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Search of human proteins with 224589129
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224589129 karyopherin 7 [Homo sapiens]
(516 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224589129 karyopherin 7 [Homo sapiens] 1012 0.0
gi|4504897 karyopherin alpha 2 [Homo sapiens] 544 e-155
gi|4504901 karyopherin alpha 4 [Homo sapiens] 428 e-120
gi|34485722 karyopherin alpha 3 [Homo sapiens] 427 e-120
gi|222144293 karyopherin alpha 1 [Homo sapiens] 379 e-105
gi|6912478 karyopherin alpha 6 [Homo sapiens] 378 e-105
gi|39812229 karyopherin alpha 5 [Homo sapiens] 372 e-103
gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens] 79 1e-14
gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens] 79 1e-14
gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens] 65 1e-10
gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens] 62 2e-09
gi|148227672 catenin (cadherin-associated protein), beta 1, 88kD... 54 3e-07
gi|148233338 catenin (cadherin-associated protein), beta 1, 88kD... 54 3e-07
gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa ... 54 3e-07
gi|32526896 armadillo repeat containing 8 isoform 2 [Homo sapiens] 54 3e-07
gi|189409124 armadillo repeat containing 3 [Homo sapiens] 53 8e-07
gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5 [... 52 1e-06
gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4 [... 52 1e-06
gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3 [... 48 2e-05
gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2 [... 48 2e-05
gi|155030192 RAP1, GTP-GDP dissociation stimulator 1 isoform 1 [... 48 2e-05
gi|53829376 plakophilin 4 isoform b [Homo sapiens] 44 4e-04
gi|53829374 plakophilin 4 isoform a [Homo sapiens] 44 4e-04
gi|155030202 RAP1, GTP-GDP dissociation stimulator 1 isoform 6 [... 44 5e-04
gi|90669931 tetratricopeptide repeat domain 12 [Homo sapiens] 42 0.001
gi|31657114 armadillo repeat containing 4 [Homo sapiens] 42 0.001
gi|4504811 junction plakoglobin [Homo sapiens] 40 0.004
gi|12056468 junction plakoglobin [Homo sapiens] 40 0.004
gi|47458043 armadillo repeat containing 8 isoform 3 [Homo sapiens] 39 0.009
gi|47458045 armadillo repeat containing 8 isoform 1 [Homo sapiens] 39 0.009
>gi|224589129 karyopherin 7 [Homo sapiens]
Length = 516
Score = 1012 bits (2617), Expect = 0.0
Identities = 516/516 (100%), Positives = 516/516 (100%)
Query: 1 MPTLDAPEERRRKFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNITSFCPDTPSE 60
MPTLDAPEERRRKFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNITSFCPDTPSE
Sbjct: 1 MPTLDAPEERRRKFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNITSFCPDTPSE 60
Query: 61 KTAKGVAVSLTLGEIIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVE 120
KTAKGVAVSLTLGEIIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVE
Sbjct: 61 KTAKGVAVSLTLGEIIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVE 120
Query: 121 FLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWAL 180
FLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWAL
Sbjct: 121 FLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWAL 180
Query: 181 GNIAGDGPEFRDNVITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVK 240
GNIAGDGPEFRDNVITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVK
Sbjct: 181 GNIAGDGPEFRDNVITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVK 240
Query: 241 QILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVL 300
QILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVL
Sbjct: 241 QILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVL 300
Query: 301 TPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHI 360
TPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHI
Sbjct: 301 TPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHI 360
Query: 361 QQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLT 420
QQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLT
Sbjct: 361 QQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLT 420
Query: 421 APDVKIVLIILDVISCILQAAEKRSEKENLCLLIEELGGIDRIEALQLHENRQIGQSALN 480
APDVKIVLIILDVISCILQAAEKRSEKENLCLLIEELGGIDRIEALQLHENRQIGQSALN
Sbjct: 421 APDVKIVLIILDVISCILQAAEKRSEKENLCLLIEELGGIDRIEALQLHENRQIGQSALN 480
Query: 481 IIEKHFGEEEDESQTLLSQVIDQDYEFIDYECLAKK 516
IIEKHFGEEEDESQTLLSQVIDQDYEFIDYECLAKK
Sbjct: 481 IIEKHFGEEEDESQTLLSQVIDQDYEFIDYECLAKK 516
>gi|4504897 karyopherin alpha 2 [Homo sapiens]
Length = 529
Score = 544 bits (1401), Expect = e-155
Identities = 280/510 (54%), Positives = 371/510 (72%), Gaps = 7/510 (1%)
Query: 5 DAPEERRRKFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNITSFCPDTPS---EK 61
+ P R +FK +GKD + R++R+ V++ELRKAKKD+Q LKRRN++SF D S E
Sbjct: 8 NTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQEN 67
Query: 62 TAKGVAVSLTLGEIIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVEF 121
V+ ++ +I+KG+NSS+ QATQ ARK+LS+EK PP+ +I AGLIP+ V F
Sbjct: 68 RNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSF 127
Query: 122 LKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALG 181
L + +QFE+AWALTNIASGTSEQT+AVV+GGAI I LL+S + + EQAVWALG
Sbjct: 128 LGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALG 187
Query: 182 NIAGDGPEFRDNVITSNAIPHLLALIS----PTLPITFLRNITWTLSNLCRNKNPYPCDT 237
NIAGDG FRD VI A+ LLAL++ +L +LRN+TWTLSNLCRNKNP P
Sbjct: 188 NIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPID 247
Query: 238 AVKQILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSEL 297
AV+QILP L+ LL H D EVL+D CWA+SYLTDG N+RIG VV TGV+P+LV L+ +SEL
Sbjct: 248 AVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASEL 307
Query: 298 NVLTPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPC 357
++TP+LR +GNIVTGTDEQTQ+ IDAG L V P LL + K +IQKEA W +SN+ AG
Sbjct: 308 PIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQ 367
Query: 358 HHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVN 417
IQQ++ + ++P LV++L +FK QKEAVW V N+ +G T++Q++ LVH G++EPL+N
Sbjct: 368 DQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMN 427
Query: 418 LLTAPDVKIVLIILDVISCILQAAEKRSEKENLCLLIEELGGIDRIEALQLHENRQIGQS 477
LLTA D KI+L+ILD IS I QAAEK E E L ++IEE GG+D+IEALQ HEN + ++
Sbjct: 428 LLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKA 487
Query: 478 ALNIIEKHFGEEEDESQTLLSQVIDQDYEF 507
+L++IEK+F EE+E Q ++ + + Y F
Sbjct: 488 SLSLIEKYFSVEEEEDQNVVPETTSEGYTF 517
>gi|4504901 karyopherin alpha 4 [Homo sapiens]
Length = 521
Score = 428 bits (1100), Expect = e-120
Identities = 224/496 (45%), Positives = 322/496 (64%), Gaps = 7/496 (1%)
Query: 9 ERRRKFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNIT--SFCPDTPSEKTAKGV 66
+R + FK +G+D+ R+QR V +ELRK K+DE LKRRN+ C D+ + +
Sbjct: 10 QRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICEDSDIDGDYR-- 67
Query: 67 AVSLTLGEIIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSL 126
+ +L I++ +S + + A Q ARK+LS ++NPP+ +I++G++P +V L+
Sbjct: 68 VQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDD 127
Query: 127 YPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGD 186
P LQFEAAWALTNIASGTSEQT+AVV+ A+ + LL S + VCEQAVWALGNI GD
Sbjct: 128 NPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGD 187
Query: 187 GPEFRDNVITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILPAL 246
GP+ RD VI+ + LL+ ISP++PITFLRN+TW + NLCR+K+P P +++ILPAL
Sbjct: 188 GPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPAL 247
Query: 247 LHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRT 306
L+ H D +L D WALSYLTD N++I V+++G++P LV L++ E+ V T +LR
Sbjct: 248 CVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRA 307
Query: 307 VGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAY 366
VGNIVTGTDEQTQ+ ++ L+ P LL H K I KEA W LSN+ AG +Q ++
Sbjct: 308 VGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDA 367
Query: 367 DVLPPLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPDVKI 426
+++P ++ LL G+F QKEA W ++N DQ+ L+ V+ P NLLT D ++
Sbjct: 368 NLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQV 427
Query: 427 VLIILDVISCILQAAEKRSEKENLCLLIEELGGIDRIEALQLHENRQIGQSALNIIEKHF 486
V ++LD +S IL+ AE E E + LIEE GG+++IE LQ HEN I + A II++ F
Sbjct: 428 VQVVLDGLSNILKMAE--DEAETIGNLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFF 485
Query: 487 GEEE-DESQTLLSQVI 501
++ DE +L+ + I
Sbjct: 486 SSDDIDEDPSLVPEAI 501
>gi|34485722 karyopherin alpha 3 [Homo sapiens]
