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Search of human proteins with 115430243
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|115430243 SCY1-like 1 isoform B [Homo sapiens]
(791 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115430243 SCY1-like 1 isoform B [Homo sapiens] 1617 0.0
gi|115430241 SCY1-like 1 isoform A [Homo sapiens] 1606 0.0
gi|170784850 SCY1-like 3 isoform 2 [Homo sapiens] 127 4e-29
gi|170784842 SCY1-like 3 isoform 1 [Homo sapiens] 127 4e-29
gi|47604944 SCY1-like 2 protein [Homo sapiens] 122 1e-27
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 56 1e-07
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 55 2e-07
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 55 3e-07
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 54 4e-07
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 54 4e-07
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 54 4e-07
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 54 4e-07
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 54 4e-07
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 53 1e-06
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 53 1e-06
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 53 1e-06
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 53 1e-06
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 51 4e-06
gi|5174547 mitogen-activated protein kinase kinase kinase 5 [Hom... 50 1e-05
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa... 49 1e-05
gi|166064027 cyclin-dependent kinase-like 3 isoform 1 [Homo sapi... 49 2e-05
gi|166064025 cyclin-dependent kinase-like 3 isoform 2 [Homo sapi... 49 2e-05
gi|93004081 polo-like kinase 2 [Homo sapiens] 48 3e-05
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 47 5e-05
gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens] 46 1e-04
gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Ho... 45 2e-04
gi|149158690 HLA-B associated transcript-2 [Homo sapiens] 45 2e-04
gi|121583542 mitogen-activated protein kinase kinase kinase 15 [... 45 2e-04
gi|41872673 NIMA-related kinase 1 [Homo sapiens] 45 3e-04
gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens] 44 4e-04
>gi|115430243 SCY1-like 1 isoform B [Homo sapiens]
Length = 791
Score = 1617 bits (4186), Expect = 0.0
Identities = 791/791 (100%), Positives = 791/791 (100%)
Query: 1 MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQV 60
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQV
Sbjct: 1 MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQV 60
Query: 61 AKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWG 120
AKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWG
Sbjct: 61 AKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWG 120
Query: 121 LHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE 180
LHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
Sbjct: 121 LHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE 180
Query: 181 LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHY 240
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHY
Sbjct: 181 LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHY 240
Query: 241 CELVGANPKVRPNPARFLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKS 300
CELVGANPKVRPNPARFLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKS
Sbjct: 241 CELVGANPKVRPNPARFLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKS 300
Query: 301 LDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS 360
LDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
Sbjct: 301 LDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS 360
Query: 361 TDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKSMLLLAPKLN 420
TDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKSMLLLAPKLN
Sbjct: 361 TDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKSMLLLAPKLN 420
Query: 421 EANLNVELMKHFARLQAKDEQGPIRCNTTVCLGKIGSYLSASTRHRVLTSAFSRATRDPF 480
EANLNVELMKHFARLQAKDEQGPIRCNTTVCLGKIGSYLSASTRHRVLTSAFSRATRDPF
Sbjct: 421 EANLNVELMKHFARLQAKDEQGPIRCNTTVCLGKIGSYLSASTRHRVLTSAFSRATRDPF 480
Query: 481 APSRVAGVLGFAATHNLYSMNDCAQKILPVLCGLTVDPEKSVRDQAFKAIRSFLSKLESV 540
APSRVAGVLGFAATHNLYSMNDCAQKILPVLCGLTVDPEKSVRDQAFKAIRSFLSKLESV
Sbjct: 481 APSRVAGVLGFAATHNLYSMNDCAQKILPVLCGLTVDPEKSVRDQAFKAIRSFLSKLESV 540
Query: 541 SEDPTQLEEVEKDVHAASSPGMGGAAASWAGWAVTGVSSLTSKLIRSHPTTAPTETNIPQ 600
SEDPTQLEEVEKDVHAASSPGMGGAAASWAGWAVTGVSSLTSKLIRSHPTTAPTETNIPQ
Sbjct: 541 SEDPTQLEEVEKDVHAASSPGMGGAAASWAGWAVTGVSSLTSKLIRSHPTTAPTETNIPQ 600
Query: 601 RPTPEGHWETQEEDKDTAEDSSTADRWDDEDWGSLEQEAESVLAQQDDWSTGGQVSRASQ 660
