Guide to the Human Genome
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Search of human proteins with 224451135

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|224451135 splicing factor, arginine/serine-rich 15 isoform 3
[Homo sapiens]
         (1125 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|224451135 splicing factor, arginine/serine-rich 15 isoform 3 ...  2333   0.0  
gi|40789229 splicing factor, arginine/serine-rich 15 isoform 1 [...  2320   0.0  
gi|224451133 splicing factor, arginine/serine-rich 15 isoform 2 ...  2281   0.0  
gi|62460633 RNA-binding motif protein 16 [Homo sapiens]               672   0.0  
gi|160707881 formin 2 [Homo sapiens]                                  122   1e-27
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...   122   2e-27
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]    114   4e-25
gi|4826998 splicing factor proline/glutamine rich (polypyrimidin...   107   5e-23
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ...   104   5e-22
gi|47132519 Ras association and pleckstrin homology domains 1 is...   103   7e-22
gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1 pre...   103   7e-22
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]                    102   2e-21
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]                    102   2e-21
gi|162329583 cleavage and polyadenylation specific factor 6, 68 ...   102   2e-21
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...   102   2e-21
gi|72004269 tetra-peptide repeat homeobox [Homo sapiens]               98   5e-20
gi|146134388 YLP motif containing 1 [Homo sapiens]                     97   9e-20
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    97   1e-19
gi|5032069 splicing factor 3b, subunit 4 [Homo sapiens]                97   1e-19
gi|21361376 splicing factor 3a, subunit 2 [Homo sapiens]               97   1e-19
gi|163965366 nascent polypeptide-associated complex alpha subuni...    97   1e-19
gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]          96   1e-19
gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]          96   1e-19
gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]          96   1e-19
gi|151301053 RNA binding motif protein 33 [Homo sapiens]               96   2e-19
gi|71044479 death inducer-obliterator 1 isoform c [Homo sapiens]       94   9e-19
gi|150170670 piccolo isoform 2 [Homo sapiens]                          91   5e-18
gi|150378539 piccolo isoform 1 [Homo sapiens]                          91   5e-18
gi|122937496 WAS/WASL interacting protein family, member 3 [Homo...    91   5e-18
gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]       91   6e-18

>gi|224451135 splicing factor, arginine/serine-rich 15 isoform 3 [Homo
            sapiens]
          Length = 1125

 Score = 2333 bits (6047), Expect = 0.0
 Identities = 1125/1125 (100%), Positives = 1125/1125 (100%)

Query: 1    MDAVNAFNQELFSLMDMKPPISRAKMILITKAAIKAIKLYKHVVQIVEKFIKKCKPEYKV 60
            MDAVNAFNQELFSLMDMKPPISRAKMILITKAAIKAIKLYKHVVQIVEKFIKKCKPEYKV
Sbjct: 1    MDAVNAFNQELFSLMDMKPPISRAKMILITKAAIKAIKLYKHVVQIVEKFIKKCKPEYKV 60

Query: 61   PGLYVIDSIVRQSRHQFGTDKDVFGPRFSKNITATFQYLYLCPSEDKSKIVRVLNLWQKN 120
            PGLYVIDSIVRQSRHQFGTDKDVFGPRFSKNITATFQYLYLCPSEDKSKIVRVLNLWQKN
Sbjct: 61   PGLYVIDSIVRQSRHQFGTDKDVFGPRFSKNITATFQYLYLCPSEDKSKIVRVLNLWQKN 120

Query: 121  GVFKIEIIQPLLDMAAGTSNAAPVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQL 180
            GVFKIEIIQPLLDMAAGTSNAAPVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQL
Sbjct: 121  GVFKIEIIQPLLDMAAGTSNAAPVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQL 180

Query: 181  PSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQ 240
            PSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQ
Sbjct: 181  PSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQ 240

Query: 241  PSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTA 300
            PSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTA
Sbjct: 241  PSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTA 300

Query: 301  TVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLP 360
            TVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLP
Sbjct: 301  TVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLP 360

Query: 361  PNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEMEVEQPC 420
            PNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEMEVEQPC
Sbjct: 361  PNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEMEVEQPC 420

Query: 421  IQEVKRHMSDNRKSRSRSASRSPKRRRSRSGSRSRRSRHRRSRSRSRDRRRHSPRSRSQE 480
            IQEVKRHMSDNRKSRSRSASRSPKRRRSRSGSRSRRSRHRRSRSRSRDRRRHSPRSRSQE
Sbjct: 421  IQEVKRHMSDNRKSRSRSASRSPKRRRSRSGSRSRRSRHRRSRSRSRDRRRHSPRSRSQE 480

Query: 481  RRDREKERERRQKGLPQVKPETASVCSTTLWVGQLDKRTTQQDVASLLEEFGPIESINMI 540
            RRDREKERERRQKGLPQVKPETASVCSTTLWVGQLDKRTTQQDVASLLEEFGPIESINMI
Sbjct: 481  RRDREKERERRQKGLPQVKPETASVCSTTLWVGQLDKRTTQQDVASLLEEFGPIESINMI 540

Query: 541  PPRGCAYIVMVHRQDAYRALQKLSRGNYKVNQKSIKIAWALNKGIKADYKQYWDVELGVT 600
            PPRGCAYIVMVHRQDAYRALQKLSRGNYKVNQKSIKIAWALNKGIKADYKQYWDVELGVT
Sbjct: 541  PPRGCAYIVMVHRQDAYRALQKLSRGNYKVNQKSIKIAWALNKGIKADYKQYWDVELGVT 600

Query: 601  YIPWDKVKPEELESFCEGGMLDSDTLNPDWKGIPKKPENEVAQNGGAETSHTEPVSPIPK 660
            YIPWDKVKPEELESFCEGGMLDSDTLNPDWKGIPKKPENEVAQNGGAETSHTEPVSPIPK
Sbjct: 601  YIPWDKVKPEELESFCEGGMLDSDTLNPDWKGIPKKPENEVAQNGGAETSHTEPVSPIPK 660

Query: 661  PLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPP 720
            PLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPP
Sbjct: 661  PLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPP 720

Query: 721  PPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSV 780
            PPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSV
Sbjct: 721  PPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSV 780

Query: 781  KMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRP 840
            KMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRP
Sbjct: 781  KMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRP 840

Query: 841  PGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMP 900
            PGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMP
Sbjct: 841  PGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMP 900

Query: 901  GLGGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQPQQ 960
            GLGGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQPQQ
Sbjct: 901  GLGGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQPQQ 960

Query: 961  FRNDNRQQFNSGRDQERFGRRSFGNRVENDRERYGNRNDDRDNSNRDRREWGRRSPDRDR 1020
            FRNDNRQQFNSGRDQERFGRRSFGNRVENDRERYGNRNDDRDNSNRDRREWGRRSPDRDR
Sbjct: 961  FRNDNRQQFNSGRDQERFGRRSFGNRVENDRERYGNRNDDRDNSNRDRREWGRRSPDRDR 1020

Query: 1021 HRDLEERNRRSSGHRDRERDSRDRESRREKEEARGKEKPEVTDRAGGNKTVEPPISQVGN 1080
            HRDLEERNRRSSGHRDRERDSRDRESRREKEEARGKEKPEVTDRAGGNKTVEPPISQVGN
Sbjct: 1021 HRDLEERNRRSSGHRDRERDSRDRESRREKEEARGKEKPEVTDRAGGNKTVEPPISQVGN 1080

Query: 1081 VDTASELEKGVSEAAVLKPSEELPAEATSSVEPEKDSGSAAEAPR 1125
            VDTASELEKGVSEAAVLKPSEELPAEATSSVEPEKDSGSAAEAPR
Sbjct: 1081 VDTASELEKGVSEAAVLKPSEELPAEATSSVEPEKDSGSAAEAPR 1125


>gi|40789229 splicing factor, arginine/serine-rich 15 isoform 1 [Homo
            sapiens]
          Length = 1147

 Score = 2320 bits (6011), Expect = 0.0
 Identities = 1124/1147 (97%), Positives = 1125/1147 (98%), Gaps = 22/1147 (1%)

Query: 1    MDAVNAFNQELFSLMDMKPPISRAKMILITKAAIKAIKLYKHVVQIVEKFIKKCKPEYKV 60
            MDAVNAFNQELFSLMDMKPPISRAKMILITKAAIKAIKLYKHVVQIVEKFIKKCKPEYKV
Sbjct: 1    MDAVNAFNQELFSLMDMKPPISRAKMILITKAAIKAIKLYKHVVQIVEKFIKKCKPEYKV 60

Query: 61   PGLYVIDSIVRQSRHQFGTDKDVFGPRFSKNITATFQYLYLCPSEDKSKIVRVLNLWQKN 120
            PGLYVIDSIVRQSRHQFGTDKDVFGPRFSKNITATFQYLYLCPSEDKSKIVRVLNLWQKN
Sbjct: 61   PGLYVIDSIVRQSRHQFGTDKDVFGPRFSKNITATFQYLYLCPSEDKSKIVRVLNLWQKN 120

Query: 121  GVFKIEIIQPLLDMAAGTSNAAPVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQL 180
            GVFKIEIIQPLLDMAAGTSNAAPVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQL
Sbjct: 121  GVFKIEIIQPLLDMAAGTSNAAPVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQL 180

