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Search of human proteins with 226958575
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|226958575 RAS protein activator like 2 isoform 2 [Homo
sapiens]
(1280 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens] 2536 0.0
gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens] 2220 0.0
gi|94967023 disabled homolog 2 interacting protein isoform 1 [Ho... 1184 0.0
gi|41281683 disabled homolog 2 interacting protein isoform 2 [Ho... 1171 0.0
gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapi... 1016 0.0
gi|130502162 RAS protein activator like 3 [Homo sapiens] 437 e-122
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 178 3e-44
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 178 3e-44
gi|239743309 PREDICTED: similar to calcium-promoted Ras inactiva... 132 2e-30
gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva... 132 2e-30
gi|239508992 PREDICTED: similar to calcium-promoted Ras inactiva... 132 2e-30
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva... 132 2e-30
gi|38201692 RAS p21 protein activator 3 [Homo sapiens] 132 2e-30
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens] 132 3e-30
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens] 132 3e-30
gi|12545408 RAS p21 protein activator 2 [Homo sapiens] 113 1e-24
gi|4759026 RAS protein activator like 1 [Homo sapiens] 110 7e-24
gi|4557793 neurofibromin isoform 2 [Homo sapiens] 108 3e-23
gi|109826564 neurofibromin isoform 1 [Homo sapiens] 103 8e-22
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 61 6e-09
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 59 4e-08
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 55 3e-07
gi|156104908 myosin heavy chain 6 [Homo sapiens] 55 3e-07
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 55 4e-07
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 55 6e-07
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 54 7e-07
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 54 7e-07
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 54 7e-07
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 54 7e-07
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 54 1e-06
>gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens]
Length = 1280
Score = 2536 bits (6574), Expect = 0.0
Identities = 1280/1280 (100%), Positives = 1280/1280 (100%)
Query: 1 MELSPSSGGAAEALSWPEMFPALESDSPLPPEDLDAVVPVSGAVAGGMLDRILLESVCQQ 60
MELSPSSGGAAEALSWPEMFPALESDSPLPPEDLDAVVPVSGAVAGGMLDRILLESVCQQ
Sbjct: 1 MELSPSSGGAAEALSWPEMFPALESDSPLPPEDLDAVVPVSGAVAGGMLDRILLESVCQQ 60
Query: 61 QSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQEQQ 120
QSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQEQQ
Sbjct: 61 QSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQEQQ 120
Query: 121 TDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAERSPRRRSISGTSTSEKPNSMDTA 180
TDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAERSPRRRSISGTSTSEKPNSMDTA
Sbjct: 121 TDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAERSPRRRSISGTSTSEKPNSMDTA 180
Query: 181 NTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHES 240
NTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHES
Sbjct: 181 NTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHES 240
Query: 241 LLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMEN 300
LLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMEN
Sbjct: 241 LLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMEN 300
Query: 301 LRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFW 360
LRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFW
Sbjct: 301 LRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFW 360
Query: 361 GEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTP 420
GEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTP
Sbjct: 361 GEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTP 420
Query: 421 TPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELA 480
TPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELA
Sbjct: 421 TPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELA 480
Query: 481 CALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHD 540
CALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHD
Sbjct: 481 CALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHD 540
Query: 541 ALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEV 600
ALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEV
Sbjct: 541 ALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEV 600
Query: 601 FASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK 660
FASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK
Sbjct: 601 FASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK 660
Query: 661 VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRE 720
VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRE
Sbjct: 661 VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRE 720
Query: 721 LSVLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVS 780
LSVLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVS
Sbjct: 721 LSVLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVS 780
Query: 781 GSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERES 840
GSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERES
Sbjct: 781 GSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERES 840
Query: 841 SLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSA 900
SLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSA
Sbjct: 841 SLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSA 900
Query: 901 PQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSE 960
PQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSE
Sbjct: 901 PQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSE 960
Query: 961 DFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLG 1020
DFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLG
Sbjct: 961 DFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLG 1020
Query: 1021 ARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQ 1080
ARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQ
Sbjct: 1021 ARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQ 1080
Query: 1081 QTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKER 1140
QTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKER
Sbjct: 1081 QTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKER 1140
Query: 1141 LRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMA 1200
LRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMA
Sbjct: 1141 LRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMA 1200
Query: 1201 VEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGIS 1260
VEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGIS
Sbjct: 1201 VEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGIS 1260
Query: 1261 PTNPTKLSITENGEFKNSSC 1280
PTNPTKLSITENGEFKNSSC
Sbjct: 1261 PTNPTKLSITENGEFKNSSC 1280
>gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]
Length = 1139
Score = 2220 bits (5752), Expect = 0.0
Identities = 1128/1135 (99%), Positives = 1128/1135 (99%), Gaps = 7/1135 (0%)
Query: 153 EVPAERSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNT 212
EVPAERSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNT
Sbjct: 5 EVPAERSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNT 64
Query: 213 SFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQD 272
SFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQD
Sbjct: 65 SFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQD 124
Query: 273 FCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPK 332
FCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPK
Sbjct: 125 FCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPK 184
Query: 333 KKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKN 392
KKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKN
Sbjct: 185 KKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKN 244
Query: 393 NYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEF 452
NYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEF
Sbjct: 245 NYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEF 304
Query: 453 AEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHD 512
AEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHD
Sbjct: 305 AEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHD 364
Query: 513 VLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQ 572
VLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQ
Sbjct: 365 VLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQ 424
Query: 573 SNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCP 632
SNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCP
Sbjct: 425 SNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCP 484
Query: 633 AIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGM 692
AIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGM
Sbjct: 485 AIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGM 544
Query: 693 KRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDK-------ATVAKLGP 745
KRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDK ATVAKLGP
Sbjct: 545 KRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKLGP 604
Query: 746 LPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSP 805
LPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSP
Sbjct: 605 LPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSP 664
Query: 806 SQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHAS 865
SQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHAS
Sbjct: 665 SQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHAS 724
Query: 866 VMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNP 925
VMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNP
Sbjct: 725 VMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNP 784
Query: 926 VYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDF 985
VYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDF
Sbjct: 785 VYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDF 844
Query: 986 SRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVS 1045
SRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVS
Sbjct: 845 SRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVS 904
Query: 1046 AALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVL 1105
AALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVL
Sbjct: 905 AALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVL 964
Query: 1106 NNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKL 1165
NNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKL
Sbjct: 965 NNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKL 1024
Query: 1166 LLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDA 1225
LLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDA
Sbjct: 1025 LLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDA 1084
Query: 1226 QEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC 1280
QEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC
Sbjct: 1085 QEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC 1139
>gi|94967023 disabled homolog 2 interacting protein isoform 1 [Homo
sapiens]
Length = 1132
Score = 1184 bits (3064), Expect = 0.0
Identities = 655/1147 (57%), Positives = 827/1147 (72%), Gaps = 81/1147 (7%)
Query: 153 EVPAERSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNT 212
E P ER RRS+ G S SEK SM+ + +PF+V GF S+RLKGSIKRTKSQ KLDRN
Sbjct: 14 ESPQERPGSRRSLPG-SLSEKSPSMEPSAATPFRVTGFLSRRLKGSIKRTKSQPKLDRNH 72
Query: 213 SFR--LPSLRST------DDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPL 264
SFR LP RS ++RS +P+LKESRSHESLLSP S VE LDL E V +KP+
Sbjct: 73 SFRHILPGFRSAAAAAADNERSHLMPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPV 132
Query: 265 HSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWII 324
HSSILGQD+CFEVT SGSKCFSC SA+ERDKWMENLRR V PNKDN RR E++L+LW+I
Sbjct: 133 HSSILGQDYCFEVTTSSGSKCFSCRSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVI 192
Query: 325 EAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVE 384
EAKDL KKKY CELCLDD L+ARTT K K DN+FWGEHFEF +LPPL ++TVH+Y++ +
Sbjct: 193 EAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETD 252
Query: 385 KKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITIL 444
KKKKK++N+Y+GLV++P ASV GRQFVEKWYPV TP P GK GP IRIK+R+QTITIL
Sbjct: 253 KKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITIL 312
Query: 445 PMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSE 504
PME YKEFAE +T++Y LC+ LEP++S + KEE+A ALVHILQSTG+ KDFLTDL+MSE
Sbjct: 313 PMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSE 372
Query: 505 VDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCS 564
VDRCG+++ LIFRENT+ATK+IEEYLKLVGQ+YL DALGEFIKALYESDENCEVDPSKCS
Sbjct: 373 VDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCS 432
Query: 565 SSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISAS 624
+++L +HQ NLKMCCELAFCKIINSYCVFPRELKEVFASW+Q+C +RG+ DISERLISAS
Sbjct: 433 AADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISERLISAS 492
Query: 625 LFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDF 684
LFLRFLCPAIMSPSLFNL+QEYPDDRT+RTLTLIAKV QNLANFAKFG+KEEYM+FMN F
Sbjct: 493 LFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQF 552
Query: 685 LEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLG 744
LEHEW M+RFLLEISNP+T+SNT GF+GYIDLGRELS LHSLLWE VSQL+++ V+KLG
Sbjct: 553 LEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLG 612
Query: 745 PLPRVLADITKSLTNPTPIQQQLRRFTEHNSSP-NVSGSLSSGLQKIFEDPTDS---DLH 800
PLPR+L D+ +L+ TP QL + S+P + S S+S+GLQK+ + S D
Sbjct: 613 PLPRILRDVHTALS--TPGSGQLPGTNDLASTPGSGSSSISAGLQKMVIENDLSGLIDFT 670
Query: 801 KLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPN-GRSVSLMDLQDTHA- 858
+L SP+ +N D +F ++ VQ + ++S +YSE +E + + N G+S+S++DLQD
Sbjct: 671 RLPSPTPENKDLFFVTRS-SGVQPSPARSSSYSEANEPDLQMANGGKSLSMVDLQDARTL 729
Query: 859 ----------------AQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQ 902
Q A ++ P R T +++ +A++++ +T +TP ++
Sbjct: 730 DGEAGSPAGPDVLPTDGQAAAAQLVAGWPARAT--PVNLAGLATVRRAGQTPTTPGTS-- 785
Query: 903 VRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDF 962
A +P L PLSFQNPVY + +P P+ DS E S+ S S SNSE+
Sbjct: 786 -----EGAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLS--SHSNSEEL 838
Query: 963 KLS---GPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQ--- 1016
+ G +++ E+ +R E R+ ++ ++ +PRQNS G R++DQ
Sbjct: 839 AAAAKLGSFSTAAEELARR--PGELARRQMSLTEKGGQPTVPRQNSAGPQ--RRIDQPPP 894
