF C  C   L    +   NDKP C+ C++K
Sbjct: 553 KFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLK 588



 Score = 45.4 bits (106), Expect = 9e-05
 Identities = 28/112 (25%), Positives = 47/112 (41%), Gaps = 5/112 (4%)

Query: 292 CAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVV 351
           C  C + I + +   A  + WH +HF C  C   +    +   + +P C+  Y    +  
Sbjct: 358 CGACKKPI-AGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPR 416

Query: 352 CQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFC 403
           C  C+  I  +V  VT  + +WH   E F C+ C      + F   +G  +C
Sbjct: 417 CYYCNGPILDKV--VTALDRTWH--PEHFFCAQCGAFFGPEGFHEKDGKAYC 464


>gi|221316659 leupaxin isoform 1 [Homo sapiens]
          Length = 391

 Score = 85.9 bits (211), Expect = 6e-17
 Identities = 47/159 (29%), Positives = 69/159 (43%), Gaps = 5/159 (3%)

Query: 252 WHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQN 311
           WHP  FVC+ C E +    +F ++   YC   Y     PRCA C   I     T A NQ 
Sbjct: 176 WHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSPRCAYCAAPILDKVLT-AMNQT 234

Query: 312 WHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNF 371
           WH +HF C  C  +   E +   + KP C+  ++   +  C GC+  +      ++  + 
Sbjct: 235 WHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVLENY--LSAMDT 292

Query: 372 SWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKR 410
            WH   ECF+C  C        F  ++G  FC +    R
Sbjct: 293 VWH--PECFVCGDCFTSFSTGSFFELDGRPFCELHYHHR 329



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 40/155 (25%), Positives = 68/155 (43%), Gaps = 5/155 (3%)

Query: 249 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAE 308
           ++ WHP  F CS C E+     +  K++K YC + +     P+C GC+  +  N Y  A 
Sbjct: 232 NQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVLEN-YLSAM 290

Query: 309 NQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTY 368
           +  WH + F C DC +  +   +  ++ +P C+  Y      +C GC   I      ++ 
Sbjct: 291 DTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGTLCHGCGQPITGRC--ISA 348

Query: 369 NNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFC 403
             + +H   E F+C+ C   L    F       +C
Sbjct: 349 MGYKFH--PEHFVCAFCLTQLSKGIFREQNDKTYC 381



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 33/108 (30%), Positives = 49/108 (45%), Gaps = 1/108 (0%)

Query: 239 PAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDEL 298
           P +    +  D +WHP CFVC  C        +F  + + +C  HY       C GC + 
Sbjct: 281 PVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGTLCHGCGQP 340

Query: 299 IFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVK 346
           I +     A    +H +HF C  C + L+  I+   NDK  C+PC+ K
Sbjct: 341 I-TGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQPCFNK 387



 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 30/115 (26%), Positives = 47/115 (40%), Gaps = 5/115 (4%)

Query: 289 KPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNH 348
           K  CA C + I + +   A  Q+WH +HF C  C   +    +   +    C   Y +  
Sbjct: 154 KGHCASCQKPI-AGKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLF 212

Query: 349 AVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFC 403
           +  C  C   I  +V  +T  N +WH   E F CS C +    + F   +   +C
Sbjct: 213 SPRCAYCAAPILDKV--LTAMNQTWH--PEHFFCSHCGEVFGAEGFHEKDKKPYC 263


>gi|4758670 leupaxin isoform 2 [Homo sapiens]
          Length = 386

 Score = 85.9 bits (211), Expect = 6e-17
 Identities = 47/159 (29%), Positives = 69/159 (43%), Gaps = 5/159 (3%)

Query: 252 WHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQN 311
           WHP  FVC+ C E +    +F ++   YC   Y     PRCA C   I     T A NQ 
Sbjct: 171 WHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSPRCAYCAAPILDKVLT-AMNQT 229

Query: 312 WHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNF 371
           WH +HF C  C  +   E +   + KP C+  ++   +  C GC+  +      ++  + 
Sbjct: 230 WHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVLENY--LSAMDT 287

Query: 372 SWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKR 410
            WH   ECF+C  C        F  ++G  FC +    R
Sbjct: 288 VWH--PECFVCGDCFTSFSTGSFFELDGRPFCELHYHHR 324



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 40/155 (25%), Positives = 68/155 (43%), Gaps = 5/155 (3%)

Query: 249 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAE 308
           ++ WHP  F CS C E+     +  K++K YC + +     P+C GC+  +  N Y  A 
Sbjct: 227 NQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVLEN-YLSAM 285

