Search of human proteins with 22749221

Search of human proteins with 22749221

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|22749221 sprouty-related protein 1 with EVH-1 domain [Homo
sapiens]
         (444 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|22749221 sprouty-related protein 1 with EVH-1 domain [Homo sa...   922   0.0  
gi|189571669 sprouty-related protein with EVH-1 domain 2 isoform...   427   e-120
gi|189571671 sprouty-related protein with EVH-1 domain 2 isoform...   424   e-118
gi|110225353 sprouty-related, EVH1 domain containing 3 isoform a...   143   4e-34
gi|88853871 sprouty-related, EVH1 domain containing 3 isoform b ...   129   5e-30
gi|56549694 enabled homolog isoform a [Homo sapiens]                   75   9e-14
gi|39930375 enabled homolog isoform b [Homo sapiens]                   75   9e-14
gi|7706687 Enah/Vasp-like [Homo sapiens]                               69   9e-12
gi|27501452 sprouty homolog 3 [Homo sapiens]                           69   9e-12
gi|4507869 vasodilator-stimulated phosphoprotein [Homo sapiens]        65   2e-10
gi|40788001 sprouty homolog 1, antagonist of FGF signaling [Homo...    64   3e-10
gi|40538726 sprouty homolog 1, antagonist of FGF signaling [Homo...    64   3e-10
gi|5032115 sprouty 2 [Homo sapiens]                                    63   5e-10
gi|188595697 sprouty homolog 4 isoform 2 [Homo sapiens]                57   4e-08
gi|23308574 sprouty homolog 4 isoform 1 [Homo sapiens]                 57   4e-08
gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens]             38   0.021
gi|122891874 keratin associated protein 5-5 [Homo sapiens]             33   0.52 
gi|167234419 thyroid hormone receptor associated protein 3 [Homo...    33   0.52 
gi|148746195 trichohyalin [Homo sapiens]                               32   0.89 
gi|123702038 keratin associated protein 5-9 [Homo sapiens]             32   0.89 
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]     32   0.89 
gi|87299628 biorientation of chromosomes in cell division 1-like...    32   1.2  
gi|110611156 laminin, gamma 3 precursor [Homo sapiens]                 32   1.2  
gi|54400749 keratin associated protein 5-1 [Homo sapiens]              32   1.2  
gi|58530840 desmoplakin isoform I [Homo sapiens]                       31   2.0  
gi|150170670 piccolo isoform 2 [Homo sapiens]                          31   2.0  
gi|150378539 piccolo isoform 1 [Homo sapiens]                          31   2.0  
gi|253795481 plexin B3 isoform 2 [Homo sapiens]                        30   3.4  
gi|29336063 plexin B3 isoform 1 [Homo sapiens]                         30   3.4  
gi|14269578 metallothionein 4 [Homo sapiens]                           30   4.4  

>gi|22749221 sprouty-related protein 1 with EVH-1 domain [Homo
           sapiens]
          Length = 444

 Score =  922 bits (2384), Expect = 0.0
 Identities = 444/444 (100%), Positives = 444/444 (100%)

Query: 1   MSEETATSDNDNSYARVRAVVMTRDDSSGGWLPLGGSGLSSVTVFKVPHQEENGCADFFI 60
           MSEETATSDNDNSYARVRAVVMTRDDSSGGWLPLGGSGLSSVTVFKVPHQEENGCADFFI
Sbjct: 1   MSEETATSDNDNSYARVRAVVMTRDDSSGGWLPLGGSGLSSVTVFKVPHQEENGCADFFI 60

Query: 61  RGERLRDKMVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAI 120
           RGERLRDKMVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAI
Sbjct: 61  RGERLRDKMVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAI 120

Query: 121 EDISQGCPESKNEAEGADDLQANEEDSSSSLVKDHLFQQETVVTSEPYRSSNIRPSPFED 180
           EDISQGCPESKNEAEGADDLQANEEDSSSSLVKDHLFQQETVVTSEPYRSSNIRPSPFED
Sbjct: 121 EDISQGCPESKNEAEGADDLQANEEDSSSSLVKDHLFQQETVVTSEPYRSSNIRPSPFED 180

Query: 181 LNARRVYMQSQANQITFGQPGLDIQSRSMEYVQRQISKECGSLKSQNRVPLKSIRHVSFQ 240
           LNARRVYMQSQANQITFGQPGLDIQSRSMEYVQRQISKECGSLKSQNRVPLKSIRHVSFQ
Sbjct: 181 LNARRVYMQSQANQITFGQPGLDIQSRSMEYVQRQISKECGSLKSQNRVPLKSIRHVSFQ 240