Query: 1017 ----GGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSR-ESPV 1071
R + PP+L + S ++ SA+ + V +R RQQSSSS+ +SP
Sbjct: 895 PPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASAS--PDWVGPSTRLRQQSSSSKGDSPE 952
Query: 1072 PKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLN-NGQYEEDV--------EETEQNLD 1122
K RA+ +Q SPV + + ++RTAAW+L N Q ED + ++ D
Sbjct: 953 LKPRAVHKQG----PSPV---SPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKD 1005
Query: 1123 EAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRR 1182
E AEK ++ L+++LR+S+++LEEYE QE+ QKL+LEY+ARLE+ EERLRR
Sbjct: 1006 ELSQAEK---DLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRR 1062
Query: 1183 QQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMS 1242
QQE+KD QMK IISRLM+VEEELKKDHAEMQA +D+KQKIIDAQEKRI SLD+AN RLMS
Sbjct: 1063 QQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMS 1122
Query: 1243 ALTQVKE 1249
ALTQ+KE
Sbjct: 1123 ALTQLKE 1129
>gi|41281683 disabled homolog 2 interacting protein isoform 2 [Homo
sapiens]
Length = 1065
Score = 1171 bits (3030), Expect = 0.0
Identities = 636/1093 (58%), Positives = 801/1093 (73%), Gaps = 72/1093 (6%)
Query: 229 LPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSC 288
+P+LKESRSHESLLSP S VE LDL E V +KP+HSSILGQD+CFEVT SGSKCFSC
Sbjct: 1 MPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSC 60
Query: 289 NSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFAR 348
SA+ERDKWMENLRR V PNKDN RR E++L+LW+IEAKDL KKKY CELCLDD L+AR
Sbjct: 61 RSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYAR 120
Query: 349 TTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGR 408
TT K K DN+FWGEHFEF +LPPL ++TVH+Y++ +KKKKK++N+Y+GLV++P ASV GR
Sbjct: 121 TTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGR 180
Query: 409 QFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLE 468
QFVEKWYPV TP P GK GP IRIK+R+QTITILPME YKEFAE +T++Y LC+ LE
Sbjct: 181 QFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALE 240
Query: 469 PVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEE 528
P++S + KEE+A ALVHILQSTG+ KDFLTDL+MSEVDRCG+++ LIFRENT+ATK+IEE
Sbjct: 241 PILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEE 300
Query: 529 YLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIIN 588
YLKLVGQ+YL DALGEFIKALYESDENCEVDPSKCS+++L +HQ NLKMCCELAFCKIIN
Sbjct: 301 YLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIIN 360
Query: 589 SYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPD 648
SYCVFPRELKEVFASW+Q+C +RG+ DISERLISASLFLRFLCPAIMSPSLFNL+QEYPD
Sbjct: 361 SYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPD 420
Query: 649 DRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNT 708
DRT+RTLTLIAKV QNLANFAKFG+KEEYM+FMN FLEHEW M+RFLLEISNP+T+SNT
Sbjct: 421 DRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNT 480
Query: 709 PGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSLTNPTPIQQQLR 768
GF+GYIDLGRELS LHSLLWE VSQL+++ V+KLGPLPR+L D+ +L+ TP QL
Sbjct: 481 AGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALS--TPGSGQLP 538
Query: 769 RFTEHNSSP-NVSGSLSSGLQKIFEDPTDS---DLHKLKSPSQDNTDSYFRGKTLLLVQQ 824
+ S+P + S S+S+GLQK+ + S D +L SP+ +N D +F ++ VQ
Sbjct: 539 GTNDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTPENKDLFFVTRS-SGVQP 597
Query: 825 ASSQSMTYSEKDERESSLPN-GRSVSLMDLQDTHA-----------------AQVEHASV 866
+ ++S +YSE +E + + N G+S+S++DLQD Q A +
Sbjct: 598 SPARSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQL 657
Query: 867 MLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPV 926
+ P R T +++ +A++++ +T +TP ++ A +P L PLSFQNPV
Sbjct: 658 VAGWPARAT--PVNLAGLATVRRAGQTPTTPGTS-------EGAPGRPQLLAPLSFQNPV 708
Query: 927 YHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLS---GPSNSSMEDFTKRSTQSE 983
Y + +P P+ DS E S+ S S SNSE+ + G +++ E+ +R E
Sbjct: 709 YQMAAGLPLSPRGLGDSGSEGHSSLS--SHSNSEELAAAAKLGSFSTAAEELARR--PGE 764
Query: 984 DFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQ-------GGLGARAKAPPSLPHSASLR 1036
R+ ++ ++ +PRQNS G R++DQ R + PP+L +
Sbjct: 765 LARRQMSLTEKGGQPTVPRQNSAGPQ--RRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYP 822
Query: 1037 STGSMSVVSAALVAEPVQNGSRSRQQSSSSR-ESPVPKVRAIQRQQTQQVQSPVDSATMS 1095
S ++ SA+ + V +R RQQSSSS+ +SP K RA+ +Q SPV + +
Sbjct: 823 RPSSGTLASAS--PDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQG----PSPV---SPN 873
Query: 1096 PVERTAAWVLN-NGQYEEDV--------EETEQNLDEAKHAEKYEQEITKLKERLRVSSR 1146
++RTAAW+L N Q ED + ++ DE AEK ++ L+++LR+S++
Sbjct: 874 ALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQAEK---DLAVLQDKLRISTK 930
Query: 1147 RLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELK 1206
+LEEYE QE+ QKL+LEY+ARLE+ EERLRRQQE+KD QMK IISRLM+VEEELK
Sbjct: 931 KLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLMSVEEELK 990
Query: 1207 KDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTK 1266
KDHAEMQA +D+KQKIIDAQEKRI SLD+AN RLMSALTQ+KERYSMQ RNGISPTNPTK
Sbjct: 991 KDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKERYSMQARNGISPTNPTK 1050
Query: 1267 LSITENGEFKNSS 1279
L ITENGEF+NSS
Sbjct: 1051 LQITENGEFRNSS 1063
>gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapiens]
Length = 1343
Score = 1016 bits (2627), Expect = 0.0
Identities = 617/1370 (45%), Positives = 838/1370 (61%), Gaps = 197/1370 (14%)
Query: 62 SWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQEQQT 121
S+ DV+GP HR SPY + W ++CI++ +QL++L++++ P+ +++++
Sbjct: 17 SYAPFRDVRGPSMHRTQYVHSPY-DRPGWNPRFCIISGNQLLMLDEDEIHPLLI-RDRRS 74
Query: 122 DSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAERSPRRRSISGTSTSEKPNSMDTAN 181
+S++ + LRRTVSVP EG+ P G + + R R+S+ G K SM+ A
Sbjct: 75 ESSRNKLLRRTVSVPVEGR-----PHGEHEYHLGRSR---RKSVPGG----KQYSMEGAP 122
Query: 182 TSPFKVP-GFFSKRLKGSIKRTKSQSKLDRNTSFR--LPSLRSTD-DRSRGLPKLKESRS 237
+PF+ GF S+RLK SIKRTKSQ KLDR +SFR LP RS D DR+R + KES S
Sbjct: 123 AAPFRPSQGFLSRRLKSSIKRTKSQPKLDRTSSFRQILPRFRSADHDRARLMQSFKESHS 182
Query: 238 HESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKW 297
HESLLSP S E L+L E +KP+HSSILGQ+FCFEVT SG+KCF+C SA+ERDKW
Sbjct: 183 HESLLSPSSAAEALELNLDEDSIIKPVHSSILGQEFCFEVTTSSGTKCFACRSAAERDKW 242
Query: 298 MENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKA-- 355
+ENL+R V+PNKDN RR +NVL+LWIIEA++L PKK+Y+CELCLDD L+ARTTSK ++
Sbjct: 243 IENLQRAVKPNKDNSRRVDNVLKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSAS 302
Query: 356 -DNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKW 414
D +FWGEHFEF +LP + ++ +H+Y+D +KK+KKDK YVGLV +P A++ GR F E+W
Sbjct: 303 GDTVFWGEHFEFNNLPAVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQW 362
Query: 415 YPVSTPTPN--------------------KGKTGGPSIRIKSRFQTITILPMEQYKEFAE 454
YPV+ PT + KGK G P++R+K+R+QT++ILPME YKEFAE
Sbjct: 363 YPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAE 422
Query: 455 FVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVL 514
+VT++Y MLC+VLEP ++V+ KEE+A ALVHILQSTG+AKDFL+D+ MSEVDR E + L
Sbjct: 423 YVTNHYRMLCAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHL 482
Query: 515 IFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSN 574
IFRENT+ATK+IEEY++L+GQ+YL DA+GEFI+ALYES+ENCEVDP KC++S L +HQ+N
Sbjct: 483 IFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIKCTASSLAEHQAN 542
Query: 575 LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAI 634
L+MCCELA CK++NS+CVFPRELKEVFASW+ +C RG++DI++RLISASLFLRFLCPAI
Sbjct: 543 LRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAERGREDIADRLISASLFLRFLCPAI 602
Query: 635 MSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKR 694
MSPSLF LMQEYPD++TSRTLTLIAKVIQNLANF+KF +KE+++ FMN+FLE EWG M++
Sbjct: 603 MSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGSMQQ 662
Query: 695 FLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLGPLPRVLADIT 754
FL EISN DT++N+ F+GYIDLGRELS LH+LLWEV+ QL K + KLGPLPR+L DI+
Sbjct: 663 FLYEISNLDTLTNSSSFEGYIDLGRELSTLHALLWEVLPQLSKEALLKLGPLPRLLNDIS 722
Query: 755 KSLTNPTPIQQQLRRFTEH-----------------------NSSPNVSGSLSSGLQKIF 791
+L NP IQ+Q R +E NSS ++ ++ GL
Sbjct: 723 TALRNPN-IQRQPSRQSERPRPQPVVLRGPSAEMQGYMMRDLNSSIDLQSFMARGLN--- 778
Query: 792 EDPTDSDLHKLKSPSQDN--TDSYFRGKTLLLVQQ----ASSQSMTYSEKD---ERESSL 842
+ D+ +L SP+++ GK L V + SS + S D + L
Sbjct: 779 ---SSMDMARLPSPTKEKPPPPPPGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQKML 835
Query: 843 PNGRSVSLMDLQ-DTHAAQVEHASV--MLDVPIRLTGSQLSITQVASIKQL---RETQST 896
+SVS++DLQ D ++ +SV + V L SQ S+T ++ R +Q +
Sbjct: 836 SVNKSVSMLDLQGDGPGGRLNSSSVSNLAAVGDLLHSSQASLTAALGLRPAPAGRLSQGS 895
Query: 897 PQSAPQVRRPLHPALNQPGGLQ------PLSFQNPVYHLNNPIPAMPKASID-------- 942
S L G+ PLSFQNP++H+ P P
Sbjct: 896 GSSITAAGMRLSQMGVTTDGVPAQQLRIPLSFQNPLFHMAADGPGPPGGHGGGGGHGPPS 955
Query: 943 ---------------------------SSLENLSTASSR--------SQSNSEDFKLSGP 967
S E+LS+ + S S S++F GP
Sbjct: 956 SHHHHHHHHHHRGGEPPGDTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDEF---GP 1012
Query: 968 SNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPP 1027
S + DFT+R +D + +H + I + R +G GG G PP
Sbjct: 1013 SGT---DFTRRQLSLQD-NLQHMLSPPQITIGPQRPAPSGPGGGSGGGSGGGG--GGQPP 1066
Query: 1028 SLPHSASLRSTGSM------SVVSAALVAEPVQNGSRSRQQSSSSRES------------ 1069
L S + T S S + EP +R RQQS S S
Sbjct: 1067 PLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSYGPARPRQQSLSKEGSIGGSGGSGGGGG 1126
Query: 1070 --PVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVE------------ 1115
P + Q QT +P TM ERT AWV N D+E
Sbjct: 1127 GGLKPSITK-QHSQTPSTLNP----TMPASERTVAWVSNMPHLSADIESAHIEREEYKLK 1181
Query: 1116 ETEQNLDEAK--HAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARL 1173
E +++DE++ ++YE+EI LKERL +S+R+LEEYERRLL QE+Q K+L++Y+ARL
Sbjct: 1182 EYSKSMDESRLDRVKEYEEEIHSLKERLHMSNRKLEEYERRLLSQEEQTSKILMQYQARL 1241
Query: 1174 EDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEM-QAVIDAKQKIIDAQEKRIVS 1232
E SE+RLR+QQ EKDSQ+KSII RLM VEEEL++DH M + + + K++++DAQE+++
Sbjct: 1242 EQSEKRLRQQQAEKDSQIKSIIGRLMLVEEELRRDHPAMAEPLPEPKKRLLDAQERQLPP 1301
Query: 1233 LDSANTRLMSALTQVKERYSMQVRNGI---SPTNPTKLSITENGEFKNSS 1279
L N R+ A NG+ +P P +L ITENGEF+N++
Sbjct: 1302 LGPTNPRVTLA----------PPWNGLAPPAPPPPPRLQITENGEFRNTA 1341
>gi|130502162 RAS protein activator like 3 [Homo sapiens]
Length = 1011
Score = 437 bits (1123), Expect = e-122
Identities = 267/658 (40%), Positives = 373/658 (56%), Gaps = 47/658 (7%)
Query: 157 ERSPRRRSISGTSTSEKPNSMDTAN-TSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFR 215
E PRR + G+++SE + N P ++PG G + + L R +
Sbjct: 154 EEGPRRPRV-GSASSEGSIHVAMGNFRDPDRMPGKTEPETAGPNQVHNVRGLLKRLKEKK 212
Query: 216 LPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCF 275
L D G P SR ESL +T+ LDLG V + PLH S+LG+ CF
Sbjct: 213 KARLEPRD----GPPSALGSR--ESL----ATLSELDLGAERDVRIWPLHPSLLGEPHCF 262
Query: 276 EVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDL------ 329
+VT+ GS+CFSC SA+ERD+W+E+LRR QP +DN R E L +W+ EAK L
Sbjct: 263 QVTWTGGSRCFSCRSAAERDRWIEDLRRQFQPTQDNVEREETWLSVWVHEAKGLPRAAAG 322
Query: 330 APKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKK 389
AP + EL LD L ART + +FW E F F +LPP +++ + +
Sbjct: 323 APGVR--AELWLDGALLARTAPRAGPGQLFWAERFHFEALPPARRLSLRL------RGLG 374
Query: 390 DKNNYVGLVNI-------PTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTIT 442
+ +G V + P A G +E+W+P+ G G ++R + R + +
Sbjct: 375 PGSAVLGRVALALEELDAPRAPAAG---LERWFPLL------GAPAGAALRARIRARRLR 425
Query: 443 ILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVM 502
+LP E+YKE AEF+T +Y LC LEP + + KEELA A+V +L++TGRA+ +TDL
Sbjct: 426 VLPSERYKELAEFLTFHYARLCGALEPALPAQAKEELAAAMVRVLRATGRAQALVTDLGT 485
Query: 503 SEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK 562
+E+ RCG + L+FRENT+ATK+I+EY+KLV Q YL + LG+ ++ L S E+CEVDPSK
Sbjct: 486 AELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLGQVVRRLCASTEDCEVDPSK 545
Query: 563 CSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLIS 622
C +SEL +HQ+ L+ CE F II+SY FP EL VF+SW++ C RG + + RL+
Sbjct: 546 CPASELPEHQARLRNSCEEVFETIIHSYDWFPAELGIVFSSWREACKERGSEVLGPRLVC 605
Query: 623 ASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMN 682
ASLFLR LCPAI++PSLF L ++P +RTLTLIAKVIQNLAN A FG KE YM FMN
Sbjct: 606 ASLFLRLLCPAILAPSLFGLAPDHPAPGPARTLTLIAKVIQNLANRAPFGEKEAYMGFMN 665
Query: 683 DFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAK 742
FLE M+ FL +++ D + G+ G DL +L+VLH+ L + ++LD+ T
Sbjct: 666 SFLEEHGPAMQCFLDQVAMVDVDAAPSGYQGSGDLALQLAVLHAQLCTIFAELDQTTRDT 725
Query: 743 LGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLH 800
L PLP +L I + P + +R V SLS+G + F P D H
Sbjct: 726 LEPLPTILRAIEEG--QPVLVSVPMRL---PLPPAQVHSSLSAGEKPGFLAPRDLPKH 778
Score = 33.5 bits (75), Expect = 1.3
Identities = 52/222 (23%), Positives = 83/222 (37%), Gaps = 24/222 (10%)
Query: 996 IPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASL--RSTGSMSVVSAALVAEPV 1053
+P+ LP AQ+ G AP LP L +S SV + A P
Sbjct: 746 VPMRLPLP----PAQVHSSLSAGEKPGFLAPRDLPKHTPLISKSQSLRSVRRSESWARPR 801
Query: 1054 QNGSRS-RQQSSSSRESPVPKVRAIQRQQTQQV-QSPVDSATMSPVERTAAWVLNNGQYE 1111
+ R R+ R VP R +R+Q+ P S +M P R W ++
Sbjct: 802 PDEERPLRRPRPVQRTQSVPVRRPARRRQSAGPWPRPKGSLSMGPAPRARPWTRDSASLP 861
Query: 1112 EDVEET-EQNLDEAKHAEKY---EQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLL 1167
++ +D+ + + + + KL E + E L +EQ++ L+
Sbjct: 862 RKPSVPWQRQMDQPQDRNQALGTHRPVNKLAEL---------QCEVAALREEQKVLSRLV 912
Query: 1168 EYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDH 1209
E L L QQE+ Q++ + SRL A E +H
Sbjct: 913 E---SLSTQIRALTEQQEQLRGQLQDLDSRLRAGSSEFDSEH 951
>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
Length = 1047
Score = 178 bits (451), Expect = 3e-44
Identities = 141/491 (28%), Positives = 241/491 (49%), Gaps = 38/491 (7%)
Query: 260 SVKPLHSSILGQDFCFEVTYLSGSK-----CFSCNSASERDKWMENLR-----RTVQPNK 309
SV +H S+ G+ CF++ S+ F+ + + + WM+ L+ R P
Sbjct: 526 SVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGT 585
Query: 310 DNCR-RAENVLRLWIIEAKDLAPKKKY---FCELCLDDTLFARTTSKTKADNIFWGEHFE 365
N R R + L L I EA L P K + +C + L+ A+T ++ + N W E F
Sbjct: 586 SNKRLRQVSSLVLHIEEAHKL-PVKHFTNPYCNIYLNSVQVAKTHAR-EGQNPVWSEEFV 643
Query: 366 FFSLPPLHSITVHIYK-DVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNK 424
F LPP ++ ++ + K KK K+ + + + + ++W+ +S+ P K
Sbjct: 644 FDDLPP----DINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLK 699
Query: 425 GKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALV 484
G G S+R+++R+ I+P E+Y EF E + + L V +++ LA L+
Sbjct: 700 GIEPG-SLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCG-QDRTLLASILL 757
Query: 485 HILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGE 544
I L L E+ E L FR T+A+ +E+Y+K Q++H AL +
Sbjct: 758 RIFLHEKLESLLLCTLNDREISMEDEATTL-FRATTLASTLMEQYMKATATQFVHHALKD 816
