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Search of human proteins with 224493972
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224493972 thioredoxin domain containing 5 isoform 3 [Homo
sapiens]
(324 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|42794771 thioredoxin domain containing 5 isoform 1 precursor ... 674 0.0
gi|224493972 thioredoxin domain containing 5 isoform 3 [Homo sap... 674 0.0
gi|5031973 protein disulfide isomerase A6 [Homo sapiens] 145 4e-35
gi|4758304 protein disulfide isomerase A4 [Homo sapiens] 144 8e-35
gi|5803121 protein disulfide isomerase A5 [Homo sapiens] 114 1e-25
gi|24308127 DnaJ (Hsp40) homolog, subfamily C, member 10 [Homo s... 107 2e-23
gi|21361657 protein disulfide-isomerase A3 precursor [Homo sapiens] 101 8e-22
gi|20070125 prolyl 4-hydroxylase, beta subunit precursor [Homo s... 86 3e-17
gi|94966757 protein disulfide isomerase A2 [Homo sapiens] 80 3e-15
gi|38505222 thioredoxin domain containing 10 [Homo sapiens] 74 2e-13
gi|52487191 thioredoxin domain containing 4 (endoplasmic reticul... 68 1e-11
gi|145580631 quiescin Q6 sulfhydryl oxidase 2 [Homo sapiens] 61 2e-09
gi|51873067 quiescin Q6 sulfhydryl oxidase 1 isoform b [Homo sap... 57 2e-08
gi|13325075 quiescin Q6 sulfhydryl oxidase 1 isoform a [Homo sap... 57 2e-08
gi|21361403 thioredoxin 2 precursor [Homo sapiens] 54 1e-07
gi|28372543 protein disulfide isomerase-like, testis expressed [... 54 2e-07
gi|151101292 thioredoxin domain containing 1 [Homo sapiens] 53 3e-07
gi|40254947 thioredoxin-related transmembrane protein 4 [Homo sa... 53 3e-07
gi|50592994 thioredoxin [Homo sapiens] 51 1e-06
gi|4759274 thioredoxin-like 1 [Homo sapiens] 48 1e-05
gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo sap... 47 3e-05
gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo sap... 47 3e-05
gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo sapi... 47 3e-05
gi|237648961 thioredoxin domain containing 16 isoform 2 [Homo sa... 46 4e-05
gi|237648959 thioredoxin domain containing 16 isoform 1 [Homo sa... 46 4e-05
gi|94421469 disulfide isomerase [Homo sapiens] 45 7e-05
gi|221136993 thioredoxin domain containing 14 isoform 2 [Homo sa... 43 3e-04
gi|7705726 thioredoxin domain containing 14 isoform 1 [Homo sapi... 43 3e-04
gi|95113651 glutaredoxin 3 [Homo sapiens] 42 7e-04
gi|54633317 thioredoxin domain containing 11 [Homo sapiens] 39 0.008
>gi|42794771 thioredoxin domain containing 5 isoform 1 precursor
[Homo sapiens]
Length = 432
Score = 674 bits (1740), Expect = 0.0
Identities = 324/324 (100%), Positives = 324/324 (100%)
Query: 1 MEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTL 60
MEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTL
Sbjct: 109 MEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTL 168
Query: 61 NEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWE 120
NEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWE
Sbjct: 169 NEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWE 228
Query: 121 QLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLRE 180
QLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLRE
Sbjct: 229 QLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLRE 288
Query: 181 YVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAP 240
YVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAP
Sbjct: 289 YVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAP 348
Query: 241 WCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKV 300
WCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKV
Sbjct: 349 WCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKV 408
Query: 301 SEHSGGRDLDSLHRFVLSQAKDEL 324
SEHSGGRDLDSLHRFVLSQAKDEL
Sbjct: 409 SEHSGGRDLDSLHRFVLSQAKDEL 432
Score = 204 bits (518), Expect = 1e-52
Identities = 106/235 (45%), Positives = 139/235 (59%), Gaps = 10/235 (4%)
Query: 87 SASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVK--IGKVDCTQHYE 144
+A F + HF+ FFAPWCGHC+ L PTW L E K + KVDCT H +
Sbjct: 67 TADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSD 126
Query: 145 LCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPV 204
+CS VRGYPTL F+ G++ +Y+G RD ++L ++ L E VTP
Sbjct: 127 VCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNE------EPVTPEPEVE 180
Query: 205 LAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLA 264
+ PE +G + L+ +NF+ +A+G FIKF+APWCGHCK LAPTWE+L+
Sbjct: 181 PPSAPELKQG-LYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLA-LGLEHSE 238
Query: 265 GVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFVLSQ 319
VKI +VDCT +CS VRGYPTLL FR GKKV ++ G RDL+SL +V SQ
Sbjct: 239 TVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQ 293
Score = 94.0 bits (232), Expect = 2e-19
Identities = 47/122 (38%), Positives = 66/122 (54%), Gaps = 1/122 (0%)
Query: 203 PVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKK-EFP 261
P E D + T + F I F+ F+APWCGHC+ L PTW +L K
Sbjct: 50 PAADGEDGQDPHSKHLYTADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSM 109
Query: 262 GLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFVLSQAK 321
A V +A+VDCTA ++CS VRGYPTL LF+ G++ ++ G RD +L ++L
Sbjct: 110 EDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLN 169
Query: 322 DE 323
+E
Sbjct: 170 EE 171
>gi|224493972 thioredoxin domain containing 5 isoform 3 [Homo
sapiens]
Length = 324
Score = 674 bits (1740), Expect = 0.0
Identities = 324/324 (100%), Positives = 324/324 (100%)
Query: 1 MEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTL 60
MEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTL
Sbjct: 1 MEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTL 60
Query: 61 NEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWE 120
NEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWE
Sbjct: 61 NEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWE 120
Query: 121 QLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLRE 180
QLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLRE
Sbjct: 121 QLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLRE 180
Query: 181 YVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAP 240
YVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAP
Sbjct: 181 YVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAP 240
Query: 241 WCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKV 300
WCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKV
Sbjct: 241 WCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKV 300
Query: 301 SEHSGGRDLDSLHRFVLSQAKDEL 324
SEHSGGRDLDSLHRFVLSQAKDEL
Sbjct: 301 SEHSGGRDLDSLHRFVLSQAKDEL 324
>gi|5031973 protein disulfide isomerase A6 [Homo sapiens]
Length = 440
Score = 145 bits (367), Expect = 4e-35
Identities = 81/237 (34%), Positives = 128/237 (54%), Gaps = 23/237 (9%)
Query: 85 ELSASNFELHVAQGDHF--IKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQH 142
EL+ SNF V Q D ++F+APWCGHC+ L P W++ A L+ + VK+G VD +H