Length = 521
Score = 427 bits (1099), Expect = e-120
Identities = 227/499 (45%), Positives = 322/499 (64%), Gaps = 5/499 (1%)
Query: 2 PTLDAPEERRRKFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNITSFCPDTPSEK 61
P+L+ R + FK +G+DV R+ R V++ELRK K+DE LK+RN+ S+
Sbjct: 5 PSLE--NHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDSDV 62
Query: 62 TAKGVAVSLTLGEIIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVEF 121
A A ++TL I++ S +PV+ A Q ARK+LS ++NPP+ +I++G++P +V+
Sbjct: 63 DADFKAQNVTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKC 122
Query: 122 LKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALG 181
L+ P LQFEAAWALTNIASGTS QT+AVV+ A+ + LL S + VCEQAVWALG
Sbjct: 123 LERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVWALG 182
Query: 182 NIAGDGPEFRDNVITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQ 241
NI GDGP+ RD VI+ + LL+ ISP++PITFLRN+TW + NLCRNK+P P V++
Sbjct: 183 NIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQE 242
Query: 242 ILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLT 301
ILPAL L+ H D +L D WALSYLTDG N++I V+++GV+P LV L++ E+ V T
Sbjct: 243 ILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQT 302
Query: 302 PSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQ 361
+LR VGNIVTGTDEQTQ+ ++ +L+ P LL H K I KEA W LSN+ AG +Q
Sbjct: 303 AALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQVQ 362
Query: 362 QLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTA 421
++ ++P ++ L G+F QKEA W ++N DQ+ LV V+ P NLL+
Sbjct: 363 AVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSV 422
Query: 422 PDVKIVLIILDVISCILQAAEKRSEKENLCLLIEELGGIDRIEALQLHENRQIGQSALNI 481
D ++V ++LD + IL A E + +IEE GG+++IE LQ HEN I + A I
Sbjct: 423 KDSQVVQVVLDGLKNILIMA--GDEASTIAEIIEECGGLEKIEVLQQHENEDIYKLAFEI 480
Query: 482 IEKHF-GEEEDESQTLLSQ 499
I+++F G++ DE L+ +
Sbjct: 481 IDQYFSGDDIDEDPCLIPE 499
>gi|222144293 karyopherin alpha 1 [Homo sapiens]
Length = 538
Score = 379 bits (972), Expect = e-105
Identities = 220/523 (42%), Positives = 308/523 (58%), Gaps = 19/523 (3%)
Query: 10 RRRKFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNITSFCPDTPSEKTAKG---- 65
R + +K + + R++R L+LRK K++EQ KRRN+ + +T E + G
Sbjct: 10 RLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHE 69
Query: 66 --------VAVSLTLGEIIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEA-GLIP 116
+ ++I+ + S P ATQ RK+LS+E NPP+ VI G++
Sbjct: 70 AQISNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTPGVVA 129
Query: 117 RMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQA 176
R VEFLK LQFE+AW LTNIASG S QTR V++ GA+ IELLSS V EQA
Sbjct: 130 RFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQA 189
Query: 177 VWALGNIAGDGPEFRDNVITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCD 236
VWALGNIAGD RD V+ N +P LL L S +T RN W LSNLCR K+P P
Sbjct: 190 VWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEF 249
Query: 237 TAVKQILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSE 296
V L L LL D++VL+DACWALSYL+DG N +I V++ GV RLV L+ ++
Sbjct: 250 AKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHND 309
Query: 297 LNVLTPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGP 356
V++P+LR VGNIVTG D QTQ+ ++ L L LL K SI+KEA W +SN+ AG
Sbjct: 310 YKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGN 369
Query: 357 CHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLV 416
IQ ++ ++ P L+++L+ EF+ +KEA W + N +G + +Q+ LV G ++PL
Sbjct: 370 RAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLC 429
Query: 417 NLLTAPDVKIVLIILDVISCILQAAEKRSEKEN-----LCLLIEELGGIDRIEALQLHEN 471
+LLT D KIV + L+ + IL+ E+ +++ C LIEE G+D+IE LQ HEN
Sbjct: 430 DLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIEFLQSHEN 489
Query: 472 RQIGQSALNIIEKHFGEEEDESQTLLSQVIDQDYEFIDYECLA 514
++I Q A ++IE +FG EDE ++ QV ++I +C A
Sbjct: 490 QEIYQKAFDLIEHYFG-TEDEDSSIAPQVDLNQQQYIFQQCEA 531
>gi|6912478 karyopherin alpha 6 [Homo sapiens]
Length = 536
Score = 378 bits (970), Expect = e-105
Identities = 222/524 (42%), Positives = 316/524 (60%), Gaps = 17/524 (3%)
Query: 1 MPTLDAPEE---RRRKFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNITSFCPDT 57
M T+ +P + R + +K + R++R ++LRK K+++Q KRRN+ +
Sbjct: 1 METMASPGKDNYRMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEA 60
Query: 58 PS-EKTAKGVAVSLTLGE------IIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVI 110
+ VS T GE +++ + S D L TQ RK+LS+E +PP+ VI
Sbjct: 61 AMFDSLLMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVI 120
Query: 111 EAG-LIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSN 169
++ R VEFLK + LQFEAAWALTNIASGTS+QT+ V+E GA+ IELL+S
Sbjct: 121 NTPRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDF 180
Query: 170 VAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALISPTLPITFLRNITWTLSNLCRN 229
V EQAVWALGNIAGD RD V+ + + LL L++ + +T RN W LSNLCR
Sbjct: 181 EDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRG 240
Query: 230 KNPYPCDTAVKQILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLV 289
KNP P V LP L LL DS++L+DACWALSYL+DG N++I V+++GV RLV
Sbjct: 241 KNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLV 300
Query: 290 VLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWAL 349
L+ ++ V +P+LR VGNIVTG D QTQ+ ++ L L LL K SI+KEA W +
Sbjct: 301 ELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTI 360
Query: 350 SNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHS 409
SN+ AG IQ ++ ++ P L+ +L+ EF+ +KEA W + N +G T +Q+ LV
Sbjct: 361 SNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSL 420
Query: 410 GVLEPLVNLLTAPDVKIVLIILDVISCILQAAEKRSEKEN-----LCLLIEELGGIDRIE 464
G ++PL +LLT D KIV + L+ + IL+ E+ ++ C LIEE G+D+IE
Sbjct: 421 GCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIE 480
Query: 465 ALQLHENRQIGQSALNIIEKHFGEEEDESQTLLSQVIDQDYEFI 508
LQ HEN++I Q A ++IE +FG E+D+S +L QV + +FI
Sbjct: 481 FLQSHENQEIYQKAFDLIEHYFGVEDDDS-SLAPQVDETQQQFI 523
>gi|39812229 karyopherin alpha 5 [Homo sapiens]
Length = 539
Score = 372 bits (954), Expect = e-103
Identities = 214/515 (41%), Positives = 311/515 (60%), Gaps = 17/515 (3%)
Query: 10 RRRKFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNI----------TSFCPDTPS 59
R + +K + + R++R ++LRK K++EQ KRRN+ S D
Sbjct: 13 RMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESMLESPIQDPDI 72
Query: 60 EKTAKGVAVSLTLGEIIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEA-GLIPRM 118
T + ++++ + S++ ATQ RK+LS+E NPP+ VI+ G++ R
Sbjct: 73 SSTVPIPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQVIQKPGVVQRF 132
Query: 119 VEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVW 178
V+FL+ + LQFEAAWALTNIASGT T+ V+E GA+ I+LL+S + V EQAVW
Sbjct: 133 VKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVW 192
Query: 179 ALGNIAGDGPEFRDNVITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTA 238
ALGNIAGD E RD V+ +P LL L++ + +T RN W LSNLCR KNP P +
Sbjct: 193 ALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSK 252
Query: 239 VKQILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELN 298
V L L LL D +VL+D CWALSYL+DG N +I V+++GV RLV L+ ++
Sbjct: 253 VSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYK 312
Query: 299 VLTPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCH 358
V++P+LR VGNIVTG D QTQ+ ++ L L LL K SI+KEA W +SN+ AG
Sbjct: 313 VVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITAGNRA 372
Query: 359 HIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNL 418
IQ ++ ++ P L+ +L+ EF+ +KEA W + N +G T +Q+ LV G ++PL +L
Sbjct: 373 QIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDL 432
Query: 419 LTAPDVKIVLIILDVISCILQAAEKRSEKENL-----CLLIEELGGIDRIEALQLHENRQ 473
LT D KIV + L+ + IL+ E+ S++ + C LIEE G+D+IE LQ HEN++
Sbjct: 433 LTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDKIEFLQSHENQE 492
Query: 474 IGQSALNIIEKHFGEEEDESQTLLSQVIDQDYEFI 508
I Q A ++IE +FG EED+ +++ QV + +FI
Sbjct: 493 IYQKAFDLIEHYFGVEEDD-PSIVPQVDENQQQFI 526
>gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens]
Length = 509
Score = 79.0 bits (193), Expect = 1e-14
Identities = 65/274 (23%), Positives = 124/274 (45%), Gaps = 5/274 (1%)
Query: 109 VIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSS 168
+++ G + +V L+ P ++ AAWAL IA +E ++AVV+ GA+ L+ +
Sbjct: 121 IVDCGALDTLVICLED-FDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEP 179