RPTPEGHWETQEEDKDTAEDSSTADRWDDEDWGSLEQEAESVLAQQDDWSTGGQVSRASQ
Sbjct: 601 RPTPEGHWETQEEDKDTAEDSSTADRWDDEDWGSLEQEAESVLAQQDDWSTGGQVSRASQ 660
Query: 661 VSNSDHKSSKSPESDWSSWEAEGSWEQGWQEPSSQEPPPDGTRLASEYNWGGPESSDKGD 720
VSNSDHKSSKSPESDWSSWEAEGSWEQGWQEPSSQEPPPDGTRLASEYNWGGPESSDKGD
Sbjct: 661 VSNSDHKSSKSPESDWSSWEAEGSWEQGWQEPSSQEPPPDGTRLASEYNWGGPESSDKGD 720
Query: 721 PFATLSARPSTQPRPDSWGEDNWEGLETDSRQVKAELARKKREERRREMEAKRAERKVAK 780
PFATLSARPSTQPRPDSWGEDNWEGLETDSRQVKAELARKKREERRREMEAKRAERKVAK
Sbjct: 721 PFATLSARPSTQPRPDSWGEDNWEGLETDSRQVKAELARKKREERRREMEAKRAERKVAK 780
Query: 781 GPMKLGARKLD 791
GPMKLGARKLD
Sbjct: 781 GPMKLGARKLD 791
>gi|115430241 SCY1-like 1 isoform A [Homo sapiens]
Length = 808
Score = 1606 bits (4158), Expect = 0.0
Identities = 791/808 (97%), Positives = 791/808 (97%), Gaps = 17/808 (2%)
Query: 1 MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQV 60
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQV
Sbjct: 1 MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQV 60
Query: 61 AKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWG 120
AKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWG
Sbjct: 61 AKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWG 120
Query: 121 LHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE 180
LHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
Sbjct: 121 LHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE 180
Query: 181 LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHY 240
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHY
Sbjct: 181 LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHY 240
Query: 241 CELVGANPKVRPNPARFLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKS 300
CELVGANPKVRPNPARFLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKS
Sbjct: 241 CELVGANPKVRPNPARFLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKS 300
Query: 301 LDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS 360
LDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
Sbjct: 301 LDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS 360
Query: 361 TDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKSMLLLAPKLN 420
TDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKSMLLLAPKLN
Sbjct: 361 TDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKSMLLLAPKLN 420
Query: 421 EANLNVELMKHFARLQAKDEQGPIRCNTTVCLGKIGSYLSASTRHRVLTSAFSRATRDPF 480
EANLNVELMKHFARLQAKDEQGPIRCNTTVCLGKIGSYLSASTRHRVLTSAFSRATRDPF
Sbjct: 421 EANLNVELMKHFARLQAKDEQGPIRCNTTVCLGKIGSYLSASTRHRVLTSAFSRATRDPF 480
Query: 481 APSRVAGVLGFAATHNLYSMNDCAQKILPVLCGLTVDPEKSVRDQAFKAIRSFLSKLESV 540
APSRVAGVLGFAATHNLYSMNDCAQKILPVLCGLTVDPEKSVRDQAFKAIRSFLSKLESV
Sbjct: 481 APSRVAGVLGFAATHNLYSMNDCAQKILPVLCGLTVDPEKSVRDQAFKAIRSFLSKLESV 540
Query: 541 SEDPTQLEEVEKDVHAASSPGMGGAAASWAGWAVTGVSSLTSKLIRSHPTTAPTETNIPQ 600
SEDPTQLEEVEKDVHAASSPGMGGAAASWAGWAVTGVSSLTSKLIRSHPTTAPTETNIPQ
Sbjct: 541 SEDPTQLEEVEKDVHAASSPGMGGAAASWAGWAVTGVSSLTSKLIRSHPTTAPTETNIPQ 600
Query: 601 RPTPE-----------------GHWETQEEDKDTAEDSSTADRWDDEDWGSLEQEAESVL 643
RPTPE GHWETQEEDKDTAEDSSTADRWDDEDWGSLEQEAESVL
Sbjct: 601 RPTPEGVPAPAPTPVPATPTTSGHWETQEEDKDTAEDSSTADRWDDEDWGSLEQEAESVL 660
Query: 644 AQQDDWSTGGQVSRASQVSNSDHKSSKSPESDWSSWEAEGSWEQGWQEPSSQEPPPDGTR 703
AQQDDWSTGGQVSRASQVSNSDHKSSKSPESDWSSWEAEGSWEQGWQEPSSQEPPPDGTR
Sbjct: 661 AQQDDWSTGGQVSRASQVSNSDHKSSKSPESDWSSWEAEGSWEQGWQEPSSQEPPPDGTR 720
Query: 704 LASEYNWGGPESSDKGDPFATLSARPSTQPRPDSWGEDNWEGLETDSRQVKAELARKKRE 763
LASEYNWGGPESSDKGDPFATLSARPSTQPRPDSWGEDNWEGLETDSRQVKAELARKKRE
Sbjct: 721 LASEYNWGGPESSDKGDPFATLSARPSTQPRPDSWGEDNWEGLETDSRQVKAELARKKRE 780
Query: 764 ERRREMEAKRAERKVAKGPMKLGARKLD 791
ERRREMEAKRAERKVAKGPMKLGARKLD
Sbjct: 781 ERRREMEAKRAERKVAKGPMKLGARKLD 808
>gi|170784850 SCY1-like 3 isoform 2 [Homo sapiens]
Length = 742
Score = 127 bits (319), Expect = 4e-29
Identities = 116/421 (27%), Positives = 185/421 (43%), Gaps = 57/421 (13%)
Query: 40 GSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTPL 99
G S+FVY E + +V KAA K KTLRHP +L ++ +H+VTE V PL
Sbjct: 34 GKFASVFVYK----RENEDKVNKAA-KHLKTLRHPCLLRFLSCTVEADGIHLVTERVQPL 88
Query: 100 GIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGG 159
+ L+ L E+ G++ I+ AL FL + L HNNVC+++VFV G WKLGG
Sbjct: 89 EVALET------LSSAEVCAGIYDILLALIFLHDRGHLTHNNVCLSSVFVSEDGHWKLGG 142
Query: 160 LD--------------YMYSAQGNGGGPPRKGIPELEQYDPPELADSSGRVVREKWSADM 205
++ + S + PP + PE L + G + D
Sbjct: 143 METVCKVSQATPEFLRSIQSIRDPASIPPEEMSPEF-----TTLPECHGH------ARDA 191
Query: 206 WRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPG 265