Sbjct: 29 ELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALK--DVVKVGAVDADKH 86
Query: 143 YELCSGNQVRGYPTLLWFRDGK-KVDQYKGKRD--------LESLREYVESQLQRTETGA 193
+ L V+G+PT+ F K + + Y+G R L +LR+ V+ +L G
Sbjct: 87 HSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGY 146
Query: 194 TETVTPSEAPVLAAEPEADKGTVLALTENNFDDTI--AEGITFIKFYAPWCGHCKTLAPT 251
+ + K V+ LT+++FD + +E + ++FYAPWCGHCK L P
Sbjct: 147 SSGKQ-------GRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPE 199
Query: 252 WEELSKKEFPGLAG-VKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGR 307
W + + G VK+A VD T + + S+Y +RG+PT+ +F+ G+ ++ GGR
Sbjct: 200 WAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGR 256
Score = 79.7 bits (195), Expect = 3e-15
Identities = 53/181 (29%), Positives = 84/181 (46%), Gaps = 13/181 (7%)
Query: 6 VYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVK-YQGPRDFQTLENWMLQTLNE-- 62
V V VD H + GV+G+PT+K+F + + YQG R + + + L L +
Sbjct: 76 VKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLV 135
Query: 63 ------EPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDH--FIKFFAPWCGHCKA 114
+ S K+ + EL+ +F+ +V + ++F+APWCGHCK
Sbjct: 136 KDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKN 195
Query: 115 LAPTWEQLALGLEHSE--TVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGK 172
L P W A ++ VK+ VD T + L S +RG+PT+ F+ G+ Y G
Sbjct: 196 LEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGG 255
Query: 173 R 173
R
Sbjct: 256 R 256
Score = 46.6 bits (109), Expect = 3e-05
Identities = 22/64 (34%), Positives = 35/64 (54%)
Query: 5 KVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNEEP 64
KV +A VD T + + S G+RG+PT+K+F+ G+ V Y G R + + L ++
Sbjct: 214 KVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNA 273
Query: 65 VTPE 68
PE
Sbjct: 274 PPPE 277
>gi|4758304 protein disulfide isomerase A4 [Homo sapiens]
Length = 645
Score = 144 bits (364), Expect = 8e-35
Identities = 89/280 (31%), Positives = 145/280 (51%), Gaps = 24/280 (8%)
Query: 44 QGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDH-FI 102
+GP + + ++ EE + E E + + G+ L+ +NF+ VA D +
Sbjct: 25 EGPDEDSSNRENAIEDEEEEEEEDDDEEEDDLEVKEENGVLVLNDANFDNFVADKDTVLL 84
Query: 103 KFFAPWCGHCKALAPTWEQLALGLEHSET-VKIGKVDCTQHYELCSGNQVRGYPTLLWFR 161
+F+APWCGHCK AP +E++A L+ + + + K+D T L S V GYPT+ +
Sbjct: 85 EFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPTIKILK 144
Query: 162 DGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTE 221
G+ VD Y+G R E + V Q P PE L LT+
Sbjct: 145 KGQAVD-YEGSRTQEEIVAKVREVSQ---------------PDWTPPPEV----TLVLTK 184
Query: 222 NNFDDTIAEG-ITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNIC 280
NFD+ + + I ++FYAPWCGHCK LAP +E+ +K+ + +A+VD TAE ++
Sbjct: 185 ENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLA 244
Query: 281 SKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFVLSQA 320
++ V GYPTL +FR G+ +++G R+ + +++ Q+
Sbjct: 245 KRFDVSGYPTLKIFRKGRPY-DYNGPREKYGIVDYMIEQS 283
Score = 103 bits (258), Expect = 2e-22
Identities = 69/186 (37%), Positives = 94/186 (50%), Gaps = 16/186 (8%)
Query: 2 EDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLN 61
+D + VAK+D T+ S + S V GYPT+K+ K GQ AV Y+G R
Sbjct: 111 KDPPIPVAKIDATSASVLASRFDVSGYPTIKILKKGQ-AVDYEGSR------------TQ 157
Query: 62 EEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGD-HFIKFFAPWCGHCKALAPTWE 120
EE V EV P + L+ NF+ V D ++F+APWCGHCK LAP +E
Sbjct: 158 EEIVAKVREVSQPDWTPPPEVTLVLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYE 217
Query: 121 QLALGL-EHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLR 179
+ A L + S + + KVD T +L V GYPTL FR G+ D Y G R+ +
Sbjct: 218 KAAKELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKIFRKGRPYD-YNGPREKYGIV 276
Query: 180 EYVESQ 185
+Y+ Q
Sbjct: 277 DYMIEQ 282
Score = 87.8 bits (216), Expect = 1e-17
Identities = 61/173 (35%), Positives = 89/173 (51%), Gaps = 21/173 (12%)
Query: 163 GKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTEN 222
GKK + D ++LRE+V + + G + V S+ PV P+ +KG V +
Sbjct: 483 GKKFAMEPEEFDSDTLREFVTA----FKKGKLKPVIKSQ-PV----PKNNKGPVKVVVGK 533
Query: 223 NFDDTIAEGI--TFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNIC 280
FD + + I+FYAPWCGHCK L P + L+KK + G G+ IA++D TA
Sbjct: 534 TFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKK-YKGQKGLVIAKMDATANDVPS 592
Query: 281 SKYSVRGYPTLLLFRGGKK---VSEHSGGRDLDSLHRFV------LSQAKDEL 324
+Y V G+PT+ G K V G RDL+ L +F+ LS+ K+EL
Sbjct: 593 DRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIEEHATKLSRTKEEL 645
Score = 65.9 bits (159), Expect = 5e-11
Identities = 36/98 (36%), Positives = 55/98 (56%), Gaps = 6/98 (6%)
Query: 99 DHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLL 158
D I+F+APWCGHCK L P + LA + + + I K+D T + +V G+PT+
Sbjct: 545 DVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIY 604
Query: 159 WFRDGKKVDQYK---GKRDLESLREYVE---SQLQRTE 190
+ G K + K G RDLE L +++E ++L RT+
Sbjct: 605 FAPSGDKKNPVKFEGGDRDLEHLSKFIEEHATKLSRTK 642
>gi|5803121 protein disulfide isomerase A5 [Homo sapiens]
Length = 519
Score = 114 bits (285), Expect = 1e-25
Identities = 87/294 (29%), Positives = 139/294 (47%), Gaps = 36/294 (12%)
Query: 25 VRGYPTLKLFKPGQEAVKYQG-PRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQG- 82
VRG+PT+ F+ G+ +Y + + W+ + P P+P+V P P +G
Sbjct: 224 VRGFPTICYFEKGRFLFQYDNYGSTAEDIVEWL-----KNPQPPQPQV--PETPWADEGG 276
Query: 83 -LYELSASNFELHVAQGDH-FIKFFAPWCGHCKALAPTWEQLALGL--EHSETVKIGKVD 138
+Y L+ +F+ V + + F APWCGHCK + P +E+ A L E + + VD
Sbjct: 277 SVYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVD 336
Query: 139 CTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVT 198
T + L + +PTL +F++G+K Y L RT+ E +
Sbjct: 337 ATVNKALAERFHISEFPTLKYFKNGEK---------------YAVPVL-RTKKKFLEWMQ 380
Query: 199 PSEAPVLAAEP--EADKGTVLALTENNFDDTI-AEGITFIKFYAPWCGHCKTLAPTWEEL 255
EAP EP E + +VL L +NF +T+ + T + FYAPWC HCK + P +
Sbjct: 381 NPEAPP-PPEPTWEEQQTSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIPHF-TA 438
Query: 256 SKKEFPGLAGVKIAEVDCTAERN--ICSKYSVRGYPTLLLFRGGKKVSEHSGGR 307
+ F + A VDC ++N +C + +V+GYPT + GK ++ R
Sbjct: 439 TADAFKDDRKIACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYDSDR 492
Score = 91.3 bits (225), Expect = 1e-18
Identities = 58/202 (28%), Positives = 99/202 (49%), Gaps = 17/202 (8%)
Query: 102 IKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFR 161
I F+APWC CK + P +++ A L + V ++ + VRG+PT+ +F
Sbjct: 175 IMFYAPWCSMCKRMMPHFQKAATQLRGHAVLAGMNVYSSEFENIKEEYSVRGFPTICYFE 234
Query: 162 DGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADK-GTVLALT 220
G+ + QY + S E + L+ + P + P AD+ G+V LT
Sbjct: 235 KGRFLFQYD---NYGSTAEDIVEWLKNPQ---------PPQPQVPETPWADEGGSVYHLT 282
Query: 221 ENNFDDTIAE-GITFIKFYAPWCGHCKTLAPTWEELSKKEF--PGLAGVKIAEVDCTAER 277
+ +FD + E + F+APWCGHCK + P +E+ ++ +GV +A VD T +
Sbjct: 283 DEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGV-LAAVDATVNK 341
Query: 278 NICSKYSVRGYPTLLLFRGGKK 299
