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Search of human proteins with 23097246
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23097246 pyrin domain containing 1 [Homo sapiens]
(89 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23097246 pyrin domain containing 1 [Homo sapiens] 172 7e-44
gi|10835256 PYD and CARD domain containing isoform a [Homo sapiens] 107 2e-24
gi|22035620 PYD and CARD domain containing isoform b [Homo sapiens] 107 2e-24
gi|4557743 Mediterranean fever protein [Homo sapiens] 54 3e-08
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens] 47 2e-06
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens] 44 3e-05
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 40 4e-04
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 40 4e-04
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 40 4e-04
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 40 4e-04
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 40 4e-04
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 38 0.002
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 38 0.002
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 38 0.002
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 32 0.11
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 32 0.11
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 31 0.18
gi|133922598 pyrin domain containing 2 [Homo sapiens] 28 1.2
gi|62526045 zinc finger protein 638 [Homo sapiens] 26 5.9
gi|21626468 zinc finger protein 638 [Homo sapiens] 26 5.9
>gi|23097246 pyrin domain containing 1 [Homo sapiens]
Length = 89
Score = 172 bits (435), Expect = 7e-44
Identities = 89/89 (100%), Positives = 89/89 (100%)
Query: 1 MGTKREAILKVLENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLDIVDLTDKLVASY 60
MGTKREAILKVLENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLDIVDLTDKLVASY
Sbjct: 1 MGTKREAILKVLENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLDIVDLTDKLVASY 60
Query: 61 YEDYAAELVVAVLRDMRMLEEAARLQRAA 89
YEDYAAELVVAVLRDMRMLEEAARLQRAA
Sbjct: 61 YEDYAAELVVAVLRDMRMLEEAARLQRAA 89
>gi|10835256 PYD and CARD domain containing isoform a [Homo
sapiens]
Length = 195
Score = 107 bits (267), Expect = 2e-24
Identities = 57/88 (64%), Positives = 66/88 (75%)
Query: 1 MGTKREAILKVLENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLDIVDLTDKLVASY 60
MG R+AIL LENLT EELKKFK+KL +VPLREG+ RIPRGAL +D +DLTDKLV+ Y
Sbjct: 1 MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY 60
Query: 61 YEDYAAELVVAVLRDMRMLEEAARLQRA 88
E Y AEL VLRDM + E A +LQ A
Sbjct: 61 LETYGAELTANVLRDMGLQEMAGQLQAA 88
>gi|22035620 PYD and CARD domain containing isoform b [Homo
sapiens]
Length = 176
Score = 107 bits (267), Expect = 2e-24
Identities = 57/88 (64%), Positives = 66/88 (75%)
Query: 1 MGTKREAILKVLENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLDIVDLTDKLVASY 60
MG R+AIL LENLT EELKKFK+KL +VPLREG+ RIPRGAL +D +DLTDKLV+ Y
Sbjct: 1 MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY 60
Query: 61 YEDYAAELVVAVLRDMRMLEEAARLQRA 88
E Y AEL VLRDM + E A +LQ A
Sbjct: 61 LETYGAELTANVLRDMGLQEMAGQLQAA 88
>gi|4557743 Mediterranean fever protein [Homo sapiens]
Length = 781
Score = 53.5 bits (127), Expect = 3e-08
Identities = 31/87 (35%), Positives = 45/87 (51%)
Query: 3 TKREAILKVLENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLDIVDLTDKLVASYYE 62
T + +L LE L P + +KFK KL +++ RIPR + + V + LV Y E
Sbjct: 4 TPSDHLLSTLEELVPYDFEKFKFKLQNTSVQKEHSRIPRSQIQRARPVKMATLLVTYYGE 63
Query: 63 DYAAELVVAVLRDMRMLEEAARLQRAA 89
+YA +L + VLR + A L RAA
Sbjct: 64 EYAVQLTLQVLRAINQRLLAEELHRAA 90
>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
Length = 655
Score = 47.4 bits (111), Expect = 2e-06
Identities = 29/76 (38%), Positives = 42/76 (55%)
Query: 5 REAILKVLENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLDIVDLTDKLVASYYEDY 64
REA+L L +L + KK K L + L EG + RG L L VDL + L++ Y E