Query: 545 FIKALYESDENCEVDPSKCSSSELIDHQSN--LKMCCELAFCKIINSYCVFPRELKEVFA 602
I + ES ++CE+ PSK +E ++ L + EL KI + + P L+ ++
Sbjct: 817 SILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVE-KIFMASEILPPTLRYIYG 875
Query: 603 SWKQQCLNRGKQDIS--ERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK 660
++ ++ + + R++S +FLR +CPAI++P +FN++ + P +RTL L+AK
Sbjct: 876 CLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAK 935
Query: 661 VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISN----PDTISNTPGFDGYID 716
+QNLAN +FG KE YM +N F++ M FL E+ N PDT ++ D
Sbjct: 936 SVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHS-----RTD 990
Query: 717 LGRELSVLHSL 727
L R+L+ LH +
Sbjct: 991 LSRDLAALHEI 1001
>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
Length = 870
Score = 178 bits (451), Expect = 3e-44
Identities = 141/491 (28%), Positives = 241/491 (49%), Gaps = 38/491 (7%)
Query: 260 SVKPLHSSILGQDFCFEVTYLSGSK-----CFSCNSASERDKWMENLR-----RTVQPNK 309
SV +H S+ G+ CF++ S+ F+ + + + WM+ L+ R P
Sbjct: 349 SVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGT 408
Query: 310 DNCR-RAENVLRLWIIEAKDLAPKKKY---FCELCLDDTLFARTTSKTKADNIFWGEHFE 365
N R R + L L I EA L P K + +C + L+ A+T ++ + N W E F
Sbjct: 409 SNKRLRQVSSLVLHIEEAHKL-PVKHFTNPYCNIYLNSVQVAKTHAR-EGQNPVWSEEFV 466
Query: 366 FFSLPPLHSITVHIYK-DVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNK 424
F LPP ++ ++ + K KK K+ + + + + ++W+ +S+ P K
Sbjct: 467 FDDLPP----DINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLK 522
Query: 425 GKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALV 484
G G S+R+++R+ I+P E+Y EF E + + L V +++ LA L+
Sbjct: 523 GIEPG-SLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCG-QDRTLLASILL 580
Query: 485 HILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGE 544
I L L E+ E L FR T+A+ +E+Y+K Q++H AL +
Sbjct: 581 RIFLHEKLESLLLCTLNDREISMEDEATTL-FRATTLASTLMEQYMKATATQFVHHALKD 639
Query: 545 FIKALYESDENCEVDPSKCSSSELIDHQSN--LKMCCELAFCKIINSYCVFPRELKEVFA 602
I + ES ++CE+ PSK +E ++ L + EL KI + + P L+ ++
Sbjct: 640 SILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVE-KIFMASEILPPTLRYIYG 698
Query: 603 SWKQQCLNRGKQDIS--ERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK 660
++ ++ + + R++S +FLR +CPAI++P +FN++ + P +RTL L+AK
Sbjct: 699 CLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAK 758
Query: 661 VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISN----PDTISNTPGFDGYID 716
+QNLAN +FG KE YM +N F++ M FL E+ N PDT ++ D
Sbjct: 759 SVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHS-----RTD 813
Query: 717 LGRELSVLHSL 727
L R+L+ LH +
Sbjct: 814 LSRDLAALHEI 824
>gi|239743309 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 731
Score = 132 bits (333), Expect = 2e-30
Identities = 116/406 (28%), Positives = 187/406 (46%), Gaps = 52/406 (12%)
Query: 300 NLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIF 359
+LR V P CR LR ++EA+DLAPK + D + R +T+ +I
Sbjct: 49 HLRLEVWPGARACR-----LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIV 100
Query: 360 -------WGEHFEF-FSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFV 411
W E FEF + ++ V + +N+++G V I + Q
Sbjct: 101 KKSCYPRWNETFEFELQEGAMEALCVEAWD----WDLVSRNDFLGKVVIDVQRLRVVQQE 156
Query: 412 EKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQYKEFAEFVTSNYTM----- 462
E W+ + P +K + S++++ R + T+LP Y+ + +
Sbjct: 157 EGWFRLQ-PDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGP 215
Query: 463 --LCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENT 520
L ++E S ++++A L+ + G AKDFL L E+ R E + L FR N+
Sbjct: 216 GQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNS 274
Query: 521 IATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK-------CSS-------S 566
+A+KS+E +LK+ G QYLH LG I ++E + E+DPSK CS +
Sbjct: 275 LASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEA 334
Query: 567 ELIDHQSN-LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR--GKQDISERLISA 623
E+++ + L+ + S P ++ F ++ R G Q + I+
Sbjct: 335 EVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAV 394
Query: 624 SLFL--RFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLAN 667
+ FL RF PAIMSP LF+L + + D RTSRTL L+AK +QN+ N
Sbjct: 395 TSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGN 440
>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 757
Score = 132 bits (333), Expect = 2e-30
Identities = 116/406 (28%), Positives = 187/406 (46%), Gaps = 52/406 (12%)
Query: 300 NLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIF 359
+LR V P CR LR ++EA+DLAPK + D + R +T+ +I
Sbjct: 121 HLRLEVWPGARACR-----LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIV 172
Query: 360 -------WGEHFEF-FSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFV 411
W E FEF + ++ V + +N+++G V I + Q
Sbjct: 173 KKSCYPRWNETFEFELQEGAMEALCVEAWD----WDLVSRNDFLGKVVIDVQRLRVVQQE 228
Query: 412 EKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQYKEFAEFVTSNYTM----- 462
E W+ + P +K + S++++ R + T+LP Y+ + +
Sbjct: 229 EGWFRLQ-PDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGP 287
Query: 463 --LCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENT 520
L ++E S ++++A L+ + G AKDFL L E+ R E + L FR N+
Sbjct: 288 GQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNS 346
Query: 521 IATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK-------CSS-------S 566
+A+KS+E +LK+ G QYLH LG I ++E + E+DPSK CS +
Sbjct: 347 LASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEA 406
Query: 567 ELIDHQSN-LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR--GKQDISERLISA 623
E+++ + L+ + S P ++ F ++ R G Q + I+
Sbjct: 407 EVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAV 466
Query: 624 SLFL--RFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLAN 667
+ FL RF PAIMSP LF+L + + D RTSRTL L+AK +QN+ N
Sbjct: 467 TSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGN 512
Score = 32.3 bits (72), Expect = 3.0
Identities = 14/56 (25%), Positives = 27/56 (48%)
Query: 324 IEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHI 379
+ AKD+ +C + +D+ RT + K FWGE ++ P H++ ++
Sbjct: 17 LPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFHAVAFYV 72
>gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 731
Score = 132 bits (333), Expect = 2e-30
Identities = 116/406 (28%), Positives = 187/406 (46%), Gaps = 52/406 (12%)
Query: 300 NLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIF 359
+LR V P CR LR ++EA+DLAPK + D + R +T+ +I
Sbjct: 49 HLRLEVWPGARACR-----LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIV 100
Query: 360 -------WGEHFEF-FSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFV 411
W E FEF + ++ V + +N+++G V I + Q
Sbjct: 101 KKSCYPRWNETFEFELQEGAMEALCVEAWD----WDLVSRNDFLGKVVIDVQRLRVVQQE 156
Query: 412 EKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQYKEFAEFVTSNYTM----- 462
E W+ + P +K + S++++ R + T+LP Y+ + +
Sbjct: 157 EGWFRLQ-PDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGP 215
Query: 463 --LCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENT 520
L ++E S ++++A L+ + G AKDFL L E+ R E + L FR N+
Sbjct: 216 GQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNS 274
Query: 521 IATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK-------CSS-------S 566
+A+KS+E +LK+ G QYLH LG I ++E + E+DPSK CS +
Sbjct: 275 LASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEA 334
Query: 567 ELIDHQSN-LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR--GKQDISERLISA 623
E+++ + L+ + S P ++ F ++ R G Q + I+
Sbjct: 335 EVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAV 394
Query: 624 SLFL--RFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLAN 667
+ FL RF PAIMSP LF+L + + D RTSRTL L+AK +QN+ N
Sbjct: 395 TSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGN 440
>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 757
Score = 132 bits (333), Expect = 2e-30
Identities = 116/406 (28%), Positives = 187/406 (46%), Gaps = 52/406 (12%)
Query: 300 NLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIF 359
+LR V P CR LR ++EA+DLAPK + D + R +T+ +I
Sbjct: 121 HLRLEVWPGARACR-----LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIV 172
Query: 360 -------WGEHFEF-FSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFV 411
W E FEF + ++ V + +N+++G V I + Q
Sbjct: 173 KKSCYPRWNETFEFELQEGAMEALCVEAWD----WDLVSRNDFLGKVVIDVQRLRVVQQE 228
Query: 412 EKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQYKEFAEFVTSNYTM----- 462
E W+ + P +K + S++++ R + T+LP Y+ + +
Sbjct: 229 EGWFRLQ-PDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGP 287
Query: 463 --LCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENT 520
L ++E S ++++A L+ + G AKDFL L E+ R E + L FR N+
Sbjct: 288 GQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNS 346
Query: 521 IATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK-------CSS-------S 566
+A+KS+E +LK+ G QYLH LG I ++E + E+DPSK CS +
Sbjct: 347 LASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEA 406
Query: 567 ELIDHQSN-LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR--GKQDISERLISA 623
E+++ + L+ + S P ++ F ++ R G Q + I+
Sbjct: 407 EVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAV 466
Query: 624 SLFL--RFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLAN 667
+ FL RF PAIMSP LF+L + + D RTSRTL L+AK +QN+ N
Sbjct: 467 TSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGN 512
Score = 32.3 bits (72), Expect = 3.0
Identities = 14/56 (25%), Positives = 27/56 (48%)
Query: 324 IEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHI 379
+ AKD+ +C + +D+ RT + K FWGE ++ P H++ ++
Sbjct: 17 LPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFHAVAFYV 72
>gi|38201692 RAS p21 protein activator 3 [Homo sapiens]
Length = 834
Score = 132 bits (332), Expect = 2e-30
Identities = 114/389 (29%), Positives = 183/389 (47%), Gaps = 42/389 (10%)
Query: 348 RTTSKTKADNIFWGEHFEF-FSLPPLHSITVHI---YKDVEK----------KKKKDKNN 393
+T K K +N + E F F + P +S H +DV+K K +
Sbjct: 182 KTKVKRKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDE 241
Query: 394 YVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQY 449
++G + IP + E WY + P N K+ P S+R+ + + + Y
Sbjct: 242 FLGELRIPLKVLRQSSSYEAWYFLQ-PRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYY 300
Query: 450 KEFAEFVTSNYTMLCSVLEPVIS---------VRNKEELACALVHILQSTGRAKDFLTDL 500
+ + + + +EPV + R K+E A LV + GR F++ +
Sbjct: 301 SPLRDLLLKS-----ADVEPVSASAAHILGEVCREKQEAAVPLVRLFLHYGRVVPFISAI 355
Query: 501 VMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDP 560
+EV R + + IFR N++A+K I+E +KL G YLH L I+ + +S + CE+DP
Sbjct: 356 ASAEVKRTQDPNT-IFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDP 414
Query: 561 SKCSSSE-LIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISER 619
K E L ++ NL+ + F I S P + ++F S ++ R + D R
Sbjct: 415 VKLKDGENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRFQDDPDVR 474
Query: 620 L--ISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGN---K 674
+S+ +FLRF PAI+SP+LF L + D +TSRTLTLI+K +Q L + +K + K
Sbjct: 475 YTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKSASFK 534
Query: 675 EEYMAFMNDFLEHE--WGGMKRFLLEISN 701
E YMA +F + +K FL IS+
Sbjct: 535 ESYMATFYEFFNEQKYADAVKNFLDLISS 563
>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
Length = 757
Score = 132 bits (331), Expect = 3e-30
Identities = 116/406 (28%), Positives = 187/406 (46%), Gaps = 52/406 (12%)
Query: 300 NLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIF 359
+LR V P CR LR ++EA+DLAPK + D + R +T+ +I
Sbjct: 121 HLRLEVWPGARACR-----LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIV 172
Query: 360 -------WGEHFEF-FSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFV 411
W E FEF + ++ V + +N+++G V I + Q
Sbjct: 173 KKSCYPRWNETFEFELQEGAMEALCVEAWD----WDLVSRNDFLGKVVIDVQRLRVVQQE 228
Query: 412 EKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQYKEFAEFVTSNYTM----- 462
E W+ + P +K + S++++ R + T+LP Y+ + +
Sbjct: 229 EGWFRLQ-PDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGP 287
Query: 463 --LCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENT 520
L ++E S ++++A L+ + G AKDFL L E+ R E + L FR N+
Sbjct: 288 GQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNS 346
Query: 521 IATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK-------CSS-------S 566
+A+KS+E +LK+ G QYLH LG I ++E + E+DPSK CS +
Sbjct: 347 LASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEA 406
Query: 567 ELIDHQSN-LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR--GKQDISERLISA 623
E+++ + L+ + S P ++ F ++ R G Q + I+
Sbjct: 407 EVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAV 466
Query: 624 SLFL--RFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLAN 667
+ FL RF PAIMSP LF+L + + D RTSRTL L+AK +QN+ N
Sbjct: 467 TSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGN 512
Score = 32.3 bits (72), Expect = 3.0
Identities = 14/56 (25%), Positives = 27/56 (48%)
Query: 324 IEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHI 379
+ AKD+ +C + +D+ RT + K FWGE ++ P H++ ++
Sbjct: 17 LPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFHAVAFYV 72
>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
Length = 803
Score = 132 bits (331), Expect = 3e-30
Identities = 116/406 (28%), Positives = 187/406 (46%), Gaps = 52/406 (12%)
Query: 300 NLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIF 359
+LR V P CR LR ++EA+DLAPK + D + R +T+ +I
Sbjct: 121 HLRLEVWPGARACR-----LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIV 172
Query: 360 -------WGEHFEF-FSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFV 411
W E FEF + ++ V + +N+++G V I + Q
Sbjct: 173 KKSCYPRWNETFEFELQEGAMEALCVEAWD----WDLVSRNDFLGKVVIDVQRLRVVQQE 228
Query: 412 EKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQYKEFAEFVTSNYTM----- 462
E W+ + P +K + S++++ R + T+LP Y+ + +
Sbjct: 229 EGWFRLQ-PDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGP 287
Query: 463 --LCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENT 520
L ++E S ++++A L+ + G AKDFL L E+ R E + L FR N+
Sbjct: 288 GQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNS 346
Query: 521 IATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK-------CSS-------S 566
+A+KS+E +LK+ G QYLH LG I ++E + E+DPSK CS +
Sbjct: 347 LASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEA 406
Query: 567 ELIDHQSN-LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR--GKQDISERLISA 623
E+++ + L+ + S P ++ F ++ R G Q + I+
Sbjct: 407 EVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAV 466
Query: 624 SLFL--RFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLAN 667
+ FL RF PAIMSP LF+L + + D RTSRTL L+AK +QN+ N