Query: 241 DEDEIVRINPRDILIRRYADYRHPDMWKNDLERDDADSSIQFSKPDSKKSDYLYSCGDET 300
           DEDEIVRINPRDILIRRYADYRHPDMWKNDLERDDADSSIQFSKPDSKKSDYLYSCGDET
Sbjct: 241 DEDEIVRINPRDILIRRYADYRHPDMWKNDLERDDADSSIQFSKPDSKKSDYLYSCGDET 300

Query: 301 KLSSPKDSVVFKTQPSSLKIKKSKRRKEDGERSRCVYCQERFNHEENVRGKCQDAPDPIK 360
           KLSSPKDSVVFKTQPSSLKIKKSKRRKEDGERSRCVYCQERFNHEENVRGKCQDAPDPIK
Sbjct: 301 KLSSPKDSVVFKTQPSSLKIKKSKRRKEDGERSRCVYCQERFNHEENVRGKCQDAPDPIK 360

Query: 361 RCIYQVSCMLCAESMLYHCMSDSEGDFSDPCSCDTSDDKFCLRWLALVALSFIVPCMCCY 420
           RCIYQVSCMLCAESMLYHCMSDSEGDFSDPCSCDTSDDKFCLRWLALVALSFIVPCMCCY
Sbjct: 361 RCIYQVSCMLCAESMLYHCMSDSEGDFSDPCSCDTSDDKFCLRWLALVALSFIVPCMCCY 420

Query: 421 VPLRMCHRCGEACGCCGGKHKAAG 444
           VPLRMCHRCGEACGCCGGKHKAAG
Sbjct: 421 VPLRMCHRCGEACGCCGGKHKAAG 444


>gi|189571669 sprouty-related protein with EVH-1 domain 2 isoform a
           [Homo sapiens]
          Length = 418

 Score =  427 bits (1098), Expect = e-120
 Identities = 237/457 (51%), Positives = 289/457 (63%), Gaps = 54/457 (11%)

Query: 1   MSEETATSDNDNSYARVRAVVMTRDDSSGGWLPLGGSGLSSVTVFKVPHQEENGCADFFI 60
           M+EET   D+D+   RV+AVVMTRDDSSGGW P  G G+S V V KV H E NG + F I
Sbjct: 1   MTEETHP-DDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLI 59

Query: 61  RGERLRDKMVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAI 120
            GER +DK+VVLEC ++KDL+Y K  PTFHHWK+D++KFGLTFQSPADARAFDRG+R+AI
Sbjct: 60  HGERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAI 119

Query: 121 EDISQGCPESK----NEAE-GADDLQANEEDSSSSLVKDHLFQQETVVTSEPYRSSNIRP 175
           ED+ +G   S     NEAE G DD+     DSSS+  +    +Q T   S P    +   
Sbjct: 120 EDLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQKR--EQPTRTISSPTSCEH--- 174

Query: 176 SPFEDLNARRVYMQSQANQITFGQPGLDIQSRSMEYVQRQISKECGSLKSQNRVPLKSIR 235
                   RR+Y     +                       S           +P +  R
Sbjct: 175 --------RRIYTLGHLHD----------------------SYPTDHYHLDQPMP-RPYR 203

Query: 236 HVSFQDEDE-IVRINPRD-ILIRRYADYRH-PDMWKNDLERDDADSS-IQFSKPDSKKSD 291
            VSF D+DE IVRINPR+ I +  Y DYRH P   K     +DADSS ++F+K +  K D
Sbjct: 204 QVSFPDDDEEIVRINPREKIWMTGYEDYRHAPVRGKYPDPSEDADSSYVRFAKGEVPKHD 263

Query: 292 YLYSCGDETKLSSPKD-----SVVFKTQPSSLKIKKSKRRKEDGERSRCVYCQERFNHEE 346
           Y Y   D +     +D       V KTQPS     KS+RRKEDGERSRCVYC++ FNHEE
Sbjct: 264 YNYPYVDSSDFGLGEDPKGRGGSVIKTQPSR---GKSRRRKEDGERSRCVYCRDMFNHEE 320

Query: 347 NVRGKCQDAPDPIKRCIYQVSCMLCAESMLYHCMSDSEGDFSDPCSCDTSDDKFCLRWLA 406
           N RG CQDAPD ++ CI +VSCM CA+SMLYHCMSD EGD++DPCSCDTSD+KFCLRW+A
Sbjct: 321 NRRGHCQDAPDSVRTCIRRVSCMWCADSMLYHCMSDPEGDYTDPCSCDTSDEKFCLRWMA 380

Query: 407 LVALSFIVPCMCCYVPLRMCHRCGEACGCCGGKHKAA 443
           L+ALSF+ PCMCCY+PLR C+ CG  C CCGGKHKAA
Sbjct: 381 LIALSFLAPCMCCYLPLRACYHCGVMCRCCGGKHKAA 417


>gi|189571671 sprouty-related protein with EVH-1 domain 2 isoform b
           [Homo sapiens]
          Length = 415