+ ++ + +PTL F+ G+K
Sbjct: 342 ALAERFHISEFPTLKYFKNGEK 363
Score = 80.1 bits (196), Expect = 2e-15
Identities = 54/187 (28%), Positives = 82/187 (43%), Gaps = 15/187 (8%)
Query: 3 DAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGP--RDFQTLENWMLQTL 60
D+ +A VD T + + + +PTLK FK G+ KY P R + WM
Sbjct: 327 DSSGVLAAVDATVNKALAERFHISEFPTLKYFKNGE---KYAVPVLRTKKKFLEWMQNP- 382
Query: 61 NEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDH-FIKFFAPWCGHCKALAPTW 119
E P PEP E E + + L NF + + H + F+APWC HCK + P +
Sbjct: 383 -EAPPPPEPTWE-----EQQTSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIPHF 436
Query: 120 EQLALGLEHSETVKIGKVDCTQ--HYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLES 177
A + + VDC + + +LC V+GYPT ++ GK ++Y R
Sbjct: 437 TATADAFKDDRKIACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYDSDRTELG 496
Query: 178 LREYVES 184
Y+ +
Sbjct: 497 FTNYIRA 503
Score = 38.5 bits (88), Expect = 0.008
Identities = 18/48 (37%), Positives = 26/48 (54%), Gaps = 2/48 (4%)
Query: 2 EDAKVYVAKVDCTA--HSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPR 47
+D K+ A VDC + D+C + V+GYPT + G+ A KY R
Sbjct: 445 DDRKIACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYDSDR 492
>gi|24308127 DnaJ (Hsp40) homolog, subfamily C, member 10 [Homo
sapiens]
Length = 793
Score = 107 bits (266), Expect = 2e-23
Identities = 76/296 (25%), Positives = 123/296 (41%), Gaps = 64/296 (21%)
Query: 11 VDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPE 70
+DCT H +C+ ++ YPT +F +Y+G + + ++ +N V+
Sbjct: 506 LDCTVHEGLCNMYNIQAYPTTVVFNQSN-IHEYEGHHSAEQILEFIEDLMNPSVVS---- 560
Query: 71 VEPPSAPELKQGLYELSASNFELHVAQGDH----FIKFFAPWCGHCKALAPTWEQLALGL 126
L+ + F V Q H + F++PWC C+ L P W+++A L
Sbjct: 561 ---------------LTPTTFNELVTQRKHNEVWMVDFYSPWCHPCQVLMPEWKRMARTL 605
Query: 127 EHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWF----RDGKKVDQYKG-KRDLESLREY 181
+ + +G +DC Q++ C+ V+ YP + +F Y G RD SLR +
Sbjct: 606 --TGLINVGSIDCQQYHSFCAQENVQRYPEIRFFPPKSNKAYHYHSYNGWNRDAYSLRIW 663
Query: 182 VESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITF--IKFYA 239
L + T LT F + + +G I FYA
Sbjct: 664 GLGFLPQVSTD--------------------------LTPQTFSEKVLQGKNHWVIDFYA 697
Query: 240 PWCGHCKTLAPTWEELSKKEFPGLAG-VKIAEVDCTAERNICSKYSVRGYPTLLLF 294
PWCG C+ AP +E L++ + G VK +VDC A C K +R YPT+ +
Sbjct: 698 PWCGPCQNFAPEFELLARM----IKGKVKAGKVDCQAYAQTCQKAGIRAYPTVKFY 749
Score = 101 bits (251), Expect = 1e-21
Identities = 76/313 (24%), Positives = 139/313 (44%), Gaps = 63/313 (20%)
Query: 1 MEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQ---GPRDFQTLENWML 57
+++ + V + DC++ D+CS V P+L +FK GQ +Y+ G + + +
Sbjct: 391 LKNDHIQVGRFDCSSAPDICSNLYVF-QPSLAVFK-GQGTKEYEIHHGKKILYDILAFAK 448
Query: 58 QTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAP 117
+++N T P+ P + E + FFAPWC C+AL P
Sbjct: 449 ESVNSHVTTLGPQNFPANDKE--------------------PWLVDFFAPWCPPCRALLP 488
Query: 118 TWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLES 177
+ A L + + +K G +DCT H LC+ ++ YPT + F + +Y+G E
Sbjct: 489 ELRR-ASNLLYGQ-LKFGTLDCTVHEGLCNMYNIQAYPTTVVFNQSN-IHEYEGHHSAEQ 545
Query: 178 LREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEG----IT 233
+ E++E + + PS V++LT F++ + + +
Sbjct: 546 ILEFIE-----------DLMNPS---------------VVSLTPTTFNELVTQRKHNEVW 579
Query: 234 FIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLL 293
+ FY+PWC C+ L P W+ ++ + GL + + +DC + C++ +V+ YP +
Sbjct: 580 MVDFYSPWCHPCQVLMPEWKRMA-RTLTGL--INVGSIDCQQYHSFCAQENVQRYPEIRF 636
Query: 294 F--RGGKKVSEHS 304
F + K HS
Sbjct: 637 FPPKSNKAYHYHS 649
Score = 75.5 bits (184), Expect = 6e-14
Identities = 38/111 (34%), Positives = 58/111 (52%), Gaps = 4/111 (3%)
Query: 212 DKGTVLALTENNFDDTIAEG-ITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAE 270
D ++ L FD + G + F+ FY+P C HC LAPTW + + KE GL ++I
Sbjct: 127 DDPEIITLERREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWRDFA-KEVDGL--LRIGA 183
Query: 271 VDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFVLSQAK 321
V+C +R +C V YP+L +FR G ++ G R +SL F + +
Sbjct: 184 VNCGDDRMLCRMKGVNSYPSLFIFRSGMAPVKYHGDRSKESLVSFAMQHVR 234
Score = 72.4 bits (176), Expect = 5e-13
Identities = 49/162 (30%), Positives = 72/162 (44%), Gaps = 28/162 (17%)
Query: 6 VYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAV----KYQG-PRDFQTLENWMLQTL 60
+ V +DC + C+ + V+ YP ++ F P Y G RD +L W L L
Sbjct: 609 INVGSIDCQQYHSFCAQENVQRYPEIRFFPPKSNKAYHYHSYNGWNRDAYSLRIWGLGFL 668
Query: 61 NEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHF--IKFFAPWCGHCKALAPT 118
P+V P+ F V QG + I F+APWCG C+ AP
Sbjct: 669 --------PQVSTDLTPQ-----------TFSEKVLQGKNHWVIDFYAPWCGPCQNFAPE 709
Query: 119 WEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWF 160
+E LA ++ VK GKVDC + + C +R YPT+ ++
Sbjct: 710 FELLARMIKGK--VKAGKVDCQAYAQTCQKAGIRAYPTVKFY 749
Score = 68.6 bits (166), Expect = 7e-12
Identities = 58/201 (28%), Positives = 81/201 (40%), Gaps = 29/201 (14%)
Query: 86 LSASNFELHVAQGD-HFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYE 144
L F+ V G+ F+ F++P C HC LAPTW A E ++IG V+C
Sbjct: 134 LERREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWRDFAK--EVDGLLRIGAVNCGDDRM 191
Query: 145 LCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPV 204
LC V YP+L FR G +Y G R ESL V +Q + TE T +
Sbjct: 192 LCRMKGVNSYPSLFIFRSGMAPVKYHGDRSKESL---VSFAMQHVRSTVTELWTGNFV-- 246
Query: 205 LAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLA 264
N+ A GI ++ + G C T + T LS GL
Sbjct: 247 -----------------NSIQTAFAAGIGWLITFCSKGGDCLT-SQTRLRLSGM-LDGL- 286
Query: 265 GVKIAEVDCTAERNICSKYSV 285
V + +DC + N+C +
Sbjct: 287 -VNVGWMDCATQDNLCKSLDI 306
Score = 41.2 bits (95), Expect = 0.001
Identities = 34/144 (23%), Positives = 59/144 (40%), Gaps = 18/144 (12%)
Query: 3 DAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNE 62
D + + V+C +C +GV YP+L +F+ G VKY G R ++L ++ +Q +
Sbjct: 176 DGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAPVKYHGDRSKESLVSFAMQHVRS 235
Query: 63 EPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQL 122
+ EL G + ++ + A G ++ F G C + +L
Sbjct: 236 ------------TVTELWTGNF---VNSIQTAFAAGIGWLITFCSKGGDC---LTSQTRL 277
Query: 123 ALGLEHSETVKIGKVDCTQHYELC 146
L V +G +DC LC
Sbjct: 278 RLSGMLDGLVNVGWMDCATQDNLC 301
Score = 38.1 bits (87), Expect = 0.011
Identities = 15/34 (44%), Positives = 20/34 (58%)
Query: 1 MEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLF 34
M KV KVDC A++ C G+R YPT+K +
Sbjct: 716 MIKGKVKAGKVDCQAYAQTCQKAGIRAYPTVKFY 749
>gi|21361657 protein disulfide-isomerase A3 precursor [Homo sapiens]
Length = 505
Score = 101 bits (252), Expect = 8e-22
Identities = 55/127 (43%), Positives = 76/127 (59%), Gaps = 9/127 (7%)
Query: 199 PSEAPVLAAEPEADKGTVLALTENNFD----DTIAEGITFIKFYAPWCGHCKTLAPTWEE 254
P A +LAA A VL LT++NF+ DT + G+ ++F+APWCGHCK LAP +E
Sbjct: 10 PGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEA 69
Query: 255 LSKKEFPGLAG-VKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLH 313