+ G L+ E L + +TL + L+ PK RP L +
Sbjct: 192 FSFGTLV-ESLLTILNEQVSADVLSSFQQTL---HSTLLNPIPKCRPALCTLLSH----- 242
Query: 266 GFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGN 325
F N F+E FL+ + +K EK +FF+ L + E+ +++P LL F
Sbjct: 243 DFFRNDFLEVVNFLKSLTLKSEEEKTEFFKFLLDRVSCLSEELIASRLVPLLLNQLVFAE 302
Query: 326 AGAVVLTPLFKVGK-----------FLSAEEYQQKIIPVVVKMFSSTDRAMRIRLLQQME 374
AV + +G LS +Q ++IPV++++F + +R+ LL +E
Sbjct: 303 PVAVKSFLPYLLGPKKDHAQGETPCLLSPALFQSRVIPVLLQLFEVHEEHVRMVLLSHIE 362
Query: 375 QFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKSMLLLAPKLN-EANLNVELMKHFA 433
++++ + + I P V+ G DT+ +I T+ S+ +L L E + E K F
Sbjct: 363 AYVEHFTQEQLKKVILPQVLLGLRDTSDSIVAITLHSLAVLVSLLGPEVVVGGERTKIFK 422
Query: 434 R 434
R
Sbjct: 423 R 423
>gi|170784842 SCY1-like 3 isoform 1 [Homo sapiens]
Length = 688
Score = 127 bits (319), Expect = 4e-29
Identities = 116/421 (27%), Positives = 185/421 (43%), Gaps = 57/421 (13%)
Query: 40 GSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTPL 99
G S+FVY E + +V KAA K KTLRHP +L ++ +H+VTE V PL
Sbjct: 34 GKFASVFVYK----RENEDKVNKAA-KHLKTLRHPCLLRFLSCTVEADGIHLVTERVQPL 88
Query: 100 GIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGG 159
+ L+ L E+ G++ I+ AL FL + L HNNVC+++VFV G WKLGG
Sbjct: 89 EVALET------LSSAEVCAGIYDILLALIFLHDRGHLTHNNVCLSSVFVSEDGHWKLGG 142
Query: 160 LD--------------YMYSAQGNGGGPPRKGIPELEQYDPPELADSSGRVVREKWSADM 205
++ + S + PP + PE L + G + D
Sbjct: 143 METVCKVSQATPEFLRSIQSIRDPASIPPEEMSPEF-----TTLPECHGH------ARDA 191
Query: 206 WRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPG 265
+ G L+ E L + +TL + L+ PK RP L +
Sbjct: 192 FSFGTLV-ESLLTILNEQVSADVLSSFQQTL---HSTLLNPIPKCRPALCTLLSH----- 242
Query: 266 GFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGN 325
F N F+E FL+ + +K EK +FF+ L + E+ +++P LL F
Sbjct: 243 DFFRNDFLEVVNFLKSLTLKSEEEKTEFFKFLLDRVSCLSEELIASRLVPLLLNQLVFAE 302
Query: 326 AGAVVLTPLFKVGK-----------FLSAEEYQQKIIPVVVKMFSSTDRAMRIRLLQQME 374
AV + +G LS +Q ++IPV++++F + +R+ LL +E
Sbjct: 303 PVAVKSFLPYLLGPKKDHAQGETPCLLSPALFQSRVIPVLLQLFEVHEEHVRMVLLSHIE 362
Query: 375 QFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKSMLLLAPKLN-EANLNVELMKHFA 433
++++ + + I P V+ G DT+ +I T+ S+ +L L E + E K F
Sbjct: 363 AYVEHFTQEQLKKVILPQVLLGLRDTSDSIVAITLHSLAVLVSLLGPEVVVGGERTKIFK 422
Query: 434 R 434
R
Sbjct: 423 R 423
>gi|47604944 SCY1-like 2 protein [Homo sapiens]
Length = 929
Score = 122 bits (307), Expect = 1e-27
Identities = 133/583 (22%), Positives = 246/583 (42%), Gaps = 65/583 (11%)
Query: 23 GGLPGPWALHRGRKKATGSPVSIFVYDVKPGAE----EQTQVA---KAAFKRFKTLRHPN 75
GG W + G KK+T V++FV+D K + E+ Q+ K ++ LRHP
Sbjct: 41 GGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGVQQLTRLRHPR 100
Query: 76 ILAYIDGLETEK-CLHVVTEAV-----TPLGIY------LKARVEAGGLKELEISWGLHQ 123
+L LE + CL TE V LG + + ++ L ++E +GL Q
Sbjct: 101 LLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSPISPDIKDYKLYDVETKYGLLQ 160
Query: 124 IVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPR-------K 176
+ + LSFL + ++H N+ + ++++G WK+ G D+ S+ P+
Sbjct: 161 VSEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSSTNPSEQEPKFPCKEWDP 220
Query: 177 GIPELEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLP--------------- 221
+P L +P LA V + ++DM+ LG +++ VFN P
Sbjct: 221 NLPSLCLPNPEYLAPEYILSVSCETASDMYSLGTVMYAVFNKGKPIFEVNKQDIYKSFSR 280
Query: 222 --------RAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSNRFV 273
+++L N IP+ + H L+ P VRP+ Q + P F +
Sbjct: 281 QLDQLSRLGSSSLTN---IPEEVREHVKLLLNVTPTVRPDAD---QMTKIP--FFDDVGA 332
Query: 274 ETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTP 333
T + + + ++ +K +FF+ L K L P+ ++LP L + F + VL
Sbjct: 333 VTLQYFDTLFQRDNLQKSQFFKGLPKVLPKLPKRVIVQRILPCLTSEFVNPDMVPFVLPN 392
Query: 334 LFKVGKFLSAEEYQQKIIPVVVKMFSSTDRAMRIRL-LQQMEQFIQYLDEPTVNTQIFPH 392
+ + + + EEY + I+P + +F + + + LQ+M+ + + + P
Sbjct: 393 VLLIAEECTKEEYVKLILPELGPVFKQQEPIQILLIFLQKMDLLLTKTPPDEIKNSVLPM 452
Query: 393 VVHGFLDTNPAIREQTVKSMLLLAPKLNEANLNVELMKHFARLQAKDEQGPIRCNTTVCL 452
V + I+E + + A ++ ++ L+ + +R N+ VCL
Sbjct: 453 VYRALEAPSIQIQELCLNIIPTFANLIDYPSMKNALIPRIKNACLQTSSLAVRVNSLVCL 512
Query: 453 GKIGSYLSA-STRHRVLTSAFSRATRDPFAPSRVAGVLGFAATHNLYSM--NDCAQKILP 509
GKI YL +L +++P + G+ TH + A K+LP
Sbjct: 513 GKILEYLDKWFVLDDILPFLQQIPSKEPAVLMGILGIYKCTFTHKKLGITKEQLAGKVLP 572
Query: 510 VLCGLTVDPEKSVR--DQAFKAIRSFLSKLESVSEDPTQLEEV 550
L L+++ ++ + I+ L++LE SE T+LE++
Sbjct: 573 HLIPLSIENNLNLNQFNSFISVIKEMLNRLE--SEHKTKLEQL 613
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 56.2 bits (134), Expect = 1e-07
Identities = 51/217 (23%), Positives = 100/217 (46%), Gaps = 18/217 (8%)