 Score =  424 bits (1089), Expect = e-118
 Identities = 233/452 (51%), Positives = 285/452 (63%), Gaps = 53/452 (11%)

Query: 6   ATSDNDNSYARVRAVVMTRDDSSGGWLPLGGSGLSSVTVFKVPHQEENGCADFFIRGERL 65
           A+  +D+   RV+AVVMTRDDSSGGW P  G G+S V V KV H E NG + F I GER 
Sbjct: 2   ASPGSDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIHGERQ 61

Query: 66  RDKMVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAIEDISQ 125
           +DK+VVLEC ++KDL+Y K  PTFHHWK+D++KFGLTFQSPADARAFDRG+R+AIED+ +
Sbjct: 62  KDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIEDLIE 121

Query: 126 GCPESK----NEAE-GADDLQANEEDSSSSLVKDHLFQQETVVTSEPYRSSNIRPSPFED 180
           G   S     NEAE G DD+     DSSS+  +    +Q T   S P    +        
Sbjct: 122 GSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQKR--EQPTRTISSPTSCEH-------- 171

Query: 181 LNARRVYMQSQANQITFGQPGLDIQSRSMEYVQRQISKECGSLKSQNRVPLKSIRHVSFQ 240
              RR+Y     +                       S           +P +  R VSF 
Sbjct: 172 ---RRIYTLGHLHD----------------------SYPTDHYHLDQPMP-RPYRQVSFP 205

Query: 241 DEDE-IVRINPRD-ILIRRYADYRH-PDMWKNDLERDDADSS-IQFSKPDSKKSDYLYSC 296
           D+DE IVRINPR+ I +  Y DYRH P   K     +DADSS ++F+K +  K DY Y  
Sbjct: 206 DDDEEIVRINPREKIWMTGYEDYRHAPVRGKYPDPSEDADSSYVRFAKGEVPKHDYNYPY 265

Query: 297 GDETKLSSPKD-----SVVFKTQPSSLKIKKSKRRKEDGERSRCVYCQERFNHEENVRGK 351
            D +     +D       V KTQPS     KS+RRKEDGERSRCVYC++ FNHEEN RG 
Sbjct: 266 VDSSDFGLGEDPKGRGGSVIKTQPSR---GKSRRRKEDGERSRCVYCRDMFNHEENRRGH 322

Query: 352 CQDAPDPIKRCIYQVSCMLCAESMLYHCMSDSEGDFSDPCSCDTSDDKFCLRWLALVALS 411
           CQDAPD ++ CI +VSCM CA+SMLYHCMSD EGD++DPCSCDTSD+KFCLRW+AL+ALS
Sbjct: 323 CQDAPDSVRTCIRRVSCMWCADSMLYHCMSDPEGDYTDPCSCDTSDEKFCLRWMALIALS 382

Query: 412 FIVPCMCCYVPLRMCHRCGEACGCCGGKHKAA 443
           F+ PCMCCY+PLR C+ CG  C CCGGKHKAA
Sbjct: 383 FLAPCMCCYLPLRACYHCGVMCRCCGGKHKAA 414


>gi|110225353 sprouty-related, EVH1 domain containing 3 isoform a
           [Homo sapiens]
          Length = 410

 Score =  143 bits (360), Expect = 4e-34
 Identities = 66/132 (50%), Positives = 86/132 (65%), Gaps = 6/132 (4%)

Query: 315 PSSLKIKKSKRRKEDGERSRCVYCQERFNHEENVRG-KCQDAPDPIKRCIYQVSCMLCAE 373
           PSS   K S    E  E +RCV+C+  F    + RG +C +APDP +  + ++SC+ CAE
Sbjct: 280 PSSAPAKASP---EAEEAARCVHCRALFRRRADGRGGRCAEAPDPGRLLVRRLSCLWCAE 336

Query: 374 SMLYHCMSDSEGDFSDPCSCDTSDDKFCLRWLALVALSFIVPCMCCYVPLRMCHRCGEAC 433
           S+LYHC+SD+EGDFSDPC+C+    +   RW AL ALS  VPC+CCY PLR CH     C
Sbjct: 337 SLLYHCLSDAEGDFSDPCACEPGHPRPAARWAALAALSLAVPCLCCYAPLRACHWVAARC 396

Query: 434 GC--CGGKHKAA 443
           GC  CGG+H+ A
Sbjct: 397 GCAGCGGRHEEA 408



 Score =  129 bits (324), Expect = 5e-30
 Identities = 66/133 (49%), Positives = 82/133 (61%), Gaps = 3/133 (2%)

Query: 16  RVRAVVMTRDDSSGGWLPLGGSGLSSVTVFKVPHQEENGCA---DFFIRGERLRDKMVVL 72
           RVRAVVM RDDSSGGWLP+GG GLS V+V +V      G A    + I GERLRD+   L
Sbjct: 3   RVRAVVMARDDSSGGWLPVGGGGLSQVSVCRVRGARPEGGARQGHYVIHGERLRDQKTTL 62