+ + L G V +A+VDCTA N C+KY V GYPTL +FR G++ + G R D +
Sbjct: 70 AATR----LKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIV 125
Query: 314 RFVLSQA 320
+ QA
Sbjct: 126 SHLKKQA 132
Score = 83.2 bits (204), Expect = 3e-16
Identities = 43/105 (40%), Positives = 60/105 (57%), Gaps = 6/105 (5%)
Query: 85 ELSASNFELHVAQ----GDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCT 140
EL+ NFE ++ G ++FFAPWCGHCK LAP +E A L+ V + KVDCT
Sbjct: 29 ELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKG--IVPLAKVDCT 86
Query: 141 QHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQ 185
+ C+ V GYPTL FRDG++ Y G R + + +++ Q
Sbjct: 87 ANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQ 131
Score = 78.2 bits (191), Expect = 9e-15
Identities = 53/164 (32%), Positives = 86/164 (52%), Gaps = 27/164 (16%)
Query: 161 RDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALT 220
RDGK ++++ L++Y + L+R SE P+ PE++ G V +
Sbjct: 344 RDGKALERF--------LQDYFDGNLKR--------YLKSE-PI----PESNDGPVKVVV 382
Query: 221 ENNFDDTI--AEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERN 278
NFD+ + I+FYAPWCGHCK L P ++EL +K + IA++D TA +
Sbjct: 383 AENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEK-LSKDPNIVIAKMDATA-ND 440
Query: 279 ICSKYSVRGYPTLLLFRGGKKVS--EHSGGRDLDSLHRFVLSQA 320
+ S Y VRG+PT+ KK++ ++ GGR+L ++ +A
Sbjct: 441 VPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQREA 484
Score = 65.9 bits (159), Expect = 5e-11
Identities = 35/102 (34%), Positives = 60/102 (58%), Gaps = 5/102 (4%)
Query: 88 ASNFE--LHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYEL 145
A NF+ ++ D I+F+APWCGHCK L P +++L L + I K+D T + ++
Sbjct: 383 AENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATAN-DV 441
Query: 146 CSGNQVRGYPTLLWFRDGKKVD--QYKGKRDLESLREYVESQ 185
S +VRG+PT+ + KK++ +Y+G R+L Y++ +
Sbjct: 442 PSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQRE 483
Score = 58.5 bits (140), Expect = 8e-09
Identities = 25/42 (59%), Positives = 33/42 (78%)
Query: 6 VYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPR 47
V +AKVDCTA+++ C+ GV GYPTLK+F+ G+EA Y GPR
Sbjct: 78 VPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPR 119
>gi|20070125 prolyl 4-hydroxylase, beta subunit precursor [Homo
sapiens]
Length = 508
Score = 86.3 bits (212), Expect = 3e-17
Identities = 42/114 (36%), Positives = 69/114 (60%), Gaps = 3/114 (2%)
Query: 202 APVLAAEPEADKGTVLALTENNFDDTIA-EGITFIKFYAPWCGHCKTLAPTWEELSKKEF 260
A ++ A+ ++ VL L ++NF + +A ++FYAPWCGHCK LAP + + + K
Sbjct: 12 AALVRADAPEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLK 71
Query: 261 PGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVS--EHSGGRDLDSL 312
+ +++A+VD T E ++ +Y VRGYPT+ FR G S E++ GR+ D +
Sbjct: 72 AEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDI 125
Score = 76.3 bits (186), Expect = 4e-14
Identities = 51/149 (34%), Positives = 78/149 (52%), Gaps = 14/149 (9%)
Query: 76 APELKQGLYELSASNFELHVAQGDHF-IKFFAPWCGHCKALAPTWEQLA--LGLEHSETV 132
APE + + L SNF +A + ++F+APWCGHCKALAP + + A L E SE +
Sbjct: 19 APEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSE-I 77
Query: 133 KIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVD--QYKGKRDLESLREYVESQLQRTE 190
++ KVD T+ +L VRGYPT+ +FR+G +Y R+ + + +++ +
Sbjct: 78 RLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVNWLKKR----- 132
Query: 191 TGATETVTPSEAPVLAAEPEADKGTVLAL 219
TG T P A AAE + V +
Sbjct: 133 TGPAATTLPDGA---AAESLVESSEVAVI 158
Score = 72.0 bits (175), Expect = 7e-13
Identities = 42/115 (36%), Positives = 61/115 (53%), Gaps = 7/115 (6%)
Query: 212 DKGTVLALTENNFDDTIAEGI--TFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIA 269
DK V L NF+D + F++FYAPWCGHCK LAP W++L + + + IA
Sbjct: 365 DKQPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLG-ETYKDHENIVIA 423
Query: 270 EVDCTAERNICSKYSVRGYPTLLLF--RGGKKVSEHSGGRDLDSLHRFVLSQAKD 322
++D TA N V +PTL F + V +++G R LD +F+ S +D
Sbjct: 424 KMDSTA--NEVEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKKFLESGGQD 476
Score = 68.2 bits (165), Expect = 1e-11
Identities = 40/110 (36%), Positives = 61/110 (55%), Gaps = 8/110 (7%)
Query: 80 KQGLYELSASNFELHVAQGDH---FIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGK 136
KQ + L NFE VA + F++F+APWCGHCK LAP W++L + E + I K
Sbjct: 366 KQPVKVLVGKNFE-DVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENIVIAK 424
Query: 137 VDCTQHYELCSGNQVRGYPTLLWF--RDGKKVDQYKGKRDLESLREYVES 184
+D T + +V +PTL +F + V Y G+R L+ ++++ES
Sbjct: 425 MDSTANE--VEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKKFLES 472
Score = 48.9 bits (115), Expect = 6e-06
Identities = 23/57 (40%), Positives = 34/57 (59%), Gaps = 2/57 (3%)
Query: 2 EDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEA--VKYQGPRDFQTLENWM 56
E +++ +AKVD T SD+ GVRGYPT+K F+ G A +Y R+ + NW+
Sbjct: 73 EGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVNWL 129
>gi|94966757 protein disulfide isomerase A2 [Homo sapiens]
Length = 525
Score = 79.7 bits (195), Expect = 3e-15
Identities = 44/112 (39%), Positives = 64/112 (57%), Gaps = 7/112 (6%)
Query: 209 PEADKGTVLALTENNFDDTIAEGI--TFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGV 266
P+ D+ V L NF+ + F+KFYAPWC HCK +AP WE L++K + +
Sbjct: 383 PDWDQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEK-YQDHEDI 441
Query: 267 KIAEVDCTAERNICSKYSVRGYPTLLLFRG--GKKVSEHSGGRDLDSLHRFV 316
IAE+D TA N ++V G+PTL F G+KV E+ RDL++ +F+
Sbjct: 442 IIAELDATA--NELDAFAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKFL 491
Score = 75.9 bits (185), Expect = 5e-14
Identities = 46/123 (37%), Positives = 66/123 (53%), Gaps = 11/123 (8%)
Query: 101 FIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWF 160
F+KF+APWC HCK +AP WE LA + E + I ++D T + EL V G+PTL +F
Sbjct: 410 FVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDATAN-EL-DAFAVHGFPTLKYF 467
Query: 161 --RDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLA 218
G+KV +YK RDLE+ +++++ G T P E P A PE + +
Sbjct: 468 PAGPGRKVIEYKSTRDLETFSKFLDN------GGVLPTEEPPEEPA-APFPEPPANSTMG 520
Query: 219 LTE 221
E
Sbjct: 521 SKE 523
Score = 72.4 bits (176), Expect = 5e-13
Identities = 57/182 (31%), Positives = 86/182 (47%), Gaps = 18/182 (9%)
Query: 62 EEPVTPEPEVEPPSAPELKQ-GLYELSASNFELHVAQGDH---FIKFFAPWCGHCKALAP 117
+E P EPP K+ G+ LS L +A +H ++F+APWCGHC+ALAP
Sbjct: 22 QEQGARSPSEEPPEEEIPKEDGILVLSRHT--LGLALREHPALLVEFYAPWCGHCQALAP 79
Query: 118 TWEQLALGL-EHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKV--DQYKGKRD 174
+ + A L S V + KVD EL V YPTL +FR+G + ++Y G RD
Sbjct: 80 EYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRD 139
Query: 175 LESLREYVE-----SQLQRTETGATETVTPSEAPVLAA----EPEADKGTVLALTENNFD 225
E + E++ S ++ + A + + V+ + D T LAL ++ D
Sbjct: 140 AEGIAEWLRRRVGPSAMRLEDEAAAQALIGGRDLVVIGFFQDLQDEDVATFLALAQDALD 199
Query: 226 DT 227
T
Sbjct: 200 MT 201
Score = 69.3 bits (168), Expect = 4e-12