Query: 309 NQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTY 368
           +  WH + F C DC +  +   +  ++ +P C+  Y      +C GC   I      ++ 
Sbjct: 286 DTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGTLCHGCGQPITGRC--ISA 343

Query: 369 NNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFC 403
             + +H   E F+C+ C   L    F       +C
Sbjct: 344 MGYKFH--PEHFVCAFCLTQLSKGIFREQNDKTYC 376



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 33/108 (30%), Positives = 49/108 (45%), Gaps = 1/108 (0%)

Query: 239 PAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDEL 298
           P +    +  D +WHP CFVC  C        +F  + + +C  HY       C GC + 
Sbjct: 276 PVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGTLCHGCGQP 335

Query: 299 IFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVK 346
           I +     A    +H +HF C  C + L+  I+   NDK  C+PC+ K
Sbjct: 336 I-TGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQPCFNK 382



 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 30/115 (26%), Positives = 47/115 (40%), Gaps = 5/115 (4%)

Query: 289 KPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNH 348
           K  CA C + I + +   A  Q+WH +HF C  C   +    +   +    C   Y +  
Sbjct: 149 KGHCASCQKPI-AGKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLF 207

Query: 349 AVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFC 403
           +  C  C   I  +V  +T  N +WH   E F CS C +    + F   +   +C
Sbjct: 208 SPRCAYCAAPILDKV--LTAMNQTWH--PEHFFCSHCGEVFGAEGFHEKDKKPYC 258


>gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens]
          Length = 617

 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 43/152 (28%), Positives = 65/152 (42%), Gaps = 3/152 (1%)

Query: 252 WHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQN 311
           WHP  F C+ C   L D+ +  +   +YC R Y     P CA C+  I   E   A  Q 
Sbjct: 460 WHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMG-EVMHALRQT 518

Query: 312 WHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNF 371
           WH   F C  C       ++ M + +P C+  Y+   +  C GC   ++   + +     
Sbjct: 519 WHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGH 578

Query: 372 SWHASTECFLCSCCSKCLIGQKFMPVEGMVFC 403
           +WH +  CF+C+ C   L GQ F   +    C
Sbjct: 579 TWHDT--CFICAVCHVNLEGQPFYSKKDRPLC 608



 Score = 62.8 bits (151), Expect = 6e-10
 Identities = 31/114 (27%), Positives = 55/114 (48%), Gaps = 5/114 (4%)

Query: 229 CCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSE 288
           C K + K     ++A R    + WH  CFVC+ C +   + ++  ++ + YC + Y +  
Sbjct: 500 CAKCNTKIMGEVMHALR----QTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLF 555

Query: 289 KPRCAGCD-ELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCK 341
             +C GCD  +   +++ +A    WH   F C  C   L G+ +    D+P+CK
Sbjct: 556 STKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCK 609



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 35/122 (28%), Positives = 53/122 (43%), Gaps = 5/122 (4%)

Query: 282 RHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCK 341
           R    S  P C  C+ +I    +  A  ++WH + F C  C + LA   +V   +   C+
Sbjct: 431 RFPASSRTPLCGHCNNVI-RGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCE 489

Query: 342 PCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMV 401
            CY +  A +C  C+  I  EV        +WH  T CF+C+ C K      F   +G  
Sbjct: 490 RCYEQFFAPLCAKCNTKIMGEVMHALRQ--TWH--TTCFVCAACKKPFGNSLFHMEDGEP 545

Query: 402 FC 403
           +C
Sbjct: 546 YC 547



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 18/57 (31%), Positives = 29/57 (50%), Gaps = 4/57 (7%)

Query: 227 CYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRH 283
           C+ C   ++ GD  I  E  G+   WH  CF+C+ CH  L    ++ K ++  C +H
Sbjct: 559 CHGCDFPVEAGDKFI--EALGHT--WHDTCFICAVCHVNLEGQPFYSKKDRPLCKKH 611


>gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]
          Length = 727

 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 43/152 (28%), Positives = 65/152 (42%), Gaps = 3/152 (1%)

Query: 252 WHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQN 311
           WHP  F C+ C   L D+ +  +   +YC R Y     P CA C+  I   E   A  Q 
Sbjct: 570 WHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMG-EVMHALRQT 628

Query: 312 WHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNF 371
           WH   F C  C       ++ M + +P C+  Y+   +  C GC   ++   + +     
Sbjct: 629 WHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGH 688