Query: 181  PSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQ 240
            PSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQ
Sbjct: 181  PSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQ 240

Query: 241  PSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTA 300
            PSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTA
Sbjct: 241  PSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTA 300

Query: 301  TVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLP 360
            TVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLP
Sbjct: 301  TVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLP 360

Query: 361  PNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEMEVEQPC 420
            PNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEMEVEQPC
Sbjct: 361  PNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEMEVEQPC 420

Query: 421  IQEVKRHMSDNRKSRSRSASRSPKRRRSRSGSRSRRSRHRRSRSRSRDRRRHSPRSRSQE 480
            IQEVKRHMSDNRKSRSRSASRSPKRRRSRSGSRSRRSRHRRSRSRSRDRRRHSPRSRSQE
Sbjct: 421  IQEVKRHMSDNRKSRSRSASRSPKRRRSRSGSRSRRSRHRRSRSRSRDRRRHSPRSRSQE 480

Query: 481  RRDREKERERRQKGLPQVKPETASVCSTTLWVGQLDKRTTQQDVASLLEEFGPIESINMI 540
            RRDREKERERRQKGLPQVKPETASVCSTTLWVGQLDKRTTQQDVASLLEEFGPIESINMI
Sbjct: 481  RRDREKERERRQKGLPQVKPETASVCSTTLWVGQLDKRTTQQDVASLLEEFGPIESINMI 540

Query: 541  PPRGCAYIVMVHRQDAYRALQKLSRGNYKVNQKSIKIAWALNKGIKADYKQYWDVELGVT 600
            PPRGCAYIVMVHRQDAYRALQKLSRGNYKVNQKSIKIAWALNKGIKADYKQYWDVELGVT
Sbjct: 541  PPRGCAYIVMVHRQDAYRALQKLSRGNYKVNQKSIKIAWALNKGIKADYKQYWDVELGVT 600

Query: 601  YIPWDKVKPEELESFCEGGMLDSDTLNPDWKGIPKKPENEVAQNGGAETSHTEPVSPIPK 660
            YIPWDKVKPEELESFCEGGMLDSDTLNPDWKGIPKKPENEVAQNGGAETSHTEPVSPIPK
Sbjct: 601  YIPWDKVKPEELESFCEGGMLDSDTLNPDWKGIPKKPENEVAQNGGAETSHTEPVSPIPK 660

Query: 661  PLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPP 720
            PLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPP
Sbjct: 661  PLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPP 720

Query: 721  PPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPN--------------- 765
            PPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPN               
Sbjct: 721  PPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNSTIAGINEDTTKDLS 780

Query: 766  -------LVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVI 818
                   +VSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVI
Sbjct: 781  IGNPIPTVVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVI 840

Query: 819  GLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMP 878
            GLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMP
Sbjct: 841  GLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMP 900

Query: 879  PPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQ 938
            PPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQ
Sbjct: 901  PPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQ 960

Query: 939  QQQQQQPPPSQQPPPTQQQPQQFRNDNRQQFNSGRDQERFGRRSFGNRVENDRERYGNRN 998
            QQQQQQPPPSQQPPPTQQQPQQFRNDNRQQFNSGRDQERFGRRSFGNRVENDRERYGNRN
Sbjct: 961  QQQQQQPPPSQQPPPTQQQPQQFRNDNRQQFNSGRDQERFGRRSFGNRVENDRERYGNRN 1020

Query: 999  DDRDNSNRDRREWGRRSPDRDRHRDLEERNRRSSGHRDRERDSRDRESRREKEEARGKEK 1058
            DDRDNSNRDRREWGRRSPDRDRHRDLEERNRRSSGHRDRERDSRDRESRREKEEARGKEK
Sbjct: 1021 DDRDNSNRDRREWGRRSPDRDRHRDLEERNRRSSGHRDRERDSRDRESRREKEEARGKEK 1080

Query: 1059 PEVTDRAGGNKTVEPPISQVGNVDTASELEKGVSEAAVLKPSEELPAEATSSVEPEKDSG 1118
            PEVTDRAGGNKTVEPPISQVGNVDTASELEKGVSEAAVLKPSEELPAEATSSVEPEKDSG
Sbjct: 1081 PEVTDRAGGNKTVEPPISQVGNVDTASELEKGVSEAAVLKPSEELPAEATSSVEPEKDSG 1140

Query: 1119 SAAEAPR 1125
            SAAEAPR
Sbjct: 1141 SAAEAPR 1147


>gi|224451133 splicing factor, arginine/serine-rich 15 isoform 2 [Homo
            sapiens]
          Length = 1132

 Score = 2281 bits (5910), Expect = 0.0
 Identities = 1109/1147 (96%), Positives = 1110/1147 (96%), Gaps = 37/1147 (3%)

Query: 1    MDAVNAFNQELFSLMDMKPPISRAKMILITKAAIKAIKLYKHVVQIVEKFIKKCKPEYKV 60
            MDAVNAFNQELFSLMDMKPPISRAKMILITKAAIKAIK               CKPEYKV
Sbjct: 1    MDAVNAFNQELFSLMDMKPPISRAKMILITKAAIKAIK---------------CKPEYKV 45

Query: 61   PGLYVIDSIVRQSRHQFGTDKDVFGPRFSKNITATFQYLYLCPSEDKSKIVRVLNLWQKN 120
            PGLYVIDSIVRQSRHQFGTDKDVFGPRFSKNITATFQYLYLCPSEDKSKIVRVLNLWQKN
Sbjct: 46   PGLYVIDSIVRQSRHQFGTDKDVFGPRFSKNITATFQYLYLCPSEDKSKIVRVLNLWQKN 105

Query: 121  GVFKIEIIQPLLDMAAGTSNAAPVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQL 180
            GVFKIEIIQPLLDMAAGTSNAAPVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQL
Sbjct: 106  GVFKIEIIQPLLDMAAGTSNAAPVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQL 165

Query: 181  PSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQ 240
            PSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQ
Sbjct: 166  PSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQ 225

Query: 241  PSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTA 300
            PSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTA
Sbjct: 226  PSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTA 285

Query: 301  TVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLP 360
            TVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLP
Sbjct: 286  TVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLP 345

Query: 361  PNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEMEVEQPC 420
            PNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEMEVEQPC
Sbjct: 346  PNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEMEVEQPC 405

Query: 421  IQEVKRHMSDNRKSRSRSASRSPKRRRSRSGSRSRRSRHRRSRSRSRDRRRHSPRSRSQE 480
            IQEVKRHMSDNRKSRSRSASRSPKRRRSRSGSRSRRSRHRRSRSRSRDRRRHSPRSRSQE
Sbjct: 406  IQEVKRHMSDNRKSRSRSASRSPKRRRSRSGSRSRRSRHRRSRSRSRDRRRHSPRSRSQE 465

Query: 481  RRDREKERERRQKGLPQVKPETASVCSTTLWVGQLDKRTTQQDVASLLEEFGPIESINMI 540
            RRDREKERERRQKGLPQVKPETASVCSTTLWVGQLDKRTTQQDVASLLEEFGPIESINMI
Sbjct: 466  RRDREKERERRQKGLPQVKPETASVCSTTLWVGQLDKRTTQQDVASLLEEFGPIESINMI 525

Query: 541  PPRGCAYIVMVHRQDAYRALQKLSRGNYKVNQKSIKIAWALNKGIKADYKQYWDVELGVT 600
            PPRGCAYIVMVHRQDAYRALQKLSRGNYKVNQKSIKIAWALNKGIKADYKQYWDVELGVT
Sbjct: 526  PPRGCAYIVMVHRQDAYRALQKLSRGNYKVNQKSIKIAWALNKGIKADYKQYWDVELGVT 585

Query: 601  YIPWDKVKPEELESFCEGGMLDSDTLNPDWKGIPKKPENEVAQNGGAETSHTEPVSPIPK 660
            YIPWDKVKPEELESFCEGGMLDSDTLNPDWKGIPKKPENEVAQNGGAETSHTEPVSPIPK
Sbjct: 586  YIPWDKVKPEELESFCEGGMLDSDTLNPDWKGIPKKPENEVAQNGGAETSHTEPVSPIPK 645

Query: 661  PLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPP 720
            PLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPP
Sbjct: 646  PLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPP 705

Query: 721  PPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPN--------------- 765
            PPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPN               
Sbjct: 706  PPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNSTIAGINEDTTKDLS 765

Query: 766  -------LVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVI 818
                   +VSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVI
Sbjct: 766  IGNPIPTVVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVI 825

Query: 819  GLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMP 878
            GLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMP
Sbjct: 826  GLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMP 885

Query: 879  PPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQ 938
            PPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQ
Sbjct: 886  PPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQ 945

Query: 939  QQQQQQPPPSQQPPPTQQQPQQFRNDNRQQFNSGRDQERFGRRSFGNRVENDRERYGNRN 998
            QQQQQQPPPSQQPPPTQQQPQQFRNDNRQQFNSGRDQERFGRRSFGNRVENDRERYGNRN
Sbjct: 946  QQQQQQPPPSQQPPPTQQQPQQFRNDNRQQFNSGRDQERFGRRSFGNRVENDRERYGNRN 1005