Identities = 39/118 (33%), Positives = 62/118 (52%), Gaps = 5/118 (4%)
Query: 198 TPSEAPVLAAEPEADKGTVLALTENNFDDTIAEG-ITFIKFYAPWCGHCKTLAPTWEELS 256
+PSE P P+ D +L L+ + + E ++FYAPWCGHC+ LAP + + +
Sbjct: 28 SPSEEPPEEEIPKEDG--ILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKAA 85
Query: 257 KKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKV--SEHSGGRDLDSL 312
V +A+VD A+R + ++ V YPTL FR G + E++G RD + +
Sbjct: 86 AVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAEGI 143
Score = 43.1 bits (100), Expect = 3e-04
Identities = 24/71 (33%), Positives = 35/71 (49%), Gaps = 2/71 (2%)
Query: 2 EDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEA--VKYQGPRDFQTLENWMLQT 59
E V +AKVD A ++ GV YPTLK F+ G +Y GPRD + + W+ +
Sbjct: 91 ESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAEGIAEWLRRR 150
Query: 60 LNEEPVTPEPE 70
+ + E E
Sbjct: 151 VGPSAMRLEDE 161
Score = 42.4 bits (98), Expect = 6e-04
Identities = 26/79 (32%), Positives = 42/79 (53%), Gaps = 13/79 (16%)
Query: 6 VYVAKVDCTAHSDVCSAQGVRGYPTLKLFK--PGQEAVKYQGPRDFQTLENWM------- 56
+ +A++D TA+ A V G+PTLK F PG++ ++Y+ RD +T ++
Sbjct: 441 IIIAELDATANE--LDAFAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKFLDNGGVLP 498
Query: 57 LQTLNEEPVTPEPEVEPPS 75
+ EEP P P EPP+
Sbjct: 499 TEEPPEEPAAPFP--EPPA 515
>gi|38505222 thioredoxin domain containing 10 [Homo sapiens]
Length = 454
Score = 73.6 bits (179), Expect = 2e-13
Identities = 41/114 (35%), Positives = 62/114 (54%), Gaps = 2/114 (1%)
Query: 202 APVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFP 261
A V+ + KG V L E+ F + + I + FYAPWCGHCK L P W E+ +
Sbjct: 14 ATVVVLDMVVCKGFVEDLDES-FKENRNDDIWLVDFYAPWCGHCKKLEPIWNEVGLEMKS 72
Query: 262 GLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRF 315
+ VK+ ++D T+ +I S++ VRGYPT+ L +G + + G R D + F
Sbjct: 73 IGSPVKVGKMDATSYSSIASEFGVRGYPTIKLLKGDLAYN-YRGPRTKDDIIEF 125
Score = 67.8 bits (164), Expect = 1e-11
Identities = 31/81 (38%), Positives = 47/81 (58%), Gaps = 2/81 (2%)
Query: 102 IKFFAPWCGHCKALAPTWEQLALGLEH-SETVKIGKVDCTQHYELCSGNQVRGYPTLLWF 160
+ F+APWCGHCK L P W ++ L ++ VK+GK+D T + + S VRGYPT+
Sbjct: 46 VDFYAPWCGHCKKLEPIWNEVGLEMKSIGSPVKVGKMDATSYSSIASEFGVRGYPTIKLL 105
Query: 161 RDGKKVDQYKGKRDLESLREY 181
+ G Y+G R + + E+
Sbjct: 106 K-GDLAYNYRGPRTKDDIIEF 125
Score = 46.6 bits (109), Expect = 3e-05
Identities = 23/42 (54%), Positives = 29/42 (69%), Gaps = 1/42 (2%)
Query: 6 VYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPR 47
V V K+D T++S + S GVRGYPT+KL K G A Y+GPR
Sbjct: 77 VKVGKMDATSYSSIASEFGVRGYPTIKLLK-GDLAYNYRGPR 117
>gi|52487191 thioredoxin domain containing 4 (endoplasmic reticulum)
[Homo sapiens]
Length = 406
Score = 67.8 bits (164), Expect = 1e-11
Identities = 38/114 (33%), Positives = 57/114 (50%), Gaps = 5/114 (4%)
Query: 216 VLALTENNFDDTIAEG-ITFIKFYAPWCGHCKTLAPTWEELS---KKEFPGLAGVKIAEV 271
+ +L N D+ + + + FYA WC + L P +EE S K+EFP V A V
Sbjct: 31 ITSLDTENIDEILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARV 90
Query: 272 DCTAERNICSKYSVRGYPTLLLFRGGKKVS-EHSGGRDLDSLHRFVLSQAKDEL 324
DC +I +Y + YPTL LFR G + E+ G R + +L ++ Q D +
Sbjct: 91 DCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQKSDPI 144
Score = 55.1 bits (131), Expect = 8e-08
Identities = 26/89 (29%), Positives = 50/89 (56%), Gaps = 5/89 (5%)
Query: 102 IKFFAPWCGHCKALAPTWEQLALGLE----HSETVKIGKVDCTQHYELCSGNQVRGYPTL 157
+ F+A WC + L P +E+ + ++ + V +VDC QH ++ ++ YPTL
Sbjct: 51 VNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTL 110
Query: 158 LWFRDGKKVD-QYKGKRDLESLREYVESQ 185
FR+G + +Y+G+R +++L +Y+ Q
Sbjct: 111 KLFRNGMMMKREYRGQRSVKALADYIRQQ 139
Score = 43.1 bits (100), Expect = 3e-04
Identities = 21/55 (38%), Positives = 32/55 (58%), Gaps = 1/55 (1%)
Query: 5 KVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVK-YQGPRDFQTLENWMLQ 58
+V A+VDC HSD+ + YPTLKLF+ G + Y+G R + L +++ Q
Sbjct: 84 QVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQ 138
>gi|145580631 quiescin Q6 sulfhydryl oxidase 2 [Homo sapiens]
Length = 698
Score = 60.8 bits (146), Expect = 2e-09
Identities = 29/90 (32%), Positives = 44/90 (48%), Gaps = 8/90 (8%)
Query: 212 DKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEV 271
D G+V T N+ ++FY+ WCGHC APTW L+ + +++A +
Sbjct: 67 DSGSVRGATANS------SAAWLVQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAAL 120
Query: 272 DCTAERN--ICSKYSVRGYPTLLLFRGGKK 299
DC E+N +C Y + YPT F+ K
Sbjct: 121 DCMEEKNQAVCHDYDIHFYPTFRYFKAFTK 150
Score = 56.2 bits (134), Expect = 4e-08
Identities = 35/136 (25%), Positives = 66/136 (48%), Gaps = 15/136 (11%)
Query: 102 IKFFAPWCGHCKALAPTWEQLALGL-EHSETVKIGKVDCTQ--HYELCSGNQVRGYPTLL 158
++F++ WCGHC APTW LA + + + +++ +DC + + +C + YPT
Sbjct: 84 VQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAALDCMEEKNQAVCHDYDIHFYPTFR 143
Query: 159 WFRDGKKV----DQYKG-KRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADK 213
+F+ K + +KG R+L ++R+ + LQ G+ P P+ ++
Sbjct: 144 YFKAFTKEFTTGENFKGPDRELRTVRQTMIDFLQNHTEGSRPPACPRLDPIQPSD----- 198
Query: 214 GTVLALTENNFDDTIA 229
VL+L +N +A
Sbjct: 199 --VLSLLDNRGSHYVA 212
>gi|51873067 quiescin Q6 sulfhydryl oxidase 1 isoform b [Homo
sapiens]
Length = 604
Score = 57.4 bits (137), Expect = 2e-08
Identities = 23/67 (34%), Positives = 39/67 (58%), Gaps = 2/67 (2%)
Query: 235 IKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERN--ICSKYSVRGYPTLL 292
++F+A WCGHC APTW+ L++ + +A +DC E N +C +++ G+PT+
Sbjct: 63 VEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVR 122
Query: 293 LFRGGKK 299
F+ K
Sbjct: 123 FFKAFTK 129
Score = 53.1 bits (126), Expect = 3e-07
Identities = 53/204 (25%), Positives = 91/204 (44%), Gaps = 30/204 (14%)
Query: 102 IKFFAPWCGHCKALAPTWEQLALGLE-HSETVKIGKVDCTQ--HYELCSGNQVRGYPTLL 158
++FFA WCGHC A APTW+ LA ++ + + +DC + + +C + G+PT+
Sbjct: 63 VEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVR 122
Query: 159 WF----RDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKG 214
+F ++G D+++LRE + L+ +T P+ P+ A+ E G
Sbjct: 123 FFKAFTKNGSGAVFPVAGADVQTLRERLIDALESHH----DTWPPACPPLEPAKLEEIDG 178
Query: 215 TVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCT 274
E +G +++ G L +LS+ + GV + V
Sbjct: 179 FFARNNEEYLALIFEKGGSYL-------GREVAL-----DLSQHK-----GVAVRRV-LN 220
Query: 275 AERNICSKYSVRGYPT-LLLFRGG 297
E N+ K+ V +P+ LLFR G
Sbjct: 221 TEANVVRKFGVTDFPSCYLLFRNG 244
Score = 36.2 bits (82), Expect = 0.041
Identities = 54/216 (25%), Positives = 78/216 (36%), Gaps = 37/216 (17%)
Query: 6 VYVAKVDCT--AHSDVCSAQGVRGYPTLKLFKP----GQEAVKYQGPRDFQTLENWMLQT 59
+Y+A +DC +S VC + G+PT++ FK G AV D QTL ++
Sbjct: 94 LYLAALDCAEETNSAVCRDFNIPGFPTVRFFKAFTKNGSGAVFPVAGADVQTLRERLIDA 153
Query: 60 LNEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVA-----QGDHFIKFFAPWCGHCKA 114
L T P PP P + + A N E ++A G + + A K
Sbjct: 154 LESHHDTWPPAC-PPLEPAKLEEIDGFFARNNEEYLALIFEKGGSYLGREVALDLSQHKG 212
Query: 115 LAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRD 174
+A + L E + K G D Y L V P L+