Query: 372 SWHASTECFLCSCCSKCLIGQKFMPVEGMVFC 403
           +WH +  CF+C+ C   L GQ F   +    C
Sbjct: 689 TWHDT--CFICAVCHVNLEGQPFYSKKDRPLC 718



 Score = 62.8 bits (151), Expect = 6e-10
 Identities = 31/114 (27%), Positives = 55/114 (48%), Gaps = 5/114 (4%)

Query: 229 CCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSE 288
           C K + K     ++A R    + WH  CFVC+ C +   + ++  ++ + YC + Y +  
Sbjct: 610 CAKCNTKIMGEVMHALR----QTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLF 665

Query: 289 KPRCAGCD-ELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCK 341
             +C GCD  +   +++ +A    WH   F C  C   L G+ +    D+P+CK
Sbjct: 666 STKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCK 719



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 35/122 (28%), Positives = 53/122 (43%), Gaps = 5/122 (4%)

Query: 282 RHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCK 341
           R    S  P C  C+ +I    +  A  ++WH + F C  C + LA   +V   +   C+
Sbjct: 541 RFPASSRTPLCGHCNNVI-RGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCE 599

Query: 342 PCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMV 401
            CY +  A +C  C+  I  EV        +WH  T CF+C+ C K      F   +G  
Sbjct: 600 RCYEQFFAPLCAKCNTKIMGEVMHALRQ--TWH--TTCFVCAACKKPFGNSLFHMEDGEP 655

Query: 402 FC 403
           +C
Sbjct: 656 YC 657



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 18/57 (31%), Positives = 29/57 (50%), Gaps = 4/57 (7%)

Query: 227 CYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRH 283
           C+ C   ++ GD  I  E  G+   WH  CF+C+ CH  L    ++ K ++  C +H
Sbjct: 669 CHGCDFPVEAGDKFI--EALGHT--WHDTCFICAVCHVNLEGQPFYSKKDRPLCKKH 721


>gi|54112385 four and a half LIM domains 3 [Homo sapiens]
          Length = 280

 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 47/154 (30%), Positives = 70/154 (45%), Gaps = 5/154 (3%)

Query: 252 WHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQN 311
           WH  CF+CS C + L    +       YC   Y +   PRCA C + +     T  + Q 
Sbjct: 122 WHEHCFLCSGCEQPLGSRSFVPDKGAHYCVPCYENKFAPRCARCSKTLTQGGVTYRD-QP 180

Query: 312 WHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAID--PEVQRVTYN 369
           WH +   C  C + LAG+ +   ++ P C  C+ +  A  C  C   I      + V++ 
Sbjct: 181 WHRECLVCTGCQTPLAGQQFTSRDEDPYCVACFGELFAPKCSSCKRPIVGLGGGKYVSFE 240

Query: 370 NFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFC 403
           +  WH +  CF C+ CS  L+GQ F+P    V C
Sbjct: 241 DRHWHHN--CFSCARCSTSLVGQGFVPDGDQVLC 272



 Score = 82.4 bits (202), Expect = 7e-16
 Identities = 44/156 (28%), Positives = 65/156 (41%), Gaps = 5/156 (3%)

Query: 249 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIF-SNEYTQA 307
           D+ +H  CF C  C   L D  +  ++ +L C   YC +   +C+ C E +   +   + 
Sbjct: 58  DRHFHEGCFRCCRCQRSLADEPFTCQDSELLCNDCYCSAFSSQCSACGETVMPGSRKLEY 117

Query: 308 ENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVT 367
             Q WH   F C  C+  L    +V       C PCY    A  C  C   +      VT
Sbjct: 118 GGQTWHEHCFLCSGCEQPLGSRSFVPDKGAHYCVPCYENKFAPRCARCSKTLTQ--GGVT 175

Query: 368 YNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFC 403
           Y +  WH   EC +C+ C   L GQ+F   +   +C
Sbjct: 176 YRDQPWH--RECLVCTGCQTPLAGQQFTSRDEDPYC 209



 Score = 75.5 bits (184), Expect = 8e-14
 Identities = 42/148 (28%), Positives = 68/148 (45%), Gaps = 3/148 (2%)

Query: 257 FVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELI-FSNEYTQAENQNWHLK 315
           F C+ C+E L    Y   +   YC   Y ++    CA C +LI   +     E++++H  
Sbjct: 5   FDCAKCNESLYGRKYIQTDSGPYCVPCYDNTFANTCAECQQLIGHDSRELFYEDRHFHEG 64