Query: 999  DDRDNSNRDRREWGRRSPDRDRHRDLEERNRRSSGHRDRERDSRDRESRREKEEARGKEK 1058
            DDRDNSNRDRREWGRRSPDRDRHRDLEERNRRSSGHRDRERDSRDRESRREKEEARGKEK
Sbjct: 1006 DDRDNSNRDRREWGRRSPDRDRHRDLEERNRRSSGHRDRERDSRDRESRREKEEARGKEK 1065

Query: 1059 PEVTDRAGGNKTVEPPISQVGNVDTASELEKGVSEAAVLKPSEELPAEATSSVEPEKDSG 1118
            PEVTDRAGGNKTVEPPISQVGNVDTASELEKGVSEAAVLKPSEELPAEATSSVEPEKDSG
Sbjct: 1066 PEVTDRAGGNKTVEPPISQVGNVDTASELEKGVSEAAVLKPSEELPAEATSSVEPEKDSG 1125

Query: 1119 SAAEAPR 1125
            SAAEAPR
Sbjct: 1126 SAAEAPR 1132


>gi|62460633 RNA-binding motif protein 16 [Homo sapiens]
          Length = 1271

 Score =  672 bits (1734), Expect = 0.0
 Identities = 496/1275 (38%), Positives = 645/1275 (50%), Gaps = 277/1275 (21%)

Query: 1    MDAVNAFNQELFSLMDMKPPISRAKMILITKAAIKAIKLYKHVVQIVEKFIKKCKPEYKV 60
            M+AV  FN EL+SL D KPPIS+AKM  ITKAAIKAIK YKHVVQ VEKFI+KCKPEYKV
Sbjct: 1    MEAVKTFNSELYSLNDYKPPISKAKMTQITKAAIKAIKFYKHVVQSVEKFIQKCKPEYKV 60

Query: 61   PGLYVIDSIVRQSRHQFGTDKDVFGPRFSKNITATFQYLYLCPSEDKSKIVRVLNLWQKN 120
            PGLYVIDSIVRQSRHQFG +KDVF PRFS NI +TFQ LY CP +DKSKIVRVLNLWQKN
Sbjct: 61   PGLYVIDSIVRQSRHQFGQEKDVFAPRFSNNIISTFQNLYRCPGDDKSKIVRVLNLWQKN 120

Query: 121  GVFKIEIIQPLLDMAAG------TSNAAPVAENVTNNEGSPPPPVKVSSEPPTQATPNSV 174
             VFK EIIQPLLDMAAG      T   A     ++N  G+P  PV  ++    Q  P+  
Sbjct: 121  NVFKSEIIQPLLDMAAGIPPPVVTPVLASTTTAMSNTPGTPVTPVTPANV--VQGLPD-- 176

Query: 175  PAVPQLPSSDAFAAVAQLFQTTQGQQLQQILQTFQ-QPPKPQSP---ALDNAVMAQVQAI 230
            P V Q+ ++D  AAVAQ+ Q+ QGQQLQQ++QT Q Q  KPQ     ALD  ++ Q+QA+
Sbjct: 177  PWVSQITNTDTLAAVAQILQSPQGQQLQQLIQTLQIQQQKPQPSILQALDAGLVVQLQAL 236

Query: 231  TAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAP 290
            TAQL    T  +       P EQ  +F+KKL+DRFD+ ++ E  EE KKE          
Sbjct: 237  TAQL----TAAAAAANTLTPLEQGVSFNKKLMDRFDFGEDSEHSEEPKKE---------- 282

Query: 291  AAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQ 350
                       +PA+   +  S     + F    + +QQ      QN++  + +++  QQ
Sbjct: 283  -----------IPASQL-SHVSESVNNSIFHQIAEQLQQ------QNLEHLRQQLLEQQQ 324

Query: 351  DPMHHQVPLPPNGQMPGFGL--LPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQK 408
                 Q   P + Q   FG     +P      Q  + P   V        Q Q+  + + 
Sbjct: 325  P----QKATPQDSQEGTFGSEHSASPSQGSSQQHFLEPE--VNLDDSIDIQQQDMDIDEG 378

Query: 409  PHQQEMEVEQPCIQEVKRHMSDNR-KSRSRSASRSPKRRRSRSGSRSRRSRHR-RSRSRS 466
                E EV +   QE K+    +R ++ SRS SRSP++RRSRS S SR+ +HR RSRSRS
Sbjct: 379  QDGVEEEVFE---QEAKKVAVRSRSRTHSRSRSRSPRKRRSRSRSGSRKRKHRKRSRSRS 435

Query: 467  RDRRRHSPRSRSQERRDREKERERRQKGLPQVKPETASVCSTTLWVGQLDKRTTQQDVAS 526
            R+R+R S RS S ERR RE+E+ER++KGLP ++ +T SVCSTTLWVGQ+DK+ TQQD+ +
Sbjct: 436  RERKRKSSRSYSSERRAREREKERQKKGLPPIRSKTLSVCSTTLWVGQVDKKATQQDLTN 495

Query: 527  LLEEFGPIESINMIPPRGCAYIVMVHRQDAYRALQKLSRGNYKVNQKSIKIAWALNKGIK 586
            L EEFG IESINMIPPRGCAY+ MVHRQDA+RALQKLS G+YK+  K IKIAWALNKG+K
Sbjct: 496  LFEEFGQIESINMIPPRGCAYVCMVHRQDAFRALQKLSSGSYKIGSKVIKIAWALNKGVK 555

Query: 587  ADYKQYWDVELGVTYIPWDKVKPEELESFCEGGMLDSDTLNPDWKGI-PKKPENEVAQNG 645
             +YKQ+WDV+LGVTYIPW+KVK ++LE F EGGM+D +T+N +W+ +   +P  E  Q  
Sbjct: 556  TEYKQFWDVDLGVTYIPWEKVKVDDLEGFAEGGMIDQETVNTEWETVKSSEPVKETVQT- 614

Query: 646  GAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLG 705
                  T+  +P+ K   V       P P+ +   Q+P   P  P V +L PPAF   + 
Sbjct: 615  ------TQSPTPVEKETVVTTQAEVFPPPVAM--LQIPV-APAVPTV-SLVPPAFPVSMP 664

Query: 706  IPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPN 765
            +PPPGF      P PPPPFLR  FNP   PPGF+PP  PPP+ PP +IPP     +  P+
Sbjct: 665  VPPPGFS-----PIPPPPFLRASFNPSQPPPGFMPPPVPPPVVPPPTIPPVVPTSLVQPS 719

Query: 766  LVS--------GARGNAESGDSV--KMYGSAVPPAAPTNLPT------------------ 797
            L          G       G SV   +  SA+P     N PT                  
Sbjct: 720  LSMTPETVKDVGFGSLVIPGGSVASNLATSALPAGNVFNAPTKQAEPEEKVPHLIDHQIS 779

Query: 798  ------------------------PPVTQPVSLLGTQ-----------GVAPGPV----- 817
                                    P VT    +LG Q           GV P  V     
Sbjct: 780  SGENTRSVIPNDISSNAAILGGQPPNVTSNSGILGVQRPNVSSNSEILGVRPSNVSSSSG 839

Query: 818  ---------------IGLQAP----STGLLGARP-------GLIPLQRP-----PGM--- 843
                           +G+Q P    S+GLLG  P       GL+ +Q P     PG+   
Sbjct: 840  IIAAQPPNILNNSGILGIQPPSVSNSSGLLGVLPPNIPNNSGLVGVQPPNVPNTPGLLGT 899

Query: 844  -PP------PHL----QRFPLMPPRPMPPHMMHRGPPPG--------PGGFAMPPPHGM- 883
             PP      P L    QR P MP   + P ++ + P P         P    +PPP  + 
Sbjct: 900  QPPAGPQNLPPLSIPNQRMPTMPMLDIRPGLIPQAPGPRFPLIQPGIPPQRGIPPPSVLD 959

Query: 884  -------KGPFP-------PHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQPQQQP 929
                   +GPFP       P  PF+ PG         P    P   D  QQ   +  + P
Sbjct: 960  SALHPPPRGPFPPGDIFSQPERPFLAPGRQSVDNVTNPEKRIPLGNDNIQQEGDRDYRFP 1019

Query: 930  QPQAPQQPQQQQQQQPPPSQ------QPPPTQQQPQQFRNDNRQQFNSGRDQ-------- 975
              +      ++   +PPP        +P   ++ P +   D R  F  GR          
Sbjct: 1020 PIET-----RESISRPPPVDVRDVVGRPIDPREGPGRPPLDGRDHF--GRPPVDIRENLV 1072

Query: 976  ----ERFGRRS-FGNRVENDRERYGNRNDDRDNSNRDRREWG------------------ 1012
                +  GRR  FG    N  + +G+R D  +  +R    +G                  
Sbjct: 1073 RPGIDHLGRRDHFG---FNPEKPWGHRGDFDEREHRVLPVYGGPKGLHEERGRFRSGNYR 1129

Query: 1013 --------RRSPDRDRHRDLEERNRRSSGHRDRERDSRDRESRREKEEAR-GKEKPEVTD 1063
                     R   ++ HRD ++R R     R R+RD RD +  RE    R G+++ +   
Sbjct: 1130 FDPRSGPWNRGFGQEVHRDFDDRRR--PWERQRDRDDRDFDFCREMNGNRLGRDRIQ--- 1184