Sbjct: 213 VA---VRRVLNTEANVVRKFGVTDFPSCYLLFRNGSVSRVPVLM---------------- 253
Query: 175 LESLREYVESQLQR----TETGATETVTPSEAPVLA 206
R + + LQR T A TV P+ A +A
Sbjct: 254 --ESRSFYTAYLQRLSGLTREAAQTTVAPTTANKIA 287
>gi|13325075 quiescin Q6 sulfhydryl oxidase 1 isoform a [Homo
sapiens]
Length = 747
Score = 57.4 bits (137), Expect = 2e-08
Identities = 23/67 (34%), Positives = 39/67 (58%), Gaps = 2/67 (2%)
Query: 235 IKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERN--ICSKYSVRGYPTLL 292
++F+A WCGHC APTW+ L++ + +A +DC E N +C +++ G+PT+
Sbjct: 63 VEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVR 122
Query: 293 LFRGGKK 299
F+ K
Sbjct: 123 FFKAFTK 129
Score = 53.1 bits (126), Expect = 3e-07
Identities = 53/204 (25%), Positives = 91/204 (44%), Gaps = 30/204 (14%)
Query: 102 IKFFAPWCGHCKALAPTWEQLALGLE-HSETVKIGKVDCTQ--HYELCSGNQVRGYPTLL 158
++FFA WCGHC A APTW+ LA ++ + + +DC + + +C + G+PT+
Sbjct: 63 VEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVR 122
Query: 159 WF----RDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKG 214
+F ++G D+++LRE + L+ +T P+ P+ A+ E G
Sbjct: 123 FFKAFTKNGSGAVFPVAGADVQTLRERLIDALESHH----DTWPPACPPLEPAKLEEIDG 178
Query: 215 TVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCT 274
E +G +++ G L +LS+ + GV + V
Sbjct: 179 FFARNNEEYLALIFEKGGSYL-------GREVAL-----DLSQHK-----GVAVRRV-LN 220
Query: 275 AERNICSKYSVRGYPT-LLLFRGG 297
E N+ K+ V +P+ LLFR G
Sbjct: 221 TEANVVRKFGVTDFPSCYLLFRNG 244
Score = 36.2 bits (82), Expect = 0.041
Identities = 54/216 (25%), Positives = 78/216 (36%), Gaps = 37/216 (17%)
Query: 6 VYVAKVDCT--AHSDVCSAQGVRGYPTLKLFKP----GQEAVKYQGPRDFQTLENWMLQT 59
+Y+A +DC +S VC + G+PT++ FK G AV D QTL ++
Sbjct: 94 LYLAALDCAEETNSAVCRDFNIPGFPTVRFFKAFTKNGSGAVFPVAGADVQTLRERLIDA 153
Query: 60 LNEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVA-----QGDHFIKFFAPWCGHCKA 114
L T P PP P + + A N E ++A G + + A K
Sbjct: 154 LESHHDTWPPAC-PPLEPAKLEEIDGFFARNNEEYLALIFEKGGSYLGREVALDLSQHKG 212
Query: 115 LAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRD 174
+A + L E + K G D Y L V P L+
Sbjct: 213 VA---VRRVLNTEANVVRKFGVTDFPSCYLLFRNGSVSRVPVLM---------------- 253
Query: 175 LESLREYVESQLQR----TETGATETVTPSEAPVLA 206
R + + LQR T A TV P+ A +A
Sbjct: 254 --ESRSFYTAYLQRLSGLTREAAQTTVAPTTANKIA 287
>gi|21361403 thioredoxin 2 precursor [Homo sapiens]
Length = 166
Score = 54.3 bits (129), Expect = 1e-07
Identities = 39/129 (30%), Positives = 59/129 (45%), Gaps = 18/129 (13%)
Query: 196 TVTPSEAPVLAAEPEADKGTVLALTENN------FDDTIAEGIT--FIKFYAPWCGHCKT 247
TVTP+ A + T ++LT N F D + T + F+A WCG CK
Sbjct: 43 TVTPNPARTIYT-------TRISLTTFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKI 95
Query: 248 LAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGR 307
L P E++ K+ V +A+VD ++ +Y V PT+L + G V + G +
Sbjct: 96 LGPRLEKMVAKQH---GKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIK 152
Query: 308 DLDSLHRFV 316
D D L F+
Sbjct: 153 DEDQLEAFL 161
Score = 53.5 bits (127), Expect = 2e-07
Identities = 27/82 (32%), Positives = 46/82 (56%), Gaps = 2/82 (2%)
Query: 102 IKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFR 161
+ F A WCG CK L P E++ + +H + V + KVD H +L +V PT+L +
Sbjct: 83 VDFHAQWCGPCKILGPRLEKM-VAKQHGKVV-MAKVDIDDHTDLAIEYEVSAVPTVLAMK 140
Query: 162 DGKKVDQYKGKRDLESLREYVE 183
+G VD++ G +D + L +++
Sbjct: 141 NGDVVDKFVGIKDEDQLEAFLK 162
Score = 33.1 bits (74), Expect = 0.34
Identities = 18/55 (32%), Positives = 27/55 (49%)
Query: 2 EDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWM 56
+ KV +AKVD H+D+ V PT+ K G K+ G +D LE ++
Sbjct: 107 QHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIKDEDQLEAFL 161
>gi|28372543 protein disulfide isomerase-like, testis expressed
[Homo sapiens]
Length = 584
Score = 53.5 bits (127), Expect = 2e-07
Identities = 49/196 (25%), Positives = 93/196 (47%), Gaps = 14/196 (7%)
Query: 29 PTLKLFKPGQEAVKYQGPRD---FQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLY- 84
P++++ +A +Y+ P D +++L+ + L++ + E P + QGL
Sbjct: 334 PSVQILNLSSDA-RYKMPSDDITYESLKKFGRSFLSKNATKHQSSEEIPKYWD--QGLVK 390
Query: 85 ELSASNFELHV--AQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQH 142
+L NF + V + D F+ F+APW CK L P E+L ++ T+ I K+D T +
Sbjct: 391 QLVGKNFNVVVFDKEKDVFVMFYAPWSKKCKMLFPLLEELGRKYQNHSTIIIAKIDVTAN 450
Query: 143 -YELCSGNQVRGYPTLLWFRDG-KKVDQYKGKRDLESLREYVESQLQRTETGATETVTPS 200
+L + YP F G ++ YKG+ L+ +++ES ++ E ++
Sbjct: 451 DIQLM---YLDRYPFFRLFPSGSQQAVLYKGEHTLKGFSDFLESHIKTKIEDEDELLSVE 507
Query: 201 EAPVLAAEPEADKGTV 216
+ V+ E A++ V
Sbjct: 508 QNEVIEEEVLAEEKEV 523
Score = 50.8 bits (120), Expect = 2e-06
Identities = 49/155 (31%), Positives = 73/155 (47%), Gaps = 18/155 (11%)
Query: 176 ESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTI--AEGIT 233
ESL+++ S L + AT+ + E P D+G V L NF+ + E
Sbjct: 357 ESLKKFGRSFLSKN---ATKHQSSEEIPKYW-----DQGLVKQLVGKNFNVVVFDKEKDV 408
Query: 234 FIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLL 293
F+ FYAPW CK L P EEL +K + + + IA++D TA +I Y R YP L
Sbjct: 409 FVMFYAPWSKKCKMLFPLLEELGRK-YQNHSTIIIAKIDVTA-NDIQLMYLDR-YPFFRL 465
Query: 294 FRGGKKVS-----EHSGGRDLDSLHRFVLSQAKDE 323
F G + + EH+ D L + ++ +DE
Sbjct: 466 FPSGSQQAVLYKGEHTLKGFSDFLESHIKTKIEDE 500
>gi|151101292 thioredoxin domain containing 1 [Homo sapiens]
Length = 280
Score = 53.1 bits (126), Expect = 3e-07
Identities = 30/89 (33%), Positives = 45/89 (50%), Gaps = 2/89 (2%)
Query: 97 QGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPT 156
+GD I+F+APWC C+ L P WE A E E V I KVD T+ L + PT
Sbjct: 44 EGDWMIEFYAPWCPACQNLQPEWESFAEWGEDLE-VNIAKVDVTEQPGLSGRFIITALPT 102
Query: 157 LLWFRDGKKVDQYKGKRDLESLREYVESQ 185
+ +DG + +Y+G R + ++ +
Sbjct: 103 IYHCKDG-EFRRYQGPRTKKDFINFISDK 130
Score = 52.8 bits (125), Expect = 4e-07
Identities = 27/86 (31%), Positives = 46/86 (53%), Gaps = 3/86 (3%)
Query: 213 KGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVD 272
+ V +T+ N+ + + EG I+FYAPWC C+ L P WE + E+ V IA+VD
Sbjct: 28 RSNVRVITDENWRELL-EGDWMIEFYAPWCPACQNLQPEWESFA--EWGEDLEVNIAKVD 84
Query: 273 CTAERNICSKYSVRGYPTLLLFRGGK 298
T + + ++ + PT+ + G+
Sbjct: 85 VTEQPGLSGRFIITALPTIYHCKDGE 110
Score = 30.4 bits (67), Expect = 2.2
Identities = 19/55 (34%), Positives = 28/55 (50%), Gaps = 1/55 (1%)
Query: 2 EDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWM 56
ED +V +AKVD T + + PT+ K G E +YQGPR + N++
Sbjct: 74 EDLEVNIAKVDVTEQPGLSGRFIITALPTIYHCKDG-EFRRYQGPRTKKDFINFI 127
>gi|40254947 thioredoxin-related transmembrane protein 4 [Homo
sapiens]
Length = 349
Score = 53.1 bits (126), Expect = 3e-07
Identities = 39/125 (31%), Positives = 58/125 (46%), Gaps = 8/125 (6%)
Query: 67 PEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGL 126
PE PP ++ ++ASN+ L V +G+ +KF+APWC C+ WE A
Sbjct: 27 PEEAALPPEQSRVQP----MTASNWTL-VMEGEWMLKFYAPWCPSCQQTDSEWEAFAKNG 81
Query: 127 EHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYV-ESQ 185
E + + +GKVD Q L V P +DG +Y+G E L+ Y+ E +
