Search of human proteins with 22748703

Search of human proteins with 22748703

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|22748703 endoplasmic reticulum protein 27 kDa [Homo sapiens]
         (273 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|22748703 endoplasmic reticulum protein 27 kDa [Homo sapiens]       538   e-153
gi|20070125 prolyl 4-hydroxylase, beta subunit precursor [Homo s...   127   1e-29
gi|28372543 protein disulfide isomerase-like, testis expressed [...   112   3e-25
gi|94966757 protein disulfide isomerase A2 [Homo sapiens]             103   1e-22
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]           30   1.7  
gi|54112420 Cas-Br-M (murine) ecotropic retroviral transforming ...    30   2.3  
gi|13489095 sialoadhesin precursor [Homo sapiens]                      30   3.0  
gi|150378537 hypothetical protein LOC55184 [Homo sapiens]              30   3.0  
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo...    29   3.9  
gi|119964726 insulin-like growth factor 2 receptor precursor [Ho...    29   5.0  
gi|217330559 unc-51-like kinase 2 [Homo sapiens]                       29   5.0  
gi|217330557 unc-51-like kinase 2 [Homo sapiens]                       29   5.0  
gi|33598950 podocalyxin-like isoform 2 precursor [Homo sapiens]        28   6.6  
gi|66277202 podocalyxin-like isoform 1 precursor [Homo sapiens]        28   6.6  
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom...    28   6.6  

>gi|22748703 endoplasmic reticulum protein 27 kDa [Homo sapiens]
          Length = 273

 Score =  538 bits (1387), Expect = e-153
 Identities = 273/273 (100%), Positives = 273/273 (100%)

Query: 1   MEAAPSRFMFLLFLLTCELAAEVAAEVEKSSDGPGAAQEPTWLTDVPAAMEFIAATEVAV 60
           MEAAPSRFMFLLFLLTCELAAEVAAEVEKSSDGPGAAQEPTWLTDVPAAMEFIAATEVAV
Sbjct: 1   MEAAPSRFMFLLFLLTCELAAEVAAEVEKSSDGPGAAQEPTWLTDVPAAMEFIAATEVAV 60

Query: 61  IGFFQDLEIPAVPILHSMVQKFPGVSFGISTDSEVLTHYNITGNTICLFRLVDNEQLNLE 120
           IGFFQDLEIPAVPILHSMVQKFPGVSFGISTDSEVLTHYNITGNTICLFRLVDNEQLNLE
Sbjct: 61  IGFFQDLEIPAVPILHSMVQKFPGVSFGISTDSEVLTHYNITGNTICLFRLVDNEQLNLE 120

Query: 121 DEDIESIDATKLSRFIEINSLHMVTEYNPVTVIGLFNSVIQIHLLLIMNKASPEYEENMH 180
           DEDIESIDATKLSRFIEINSLHMVTEYNPVTVIGLFNSVIQIHLLLIMNKASPEYEENMH
Sbjct: 121 DEDIESIDATKLSRFIEINSLHMVTEYNPVTVIGLFNSVIQIHLLLIMNKASPEYEENMH 180

Query: 181 RYQKAAKLFQGKILFILVDSGMKENGKVISFFKLKESQLPALAIYQTLDDEWDTLPTAEV 240
           RYQKAAKLFQGKILFILVDSGMKENGKVISFFKLKESQLPALAIYQTLDDEWDTLPTAEV
Sbjct: 181 RYQKAAKLFQGKILFILVDSGMKENGKVISFFKLKESQLPALAIYQTLDDEWDTLPTAEV 240

Query: 241 SVEHVQNFCDGFLSGKLLKENRESEGKTPKVEL 273
           SVEHVQNFCDGFLSGKLLKENRESEGKTPKVEL
Sbjct: 241 SVEHVQNFCDGFLSGKLLKENRESEGKTPKVEL 273


>gi|20070125 prolyl 4-hydroxylase, beta subunit precursor [Homo
           sapiens]
          Length = 508

 Score =  127 bits (318), Expect = 1e-29
 Identities = 75/231 (32%), Positives = 125/231 (54%), Gaps = 11/231 (4%)

Query: 29  KSSDGPGAAQEPTWLTDVPAAMEFIAATEVAVIGFFQDLEIPAVPILHSMVQKFPGVSFG 88
           K   GP A    T L D  AA   + ++EVAVIGFF+D+E  +        +    + FG
Sbjct: 130 KKRTGPAA----TTLPDGAAAESLVESSEVAVIGFFKDVESDSAKQFLQAAEAIDDIPFG 185