Query: 73  ECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAIEDISQGCPESKN 132
           EC LK  L+YNKV P FHHW + D KFGLTFQSPA+A  F + +  A+  + +G     +
Sbjct: 63  ECTLKPGLVYNKVNPIFHHWSLGDCKFGLTFQSPAEADEFQKSLLAALAALGRGSLTPSS 122

Query: 133 EAEGADDLQANEE 145
            +  +   Q   E
Sbjct: 123 SSSSSSPSQDTAE 135


>gi|88853871 sprouty-related, EVH1 domain containing 3 isoform b
           [Homo sapiens]
          Length = 152

 Score =  129 bits (324), Expect = 5e-30
 Identities = 66/133 (49%), Positives = 82/133 (61%), Gaps = 3/133 (2%)

Query: 16  RVRAVVMTRDDSSGGWLPLGGSGLSSVTVFKVPHQEENGCA---DFFIRGERLRDKMVVL 72
           RVRAVVM RDDSSGGWLP+GG GLS V+V +V      G A    + I GERLRD+   L
Sbjct: 3   RVRAVVMARDDSSGGWLPVGGGGLSQVSVCRVRGARPEGGARQGHYVIHGERLRDQKTTL 62

Query: 73  ECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAIEDISQGCPESKN 132
           EC LK  L+YNKV P FHHW + D KFGLTFQSPA+A  F + +  A+  + +G     +
Sbjct: 63  ECTLKPGLVYNKVNPIFHHWSLGDCKFGLTFQSPAEADEFQKSLLAALAALGRGSLTPSS 122

Query: 133 EAEGADDLQANEE 145
            +  +   Q   E
Sbjct: 123 SSSSSSPSQDTAE 135


>gi|56549694 enabled homolog isoform a [Homo sapiens]
          Length = 591

 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 40/113 (35%), Positives = 60/113 (53%), Gaps = 6/113 (5%)

Query: 10  NDNSYARVRAVVMTRDDSSGGWLPLGGS-GLSSVTVFKVPHQEENGCADFFIRGERLRDK 68
           ++ S  + RA VM  DD++  W+P GGS G S V ++        G   F + G +++D 
Sbjct: 2   SEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIY-----HHTGNNTFRVVGRKIQDH 56

Query: 69  MVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAIE 121
            VV+ C + K L YN+ T TFH W+   + +GL F S  DA  F   +  A+E
Sbjct: 57  QVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALE 109


>gi|39930375 enabled homolog isoform b [Homo sapiens]
          Length = 570

 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 40/113 (35%), Positives = 60/113 (53%), Gaps = 6/113 (5%)

Query: 10  NDNSYARVRAVVMTRDDSSGGWLPLGGS-GLSSVTVFKVPHQEENGCADFFIRGERLRDK 68
           ++ S  + RA VM  DD++  W+P GGS G S V ++        G   F + G +++D 
Sbjct: 2   SEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIY-----HHTGNNTFRVVGRKIQDH 56

Query: 69  MVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAIE 121
            VV+ C + K L YN+ T TFH W+   + +GL F S  DA  F   +  A+E
Sbjct: 57  QVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALE 109


>gi|7706687 Enah/Vasp-like [Homo sapiens]
          Length = 418

 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 40/130 (30%), Positives = 66/130 (50%), Gaps = 9/130 (6%)

Query: 10  NDNSYARVRAVVMTRDDSSGGWLPL--GGSGLSSVTVFKVPHQEENGCADFFIRGERLRD 67
           ++ S  + RA VM  DD+S  W+P+  G  G S + ++            F + G +L+D
Sbjct: 4   SEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIY-----HNTASNTFRVVGVKLQD 58

Query: 68  KMVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRA--IEDISQ 125
           + VV+   + K L YN+ TPTFH W+   + +GL F S  +A  F   +  A  I +  +
Sbjct: 59  QQVVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNSQE 118

Query: 126 GCPESKNEAE 135
           G P S+ + +
Sbjct: 119 GGPSSQRQVQ 128


>gi|27501452 sprouty homolog 3 [Homo sapiens]
          Length = 288

 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 47/146 (32%), Positives = 70/146 (47%), Gaps = 23/146 (15%)

Query: 304 SPKDSVVFKTQPSS-LKIKKSKRRKEDGERSRCVYCQERFNHEENVRGKCQD--APDPI- 359
           SP    + +TQP + +  K     K + E+S     +  F  EE  R KC    A  P+ 
Sbjct: 106 SPSGQSIIRTQPGAGVHPKADGALKGEAEQSAGHPSEHLFICEECGRCKCVPCTAARPLP 165