Query: 31 LHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH 90
+++GR+K + V++ +E++ + + + + LRHPNI+ +D ET+K +
Sbjct: 18 VYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVV 77
Query: 91 VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVD 150
VVT+ G + + G L E ++ Q+V AL +L + ++H ++ + +
Sbjct: 78 VVTDYAE--GELFQILEDDGKLPEDQVQAIAAQLVSALYYL-HSHRILHRDMKPQNILLA 134
Query: 151 RAGEWKLGGLDYMYSAQGNGGGPPRKGIPELEQYDPPELADSSGRVVREKWSADMWRLGC 210
+ G KL D+ ++ + I Y PEL + +AD+W +GC
Sbjct: 135 KGGGIKL--CDFGFARAMSTNTMVLTSIKGTPLYMSPELVEER----PYDHTADLWSVGC 188
Query: 211 LIWEVFNGPLPRAAA---------LRNPGKIPKTLVP 238
+++E+ G P A L++P + P T+ P
Sbjct: 189 ILYELAVGTPPFYATSIFQLVSLILKDPVRWPSTISP 225
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 55.5 bits (132), Expect = 2e-07
Identities = 51/193 (26%), Positives = 84/193 (43%), Gaps = 28/193 (14%)
Query: 39 TGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTP 98
TG V+I + D Q + K L HPNI+ + +ETEK L++V E +
Sbjct: 81 TGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYAS- 139
Query: 99 LGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLG 158
G V G +KE E QIV A+ + + +++H ++ + +D K+
Sbjct: 140 AGEVFDYLVSHGRMKEKEARAKFRQIVSAVHY-CHQKNIVHRDLKAENLLLDAEANIKIA 198
Query: 159 GLDYMYSAQGNGG-------GPPRKGIPEL---EQYDPPELADSSGRVVREKWSADMWRL 208
D+ +S + G G P PEL ++YD PE+ D+W L
Sbjct: 199 --DFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEV--------------DIWSL 242
Query: 209 GCLIWEVFNGPLP 221
G +++ + +G LP
Sbjct: 243 GVILYTLVSGSLP 255
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 54.7 bits (130), Expect = 3e-07
Identities = 56/218 (25%), Positives = 91/218 (41%), Gaps = 37/218 (16%)
Query: 35 RKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTE 94
R TG V++ + D Q + K L HPNI+ + +ETEK L++V E
Sbjct: 78 RHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVME 137
Query: 95 AVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGE 154
+ G V G +KE E QIV A+ + + ++H ++ + +D G+
Sbjct: 138 YASG-GEVFDYLVAHGRMKEKEARAKFRQIVSAVQY-CHQKYIVHRDLKAENLLLD--GD 193
Query: 155 WKLGGLDYMYSAQGNGG-------GPPRKGIPEL---EQYDPPELADSSGRVVREKWSAD 204
+ D+ +S + G G P PEL ++YD PE+ D
Sbjct: 194 MNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEV--------------D 239
Query: 205 MWRLGCLIWEVFNGPLP---------RAAALRNPGKIP 233
+W LG +++ + +G LP R LR +IP
Sbjct: 240 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP 277
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 54.3 bits (129), Expect = 4e-07
Identities = 55/214 (25%), Positives = 89/214 (41%), Gaps = 37/214 (17%)
Query: 39 TGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTP 98
TG V++ + D Q + K L HPNI+ + +ETEK L++V E +
Sbjct: 75 TGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASG 134
Query: 99 LGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLG 158
G V G +KE E QIV A+ + + ++H ++ + +D K+
Sbjct: 135 -GEVFDYLVAHGRMKEKEARAKFRQIVSAVQY-CHQKFIVHRDLKAENLLLDADMNIKIA 192
Query: 159 GLDYMYSAQGNGG-------GPPRKGIPEL---EQYDPPELADSSGRVVREKWSADMWRL 208
D+ +S + G G P PEL ++YD PE+ D+W L
Sbjct: 193 --DFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV--------------DVWSL 236
Query: 209 GCLIWEVFNGPLP---------RAAALRNPGKIP 233
G +++ + +G LP R LR +IP
Sbjct: 237 GVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP 270
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 54.3 bits (129), Expect = 4e-07
Identities = 55/214 (25%), Positives = 89/214 (41%), Gaps = 37/214 (17%)
Query: 39 TGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTP 98
TG V++ + D Q + K L HPNI+ + +ETEK L++V E +
Sbjct: 75 TGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASG 134
Query: 99 LGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLG 158
G V G +KE E QIV A+ + + ++H ++ + +D K+
Sbjct: 135 -GEVFDYLVAHGRMKEKEARAKFRQIVSAVQY-CHQKFIVHRDLKAENLLLDADMNIKIA 192
Query: 159 GLDYMYSAQGNGG-------GPPRKGIPEL---EQYDPPELADSSGRVVREKWSADMWRL 208
D+ +S + G G P PEL ++YD PE+ D+W L
Sbjct: 193 --DFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV--------------DVWSL 236
Query: 209 GCLIWEVFNGPLP---------RAAALRNPGKIP 233
G +++ + +G LP R LR +IP
Sbjct: 237 GVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP 270
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 54.3 bits (129), Expect = 4e-07
Identities = 55/214 (25%), Positives = 89/214 (41%), Gaps = 37/214 (17%)
Query: 39 TGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTP 98
TG V++ + D Q + K L HPNI+ + +ETEK L++V E +
Sbjct: 75 TGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASG 134