Query: 89  ISTDSEVLTHYNITGNTICLFRLVDNEQLNLEDEDIESIDATKLSRFIEINSLHMVTEYN 148
           I+++S+V + Y +  + + LF+  D  + N E E    +    L  FI+ N L +V E+ 
Sbjct: 186 ITSNSDVFSKYQLDKDGVVLFKKFDEGRNNFEGE----VTKENLLDFIKHNQLPLVIEFT 241

Query: 149 PVTVIGLFNSVIQIHLLLIMNKASPEYEENMHRYQKAAKLFQGKILFILVDSGMKENGKV 208
             T   +F   I+ H+LL + K+  +Y+  +  ++ AA+ F+GKILFI +DS   +N ++
Sbjct: 242 EQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQRI 301

Query: 209 ISFFKLKESQLPALAIYQTLDDEWDTL--PTAEVSVEHVQNFCDGFLSGKL 257
           + FF LK+ + PA+ +  TL++E       + E++ E +  FC  FL GK+
Sbjct: 302 LEFFGLKKEECPAVRLI-TLEEEMTKYKPESEELTAERITEFCHRFLEGKI 351


>gi|28372543 protein disulfide isomerase-like, testis expressed
           [Homo sapiens]
          Length = 584

 Score =  112 bits (280), Expect = 3e-25
 Identities = 64/217 (29%), Positives = 116/217 (53%), Gaps = 6/217 (2%)

Query: 51  EFIAATEVAVIGFFQDLEIPAVPILHSMVQKFPGVSFGISTDSEVLTHYNITGNTICLFR 110
           EF+ +  + ++GFFQDLE     + + +++ FP ++FG+ T   V+  +++T +++ +F+
Sbjct: 167 EFVISRPLVIVGFFQDLEEEVAELFYDVIKDFPELTFGVITIGNVIGRFHVTLDSVLVFK 226

Query: 111 L--VDNEQLNLEDEDIESIDATKLSRFIEINSLHMVTEYNPVTVIGLFNSVIQIHLLLIM 168
              + N Q  + D    S +  +L+R I+ +    V EYN      +    I  H+LL +
Sbjct: 227 KGKIVNRQKLIND----STNKQELNRVIKQHLTDFVIEYNTENKDLISELHIMSHMLLFV 282

Query: 169 NKASPEYEENMHRYQKAAKLFQGKILFILVDSGMKENGKVISFFKLKESQLPALAIYQTL 228
           +K+S  Y   +  Y+ A+K FQ KILFILVD+    NG+V  +F++ E  +P++ I    
Sbjct: 283 SKSSESYGIIIQHYKLASKEFQNKILFILVDADEPRNGRVFKYFRVTEVDIPSVQILNLS 342

Query: 229 DDEWDTLPTAEVSVEHVQNFCDGFLSGKLLKENRESE 265
            D    +P+ +++ E ++ F   FLS    K     E
Sbjct: 343 SDARYKMPSDDITYESLKKFGRSFLSKNATKHQSSEE 379


>gi|94966757 protein disulfide isomerase A2 [Homo sapiens]
          Length = 525

 Score =  103 bits (258), Expect = 1e-22
 Identities = 68/238 (28%), Positives = 120/238 (50%), Gaps = 6/238 (2%)

Query: 21  AEVAAEVEKSSDGPGAAQEPTWLTDVPAAMEFIAATEVAVIGFFQDLEIPAVPILHSMVQ 80
           AE  AE  +   GP A +    L D  AA   I   ++ VIGFFQDL+   V    ++ Q
Sbjct: 140 AEGIAEWLRRRVGPSAMR----LEDEAAAQALIGGRDLVVIGFFQDLQDEDVATFLALAQ 195

Query: 81  KFPGVSFGISTDSEVLTHYNITGNTICLFRLVDNEQLNLEDEDIESIDATKLSRFIEINS 140
               ++FG++    +   + +T +T+ LF+  D  + +   ++   +D   LSRF+  +S
Sbjct: 196 DALDMTFGLTDRPRLFQQFGLTKDTVVLFKKFDEGRADFPVDEELGLDLGDLSRFLVTHS 255

Query: 141 LHMVTEYNPVTVIGLFNSVIQIHLLLIMNKASPEYEENMHRYQKAAKLFQGKILFILVDS 200
           + +VTE+N  T   +F + I  HLLL +N+    + E +  + +AA  F+G++LF++VD 
Sbjct: 256 MRLVTEFNSQTSAKIFAARILNHLLLFVNQTLAAHRELLAGFGEAAPRFRGQVLFVVVDV 315