Query: 1064 RAGGNKTVEPPISQV 1078
                N  V PP ++V
Sbjct: 1185 ----NTWVPPPHARV 1195



 Score = 39.7 bits (91), Expect = 0.016
 Identities = 47/201 (23%), Positives = 77/201 (38%), Gaps = 20/201 (9%)

Query: 926  QQQPQPQAPQQPQQQ---QQQQPPPSQQPPPTQQ---QPQQFRNDN----RQQFNSGRDQ 975
            QQQPQ   PQ  Q+     +    PSQ    +QQ   +P+   +D+    +Q  +    Q
Sbjct: 322  QQQPQKATPQDSQEGTFGSEHSASPSQGS--SQQHFLEPEVNLDDSIDIQQQDMDIDEGQ 379

Query: 976  ERFGRRSFGNRVENDRERYGNRNDDRDNSNRDRREWGRRSPDRDRHRDLEERNRRSSGHR 1035
            +      F    +    R  +R   R  S   R+   RRS  R   R  + R R  S  R
Sbjct: 380  DGVEEEVFEQEAKKVAVRSRSRTHSRSRSRSPRK---RRSRSRSGSRKRKHRKRSRSRSR 436

Query: 1036 DRERD-----SRDRESRREKEEARGKEKPEVTDRAGGNKTVEPPISQVGNVDTASELEKG 1090
            +R+R      S +R +R  ++E + K  P +  +     +    + QV    T  +L   
Sbjct: 437  ERKRKSSRSYSSERRAREREKERQKKGLPPIRSKTLSVCSTTLWVGQVDKKATQQDLTNL 496

Query: 1091 VSEAAVLKPSEELPAEATSSV 1111
              E   ++    +P    + V
Sbjct: 497  FEEFGQIESINMIPPRGCAYV 517


>gi|160707881 formin 2 [Homo sapiens]
          Length = 1722

 Score =  122 bits (307), Expect = 1e-27
 Identities = 119/343 (34%), Positives = 144/343 (41%), Gaps = 68/343 (19%)

Query: 654  PVSPIPKPLPVPVPPIPVPAPIT---VPPPQVPPHQ---PGPPVVGA-LQPPAFTPPLGI 706
            P + IP P P+P   IP+P P+    +PPP   P     P PP+ GA + PP   P  GI
Sbjct: 949  PGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1008

Query: 707  PPPGF--GPGVPPPPP------PPPFLRPGFNPMHLPPGFLPPG---PPPPITPPVSIPP 755
            PPP    G G+PPPPP      PPP   PG     +PP    PG   PPPP  P   IPP
Sbjct: 1009 PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG---IPPPPPLPGAGIPPPPPLPGAGIPP 1065

Query: 756  PHTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAP---TNLPTPPVTQPVSLLGTQGV 812
            P  PP+            A       + G+ +PP  P     +P PP   P+  +G    
Sbjct: 1066 P--PPLP----------GAGIPPPPPLPGAGIPPPPPLPGAGIPPPP---PLPGVGIPPP 1110

Query: 813  APGPVIGLQAPSTGLLGARPGLIPLQRPPGM---PPPHLQRFPLMPPRPM-------PPH 862
             P P  G+  P   L GA  G+ P    PG    PPP L R  + PP P+       PP 
Sbjct: 1111 PPLPGAGIPPPPP-LPGA--GIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPP 1167

Query: 863  MMHRG--PPPGPGGFAMPPPHGMKG---PFPPHGP---FVRPGGMPGLG-GPGPGPGGPE 913
            +   G  PPP   G  +PPP  + G   P PP  P      P  +PG+G  P P P  P 
Sbjct: 1168 LPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPP 1227

Query: 914  DRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQ---QPPP 953
               G   PP  P   P    P  PQ      P P      PPP
Sbjct: 1228 PGTGIPPPPLLPVSGP----PLLPQVGSSTLPTPQVCGFLPPP 1266



 Score =  110 bits (274), Expect = 1e-23
 Identities = 115/348 (33%), Positives = 134/348 (38%), Gaps = 59/348 (16%)

Query: 649  TSHTEPVSPIPKPLPV------PVPPIPVPAPITVPPPQVPPHQ--PGPPVVGALQPPAF 700
            T  T P + IP+P P+      P PP P+P     PPP +P     P PP+ GA  PP  
Sbjct: 887  TVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPP-- 944

Query: 701  TPPLGIPPPGFGPGVPPPPP--------PPPFLRPGF-NPMHLPPGFLPPG--------P 743
                  PPP  G  +PPPPP        PPP    G   P  LP   +PP         P
Sbjct: 945  ------PPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 998

Query: 744  PPPITPPVSIPPPHTPP---ISIPNLVSGARGNAESGDSVKMYGSAVPPAAP---TNLPT 797
            PPP  P   IPPP   P   I  P  + G    A       + G+ +PP  P     +P 
Sbjct: 999  PPPPLPGAGIPPPPPLPGAGIPPPPPLPG----AGIPPPPPLPGAGIPPPPPLPGAGIPP 1054

Query: 798  PPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGM---PPPHLQRFPLM 854
            PP   P+   G     P P  G+  P   L GA  G+ P    PG    PPP L    + 
Sbjct: 1055 PP---PLPGAGIPPPPPLPGAGIPPPPP-LPGA--GIPPPPPLPGAGIPPPPPLPGVGIP 1108

Query: 855  PPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPED 914
            PP P+P   +   PPP PG    PPP       PP  P  R G  P    PG G   P  
Sbjct: 1109 PPPPLPGAGI-PPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPP 1167

Query: 915  RDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQP----PPTQQQP 958
              G   PP  P   P    P  P       PPP   P    PP    P
Sbjct: 1168 LPGAGIPP--PPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLP 1213



 Score =  102 bits (255), Expect = 2e-21
 Identities = 117/364 (32%), Positives = 135/364 (37%), Gaps = 85/364 (23%)

Query: 648  ETSHTEPVSP-------IPKPLPVP-------------VPPIPVPAP-ITVPP------P 680
            +TSH   VS        IP P P+P             VPP P P P +TVP       P
Sbjct: 838  QTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIP 897

Query: 681  QVPPHQ-------PGPPVVGA-LQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPM 732
            Q PP Q       P PP+ GA + PP   P  GI P    PG   PPPPP          
Sbjct: 898  QPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPP---------- 947

Query: 733  HLPPGFLPPGPP--------PPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMYG 784
             LP   +PP PP        PP  P   IPPP  PP+            A       + G
Sbjct: 948  -LPGAAIPPPPPLPGAGIPLPPPLPGAGIPPP--PPLP----------GAGIPPPPPLPG 994

Query: 785  SAVPPAAP---TNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPP 841
            + +PP  P     +P PP   P+   G     P P  G+  P   L GA  G+ P    P
Sbjct: 995  AGIPPPPPLPGAGIPPPP---PLPGAGIPPPPPLPGAGIPPPPP-LPGA--GIPPPPPLP 1048

Query: 842  GM---PPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGG 898
            G    PPP L    + PP P+P   +   PPP PG    PPP       PP  P    G 
Sbjct: 1049 GAGIPPPPPLPGAGIPPPPPLPGAGI-PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGI 1107

Query: 899  MPGLGGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQP----PPT 954
             P    PG G   P    G   PP  P   P    P  P   +   PPP   P    PP 
Sbjct: 1108 PPPPPLPGAGIPPPPPLPGAGIPP--PPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPP 1165

Query: 955  QQQP 958
               P
Sbjct: 1166 PPLP 1169



 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 86/260 (33%), Positives = 104/260 (40%), Gaps = 46/260 (17%)

Query: 632  GIPKKPENEVAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPIT---VPPPQVPPHQ-- 686
            GIP  P        G       P + IP P P+P   IP P P+    +PPP   P    
Sbjct: 1040 GIPPPPP---LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1096

Query: 687  -PGPPVVGA-LQPPAFTPPLGIPPPGF--GPGVPPP--------PPPPPFLRPGFNPMHL 734
             P PP+ G  + PP   P  GIPPP    G G+PPP        PPPPP  R G  P   
Sbjct: 1097 PPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPP 1156

Query: 735  PPGFLPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTN 794
             PG   P PPPP+      PPP  P + IP                 + G  +PP  P  
Sbjct: 1157 LPGAGIP-PPPPLPGAGIPPPPPLPGVGIP-------------PPPPLPGVGIPPPPP-- 1200

Query: 795  LPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLM 854
            LP   +  P  L G  G+ P P   L  P TG+    P L+P+  PP +P       P  
Sbjct: 1201 LPGAGIPPPPPLPG-MGIPPAPAPPLPPPGTGI--PPPPLLPVSGPPLLPQVGSSTLP-- 1255

Query: 855  PPRPMPPHMMHRGPPPGPGG 874
                  P +    PPP P G
Sbjct: 1256 -----TPQVCGFLPPPLPSG 1270



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 74/240 (30%), Positives = 95/240 (39%), Gaps = 71/240 (29%)

Query: 632  GIPKKPENEVAQNGGAETSHTEPVSPIPKPLPVP----VPPIPVPAPITVPPPQVPPH-- 685
            GIP  P        G       P + IP P P+P     PP P+P     PPP +P    
Sbjct: 1117 GIPPPPP---LPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGI 1173