Query: 99 LGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLG 158
G V G +KE E QIV A+ + + ++H ++ + +D K+
Sbjct: 135 -GEVFDYLVAHGRMKEKEARAKFRQIVSAVQY-CHQKFIVHRDLKAENLLLDADMNIKIA 192
Query: 159 GLDYMYSAQGNGG-------GPPRKGIPEL---EQYDPPELADSSGRVVREKWSADMWRL 208
D+ +S + G G P PEL ++YD PE+ D+W L
Sbjct: 193 --DFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV--------------DVWSL 236
Query: 209 GCLIWEVFNGPLP---------RAAALRNPGKIP 233
G +++ + +G LP R LR +IP
Sbjct: 237 GVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP 270
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 54.3 bits (129), Expect = 4e-07
Identities = 55/214 (25%), Positives = 89/214 (41%), Gaps = 37/214 (17%)
Query: 39 TGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTP 98
TG V++ + D Q + K L HPNI+ + +ETEK L++V E +
Sbjct: 75 TGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASG 134
Query: 99 LGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLG 158
G V G +KE E QIV A+ + + ++H ++ + +D K+
Sbjct: 135 -GEVFDYLVAHGRMKEKEARAKFRQIVSAVQY-CHQKFIVHRDLKAENLLLDADMNIKIA 192
Query: 159 GLDYMYSAQGNGG-------GPPRKGIPEL---EQYDPPELADSSGRVVREKWSADMWRL 208
D+ +S + G G P PEL ++YD PE+ D+W L
Sbjct: 193 --DFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV--------------DVWSL 236
Query: 209 GCLIWEVFNGPLP---------RAAALRNPGKIP 233
G +++ + +G LP R LR +IP
Sbjct: 237 GVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP 270
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 54.3 bits (129), Expect = 4e-07
Identities = 55/214 (25%), Positives = 89/214 (41%), Gaps = 37/214 (17%)
Query: 39 TGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTP 98
TG V++ + D Q + K L HPNI+ + +ETEK L++V E +
Sbjct: 42 TGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASG 101
Query: 99 LGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLG 158
G V G +KE E QIV A+ + + ++H ++ + +D K+
Sbjct: 102 -GEVFDYLVAHGRMKEKEARAKFRQIVSAVQY-CHQKFIVHRDLKAENLLLDADMNIKIA 159
Query: 159 GLDYMYSAQGNGG-------GPPRKGIPEL---EQYDPPELADSSGRVVREKWSADMWRL 208
D+ +S + G G P PEL ++YD PE+ D+W L
Sbjct: 160 --DFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV--------------DVWSL 203
Query: 209 GCLIWEVFNGPLP---------RAAALRNPGKIP 233
G +++ + +G LP R LR +IP
Sbjct: 204 GVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP 237
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 53.1 bits (126), Expect = 1e-06
Identities = 55/214 (25%), Positives = 89/214 (41%), Gaps = 37/214 (17%)
Query: 39 TGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTP 98
TG V+I + D Q + K L HPNI+ + +ETEK L+++ E +
Sbjct: 78 TGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASG 137
Query: 99 LGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLG 158
G V G +KE E QIV A+ + + ++H ++ + +D K+
Sbjct: 138 -GEVFDYLVAHGRMKEKEARSKFRQIVSAVQY-CHQKRIVHRDLKAENLLLDADMNIKIA 195
Query: 159 GLDYMYSAQGNGG-------GPPRKGIPEL---EQYDPPELADSSGRVVREKWSADMWRL 208
D+ +S + G G P PEL ++YD PE+ D+W L
Sbjct: 196 --DFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEV--------------DVWSL 239
Query: 209 GCLIWEVFNGPLP---------RAAALRNPGKIP 233
G +++ + +G LP R LR +IP
Sbjct: 240 GVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP 273
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 53.1 bits (126), Expect = 1e-06
Identities = 55/214 (25%), Positives = 89/214 (41%), Gaps = 37/214 (17%)
Query: 39 TGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTP 98
TG V+I + D Q + K L HPNI+ + +ETEK L+++ E +
Sbjct: 78 TGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASG 137
Query: 99 LGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLG 158
G V G +KE E QIV A+ + + ++H ++ + +D K+
Sbjct: 138 -GEVFDYLVAHGRMKEKEARSKFRQIVSAVQY-CHQKRIVHRDLKAENLLLDADMNIKIA 195
Query: 159 GLDYMYSAQGNGG-------GPPRKGIPEL---EQYDPPELADSSGRVVREKWSADMWRL 208
D+ +S + G G P PEL ++YD PE+ D+W L
Sbjct: 196 --DFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEV--------------DVWSL 239
Query: 209 GCLIWEVFNGPLP---------RAAALRNPGKIP 233
G +++ + +G LP R LR +IP
Sbjct: 240 GVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP 273
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 53.1 bits (126), Expect = 1e-06
Identities = 55/214 (25%), Positives = 89/214 (41%), Gaps = 37/214 (17%)
Query: 39 TGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTP 98
TG V+I + D Q + K L HPNI+ + +ETEK L+++ E +
Sbjct: 78 TGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASG 137
Query: 99 LGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLG 158
G V G +KE E QIV A+ + + ++H ++ + +D K+