Query: 360 ------KRCIYQV-------SCMLCAESMLYHCMSDSEGDFSD-PCSCDTSDDKFC-LRW 404
                 +RC+          +C+ C + + YHC +D E + +D PCSC  S    C +RW
Sbjct: 166 SCWLCNQRCLCSAESLLDYGTCLCCVKGLFYHCSTDDEDNCADEPCSCGPSS---CFVRW 222

Query: 405 LALVALSFIVPCMCCYVPLRMC-HRC 429
            A+  +S  +PC+CCY+P R C H C
Sbjct: 223 AAMSLISLFLPCLCCYLPTRGCLHLC 248


>gi|4507869 vasodilator-stimulated phosphoprotein [Homo sapiens]
          Length = 380

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 37/112 (33%), Positives = 59/112 (52%), Gaps = 4/112 (3%)

Query: 18  RAVVMTRDDSSGGWLPLGGSGLSSVTVFKVPHQEENGCADFFIRGERLR-DKMVVLECML 76
           RA VM  DD +  WLP  G+G  + +  ++ H        F + G +++ D+ VV+ C +
Sbjct: 10  RATVMLYDDGNKRWLP-AGTGPQAFSRVQIYHNPTAN--SFRVVGRKMQPDQQVVINCAI 66

Query: 77  KKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAIEDISQGCP 128
            + + YN+ TP FH W+   + +GL F S  DA  F  G+  A+E +  G P
Sbjct: 67  VRGVKYNQATPNFHQWRDARQVWGLNFGSKEDAAQFAAGMASALEALEGGGP 118


>gi|40788001 sprouty homolog 1, antagonist of FGF signaling [Homo
           sapiens]
          Length = 319

 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 49/141 (34%), Positives = 68/141 (48%), Gaps = 32/141 (22%)

Query: 312 KTQPSSLKIKKSKRR-KEDGERSRCVYCQERFNHEENVRGKCQD--APDPIKRCIY-QVS 367
           +TQP  L +   K   KED         Q +F  E+  + KC +  AP  +  C+     
Sbjct: 155 RTQPKQLIVDDLKGSLKED-------LTQHKFICEQCGKCKCGECTAPRTLPSCLACNRQ 207

Query: 368 CMLCAESML-------------YHCMSDSEGD-FSD-PCSCDTSDDKFCLRWLALVALSF 412
           C+  AESM+             YHC +D EGD +SD PCSC  S    C R+L + A+S 
Sbjct: 208 CLCSAESMVEYGTCMCLVKGIFYHCSNDDEGDSYSDNPCSC--SQSHCCSRYLCMGAMSL 265

Query: 413 IVPCMCCYVP----LRMCHRC 429
            +PC+ CY P    L++C RC
Sbjct: 266 FLPCLLCYPPAKGCLKLCRRC 286


>gi|40538726 sprouty homolog 1, antagonist of FGF signaling [Homo
           sapiens]
          Length = 319

 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 49/141 (34%), Positives = 68/141 (48%), Gaps = 32/141 (22%)

Query: 312 KTQPSSLKIKKSKRR-KEDGERSRCVYCQERFNHEENVRGKCQD--APDPIKRCIY-QVS 367
           +TQP  L +   K   KED         Q +F  E+  + KC +  AP  +  C+     
Sbjct: 155 RTQPKQLIVDDLKGSLKED-------LTQHKFICEQCGKCKCGECTAPRTLPSCLACNRQ 207

Query: 368 CMLCAESML-------------YHCMSDSEGD-FSD-PCSCDTSDDKFCLRWLALVALSF 412
           C+  AESM+             YHC +D EGD +SD PCSC  S    C R+L + A+S 
Sbjct: 208 CLCSAESMVEYGTCMCLVKGIFYHCSNDDEGDSYSDNPCSC--SQSHCCSRYLCMGAMSL 265

Query: 413 IVPCMCCYVP----LRMCHRC 429
            +PC+ CY P    L++C RC
Sbjct: 266 FLPCLLCYPPAKGCLKLCRRC 286


>gi|5032115 sprouty 2 [Homo sapiens]
          Length = 315

 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 25/68 (36%), Positives = 40/68 (58%), Gaps = 3/68 (4%)

Query: 367 SCMLCAESMLYHCMSDSEGDFSD-PCSCDTSDDKFCLRWLALVALSFIVPCMCCYVPLRM 425
           +C+ C + + YHC +D E + +D PCSC  S    C RW A+  +S  +PC+ CY+P + 
Sbjct: 217 TCVCCVKGLFYHCSNDDEDNCADNPCSC--SQSHCCTRWSAMGVMSLFLPCLWCYLPAKG 274