Sbjct: 82 EILQ-ISVGKVDVIQEPGLSGRFFVTTLPAFFHAKDG-IFRRYRGPGIFEDLQNYILEKK 139
Query: 186 LQRTE 190
Q E
Sbjct: 140 WQSVE 144
Score = 43.5 bits (101), Expect = 3e-04
Identities = 29/102 (28%), Positives = 45/102 (44%), Gaps = 8/102 (7%)
Query: 196 TVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEEL 255
T P EA A PE + V +T +N+ + EG +KFYAPWC C+ WE
Sbjct: 24 TAGPEEA---ALPPEQSR--VQPMTASNWT-LVMEGEWMLKFYAPWCPSCQQTDSEWEAF 77
Query: 256 SKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGG 297
+K + + + +VD E + ++ V P + G
Sbjct: 78 AKN--GEILQISVGKVDVIQEPGLSGRFFVTTLPAFFHAKDG 117
>gi|50592994 thioredoxin [Homo sapiens]
Length = 105
Score = 51.2 bits (121), Expect = 1e-06
Identities = 27/80 (33%), Positives = 41/80 (51%), Gaps = 4/80 (5%)
Query: 226 DTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSV 285
D + + + F A WCG CK + P + LS+K + V EVD +++ S+ V
Sbjct: 16 DAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEK----YSNVIFLEVDVDDCQDVASECEV 71
Query: 286 RGYPTLLLFRGGKKVSEHSG 305
+ PT F+ G+KV E SG
Sbjct: 72 KCMPTFQFFKKGQKVGEFSG 91
Score = 43.1 bits (100), Expect = 3e-04
Identities = 28/86 (32%), Positives = 43/86 (50%), Gaps = 7/86 (8%)
Query: 96 AQGDHFI--KFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRG 153
A GD + F A WCG CK + P + L+ E V +VD ++ S +V+
Sbjct: 17 AAGDKLVVVDFSATWCGPCKMIKPFFHSLS---EKYSNVIFLEVDVDDCQDVASECEVKC 73
Query: 154 YPTLLWFRDGKKVDQYKG--KRDLES 177
PT +F+ G+KV ++ G K LE+
Sbjct: 74 MPTFQFFKKGQKVGEFSGANKEKLEA 99
>gi|4759274 thioredoxin-like 1 [Homo sapiens]
Length = 289
Score = 47.8 bits (112), Expect = 1e-05
Identities = 44/177 (24%), Positives = 79/177 (44%), Gaps = 26/177 (14%)
Query: 63 EPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQL 122
+PV +P+ +P ELS + L V +KF CG C +AP + +
Sbjct: 5 KPVGSDPDFQP-----------ELSGAGSRLAV------VKFTMRGCGPCLRIAPAFSSM 47
Query: 123 ALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYV 182
+ ++ + V + +VD Q + N + PT L+FR+ ++DQY+G D L E +
Sbjct: 48 SN--KYPQAVFL-EVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQG-ADAVGLEEKI 103
Query: 183 ESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENN---FDDTIAEGITFIK 236
+ L+ +T P + P +K L E++ FD+ + + TF++
Sbjct: 104 KQHLENDPGSNEDTDIPK--GYMDLMPFINKAGCECLNESDEHGFDNCLRKDTTFLE 158
Score = 33.9 bits (76), Expect = 0.20
Identities = 19/74 (25%), Positives = 33/74 (44%), Gaps = 4/74 (5%)
Query: 232 ITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTL 291
+ +KF CG C +AP + +S K +P EVD + + ++ PT
Sbjct: 24 LAVVKFTMRGCGPCLRIAPAFSSMSNK-YPQAV---FLEVDVHQCQGTAATNNISATPTF 79
Query: 292 LLFRGGKKVSEHSG 305
L FR ++ ++ G
Sbjct: 80 LFFRNKVRIDQYQG 93
>gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo
sapiens]
Length = 486
Score = 46.6 bits (109), Expect = 3e-05
Identities = 36/121 (29%), Positives = 56/121 (46%), Gaps = 15/121 (12%)
Query: 195 ETVTPS-EAPVLAAE------PEADKGTVLALTENNFDDTIAEG---ITFIKFYAPWCGH 244
E TPS E +L E PE DK V+ L++ +F+ ++ E + + F A WCG
Sbjct: 357 EEATPSKEGDILKPEEETMEFPEGDKVKVI-LSKEDFEASLKEAGERLVAVDFSATWCGP 415
Query: 245 CKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHS 304
C+T+ P + LS K V EVD + + ++ PT ++ +KV E
Sbjct: 416 CRTIRPFFHALSVKH----EDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELC 471
Query: 305 G 305
G
Sbjct: 472 G 472
Score = 42.0 bits (97), Expect = 7e-04
Identities = 32/116 (27%), Positives = 55/116 (47%), Gaps = 8/116 (6%)
Query: 68 EPEVEPPSAPELKQGLYELSASNFELHVAQGDH---FIKFFAPWCGHCKALAPTWEQLAL 124
+PE E PE + LS +FE + + + F A WCG C+ + P + AL
Sbjct: 369 KPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFH--AL 426
Query: 125 GLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKG--KRDLESL 178
++H + V + +VD E+ + PT +++ +KVD+ G K LE++
Sbjct: 427 SVKHEDVVFL-EVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGALKEKLEAV 481
>gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo
sapiens]
Length = 553
Score = 46.6 bits (109), Expect = 3e-05
Identities = 36/121 (29%), Positives = 56/121 (46%), Gaps = 15/121 (12%)
Query: 195 ETVTPS-EAPVLAAE------PEADKGTVLALTENNFDDTIAEG---ITFIKFYAPWCGH 244
E TPS E +L E PE DK V+ L++ +F+ ++ E + + F A WCG
Sbjct: 424 EEATPSKEGDILKPEEETMEFPEGDKVKVI-LSKEDFEASLKEAGERLVAVDFSATWCGP 482
Query: 245 CKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHS 304
C+T+ P + LS K V EVD + + ++ PT ++ +KV E
Sbjct: 483 CRTIRPFFHALSVKH----EDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELC 538
Query: 305 G 305
G
Sbjct: 539 G 539
Score = 42.0 bits (97), Expect = 7e-04
Identities = 32/116 (27%), Positives = 55/116 (47%), Gaps = 8/116 (6%)
Query: 68 EPEVEPPSAPELKQGLYELSASNFELHVAQGDH---FIKFFAPWCGHCKALAPTWEQLAL 124
+PE E PE + LS +FE + + + F A WCG C+ + P + AL
Sbjct: 436 KPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFH--AL 493
Query: 125 GLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKG--KRDLESL 178
++H + V + +VD E+ + PT +++ +KVD+ G K LE++
Sbjct: 494 SVKHEDVVFL-EVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGALKEKLEAV 548
>gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo
sapiens]
Length = 486
Score = 46.6 bits (109), Expect = 3e-05
Identities = 36/121 (29%), Positives = 56/121 (46%), Gaps = 15/121 (12%)
Query: 195 ETVTPS-EAPVLAAE------PEADKGTVLALTENNFDDTIAEG---ITFIKFYAPWCGH 244
E TPS E +L E PE DK V+ L++ +F+ ++ E + + F A WCG
Sbjct: 357 EEATPSKEGDILKPEEETMEFPEGDKVKVI-LSKEDFEASLKEAGERLVAVDFSATWCGP 415
Query: 245 CKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHS 304
C+T+ P + LS K V EVD + + ++ PT ++ +KV E
Sbjct: 416 CRTIRPFFHALSVKH----EDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELC 471
Query: 305 G 305
G
Sbjct: 472 G 472
Score = 42.0 bits (97), Expect = 7e-04
Identities = 32/116 (27%), Positives = 55/116 (47%), Gaps = 8/116 (6%)
Query: 68 EPEVEPPSAPELKQGLYELSASNFELHVAQGDH---FIKFFAPWCGHCKALAPTWEQLAL 124
+PE E PE + LS +FE + + + F A WCG C+ + P + AL
Sbjct: 369 KPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFH--AL 426
Query: 125 GLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKG--KRDLESL 178
++H + V + +VD E+ + PT +++ +KVD+ G K LE++
Sbjct: 427 SVKHEDVVFL-EVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGALKEKLEAV 481
>gi|237648961 thioredoxin domain containing 16 isoform 2 [Homo
sapiens]
Length = 820
Score = 46.2 bits (108), Expect = 4e-05
Identities = 21/99 (21%), Positives = 47/99 (47%)
Query: 85 ELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYE 144
EL+ F V D + F+A W A ++ +A+ L+ + T+ + +++C +
Sbjct: 390 ELTEETFNATVMASDSIVLFYAGWQAVSMAFLQSYIDVAVKLKGTSTMLLTRINCADWSD 449
Query: 145 LCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVE 183
+C+ V +P + ++ G+ Y G E L ++++
Sbjct: 450 VCTKQNVTEFPIIKMYKKGENPVSYAGMLGTEDLLKFIQ 488
Score = 42.7 bits (99), Expect = 4e-04
Identities = 20/98 (20%), Positives = 49/98 (50%), Gaps = 1/98 (1%)
Query: 219 LTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERN 278
LTE F+ T+ + + FYA W ++ +++ K G + + + ++C +