Sbjct: 138 -GEVFDYLVAHGRMKEKEARSKFRQIVSAVQY-CHQKRIVHRDLKAENLLLDADMNIKIA 195
Query: 159 GLDYMYSAQGNGG-------GPPRKGIPEL---EQYDPPELADSSGRVVREKWSADMWRL 208
D+ +S + G G P PEL ++YD PE+ D+W L
Sbjct: 196 --DFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEV--------------DVWSL 239
Query: 209 GCLIWEVFNGPLP---------RAAALRNPGKIP 233
G +++ + +G LP R LR +IP
Sbjct: 240 GVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP 273
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 53.1 bits (126), Expect = 1e-06
Identities = 55/214 (25%), Positives = 89/214 (41%), Gaps = 37/214 (17%)
Query: 39 TGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTP 98
TG V+I + D Q + K L HPNI+ + +ETEK L+++ E +
Sbjct: 78 TGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASG 137
Query: 99 LGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLG 158
G V G +KE E QIV A+ + + ++H ++ + +D K+
Sbjct: 138 -GEVFDYLVAHGRMKEKEARSKFRQIVSAVQY-CHQKRIVHRDLKAENLLLDADMNIKIA 195
Query: 159 GLDYMYSAQGNGG-------GPPRKGIPEL---EQYDPPELADSSGRVVREKWSADMWRL 208
D+ +S + G G P PEL ++YD PE+ D+W L
Sbjct: 196 --DFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEV--------------DVWSL 239
Query: 209 GCLIWEVFNGPLP---------RAAALRNPGKIP 233
G +++ + +G LP R LR +IP
Sbjct: 240 GVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP 273
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 51.2 bits (121), Expect = 4e-06
Identities = 44/160 (27%), Positives = 73/160 (45%), Gaps = 10/160 (6%)
Query: 71 LRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELE-ISWGLHQIVKALS 129
L+H NI+AY + L + E +Y K + L E E + W L QIV A+S
Sbjct: 106 LQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVS 165
Query: 130 FLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPELEQYDPPEL 189
++ ++H ++ +F+ +A KLG DY + + N + + Y PEL
Sbjct: 166 -CIHKAGILHRDIKTLNIFLTKANLIKLG--DYGLAKKLNSEYSMAETLVGTPYYMSPEL 222
Query: 190 ADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNP 229
V+ + +D+W +GC+I+E+ L R NP
Sbjct: 223 CQG----VKYNFKSDIWAVGCVIFELLT--LKRTFDATNP 256
>gi|5174547 mitogen-activated protein kinase kinase kinase 5 [Homo
sapiens]
Length = 1374
Score = 49.7 bits (117), Expect = 1e-05
Identities = 66/256 (25%), Positives = 111/256 (43%), Gaps = 26/256 (10%)
Query: 69 KTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWGLH--QIVK 126
K L+H NI+ Y+ + + E V + R + G LK+ E + G + QI++
Sbjct: 730 KHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILE 789
Query: 127 ALSFLVNDCSLIHNNVCMAAVFVDR-AGEWKLGGLDYMYSAQGNGGGPPRKGIPELEQYD 185
L +L +D ++H ++ V ++ +G K+ D+ S + G P + QY
Sbjct: 790 GLKYL-HDNQIVHRDIKGDNVLINTYSGVLKIS--DFGTSKRLAGINPCTETFTGTLQYM 846
Query: 186 PPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLP------RAAALRNPGKIPKTLVPH 239
PE+ D R + +AD+W LGC I E+ G P AA+ G + P
Sbjct: 847 APEIIDKGPRGYGK--AADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMF--KVHPE 902
Query: 240 YCELVGANPKVRPNPARFLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSK 299
E + A K F+ C P R +L ++E +K ++K+K +LS
Sbjct: 903 IPESMSAEAKA------FILKCFEPD--PDKRACANDLLVDEF-LKVSSKKKKTQPKLS- 952
Query: 300 SLDAFPEDFCRHKVLP 315
+L A ++ R LP
Sbjct: 953 ALSAGSNEYLRSISLP 968
>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
sapiens]
Length = 714
Score = 49.3 bits (116), Expect = 1e-05
Identities = 52/196 (26%), Positives = 85/196 (43%), Gaps = 14/196 (7%)
Query: 31 LHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKT---LRHPNILAYIDGLETEK 87
+ G TG V+I V D K A++ T V K + + +RHPNI +D LETE
Sbjct: 76 VREGLHVLTGEKVAIKVID-KKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDILETEN 134
Query: 88 CLHVVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAV 147
++V E + P G + E L+E E + Q++ A+ L + ++H ++ + +
Sbjct: 135 SYYLVME-LCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHL-HRAGVVHRDLKIENL 192
Query: 148 FVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPELEQYDPPELADSSGRVVREKW--SADM 205
+D KL A G P Y PEL + R+K+ D+
Sbjct: 193 LLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPEL------LARKKYGPKIDV 246
Query: 206 WRLGCLIWEVFNGPLP 221
W +G ++ + G LP
Sbjct: 247 WSIGVNMYAMLTGTLP 262
>gi|166064027 cyclin-dependent kinase-like 3 isoform 1 [Homo
sapiens]
Length = 592
Score = 48.9 bits (115), Expect = 2e-05
Identities = 55/222 (24%), Positives = 99/222 (44%), Gaps = 19/222 (8%)
Query: 35 RKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTE 94
+ K TG V+I ++ +P + ++A K K H N++ I+ +K +H+V E
Sbjct: 22 KHKNTGQIVAIKIFYERP-EQSVNKIAMREIKFLKQFHHENLVNLIEVFRQKKKIHLVFE 80
Query: 95 AVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGE 154