Sbjct: 467 TSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGN 512
Score = 32.3 bits (72), Expect = 3.0
Identities = 14/56 (25%), Positives = 27/56 (48%)
Query: 324 IEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHI 379
+ AKD+ +C + +D+ RT + K FWGE ++ P H++ ++
Sbjct: 17 LPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFHAVAFYV 72
>gi|12545408 RAS p21 protein activator 2 [Homo sapiens]
Length = 849
Score = 113 bits (282), Expect = 1e-24
Identities = 91/330 (27%), Positives = 161/330 (48%), Gaps = 22/330 (6%)
Query: 394 YVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQY 449
++G + +P + + WY + P N K+ S+R+ + +LP E Y
Sbjct: 268 FLGEIKVPVNVLRTDSSHQAWYLLQ-PRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYY 326
Query: 450 KEFAEFVTSNYTM--LCSVLEPVIS--VRNKEELACALVHILQSTGRAKDFLTDLVMSEV 505
+ + + + + ++S R+K + LV +L + F T ++E+
Sbjct: 327 GPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLVPFAT--AVAEL 384
Query: 506 DRCGEHDV-LIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCS 564
D D IFR N++AT+ ++E +K+VG YL L + + +S ++CE+DP K
Sbjct: 385 DLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLK 444
Query: 565 SSELIDH-QSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQD--ISERLI 621
+ +++ + NL+ + F I+ S P + ++F S +Q R D + +
Sbjct: 445 EGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAV 504
Query: 622 SASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANF-----AKFGNKEE 676
S+ +FLRF A++SP F+L +PD +T RTLTLI+K IQ L ++ +K KE
Sbjct: 505 SSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKSSFKET 564
Query: 677 YMA-FMNDFLEHEW-GGMKRFLLEISNPDT 704
+M F F E + +K+FL EIS+ +T
Sbjct: 565 FMCEFFKMFQEEGYIIAVKKFLDEISSTET 594
>gi|4759026 RAS protein activator like 1 [Homo sapiens]
Length = 804
Score = 110 bits (276), Expect = 7e-24
Identities = 107/405 (26%), Positives = 185/405 (45%), Gaps = 46/405 (11%)
Query: 319 LRLWIIEAKDLAPKK------KYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPL 372
LR ++ A+DLAP+ + +L T KT+ + W E E +P
Sbjct: 135 LRCHVLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPH--WDEVLELREMPGA 192
Query: 373 HSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSI 432
S + ++ KN+++G+V ++ + + W+ + P P + G ++
Sbjct: 193 PS---PLRVELWDWDMVGKNDFLGMVEFSPKTLQQKP-PKGWFRL-LPFPRAEEDSGGNL 247
Query: 433 ---RIKSRFQTITILPMEQYKEFAEFVTSNY--------TMLCSVLEPVISVRNKEELAC 481
R+K R +LP + Y+ E + + ++LE + +++LA
Sbjct: 248 GALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGDCRQDLAT 307
Query: 482 ALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDA 541
LV + G A FL L EV R + + L FR N++A+KS+E+++KLVG YLH+
Sbjct: 308 KLVKLFLGRGLAGHFLDYLTRREVARTMDPNTL-FRSNSLASKSMEQFMKLVGMPYLHEV 366
Query: 542 LGEFIKALYESDENCEVDPSKC------------SSSELIDHQSNLKMCCEL---AFCKI 586
L I ++E + E+DP K + SE +++L + I
Sbjct: 367 LKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLGPIVDAI 426
Query: 587 INSYCVFPRELKEVFASWKQQCLNR----GKQDISERLISASLFLRFLCPAIMSPSLFNL 642
+ S P ++ F ++ R QD+ IS LFLRF PAI++P LF+L
Sbjct: 427 VGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAILTPKLFDL 486
Query: 643 MQEYPDDRTSRTLTLIAKVIQNLANFAK--FGNKEEYMAFMNDFL 685
++ D +TSR+L L+AK +Q++ N + KE +MA ++ FL
Sbjct: 487 RDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFL 531
Score = 33.9 bits (76), Expect = 1.0
Identities = 19/101 (18%), Positives = 47/101 (46%), Gaps = 5/101 (4%)
Query: 324 IEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDV 383
+ AKD++ +C + +DD + ART + ++ FWGE + H + ++ +
Sbjct: 17 LPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVHLPLDFHQLAFYVLDE- 75
Query: 384 EKKKKKDKNNYVGLVNIPTASVTG-RQFVEKWYPVSTPTPN 423
++ +G +++ ++T + ++ W +S P+
Sbjct: 76 ---DTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPD 113
>gi|4557793 neurofibromin isoform 2 [Homo sapiens]
Length = 2818
Score = 108 bits (270), Expect = 3e-23
Identities = 88/293 (30%), Positives = 143/293 (48%), Gaps = 14/293 (4%)
Query: 447 EQYKEFAEFVT----SNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVM 502
++++ E VT + L V+ +ELA LV + S L ++
Sbjct: 1203 DRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFS 1262
Query: 503 SEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDE----NCEV 558
EV+ L FR N++A+K + K+ G YL L ++ + S + + EV
Sbjct: 1263 KEVELADSMQTL-FRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFEV 1321
Query: 559 DPSKCSSSE-LIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDIS 617
DP++ SE L ++Q NL E F II+S FP +L+ V Q R Q+ S
Sbjct: 1322 DPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQN-S 1380
Query: 618 ERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEY 677
+ +++FLRF+ PAI+SP ++ + P R R L L++K++Q++AN F KEE+
Sbjct: 1381 IGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLF-TKEEH 1439
Query: 678 MAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFD-GYIDLGRELSVLHSLLW 729
M NDF++ + +RF L+I++ S+ +I G L+ LH LLW
Sbjct: 1440 MRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFISDGNVLA-LHRLLW 1491
>gi|109826564 neurofibromin isoform 1 [Homo sapiens]
Length = 2839
Score = 103 bits (258), Expect = 8e-22
Identities = 89/313 (28%), Positives = 148/313 (47%), Gaps = 33/313 (10%)
Query: 447 EQYKEFAEFVT----SNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVM 502
++++ E VT + L V+ +ELA LV + S L ++
Sbjct: 1203 DRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFS 1262
Query: 503 SEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDE----NCEV 558
EV+ L FR N++A+K + K+ G YL L ++ + S + + EV
Sbjct: 1263 KEVELADSMQTL-FRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFEV 1321
Query: 559 DPSKCSSSE-LIDHQSNLKMCCELAFCKIINSYCVFPRELKEV----FASWKQQCLNRG- 612
DP++ SE L ++Q NL E F II+S FP +L+ V + + LN+
Sbjct: 1322 DPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKAT 1381
Query: 613 --------KQDISERL-------ISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTL 657
K +S+R + +++FLRF+ PAI+SP ++ + P R R L L
Sbjct: 1382 VKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKL 1441
Query: 658 IAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFD-GYID 716
++K++Q++AN F KEE+M NDF++ + +RF L+I++ S+ +I
Sbjct: 1442 MSKILQSIANHVLF-TKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFIS 1500
Query: 717 LGRELSVLHSLLW 729
G L+ LH LLW
Sbjct: 1501 DGNVLA-LHRLLW 1512
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 61.2 bits (147), Expect = 6e-09
Identities = 52/184 (28%), Positives = 81/184 (44%), Gaps = 20/184 (10%)
Query: 1057 SRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEED--- 1113
++ + E PK +I Q V+ V+ T E T L NGQ +
Sbjct: 183 NKKEDKEKEEEEEEKPKRGSIGENQ---VEVMVEEKTTESQEETVVMSLKNGQISSEEPK 239
Query: 1114 -VEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKAR 1172
EE EQ DE H EK E+E KER RLE ER + EQ K + + +AR
Sbjct: 240 QEEEREQGSDEISHHEKMEEED---KERAEAERARLEAEERERIKAEQ--DKKIADERAR 294
Query: 1173 LEDSE-----ERLRRQQEEKD---SQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIID 1224
+E E ER RR+ EE++ + K ++EE K+ E Q + + +++ +
Sbjct: 295 IEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAE 354
Query: 1225 AQEK 1228
+++
Sbjct: 355 ERQR 358
Score = 40.0 bits (92), Expect = 0.014
Identities = 65/363 (17%), Positives = 142/363 (39%), Gaps = 33/363 (9%)
Query: 942 DSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALP 1001
D++ + +S+S E +++ + + + + K + + +++ P
Sbjct: 140 DTAENETTEKEEKSESRQERYEIE-ETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKP 198
Query: 1002 RQNSTGQAQIR-KVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSR 1060
++ S G+ Q+ V++ ++ + + + S ++ + + +
Sbjct: 199 KRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKME 258
Query: 1061 QQSSSSRESPVPKVRAIQRQQTQQVQSPV---DSATMSPVERTAAWVLNNGQYEED---- 1113
++ E+ ++ A +R++ + Q + A + E+ AA + EE
Sbjct: 259 EEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMR 318
Query: 1114 ------VEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLL 1167
EE ++ +E K A + Q I + ++R +R++E E+R +E+Q +
Sbjct: 319 EEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRA-AEERQRARAEE 377
Query: 1168 EYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEE--------ELKKDHAEMQAVIDAK 1219
E KA++E E++ +Q EEK M+ + VE+ E K ++Q + K
Sbjct: 378 EEKAKVE--EQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKK 435
Query: 1220 Q---KIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITE----N 1272
Q K Q KR + T + K + + + + K TE N
Sbjct: 436 QGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQN 495
Query: 1273 GEF 1275
GEF
Sbjct: 496 GEF 498
Score = 36.6 bits (83), Expect = 0.16
Identities = 34/167 (20%), Positives = 76/167 (45%), Gaps = 17/167 (10%)
Query: 1116 ETEQNLDEAKH--AEKYEQEITKLKERLRVSSRRLEEY-----ERRLLVQEQQMQKLLLE 1168
E + L+E + E +E KLK++ + ++ LEE ERR +++E++ ++ E
Sbjct: 531 EAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE 590
Query: 1169 YKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAV--------IDAKQ 1220
+L + EE+ R ++E + + ++ R E+ L D + I+ +
Sbjct: 591 ADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERA 650
Query: 1221 KIIDAQEKRIVSLDSAN-TRLMSALTQVKERYSMQVRNGISPTNPTK 1266
+ ++ ++ + S + ++S + E+Y+ + G PTK
Sbjct: 651 EFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAI-EGTKSAKPTK 696
Score = 32.0 bits (71), Expect = 3.9
Identities = 24/80 (30%), Positives = 39/80 (48%), Gaps = 6/80 (7%)
Query: 1112 EDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKA 1171
E+ E+ +Q EA E+ +LK++ + LEE E+R +E + E K
Sbjct: 549 EEFEKLKQKQQEAA------LELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKR 602
Query: 1172 RLEDSEERLRRQQEEKDSQM 1191
RL++ ER R + EK +M
Sbjct: 603 RLKEEIERRRAEAAEKRQKM 622
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 58.5 bits (140), Expect = 4e-08
Identities = 48/168 (28%), Positives = 85/168 (50%), Gaps = 15/168 (8%)
Query: 1073 KVRAIQRQQTQQVQSPVDSA---TMSPVERTAAWVLNNGQYEEDVEETEQNL-DEAKHAE 1128
KV +Q +T ++ ++S + VE L N + EE + E E+ L ++ +
Sbjct: 158 KVEQLQ-DETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLREQEERLR 216
Query: 1129 KYEQEITKLKERLRVSSRRLEEYERRLLVQEQQM---QKLLLEYKARLEDSEERLRRQQE 1185
+ E+ + + +ERLR RL E E RL QE+++ ++ L E + RL + EERLR Q+E
Sbjct: 217 EQEERLCEQEERLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEE 276
Query: 1186 EKDSQMKSIISRLMAVEEELKKDH---AEMQAVIDAKQKIIDAQEKRI 1230
Q + RL EE L++ E + + +++ + QE+R+
Sbjct: 277 RLHEQEE----RLCEQEERLREQEERLCEQEERLREQEERLCEQEERL 320
Score = 45.1 bits (105), Expect = 4e-04
Identities = 34/128 (26%), Positives = 70/128 (54%), Gaps = 10/128 (7%)
Query: 1109 QYEEDVEETEQNL-DEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQM---QK 1164
+ EE + E E+ L ++ + + E+ + + +ERL RL E E RL QE+++ ++
Sbjct: 245 EQEERLREHEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEE 304
Query: 1165 LLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEE-----ELKKDHAEMQAVIDAK 1219
L E + RL + EERL R+QEE+ + + + + +EE E ++ E + +++ +
Sbjct: 305 RLREQEERLCEQEERL-REQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERE 363
Query: 1220 QKIIDAQE 1227
+ + + +E
Sbjct: 364 RLLEEVEE 371
Score = 43.5 bits (101), Expect = 0.001
Identities = 33/111 (29%), Positives = 60/111 (54%), Gaps = 8/111 (7%)
Query: 1109 QYEEDVEETEQNL-DEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQM--QKL 1165
+ EE + E E+ L ++ + + E+ + + +ERLR RL E E RL QE+++ Q+
Sbjct: 273 EQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEK 332
Query: 1166 LLEYKARLEDSEERLRRQQEEKDSQMKSIISR---LMAVEEELKKDHAEMQ 1213
L + LE+ E+ L +QE + + + ++ R L VEE L+++ Q
Sbjct: 333 LPGQERLLEEVEKLL--EQERRQEEQERLLERERLLEEVEELLEQERLRQQ 381
Score = 42.4 bits (98), Expect = 0.003
Identities = 37/106 (34%), Positives = 59/106 (55%), Gaps = 9/106 (8%)
Query: 1109 QYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQE--QQMQKLL 1166
+ EE + E E+ L E + + ++E +E+L R LEE E +LL QE Q+ Q+ L
Sbjct: 301 EQEERLREQEERLCEQEERLREQEERLCEQEKLPGQERLLEEVE-KLLEQERRQEEQERL 359
Query: 1167 LEYKARLEDSEERLR----RQQEEKDSQMKSI--ISRLMAVEEELK 1206
LE + LE+ EE L RQQ+E+ Q +++ + RL +E L+
Sbjct: 360 LERERLLEEVEELLEQERLRQQDERLWQQETLQELERLRELERMLE 405
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sapiens]
Length = 570
Score = 55.5 bits (132), Expect = 3e-07
Identities = 37/190 (19%), Positives = 94/190 (49%), Gaps = 14/190 (7%)
Query: 1051 EPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQY 1110
E + + R+Q +E K+R +++Q Q+ + + E Q
Sbjct: 351 EKMHEQEKIREQEEKRQEEE--KIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQE 408
Query: 1111 EEDV--EETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKL--- 1165
+E+ E+ E+ ++ + ++ E+++ + +E++R +++ E E ++ QE+ MQ+
Sbjct: 409 QEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEK 468
Query: 1166 -------LLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDA 1218
+ E +A++++ EE++RRQ+E+ Q K I + + E+ + + + + +
Sbjct: 469 MGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQ 528
Query: 1219 KQKIIDAQEK 1228
++K+ + +EK
Sbjct: 529 EEKMCEQEEK 538
Score = 45.8 bits (107), Expect = 3e-04
Identities = 29/131 (22%), Positives = 68/131 (51%), Gaps = 9/131 (6%)
Query: 1109 QYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQM---QKL 1165
Q EE + E E+ ++ + E++I + +E++R ++E E ++ QE++M ++
Sbjct: 367 QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEE 426
Query: 1166 LLEYKARLEDSEERLR------RQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAK 1219
+ E + ++ EE++R R+QEEK + + ++ E + E +A + +
Sbjct: 427 MQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQ 486
Query: 1220 QKIIDAQEKRI 1230
++ + QE++I
Sbjct: 487 EEKMRRQEEKI 497
Score = 43.1 bits (100), Expect = 0.002
Identities = 29/111 (26%), Positives = 62/111 (55%), Gaps = 17/111 (15%)
Query: 1109 QYEEDVEETEQNL--DEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKL- 1165
+ EE + E E + EAK E+ E+++ + +E++R +++ E E ++ QE+ MQ+
Sbjct: 464 EQEEKMGEQEGKMCEQEAKMQEQ-EEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQE 522
Query: 1166 ---------LLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKK 1207
+ E + ++++ EE++RRQ+E +M+ RL EE++++
Sbjct: 523 EKMWEQEEKMCEQEEKMQEQEEKMRRQEE----KMREQEVRLRQQEEKMQE 569
Score = 40.8 bits (94), Expect = 0.008
Identities = 43/195 (22%), Positives = 90/195 (46%), Gaps = 19/195 (9%)
Query: 1044 VSAALVAEPVQNG--SRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTA 1101
VSA L A+ +N +R QQ K++ + + +Q + + +
Sbjct: 265 VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEM 324
Query: 1102 AWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQ 1161
W + EE + E+ + E E++I +L+E++ + E+ E+R ++ +
Sbjct: 325 MW-----EKEEKMRRQEEMMWEK------EEKIRELEEKMHEQEKIREQEEKRQEEEKIR 373
Query: 1162 MQKLLLEYKARLEDSEERLRRQQE---EKDSQMKSIISRLMAVEEELKKDHAEMQ---AV 1215