Query: 686  QPGPPVVGA-LQPPAFTPPLGIPPPGF--GPGVPPPPPPPPFLRPGFNPMHLPPGFLPPG 742
             P PP+ G  + PP   P +GIPPP    G G+PPPPP             LP   +PP 
Sbjct: 1174 PPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPP-------------LPGMGIPPA 1220

Query: 743  PPPPITPP-VSIPPPHTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVT 801
            P PP+ PP   IPPP   P+S P L                    +P    + LPTP V 
Sbjct: 1221 PAPPLPPPGTGIPPPPLLPVSGPPL--------------------LPQVGSSTLPTPQVC 1260

Query: 802  QPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPP 861
                     G  P P+       +GL G     + + +  G      ++ P+ P RPM P
Sbjct: 1261 ---------GFLPPPL------PSGLFG-----LGMNQDKGS-----RKQPIEPCRPMKP 1295



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 37/116 (31%), Positives = 44/116 (37%), Gaps = 12/116 (10%)

Query: 290  PAAAVPPAP----TATVPAAAAPAAASPPPPQAPF-------GFPGDGMQQPAYTQHQNM 338
            P A +PP P        P    P A  PPPP  P          PG G+  P       +
Sbjct: 1070 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGI 1129

Query: 339  DQFQPRM-MGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQP 393
                P    GI   P   +V +PP   +PG G+ P PP P    P  PP P V  P
Sbjct: 1130 PPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIP 1185



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 35/109 (32%), Positives = 43/109 (39%), Gaps = 9/109 (8%)

Query: 290  PAAAVPPAP----TATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPR- 344
            P A +PP P        P    P A  PPPP      PG G+  P       +    P  
Sbjct: 1092 PGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPP----LPGAGIPPPPPLPGAGIPPPPPLP 1147

Query: 345  MMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQP 393
             +GI   P      +PP   +PG G+ P PP P +  P  PP P V  P
Sbjct: 1148 RVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIP 1196



 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 37/116 (31%), Positives = 45/116 (38%), Gaps = 13/116 (11%)

Query: 290  PAAAVPPAP----TATVPAAAAPAAASPPPPQAPF-------GFPGDGMQQPAYTQHQNM 338
            P A +PP P        P    P A  PPPP  P          PG G+  P       +
Sbjct: 1114 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGI 1173

Query: 339  DQFQPRM-MGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQP 393
                P   +GI   P    V +PP   +PG G+ P PP P M  P   P PP+  P
Sbjct: 1174 PPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPP-APAPPLPPP 1228



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 35/109 (32%), Positives = 41/109 (37%), Gaps = 9/109 (8%)

Query: 290  PAAAVPPAP----TATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRM 345
            P A +PP P        P    P A  PPPP      PG G+  P       +    P  
Sbjct: 1004 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP----LPGAGIPPPPPLPGAGIPPPPPLP 1059

Query: 346  -MGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQP 393
              GI   P      +PP   +PG G+ P PP P    P  PP P V  P
Sbjct: 1060 GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIP 1108



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 34/111 (30%), Positives = 41/111 (36%), Gaps = 12/111 (10%)

Query: 290  PAAAVPPAP----TATVPAAAAPAAASPPPPQAPFG-------FPGDGMQQPAYTQHQNM 338
            P A +PP P       +P    P A  PPPP  P          PG G+  P       +
Sbjct: 916  PGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGI 975

Query: 339  DQFQPRM-MGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTP 388
                P    GI   P      +PP   +PG G+ P PP P    P  PP P
Sbjct: 976  PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1026



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 34/104 (32%), Positives = 41/104 (39%), Gaps = 9/104 (8%)

Query: 294  VPPAPTATVPAAAA-PAAASPPPPQAPFG-------FPGDGMQQPAYTQHQNMDQFQPRM 345
            +PP P A +P     P AA PPPP  P          PG G+  P       +    P  
Sbjct: 934  LPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLP 993

Query: 346  -MGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTP 388
              GI   P      +PP   +PG G+ P PP P    P  PP P
Sbjct: 994  GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1037



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 66/259 (25%), Positives = 87/259 (33%), Gaps = 35/259 (13%)

Query: 154 SPPPPVKVSSEPPTQATPNSVPAVPQLPSSDA--FAAVAQLFQTTQGQQLQ----QILQT 207
           SP     V + PP    P   P  P   S     F +   L  + +   +Q    Q  Q+
Sbjct: 747 SPTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQS 806

Query: 208 FQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRFDY 267
             QPP P S  L +A   Q  +      +T  Q S + +        +AF          
Sbjct: 807 ISQPPPPPS-LLWSAGQGQPGSQPPHSISTEFQTSHEHSV------SSAFKNSC--NIPS 857

Query: 268 DDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPP-------PQAPF 320
                  E S       +    P    PP P  TVP   + A   PPP       P  P 
Sbjct: 858 PPPLPCTESSSSMPGLGMVPPPP----PPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPP 913

Query: 321 GFPGDGMQQPAYTQHQNMDQFQPRM-MGIQQDPMHHQVPLPPNGQMPGFGL-----LP-- 372
             PG G+  P       +    P    GI   P      +PP   +PG G+     LP  
Sbjct: 914 PLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGA 973

Query: 373 -TPPFPPMAQPVIPPTPPV 390
             PP PP+    IPP PP+
Sbjct: 974 GIPPPPPLPGAGIPPPPPL 992



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 37/113 (32%), Positives = 44/113 (38%), Gaps = 14/113 (12%)

Query: 290  PAAAVPPAP----TATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRM 345
            P A +PP P        P    P A  PPPP      PG G+  P       +    P  
Sbjct: 1136 PGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPP----LPGAGIPPPPPLPGVGIPPPPPLP 1191

Query: 346  -MGIQQDPMHHQVPLPPNGQMPGFGL--LPTPPFPPMAQPVIPPTP--PVQQP 393
             +GI   P      +PP   +PG G+   P PP PP     IPP P  PV  P
Sbjct: 1192 GVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPGTG-IPPPPLLPVSGP 1243



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 63/285 (22%), Positives = 96/285 (33%), Gaps = 58/285 (20%)

Query: 154 SPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQQILQTFQQ--- 210
           S PP  +   E     + ++V   PQ  S      V  +    Q   +QQ+ QT +    
Sbjct: 629 SKPPDEEHRLEDAETESQSAVSETPQKRSDAVQKEVVDMKSEGQATVIQQLEQTIEDLRT 688

Query: 211 ---PPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRFDY 267
                + Q PALD  V +  Q     L+   T   +        E+K     ++L     
Sbjct: 689 KIAELERQYPALDTEVASGHQG----LENGVTASGDVCLEALRLEEKEVRHHRIL----- 739

Query: 268 DDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAP------------------- 308
             E ++++ S  E+   V T  P   +P  P     A + P                   
Sbjct: 740 --EAKSIQTSPTEEG-GVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISV 796

Query: 309 ---------AAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQ--V 357
                    + + PPPP +     G G Q  +   H    +FQ            +   +
Sbjct: 797 QLDSHQPTQSISQPPPPPSLLWSAGQG-QPGSQPPHSISTEFQTSHEHSVSSAFKNSCNI 855

Query: 358 PLPP-------NGQMPGFGLLPTPP--FPPMAQPVIPPTPPVQQP 393
           P PP       +  MPG G++P PP   P M  P +P T   Q P
Sbjct: 856 PSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPP 900



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 36/113 (31%), Positives = 42/113 (37%), Gaps = 23/113 (20%)

Query: 290  PAAAVPPAP----TATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRM 345
            P A +PP P        P    P    PPPP      PG G+  P       +    P  
Sbjct: 1158 PGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPP----LPGVGIPPPPPLPGAGIPPPPPLP 1213

Query: 346  -MGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIP-------PTPPV 390
             MGI   P     PLPP    PG G+ P P  P    P++P       PTP V
Sbjct: 1214 GMGIPPAPAP---PLPP----PGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQV 1259



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 50/185 (27%), Positives = 63/185 (34%), Gaps = 18/185 (9%)

Query: 786 AVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGL-QAP-STGLLGARPGLIPLQRPPGM 843
           A  PAAP   PT    QP + LG      GP  G  +AP S     A   L  L      
Sbjct: 229 AEEPAAP---PTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAA 285

Query: 844 PPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLG 903
            P    R P  PP P    +      P     A   P     PFP  GP     G P  G
Sbjct: 286 EP----REPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRG 341

Query: 904 GPGPGPGGPED--------RDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQ 955
                  G ED          G +  P+  +  PQ +  ++P+++ Q    P+    P  
Sbjct: 342 AGDTDEEGEEDAFEDAPRGSPGEEWAPEVGEDAPQ-RLGEEPEEEAQGPDAPAAASLPGS 400

Query: 956 QQPQQ 960
             P Q
Sbjct: 401 PAPSQ 405



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 20/43 (46%), Positives = 24/43 (55%), Gaps = 2/43 (4%)

Query: 919 QQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQP--PPTQQQPQ 959
           QQ  +  QQQ Q    Q  QQQQQQQ   +++P  PPT   PQ
Sbjct: 200 QQAIRLQQQQQQQLQLQLQQQQQQQQLQGAEEPAAPPTAVSPQ 242


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score =  122 bits (306), Expect = 2e-27
 Identities = 108/356 (30%), Positives = 134/356 (37%), Gaps = 61/356 (17%)