+ + + + GL+ + L QI++A+ +L ++ ++IH ++ + V ++G
Sbjct: 81 FIDHT-VLDELQHYCHGLESKRLRKYLFQILRAIDYLHSN-NIIHRDIKPENILVSQSGI 138
Query: 155 WKLGGLDYMYSAQGNGGGPPRKGIPELEQYDPPELA---DSSGRVVREKWSADMWRLGCL 211
KL D+ ++ G Y PEL S G+ V D+W LGC+
Sbjct: 139 TKL--CDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKPV------DIWALGCM 190
Query: 212 IWEVFNGP--LPRAAALRNPGKI---PKTLVPHYCELVGANP 248
I E+ G LP ++ L KI L PH + +P
Sbjct: 191 IIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSP 232
>gi|166064025 cyclin-dependent kinase-like 3 isoform 2 [Homo
sapiens]
Length = 455
Score = 48.9 bits (115), Expect = 2e-05
Identities = 55/222 (24%), Positives = 99/222 (44%), Gaps = 19/222 (8%)
Query: 35 RKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTE 94
+ K TG V+I ++ +P + ++A K K H N++ I+ +K +H+V E
Sbjct: 22 KHKNTGQIVAIKIFYERP-EQSVNKIAMREIKFLKQFHHENLVNLIEVFRQKKKIHLVFE 80
Query: 95 AVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGE 154
+ + + + GL+ + L QI++A+ +L ++ ++IH ++ + V ++G
Sbjct: 81 FIDHT-VLDELQHYCHGLESKRLRKYLFQILRAIDYLHSN-NIIHRDIKPENILVSQSGI 138
Query: 155 WKLGGLDYMYSAQGNGGGPPRKGIPELEQYDPPELA---DSSGRVVREKWSADMWRLGCL 211
KL D+ ++ G Y PEL S G+ V D+W LGC+
Sbjct: 139 TKL--CDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKPV------DIWALGCM 190
Query: 212 IWEVFNGP--LPRAAALRNPGKI---PKTLVPHYCELVGANP 248
I E+ G LP ++ L KI L PH + +P
Sbjct: 191 IIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSP 232
>gi|93004081 polo-like kinase 2 [Homo sapiens]
Length = 685
Score = 48.1 bits (113), Expect = 3e-05
Identities = 55/259 (21%), Positives = 113/259 (43%), Gaps = 28/259 (10%)
Query: 69 KTLRHPNILAYIDGLETEKCLHVVTEAVT--PLGIYLKARVEAGGLKELEISWGLHQIVK 126
+ L H +++ + E ++ ++++ E + + LKAR L E E+ + L QIV
Sbjct: 135 RILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKV---LTEPEVRYYLRQIVS 191
Query: 127 ALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPELEQYDP 186
L +L ++ ++H ++ + F++ A E K+G D+ +A+ R+ I Y
Sbjct: 192 GLKYL-HEQEILHRDLKLGNFFINEAMELKVG--DFGLAARLEPLEHRRRTICGTPNYLS 248
Query: 187 PELADSSGRVVREKWSADMWRLGCLIWEVFNGPLP-------------RAAALRNPGKIP 233
PE+ + G +D+W LGC+++ + G P R A P +
Sbjct: 249 PEVLNKQGHGCE----SDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLL 304
Query: 234 KTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSNRFVETNLF-LEEIQIKEPAEKQK 292
++ NP+ RP+ +++ GF +R + + + + PA +
Sbjct: 305 APAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPA--KN 362
Query: 293 FFQELSKSLDAFPEDFCRH 311
FF++ + +L +D R+
Sbjct: 363 FFKKAAAALFGGKKDKARY 381
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 47.4 bits (111), Expect = 5e-05
Identities = 57/225 (25%), Positives = 89/225 (39%), Gaps = 37/225 (16%)
Query: 18 PEPPEGG-LPGPWALHRGRKKA------------TGSPVSIFVYDVKPGAEEQTQVAKAA 64
P PP+ GP+ L + K TG V+I + + + +E +
Sbjct: 22 PHPPQHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVERE 81
Query: 65 FKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWGLHQI 124
K + HP++L D E +K L++V E V+ G V+ G L E QI
Sbjct: 82 IAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSG-GELFDYLVKKGRLTPKEARKFFRQI 140
Query: 125 VKALSFLVNDCSLIHNNVCMAAVFVD-----RAGEWKLGGLDYMYSAQGNGGGPPRKGIP 179
V AL F + S+ H ++ + +D R ++ + L S G P P
Sbjct: 141 VSALDF-CHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACP 199
Query: 180 EL---EQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLP 221
E+ E+YD GR ADMW G +++ + G LP
Sbjct: 200 EVIKGEKYD--------GR------RADMWSCGVILFALLVGALP 230
>gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens]
Length = 493
Score = 46.2 bits (108), Expect = 1e-04
Identities = 55/219 (25%), Positives = 93/219 (42%), Gaps = 12/219 (5%)
Query: 35 RKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTE 94
R K TG V+I + + ++A K K LRH N++ ++ + +K ++V E
Sbjct: 22 RNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFE 81
Query: 95 AVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGE 154
V I + GL + L QI+ + F + ++IH ++ + V ++G
Sbjct: 82 FVDHT-ILDDLELFPNGLDYQVVQKYLFQIINGIGFC-HSHNIIHRDIKPENILVSQSGV 139
Query: 155 WKLGGLDYMYSAQGNGGGPPRKGIPELEQYDPPELADSSGRVVREKWSADMWRLGCLIWE 214
KL D+ ++ G Y PEL V+ + D+W +GCL+ E
Sbjct: 140 VKL--CDFGFARTLAAPGEVYTDYVATRWYRAPELLVGD---VKYGKAVDVWAIGCLVTE 194
Query: 215 VFNG-PL-PRAAALRNPGKIPK---TLVPHYCELVGANP 248
+F G PL P + + I L+P + EL NP
Sbjct: 195 MFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNP 233
>gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Homo
sapiens]
Length = 1288
Score = 45.4 bits (106), Expect = 2e-04
Identities = 44/156 (28%), Positives = 72/156 (46%), Gaps = 8/156 (5%)