Q+ E +A++ EE++R Q+E E++ M+ ++ EE++ + EMQ
Sbjct: 374 EQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEK 433
Query: 1216 IDAKQKIIDAQEKRI 1230
+ +++ I QEK+I
Sbjct: 434 MRRQEEKIREQEKKI 448
Score = 40.0 bits (92), Expect = 0.014
Identities = 27/129 (20%), Positives = 73/129 (56%), Gaps = 11/129 (8%)
Query: 1111 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQM---QKLLL 1167
EE + E E+ + E + + E++ + +E++R +R +E E ++ QE+++ ++ +
Sbjct: 343 EEKIRELEEKMHEQEKIREQEEKRQE-EEKIREQEKR-QEQEAKMWRQEEKIREQEEKIR 400
Query: 1168 EYKARLEDSEERLRRQQE---EKDSQMKSIISRLMAVEEELK---KDHAEMQAVIDAKQK 1221
E + +++ EE++ Q+E E++ +M+ ++ EE+++ K E + I +++
Sbjct: 401 EQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 460
Query: 1222 IIDAQEKRI 1230
++ QE+++
Sbjct: 461 MMQEQEEKM 469
Score = 37.7 bits (86), Expect = 0.071
Identities = 30/175 (17%), Positives = 81/175 (46%), Gaps = 26/175 (14%)
Query: 1060 RQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQ 1119
RQ+ + K+R + + +Q + + + W + EE+++E E+
Sbjct: 378 RQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMW-----EQEEEMQEQEE 432
Query: 1120 NLD-EAKHAEKYEQEITKLKERLRVSSRRLEEYERRL------------LVQEQQ----- 1161
+ + + + E++I + +E++R ++E E ++ +QEQ+
Sbjct: 433 KMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRR 492
Query: 1162 MQKLLLEYKARLEDSEERLRRQQE---EKDSQMKSIISRLMAVEEELKKDHAEMQ 1213
++ + E + ++ + EE++R Q+E E++ +M ++ EE++++ +M+
Sbjct: 493 QEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMR 547
Score = 32.0 bits (71), Expect = 3.9
Identities = 37/172 (21%), Positives = 79/172 (45%), Gaps = 33/172 (19%)
Query: 1116 ETEQNLD----EAKHAEKYEQEITKLK--------------ERLRVSSRRLEEYERRLLV 1157
E EQ L + K A++Y +E+TK + E L+ + +L+E + +
Sbjct: 164 ELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVES 223
Query: 1158 QEQQMQKLLLEYKARLEDSEERLRRQQEEKDS-----QMKSIISRLMAVEEE------LK 1206
++ ++Q + E K +LE ++ L +QQ + ++ +++S+ ++L A EE L
Sbjct: 224 EKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLN 283
Query: 1207 KDHAE----MQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQ 1254
+ E + I +++ I QE++I + R + + +E+ Q
Sbjct: 284 QQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQ 335
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 55.5 bits (132), Expect = 3e-07
Identities = 42/159 (26%), Positives = 79/159 (49%), Gaps = 6/159 (3%)
Query: 1073 KVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQ 1132
K+ A +Q+ ++ QS ++S+ + YEE +E E E K+ + +
Sbjct: 1453 KILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQ---E 1509
Query: 1133 EITKLKERLRVSSRRLEEYER---RLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDS 1189
EI+ L E+L + + E E+ +L V++ ++Q L E +A LE E ++ R Q E +
Sbjct: 1510 EISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQ 1569
Query: 1190 QMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEK 1228
I +L +EE+++ Q V+D+ Q +DA+ +
Sbjct: 1570 IKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETR 1608
Score = 41.6 bits (96), Expect = 0.005
Identities = 40/172 (23%), Positives = 73/172 (42%), Gaps = 11/172 (6%)
Query: 1114 VEETEQNLDEAKHAE-KYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKAR 1172
+EE E+ L+ + A K E+ + L L S RLEE VQ + +K E++
Sbjct: 1117 IEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKM 1176
Query: 1173 LEDSEER----------LRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKI 1222
D EE LR++ + +++ I L V+++L+K+ +E + +D
Sbjct: 1177 RRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSN 1236
Query: 1223 IDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGE 1274
++ K +L+ + L + + + R+ T TENGE
Sbjct: 1237 MEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGE 1288
Score = 41.2 bits (95), Expect = 0.006
Identities = 57/271 (21%), Positives = 116/271 (42%), Gaps = 44/271 (16%)
Query: 974 DFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQ---GGLGARAKAPPSLP 1030
D +++++ ED ++ + L L ++ QA+I ++++ ARAK
Sbjct: 1088 DINQQNSKIED--------EQVLALQLQKKLKENQARIEELEEELEAERTARAKVE---- 1135
Query: 1031 HSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVD 1090
LRS S + + E + + + + RE+ K+R + T Q ++
Sbjct: 1136 ---KLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1192
Query: 1091 SATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYE--------QEITKLKERLR 1142
+ ++ A V G+ ++++ +Q L++ K K E ++I K K L
Sbjct: 1193 ALR----KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLE 1248
Query: 1143 VSSRRLEEYERRLLVQEQQMQKLLLEY---KARLEDSEERLRRQQEEKDSQMKSIISRLM 1199
SR LE+ V+ ++ Q+ L ++ +A+L+ L RQ EEK++ + + +
Sbjct: 1249 KVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKL 1308
Query: 1200 A-----------VEEELKKDHAEMQAVIDAK 1219
+ +EEE K +A A+ A+
Sbjct: 1309 SYTQQMEDLKRQLEEEGKAKNALAHALQSAR 1339
Score = 38.9 bits (89), Expect = 0.032
Identities = 63/341 (18%), Positives = 123/341 (36%), Gaps = 47/341 (13%)
Query: 939 ASIDSSLENLSTASSRSQSNSEDFKLS-GPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIP 997
A + ++NL + + +FKL S+ME K E SR T+ D+
Sbjct: 1203 AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSR--TLEDQANE 1260
Query: 998 LALPRQNS-------TGQAQIRKVDQGGLGARAKAPPSLPHSAS---LRSTGSMSVVSAA 1047
+ + + T Q + + G L + + +L + L T M +
Sbjct: 1261 YRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQ 1320
Query: 1048 LVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNN 1107
L E + + S+ + + + Q ++ + ++ + A W
Sbjct: 1321 LEEEGKAKNALAHALQSARHDCDLLRE---QYEEETEAKAELQRVLSKANSEVAQW---R 1374
Query: 1108 GQYEEDVEETEQNLDEAKH--------AEKYEQEITKLKERLRVSSRRLEEYERRLLV-- 1157
+YE D + + L+EAK AE+ + + L + RL+ L+V
Sbjct: 1375 TKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV 1434
Query: 1158 ------------QEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEEL 1205
+++ K+L E+K + E+S+ L Q+E S + A EE L
Sbjct: 1435 ERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESL 1494
Query: 1206 ------KKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRL 1240
K+++ +Q I + + K + L+ +L
Sbjct: 1495 EHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQL 1535
Score = 38.5 bits (88), Expect = 0.042
Identities = 37/160 (23%), Positives = 74/160 (46%), Gaps = 24/160 (15%)
Query: 1119 QNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKAR---LED 1175
++ + K ++E ++KE L S R +E E +++ Q+ L L+ +A L D
Sbjct: 843 KSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLND 902
Query: 1176 SEER---LRRQQEEKDSQMKSIISRLMAVEE-----------------ELKKDHAEMQAV 1215
+EER L + + + ++++K + RL EE ELKKD +++
Sbjct: 903 AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELT 962
Query: 1216 IDAKQKIIDAQEKRIVSLDSANTRLMSALTQV-KERYSMQ 1254
+ +K A E ++ +L L + ++ KE+ ++Q
Sbjct: 963 LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1002
Score = 35.8 bits (81), Expect = 0.27
Identities = 50/238 (21%), Positives = 108/238 (45%), Gaps = 27/238 (11%)
Query: 1000 LPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRS 1059
L QN++ Q +K++ +++ ++ + ++ AA++AE ++
Sbjct: 1718 LHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELK----- 1772
Query: 1060 RQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQ 1119
++Q +S+ + +++ Q + +Q +D A ++ + + E V E E
Sbjct: 1773 KEQDTSAH---LERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQ---KLEARVRELEG 1826
Query: 1120 NLD-EAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLE---YKARLED 1175
L+ E K + + + K + R++ + + EE ++ LL + + KL L+ YK + E+
Sbjct: 1827 ELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEE 1886
Query: 1176 SEE-------RLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQ 1226
+EE + R+ Q E D + R E ++ K A+ + I AKQK+ D +
Sbjct: 1887 AEEQANTNLSKFRKVQHELDEAEE----RADIAESQVNKLRAKSRD-IGAKQKMHDEE 1939
Score = 35.4 bits (80), Expect = 0.35
Identities = 42/203 (20%), Positives = 92/203 (45%), Gaps = 10/203 (4%)
Query: 1059 SRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQ--YEEDVEE 1116
+ QQ+ + KV ++ + + + Q D E+ L + E D++
Sbjct: 1004 AHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKL 1063
Query: 1117 TEQNLDEAKHAEKYEQEITKLKE-RLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLED 1175
T++++ + ++ + +E K KE + + ++E+ + V Q+QK L E +AR+E+
Sbjct: 1064 TQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQ----VLALQLQKKLKENQARIEE 1119
Query: 1176 SEERL--RRQQEEKDSQMKSIISR-LMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVS 1232
EE L R K +++S +SR L + E L++ I+ +K +K
Sbjct: 1120 LEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRD 1179
Query: 1233 LDSANTRLMSALTQVKERYSMQV 1255
L+ A + + ++++++ V
Sbjct: 1180 LEEATLQHEATAAALRKKHADSV 1202
Score = 34.3 bits (77), Expect = 0.78
Identities = 43/193 (22%), Positives = 91/193 (47%), Gaps = 29/193 (15%)
Query: 1094 MSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYER 1153
M +R V+++ Q D E +N + + +K E ++ +++ +L ++R E ++
Sbjct: 1585 MEQAKRNHQRVVDSLQTSLDAETRSRN-EVLRVKKKMEGDLNEMEIQLSHANRMAAEAQK 1643
Query: 1154 RLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQ 1213
Q + +Q LL + + +L+D+ R ++ + + R ++ EL+ E++
Sbjct: 1644 ----QVKSLQSLLKDTQIQLDDAV----RANDDLKENIAIVERRNNLLQAELE----ELR 1691
Query: 1214 AVID--------AKQKIIDAQEKRIVSLDSANTRLM-------SALTQVKERYSMQVRNG 1258
AV++ A+Q++I+ E R+ L S NT L+ S LTQ++ V+
Sbjct: 1692 AVVEQTERSRKLAEQELIETSE-RVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQEC 1750
Query: 1259 ISPTNPTKLSITE 1271
+ K +IT+
Sbjct: 1751 RNAEEKAKKAITD 1763
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapiens]
Length = 436
Score = 55.1 bits (131), Expect = 4e-07
Identities = 31/111 (27%), Positives = 63/111 (56%), Gaps = 6/111 (5%)
Query: 1108 GQYEEDVEETEQNLDEAKH-AEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQM--QK 1164
G+ EE + + E+ + E + +K E+++ K +E++R ++ E E ++ QE+QM QK
Sbjct: 223 GEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQK 282
Query: 1165 LLLEYKARLEDSEERLRRQQE---EKDSQMKSIISRLMAVEEELKKDHAEM 1212
E + + + EE++R Q+E E++ QM+ ++ EE++ K +M
Sbjct: 283 EQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQM 333
Score = 48.5 bits (114), Expect = 4e-05
Identities = 33/169 (19%), Positives = 81/169 (47%), Gaps = 14/169 (8%)
Query: 1058 RSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEET 1117
+ +++ +E + K +Q +QVQ + E+ + EE + E
Sbjct: 216 QKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQ-EEQVQKQEEQMRKQEEQMREQEEQMREQ 274
Query: 1118 EQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQM----------QKLLL 1167
E+ + + K + E++ + +E++R ++ E E ++ QE+QM ++ +
Sbjct: 275 EEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMW 334
Query: 1168 EYKARLEDSEERLRRQQE---EKDSQMKSIISRLMAVEEELKKDHAEMQ 1213
E K ++ + +E++ +Q+E E++ QM+ ++ EE+++K +M+
Sbjct: 335 EQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMR 383
Score = 46.2 bits (108), Expect = 2e-04
Identities = 31/158 (19%), Positives = 80/158 (50%), Gaps = 8/158 (5%)
Query: 1058 RSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEET 1117
+ +++ +E + K R+Q +Q++ + + E+T Q E+ E+
Sbjct: 244 QKQEEQVQKQEEQMRKQEEQMREQEEQMREQ-EEQMLKQKEQTEQEEQTGEQEEQMREQE 302
Query: 1118 EQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKL---LLEYKARLE 1174
EQ ++ + + E+++ + +E++ ++ E + ++ Q++QM K + E + +++
Sbjct: 303 EQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQ 362
Query: 1175 DSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEM 1212
EE++R+Q+E QM+ ++ EE+++K +M
Sbjct: 363 KQEEQVRKQEE----QMRKQEEQMRKQEEQMRKQEEQM 396
Score = 45.8 bits (107), Expect = 3e-04
Identities = 24/99 (24%), Positives = 55/99 (55%), Gaps = 4/99 (4%)
Query: 1115 EETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLE 1174
E+ EQ ++ + +K E+++ + +E++R ++ E E ++ QE+Q+QK + ++
Sbjct: 203 EQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQK----QEEQMR 258
Query: 1175 DSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQ 1213
EE++R Q+E+ Q + ++ + E+E + E Q
Sbjct: 259 KQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQ 297
Score = 45.1 bits (105), Expect = 4e-04
Identities = 28/147 (19%), Positives = 69/147 (46%), Gaps = 8/147 (5%)
Query: 1051 EPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQY 1110
E + ++ +Q RE ++R + Q +Q + + + W +
Sbjct: 283 EQTEQEEQTGEQEEQMREQE-EQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMW 341
Query: 1111 EEDVE---ETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLL 1167
E+ + + EQ ++ + +K E+++ K +E++R ++ + E ++ QE+QM
Sbjct: 342 EQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMG---- 397
Query: 1168 EYKARLEDSEERLRRQQEEKDSQMKSI 1194
E K ++ + +E++R Q+E+ Q + +
Sbjct: 398 EQKEQMGEQKEQMREQEEQMGEQKEQM 424
Score = 43.9 bits (102), Expect = 0.001
Identities = 25/119 (21%), Positives = 66/119 (55%), Gaps = 13/119 (10%)
Query: 1108 GQYEEDVEETEQNLD-EAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQK-- 1164
G+ EE + E E+ + + + + E+++ K +E++ ++++ E ++ QE+QM+K
Sbjct: 202 GEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQE 261
Query: 1165 -LLLEYKARLEDSEERLRRQQE---------EKDSQMKSIISRLMAVEEELKKDHAEMQ 1213
+ E + ++ + EE++ +Q+E E++ QM+ ++ EE++++ +M+
Sbjct: 262 EQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMR 320
Score = 40.4 bits (93), Expect = 0.011
Identities = 27/134 (20%), Positives = 67/134 (50%), Gaps = 8/134 (5%)
Query: 1060 RQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNN--GQYEEDVEET 1117
R+Q RE ++R + Q +Q + + ++ W G+ EE +++
Sbjct: 306 REQEEQMREQE-EQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQ 364
Query: 1118 EQNL-DEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDS 1176
E+ + + + K E+++ K +E++R ++ E + ++ Q++QM+ E + ++ +
Sbjct: 365 EEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMR----EQEEQMGEQ 420
Query: 1177 EERLRRQQEEKDSQ 1190
+E++R+Q+E Q
Sbjct: 421 KEQMRKQEEHMGEQ 434
Score = 39.7 bits (91), Expect = 0.019
Identities = 26/128 (20%), Positives = 71/128 (55%), Gaps = 15/128 (11%)
Query: 1108 GQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLL 1167
G+ E + E E+ + E E+++ K +E++ ++ + E ++ QE+Q+QK
Sbjct: 195 GEQEGQMGEQEEQMGEQ------EEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQK--- 245
Query: 1168 EYKARLEDSEERLRRQQE---EKDSQMKSIISRLMAVEEELKKDH--AEMQAVIDAKQKI 1222
+ +++ EE++R+Q+E E++ QM+ +++ +E+ +++ E + + +++
Sbjct: 246 -QEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQ 304
Query: 1223 IDAQEKRI 1230
+ QE+++
Sbjct: 305 MREQEEQM 312
Score = 38.9 bits (89), Expect = 0.032
Identities = 25/109 (22%), Positives = 59/109 (54%), Gaps = 8/109 (7%)
Query: 1109 QYEEDVEETEQNLDEAK-HAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLL 1167
+ E V E E + E + + E ++ + + ++ ++ E E ++ QE+QMQK
Sbjct: 161 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQK--- 217
Query: 1168 EYKARLEDSEERLRRQQE---EKDSQMKSIISRLMAVEEELKKDHAEMQ 1213