Sbjct: 10 REALLWALSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAELLISKYGEKE 69
Query: 65 AAELVVAVLRDMRMLE 80
A ++V+ L+ M +LE
Sbjct: 70 AVKVVLKGLKVMNLLE 85
>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
Length = 892
Score = 43.9 bits (102), Expect = 3e-05
Identities = 30/86 (34%), Positives = 44/86 (51%), Gaps = 2/86 (2%)
Query: 1 MGTKREAILKVLENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLDIVDLTDKLVASY 60
+ RE +L LE L+ E+LK+F+ KL V IP G L + D VDL ++L Y
Sbjct: 15 LAVARELLLAALEELSQEQLKRFRHKLRDV--GPDGRSIPWGRLERADAVDLAEQLAQFY 72
Query: 61 YEDYAAELVVAVLRDMRMLEEAARLQ 86
+ A E+ L+ + AA+LQ
Sbjct: 73 GPEPALEVARKTLKRADARDVAAQLQ 98
>gi|119395764 NLR family, pyrin domain containing 3 isoform a
[Homo sapiens]
Length = 1036
Score = 40.0 bits (92), Expect = 4e-04
Identities = 28/87 (32%), Positives = 44/87 (50%), Gaps = 3/87 (3%)
Query: 1 MGTKREAILKVLENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLDIVDLTDKLVASY 60
M + R + + LE+L +LKKFKM L P ++G +PRG + D VDL ++
Sbjct: 3 MASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFN 62
Query: 61 YEDYA---AELVVAVLRDMRMLEEAAR 84
E+ A A + A + + E+A R
Sbjct: 63 GEEKAWAMAVWIFAAINRRDLYEKAKR 89
>gi|188536116 NLR family, pyrin domain containing 3 isoform c
[Homo sapiens]
Length = 979
Score = 40.0 bits (92), Expect = 4e-04
Identities = 28/87 (32%), Positives = 44/87 (50%), Gaps = 3/87 (3%)
Query: 1 MGTKREAILKVLENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLDIVDLTDKLVASY 60
M + R + + LE+L +LKKFKM L P ++G +PRG + D VDL ++
Sbjct: 3 MASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFN 62
Query: 61 YEDYA---AELVVAVLRDMRMLEEAAR 84
E+ A A + A + + E+A R
Sbjct: 63 GEEKAWAMAVWIFAAINRRDLYEKAKR 89
>gi|188536002 NLR family, pyrin domain containing 3 isoform d
[Homo sapiens]
Length = 979
Score = 40.0 bits (92), Expect = 4e-04
Identities = 28/87 (32%), Positives = 44/87 (50%), Gaps = 3/87 (3%)
Query: 1 MGTKREAILKVLENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLDIVDLTDKLVASY 60
M + R + + LE+L +LKKFKM L P ++G +PRG + D VDL ++
Sbjct: 3 MASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFN 62
Query: 61 YEDYA---AELVVAVLRDMRMLEEAAR 84
E+ A A + A + + E+A R
Sbjct: 63 GEEKAWAMAVWIFAAINRRDLYEKAKR 89
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 40.0 bits (92), Expect = 4e-04
Identities = 28/87 (32%), Positives = 44/87 (50%), Gaps = 3/87 (3%)
Query: 1 MGTKREAILKVLENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLDIVDLTDKLVASY 60
M + R + + LE+L +LKKFKM L P ++G +PRG + D VDL ++
Sbjct: 3 MASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFN 62
Query: 61 YEDYA---AELVVAVLRDMRMLEEAAR 84
E+ A A + A + + E+A R
Sbjct: 63 GEEKAWAMAVWIFAAINRRDLYEKAKR 89
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 40.0 bits (92), Expect = 4e-04
Identities = 28/87 (32%), Positives = 44/87 (50%), Gaps = 3/87 (3%)
Query: 1 MGTKREAILKVLENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLDIVDLTDKLVASY 60
M + R + + LE+L +LKKFKM L P ++G +PRG + D VDL ++
Sbjct: 3 MASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFN 62
Query: 61 YEDYA---AELVVAVLRDMRMLEEAAR 84
E+ A A + A + + E+A R
Sbjct: 63 GEEKAWAMAVWIFAAINRRDLYEKAKR 89
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7
isoform 3 [Homo sapiens]
Length = 1037
Score = 37.7 bits (86), Expect = 0.002
Identities = 21/70 (30%), Positives = 35/70 (50%)
Query: 11 VLENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLDIVDLTDKLVASYYEDYAAELVV 70
+LE L +ELK FK L PL + ++ P + + D L + LV + E++ V
Sbjct: 13 LLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRNATV 72
Query: 71 AVLRDMRMLE 80
+L +M + E
Sbjct: 73 NILEEMNLTE 82
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7
isoform 2 [Homo sapiens]
Length = 980
Score = 37.7 bits (86), Expect = 0.002
Identities = 21/70 (30%), Positives = 35/70 (50%)
Query: 11 VLENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLDIVDLTDKLVASYYEDYAAELVV 70
+LE L +ELK FK L PL + ++ P + + D L + LV + E++ V