Query: 169 NVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALI-SPTLPITFLRNITWTLSNLC 227
+A+ A AL +IA PE V+ + A+ HL +I +P + I LS +
Sbjct: 180 EIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLK--HQILSALSQVS 237
Query: 228 RNKNPYPCDTAVKQILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPR 287
++ +I P +L L+ +D V +A + + + + VVN G +
Sbjct: 238 KHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAA 297
Query: 288 LVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQ-MAIDAGMLNVLPQLLQHNKPSIQKEAA 346
++ + S + N P + +G + ++ + I G+ + L + + I+ AA
Sbjct: 298 VIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAA 357
Query: 347 WALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGE 380
WAL + H + + + LP L++L + E
Sbjct: 358 WALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTE 391
Score = 58.5 bits (140), Expect = 1e-08
Identities = 53/253 (20%), Positives = 106/253 (41%), Gaps = 4/253 (1%)
Query: 145 TSEQTRAVVEGGAIQPLIELLSSSNVAVCEQ-AVWALGNIAGDGPEFRDNVITSNAIPHL 203
T Q ++ + L+ L V +Q A ALG +A + + V+ + +P L
Sbjct: 29 TRPQNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQL 88
Query: 204 LALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVK-QILPALLHLLQHQDSEVLSDAC 262
+ ++ F + + +P V L L+ L+ D V A
Sbjct: 89 VYSLAEQN--RFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAA 146
Query: 263 WALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAI 322
WAL Y+ + + VV+ G +P LV+ + E+ + + + +I + E Q +
Sbjct: 147 WALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVV 206
Query: 323 DAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFK 382
DAG + L Q++ + ++ + ALS V+ + ++ ++ P ++ LK+ +
Sbjct: 207 DAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEY 266
Query: 383 VQKEAVWMVANFA 395
V+K A ++ A
Sbjct: 267 VKKNASTLIREIA 279
Score = 58.2 bits (139), Expect = 2e-08
Identities = 70/307 (22%), Positives = 130/307 (42%), Gaps = 13/307 (4%)
Query: 89 QATQTARKMLSQEKNPPLKLVIEAGLIPRMVEFL--KSSLYPCLQFEAAWALTNIASGTS 146
Q A L+ + + V++ ++P++V L ++ Y + AA+ L + +
Sbjct: 59 QTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFY---KKAAAFVLRAVGKHSP 115
Query: 147 EQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLAL 206
+ +A+V+ GA+ L+ L + V E A WAL IA E V+ + A+P LL L
Sbjct: 116 QLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVP-LLVL 174
Query: 207 ISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQ---HQDSEVLSDACW 263
I R LS++ ++ +P T V A+ HL Q + D+++
Sbjct: 175 CIQEPEIALKRIAASALSDIAKH-SPELAQTVVD--AGAVAHLAQMILNPDAKLKHQILS 231
Query: 264 ALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAID 323
ALS ++ S VV + P ++ + + V + + I T E +Q+ ++
Sbjct: 232 ALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVN 291
Query: 324 AGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPL-VALLKNGEFK 382
AG + + + K + + L VAA + ++ +P L V L + E
Sbjct: 292 AGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDH 351
Query: 383 VQKEAVW 389
++ A W
Sbjct: 352 IKAAAAW 358
Score = 45.4 bits (106), Expect = 1e-04
Identities = 38/163 (23%), Positives = 65/163 (39%), Gaps = 1/163 (0%)
Query: 93 TARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAV 152
+A +S+ ++V+EA + P ++ LK ++ A+ + IA T E ++ V
Sbjct: 231 SALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDK-DEYVKKNASTLIREIAKHTPELSQLV 289
Query: 153 VEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALISPTLP 212
V G + +I+ + S + LG +A VI S +P L +S
Sbjct: 290 VNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPE 349
Query: 213 ITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQHQDS 255
W L + R+ + AV LP LL L +S
Sbjct: 350 DHIKAAAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTES 392
>gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens]
Length = 458
Score = 79.0 bits (193), Expect = 1e-14
Identities = 65/274 (23%), Positives = 124/274 (45%), Gaps = 5/274 (1%)
Query: 109 VIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSS 168
+++ G + +V L+ P ++ AAWAL IA +E ++AVV+ GA+ L+ +
Sbjct: 121 IVDCGALDTLVICLED-FDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEP 179
Query: 169 NVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALI-SPTLPITFLRNITWTLSNLC 227
+A+ A AL +IA PE V+ + A+ HL +I +P + I LS +
Sbjct: 180 EIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLK--HQILSALSQVS 237
Query: 228 RNKNPYPCDTAVKQILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPR 287
++ +I P +L L+ +D V +A + + + + VVN G +
Sbjct: 238 KHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAA 297
Query: 288 LVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQ-MAIDAGMLNVLPQLLQHNKPSIQKEAA 346
++ + S + N P + +G + ++ + I G+ + L + + I+ AA
Sbjct: 298 VIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAA 357
Query: 347 WALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGE 380
WAL + H + + + LP L++L + E
Sbjct: 358 WALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTE 391
Score = 58.5 bits (140), Expect = 1e-08
Identities = 53/253 (20%), Positives = 106/253 (41%), Gaps = 4/253 (1%)
Query: 145 TSEQTRAVVEGGAIQPLIELLSSSNVAVCEQ-AVWALGNIAGDGPEFRDNVITSNAIPHL 203
T Q ++ + L+ L V +Q A ALG +A + + V+ + +P L
Sbjct: 29 TRPQNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQL 88
Query: 204 LALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVK-QILPALLHLLQHQDSEVLSDAC 262
+ ++ F + + +P V L L+ L+ D V A
Sbjct: 89 VYSLAEQN--RFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAA 146
Query: 263 WALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAI 322
WAL Y+ + + VV+ G +P LV+ + E+ + + + +I + E Q +
Sbjct: 147 WALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVV 206
Query: 323 DAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFK 382
DAG + L Q++ + ++ + ALS V+ + ++ ++ P ++ LK+ +
Sbjct: 207 DAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEY 266
Query: 383 VQKEAVWMVANFA 395
V+K A ++ A
Sbjct: 267 VKKNASTLIREIA 279
Score = 58.2 bits (139), Expect = 2e-08
Identities = 70/307 (22%), Positives = 130/307 (42%), Gaps = 13/307 (4%)
Query: 89 QATQTARKMLSQEKNPPLKLVIEAGLIPRMVEFL--KSSLYPCLQFEAAWALTNIASGTS 146
Q A L+ + + V++ ++P++V L ++ Y + AA+ L + +
Sbjct: 59 QTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFY---KKAAAFVLRAVGKHSP 115
Query: 147 EQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLAL 206
+ +A+V+ GA+ L+ L + V E A WAL IA E V+ + A+P LL L
Sbjct: 116 QLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVP-LLVL 174
Query: 207 ISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQ---HQDSEVLSDACW 263
I R LS++ ++ +P T V A+ HL Q + D+++
Sbjct: 175 CIQEPEIALKRIAASALSDIAKH-SPELAQTVVD--AGAVAHLAQMILNPDAKLKHQILS 231
Query: 264 ALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAID 323
ALS ++ S VV + P ++ + + V + + I T E +Q+ ++
Sbjct: 232 ALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVN 291
Query: 324 AGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPL-VALLKNGEFK 382
AG + + + K + + L VAA + ++ +P L V L + E
Sbjct: 292 AGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDH 351
Query: 383 VQKEAVW 389
++ A W
Sbjct: 352 IKAAAAW 358
Score = 45.4 bits (106), Expect = 1e-04
Identities = 38/163 (23%), Positives = 65/163 (39%), Gaps = 1/163 (0%)
Query: 93 TARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAV 152
+A +S+ ++V+EA + P ++ LK ++ A+ + IA T E ++ V
Sbjct: 231 SALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDK-DEYVKKNASTLIREIAKHTPELSQLV 289
Query: 153 VEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALISPTLP 212
V G + +I+ + S + LG +A VI S +P L +S
Sbjct: 290 VNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPE 349
Query: 213 ITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQHQDS 255
W L + R+ + AV LP LL L +S
Sbjct: 350 DHIKAAAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTES 392
>gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens]
Length = 493
Score = 65.5 bits (158), Expect = 1e-10
Identities = 98/409 (23%), Positives = 173/409 (42%), Gaps = 62/409 (15%)
Query: 2 PTLDAPEERRRKFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNITSFCPDTPSEK 61
PT+ EE RR RR++R A LRKA++++Q + +R + + P+ E
Sbjct: 11 PTVCGVEELRR-----------RRREREAA---LRKARREQQLVSKRLLRNDAPEEAGEG 56
Query: 62 TAKGVAVSLTLGEIIKGVN-SSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVE 120
+ + + ++ ++ A + R+ L + + +E + R +
Sbjct: 57 CVAAILGETEVQQFLRQAQRGTEEKEREGALVSLRRGLQHPETQQTFIRLEGSM--RTLV 114