+ ++ + EE++R+Q+E E++ Q++ ++ EE+++K +M+
Sbjct: 218 -QEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMR 265
Score = 36.2 bits (82), Expect = 0.21
Identities = 27/125 (21%), Positives = 67/125 (53%), Gaps = 13/125 (10%)
Query: 1109 QYEEDVEETEQNLDEAK-HAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLL 1167
+ E V E E + E + + E ++ + +E++ ++++ E ++ QE+QM+K
Sbjct: 175 EQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRK--- 231
Query: 1168 EYKARLEDSEERLRRQQEE---KDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIID 1224
+ ++ + EE++++Q+E+ ++ QM+ ++ EE++++ +M KQK
Sbjct: 232 -QEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQM-----LKQKEQT 285
Query: 1225 AQEKR 1229
QE++
Sbjct: 286 EQEEQ 290
Score = 33.9 bits (76), Expect = 1.0
Identities = 28/149 (18%), Positives = 69/149 (46%), Gaps = 9/149 (6%)
Query: 1109 QYEEDVEETEQNLDEAK-HAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLL 1167
+ E V E E + E + + E ++ + + ++R ++ E E ++ QE QM
Sbjct: 140 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMG---- 195
Query: 1168 EYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQE 1227
E + ++ + EE++ Q+E+ Q + + + EE+++K +M + QK + +
Sbjct: 196 EQEGQMGEQEEQMGEQEEQMQKQEEQMGEQ----EEQMRKQEEQMGEQEEQVQKQEEQVQ 251
Query: 1228 KRIVSLDSANTRLMSALTQVKERYSMQVR 1256
K+ + ++ Q++E+ ++
Sbjct: 252 KQEEQMRKQEEQMREQEEQMREQEEQMLK 280
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 54.7 bits (130), Expect = 6e-07
Identities = 40/166 (24%), Positives = 86/166 (51%), Gaps = 17/166 (10%)
Query: 1070 PVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEK 1129
P +++A +++QS V + + VE W N Q EE + E+ + E
Sbjct: 259 PQQQLQAEADHLGKELQS-VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE------ 311
Query: 1130 YEQEITKLKERLRVSSRRLEEYERRLLVQEQQM---QKLLLEYKARLEDSEERLRRQQE- 1185
+E++I + +E++R ++ E E ++ QE+ M ++ + + + + EE++RRQ+E
Sbjct: 312 WEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEM 371
Query: 1186 --EKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKR 1229
EK+ +M+ + EE+++ E++ + ++KI + +EKR
Sbjct: 372 MWEKEEKMRRQEEMMWEKEEKIR----ELEEKMHEQEKIREQEEKR 413
Score = 47.8 bits (112), Expect = 7e-05
Identities = 30/159 (18%), Positives = 78/159 (49%), Gaps = 7/159 (4%)
Query: 1058 RSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEET 1117
R +++ +E + K R+Q +++Q + + + Q E+ E+
Sbjct: 594 REQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQE 653
Query: 1118 EQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSE 1177
E+ ++ + ++ E+ + + +E++R +++ E E ++ QE+ MQ E + ++ + E
Sbjct: 654 EKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQ----EQEEKMWEQE 709
Query: 1178 ERLRRQQE---EKDSQMKSIISRLMAVEEELKKDHAEMQ 1213
E++ Q+E E++ +M+ ++ E L++ +MQ
Sbjct: 710 EKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 748
Score = 45.8 bits (107), Expect = 3e-04
Identities = 28/151 (18%), Positives = 77/151 (50%), Gaps = 3/151 (1%)
Query: 1109 QYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQE---QQMQKL 1165
Q E+ E+ E+ ++ + K E++I + +E+++ ++ E E ++ QE Q+ ++
Sbjct: 589 QEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEK 648
Query: 1166 LLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDA 1225
+ E + ++ + EE+++ Q+E Q + I + + E+ +K + + + + ++K+ +
Sbjct: 649 MGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQ 708
Query: 1226 QEKRIVSLDSANTRLMSALTQVKERYSMQVR 1256
+EK + + Q ++ + +VR
Sbjct: 709 EEKMCEQEEKMQEQEEKMRRQEEKMWEQEVR 739
Score = 43.5 bits (101), Expect = 0.001
Identities = 26/118 (22%), Positives = 63/118 (53%), Gaps = 5/118 (4%)
Query: 1111 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYK 1170
EE + E E+ +E K E+ E ++ + +E++R ++ E ++ QE++ Q E +
Sbjct: 550 EEKMHEQEKIWEEEKRQEQ-EDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQ----EQE 604
Query: 1171 ARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEK 1228
++ EE++R Q+E+ Q + I + + E+ + + + + + ++K+ + +EK
Sbjct: 605 EKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEK 662
Score = 41.6 bits (96), Expect = 0.005
Identities = 27/129 (20%), Positives = 71/129 (55%), Gaps = 11/129 (8%)
Query: 1109 QYEEDVEETEQNLDEAKHA-EKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLL 1167
+ EE V E+ + E + ++ E+++ K +E++R +++E E ++ QE++++
Sbjct: 581 EQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIR---- 636
Query: 1168 EYKARLEDSEERLRRQQE---EKDSQMKSIISRLMAVEEELK---KDHAEMQAVIDAKQK 1221
E + ++ EE++ Q+E E++ +M+ + EE+++ K E + I +++
Sbjct: 637 EQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEE 696
Query: 1222 IIDAQEKRI 1230
++ QE+++
Sbjct: 697 MMQEQEEKM 705
Score = 38.9 bits (89), Expect = 0.032
Identities = 28/174 (16%), Positives = 81/174 (46%), Gaps = 3/174 (1%)
Query: 1058 RSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEET 1117
R +++ +E + + I+ ++ +Q Q + E+ W +E++ +
Sbjct: 447 REQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIR 506
Query: 1118 EQNLDEAKHAEKY---EQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLE 1174
+Q + EK E++I + +E++ ++ E E +E+ ++ + + + +
Sbjct: 507 KQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQ 566
Query: 1175 DSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEK 1228
+ E+++ RQ+E+ Q + + + + E+ +K + + + ++KI + +EK
Sbjct: 567 EQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEK 620
Score = 38.5 bits (88), Expect = 0.042
Identities = 22/97 (22%), Positives = 50/97 (51%)
Query: 1111 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYK 1170
EE + E E+ + E + ++E +E++R +R E+ E ++ Q+ + K
Sbjct: 436 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQK 495
Query: 1171 ARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKK 1207
++ + EE++R+Q+E+ Q + I + + E+ +K
Sbjct: 496 EKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEK 532
Score = 37.4 bits (85), Expect = 0.093
Identities = 23/123 (18%), Positives = 65/123 (52%), Gaps = 12/123 (9%)
Query: 1109 QYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLE 1168
+ EE + E E+ + + + ++E+ + +E++ + EE +R Q+ + +
Sbjct: 521 EQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKR------QEQEDKMWR 574
Query: 1169 YKARLEDSEERLRRQQE---EKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDA 1225
+ ++ + EE++ RQ+E E++ + + ++ EE++++ ++Q + ++KI +
Sbjct: 575 QEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQ---EQEEKIREQ 631
Query: 1226 QEK 1228
+EK
Sbjct: 632 EEK 634
Score = 36.2 bits (82), Expect = 0.21
Identities = 37/185 (20%), Positives = 81/185 (43%), Gaps = 9/185 (4%)
Query: 1051 EPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNG-- 1108
E +Q Q+ K+R + + +Q + + + W
Sbjct: 307 EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 366
Query: 1109 QYEEDVEETEQNL--DEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLL 1166
+ EE + E E+ + E EK E++I +L+E++ + E+ E+R ++ + Q+
Sbjct: 367 RQEEMMWEKEEKMRRQEEMMWEK-EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR 425
Query: 1167 LEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELK----KDHAEMQAVIDAKQKI 1222
E +A++ EE++R Q+E+ Q K + + + E+ K + E + + ++KI
Sbjct: 426 QEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKI 485
Query: 1223 IDAQE 1227
+ +E
Sbjct: 486 HEQEE 490
Score = 35.4 bits (80), Expect = 0.35
Identities = 24/137 (17%), Positives = 66/137 (48%), Gaps = 20/137 (14%)
Query: 1111 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQM--QKLLLE 1168
+E+ + E+ + E + ++ E ++ + +E++R ++ E E+++ QE+++ Q+ + E
Sbjct: 409 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIRE 468
Query: 1169 YKARLEDSE------------------ERLRRQQEEKDSQMKSIISRLMAVEEELKKDHA 1210
+ R E E E++ Q+E+ Q + + + + E+ +K
Sbjct: 469 EEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIRE 528
Query: 1211 EMQAVIDAKQKIIDAQE 1227
+ + + ++KI + +E
Sbjct: 529 QEEKMWRQEEKIREQEE 545
Score = 34.7 bits (78), Expect = 0.60
Identities = 31/158 (19%), Positives = 75/158 (47%), Gaps = 29/158 (18%)
Query: 1098 ERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEIT-KLKERLRVSSRRLEEYERRLL 1156
E+ W + EE + E E+ + E + + ++E+ + +E++R + E E ++
Sbjct: 307 EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 366
Query: 1157 VQEQQM----------QKLLLEYKARLEDSEERL-----------RRQQEEK---DSQMK 1192
QE+ M ++++ E + ++ + EE++ +RQ+EEK + +
Sbjct: 367 RQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQ 426
Query: 1193 SIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRI 1230
+++ EE+++ E + I ++K + QE++I
Sbjct: 427 EQEAKMWRQEEKIR----EQEEKIREQEKKMWRQEEKI 460
Score = 33.1 bits (74), Expect = 1.7
Identities = 30/129 (23%), Positives = 65/129 (50%), Gaps = 21/129 (16%)
Query: 1113 DVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQ--------- 1163
D E E+N + + E E ++++ ++ R+LE +LL+ +QQ+Q
Sbjct: 216 DEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLER--AKLLLPQQQLQAEADHLGKE 273
Query: 1164 --KLLLEYKARLEDSE--ERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAK 1219
+ + +A++E++E RL +QQEEK + + ++E +K + + + + +
Sbjct: 274 LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEE------KIQEWEEKIQEQEEKIREQE 327
Query: 1220 QKIIDAQEK 1228
+KI + +EK
Sbjct: 328 EKIREQEEK 336
Score = 31.2 bits (69), Expect = 6.6
Identities = 32/120 (26%), Positives = 60/120 (50%), Gaps = 14/120 (11%)
Query: 1116 ETEQNLD----EAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKA 1171
E EQ L + K A++Y +E+TK ++ L LE Y + +E + + L+ K
Sbjct: 176 ELEQALSAVATQKKKADRYIEELTKERDAL-----SLELYRNTITDEELKEKNAKLQEKL 230
Query: 1172 RLEDSEERLRRQQEEKDSQMKSIISRLMAVEEEL--KKDH--AEMQAVIDAKQKIIDAQE 1227
+L +S E+ Q K+ + K ++L+ +++L + DH E+Q+V Q ++ E
Sbjct: 231 QLVES-EKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENE 289
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 54.3 bits (129), Expect = 7e-07
Identities = 42/149 (28%), Positives = 83/149 (55%), Gaps = 18/149 (12%)
Query: 1111 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSR---RLEEYERRLLVQEQQMQKLLL 1167
E +++E EQ KH++ E++ L+E+L+ + EE RL ++Q+++++L
Sbjct: 872 ENELKELEQ-----KHSQLTEEK-NLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 925
Query: 1168 EYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAV----IDAKQKII 1223
E +ARLE+ E+R ++ Q E+ K + +++ +EE+L+++ A Q + + A+ K I
Sbjct: 926 EMEARLEEEEDRGQQLQAER----KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK-I 980
Query: 1224 DAQEKRIVSLDSANTRLMSALTQVKERYS 1252
E I+ +D N +L ++ER S
Sbjct: 981 KKLEDEILVMDDQNNKLSKERKLLEERIS 1009
Score = 39.3 bits (90), Expect = 0.024
Identities = 44/201 (21%), Positives = 90/201 (44%), Gaps = 15/201 (7%)
Query: 1062 QSSSSRESPVPKVRAIQRQQTQQVQSPVDSAT--MSPVE----RTAAWVLNNGQYEEDV- 1114
Q S+ S + RA + ++Q+ V+S T ++ E + A V + +D
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321
Query: 1115 ----EETEQNLDEAKHAEKYEQEITKLKERL---RVSSRRLEEYERRLLVQEQQMQKLLL 1167
EET Q L+ + + E+E L+++L + + LE + L +Q +K L
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381
Query: 1168 EYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQE 1227
++ + +E EE +R Q+E ++ + + A ++L+K +Q +D +D Q
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEK-AAAYDKLEKTKNRLQQELDDLVVDLDNQR 1440
Query: 1228 KRIVSLDSANTRLMSALTQVK 1248
+ + +L+ + L + K
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEK 1461
Score = 39.3 bits (90), Expect = 0.024
Identities = 61/253 (24%), Positives = 106/253 (41%), Gaps = 46/253 (18%)
Query: 1067 RESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQ---YEEDVEETEQNLDE 1123
RE + ++R +Q Q + Q ++ A S E A N + E D+ + +++L
Sbjct: 1640 REEAIKQLRKLQAQM-KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698
Query: 1124 AKHAEKY-EQEITKLKERLRVS---SRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEER 1179
A+ A K + E +L E L S L++ +RRL + Q+++ L E + +E +R
Sbjct: 1699 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1758
Query: 1180 LRR--QQEEK----------------------DSQMKSIISRLMAVEEELKKDHAEMQAV 1215
+R+ QQ E+ + Q K + S+L +E +K A
Sbjct: 1759 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818
Query: 1216 IDAK------QKIIDAQEKRIV--SLDSANTRLMSALTQVK------ERYSMQVRNGISP 1261
++AK Q +A+EK+ SL + +L L QV+ E+Y Q G +
Sbjct: 1819 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR 1878
Query: 1262 TNPTKLSITENGE 1274
K + E E
Sbjct: 1879 VKQLKRQLEEAEE 1891
Score = 37.0 bits (84), Expect = 0.12
Identities = 29/144 (20%), Positives = 64/144 (44%), Gaps = 1/144 (0%)
Query: 1107 NGQYEEDVEETEQNLDEA-KHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKL 1165
N + ++E+ + D+ K+ + E+ L+ ++ +LEE E L E +L
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565
Query: 1166 LLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDA 1225
+ +A E L+ + E+ + + + + +L E EL+ + + AK+K+
Sbjct: 1566 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1625
Query: 1226 QEKRIVSLDSANTRLMSALTQVKE 1249
+ + DSA A+ Q+++
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRK 1649
Score = 36.2 bits (82), Expect = 0.21
Identities = 27/115 (23%), Positives = 61/115 (53%), Gaps = 6/115 (5%)
Query: 1115 EETEQNLDEAKHAEKYEQEITKLKERLR---VSSRRLEEYERRLLVQEQQMQKLLLEYKA 1171
EE +NL + K+ K+E I++L+ RL+ S + LE+ +R+L + + + +A
Sbjct: 1019 EEKAKNLTKLKN--KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 1172 RLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQ 1226
++ + + +L +++EE + + + + LKK E++ I Q+ +D++
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR-ELEGHISDLQEDLDSE 1130
Score = 34.3 bits (77), Expect = 0.78
Identities = 29/121 (23%), Positives = 57/121 (47%), Gaps = 11/121 (9%)
Query: 1109 QYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLE 1168
++E + E E L K EK QE+ KLK +L + E L Q +++ L +
Sbjct: 1031 KHESMISELEVRL---KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1087
Query: 1169 YKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEK 1228
+ L+ + RL + +K++ +K I EL+ +++Q +D+++ + EK
Sbjct: 1088 KEEELQAALARLDDEIAQKNNALKKI--------RELEGHISDLQEDLDSERAARNKAEK 1139
Query: 1229 R 1229
+
Sbjct: 1140 Q 1140
Score = 32.7 bits (73), Expect = 2.3
Identities = 28/147 (19%), Positives = 67/147 (45%), Gaps = 2/147 (1%)
Query: 1112 EDVEETEQNLDEAKHAEKYEQEI-TKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYK 1170
E++E + L++ + +QE+ K ++ + V + L+E R Q Q+M++ +
Sbjct: 1146 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1205
Query: 1171 ARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRI 1230
L + E+ +R + D +++ + EL+ + + ++ K+K ++AQ + +
Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV-LGQAKQEVEHKKKKLEAQVQEL 1264
Query: 1231 VSLDSANTRLMSALTQVKERYSMQVRN 1257
S S R + L + +V +
Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVES 1291
Score = 32.0 bits (71), Expect = 3.9
Identities = 34/172 (19%), Positives = 67/172 (38%), Gaps = 40/172 (23%)