Sbjct: 13 LLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRNATV 72
Query: 71 AVLRDMRMLE 80
+L +M + E
Sbjct: 73 NILEEMNLTE 82
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7
isoform 1 [Homo sapiens]
Length = 1009
Score = 37.7 bits (86), Expect = 0.002
Identities = 21/70 (30%), Positives = 35/70 (50%)
Query: 11 VLENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLDIVDLTDKLVASYYEDYAAELVV 70
+LE L +ELK FK L PL + ++ P + + D L + LV + E++ V
Sbjct: 13 LLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRNATV 72
Query: 71 AVLRDMRMLE 80
+L +M + E
Sbjct: 73 NILEEMNLTE 82
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 32.0 bits (71), Expect = 0.11
Identities = 21/75 (28%), Positives = 37/75 (49%), Gaps = 3/75 (4%)
Query: 11 VLENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLD---IVDLTDKLVASYYEDYAAE 67
+LE L+ +EL KFK + T L ++IP + + D +V++ SY+ + A+
Sbjct: 14 LLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILTTHCDSYWVEMASL 73
Query: 68 LVVAVLRDMRMLEEA 82
V + M + E A
Sbjct: 74 QVFEKMHRMDLSERA 88
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2
[Homo sapiens]
Length = 1061
Score = 32.0 bits (71), Expect = 0.11
Identities = 24/77 (31%), Positives = 39/77 (50%), Gaps = 3/77 (3%)
Query: 12 LENLTPEELKKFKMKLGT-VPLREGFERIPRGALGQLDIVDLTDKLVASYYEDYAAELVV 70
LE L ELKKFK+ LGT L EG +IP G++ + +++ L+ + + A L +
Sbjct: 17 LEELEAVELKKFKLYLGTATELGEG--KIPWGSMEKAGPLEMAQLLITHFGPEEAWRLAL 74
Query: 71 AVLRDMRMLEEAARLQR 87
+ + + R QR
Sbjct: 75 STFERINRKDLWERGQR 91
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 31.2 bits (69), Expect = 0.18
Identities = 19/76 (25%), Positives = 36/76 (47%)
Query: 12 LENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLDIVDLTDKLVASYYEDYAAELVVA 71
LE L EE +KFK L + L+ ++IP + + +L + L+ Y E A + +
Sbjct: 15 LEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWNITLR 74
Query: 72 VLRDMRMLEEAARLQR 87
+ + M + ++ R
Sbjct: 75 IFQKMDRKDLCMKVMR 90
>gi|133922598 pyrin domain containing 2 [Homo sapiens]
Length = 97
Score = 28.5 bits (62), Expect = 1.2
Identities = 16/59 (27%), Positives = 32/59 (54%), Gaps = 3/59 (5%)
Query: 11 VLENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLD---IVDLTDKLVASYYEDYAA 66
+LE L+ +EL KFK + T+ L + + +P+ + + + +V++ SY+ AA
Sbjct: 14 LLEQLSQDELSKFKSLIRTISLGKELQTVPQTEVDKANGKQLVEIFTSHSCSYWAGMAA 72
>gi|62526045 zinc finger protein 638 [Homo sapiens]
Length = 1978
Score = 26.2 bits (56), Expect = 5.9
Identities = 24/85 (28%), Positives = 37/85 (43%), Gaps = 16/85 (18%)
Query: 10 KVLENLTPEELKKFKMK------LGTVPLRE-------GFERIPRGALGQLDIVDLTDKL 56
+V+E + P + K+ +K L VP E G PRG G+L V L +
Sbjct: 1546 EVIEEVNPSQAKQNPLKGKRKETLKNVPFSELNLKKKKGKTSTPRGVEGELSFVTLDE-- 1603
Query: 57 VASYYEDYAAELVVAVLRDMRMLEE 81
ED AA L A++ +++E
Sbjct: 1604 -IGEEEDAAAHLAQALVTVDEVIDE 1627
>gi|21626468 zinc finger protein 638 [Homo sapiens]
Length = 1978
Score = 26.2 bits (56), Expect = 5.9
Identities = 24/85 (28%), Positives = 37/85 (43%), Gaps = 16/85 (18%)
Query: 10 KVLENLTPEELKKFKMK------LGTVPLRE-------GFERIPRGALGQLDIVDLTDKL 56
+V+E + P + K+ +K L VP E G PRG G+L V L +
Sbjct: 1546 EVIEEVNPSQAKQNPLKGKRKETLKNVPFSELNLKKKKGKTSTPRGVEGELSFVTLDE-- 1603
Query: 57 VASYYEDYAAELVVAVLRDMRMLEE 81
ED AA L A++ +++E
Sbjct: 1604 -IGEEEDAAAHLAQALVTVDEVIDE 1627
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 2,626,743
Number of Sequences: 37866
Number of extensions: 91224
Number of successful extensions: 283
Number of sequences better than 10.0: 20
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 266
Number of HSP's gapped (non-prelim): 20
length of query: 89
length of database: 18,247,518
effective HSP length: 61
effective length of query: 28
effective length of database: 15,937,692
effective search space: 446255376
effective search space used: 446255376
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 55 (25.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.