Sbjct: 391 LTEETFNATVMASDSIVLFYAGWQAVSMAFLQSYIDVAVK-LKGTSTMLLTRINCADWSD 449
Query: 279 ICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFV 316
+C+K +V +P + +++ G+ ++G + L +F+
Sbjct: 450 VCTKQNVTEFPIIKMYKKGENPVSYAGMLGTEDLLKFI 487
Score = 38.9 bits (89), Expect = 0.006
Identities = 14/38 (36%), Positives = 24/38 (63%)
Query: 8 VAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQG 45
+ +++C SDVC+ Q V +P +K++K G+ V Y G
Sbjct: 439 LTRINCADWSDVCTKQNVTEFPIIKMYKKGENPVSYAG 476
>gi|237648959 thioredoxin domain containing 16 isoform 1 [Homo
sapiens]
Length = 825
Score = 46.2 bits (108), Expect = 4e-05
Identities = 21/99 (21%), Positives = 47/99 (47%)
Query: 85 ELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYE 144
EL+ F V D + F+A W A ++ +A+ L+ + T+ + +++C +
Sbjct: 395 ELTEETFNATVMASDSIVLFYAGWQAVSMAFLQSYIDVAVKLKGTSTMLLTRINCADWSD 454
Query: 145 LCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVE 183
+C+ V +P + ++ G+ Y G E L ++++
Sbjct: 455 VCTKQNVTEFPIIKMYKKGENPVSYAGMLGTEDLLKFIQ 493
Score = 42.7 bits (99), Expect = 4e-04
Identities = 20/98 (20%), Positives = 49/98 (50%), Gaps = 1/98 (1%)
Query: 219 LTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERN 278
LTE F+ T+ + + FYA W ++ +++ K G + + + ++C +
Sbjct: 396 LTEETFNATVMASDSIVLFYAGWQAVSMAFLQSYIDVAVK-LKGTSTMLLTRINCADWSD 454
Query: 279 ICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFV 316
+C+K +V +P + +++ G+ ++G + L +F+
Sbjct: 455 VCTKQNVTEFPIIKMYKKGENPVSYAGMLGTEDLLKFI 492
Score = 38.9 bits (89), Expect = 0.006
Identities = 14/38 (36%), Positives = 24/38 (63%)
Query: 8 VAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQG 45
+ +++C SDVC+ Q V +P +K++K G+ V Y G
Sbjct: 444 LTRINCADWSDVCTKQNVTEFPIIKMYKKGENPVSYAG 481
>gi|94421469 disulfide isomerase [Homo sapiens]
Length = 360
Score = 45.4 bits (106), Expect = 7e-05
Identities = 36/151 (23%), Positives = 68/151 (45%), Gaps = 16/151 (10%)
Query: 181 YVESQLQRTETGATETVTPSEA---PVLAAEPEADKGT------VLALTENNFDDTIAEG 231
Y E ++ ++ TE +E+ P + E G +L ++++ D G
Sbjct: 148 YTEPEVAESDAAPTEDSNNTESLKSPKVNCEERNITGLENFTLKILNMSQDLMDFLNPNG 207
Query: 232 --ITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYP 289
T + FY PWC +LAP + L + FP L +D + ++ +++ P
Sbjct: 208 SDCTLVLFYTPWCRFSASLAPHFNSL-PRAFPAL---HFLALDASQHSSLSTRFGTVAVP 263
Query: 290 TLLLFRGGKKVSE-HSGGRDLDSLHRFVLSQ 319
+LLF+G K ++ + R L++L F+ +Q
Sbjct: 264 NILLFQGAKPMARFNHTDRTLETLKIFIFNQ 294
Score = 33.9 bits (76), Expect = 0.20
Identities = 26/109 (23%), Positives = 48/109 (44%), Gaps = 7/109 (6%)
Query: 102 IKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFR 161
+ F+ PWC +LAP + L + +D +QH L + P +L F+
Sbjct: 213 VLFYTPWCRFSASLAPHFNSLPRAF---PALHFLALDASQHSSLSTRFGTVAVPNILLFQ 269
Query: 162 DGKKVDQYK-GKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEP 209
K + ++ R LE+L+ ++ +Q T A + V ++A + P
Sbjct: 270 GAKPMARFNHTDRTLETLKIFIFNQ---TGIEAKKNVVVTQADQIGPLP 315
>gi|221136993 thioredoxin domain containing 14 isoform 2 [Homo
sapiens]
Length = 258
Score = 43.1 bits (100), Expect = 3e-04
Identities = 22/71 (30%), Positives = 39/71 (54%), Gaps = 8/71 (11%)
Query: 235 IKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSV------RGY 288
++F+A W C++ AP + +LS K G+ +VD ++ ++Y V +
Sbjct: 122 VEFFANWSNDCQSFAPIYADLSLKY--NCTGLNFGKVDVGRYTDVSTRYKVSTSPLTKQL 179
Query: 289 PTLLLFRGGKK 299
PTL+LF+GGK+
Sbjct: 180 PTLILFQGGKE 190
Score = 37.4 bits (85), Expect = 0.018
Identities = 21/70 (30%), Positives = 38/70 (54%), Gaps = 7/70 (10%)
Query: 102 IKFFAPWCGHCKALAPTWEQLAL-----GLEHSETVKIGK-VDCTQHYELCSGNQVRGYP 155
++FFA W C++ AP + L+L GL + V +G+ D + Y++ + + P
Sbjct: 122 VEFFANWSNDCQSFAPIYADLSLKYNCTGLNFGK-VDVGRYTDVSTRYKVSTSPLTKQLP 180
Query: 156 TLLWFRDGKK 165
TL+ F+ GK+
Sbjct: 181 TLILFQGGKE 190
>gi|7705726 thioredoxin domain containing 14 isoform 1 [Homo
sapiens]
Length = 296
Score = 43.1 bits (100), Expect = 3e-04
Identities = 22/71 (30%), Positives = 39/71 (54%), Gaps = 8/71 (11%)
Query: 235 IKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSV------RGY 288
++F+A W C++ AP + +LS K G+ +VD ++ ++Y V +
Sbjct: 160 VEFFANWSNDCQSFAPIYADLSLKY--NCTGLNFGKVDVGRYTDVSTRYKVSTSPLTKQL 217
Query: 289 PTLLLFRGGKK 299
PTL+LF+GGK+
Sbjct: 218 PTLILFQGGKE 228
Score = 37.4 bits (85), Expect = 0.018
Identities = 21/70 (30%), Positives = 38/70 (54%), Gaps = 7/70 (10%)
Query: 102 IKFFAPWCGHCKALAPTWEQLAL-----GLEHSETVKIGK-VDCTQHYELCSGNQVRGYP 155
++FFA W C++ AP + L+L GL + V +G+ D + Y++ + + P
Sbjct: 160 VEFFANWSNDCQSFAPIYADLSLKYNCTGLNFGK-VDVGRYTDVSTRYKVSTSPLTKQLP 218
Query: 156 TLLWFRDGKK 165
TL+ F+ GK+
Sbjct: 219 TLILFQGGKE 228
>gi|95113651 glutaredoxin 3 [Homo sapiens]
Length = 335
Score = 42.0 bits (97), Expect = 7e-04
Identities = 28/106 (26%), Positives = 44/106 (41%), Gaps = 9/106 (8%)
Query: 200 SEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKE 259
+EA V A E G L A+ + + F+APW C + EL+ KE
Sbjct: 6 AEAAVAAVEEVGSAGQFEELLRLK-----AKSLLVVHFWAPWAPQCAQMNEVMAELA-KE 59
Query: 260 FPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSG 305
P ++ VK+ + + KY + PT L F+ +K+ G
Sbjct: 60 LPQVSFVKL---EAEGVPEVSEKYEISSVPTFLFFKNSQKIDRLDG 102
Score = 37.4 bits (85), Expect = 0.018
Identities = 21/73 (28%), Positives = 36/73 (49%), Gaps = 9/73 (12%)
Query: 102 IKFFAPWCGHCKALAPTWEQLALGLEHSETVKI---GKVDCTQHYELCSGNQVRGYPTLL 158
+ F+APW C + +LA L VK+ G + ++ YE+ S PT L
Sbjct: 36 VHFWAPWAPQCAQMNEVMAELAKELPQVSFVKLEAEGVPEVSEKYEISS------VPTFL 89
Query: 159 WFRDGKKVDQYKG 171
+F++ +K+D+ G
Sbjct: 90 FFKNSQKIDRLDG 102
>gi|54633317 thioredoxin domain containing 11 [Homo sapiens]
Length = 958
Score = 38.5 bits (88), Expect = 0.008
Identities = 23/75 (30%), Positives = 42/75 (56%), Gaps = 2/75 (2%)
Query: 91 FELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQ 150
+E+ + + D + ++APWCG C +L + QLA L +T + ++D +Q+ +L
Sbjct: 674 WEVVLQKQDVLLLYYAPWCGFCPSLNHIFIQLARNLP-MDTFTVARIDVSQN-DLPWEFM 731
Query: 151 VRGYPTLLWFRDGKK 165
V PT+L+F +K
Sbjct: 732 VDRLPTVLFFPCNRK 746
Score = 32.7 bits (73), Expect = 0.45
Identities = 25/102 (24%), Positives = 50/102 (49%), Gaps = 7/102 (6%)
Query: 220 TENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNI 279
T+ ++ + + + +YAPWCG C +L + +L+ + P + +A +D ++ ++
Sbjct: 670 TDTFWEVVLQKQDVLLLYYAPWCGFCPSLNHIFIQLA-RNLP-MDTFTVARID-VSQNDL 726
Query: 280 CSKYSVRGYPTLLLFRGGKKVSEHSGGRD----LDSLHRFVL 317
++ V PT+L F +K D L +L RF+L
Sbjct: 727 PWEFMVDRLPTVLFFPCNRKDLSVKYPEDVPITLPNLLRFIL 768
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,536,517
Number of Sequences: 37866
Number of extensions: 632805
Number of successful extensions: 2519
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 2257
Number of HSP's gapped (non-prelim): 217
length of query: 324
length of database: 18,247,518
effective HSP length: 102
effective length of query: 222
effective length of database: 14,385,186
effective search space: 3193511292
effective search space used: 3193511292
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.