Query: 1058 RSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEET 1117
RS Q + S + + R + +++ V S S + A + Q EE VE+
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI---AQLEEQVEQE 1833
Query: 1118 EQNL----------------------DEAKHAEKYEQEITKLKERLRVSSRRLEEYERRL 1155
+ DE K AE+Y+++ K R++ R+LEE E
Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAE--- 1890
Query: 1156 LVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKK 1207
E R+ + +L+R+ +E +++ + A++ +L++
Sbjct: 1891 ------------EESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930
Score = 31.6 bits (70), Expect = 5.1
Identities = 28/120 (23%), Positives = 54/120 (45%), Gaps = 7/120 (5%)
Query: 1115 EETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLE 1174
+E Q + K + E I+ L+E L + E+ Q++ + + L K LE
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK----QKRDLGEELEALKTELE 1156
Query: 1175 DSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLD 1234
D+ + QQE + + + + A++EE + A++Q + +QK A E+ L+
Sbjct: 1157 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ---EMRQKHAQAVEELTEQLE 1213
Score = 31.6 bits (70), Expect = 5.1
Identities = 35/153 (22%), Positives = 72/153 (47%), Gaps = 33/153 (21%)
Query: 1109 QYEEDVEETEQNLDE-AKHAEKYEQEITKLKERL---RVSSRRLEEYERRLLVQEQQMQK 1164
Q EE++EE + N++ + K Q+ +L L R ++++ E ++L Q ++++
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799
Query: 1165 LLLEYK---------------ARLEDSEERLRRQQEEKDSQMKSIISR-------LMAVE 1202
L E + A++ EE++ ++ EK + KS+ + L+ VE
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1859
Query: 1203 EELK-----KDHAEM--QAVIDAKQKIIDAQEK 1228
+E K K+ AE V K+++ +A+E+
Sbjct: 1860 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 54.3 bits (129), Expect = 7e-07
Identities = 42/149 (28%), Positives = 83/149 (55%), Gaps = 18/149 (12%)
Query: 1111 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSR---RLEEYERRLLVQEQQMQKLLL 1167
E +++E EQ KH++ E++ L+E+L+ + EE RL ++Q+++++L
Sbjct: 879 ENELKELEQ-----KHSQLTEEK-NLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 932
Query: 1168 EYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAV----IDAKQKII 1223
E +ARLE+ E+R ++ Q E+ K + +++ +EE+L+++ A Q + + A+ K I
Sbjct: 933 EMEARLEEEEDRGQQLQAER----KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK-I 987
Query: 1224 DAQEKRIVSLDSANTRLMSALTQVKERYS 1252
E I+ +D N +L ++ER S
Sbjct: 988 KKLEDEILVMDDQNNKLSKERKLLEERIS 1016
Score = 39.3 bits (90), Expect = 0.024
Identities = 44/201 (21%), Positives = 90/201 (44%), Gaps = 15/201 (7%)
Query: 1062 QSSSSRESPVPKVRAIQRQQTQQVQSPVDSAT--MSPVE----RTAAWVLNNGQYEEDV- 1114
Q S+ S + RA + ++Q+ V+S T ++ E + A V + +D
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328
Query: 1115 ----EETEQNLDEAKHAEKYEQEITKLKERL---RVSSRRLEEYERRLLVQEQQMQKLLL 1167
EET Q L+ + + E+E L+++L + + LE + L +Q +K L
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388
Query: 1168 EYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQE 1227
++ + +E EE +R Q+E ++ + + A ++L+K +Q +D +D Q
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEK-AAAYDKLEKTKNRLQQELDDLVVDLDNQR 1447
Query: 1228 KRIVSLDSANTRLMSALTQVK 1248
+ + +L+ + L + K
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEK 1468
Score = 39.3 bits (90), Expect = 0.024
Identities = 61/253 (24%), Positives = 106/253 (41%), Gaps = 46/253 (18%)
Query: 1067 RESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQ---YEEDVEETEQNLDE 1123
RE + ++R +Q Q + Q ++ A S E A N + E D+ + +++L
Sbjct: 1647 REEAIKQLRKLQAQM-KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705
Query: 1124 AKHAEKY-EQEITKLKERLRVS---SRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEER 1179
A+ A K + E +L E L S L++ +RRL + Q+++ L E + +E +R
Sbjct: 1706 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1765
Query: 1180 LRR--QQEEK----------------------DSQMKSIISRLMAVEEELKKDHAEMQAV 1215
+R+ QQ E+ + Q K + S+L +E +K A
Sbjct: 1766 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825
Query: 1216 IDAK------QKIIDAQEKRIV--SLDSANTRLMSALTQVK------ERYSMQVRNGISP 1261
++AK Q +A+EK+ SL + +L L QV+ E+Y Q G +
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR 1885
Query: 1262 TNPTKLSITENGE 1274
K + E E
Sbjct: 1886 VKQLKRQLEEAEE 1898
Score = 37.0 bits (84), Expect = 0.12
Identities = 29/144 (20%), Positives = 64/144 (44%), Gaps = 1/144 (0%)
Query: 1107 NGQYEEDVEETEQNLDEA-KHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKL 1165
N + ++E+ + D+ K+ + E+ L+ ++ +LEE E L E +L
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572
Query: 1166 LLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDA 1225
+ +A E L+ + E+ + + + + +L E EL+ + + AK+K+
Sbjct: 1573 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1632
Query: 1226 QEKRIVSLDSANTRLMSALTQVKE 1249
+ + DSA A+ Q+++
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRK 1656
Score = 36.2 bits (82), Expect = 0.21
Identities = 27/115 (23%), Positives = 61/115 (53%), Gaps = 6/115 (5%)
Query: 1115 EETEQNLDEAKHAEKYEQEITKLKERLR---VSSRRLEEYERRLLVQEQQMQKLLLEYKA 1171
EE +NL + K+ K+E I++L+ RL+ S + LE+ +R+L + + + +A
Sbjct: 1026 EEKAKNLTKLKN--KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 1172 RLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQ 1226
++ + + +L +++EE + + + + LKK E++ I Q+ +D++
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR-ELEGHISDLQEDLDSE 1137
Score = 34.3 bits (77), Expect = 0.78
Identities = 29/121 (23%), Positives = 57/121 (47%), Gaps = 11/121 (9%)
Query: 1109 QYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLE 1168
++E + E E L K EK QE+ KLK +L + E L Q +++ L +
Sbjct: 1038 KHESMISELEVRL---KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1094
Query: 1169 YKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEK 1228
+ L+ + RL + +K++ +K I EL+ +++Q +D+++ + EK
Sbjct: 1095 KEEELQAALARLDDEIAQKNNALKKI--------RELEGHISDLQEDLDSERAARNKAEK 1146
Query: 1229 R 1229
+
Sbjct: 1147 Q 1147
Score = 32.7 bits (73), Expect = 2.3
Identities = 28/147 (19%), Positives = 67/147 (45%), Gaps = 2/147 (1%)
Query: 1112 EDVEETEQNLDEAKHAEKYEQEI-TKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYK 1170
E++E + L++ + +QE+ K ++ + V + L+E R Q Q+M++ +
Sbjct: 1153 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1212
Query: 1171 ARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRI 1230
L + E+ +R + D +++ + EL+ + + ++ K+K ++AQ + +
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV-LGQAKQEVEHKKKKLEAQVQEL 1271
Query: 1231 VSLDSANTRLMSALTQVKERYSMQVRN 1257
S S R + L + +V +
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVES 1298
Score = 32.0 bits (71), Expect = 3.9
Identities = 34/172 (19%), Positives = 67/172 (38%), Gaps = 40/172 (23%)
Query: 1058 RSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEET 1117
RS Q + S + + R + +++ V S S + A + Q EE VE+
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI---AQLEEQVEQE 1840
Query: 1118 EQNL----------------------DEAKHAEKYEQEITKLKERLRVSSRRLEEYERRL 1155
+ DE K AE+Y+++ K R++ R+LEE E
Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAE--- 1897
Query: 1156 LVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKK 1207
E R+ + +L+R+ +E +++ + A++ +L++
Sbjct: 1898 ------------EESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937
Score = 31.6 bits (70), Expect = 5.1
Identities = 28/120 (23%), Positives = 54/120 (45%), Gaps = 7/120 (5%)
Query: 1115 EETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLE 1174
+E Q + K + E I+ L+E L + E+ Q++ + + L K LE
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK----QKRDLGEELEALKTELE 1163
Query: 1175 DSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLD 1234
D+ + QQE + + + + A++EE + A++Q + +QK A E+ L+
Sbjct: 1164 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ---EMRQKHAQAVEELTEQLE 1220
Score = 31.6 bits (70), Expect = 5.1
Identities = 35/153 (22%), Positives = 72/153 (47%), Gaps = 33/153 (21%)
Query: 1109 QYEEDVEETEQNLDE-AKHAEKYEQEITKLKERL---RVSSRRLEEYERRLLVQEQQMQK 1164
Q EE++EE + N++ + K Q+ +L L R ++++ E ++L Q ++++
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806
Query: 1165 LLLEYK---------------ARLEDSEERLRRQQEEKDSQMKSIISR-------LMAVE 1202
L E + A++ EE++ ++ EK + KS+ + L+ VE
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1866
Query: 1203 EELK-----KDHAEM--QAVIDAKQKIIDAQEK 1228
+E K K+ AE V K+++ +A+E+
Sbjct: 1867 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 54.3 bits (129), Expect = 7e-07
Identities = 42/149 (28%), Positives = 83/149 (55%), Gaps = 18/149 (12%)
Query: 1111 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSR---RLEEYERRLLVQEQQMQKLLL 1167
E +++E EQ KH++ E++ L+E+L+ + EE RL ++Q+++++L
Sbjct: 879 ENELKELEQ-----KHSQLTEEK-NLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 932
Query: 1168 EYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAV----IDAKQKII 1223
E +ARLE+ E+R ++ Q E+ K + +++ +EE+L+++ A Q + + A+ K I
Sbjct: 933 EMEARLEEEEDRGQQLQAER----KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK-I 987
Query: 1224 DAQEKRIVSLDSANTRLMSALTQVKERYS 1252
E I+ +D N +L ++ER S
Sbjct: 988 KKLEDEILVMDDQNNKLSKERKLLEERIS 1016
Score = 39.3 bits (90), Expect = 0.024
Identities = 44/201 (21%), Positives = 90/201 (44%), Gaps = 15/201 (7%)
Query: 1062 QSSSSRESPVPKVRAIQRQQTQQVQSPVDSAT--MSPVE----RTAAWVLNNGQYEEDV- 1114
Q S+ S + RA + ++Q+ V+S T ++ E + A V + +D
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328
Query: 1115 ----EETEQNLDEAKHAEKYEQEITKLKERL---RVSSRRLEEYERRLLVQEQQMQKLLL 1167
EET Q L+ + + E+E L+++L + + LE + L +Q +K L
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388
Query: 1168 EYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQE 1227
++ + +E EE +R Q+E ++ + + A ++L+K +Q +D +D Q
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEK-AAAYDKLEKTKNRLQQELDDLVVDLDNQR 1447
Query: 1228 KRIVSLDSANTRLMSALTQVK 1248
+ + +L+ + L + K
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEK 1468
Score = 39.3 bits (90), Expect = 0.024
Identities = 61/253 (24%), Positives = 106/253 (41%), Gaps = 46/253 (18%)
Query: 1067 RESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQ---YEEDVEETEQNLDE 1123
RE + ++R +Q Q + Q ++ A S E A N + E D+ + +++L
Sbjct: 1647 REEAIKQLRKLQAQM-KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705
Query: 1124 AKHAEKY-EQEITKLKERLRVS---SRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEER 1179
A+ A K + E +L E L S L++ +RRL + Q+++ L E + +E +R
Sbjct: 1706 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1765
Query: 1180 LRR--QQEEK----------------------DSQMKSIISRLMAVEEELKKDHAEMQAV 1215
+R+ QQ E+ + Q K + S+L +E +K A
Sbjct: 1766 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825
Query: 1216 IDAK------QKIIDAQEKRIV--SLDSANTRLMSALTQVK------ERYSMQVRNGISP 1261
++AK Q +A+EK+ SL + +L L QV+ E+Y Q G +
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR 1885
Query: 1262 TNPTKLSITENGE 1274
K + E E
Sbjct: 1886 VKQLKRQLEEAEE 1898
Score = 37.0 bits (84), Expect = 0.12
Identities = 29/144 (20%), Positives = 64/144 (44%), Gaps = 1/144 (0%)
Query: 1107 NGQYEEDVEETEQNLDEA-KHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKL 1165
N + ++E+ + D+ K+ + E+ L+ ++ +LEE E L E +L
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572
Query: 1166 LLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDA 1225
+ +A E L+ + E+ + + + + +L E EL+ + + AK+K+
Sbjct: 1573 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1632
Query: 1226 QEKRIVSLDSANTRLMSALTQVKE 1249
+ + DSA A+ Q+++
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRK 1656
Score = 36.2 bits (82), Expect = 0.21
Identities = 27/115 (23%), Positives = 61/115 (53%), Gaps = 6/115 (5%)
Query: 1115 EETEQNLDEAKHAEKYEQEITKLKERLR---VSSRRLEEYERRLLVQEQQMQKLLLEYKA 1171
EE +NL + K+ K+E I++L+ RL+ S + LE+ +R+L + + + +A
Sbjct: 1026 EEKAKNLTKLKN--KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 1172 RLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQ 1226
++ + + +L +++EE + + + + LKK E++ I Q+ +D++
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR-ELEGHISDLQEDLDSE 1137
Score = 34.3 bits (77), Expect = 0.78
Identities = 29/121 (23%), Positives = 57/121 (47%), Gaps = 11/121 (9%)
Query: 1109 QYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLE 1168
++E + E E L K EK QE+ KLK +L + E L Q +++ L +
Sbjct: 1038 KHESMISELEVRL---KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1094
Query: 1169 YKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEK 1228
+ L+ + RL + +K++ +K I EL+ +++Q +D+++ + EK
Sbjct: 1095 KEEELQAALARLDDEIAQKNNALKKI--------RELEGHISDLQEDLDSERAARNKAEK 1146
Query: 1229 R 1229
+
Sbjct: 1147 Q 1147
Score = 32.7 bits (73), Expect = 2.3
Identities = 28/147 (19%), Positives = 67/147 (45%), Gaps = 2/147 (1%)
Query: 1112 EDVEETEQNLDEAKHAEKYEQEI-TKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYK 1170
E++E + L++ + +QE+ K ++ + V + L+E R Q Q+M++ +
Sbjct: 1153 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1212
Query: 1171 ARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRI 1230
L + E+ +R + D +++ + EL+ + + ++ K+K ++AQ + +
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV-LGQAKQEVEHKKKKLEAQVQEL 1271
Query: 1231 VSLDSANTRLMSALTQVKERYSMQVRN 1257
S S R + L + +V +
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVES 1298
Score = 31.6 bits (70), Expect = 5.1
Identities = 28/120 (23%), Positives = 54/120 (45%), Gaps = 7/120 (5%)
Query: 1115 EETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLE 1174
+E Q + K + E I+ L+E L + E+ Q++ + + L K LE
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK----QKRDLGEELEALKTELE 1163
Query: 1175 DSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLD 1234
D+ + QQE + + + + A++EE + A++Q + +QK A E+ L+
Sbjct: 1164 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ---EMRQKHAQAVEELTEQLE 1220
Score = 31.6 bits (70), Expect = 5.1
Identities = 35/153 (22%), Positives = 72/153 (47%), Gaps = 33/153 (21%)
Query: 1109 QYEEDVEETEQNLDE-AKHAEKYEQEITKLKERL---RVSSRRLEEYERRLLVQEQQMQK 1164
Q EE++EE + N++ + K Q+ +L L R ++++ E ++L Q ++++
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806
Query: 1165 LLLEYK---------------ARLEDSEERLRRQQEEKDSQMKSIISR-------LMAVE 1202
L E + A++ EE++ ++ EK + KS+ + L+ VE
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1866
Query: 1203 EELK-----KDHAEM--QAVIDAKQKIIDAQEK 1228
+E K K+ AE V K+++ +A+E+
Sbjct: 1867 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899
Score = 31.2 bits (69), Expect = 6.6
Identities = 35/160 (21%), Positives = 65/160 (40%), Gaps = 32/160 (20%)
Query: 1058 RSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEET 1117
RS Q + S + + R + +++ V S S + A + Q EE VE+