Query: 201 GMKENGKVISFFKLKESQLPALAIYQ-TLDDEWDTLPTAEVSVEHVQNFCDGFLSGKL 257
              +N  V+ +F LK    P L +       ++  +    V+   +  FC   L+G++
Sbjct: 316 A-ADNEHVLQYFGLKAEAAPTLRLVNLETTKKYAPVDGGPVTAASITAFCHAVLNGQV 372


>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
          Length = 582

 Score = 30.4 bits (67), Expect = 1.7
 Identities = 36/158 (22%), Positives = 70/158 (44%), Gaps = 24/158 (15%)

Query: 68  EIPAVPILHSMVQKFPGVSFGISTDSEVLTHYN-ITGNTICLFRLVDNEQLNLEDEDIES 126
           +I  + + H+ +   P     +S+ S +   YN ++     L +    E+LNLE+ +I +
Sbjct: 262 QITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNIST 321

Query: 127 IDATKLSRFIEINSLHMVTEYNPVTVIGLFNSVIQIHLLLIMNKASPEYEENMHRYQKAA 186
           +  + LS  +++NSL             L  +  Q++ +   ++ S  Y  NM   +   
Sbjct: 322 LPESLLSSLVKLNSL------------TLARNCFQLYPVGGPSQFSTIYSLNMEHNR--- 366

Query: 187 KLFQGKILFILVDSGMKENGKVISFFKLKESQLPALAI 224
                KI F     G+    KV+S   +K++QL +L +
Sbjct: 367 ---INKIPF-----GIFSRAKVLSKLNMKDNQLTSLPL 396


>gi|54112420 Cas-Br-M (murine) ecotropic retroviral transforming
           sequence b [Homo sapiens]
          Length = 982

 Score = 30.0 bits (66), Expect = 2.3
 Identities = 19/51 (37%), Positives = 30/51 (58%), Gaps = 8/51 (15%)

Query: 163 HLLLIMNKASPEYEENMHRYQKAAKLFQGKILFILVDSGMKENGKVISFFK 213
           HL LI++K    Y++N    QK A+L + +   I +DS MK++ + I  FK
Sbjct: 84  HLRLILSK----YDDN----QKLAQLSENEYFKIYIDSLMKKSKRAIRLFK 126


>gi|13489095 sialoadhesin precursor [Homo sapiens]
          Length = 1709

 Score = 29.6 bits (65), Expect = 3.0
 Identities = 14/50 (28%), Positives = 26/50 (52%)

Query: 47   PAAMEFIAATEVAVIGFFQDLEIPAVPILHSMVQKFPGVSFGISTDSEVL 96
            PAA++ + A + AV+  F+D    ++ ++   V   P     +S D +VL
Sbjct: 1337 PAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVL 1386


>gi|150378537 hypothetical protein LOC55184 [Homo sapiens]
          Length = 752

 Score = 29.6 bits (65), Expect = 3.0
 Identities = 31/132 (23%), Positives = 56/132 (42%), Gaps = 29/132 (21%)

Query: 151 TVIGLFNSVIQIHLLLIMNKASPEY-------EENMHRYQKAAKLFQGKILF--ILVDSG 201
           T++ + +    +++   ++ + PE+       E N  +Y K   L  GKI    I V   
Sbjct: 30  TLLEMKSDTPDVNIYYTLDGSKPEFLKRIGYGENNTFKYIKPITLPDGKIQVKAIAVSKD 89

Query: 202 MKENGKVISFFKLKESQLPALAIYQTLDDEWDTLPTAEVSVEHV------QNFCDGFLSG 255
            +++G V   F +              D E   + + E +VE+V      Q F +GF+  
Sbjct: 90  CRQSGIVTKVFHV--------------DYEPPNIVSPEDNVENVLKDSSRQEFKNGFVGS 135

Query: 256 KLLKENRESEGK 267
           KL K+ + SE +
Sbjct: 136 KLKKKYKNSENQ 147


>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
           sapiens]
          Length = 606

 Score = 29.3 bits (64), Expect = 3.9
 Identities = 32/124 (25%), Positives = 53/124 (42%), Gaps = 6/124 (4%)

Query: 67  LEIPAVPILHSMVQKFPGVS-FGISTDSEVLTHYNITGNTICLFR-LVDNEQLNLEDEDI 124
           LEI   P+L  M    P  S +G++  S  +T+ N++      F+ LV    LNL    I
Sbjct: 230 LEIDYWPLLDMM----PANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPI 285

Query: 125 ESIDATKLSRFIEINSLHMVTEYNPVTVIGLFNSVIQIHLLLIMNKASPEYEENMHRYQK 184
            +I+A   S  I +  LH+V           F  +  + +L +        EEN+    +
Sbjct: 286 STIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPR 345