Query: 649 TSHTEPVSPIPKPLPVPVPPIPV-------PAPITVPPPQVPPHQPGPPVVGALQPPAFT 701
           T H E   P P P P+  PP P+       P+ I  PPPQ PP    PP+ G   PP   
Sbjct: 555 TPHLE-TPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPP--L 611

Query: 702 PPLGIPPPGFGPGVPPPP---PPPPFLRPGFNPMHLPPGFLP----------PGPPPPIT 748
            PL  PPP   P +  PP   PP P   P  +P+  P    P          P  PPP +
Sbjct: 612 SPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPP-S 670

Query: 749 PPVSIP--PPHTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSL 806
           PPV  P  PP +PP+S       A   +++  S+      VPP+ P + P  P   P   
Sbjct: 671 PPVQAPFSPPASPPVS-----PSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATP--- 722

Query: 807 LGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLM----PPRPMPPH 862
              Q   P     LQ P +    A P + P   PP   PP L   PL     PP  +P  
Sbjct: 723 -PPQAPPPLAAPPLQVPPSP--PASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMS 779

Query: 863 MMHRGPPPGPGGFAMPPPHGMKGP---FPPHGPFVRPGGMPGLGGPGPGPGGPEDRDG-R 918
            + + PP  P   A PP   +  P   FP   PF     +P      P P  P       
Sbjct: 780 PLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPL 839

Query: 919 QQPPQQPQQQPQPQAPQQPQQQQQQ----------------QPPPSQQPPPTQQQP 958
            Q P  P   P  QAP++P                       PPPS+ P  T   P
Sbjct: 840 LQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGP 895



 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 106/384 (27%), Positives = 137/384 (35%), Gaps = 85/384 (22%)

Query: 609 PEELESFCEGGMLDSDTLNPDWKGIPKKP-ENEVAQNGGAETSHTEPVSP-IPKPLPVPV 666
           P  L S      L S TL      +   P + + +    +  + T P SP +  PL +P 
Sbjct: 406 PLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPA 465

Query: 667 -PPI---------PVPAPITVPPPQ----VPPHQPGPPVVGALQPPAFTPPLGIPPPGFG 712
            PP+         P+ +P+T+ P Q    +  H P  P+   + PP  T     PP    
Sbjct: 466 SPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQT 525

Query: 713 PGVPPPPPP--------PPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIP 764
           P      PP        PP L+    P+  P    PP P P    P+  PP    P++ P
Sbjct: 526 PPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPC---PLQAPPS---PLTTP 579

Query: 765 NLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPS 824
                                  PP  P+++ TPP   P +L      A  P+ GL +P 
Sbjct: 580 -----------------------PPETPSSIATPPPQAPPAL------ASPPLQGLPSPP 610

Query: 825 TGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGP-----PPGPGGFAMPP 879
                    L PL  PP   PP L   PL  P P PP      P     P  P   A+  
Sbjct: 611 ---------LSPLATPPPQAPPXLALPPLQAP-PSPPASPPLSPLATPSPQAPNALAV-- 658

Query: 880 PHGMKGPF-PPHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQ--QPQQQPQPQAPQQ 936
            H ++ PF PP  P V+    P    P   P  P      Q PP    P  Q  P  P  
Sbjct: 659 -HLLQAPFSPPPSPPVQAPFSP----PASPPVSPSATPPSQAPPSLAAPPLQVPPSPPAS 713

Query: 937 PQQQQQQQPPPSQQPPPTQQQPQQ 960
           P       PPP Q PPP    P Q
Sbjct: 714 PPMSPSATPPP-QAPPPLAAPPLQ 736



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 108/410 (26%), Positives = 130/410 (31%), Gaps = 110/410 (26%)

Query: 646 GAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLG 705
           G +     P      PLP  +PP P   P+  P P  PP    PP +  L  P  TPP  
Sbjct: 311 GTKARPVPPPDNAATPLPATLPPSP---PLATPLPLAPPSPSAPPSLQTLPSPPATPPSQ 367

Query: 706 IPPPGFGPGVPPPP-----PP--------PPFLRPGFNPMHLP----------------- 735
            PP    P +  PP     PP         P L+   +P+ L                  
Sbjct: 368 APPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATH 427

Query: 736 -------------------PGFLPPGPPP---PITPPVSIP-----PPHTPPISIP---N 765
                              P   PP  PP   P++ P S P      P   P+S P   +
Sbjct: 428 SFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIH 487

Query: 766 LVSGARGNAESGDSVKMYGSAVPP------AAPTNLPTPP--VTQPVSLLGTQGVAPGPV 817
            +      A       +    +PP       AP +L TPP  +T P  L     +AP P+
Sbjct: 488 PLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTP-PLENLPSLAPPPL 546

Query: 818 IGLQAPSTG---LLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGG 874
               AP T         P   PLQ PP          PL  P P  P  +   PP  P  
Sbjct: 547 QTASAPLTTPHLETPPCPAPCPLQAPPS---------PLTTPPPETPSSIATPPPQAPPA 597

Query: 875 FAMPPPHGMKGPFPPHGPFVRPG-------GMPGLGGPGPGPGGPE----DRDGRQQP-- 921
            A PP  G+  P PP  P   P         +P L  P   P  P          Q P  
Sbjct: 598 LASPPLQGL--PSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNA 655

Query: 922 --------PQQPQQQPQPQAPQQPQQQQQQQP---PPSQQPPPTQQQPQQ 960
                   P  P   P  QAP  P       P   PPSQ PP     P Q
Sbjct: 656 LAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQ 705



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 87/305 (28%), Positives = 109/305 (35%), Gaps = 48/305 (15%)

Query: 637 PENEVAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPPP-QVPPHQPGPPVVGAL 695
           P ++   +  A      P  P   P+     P P   P    PP QVPP  P  P +   
Sbjct: 691 PPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMS-- 748

Query: 696 QPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPP 755
             P+ TPP  +PP    P +  PP PP  L    +P+  PP   P  PP   TPP+   P
Sbjct: 749 --PSATPPPRVPPLLAAPPLQVPPSPPASL--PMSPLAKPP---PQAPPALATPPLQALP 801

Query: 756 PHTPPISIPNLVSGARGNAESGDSVKMYGSAV---PPAAPTNLPTPPVTQPVSLLGTQGV 812
             +PP S P       G A    S  +  S +   PP AP  L  P +  P S   +  +
Sbjct: 802 --SPPASFP-------GQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTL 852

Query: 813 APGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMH------- 865
                     P T + G R  L     PP  PPP       +    +  H          
Sbjct: 853 QAPRRPPTPGPDTSVSGPRLTLALAPGPP--PPPSRSPSSTLSGPDLAGHSSSATSTPEE 910

Query: 866 -RGPPPGP--GGFAMPPPHG----------MKGPFPPHGPFVRPGGMPGLGGPGPGPGGP 912
            RG   GP  G  A PPP             +GP PP    +   G PG   P P   GP
Sbjct: 911 LRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPP----LAFRGAPGAPLPWPPATGP 966

Query: 913 EDRDG 917
              DG
Sbjct: 967 GSADG 971



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 75/293 (25%), Positives = 102/293 (34%), Gaps = 49/293 (16%)

Query: 634 PKKPENEVAQNGGAETSHTEPVSPIPKPLPVPVPPIPVP-APITVPPPQVPPHQPGPPVV 692
           P  P +              P+   P     P PP  +P +P+  PPPQ PP    PP+ 
Sbjct: 739 PSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQ 798

Query: 693 GALQPPA-------FTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGPPP 745
               PPA       F+P   +P     P   PPP  PP L     P+   P      P P
Sbjct: 799 ALPSPPASFPGQAPFSPSASLP---MSPLATPPPQAPPVLAA---PLLQVP------PSP 846

Query: 746 PITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVS 805
           P +P  ++  P  PP   P+        + SG  + +  +  PP  P+  P+  ++ P  
Sbjct: 847 PASP--TLQAPRRPPTPGPD-------TSVSGPRLTLALAPGPPPPPSRSPSSTLSGP-D 896

Query: 806 LLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPR----PMPP 861
           L G    A      L+   +G         P       PPP  +     P      P PP
Sbjct: 897 LAGHSSSATSTPEELRGYDSG---------PEGGAAASPPPDAELAACHPAAWSRGPAPP 947

Query: 862 HMMHRGPP----PGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPG 910
            +  RG P    P P         G+   +   GP       PG   PGP PG
Sbjct: 948 -LAFRGAPGAPLPWPPATGPGSADGLCTIYETEGP-ESATPAPGALDPGPSPG 998



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 78/374 (20%), Positives = 123/374 (32%), Gaps = 92/374 (24%)

Query: 132 LDMAAGTSNAAPVAENVTNNEGSPPPPVKVS-SEPPTQATPN--SVPAV--------PQL 180
           L +A  + +A P  + + +   +PP     S + PP QA P+  ++P +        P L
Sbjct: 341 LPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSL 400

Query: 181 PSSDAFAAVAQL----------------FQTTQGQQLQQILQTFQQPPK----------- 213
            +  +  A++ L                F T   +Q Q  L +  +P             
Sbjct: 401 QAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAP 460

Query: 214 ---PQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRFDYDDE 270
              P SP L  ++   V  +++ L   P Q     A+  P    ++     L+       
Sbjct: 461 LSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLET-QSSLA 519