Query: 426 CHRCGEAC 433
           C +  + C
Sbjct: 275 CLKLCQGC 282


>gi|188595697 sprouty homolog 4 isoform 2 [Homo sapiens]
          Length = 299

 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 26/62 (41%), Positives = 37/62 (59%), Gaps = 4/62 (6%)

Query: 367 SCMLCAESMLYHCMS-DSEGDFSD-PCSCDTSDDKFCLRWLALVALSFIVPCMCCYVPLR 424
           +CM   + + YHC + D EG  +D PCSC  S+   C RW  + ALS ++PC+ CY+P  
Sbjct: 198 TCMCLVQGIFYHCTNEDDEGSCADHPCSCSRSN--CCARWSFMGALSVVLPCLLCYLPAT 255

Query: 425 MC 426
            C
Sbjct: 256 GC 257


>gi|23308574 sprouty homolog 4 isoform 1 [Homo sapiens]
          Length = 322

 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 26/62 (41%), Positives = 37/62 (59%), Gaps = 4/62 (6%)

Query: 367 SCMLCAESMLYHCMS-DSEGDFSD-PCSCDTSDDKFCLRWLALVALSFIVPCMCCYVPLR 424
           +CM   + + YHC + D EG  +D PCSC  S+   C RW  + ALS ++PC+ CY+P  
Sbjct: 221 TCMCLVQGIFYHCTNEDDEGSCADHPCSCSRSN--CCARWSFMGALSVVLPCLLCYLPAT 278

Query: 425 MC 426
            C
Sbjct: 279 GC 280


>gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens]
          Length = 502

 Score = 37.7 bits (86), Expect = 0.021
 Identities = 23/75 (30%), Positives = 39/75 (52%)

Query: 51  EENGCADFFIRGERLRDKMVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADAR 110
           ++N    +FIR   L+   ++ E  L   L+Y+  TP FH +  DD + GL F    +A+
Sbjct: 76  KDNPQKSYFIRLYGLQAGRLLWEQELYSQLVYSTPTPFFHTFAGDDCQAGLNFADEDEAQ 135

Query: 111 AFDRGIRRAIEDISQ 125
           AF   ++  I+  +Q
Sbjct: 136 AFRALVQEKIQKRNQ 150


>gi|122891874 keratin associated protein 5-5 [Homo sapiens]
          Length = 237

 Score = 33.1 bits (74), Expect = 0.52
 Identities = 13/26 (50%), Positives = 15/26 (57%), Gaps = 1/26 (3%)

Query: 417 MCCYVPLRMCHRCGE-ACGCCGGKHK 441
           MCC VP   C  CG+  CG CGG  +
Sbjct: 72  MCCCVPACSCSSCGKGGCGSCGGSKR 97


>gi|167234419 thyroid hormone receptor associated protein 3 [Homo
           sapiens]
          Length = 955

 Score = 33.1 bits (74), Expect = 0.52
 Identities = 44/213 (20%), Positives = 79/213 (37%), Gaps = 18/213 (8%)

Query: 140 LQANEEDSSSSLVKDHLFQQETVVTSEPYRSSNIRPSPFEDLNARRVYMQSQANQITFGQ 199
           L A E      LV  +  +QE     +  +S+  + SP E      V +     +  FG 
Sbjct: 586 LLAQERKLCRDLVHSNKKEQEFRSIFQHIQSAQSQRSPSELFAQHIVTIVHHVKEHHFGS 645

Query: 200 PGLDIQSRSMEYVQRQISKECGSLKSQNRV-------PLKSIRHVSFQDEDEIVRINPRD 252
            G+ +  R  +Y++R   +E    K    +       P    +H    DE +    +PR+
Sbjct: 646 SGMTLHERFTKYLKRGTEQEAAKNKKSPEIHRRIDISPSTFRKHGLAHDEMK----SPRE 701

Query: 253 ILIRRYADYR-HPDMWKNDLERDDADSSIQFSKPDSKKSDYLYSCGDETKLSSPKDSVVF 311
              +    Y+  P   + D+ER          +  S++S       D    S  ++    
Sbjct: 702 PGYKAEGKYKDDPVDLRLDIERRKKHKERDLKRGKSRES------VDSRDSSHSRERSAE 755

Query: 312 KTQPSSLKIKKSKRRKEDGERSRCVYCQERFNH 344
           KT+ +    KK K+ +   +RSR      + +H
Sbjct: 756 KTEKTHKGSKKQKKHRRARDRSRSSSSSSQSSH 788


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 32.3 bits (72), Expect = 0.89
 Identities = 53/244 (21%), Positives = 96/244 (39%), Gaps = 24/244 (9%)

Query: 123 ISQGCPESKNEAEGADDLQANEEDSSSSLVKDHLFQQETVVTSEPYRSSNIRPSPFEDLN 182
           ++Q C  +  +A G D+ +    D   SL++D   Q+E     EP R   +   P +   
Sbjct: 81  VAQACYYALGQATGLDEEKRARCDGKESLLQDRR-QEEDQRRFEP-RDRQLEEEPGQ--- 135