Query: 121 FLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWAL 180
L +S LQ EAA L + S + + T A A L+ LSS + E ++ L
Sbjct: 115 GLLTSNQALLQLEAARCLHEL-SHSEQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTL 173
Query: 181 GNIAGDGPEFRDNVITSNAIPHLLALI-SPTLPITFLRNITWTLSNLCRNKNPYPCDTAV 239
GN+ + R ++ +P L A I SP + + L + + LS L + + A
Sbjct: 174 GNLIVESEAVRRQLLPQGIVPALAACIQSPHVAV--LEALGYALSQLLQ------AEEAP 225
Query: 240 KQILPALL------HLLQ------HQDSEVLSDACWALSYL--TDGSNKRIGQVVNTGVL 285
++I+P++L H+LQ + V + W L Y+ + SN + + G L
Sbjct: 226 EKIIPSILASTLPQHMLQMLQPGPKLNPGVAVEFAWCLHYIICSQVSNPLL---IGHGAL 282
Query: 286 PRLVVLMTS----------SELNVLT-PSLRTVGNIVTGTDEQT---QMAID----AGML 327
L +L+ + L +L P LR + N++T +T QM + L
Sbjct: 283 STLGLLLLDLAGAVQKTEDAGLELLACPVLRCLSNLLTEAAVETVGGQMQLRDERVVAAL 342
Query: 328 NVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALL 376
+L Q +PS+ E W L+N+ A LL+ D++ PL+ LL
Sbjct: 343 FILLQFFFQKQPSLLPEGLWLLNNLTANSPSFCTSLLSLDLIEPLLQLL 391
Score = 41.2 bits (95), Expect = 0.002
Identities = 53/218 (24%), Positives = 86/218 (39%), Gaps = 21/218 (9%)
Query: 58 PSEKTAKGVAVSLT--LGEIIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLI 115
P K GVAV L II S+P+L + +L + ++ +AGL
Sbjct: 247 PGPKLNPGVAVEFAWCLHYIICS-QVSNPLLIGHGALSTLGLLLLDLAGAVQKTEDAGL- 304
Query: 116 PRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQ 175
E L + CL A G Q R A+ L++ ++ +
Sbjct: 305 ----ELLACPVLRCLSNLLTEAAVETVGGQM-QLRDERVVAALFILLQFFFQKQPSLLPE 359
Query: 176 AVWALGNIAGDGPEFRDNVITSNAIPHLLALISPT-----LPITFLRNITWTLSNLCRNK 230
+W L N+ + P F ++++ + I LL L+ + + +T L N+ C+
Sbjct: 360 GLWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPVSNVVSVMVLTVLCNVAEKGPAYCQRL 419
Query: 231 NPYPCDTAVKQILPALLHLLQHQDSEVLSDACWALSYL 268
P P +LPALLH L D+EV+ + L L
Sbjct: 420 WPGP-------LLPALLHTLAFSDTEVVGQSLELLHLL 450
Score = 37.4 bits (85), Expect = 0.033
Identities = 36/138 (26%), Positives = 60/138 (43%), Gaps = 5/138 (3%)
Query: 128 PCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDG 187
P L E W L N+ + + +++ I+PL++LL SNV V + L N+A G
Sbjct: 354 PSLLPEGLWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPVSNV-VSVMVLTVLCNVAEKG 412
Query: 188 PEFRDNVITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALL 247
P + + +P LL ++ T + + L +L P ++Q L
Sbjct: 413 PAYCQRLWPGPLLPALLHTLA--FSDTEVVGQSLELLHLLFLYQPEAVQVFLQQ--SGLQ 468
Query: 248 HLLQHQDSEVLSDACWAL 265
L +HQ+ L D +AL
Sbjct: 469 ALERHQEEAQLQDRVYAL 486
>gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens]
Length = 1363
Score = 61.6 bits (148), Expect = 2e-09
Identities = 77/317 (24%), Positives = 134/317 (42%), Gaps = 14/317 (4%)
Query: 107 KLVIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLS 166
+ +++AG IP ++ LKSS LQ + L+NI++ S A+VE G I LI LL
Sbjct: 665 RCILDAGTIPALINLLKSSKIK-LQCKTVGLLSNISTHKS-AVHALVEAGGIPSLINLLV 722
Query: 167 SSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALISPTLPITFLRNITWTLSNL 226
V + L +IA E +D + N IP L+ L++ + L N+ + L
Sbjct: 723 CDEPEVHSRCAVILYDIA--QCENKDVIAKYNGIPSLINLLNLNIE-NVLVNVMNCIRVL 779
Query: 227 CRNKNPYPCDTAVKQILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRI-GQVVNTGVL 285
C + LP L+ L DS+VL A NK I + G +
Sbjct: 780 CIGNENNQRAVREHKGLPYLIRFLS-SDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAI 838
Query: 286 PRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEA 345
P LV L +++V V ++ + + ++ + L +LL+ + ++++
Sbjct: 839 PPLVALFKGKQISVQMKGAMAVESLASHNALIQKAFLEKSLTKYLLKLLKAFQIDVKEQG 898
Query: 346 A---WALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATMDQ 402
A WAL+ ++ + + Y ++ +L + K+Q V + + M Q
Sbjct: 899 AVALWALAGQTLKQQKYMAEQIGYSF---IINMLLSPSAKMQYVGGEAVIALSKDSRMHQ 955
Query: 403 LIQLVHSGVLEPLVNLL 419
Q+ + PLV LL
Sbjct: 956 -NQICEGNGIAPLVRLL 971
Score = 45.8 bits (107), Expect = 9e-05
Identities = 56/250 (22%), Positives = 101/250 (40%), Gaps = 12/250 (4%)
Query: 115 IPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCE 174
+P ++ FL S L+ ++ A+ + E A+ GAI PL+ L ++V
Sbjct: 796 LPYLIRFLSSDS-DVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQM 854
Query: 175 QAVWALGNIAGDGPEFRDNVITSNAIPHLLALISPTLPITFLRN---ITWTLSNLCRNKN 231
+ A+ ++A + + + +LL L+ I W L+ +
Sbjct: 855 KGAMAVESLASHNALIQKAFLEKSLTKYLLKLLK-AFQIDVKEQGAVALWALAGQTLKQQ 913
Query: 232 PYPCDTAVKQILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVL 291
Y + + +L + V +A ALS + +I + L RL+ +
Sbjct: 914 KYMAEQIGYSFIINMLLSPSAKMQYVGGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRI 973
Query: 292 MTSSELNVLTPSLRTVGNIVTGTDEQT-----QMAIDAGMLNVLPQLLQ-HNKPSIQKEA 345
T +E L +R VG+I G + Q +D VL QLL+ H P+I+ E
Sbjct: 974 STIAE-GTLLSVIRAVGSICIGVAHTSNPVSQQFVVDENAFPVLIQLLRNHPSPNIKVEV 1032
Query: 346 AWALSNVAAG 355
A++L+ + G
Sbjct: 1033 AFSLACIVLG 1042
Score = 45.4 bits (106), Expect = 1e-04
Identities = 60/267 (22%), Positives = 113/267 (42%), Gaps = 7/267 (2%)
Query: 161 LIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALISPTLPITFLRNIT 220
L+E+L + AV +L I ++ ++ + IP L+ L+ + I
Sbjct: 634 LVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSS-KIKLQCKTV 692
Query: 221 WTLSNLCRNKNPYPCDTAVKQILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVV 280
LSN+ +K+ I P+L++LL + EV S L + NK + +
Sbjct: 693 GLLSNISTHKSAVHALVEAGGI-PSLINLLVCDEPEVHSRCAVILYDIAQCENKDV--IA 749
Query: 281 NTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPS 340
+P L+ L+ + NVL + + + G + + + L L + L +
Sbjct: 750 KYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPYLIRFLSSDSDV 809
Query: 341 IQKEAAWALSNVAAGPCHHIQQLLAYD-VLPPLVALLKNGEFKVQKEAVWMVANFATGAT 399
++ ++ A++ V IQ +A + +PPLVAL K + VQ + V + A+
Sbjct: 810 LKAVSSAAIAEVGRDN-KEIQDAIAMEGAIPPLVALFKGKQISVQMKGAMAVESLASHNA 868
Query: 400 MDQLIQLVHSGVLEPLVNLLTAPDVKI 426
+ Q L S + + L+ LL A + +
Sbjct: 869 LIQKAFLEKS-LTKYLLKLLKAFQIDV 894
Score = 37.0 bits (84), Expect = 0.043
Identities = 28/111 (25%), Positives = 56/111 (50%), Gaps = 6/111 (5%)
Query: 330 LPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVW 389
L ++LQ + A +L + + + +L +P L+ LLK+ + K+Q + V
Sbjct: 634 LVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVG 693
Query: 390 MVANFATGATMDQLIQLVHSGVLEPLVNLLTA--PDV--KIVLIILDVISC 436
+++N +T + + LV +G + L+NLL P+V + +I+ D+ C
Sbjct: 694 LLSNISTHKS--AVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQC 742
Score = 35.0 bits (79), Expect = 0.16
Identities = 31/128 (24%), Positives = 63/128 (49%), Gaps = 7/128 (5%)
Query: 310 IVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVL 369
I D+ + +DAG + L LL+ +K +Q + LSN++ + L+ +
Sbjct: 656 ICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVGLLSNISTHK-SAVHALVEAGGI 714
Query: 370 PPLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPDVKIVLI 429
P L+ LL E +V ++ + A D + + ++G+ L+NLL ++ I +
Sbjct: 715 PSLINLLVCDEPEVHSRCAVILYDIAQCENKDVIAK--YNGI-PSLINLL---NLNIENV 768
Query: 430 ILDVISCI 437
+++V++CI
Sbjct: 769 LVNVMNCI 776
>gi|148227672 catenin (cadherin-associated protein), beta 1, 88kDa
[Homo sapiens]
Length = 781
Score = 54.3 bits (129), Expect = 3e-07
Identities = 80/343 (23%), Positives = 142/343 (41%), Gaps = 44/343 (12%)
Query: 75 IIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSLYPCLQFEA 134
I++ + +++ V + T LS + L + ++G IP +V+ L S + L F A
Sbjct: 198 IVRTMQNTNDVETARCTAGTLHNLSHHREG-LLAIFKSGGIPALVKMLGSPVDSVL-FYA 255
Query: 135 AWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAV------CEQAVWALGN------ 182
L N+ AV G +Q ++ LL+ +NV C Q + A GN
Sbjct: 256 ITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQ-ILAYGNQESKLI 314
Query: 183 -IAGDGPEFRDNVITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQ 241
+A GP+ N++ + LL S L + ++C + P + Q
Sbjct: 315 ILASGGPQALVNIMRTYTYEKLLWTTSRVLKVL----------SVCSSNKPAIVEAGGMQ 364
Query: 242 ILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLT 301
L LHL ++ + W L L+D + K+ G G+L LV L+ S ++NV+T
Sbjct: 365 ALG--LHLTD-PSQRLVQNCLWTLRNLSDAATKQEGM---EGLLGTLVQLLGSDDINVVT 418
Query: 302 PSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQ--LLQHNKPSIQKEAAWALSNVAAGPCHH 359
+ + N+ + M G + L + L ++ I + A AL ++ + H
Sbjct: 419 CAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTS---RH 475
Query: 360 IQQLLAYDV------LPPLVALL-KNGEFKVQKEAVWMVANFA 395
+ +A + LP +V LL + + K V ++ N A
Sbjct: 476 QEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLA 518
Score = 31.6 bits (70), Expect = 1.8