Query: 185 AAKL 188
           A ++
Sbjct: 346 ALEV 349


>gi|119964726 insulin-like growth factor 2 receptor precursor [Homo
           sapiens]
          Length = 2491

 Score = 28.9 bits (63), Expect = 5.0
 Identities = 18/67 (26%), Positives = 30/67 (44%), Gaps = 6/67 (8%)

Query: 39  EPTWLTDVPAAMEFIAATEVAVIGFFQDLEIPAVPILHSMVQKFPGVSFGISTDSEVLTH 98
           E  W+T+     +++ +   ++ G  QD+ I   P+  S      G S  IS   E L +
Sbjct: 309 EIEWITEYACHRDYLESKTCSLSGEQQDVSIDLTPLAQS------GGSSYISDGKEYLFY 362

Query: 99  YNITGNT 105
            N+ G T
Sbjct: 363 LNVCGET 369


>gi|217330559 unc-51-like kinase 2 [Homo sapiens]
          Length = 1036

 Score = 28.9 bits (63), Expect = 5.0
 Identities = 23/76 (30%), Positives = 39/76 (51%), Gaps = 3/76 (3%)

Query: 131  KLSRFIEINSLHMVTEYNPVTVIGL-FNSVIQIHLLLIMNKASPEYEENMHRYQKAAKLF 189
            KL+RF   +    + E N VT   L +N  +++     +++   + E+ ++RY KAA L 
Sbjct: 941  KLNRFFS-DKQRFIDEINSVTAEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLL 999

Query: 190  QGKILFILVDSGMKEN 205
            +G +  IL D    EN
Sbjct: 1000 EG-LSRILQDPADIEN 1014


>gi|217330557 unc-51-like kinase 2 [Homo sapiens]
          Length = 1036

 Score = 28.9 bits (63), Expect = 5.0
 Identities = 23/76 (30%), Positives = 39/76 (51%), Gaps = 3/76 (3%)

Query: 131  KLSRFIEINSLHMVTEYNPVTVIGL-FNSVIQIHLLLIMNKASPEYEENMHRYQKAAKLF 189
            KL+RF   +    + E N VT   L +N  +++     +++   + E+ ++RY KAA L 
Sbjct: 941  KLNRFFS-DKQRFIDEINSVTAEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLL 999

Query: 190  QGKILFILVDSGMKEN 205
            +G +  IL D    EN
Sbjct: 1000 EG-LSRILQDPADIEN 1014


>gi|33598950 podocalyxin-like isoform 2 precursor [Homo sapiens]
          Length = 526

 Score = 28.5 bits (62), Expect = 6.6
 Identities = 12/25 (48%), Positives = 17/25 (68%)

Query: 217 SQLPALAIYQTLDDEWDTLPTAEVS 241
           ++LPA  +Y+ L D+WD L  A VS
Sbjct: 385 TKLPAKDVYERLKDKWDELKEAGVS 409


>gi|66277202 podocalyxin-like isoform 1 precursor [Homo sapiens]
          Length = 558

 Score = 28.5 bits (62), Expect = 6.6
 Identities = 12/25 (48%), Positives = 17/25 (68%)

Query: 217 SQLPALAIYQTLDDEWDTLPTAEVS 241
           ++LPA  +Y+ L D+WD L  A VS
Sbjct: 417 TKLPAKDVYERLKDKWDELKEAGVS 441


>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
           sapiens]
          Length = 592

 Score = 28.5 bits (62), Expect = 6.6
 Identities = 29/113 (25%), Positives = 43/113 (38%), Gaps = 4/113 (3%)

Query: 67  LEIPAVPILHSMVQKFPGVSFGISTDSEVLTHYNITGNTICLFRLVDNEQ-LNLEDEDIE 125
           LEI   P+L  +     G   G++  S  +TH NIT       R   +   LNL    I 
Sbjct: 227 LEIDNWPLLEEVAA---GSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPIS 283

Query: 126 SIDATKLSRFIEINSLHMVTEYNPVTVIGLFNSVIQIHLLLIMNKASPEYEEN 178
           ++        + +  LH+      V     F  + QI LL + N      EE+
Sbjct: 284 TVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEES 336


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.383 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,673,119
Number of Sequences: 37866
Number of extensions: 388273
Number of successful extensions: 848
Number of sequences better than 10.0: 15
Number of HSP's better than 10.0 without gapping: 7
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 835
Number of HSP's gapped (non-prelim): 18
length of query: 273
length of database: 18,247,518
effective HSP length: 101
effective length of query: 172
effective length of database: 14,423,052
effective search space: 2480764944
effective search space used: 2480764944
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.