Query: 69 KTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELE--ISWGLHQIVK 126
+ LRH NI+ Y+ L + E V + R G LK+ E IS+ QI++
Sbjct: 698 RRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQ 757
Query: 127 ALSFLVNDCSLIHNNVCMAAVFVDR-AGEWKLGGLDYMYSAQGNGGGPPRKGIPELEQYD 185
L +L +D ++H ++ V ++ +G K+ D+ S + G P + QY
Sbjct: 758 GLGYL-HDNHIVHRDIKGDNVLINTFSGLLKIS--DFGTSKRLAGITPCTETFTGTLQYM 814
Query: 186 PPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLP 221
PE+ D R + +AD+W LGC + E+ G P
Sbjct: 815 APEIIDQGPRGYGK--AADIWSLGCTVIEMATGRPP 848
>gi|149158690 HLA-B associated transcript-2 [Homo sapiens]
Length = 2157
Score = 45.4 bits (106), Expect = 2e-04
Identities = 43/185 (23%), Positives = 69/185 (37%), Gaps = 16/185 (8%)
Query: 608 WETQEEDKDTAEDSSTADRWDDEDWGSLEQEAESVLAQQDDWSTGGQV---SRASQVSNS 664
W E+ D E +D D D + E +D S G+ + NS
Sbjct: 326 WAGAHEEVDYTEKLKFSDEEDGRD-----SDEEGAEGHRDSQSASGEERPPEADGKKGNS 380
Query: 665 DHKSSKSPESDWSSWEAEGSWEQGWQEPSSQEPPPDGTRLASEYNWGGP-ESSDKGDPFA 723
+ +P++ W+ E G P PPP NWG P + D+G P
Sbjct: 381 PNSEPPTPKTAWAETSRPPETEPGPPAPKPPLPPP---HRGPAGNWGPPGDYPDRGGPPC 437
Query: 724 TLSARPSTQPRPDSWGEDNWEGLETDSRQVKAELARKKREERRREMEAKRA-ERKVAKGP 782
P+ + ++W + + S V+ R++ EERR + E + A K+ +
Sbjct: 438 K---PPAPEDEDEAWRQRRKQSSSEISLAVERARRRREEEERRMQEERRAACAEKLKRLD 494
Query: 783 MKLGA 787
K GA
Sbjct: 495 EKFGA 499
>gi|121583542 mitogen-activated protein kinase kinase kinase 15
[Homo sapiens]
Length = 788
Score = 45.4 bits (106), Expect = 2e-04
Identities = 41/154 (26%), Positives = 69/154 (44%), Gaps = 6/154 (3%)
Query: 69 KTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKAL 128
K L+H NI+ Y+ + + + E V + R + G +KE I + QI++ L
Sbjct: 177 KYLKHRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGL 236
Query: 129 SFLVNDCSLIHNNVCMAAVFVDR-AGEWKLGGLDYMYSAQGNGGGPPRKGIPELEQYDPP 187
+L ++ ++H ++ V V+ +G K+ D+ S + G P + QY P
Sbjct: 237 KYL-HENQIVHRDIKGDNVLVNTYSGVVKIS--DFGTSKRLAGVNPCTETFTGTLQYMAP 293
Query: 188 ELADSSGRVVREKWSADMWRLGCLIWEVFNGPLP 221
E+ D R AD+W LGC I E+ P
Sbjct: 294 EIIDQGPRGYGA--PADIWSLGCTIIEMATSKPP 325
>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
Length = 1258
Score = 44.7 bits (104), Expect = 3e-04
Identities = 59/254 (23%), Positives = 106/254 (41%), Gaps = 37/254 (14%)
Query: 51 KPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAG 110
K E + +VA A ++HPNI+ Y + E L++V + ++ + + G
Sbjct: 43 KEREESRREVAVLA-----NMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKG 97
Query: 111 GL-KELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGN 169
L +E +I QI AL V+D ++H ++ +F+ + G +LG D+ + N
Sbjct: 98 VLFQEDQILDWFVQICLALKH-VHDRKILHRDIKSQNIFLTKDGTVQLG--DFGIARVLN 154
Query: 170 GGGPPRKGIPELEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFN-------GPLPR 222
+ Y PE+ ++ + K +D+W LGC+++E+ G +
Sbjct: 155 STVELARTCIGTPYYLSPEICEN--KPYNNK--SDIWALGCVLYELCTLKHAFEAGSMKN 210
Query: 223 AAALRNPGKIPKTLVPHY--------CELVGANPKVRPNPARFLQNCRAPGGFMSNR--- 271
G P + HY +L NP+ RP+ L+ GF++ R
Sbjct: 211 LVLKIISGSFPPVSL-HYSYDLRSLVSQLFKRNPRDRPSVNSILEK-----GFIAKRIEK 264
Query: 272 FVETNLFLEEIQIK 285
F+ L EE +K
Sbjct: 265 FLSPQLIAEEFCLK 278
>gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
Length = 544
Score = 44.3 bits (103), Expect = 4e-04
Identities = 47/174 (27%), Positives = 81/174 (46%), Gaps = 15/174 (8%)
Query: 73 HPNILAYIDGL--ETEKCLHVVTEAVTPLGIYLKARVEAGGL-KELEISWGLHQIVKALS 129
HPNI++ +D + E ++ +++V E + L A + GGL +++ + +Q+++A
Sbjct: 70 HPNIISLLDVIRAENDRDIYLVFEF---MDTDLNAVIRKGGLLQDVHVRSIFYQLLRATR 126
Query: 130 FLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPEL---EQYDP 186
FL + ++H + + V +D KL S GP + + E Y
Sbjct: 127 FL-HSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRA 185
Query: 187 PELADSSGRVVREKWSADMWRLGCLIWEVFNG-PL-PRAAALRNPGKIPKTLVP 238
PE+ SS R DMW LGC++ E+ G PL P + L I +T+ P
Sbjct: 186 PEVLLSSHRYTL---GVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPP 236
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,459,054
Number of Sequences: 37866
Number of extensions: 1751288
Number of successful extensions: 9265
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 47
Number of HSP's successfully gapped in prelim test: 298
Number of HSP's that attempted gapping in prelim test: 8762
Number of HSP's gapped (non-prelim): 720
length of query: 791
length of database: 18,247,518
effective HSP length: 110
effective length of query: 681
effective length of database: 14,082,258
effective search space: 9590017698
effective search space used: 9590017698
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.