Identities = 26/75 (34%), Positives = 34/75 (45%), Gaps = 2/75 (2%)
Query: 115 IPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCE 174
IP V+ L S + +Q AA L +A E A+ GA PL ELL S N V
Sbjct: 596 IPLFVQLLYSPIEN-IQRVAAGVLCELAQD-KEAAEAIEAEGATAPLTELLHSRNEGVAT 653
Query: 175 QAVWALGNIAGDGPE 189
A L ++ D P+
Sbjct: 654 YAAAVLFRMSEDKPQ 668
>gi|148233338 catenin (cadherin-associated protein), beta 1, 88kDa
[Homo sapiens]
Length = 781
Score = 54.3 bits (129), Expect = 3e-07
Identities = 80/343 (23%), Positives = 142/343 (41%), Gaps = 44/343 (12%)
Query: 75 IIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSLYPCLQFEA 134
I++ + +++ V + T LS + L + ++G IP +V+ L S + L F A
Sbjct: 198 IVRTMQNTNDVETARCTAGTLHNLSHHREG-LLAIFKSGGIPALVKMLGSPVDSVL-FYA 255
Query: 135 AWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAV------CEQAVWALGN------ 182
L N+ AV G +Q ++ LL+ +NV C Q + A GN
Sbjct: 256 ITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQ-ILAYGNQESKLI 314
Query: 183 -IAGDGPEFRDNVITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQ 241
+A GP+ N++ + LL S L + ++C + P + Q
Sbjct: 315 ILASGGPQALVNIMRTYTYEKLLWTTSRVLKVL----------SVCSSNKPAIVEAGGMQ 364
Query: 242 ILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLT 301
L LHL ++ + W L L+D + K+ G G+L LV L+ S ++NV+T
Sbjct: 365 ALG--LHLTD-PSQRLVQNCLWTLRNLSDAATKQEGM---EGLLGTLVQLLGSDDINVVT 418
Query: 302 PSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQ--LLQHNKPSIQKEAAWALSNVAAGPCHH 359
+ + N+ + M G + L + L ++ I + A AL ++ + H
Sbjct: 419 CAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTS---RH 475
Query: 360 IQQLLAYDV------LPPLVALL-KNGEFKVQKEAVWMVANFA 395
+ +A + LP +V LL + + K V ++ N A
Sbjct: 476 QEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLA 518
Score = 31.6 bits (70), Expect = 1.8
Identities = 26/75 (34%), Positives = 34/75 (45%), Gaps = 2/75 (2%)
Query: 115 IPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCE 174
IP V+ L S + +Q AA L +A E A+ GA PL ELL S N V
Sbjct: 596 IPLFVQLLYSPIEN-IQRVAAGVLCELAQD-KEAAEAIEAEGATAPLTELLHSRNEGVAT 653
Query: 175 QAVWALGNIAGDGPE 189
A L ++ D P+
Sbjct: 654 YAAAVLFRMSEDKPQ 668
>gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa
[Homo sapiens]
Length = 781
Score = 54.3 bits (129), Expect = 3e-07
Identities = 80/343 (23%), Positives = 142/343 (41%), Gaps = 44/343 (12%)
Query: 75 IIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSLYPCLQFEA 134
I++ + +++ V + T LS + L + ++G IP +V+ L S + L F A
Sbjct: 198 IVRTMQNTNDVETARCTAGTLHNLSHHREG-LLAIFKSGGIPALVKMLGSPVDSVL-FYA 255
Query: 135 AWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAV------CEQAVWALGN------ 182
L N+ AV G +Q ++ LL+ +NV C Q + A GN
Sbjct: 256 ITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQ-ILAYGNQESKLI 314
Query: 183 -IAGDGPEFRDNVITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQ 241
+A GP+ N++ + LL S L + ++C + P + Q
Sbjct: 315 ILASGGPQALVNIMRTYTYEKLLWTTSRVLKVL----------SVCSSNKPAIVEAGGMQ 364
Query: 242 ILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLT 301
L LHL ++ + W L L+D + K+ G G+L LV L+ S ++NV+T
Sbjct: 365 ALG--LHLTD-PSQRLVQNCLWTLRNLSDAATKQEGM---EGLLGTLVQLLGSDDINVVT 418
Query: 302 PSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQ--LLQHNKPSIQKEAAWALSNVAAGPCHH 359
+ + N+ + M G + L + L ++ I + A AL ++ + H
Sbjct: 419 CAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTS---RH 475
Query: 360 IQQLLAYDV------LPPLVALL-KNGEFKVQKEAVWMVANFA 395
+ +A + LP +V LL + + K V ++ N A
Sbjct: 476 QEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLA 518
Score = 31.6 bits (70), Expect = 1.8
Identities = 26/75 (34%), Positives = 34/75 (45%), Gaps = 2/75 (2%)
Query: 115 IPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCE 174
IP V+ L S + +Q AA L +A E A+ GA PL ELL S N V
Sbjct: 596 IPLFVQLLYSPIEN-IQRVAAGVLCELAQD-KEAAEAIEAEGATAPLTELLHSRNEGVAT 653
Query: 175 QAVWALGNIAGDGPE 189
A L ++ D P+
Sbjct: 654 YAAAVLFRMSEDKPQ 668
>gi|32526896 armadillo repeat containing 8 isoform 2 [Homo sapiens]
Length = 659
Score = 54.3 bits (129), Expect = 3e-07
Identities = 52/229 (22%), Positives = 102/229 (44%), Gaps = 9/229 (3%)
Query: 134 AAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPE-FRD 192
A+ L N+ S ++E GA++ L L S N A+ +WAL N+A + +
Sbjct: 432 ASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMAFQAEQKIKA 491
Query: 193 NVITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYP--CDTAVKQILPALLHLL 250
+++ S + L L+S + + L L NL + T KQI+ A+ +L
Sbjct: 492 DILRSLSTEQLFRLLSDS-DLNVLMKTLGLLRNLLSTRPHIDKIMSTHGKQIMQAVTLIL 550
Query: 251 QHQDS-EVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGN 309
+ + + EV L+ + DG+ + + N +L ++ M S + + ++ + N
Sbjct: 551 EGEHNIEVKEQTLCILANIADGTTAKDLIMTNDDILQKIKYYMGHSHVKLQLAAMFCISN 610
Query: 310 IV----TGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAA 354
++ G+ E+ D G++++L +L Q ++ +A AL A
Sbjct: 611 LIWNEEEGSQERQDKLRDMGIVDILHKLSQSPDSNLCDKAKMALQQYLA 659
Score = 39.3 bits (90), Expect = 0.009
Identities = 39/171 (22%), Positives = 76/171 (44%), Gaps = 8/171 (4%)
Query: 271 GSNKRIGQVVNTGVLPRLVVLM--TSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAGMLN 328
G+NK+ ++ G +PRL+ L+ +S + T +G++ GT+ + +D ++
Sbjct: 35 GNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIP 94
Query: 329 VLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYD--VLPPLVALLKNGEFKVQKE 386
L Q L + L + P ++LL D V+P L+ALL + +E
Sbjct: 95 ALLQGLLSPDLKFIEACLRCLRTIFTSPVTP-EELLYTDATVIPHLMALLSRSRY--TQE 151
Query: 387 AVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPDVKIVLIILDVISCI 437
+ + + Q I L + G ++ + +LLT+ K+ + L S +
Sbjct: 152 YICQIFSHCCKGPDHQTI-LFNHGAVQNIAHLLTSLSYKVRMQALKCFSVL 201
Score = 35.4 bits (80), Expect = 0.13
Identities = 40/214 (18%), Positives = 89/214 (41%), Gaps = 14/214 (6%)
Query: 286 PRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEA 345
P + VL + + +L + + N++ + +++G + +L L Q P+++
Sbjct: 416 PLMKVLQNAPD-EILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNG 474
Query: 346 AWALSNVAAGPCHHIQQLLAYDVL-----PPLVALLKNGEFKVQKEAVWMVANFATGATM 400
WAL N+A +Q + D+L L LL + + V + + ++ N +
Sbjct: 475 IWALMNMA----FQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPH 530
Query: 401 DQLIQLVHSGVLEPLVNLLTAPDVKIVLIILDVISCILQAAEKRSEKENLCLLIEELGGI 460
I H + V L+ + I + + CIL + ++L + +++ +
Sbjct: 531 IDKIMSTHGKQIMQAVTLILEGEHNIE--VKEQTLCILANIADGTTAKDLIMTNDDI--L 586
Query: 461 DRIEALQLHENRQIGQSALNIIEKHFGEEEDESQ 494
+I+ H + ++ +A+ I EE+ SQ
Sbjct: 587 QKIKYYMGHSHVKLQLAAMFCISNLIWNEEEGSQ 620
>gi|189409124 armadillo repeat containing 3 [Homo sapiens]
Length = 872
Score = 52.8 bits (125), Expect = 8e-07
Identities = 100/459 (21%), Positives = 182/459 (39%), Gaps = 58/459 (12%)
Query: 13 KFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNITSFCPDTPSEKTAKGVAVSL-T 71
KF +G++ + AV L K E + RRN T S K + L
Sbjct: 51 KFALKGEENKTTLLELGAVE-PLTKLLTHEDKIVRRNATMIFGILASNNDVKKLLRELDV 109
Query: 72 LGEIIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSLYPCLQ 131
+ +I + + V+ + +S E +++ GL P + L SS P ++
Sbjct: 110 MNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIR--LLSSPDPDVK 167
Query: 132 FEAAWALTNIASGTSEQTRAVV-EGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEF 190
+ + N+ Q RA + E AI P+++LL S + A+ LG IA D E
Sbjct: 168 KNSMECIYNLVQDF--QCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIAND-KES 224
Query: 191 RDNVITSNAIPHL----------------LALISPTLP-----------------ITFLR 217
R + + + HL LA+I+ L ++F
Sbjct: 225 RTMLRDNQGLDHLIKILETKELNDLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAE 284
Query: 218 NITWTLSNLCRN------KNPYPCDTAV----KQILPALLHLLQHQDSEVLSDACWALSY 267
N T + ++ +N K Y + +++ L+ LL ++ A A+S
Sbjct: 285 NST--IPDIQKNAAKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISA 342
Query: 268 LTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAGML 327
+ + S + N +P+L+ L+ S V + + N+ T A +A +
Sbjct: 343 MCENSGSK--DFFNNQGIPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGI 400
Query: 328 NVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEA 387
+ L LL + AA L+N+A + + +D++ +++ L++ VQ +A
Sbjct: 401 DPLINLLSSKRDGAIANAATVLTNMAMQEPLRLN-IQNHDIMHAIISPLRSANTVVQSKA 459
Query: 388 VWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPDVKI 426
V AT ++ +L +SG LEPLV LL + + ++
Sbjct: 460 ALAVT--ATACDVEARTELRNSGGLEPLVELLRSKNDEV 496
Score = 45.8 bits (107), Expect = 9e-05