Query: 316 HFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHA 375
            F C  C   LA E +   + + +C  CY    +  C  C   + P  +++ Y   +WH 
Sbjct: 65  CFRCCRCQRSLADEPFTCQDSELLCNDCYCSAFSSQCSACGETVMPGSRKLEYGGQTWH- 123

Query: 376 STECFLCSCCSKCLIGQKFMPVEGMVFC 403
              CFLCS C + L  + F+P +G  +C
Sbjct: 124 -EHCFLCSGCEQPLGSRSFVPDKGAHYC 150



 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 28/98 (28%), Positives = 47/98 (47%), Gaps = 3/98 (3%)

Query: 249 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIF---SNEYT 305
           D+ WH  C VC+ C   L    +  ++E  YC   + +   P+C+ C   I      +Y 
Sbjct: 178 DQPWHRECLVCTGCQTPLAGQQFTSRDEDPYCVACFGELFAPKCSSCKRPIVGLGGGKYV 237

Query: 306 QAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPC 343
             E+++WH   F C  C + L G+ +V   D+ +C+ C
Sbjct: 238 SFEDRHWHHNCFSCARCSTSLVGQGFVPDGDQVLCQGC 275



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 24/88 (27%), Positives = 37/88 (42%), Gaps = 2/88 (2%)

Query: 317 FCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHAS 376
           F C  C+  L G  Y+  +  P C PCY    A  C  C   I  + + + Y +  +H  
Sbjct: 5   FDCAKCNESLYGRKYIQTDSGPYCVPCYDNTFANTCAECQQLIGHDSRELFYEDRHFHEG 64

Query: 377 TECFLCSCCSKCLIGQKFMPVEGMVFCS 404
             CF C  C + L  + F   +  + C+
Sbjct: 65  --CFRCCRCQRSLADEPFTCQDSELLCN 90


>gi|30410801 activator of cAMP-responsive element modulator (CREM)
           in testis [Homo sapiens]
          Length = 284

 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 46/156 (29%), Positives = 69/156 (44%), Gaps = 5/156 (3%)

Query: 249 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIF-SNEYTQA 307
           D+ WH  CF C+ C+  LV+  +  K+E+L C   Y +    +C  C   I   +   + 
Sbjct: 59  DRHWHEGCFKCTKCNHSLVEKPFAAKDERLLCTECYSNECSSKCFHCKRTIMPGSRKMEF 118

Query: 308 ENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVT 367
           +   WH   F C +C   +  +  +       C PC+ K  A  C  C   I      +T
Sbjct: 119 KGNYWHETCFVCENCRQPIGTKPLISKESGNYCVPCFEKEFAHYCNFCKKVITS--GGIT 176

Query: 368 YNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFC 403
           + +  WH   ECFLCS C K L  ++FM  +   FC
Sbjct: 177 FCDQLWH--KECFLCSGCRKDLCEEQFMSRDDYPFC 210



 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 49/179 (27%), Positives = 74/179 (41%), Gaps = 9/179 (5%)

Query: 227 CYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCD 286
           C+ CK ++  G   +  +       WH  CFVC  C + +       K    YC   +  
Sbjct: 102 CFHCKRTIMPGSRKMEFK----GNYWHETCFVCENCRQPIGTKPLISKESGNYCVPCFEK 157

Query: 287 SEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVK 346
                C  C ++I S   T  + Q WH + F C  C   L  E ++  +D P C  CY  
Sbjct: 158 EFAHYCNFCKKVITSGGITFCD-QLWHKECFLCSGCRKDLCEEQFMSRDDYPFCMDCYNH 216

Query: 347 NHAVVCQGCHNAID--PEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFC 403
            +A  C  C   I      + + + +  WH  +ECF C  CS  L+G+ F+     +FC
Sbjct: 217 LYANKCVACSKPISGLTGAKFICFQDSQWH--SECFNCGKCSVSLVGKGFLTQNKEIFC 273



 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 28/92 (30%), Positives = 47/92 (51%), Gaps = 3/92 (3%)

Query: 316 HFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHA 375
           HF C  C + L G+ YV+ +D P C  CY +  +  C+ C   I+ + + + Y +  WH 
Sbjct: 5   HFYCQYCTASLLGKKYVLKDDSPYCVTCYDRVFSNYCEECKKPIESDSKDLCYKDRHWHE 64

Query: 376 STECFLCSCCSKCLIGQKFMPVEGMVFCSVEC 407
              CF C+ C+  L+ + F   +  + C+ EC
Sbjct: 65  G--CFKCTKCNHSLVEKPFAAKDERLLCT-EC 93



 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 35/150 (23%), Positives = 63/150 (42%), Gaps = 3/150 (2%)