Query: 183 ARRVYMQSQANQITFGQPGLDIQSRSME----------YVQRQISKECGSLKSQNR--VP 230
            RR   Q Q  ++  G+   + Q R  +          + QRQ  +E    +++      
Sbjct: 136 RRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQS 195

Query: 231 LKSIRHVSFQDEDEIVRINPRDILIRRYADYRHPDMWKNDLERDDADSSIQFSKPDSKKS 290
            K      F DE+++ R   R++L  R          +   ER D     +  K   K+ 
Sbjct: 196 CKGHETEEFPDEEQLRR---RELLELRRKGREEKQQQRR--ERQDRVFQEEEEKEWRKRE 250

Query: 291 DYLYSCGDETKLSSPKDSVVFKTQPSSLKIKKSKRRKEDGERSRCVYCQERFNHEENVRG 350
             L    +E KL   +     + Q    +++K +R++   ER      Q+R   E+ +R 
Sbjct: 251 TVLRK--EEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRR 308

Query: 351 KCQD 354
           K ++
Sbjct: 309 KQEE 312


>gi|123702038 keratin associated protein 5-9 [Homo sapiens]
          Length = 169

 Score = 32.3 bits (72), Expect = 0.89
 Identities = 13/29 (44%), Positives = 15/29 (51%), Gaps = 1/29 (3%)

Query: 417 MCCYVPLRMCHRCGE-ACGCCGGKHKAAG 444
           +CC VP   C  CG+  CG CGG     G
Sbjct: 45  VCCCVPACSCSSCGKRGCGSCGGSKGGCG 73


>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
          Length = 809

 Score = 32.3 bits (72), Expect = 0.89
 Identities = 15/36 (41%), Positives = 22/36 (61%), Gaps = 2/36 (5%)

Query: 390 PCSCDTSDDKFCLRWLALVALSFIVPCMCCYVPLRM 425
           P S D+  D+  L WL LV L++     CC++PLR+
Sbjct: 207 PNSIDSYTDRLYLLWLLLVTLAY--NWNCCFIPLRL 240


>gi|87299628 biorientation of chromosomes in cell division 1-like
           [Homo sapiens]
          Length = 3051

 Score = 32.0 bits (71), Expect = 1.2
 Identities = 50/229 (21%), Positives = 87/229 (37%), Gaps = 40/229 (17%)

Query: 129 ESKNEAEGADDLQANEEDSSSSLVKDHLFQQETVVTSEPYRSSNIRPSPFEDLNARRVYM 188
           +S+N  E +   Q  EEDS  +L      ++E + +S+  +  + +  P +   ARR+  
Sbjct: 579 DSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKP--ARRLSE 636

Query: 189 QSQANQITFGQPGLDIQSRS-------MEYVQ---------RQISKE--CGSLKSQNRVP 230
                     +  L+ + +        ME VQ         RQ+ +   C     + +  
Sbjct: 637 SLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKST 696

Query: 231 LKSIRHVSFQDEDEIVRINPRDILIRRYADYRHPDMWKNDLERDDADSSIQFSKPDSKKS 290
           LK+ +H+  +D+ E   +     L+++          K   ER+   S  + S     K 
Sbjct: 697 LKNEKHLK-KDDSETPHLKS---LLKKEVKSS-----KEKPEREKTPSEDKLSVKHKYKG 747

Query: 291 DYLYSCGDETKLSS-----------PKDSVVFKTQPSSLKIKKSKRRKE 328
           D ++  GDET+L S            K S   K        +KSK R E
Sbjct: 748 DCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNE 796


>gi|110611156 laminin, gamma 3 precursor [Homo sapiens]
          Length = 1575

 Score = 32.0 bits (71), Expect = 1.2
 Identities = 18/67 (26%), Positives = 24/67 (35%), Gaps = 3/67 (4%)

Query: 330 GERSRCVYCQERFNHEENVRGKCQDAPDPIKRCIYQVS---CMLCAESMLYHCMSDSEGD 386
           G    C  CQ   N + N  G C        RC++  +   C  C E      ++    D
Sbjct: 802 GHPQPCHQCQCSGNVDPNAVGNCDPLSGHCLRCLHNTTGDHCEHCQEGFYGSALAPRPAD 861

Query: 387 FSDPCSC 393
              PCSC
Sbjct: 862 KCMPCSC 868


>gi|54400749 keratin associated protein 5-1 [Homo sapiens]
          Length = 278

 Score = 32.0 bits (71), Expect = 1.2
 Identities = 14/29 (48%), Positives = 15/29 (51%), Gaps = 1/29 (3%)