Identities = 37/165 (22%), Positives = 79/165 (47%), Gaps = 6/165 (3%)
Query: 288 LVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAW 347
+V+++ S E +L + + +E ++ G + L +LL H +++ A
Sbjct: 30 VVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNATM 89
Query: 348 ALSNVAAGPCHHIQQLLA-YDVLPPLVA-LLKNGEFKVQKEAVWMVANFATGATMDQLIQ 405
+A+ + +++LL DV+ ++A L E + + A +AN + T +Q
Sbjct: 90 IFGILASN--NDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSK--VQ 145
Query: 406 LVHSGVLEPLVNLLTAPDVKIVLIILDVISCILQAAEKRSEKENL 450
+ G LEPL+ LL++PD + ++ I ++Q + R++ + L
Sbjct: 146 IFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCRAKLQEL 190
Score = 44.7 bits (104), Expect = 2e-04
Identities = 49/234 (20%), Positives = 103/234 (44%), Gaps = 9/234 (3%)
Query: 249 LLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVG 308
+L + E+L+ AC A+ + ++ G + L L+T + V + G
Sbjct: 33 MLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNATMIFG 92
Query: 309 NIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDV 368
+ + D + + M +V+ QL + I + A+ L+N++A + Q+ +
Sbjct: 93 ILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKV-QIFEHGG 151
Query: 369 LPPLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPDVKIVL 428
L PL+ LL + + V+K ++ + N +Q +++ + P+++LL + I L
Sbjct: 152 LEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCRAKLQELNA--IPPILDLLKSEYPVIQL 209
Query: 429 IILDVISCILQAAEKRSEKENLCLLIEELGGIDRIEALQLHENRQIGQSALNII 482
+ L + I ++KE+ +L + G I+ L+ E + AL +I
Sbjct: 210 LALKTLGVI------ANDKESRTMLRDNQGLDHLIKILETKELNDLHIEALAVI 257
Score = 43.9 bits (102), Expect = 4e-04
Identities = 57/192 (29%), Positives = 77/192 (40%), Gaps = 25/192 (13%)
Query: 115 IPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCE 174
IP++++ LKS + AA AL N+ + A E I PLI LLSS
Sbjct: 358 IPQLIQLLKSDNEEVRE-AAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIA 416
Query: 175 QAVWALGNIAGDGPEFRDNVITSNAIPHLLALISPTLPITFLRNI-TWTLSNLCRNKNPY 233
A L N+A P R N I ++ I H A+ISP LR+ T S
Sbjct: 417 NAATVLTNMAMQEP-LRLN-IQNHDIMH--AIISP------LRSANTVVQSKAALAVTAT 466
Query: 234 PCDTAVKQI------LPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPR 287
CD + L L+ LL+ ++ EV A WA+ G + L R
Sbjct: 467 ACDVEARTELRNSGGLEPLVELLRSKNDEVRKHASWAVMVCA-------GDELTANELCR 519
Query: 288 LVVLMTSSELNV 299
L L E+NV
Sbjct: 520 LGALDILEEVNV 531
Score = 41.2 bits (95), Expect = 0.002
Identities = 84/411 (20%), Positives = 148/411 (36%), Gaps = 89/411 (21%)
Query: 96 KMLSQEKNPPLK-----LVIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTR 150
K + +E PP K L+IE+ +V L S L +A A+ A E
Sbjct: 3 KKIKKEVEPPPKDVFDPLMIESKKAATVVLMLNSPEEEILA-KACEAIYKFALKGEENKT 61
Query: 151 AVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALISPT 210
++E GA++PL +LL+ + V A G +A + + + + + + ++A ++P
Sbjct: 62 TLLELGAVEPLTKLLTHEDKIVRRNATMIFGILASNN-DVKKLLRELDVMNSVIAQLAPE 120
Query: 211 LPITFLRNITWTLSNLCR----------------------------NKNPYPCDTAVKQ- 241
+ + L+N+ KN C + Q
Sbjct: 121 EEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQD 180
Query: 242 -----------ILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVV 290
+P +L LL+ + + A L + + R N G L L+
Sbjct: 181 FQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIANDKESRTMLRDNQG-LDHLIK 239
Query: 291 LMTSSELNVL-TPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWAL 349
++ + ELN L +L + N + D Q+ G+ +L P IQK AA A+
Sbjct: 240 ILETKELNDLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAI 299
Query: 350 SNVAAGP----CHHIQQLLAYDV-----------------------------------LP 370
+ A P H Q++ V +P
Sbjct: 300 TKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSGSKDFFNNQGIP 359
Query: 371 PLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTA 421
L+ LLK+ +V++ A +AN T + G+ +PL+NLL++
Sbjct: 360 QLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGI-DPLINLLSS 409
Score = 40.4 bits (93), Expect = 0.004
Identities = 75/342 (21%), Positives = 141/342 (41%), Gaps = 13/342 (3%)
Query: 75 IIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSLYPCLQFEA 134
I+ + S PV+ A +T +++ +K L GL +++ L++ L EA
Sbjct: 196 ILDLLKSEYPVIQLLALKTLG-VIANDKESRTMLRDNQGL-DHLIKILETKELNDLHIEA 253
Query: 135 AWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVA-VCEQAVWALGNIAGDGPEFRDN 193
+ N + + + G ++ L+ +S + + + A A+ A D PE R
Sbjct: 254 LAVIANCLEDMDTMVQ-IQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYD-PENRKL 311
Query: 194 VITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQHQ 253
L+AL+ T + + +S +C N D Q +P L+ LL+
Sbjct: 312 FHEQEVEKCLVALLGSENDGTKIA-ASQAISAMCENSGSK--DFFNNQGIPQLIQLLKSD 368
Query: 254 DSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTG 313
+ EV A AL+ LT + + L+ L++S + + + N+
Sbjct: 369 NEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIANAATVLTNMAM- 427
Query: 314 TDEQTQMAI-DAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPL 372
E ++ I + +++ + L+ +Q +AA A++ A +L L PL
Sbjct: 428 -QEPLRLNIQNHDIMHAIISPLRSANTVVQSKAALAVTATACD-VEARTELRNSGGLEPL 485
Query: 373 VALLKNGEFKVQKEAVWMVANFA-TGATMDQLIQLVHSGVLE 413
V LL++ +V+K A W V A T ++L +L +LE
Sbjct: 486 VELLRSKNDEVRKHASWAVMVCAGDELTANELCRLGALDILE 527
>gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5
[Homo sapiens]
Length = 558
Score = 52.0 bits (123), Expect = 1e-06
Identities = 64/311 (20%), Positives = 136/311 (43%), Gaps = 22/311 (7%)
Query: 153 VEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALIS---P 209
V+ G I PL++LL+S + V Q ALGNI D + +I IP L+ L+
Sbjct: 86 VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVKLLGIHCQ 145
Query: 210 TLPITFLRNITW-TLSNLCRNKNPYPCDTAVKQILPALLHLLQHQDSEVLSDACWALSYL 268
+T + + + L+ L +K + ++++ ++H E++ + L+ L
Sbjct: 146 NAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFE---VLAPL 202
Query: 269 TDGSNKRIGQVVNTGVLPRLVVLM---TSSELNVLTPSLRTVGNIVTGT---DEQTQMAI 322
+ ++ Q+V G++ L+ ++ S+ L+T +++ DE Q
Sbjct: 203 AENDAIKL-QLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLF 261
Query: 323 DAGMLNVLPQLLQ---HNKPSIQKEAAWALSNVA---AGPCHHIQQLLAYDVLPPLVALL 376
+ G +V ++L N +Q A A++N A A H + + ++ L +
Sbjct: 262 EGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRHV 321
Query: 377 KNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPDVKIVLIILDVISC 436
++G VQ A+ + N A + +++ +GV E ++ L + + +L +
Sbjct: 322 EDGNVTVQHAALSALRNLA--IPVINKAKMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRM 379
Query: 437 ILQAAEKRSEK 447
++ A + +E+
Sbjct: 380 LIDAQAEAAEQ 390
>gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4
[Homo sapiens]
Length = 559
Score = 52.0 bits (123), Expect = 1e-06
Identities = 64/311 (20%), Positives = 136/311 (43%), Gaps = 22/311 (7%)
Query: 153 VEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALIS---P 209
V+ G I PL++LL+S + V Q ALGNI D + +I IP L+ L+
Sbjct: 87 VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVKLLGIHCQ 146
Query: 210 TLPITFLRNITW-TLSNLCRNKNPYPCDTAVKQILPALLHLLQHQDSEVLSDACWALSYL 268
+T + + + L+ L +K + ++++ ++H E++ + L+ L
Sbjct: 147 NAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFE---VLAPL 203
Query: 269 TDGSNKRIGQVVNTGVLPRLVVLM---TSSELNVLTPSLRTVGNIVTGT---DEQTQMAI 322
+ ++ Q+V G++ L+ ++ S+ L+T +++ DE Q
Sbjct: 204 AENDAIKL-QLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLF 262
Query: 323 DAGMLNVLPQLLQ---HNKPSIQKEAAWALSNVA---AGPCHHIQQLLAYDVLPPLVALL 376
+ G +V ++L N +Q A A++N A A H + + ++ L +
Sbjct: 263 EGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRHV 322
Query: 377 KNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPDVKIVLIILDVISC 436
++G VQ A+ + N A + +++ +GV E ++ L + + +L +
Sbjct: 323 EDGNVTVQHAALSALRNLA--IPVINKAKMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRM 380
Query: 437 ILQAAEKRSEK 447
++ A + +E+
Sbjct: 381 LIDAQAEAAEQ 391
>gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3
[Homo sapiens]
Length = 607
Score = 48.1 bits (113), Expect = 2e-05
Identities = 66/287 (22%), Positives = 117/287 (40%), Gaps = 26/287 (9%)
Query: 153 VEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSN----AIPHLLALIS 208
V+ G I PL++LL+S + V Q ALGNI D E R V + I HL +L S
Sbjct: 86 VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCS 145
Query: 209 PTLPIT--FLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQ-HQDSEVLSDACW-A 264
T P L L N + ++P L+ LL H + L++ C A
Sbjct: 146 ITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVA 205