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI---AQLEEQVEQE 1840
Query: 1118 EQNL----------------------DEAKHAEKYEQEITKLKERLRVSSRRLEEYE--- 1152
+ DE K AE+Y+++ K R++ R+LEE E
Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900
Query: 1153 RRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMK 1192
+R+ +++Q+ L E +S E + R+ S+++
Sbjct: 1901 QRINANRRKLQRELDE----ATESNEAMGREVNALKSKLR 1936
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 54.3 bits (129), Expect = 7e-07
Identities = 42/149 (28%), Positives = 83/149 (55%), Gaps = 18/149 (12%)
Query: 1111 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSR---RLEEYERRLLVQEQQMQKLLL 1167
E +++E EQ KH++ E++ L+E+L+ + EE RL ++Q+++++L
Sbjct: 872 ENELKELEQ-----KHSQLTEEK-NLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 925
Query: 1168 EYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAV----IDAKQKII 1223
E +ARLE+ E+R ++ Q E+ K + +++ +EE+L+++ A Q + + A+ K I
Sbjct: 926 EMEARLEEEEDRGQQLQAER----KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK-I 980
Query: 1224 DAQEKRIVSLDSANTRLMSALTQVKERYS 1252
E I+ +D N +L ++ER S
Sbjct: 981 KKLEDEILVMDDQNNKLSKERKLLEERIS 1009
Score = 39.3 bits (90), Expect = 0.024
Identities = 44/201 (21%), Positives = 90/201 (44%), Gaps = 15/201 (7%)
Query: 1062 QSSSSRESPVPKVRAIQRQQTQQVQSPVDSAT--MSPVE----RTAAWVLNNGQYEEDV- 1114
Q S+ S + RA + ++Q+ V+S T ++ E + A V + +D
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321
Query: 1115 ----EETEQNLDEAKHAEKYEQEITKLKERL---RVSSRRLEEYERRLLVQEQQMQKLLL 1167
EET Q L+ + + E+E L+++L + + LE + L +Q +K L
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381
Query: 1168 EYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQE 1227
++ + +E EE +R Q+E ++ + + A ++L+K +Q +D +D Q
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEK-AAAYDKLEKTKNRLQQELDDLVVDLDNQR 1440
Query: 1228 KRIVSLDSANTRLMSALTQVK 1248
+ + +L+ + L + K
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEK 1461
Score = 39.3 bits (90), Expect = 0.024
Identities = 61/253 (24%), Positives = 106/253 (41%), Gaps = 46/253 (18%)
Query: 1067 RESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQ---YEEDVEETEQNLDE 1123
RE + ++R +Q Q + Q ++ A S E A N + E D+ + +++L
Sbjct: 1640 REEAIKQLRKLQAQM-KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698
Query: 1124 AKHAEKY-EQEITKLKERLRVS---SRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEER 1179
A+ A K + E +L E L S L++ +RRL + Q+++ L E + +E +R
Sbjct: 1699 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1758
Query: 1180 LRR--QQEEK----------------------DSQMKSIISRLMAVEEELKKDHAEMQAV 1215
+R+ QQ E+ + Q K + S+L +E +K A
Sbjct: 1759 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818
Query: 1216 IDAK------QKIIDAQEKRIV--SLDSANTRLMSALTQVK------ERYSMQVRNGISP 1261
++AK Q +A+EK+ SL + +L L QV+ E+Y Q G +
Sbjct: 1819 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR 1878
Query: 1262 TNPTKLSITENGE 1274
K + E E
Sbjct: 1879 VKQLKRQLEEAEE 1891
Score = 37.0 bits (84), Expect = 0.12
Identities = 29/144 (20%), Positives = 64/144 (44%), Gaps = 1/144 (0%)
Query: 1107 NGQYEEDVEETEQNLDEA-KHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKL 1165
N + ++E+ + D+ K+ + E+ L+ ++ +LEE E L E +L
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565
Query: 1166 LLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDA 1225
+ +A E L+ + E+ + + + + +L E EL+ + + AK+K+
Sbjct: 1566 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1625
Query: 1226 QEKRIVSLDSANTRLMSALTQVKE 1249
+ + DSA A+ Q+++
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRK 1649
Score = 36.2 bits (82), Expect = 0.21
Identities = 27/115 (23%), Positives = 61/115 (53%), Gaps = 6/115 (5%)
Query: 1115 EETEQNLDEAKHAEKYEQEITKLKERLR---VSSRRLEEYERRLLVQEQQMQKLLLEYKA 1171
EE +NL + K+ K+E I++L+ RL+ S + LE+ +R+L + + + +A
Sbjct: 1019 EEKAKNLTKLKN--KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 1172 RLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQ 1226
++ + + +L +++EE + + + + LKK E++ I Q+ +D++
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR-ELEGHISDLQEDLDSE 1130
Score = 34.3 bits (77), Expect = 0.78
Identities = 29/121 (23%), Positives = 57/121 (47%), Gaps = 11/121 (9%)
Query: 1109 QYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLE 1168
++E + E E L K EK QE+ KLK +L + E L Q +++ L +
Sbjct: 1031 KHESMISELEVRL---KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1087
Query: 1169 YKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEK 1228
+ L+ + RL + +K++ +K I EL+ +++Q +D+++ + EK
Sbjct: 1088 KEEELQAALARLDDEIAQKNNALKKI--------RELEGHISDLQEDLDSERAARNKAEK 1139
Query: 1229 R 1229
+
Sbjct: 1140 Q 1140
Score = 32.7 bits (73), Expect = 2.3
Identities = 28/147 (19%), Positives = 67/147 (45%), Gaps = 2/147 (1%)
Query: 1112 EDVEETEQNLDEAKHAEKYEQEI-TKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYK 1170
E++E + L++ + +QE+ K ++ + V + L+E R Q Q+M++ +
Sbjct: 1146 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1205
Query: 1171 ARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRI 1230
L + E+ +R + D +++ + EL+ + + ++ K+K ++AQ + +
Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV-LGQAKQEVEHKKKKLEAQVQEL 1264
Query: 1231 VSLDSANTRLMSALTQVKERYSMQVRN 1257
S S R + L + +V +
Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVES 1291
Score = 31.6 bits (70), Expect = 5.1
Identities = 28/120 (23%), Positives = 54/120 (45%), Gaps = 7/120 (5%)
Query: 1115 EETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLE 1174
+E Q + K + E I+ L+E L + E+ Q++ + + L K LE
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK----QKRDLGEELEALKTELE 1156
Query: 1175 DSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLD 1234
D+ + QQE + + + + A++EE + A++Q + +QK A E+ L+
Sbjct: 1157 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ---EMRQKHAQAVEELTEQLE 1213
Score = 31.6 bits (70), Expect = 5.1
Identities = 35/153 (22%), Positives = 72/153 (47%), Gaps = 33/153 (21%)
Query: 1109 QYEEDVEETEQNLDE-AKHAEKYEQEITKLKERL---RVSSRRLEEYERRLLVQEQQMQK 1164
Q EE++EE + N++ + K Q+ +L L R ++++ E ++L Q ++++
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799
Query: 1165 LLLEYK---------------ARLEDSEERLRRQQEEKDSQMKSIISR-------LMAVE 1202
L E + A++ EE++ ++ EK + KS+ + L+ VE
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1859
Query: 1203 EELK-----KDHAEM--QAVIDAKQKIIDAQEK 1228
+E K K+ AE V K+++ +A+E+
Sbjct: 1860 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892
Score = 31.2 bits (69), Expect = 6.6
Identities = 35/160 (21%), Positives = 65/160 (40%), Gaps = 32/160 (20%)
Query: 1058 RSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEET 1117
RS Q + S + + R + +++ V S S + A + Q EE VE+
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI---AQLEEQVEQE 1833
Query: 1118 EQNL----------------------DEAKHAEKYEQEITKLKERLRVSSRRLEEYE--- 1152
+ DE K AE+Y+++ K R++ R+LEE E
Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1893
Query: 1153 RRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMK 1192
+R+ +++Q+ L E +S E + R+ S+++
Sbjct: 1894 QRINANRRKLQRELDE----ATESNEAMGREVNALKSKLR 1929
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 53.5 bits (127), Expect = 1e-06
Identities = 41/159 (25%), Positives = 78/159 (49%), Gaps = 6/159 (3%)
Query: 1073 KVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQ 1132
K+ A +Q+ ++ QS ++S+ + YEE +E E E K+ + +
Sbjct: 1451 KILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQ---E 1507
Query: 1133 EITKLKERLRVSSRRLEEYER---RLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDS 1189
EI+ L E+L S + + E E+ +L ++ ++Q L E +A LE E ++ R Q E +
Sbjct: 1508 EISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQ 1567
Query: 1190 QMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEK 1228
I +L +EE+++ V+D+ Q +DA+ +
Sbjct: 1568 IKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETR 1606
Score = 41.6 bits (96), Expect = 0.005
Identities = 40/172 (23%), Positives = 74/172 (43%), Gaps = 11/172 (6%)
Query: 1114 VEETEQNLDEAKHAE-KYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKAR 1172
+EE E+ L+ + A K E+ + L L S RLEE VQ + +K E++
Sbjct: 1115 IEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKM 1174
Query: 1173 LEDSEER----------LRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKI 1222
D EE LR++ + +++ I L V+++L+K+ +E + +D
Sbjct: 1175 RRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSN 1234
Query: 1223 IDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGE 1274
++ K +L+ L + + + + R+ T+ TENGE
Sbjct: 1235 MEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGE 1286
Score = 41.6 bits (96), Expect = 0.005
Identities = 72/350 (20%), Positives = 129/350 (36%), Gaps = 42/350 (12%)
Query: 939 ASIDSSLENLSTASSRSQSNSEDFKLS-GPSNSSMEDFTKRSTQSEDFSRRHTVPDR--- 994
A + ++NL + + +FKL S+ME K E R T+ D+
Sbjct: 1201 AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCR--TLEDQMNE 1258
Query: 995 HIPLALPRQNS----TGQAQIRKVDQGGLGARAKAPPSLPHSAS---LRSTGSMSVVSAA 1047
H A Q S T Q + + G L + +L + L T + +
Sbjct: 1259 HRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQ 1318
Query: 1048 LVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQ-QVQSPVDSATMSPVERTAAWVLN 1106
L E + + S+ + + + + + + + ++Q + A + + +
Sbjct: 1319 LEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETD 1378
Query: 1107 NGQYEEDVEETE----QNLDEAKHA-----------EKYEQEITKLKERLRVSSRRLEEY 1151
Q E++EE + Q L EA+ A EK + + E L V R
Sbjct: 1379 AIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAA 1438
Query: 1152 ERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEEL------ 1205
L +++ K+L E+K + E+S+ L Q+E S + A EE L
Sbjct: 1439 AAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETF 1498
Query: 1206 KKDHAEMQAVID-------AKQKIIDAQEKRIVSLDSANTRLMSALTQVK 1248
K+++ +Q I + K I EK L++ L SAL + +
Sbjct: 1499 KRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAE 1548
Score = 38.5 bits (88), Expect = 0.042
Identities = 41/207 (19%), Positives = 97/207 (46%), Gaps = 33/207 (15%)
Query: 1051 EPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQY 1110
+P+ + ++ +S +E A+++ + ++ + E+ + +
Sbjct: 837 KPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELE---------EKMVSLLQEKNDL 887
Query: 1111 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYK 1170
+ V+ + NL +A+ E+ +Q I K ++++ ++ E ER L E++M L K
Sbjct: 888 QLQVQAEQDNLADAE--ERCDQLI---KNKIQLEAKVKEMNER--LEDEEEMNAELTAKK 940
Query: 1171 ARLEDSEERLRRQ-----------QEEK---DSQMKSIISRLMAVEEELKKDHAEMQAVI 1216
+LED L+R ++EK ++++K++ + ++E + K E +A+
Sbjct: 941 RKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1000
Query: 1217 DAKQKIID---AQEKRIVSLDSANTRL 1240
+A Q+ +D A+E ++ +L A +L
Sbjct: 1001 EAHQQALDDLQAEEDKVNTLTKAKVKL 1027
Score = 36.6 bits (83), Expect = 0.16
Identities = 42/203 (20%), Positives = 91/203 (44%), Gaps = 10/203 (4%)
Query: 1059 SRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQ--YEEDVEE 1116
+ QQ+ ++ KV + + + + Q D E+ L + E D++
Sbjct: 1002 AHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKL 1061
Query: 1117 TEQNLDEAKHAEKYEQEITKLKE-RLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLED 1175
T++++ + ++ ++ E K K+ L + R+E+ + Q+QK L E +AR+E+
Sbjct: 1062 TQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQ----ALGSQLQKKLKELQARIEE 1117
Query: 1176 SEERL--RRQQEEKDSQMKSIISR-LMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVS 1232
EE L R K +++S +SR L + E L++ I+ +K +K
Sbjct: 1118 LEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRD 1177
Query: 1233 LDSANTRLMSALTQVKERYSMQV 1255
L+ A + + ++++++ V
Sbjct: 1178 LEEATLQHEATAAALRKKHADSV 1200
Score = 35.0 bits (79), Expect = 0.46
Identities = 94/510 (18%), Positives = 195/510 (38%), Gaps = 71/510 (13%)
Query: 733 SQLDKATVAKLGPLPRVLADITKSLTNPTPIQQQLRRF---------------TEHNSSP 777
S L+K + ++ D+ +S + ++ R F +E SS
Sbjct: 1412 SSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ 1471
Query: 778 NVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFR-----------GKTLLLVQQAS 826
+ SLS+ L K+ ++ + L L++ ++N + GKT+ +++
Sbjct: 1472 KEARSLSTELFKL-KNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVR 1530
Query: 827 SQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVAS 886
Q +EK E +S+L + + AQ+E + ++ +L + Q A
Sbjct: 1531 KQ--LEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ-AK 1587
Query: 887 IKQLRETQSTPQSAPQVRRPLHPALN----QPGGLQPLSFQNPVYHLNNPIPAMPKA--S 940
LR S S R + AL G L + Q + H N K S
Sbjct: 1588 RNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQ--LSHANRMAAEAQKQVKS 1645
Query: 941 IDSSLENLSTASSRSQSNSEDFK-----------LSGPSNSSMEDFTKRSTQSEDFSRRH 989
+ S L++ + ++D K L + +++ +S + +
Sbjct: 1646 LQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQE 1705
Query: 990 TVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALV 1049
+ L QN++ Q +K+D + + ++ + ++ AA++
Sbjct: 1706 LIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMM 1765
Query: 1050 AEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQ 1109
AE ++ ++Q +S+ + +++ Q + +Q +D A ++ + +
Sbjct: 1766 AEELK-----KEQDTSAH---LERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQ---K 1814
Query: 1110 YEEDVEETEQNLD-EAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLE 1168
E V E E L+ E K + + + K + R++ + + EE + LL + + KL L+
Sbjct: 1815 LEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLK 1874
Query: 1169 ---YKARLEDSEE-------RLRRQQEEKD 1188
YK + E++EE + R+ Q E D
Sbjct: 1875 VKAYKRQAEEAEEQANTNLSKFRKVQHELD 1904
Score = 31.2 bits (69), Expect = 6.6
Identities = 29/140 (20%), Positives = 63/140 (45%), Gaps = 11/140 (7%)
Query: 1112 EDVEETEQNLDEAKHAEKYE-----QEITKLKE---RLRVSSRRLEEYERRLLVQ---EQ 1160
+D+E T +++ KHA + + +E+ L E +L + L+E ++ L E+
Sbjct: 955 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEE 1014
Query: 1161 QMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQ 1220
L + K +LE + L E++ + +E +LK + + + KQ
Sbjct: 1015 DKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQ 1074
Query: 1221 KIIDAQEKRIVSLDSANTRL 1240
++ + +K+ L++ N R+
Sbjct: 1075 QLDERLKKKDFELNALNARI 1094
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,575,498
Number of Sequences: 37866
Number of extensions: 2374079
Number of successful extensions: 14846
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 255
Number of HSP's successfully gapped in prelim test: 821
Number of HSP's that attempted gapping in prelim test: 9399
Number of HSP's gapped (non-prelim): 4116
length of query: 1280
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1166
effective length of database: 13,930,794
effective search space: 16243305804
effective search space used: 16243305804
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.