Query: 255 ACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQA-ENQNWH 313
           A F C  C   L+   Y  K++  YC   Y       C  C + I S+      ++++WH
Sbjct: 4   AHFYCQYCTASLLGKKYVLKDDSPYCVTCYDRVFSNYCEECKKPIESDSKDLCYKDRHWH 63

Query: 314 LKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSW 373
              F C  C+  L  + +   +++ +C  CY    +  C  C   I P  +++ +    W
Sbjct: 64  EGCFKCTKCNHSLVEKPFAAKDERLLCTECYSNECSSKCFHCKRTIMPGSRKMEFKGNYW 123

Query: 374 HASTECFLCSCCSKCLIGQKFMPVEGMVFC 403
           H +  CF+C  C + +  +  +  E   +C
Sbjct: 124 HET--CFVCENCRQPIGTKPLISKESGNYC 151



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 25/98 (25%), Positives = 46/98 (46%), Gaps = 3/98 (3%)

Query: 249 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELI---FSNEYT 305
           D+LWH  CF+CS C + L +  +  +++  +C   Y      +C  C + I      ++ 
Sbjct: 179 DQLWHKECFLCSGCRKDLCEEQFMSRDDYPFCMDCYNHLYANKCVACSKPISGLTGAKFI 238

Query: 306 QAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPC 343
             ++  WH + F C  C   L G+ ++  N +  C+ C
Sbjct: 239 CFQDSQWHSECFNCGKCSVSLVGKGFLTQNKEIFCQKC 276


>gi|109638745 transforming growth factor beta 1 induced transcript 1
           isoform 1 [Homo sapiens]
          Length = 461

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 60/238 (25%), Positives = 92/238 (38%), Gaps = 23/238 (9%)

Query: 180 VGDVKLPCEMDAQGPKQMNI-------------PGGDRSTPAAVGAME-DKSAEHKRTQY 225
           + D ++   + A GP Q  +             P G  S    +G ++ D S     TQ 
Sbjct: 165 LSDFRVQNHLPASGPTQPPVVSSTNEGSPSPPEPTGKGSLDTMLGLLQSDLSRRGVPTQA 224

Query: 226 SCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYC 285
              C   +       + A      + WHP  FVC  C   L    +F K+   +C   Y 
Sbjct: 225 KGLCGSCNKPIAGQVVTA----LGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYF 280

Query: 286 DSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYV 345
           +   PRC  C++ I  ++   A   +WH +HFCC  C      E +     +P C+  ++
Sbjct: 281 ERFSPRCGFCNQPI-RHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFL 339

Query: 346 KNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFC 403
           +  A  CQGC   I      ++  +  WH   +CF+C  C     G  F   EG   C
Sbjct: 340 QLFAPRCQGCQGPILDNY--ISALSALWH--PDCFVCRECFAPFSGGSFFEHEGRPLC 393



 Score = 62.0 bits (149), Expect = 9e-10
 Identities = 38/152 (25%), Positives = 58/152 (38%), Gaps = 5/152 (3%)

Query: 252 WHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQN 311
           WHP  F C +C E   D  +  +  + YC R +     PRC GC   I  N Y  A +  
Sbjct: 306 WHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDN-YISALSAL 364

Query: 312 WHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNF 371
           WH   F C +C +  +G  +     +P+C+  +      +C  C   +           F
Sbjct: 365 WHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSALGRRF 424

Query: 372 SWHASTECFLCSCCSKCLIGQKFMPVEGMVFC 403
                 + F C+ C + L    F    G  +C
Sbjct: 425 ----HPDHFTCTFCLRPLTKGSFQERAGKPYC 452



 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 29/96 (30%), Positives = 39/96 (40%), Gaps = 1/96 (1%)

Query: 251 LWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQ 310
           LWHP CFVC  C        +F    +  C  H+       CA C  L  +     A  +
Sbjct: 364 LWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCG-LPVTGRCVSALGR 422

Query: 311 NWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVK 346
            +H  HF C  C   L    +     KP C+PC++K
Sbjct: 423 RFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLK 458


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.135    0.444 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,642,601
Number of Sequences: 37866
Number of extensions: 844104
Number of successful extensions: 3072
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 106
Number of HSP's successfully gapped in prelim test: 50
Number of HSP's that attempted gapping in prelim test: 2309
Number of HSP's gapped (non-prelim): 428
length of query: 412
length of database: 18,247,518
effective HSP length: 105
effective length of query: 307
effective length of database: 14,271,588
effective search space: 4381377516
effective search space used: 4381377516
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.