Query: 265 LSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDA 324
L + + + Q +T + LV L + + V + D ++A
Sbjct: 206 FGNLAELESSK-EQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEA 264
Query: 325 GMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYD------------VLPPL 372
G++ L +++Q S +++ ++ + G + LL + V +
Sbjct: 265 GLVECLLEIVQQKVDSDKED---DITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRV 321
Query: 373 VALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLL 419
++ + + ++Q +ANFA I +V +G++E L++LL
Sbjct: 322 LSWIPSNNHQLQLAGALAIANFARNDA--NCIHMVDNGIVEKLMDLL 366
>gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2
[Homo sapiens]
Length = 607
Score = 48.1 bits (113), Expect = 2e-05
Identities = 66/287 (22%), Positives = 117/287 (40%), Gaps = 26/287 (9%)
Query: 153 VEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSN----AIPHLLALIS 208
V+ G I PL++LL+S + V Q ALGNI D E R V + I HL +L S
Sbjct: 87 VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCS 146
Query: 209 PTLPIT--FLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQ-HQDSEVLSDACW-A 264
T P L L N + ++P L+ LL H + L++ C A
Sbjct: 147 ITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVA 206
Query: 265 LSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDA 324
L + + + Q +T + LV L + + V + D ++A
Sbjct: 207 FGNLAELESSK-EQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEA 265
Query: 325 GMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYD------------VLPPL 372
G++ L +++Q S +++ ++ + G + LL + V +
Sbjct: 266 GLVECLLEIVQQKVDSDKED---DITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRV 322
Query: 373 VALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLL 419
++ + + ++Q +ANFA I +V +G++E L++LL
Sbjct: 323 LSWIPSNNHQLQLAGALAIANFARNDA--NCIHMVDNGIVEKLMDLL 367
>gi|155030192 RAP1, GTP-GDP dissociation stimulator 1 isoform 1
[Homo sapiens]
Length = 608
Score = 48.1 bits (113), Expect = 2e-05
Identities = 66/287 (22%), Positives = 117/287 (40%), Gaps = 26/287 (9%)
Query: 153 VEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSN----AIPHLLALIS 208
V+ G I PL++LL+S + V Q ALGNI D E R V + I HL +L S
Sbjct: 87 VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCS 146
Query: 209 PTLPIT--FLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQ-HQDSEVLSDACW-A 264
T P L L N + ++P L+ LL H + L++ C A
Sbjct: 147 ITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVA 206
Query: 265 LSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDA 324
L + + + Q +T + LV L + + V + D ++A
Sbjct: 207 FGNLAELESSK-EQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEA 265
Query: 325 GMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYD------------VLPPL 372
G++ L +++Q S +++ ++ + G + LL + V +
Sbjct: 266 GLVECLLEIVQQKVDSDKED---DITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRV 322
Query: 373 VALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLL 419
++ + + ++Q +ANFA I +V +G++E L++LL
Sbjct: 323 LSWIPSNNHQLQLAGALAIANFARNDA--NCIHMVDNGIVEKLMDLL 367
>gi|53829376 plakophilin 4 isoform b [Homo sapiens]
Length = 1149
Score = 43.9 bits (102), Expect = 4e-04
Identities = 41/136 (30%), Positives = 61/136 (44%), Gaps = 11/136 (8%)
Query: 243 LPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTP 302
LP ++H+LQHQ V ++A L +L G NK +V G + LV L+ L V
Sbjct: 530 LPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKN 589
Query: 303 SLRTVGNIVTG--TDEQTQMAIDAGMLNV--LPQLLQHNKPSIQKEAAWALSNVA--AGP 356
+ + N+V G TDE M NV +P LL+ + SI E ++ V
Sbjct: 590 ACGALRNLVFGKSTDEN-----KIAMKNVGGIPALLRLLRKSIDAEVRELVTGVLWNLSS 644
Query: 357 CHHIQQLLAYDVLPPL 372
C ++ + D L L
Sbjct: 645 CDAVKMTIIRDALSTL 660
Score = 31.6 bits (70), Expect = 1.8
Identities = 25/98 (25%), Positives = 43/98 (43%), Gaps = 3/98 (3%)
Query: 200 IPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQHQDSEVLS 259
+P ++ ++ P + N L +LC N + + L+ LL H+ EV
Sbjct: 530 LPEVIHMLQHQFP-SVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQK 588
Query: 260 DACWALSYLTDGSNKRIGQVV--NTGVLPRLVVLMTSS 295
+AC AL L G + ++ N G +P L+ L+ S
Sbjct: 589 NACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKS 626
>gi|53829374 plakophilin 4 isoform a [Homo sapiens]
Length = 1192
Score = 43.9 bits (102), Expect = 4e-04
Identities = 41/136 (30%), Positives = 61/136 (44%), Gaps = 11/136 (8%)
Query: 243 LPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTP 302
LP ++H+LQHQ V ++A L +L G NK +V G + LV L+ L V
Sbjct: 530 LPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKN 589
Query: 303 SLRTVGNIVTG--TDEQTQMAIDAGMLNV--LPQLLQHNKPSIQKEAAWALSNVA--AGP 356
+ + N+V G TDE M NV +P LL+ + SI E ++ V
Sbjct: 590 ACGALRNLVFGKSTDEN-----KIAMKNVGGIPALLRLLRKSIDAEVRELVTGVLWNLSS 644
Query: 357 CHHIQQLLAYDVLPPL 372
C ++ + D L L
Sbjct: 645 CDAVKMTIIRDALSTL 660
Score = 31.6 bits (70), Expect = 1.8
Identities = 25/98 (25%), Positives = 43/98 (43%), Gaps = 3/98 (3%)
Query: 200 IPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQHQDSEVLS 259
+P ++ ++ P + N L +LC N + + L+ LL H+ EV
Sbjct: 530 LPEVIHMLQHQFP-SVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQK 588
Query: 260 DACWALSYLTDGSNKRIGQVV--NTGVLPRLVVLMTSS 295
+AC AL L G + ++ N G +P L+ L+ S
Sbjct: 589 NACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKS 626
>gi|155030202 RAP1, GTP-GDP dissociation stimulator 1 isoform 6
[Homo sapiens]
Length = 516
Score = 43.5 bits (101), Expect = 5e-04
Identities = 64/302 (21%), Positives = 119/302 (39%), Gaps = 47/302 (15%)
Query: 153 VEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALISPTLP 212
V+ G I PL++LL+S + V Q ALGNI D ++ ++N L+ L +
Sbjct: 87 VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSQSSKEQFASTNIAEELVKLFKKQIE 146
Query: 213 ITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQHQ-DSEVLSDACWALSYLTDG 271
I L+ L N + ++ LL ++Q + DS+ D
Sbjct: 147 HDKREMIFEVLAPLAEN-DAIKLQLVEAGLVECLLEIVQQKVDSDKEDD----------- 194
Query: 272 SNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAGMLNVLP 331
+ L T S+L VL ++ G DE Q + G +V
Sbjct: 195 ----------------ITELKTGSDLMVL---------LLLG-DESMQKLFEGGKGSVFQ 228
Query: 332 QLLQ---HNKPSIQKEAAWALSNVA---AGPCHHIQQLLAYDVLPPLVALLKNGEFKVQK 385
++L N +Q A A++N A A H + + ++ L +++G VQ
Sbjct: 229 RVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRHVEDGNVTVQH 288
Query: 386 EAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPDVKIVLIILDVISCILQAAEKRS 445
A+ + N A + +++ +GV E ++ L + + +L + ++ A + +
Sbjct: 289 AALSALRNLA--IPVINKAKMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRMLIDAQAEAA 346
Query: 446 EK 447
E+
Sbjct: 347 EQ 348
>gi|90669931 tetratricopeptide repeat domain 12 [Homo sapiens]
Length = 705
Score = 42.0 bits (97), Expect = 0.001
Identities = 54/236 (22%), Positives = 95/236 (40%), Gaps = 10/236 (4%)
Query: 167 SSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALISPTLP-ITFLRNITWTLSN 225
SS+ A+C Q + +GN++ + R L+L++ + R + +TL
Sbjct: 443 SSSSALC-QCIAIMGNLSAEPTTRRHMAACEEFGDGCLSLLARCEEDVDLFREVIYTLLG 501
Query: 226 LCRN---KNPYPCDTAVKQILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNT 282
L N + P+ + ++ L LL QD +L+ A LS S K + + +
Sbjct: 502 LMMNLCLQAPFVSEVWAVEVSRRCLSLLNSQDGGILTRAAGVLSRTLSSSLKIVEEALRA 561
Query: 283 GVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAG-MLNVLPQLLQHNKPSI 341
GV+ +++ + + +++ + E + I L+V+ +LL +
Sbjct: 562 GVVKKMMKFLKTGGETASRYAIKILAICTNSYHEAREEVIRLDKKLSVMMKLLSSEDEVL 621
Query: 342 QKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATG 397
AA L N P + LL D+L LLK QK AV + A A G
Sbjct: 622 VGNAALCLGNCMEVP-NVASSLLKTDLLQ---VLLKLAGSDTQKTAVQVNAGIALG 673
>gi|31657114 armadillo repeat containing 4 [Homo sapiens]
Length = 1044
Score = 42.0 bits (97), Expect = 0.001
Identities = 65/294 (22%), Positives = 112/294 (38%), Gaps = 57/294 (19%)
Query: 138 LTNIASGTSE-----QTRAVVEG-GAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFR 191
L N+ E + R +V G IQPL+ LL N A+ A+G A +
Sbjct: 773 LVNVVGALGECCQERENRVIVRKCGGIQPLVNLLVGINQALLVNVTKAVGACAVE----- 827
Query: 192 DNVITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQ 251
P + +I + L W+L KNP+P
Sbjct: 828 ---------PESMMIIDRLDGVRLL----WSLL-----KNPHP----------------- 852
Query: 252 HQDSEVLSDACWALSYLTDGSNKRIGQVVNT--GVLPRLVVLMTSSELNVLTPSLRTVGN 309
+V + A WAL + K G++V + G L +V L+ S VL + N
Sbjct: 853 ----DVKASAAWALCPCIKNA-KDAGEMVRSFVGGLELIVNLLKSDNKEVLASVCAAITN 907