Query: 417 MCCYVPLRMCHRCGE-ACGCCGGKHKAAG 444
           MCC VP   C  CG+  CG CG    A G
Sbjct: 140 MCCCVPACSCSSCGKGGCGSCGCSKGACG 168


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score = 31.2 bits (69), Expect = 2.0
 Identities = 39/134 (29%), Positives = 62/134 (46%), Gaps = 16/134 (11%)

Query: 104  QSPADARAFDRGIRRAIEDISQGCPESKNEAEGADDLQANEEDSSSSLVKDHLFQQETV- 162
            +S   A   +   ++AIED S+   ESK E E    L  N       L K+HL  +E + 
Sbjct: 1673 ESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTEN-------LTKEHLMLEEELR 1725

Query: 163  -VTSEPYRSSNIRPSPFEDLNARRVYMQSQ---ANQITFGQPGL--DIQSRSMEYVQRQI 216
             +  E       R     D NA  + ++SQ   +N  T    GL  D+Q R  E ++++I
Sbjct: 1726 NLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQ-RERENLRQEI 1784

Query: 217  SK-ECGSLKSQNRV 229
             K +  +L++ NR+
Sbjct: 1785 EKFQKQALEASNRI 1798


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 31.2 bits (69), Expect = 2.0
 Identities = 21/73 (28%), Positives = 33/73 (45%), Gaps = 3/73 (4%)

Query: 268  KNDLERDDADSSIQFSKPDSKKSDYLYSCGDETKLSSPKDSVVFKTQPSSLKIKKSKRRK 327
            + D  + D+   I  SK   +KS+++    D T    P DSV   ++  +  + + KRR 
Sbjct: 1475 RKDTFKKDSQQDIPSSKDHKEKSEFV---DDITTRREPYDSVEESSESENSPVPQRKRRT 1531

Query: 328  EDGERSRCVYCQE 340
              G  S   Y QE
Sbjct: 1532 SVGSSSSDEYKQE 1544


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 31.2 bits (69), Expect = 2.0
 Identities = 21/73 (28%), Positives = 33/73 (45%), Gaps = 3/73 (4%)

Query: 268  KNDLERDDADSSIQFSKPDSKKSDYLYSCGDETKLSSPKDSVVFKTQPSSLKIKKSKRRK 327
            + D  + D+   I  SK   +KS+++    D T    P DSV   ++  +  + + KRR 
Sbjct: 1475 RKDTFKKDSQQDIPSSKDHKEKSEFV---DDITTRREPYDSVEESSESENSPVPQRKRRT 1531

Query: 328  EDGERSRCVYCQE 340
              G  S   Y QE
Sbjct: 1532 SVGSSSSDEYKQE 1544


>gi|253795481 plexin B3 isoform 2 [Homo sapiens]
          Length = 1932

 Score = 30.4 bits (67), Expect = 3.4
 Identities = 13/39 (33%), Positives = 18/39 (46%)

Query: 406 ALVALSFIVPCMCCYVPLRMCHRCGEACGCCGGKHKAAG 444
           A+ AL    PC  C   +  CH C ++  C  G+H   G
Sbjct: 646 AVQALEAAAPCRACVGSIWRCHWCPQSSHCVYGEHCPEG 684


>gi|29336063 plexin B3 isoform 1 [Homo sapiens]
          Length = 1909

 Score = 30.4 bits (67), Expect = 3.4
 Identities = 13/39 (33%), Positives = 18/39 (46%)

Query: 406 ALVALSFIVPCMCCYVPLRMCHRCGEACGCCGGKHKAAG 444
           A+ AL    PC  C   +  CH C ++  C  G+H   G
Sbjct: 623 AVQALEAAAPCRACVGSIWRCHWCPQSSHCVYGEHCPEG 661


>gi|14269578 metallothionein 4 [Homo sapiens]
          Length = 62

 Score = 30.0 bits (66), Expect = 4.4
 Identities = 19/65 (29%), Positives = 23/65 (35%), Gaps = 13/65 (20%)

Query: 379 CMSDSEGDFSDPCSCDTSDDKFCLRWLALVALSFIVPCMCCYVPLRMCHRCGEACGCCGG 438
           CMS       D C C T + K C +            C CC      C +C   C C GG
Sbjct: 8   CMSGGICMCGDNCKCTTCNCKTCRKSC----------CPCCPPG---CAKCARGCICKGG 54

Query: 439 KHKAA 443
             K +
Sbjct: 55  SDKCS 59


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.133    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,778,890
Number of Sequences: 37866
Number of extensions: 819723
Number of successful extensions: 2569
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 39
Number of HSP's that attempted gapping in prelim test: 2478
Number of HSP's gapped (non-prelim): 113
length of query: 444
length of database: 18,247,518
effective HSP length: 105
effective length of query: 339
effective length of database: 14,271,588
effective search space: 4838068332
effective search space used: 4838068332
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.