Query: 271 PEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAA----------------AAPAAASPP 314
           P +++      TT      P+ A PP  TA+ P                  A P+  + P
Sbjct: 520 PPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTP 579

Query: 315 PPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLP-- 372
           PP+ P        Q P            P + G+   P+   +  PP    P   L P  
Sbjct: 580 PPETPSSIATPPPQAPPALA-------SPPLQGLPSPPL-SPLATPPPQAPPXLALPPLQ 631

Query: 373 TPPFPPMAQPVI------------------------PPTPPVQQPFQASFQAQNEPLTQK 408
            PP PP + P+                         PP+PPVQ PF         P    
Sbjct: 632 APPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATP 691

Query: 409 PHQQEMEVEQPCIQ 422
           P Q    +  P +Q
Sbjct: 692 PSQAPPSLAAPPLQ 705



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 76/316 (24%), Positives = 103/316 (32%), Gaps = 66/316 (20%)

Query: 156 PPPVKVSSEP---------------PTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQ 200
           PPP++ +S P               P QA P+ +   P    S       Q         
Sbjct: 543 PPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPP 602

Query: 201 LQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSE---QKAAFPPPEQKTAF 257
           LQ +      P  P SP       A        L+  P+ P+       A P P+   A 
Sbjct: 603 LQGL------PSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNAL 656

Query: 258 DKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASP---- 313
              LL    +   P    ++           +P A+ P +P+AT P+ A P+ A+P    
Sbjct: 657 AVHLLQA-PFSPPPSPPVQAP---------FSPPASPPVSPSATPPSQAPPSLAAPPLQV 706

Query: 314 ---------------PPPQAPFGFPGDGMQ----QPAYTQHQNMDQFQPRMMGIQQDPMH 354
                          PPPQAP       +Q     PA           PR+  +   P  
Sbjct: 707 PPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAP-P 765

Query: 355 HQVPLPPNGQMPGFGLLPTPPFPPMAQPVIP----PTPPV----QQPFQASFQAQNEPLT 406
            QVP  P   +P   L   PP  P A    P    P+PP     Q PF  S      PL 
Sbjct: 766 LQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLA 825

Query: 407 QKPHQQEMEVEQPCIQ 422
             P Q    +  P +Q
Sbjct: 826 TPPPQAPPVLAAPLLQ 841



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 91/370 (24%), Positives = 108/370 (29%), Gaps = 108/370 (29%)

Query: 694 ALQPPAFTPPLGIPPPGFGPGVPPPPPP--PPFLR-----------------PGFNPMHL 734
           A  P A  P L  P P   PG P PPPP  P  LR                  G     +
Sbjct: 14  ARTPAARAPGLLTPRP---PGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATI 70

Query: 735 PPGFLPPGPP---------PPITPPVS-----IPPPHTP---PISIPNLVSG-------- 769
           P      GP          P   PP S      PP       P+S P   SG        
Sbjct: 71  PESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLG 130

Query: 770 ------------ARGNAESGD--SVKMYGSAVPPAAPT-NLPTPPVTQPVSLLGTQGVAP 814
                       ARG A      S    G+    + PT   P+P + +     GT+   P
Sbjct: 131 QKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLP 190

Query: 815 GPVIG------LQAPSTGLLGA------RPGLIPLQRPP---GMPPPHLQRF-----PLM 854
            P          + P   +  A       P     +RP    G+  P  +       PL 
Sbjct: 191 RPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLS 250

Query: 855 PPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGG------PGPG 908
            P    P    RG P  P   + P P G++   PP     R    P LG         P 
Sbjct: 251 SPARSGPSA--RGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPS 308

Query: 909 PGGPEDRD-----------GRQQPPQQPQQQPQPQAPQQPQQQQQQQ-------PPPSQQ 950
           P G + R                PP  P   P P AP  P      Q        PPSQ 
Sbjct: 309 PSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQA 368

Query: 951 PPPTQQQPQQ 960
           PP     P Q
Sbjct: 369 PPSMTTPPMQ 378



 Score = 43.9 bits (102), Expect = 9e-04
 Identities = 65/292 (22%), Positives = 86/292 (29%), Gaps = 49/292 (16%)

Query: 130 PLLDMAAGTSNAAPVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAV 189
           P L +      + P++ + T    +PPP     + PP Q  P+   + P  PS+     V
Sbjct: 702 PPLQVPPSPPASPPMSPSATPPPQAPPP----LAAPPLQVPPSPPASPPMSPSATPPPRV 757

Query: 190 AQLFQTTQGQQLQQILQTFQQPPK--PQSPALDNAVMAQVQAITAQLKTTPTQPSE---- 243
             L            LQ    PP   P SP       A     T  L+  P+ P+     
Sbjct: 758 PPLLAAPP-------LQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQ 810

Query: 244 -----------QKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAA 292
                         A PPP+        LL        P A          + T  AP  
Sbjct: 811 APFSPSASLPMSPLATPPPQAPPVLAAPLLQ---VPPSPPA----------SPTLQAPRR 857

Query: 293 AVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQP-RMMGIQQD 351
              P P  +V       A +P PP  P   P   +  P    H +     P  + G    
Sbjct: 858 PPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSG 917

Query: 352 PMHHQVPLPPNG------QMPGFGLLPTPPFPPMAQPVIP-PTPPVQQPFQA 396
           P       PP            +   P PP      P  P P PP   P  A
Sbjct: 918 PEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSA 969



 Score = 36.6 bits (83), Expect = 0.14
 Identities = 67/297 (22%), Positives = 100/297 (33%), Gaps = 31/297 (10%)

Query: 135 AAGTSNAAPVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQLP--------SSDAF 186
           +AGTS+  P +    +  G   PP K +S  P  +   +       P        S++  
Sbjct: 82  SAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEET 141

Query: 187 AAVAQLFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQL-----KTTPTQP 241
            A  +  +  +   L    +     P P +P+   A  ++       L        P  P
Sbjct: 142 VARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPP 201

Query: 242 SE--QKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPT 299
           +E  +K+     E  T        R            S+   ++A   ++PA + P A  
Sbjct: 202 TEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSA-R 260

Query: 300 ATVPAAAAPAAASPPPPQA---PFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQ 356
            T  A A P+   P   QA   P   P      PA     +     P   G +  P    
Sbjct: 261 GTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARP---- 316

Query: 357 VPLPPNGQMPGFGLLPT--PPFPPMAQ--PVIPPTPPVQQPFQASFQAQNEPLTQKP 409
           VP P N   P    LP   PP PP+A   P+ PP+P      Q        P +Q P
Sbjct: 317 VPPPDNAATP----LPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAP 369



 Score = 35.4 bits (80), Expect = 0.31
 Identities = 58/285 (20%), Positives = 93/285 (32%), Gaps = 69/285 (24%)

Query: 135 AAGTSNAAPVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQ 194
           +AG     P + +++++      P +  S P  + TP + PA P  P      A+     
Sbjct: 229 SAGGGLQRPASRSLSSSATPLSSPAR--SGPSARGTPRA-PAHPSQPKPKGLQAL----- 280

Query: 195 TTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQK 254
                          +PP+   P  D A    +  +++    TP+    +    PPP+  
Sbjct: 281 ---------------RPPQVTPPRKDAA--PALGPLSSSPLATPSPSGTKARPVPPPDNA 323

Query: 255 TAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPP 314
                           P  +  S    T       P    PP+P+A       P+  + P
Sbjct: 324 AT------------PLPATLPPSPPLAT-------PLPLAPPSPSAPPSLQTLPSPPATP 364

Query: 315 PPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTP 374
           P QAP       MQ P            P +  I    + H +  P          L  P
Sbjct: 365 PSQAPPSMTTPPMQAP------------PSLQTIPPIQVPHSLTSPS---------LQAP 403

Query: 375 PFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEMEVEQP 419
           P  P+A   +  T  +  P   + QA +  LT  P Q +  +  P
Sbjct: 404 P-SPLALSSLQATTSLGSP---TLQATHSFLTMSPRQTQASLTSP 444


>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
          Length = 416

 Score =  114 bits (286), Expect = 4e-25
 Identities = 122/376 (32%), Positives = 139/376 (36%), Gaps = 72/376 (19%)

Query: 634 PKKPENEVAQNG----GAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPP-------PQV 682
           P KP+    Q G    G      +P  P P+    P  P P   P   PP       P+ 
Sbjct: 54  PGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRS 113

Query: 683 PPHQP-GPPVVGALQPPAFTPPLGIP--PPGFGPGVP--PPPP-----PPP--------F 724
           PP +P GPP  G  QP    PP G P  PP  G   P  PPPP     PPP         
Sbjct: 114 PPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSS 173

Query: 725 LRPGFNPMHLPP--GFLPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKM 782
             P   P   PP  G  P GPPPP   P   PP        P      +G    GD+ K 
Sbjct: 174 RSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDN-KS 232

Query: 783 YGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPG 842
             +  PP  P   P     QP      QG  P P      P  G            +P G
Sbjct: 233 QSARSPPGKPQGPPPQGGNQP------QGPPPPPGKPQGPPPQGG----------NKPQG 276

Query: 843 MPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGL 902
            PPP   + P  PP+        R PP  P G   PPP G   P  P  P  +P G P  
Sbjct: 277 PPPPGKPQGP--PPQGGSKSRSSRSPPGKPQG---PPPQGGNQPQGPPPPPGKPQGPPPQ 331