Query: 310 IVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVL 369
I E + D G++ +L +L N ++ A A+S + + + +
Sbjct: 908 IAK-DQENLAVITDHGVVPLLSKLANTNNNKLRHHLAEAISRCCMWGRNRV-AFGEHKAV 965
Query: 370 PPLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPD 423
PLV LK+ + V + + + A D I + +G ++ L++++ +PD
Sbjct: 966 APLVRYLKSNDTNVHRATAQALYQLSEDA--DNCITMHENGAVKLLLDMVGSPD 1017
>gi|4504811 junction plakoglobin [Homo sapiens]
Length = 745
Score = 40.4 bits (93), Expect = 0.004
Identities = 88/409 (21%), Positives = 154/409 (37%), Gaps = 70/409 (17%)
Query: 72 LGEIIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLIPR-MVEFLKSSLYPCL 130
L +++ +N ++P F A T L N KL+I A P+ +V+ +++ Y L
Sbjct: 270 LQKMVPLLNKNNPK--FLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKL 327
Query: 131 QFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEF 190
+ + L + S A+VE G +Q L + L+S++ + + +W L N++
Sbjct: 328 LWTTSRVL-KVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS------ 380
Query: 191 RDNVITSNAIPHLLALISPTL---PITFLRNITWTLSNL----CRNKNPYPCDTAVKQIL 243
D + +L ++ L + L T TLSNL +NK ++ V+ ++
Sbjct: 381 -DVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALI 439
Query: 244 PALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPS 303
A+L D + A AL +LT P + S LN P+
Sbjct: 440 HAILRAGDKDD--ITEPAVCALRHLTSRH-------------PEAEMAQNSVRLNYGIPA 484
Query: 304 LRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQL 363
++ L Q N+ + K + N+A P +H L
Sbjct: 485 -------------------------IVKLLNQPNQWPLVKATIGLIRNLALCPANH-APL 518
Query: 364 LAYDVLPPLVALLKNGEFKVQKE-AVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAP 422
V+P LV LL Q+ A + G M+++++ G L L P
Sbjct: 519 QEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVE----GCTGALHILARDP 574
Query: 423 DVKIVLIILDVISCILQAAEKRSEKEN------LCLLIEELGGIDRIEA 465
++ + L+ I +Q E LC L ++ D I+A
Sbjct: 575 MNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDA 623
Score = 35.0 bits (79), Expect = 0.16
Identities = 48/230 (20%), Positives = 89/230 (38%), Gaps = 4/230 (1%)
Query: 194 VITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQHQ 253
+ S IP L+ ++S + IT TL NL + + L ++ LL
Sbjct: 222 IFKSGGIPALVRMLSSPVESVLFYAIT-TLHNLLLYQEGAKMAVRLADGLQKMVPLLNKN 280
Query: 254 DSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTG 313
+ + L+ L L G+ + ++ G LV +M + L + V +++
Sbjct: 281 NPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSV 340
Query: 314 TDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLV 373
++AG + L + L N P + + W L N++ +Q VL LV
Sbjct: 341 CPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVA---TKQEGLESVLKILV 397
Query: 374 ALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPD 423
L + V A ++N + ++ + +SGV + +L A D
Sbjct: 398 NQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGD 447
Score = 33.1 bits (74), Expect = 0.62
Identities = 31/98 (31%), Positives = 44/98 (44%), Gaps = 6/98 (6%)
Query: 109 VIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSS 168
+ IP V+ L SS+ +Q AA L +A E A+ GA PL+ELL S
Sbjct: 580 IFRLNTIPLFVQLLYSSVEN-IQRVAAGVLCELAQD-KEAADAIDAEGASAPLMELLHSR 637
Query: 169 NVAVCEQAVWALGNIAGD-GPEFRDNV---ITSNAIPH 202
N A L I+ D P++R V +T++ H
Sbjct: 638 NEGTATYAAAVLFRISEDKNPDYRKRVSVELTNSLFKH 675
>gi|12056468 junction plakoglobin [Homo sapiens]
Length = 745
Score = 40.4 bits (93), Expect = 0.004
Identities = 88/409 (21%), Positives = 154/409 (37%), Gaps = 70/409 (17%)
Query: 72 LGEIIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLIPR-MVEFLKSSLYPCL 130
L +++ +N ++P F A T L N KL+I A P+ +V+ +++ Y L
Sbjct: 270 LQKMVPLLNKNNPK--FLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKL 327
Query: 131 QFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEF 190
+ + L + S A+VE G +Q L + L+S++ + + +W L N++
Sbjct: 328 LWTTSRVL-KVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS------ 380
Query: 191 RDNVITSNAIPHLLALISPTL---PITFLRNITWTLSNL----CRNKNPYPCDTAVKQIL 243
D + +L ++ L + L T TLSNL +NK ++ V+ ++
Sbjct: 381 -DVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALI 439
Query: 244 PALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPS 303
A+L D + A AL +LT P + S LN P+
Sbjct: 440 HAILRAGDKDD--ITEPAVCALRHLTSRH-------------PEAEMAQNSVRLNYGIPA 484
Query: 304 LRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQL 363
++ L Q N+ + K + N+A P +H L
Sbjct: 485 -------------------------IVKLLNQPNQWPLVKATIGLIRNLALCPANH-APL 518
Query: 364 LAYDVLPPLVALLKNGEFKVQKE-AVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAP 422
V+P LV LL Q+ A + G M+++++ G L L P
Sbjct: 519 QEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVE----GCTGALHILARDP 574
Query: 423 DVKIVLIILDVISCILQAAEKRSEKEN------LCLLIEELGGIDRIEA 465
++ + L+ I +Q E LC L ++ D I+A
Sbjct: 575 MNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDA 623
Score = 35.0 bits (79), Expect = 0.16
Identities = 48/230 (20%), Positives = 89/230 (38%), Gaps = 4/230 (1%)
Query: 194 VITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQHQ 253
+ S IP L+ ++S + IT TL NL + + L ++ LL
Sbjct: 222 IFKSGGIPALVRMLSSPVESVLFYAIT-TLHNLLLYQEGAKMAVRLADGLQKMVPLLNKN 280
Query: 254 DSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTG 313
+ + L+ L L G+ + ++ G LV +M + L + V +++
Sbjct: 281 NPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSV 340
Query: 314 TDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLV 373
++AG + L + L N P + + W L N++ +Q VL LV
Sbjct: 341 CPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVA---TKQEGLESVLKILV 397
Query: 374 ALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPD 423
L + V A ++N + ++ + +SGV + +L A D
Sbjct: 398 NQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGD 447
Score = 33.1 bits (74), Expect = 0.62
Identities = 31/98 (31%), Positives = 44/98 (44%), Gaps = 6/98 (6%)
Query: 109 VIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSS 168
+ IP V+ L SS+ +Q AA L +A E A+ GA PL+ELL S
Sbjct: 580 IFRLNTIPLFVQLLYSSVEN-IQRVAAGVLCELAQD-KEAADAIDAEGASAPLMELLHSR 637
Query: 169 NVAVCEQAVWALGNIAGD-GPEFRDNV---ITSNAIPH 202
N A L I+ D P++R V +T++ H
Sbjct: 638 NEGTATYAAAVLFRISEDKNPDYRKRVSVELTNSLFKH 675
>gi|47458043 armadillo repeat containing 8 isoform 3 [Homo sapiens]
Length = 385
Score = 39.3 bits (90), Expect = 0.009
Identities = 39/171 (22%), Positives = 76/171 (44%), Gaps = 8/171 (4%)
Query: 271 GSNKRIGQVVNTGVLPRLVVLM--TSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAGMLN 328
G+NK+ ++ G +PRL+ L+ +S + T +G++ GT+ + +D ++
Sbjct: 35 GNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIP 94
Query: 329 VLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYD--VLPPLVALLKNGEFKVQKE 386
L Q L + L + P ++LL D V+P L+ALL + +E
Sbjct: 95 ALLQGLLSPDLKFIEACLRCLRTIFTSPVTP-EELLYTDATVIPHLMALLSRSRY--TQE 151
Query: 387 AVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPDVKIVLIILDVISCI 437
+ + + Q I L + G ++ + +LLT+ K+ + L S +
Sbjct: 152 YICQIFSHCCKGPDHQTI-LFNHGAVQNIAHLLTSLSYKVRMQALKCFSVL 201
>gi|47458045 armadillo repeat containing 8 isoform 1 [Homo sapiens]
Length = 385
Score = 39.3 bits (90), Expect = 0.009
Identities = 39/171 (22%), Positives = 76/171 (44%), Gaps = 8/171 (4%)
Query: 271 GSNKRIGQVVNTGVLPRLVVLM--TSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAGMLN 328
G+NK+ ++ G +PRL+ L+ +S + T +G++ GT+ + +D ++
Sbjct: 35 GNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIP 94
Query: 329 VLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYD--VLPPLVALLKNGEFKVQKE 386
L Q L + L + P ++LL D V+P L+ALL + +E
Sbjct: 95 ALLQGLLSPDLKFIEACLRCLRTIFTSPVTP-EELLYTDATVIPHLMALLSRSRY--TQE 151
Query: 387 AVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPDVKIVLIILDVISCI 437
+ + + Q I L + G ++ + +LLT+ K+ + L S +
Sbjct: 152 YICQIFSHCCKGPDHQTI-LFNHGAVQNIAHLLTSLSYKVRMQALKCFSVL 201
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,157,430
Number of Sequences: 37866
Number of extensions: 736873
Number of successful extensions: 2492
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 33
Number of HSP's that attempted gapping in prelim test: 2195
Number of HSP's gapped (non-prelim): 116
length of query: 516
length of database: 18,247,518
effective HSP length: 107
effective length of query: 409
effective length of database: 14,195,856
effective search space: 5806105104
effective search space used: 5806105104
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.