Query: 903 GG------PGPG-PGGPEDRDG-----RQQPPQQPQQQPQ-----PQAPQQPQ--QQQQQ 943
           GG      P PG P GP  + G      + PP +PQ  PQ     PQ P  P     QQ 
Sbjct: 332 GGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQP 391

Query: 944 QPPPSQQPPPTQQQPQ 959
           Q PP+ QP    + PQ
Sbjct: 392 QAPPAGQPQGPPRPPQ 407



 Score =  109 bits (272), Expect = 2e-23
 Identities = 120/350 (34%), Positives = 131/350 (37%), Gaps = 50/350 (14%)

Query: 642 AQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFT 701
           AQN   + S  E  S I    P   PP     P    PP  P    GPP  G  QP    
Sbjct: 16  AQNLNEDVSQEESPSLIAGN-PQGAPPQGGNKP--QGPPSPPGKPQGPPPQGGNQPQGPP 72

Query: 702 PPLGIP---PPGFG--PGVPPPP-----PPP-------PFLRPGFNPMHLPP--GFLPPG 742
           PP G P   PP  G  P  PPPP     PPP       P   PG  P   PP  G  P G
Sbjct: 73  PPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPG-KPQGPPPQGGNQPQG 131

Query: 743 PPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQ 802
           PPPP   P   PP        P      +G    GD+ K   S  PP  P   P     Q
Sbjct: 132 PPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDN-KSRSSRSPPGKPQGPPPQGGNQ 190

Query: 803 PVSLLGTQGVAPGPVIGLQAPSTGLLGARP-GLIPLQRPPGMPPP-----HLQRFPLMPP 856
           P      QG  P P      P  G  G +P G  P  +P G PP         R P   P
Sbjct: 191 P------QGPPPPPGKPQGPPPQG--GNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKP 242

Query: 857 RPMPPH--MMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGG--------PG 906
           +  PP      +GPPP PG    PPP G   P  P  P  +P G P  GG        P 
Sbjct: 243 QGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPP-GKPQGPPPQGGSKSRSSRSPP 301

Query: 907 PGPGGPEDRDGRQ-QPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQ 955
             P GP  + G Q Q P  P  +PQ   PQ   + Q   PP   Q PP Q
Sbjct: 302 GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQ 351



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 97/291 (33%), Positives = 106/291 (36%), Gaps = 62/291 (21%)

Query: 680 PQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHLPP--G 737
           PQ  P Q G    G   PP    P G PP G   G  P  PPPP   PG  P   PP  G
Sbjct: 36  PQGAPPQGGNKPQGPPSPPG--KPQGPPPQG---GNQPQGPPPP---PG-KPQGPPPQGG 86

Query: 738 FLPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPT 797
             P GPPPP  P    PPP                    GD  +   S  PP  P   P 
Sbjct: 87  NKPQGPPPPGKPQG--PPPQ-------------------GDKSRSPRS--PPGKPQGPPP 123

Query: 798 PPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARP-GLIPLQRPPGMPPP-----HLQRF 851
               QP      QG  P P      P  G  G +P G  P  +P G PP         R 
Sbjct: 124 QGGNQP------QGPPPPPGKPQGPPPQG--GNKPQGPPPPGKPQGPPPQGDNKSRSSRS 175

Query: 852 PLMPPRPMPPH--MMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGP-GPG 908
           P   P+  PP      +GPPP PG    PPP G            +P G P  G P GP 
Sbjct: 176 PPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGN----------KPQGPPPPGKPQGPP 225

Query: 909 PGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQPQ 959
           P G       + PP +PQ  P PQ   QPQ        P   PP    +PQ
Sbjct: 226 PQGDNKSQSARSPPGKPQGPP-PQGGNQPQGPPPPPGKPQGPPPQGGNKPQ 275



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 72/220 (32%), Positives = 86/220 (39%), Gaps = 30/220 (13%)

Query: 764 PNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAP 823
           P+L++G    A      K  G   PP  P   P     QP      QG  P P      P
Sbjct: 29  PSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGPPPQGGNQP------QGPPPPPGKPQGPP 82

Query: 824 STGLLGARP-GLIPLQRPPGMPPP-HLQRFPLMPP-RPMPPHMMHRGPPPGPGGFAMPPP 880
             G  G +P G  P  +P G PP     R P  PP +P  P       P GP     PPP
Sbjct: 83  PQG--GNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPP----PPP 136

Query: 881 HGMKGPFPPHGPFVRPGGMPGLGGP-GPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQ- 938
              +GP P  G   +P G P  G P GP P G       + PP +PQ  P PQ   QPQ 
Sbjct: 137 GKPQGPPPQGGN--KPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPP-PQGGNQPQG 193

Query: 939 ----QQQQQQPP------PSQQPPPTQQQPQQFRNDNRQQ 968
                 + Q PP      P   PPP + Q    + DN+ Q
Sbjct: 194 PPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQ 233



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 55/163 (33%), Positives = 66/163 (40%), Gaps = 31/163 (19%)

Query: 821 QAPSTGLLGARPGLIPLQ---RPPGMPPPHLQRFPLMPPRPMPPH-MMHRGPPPGPGGFA 876
           Q  S  L+   P   P Q   +P G P P     P  P  P P      +GPPP PG   
Sbjct: 25  QEESPSLIAGNPQGAPPQGGNKPQGPPSP-----PGKPQGPPPQGGNQPQGPPPPPGKPQ 79

Query: 877 MPPPHGMKGPFPPHGPFVRPGGMPGLGGP-GPGPGGPEDRDGRQQPPQQPQQQP-----Q 930
            PPP G            +P G P  G P GP P G + R  R  PP +PQ  P     Q
Sbjct: 80  GPPPQGGN----------KPQGPPPPGKPQGPPPQGDKSRSPRS-PPGKPQGPPPQGGNQ 128

Query: 931 PQAPQQPQQQQQQQPP-----PSQQPPPTQQQPQQFRNDNRQQ 968
           PQ P  P  + Q  PP     P   PPP + Q    + DN+ +
Sbjct: 129 PQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSR 171



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 61/263 (23%), Positives = 73/263 (27%), Gaps = 55/263 (20%)

Query: 143 PVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQ 202
           P  +     +G PPPP K    PP        P  P  P               QG    
Sbjct: 183 PPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPP----------PQGDNKS 232

Query: 203 QILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLL 262
           Q  ++   P KPQ P        Q           P      K   PPP  K        
Sbjct: 233 QSARS--PPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQ------ 284

Query: 263 DRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGF 322
                   P+   +S+            + + P  P    P         PPPP  P G 
Sbjct: 285 -----GPPPQGGSKSRS-----------SRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGP 328

Query: 323 PGDGMQQPAYTQHQNMDQFQPRMMGI----------------QQDPMHHQVPLPPNGQMP 366
           P  G  +P         Q  P   G                 QQ+  + Q P PP G  P
Sbjct: 329 PPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPPPAGGNP 388

Query: 367 GFGLLPTPPFPPMAQPVIPPTPP 389
                  P  PP  QP  PP PP
Sbjct: 389 -----QQPQAPPAGQPQGPPRPP 406



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 57/251 (22%), Positives = 70/251 (27%), Gaps = 35/251 (13%)

Query: 143 PVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQ 202
           P  +     +G PPPP K    PP        P  P  P               QG    
Sbjct: 121 PPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPP----------PQGDNKS 170

Query: 203 QILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLL 262
           +  ++   P KPQ P        Q           P      K   PPP  K        
Sbjct: 171 RSSRS--PPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKP------- 221

Query: 263 DRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGF 322
                   P    ++K +          A + P  P    P         PPPP  P G 
Sbjct: 222 ------QGPPPQGDNKSQS---------ARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGP 266

Query: 323 PGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQP 382
           P  G  +P         Q  P   G  +       P  P G  P  G  P  P PP  +P
Sbjct: 267 PPQGGNKPQGPPPPGKPQGPPPQGG-SKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKP 325

Query: 383 VIPPTPPVQQP 393
             PP     +P
Sbjct: 326 QGPPPQGGNKP 336



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 61/263 (23%), Positives = 78/263 (29%), Gaps = 22/263 (8%)

Query: 134 MAAGTSNAAPVAENVTNNEGSPPPPVKVSSEPPTQAT-PNSVPAVPQLPSSDAFAAVAQL 192
           + AG    AP  +     +G P PP K    PP     P   P  P  P         Q 
Sbjct: 31  LIAGNPQGAP-PQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPP----PQG 85

Query: 193 FQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPE 252
               QG            P KPQ P          ++   + +  P Q   Q    PPP 
Sbjct: 86  GNKPQGP---------PPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPP 136

Query: 253 QKTAFDKKLLDRFDYDDEPEAVEES--KKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAA 310
            K                P    +    + D  + ++ +P    P  P    P       
Sbjct: 137 GKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSP----PGKPQGPPPQGGNQPQ 192

Query: 311 ASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGL 370
             PPPP  P G P  G  +P         Q  P   G  +       P  P G  P  G 
Sbjct: 193 GPPPPPGKPQGPPPQGGNKPQGPPPPGKPQ-GPPPQGDNKSQSARSPPGKPQGPPPQGGN 251

Query: 371 LPTPPFPPMAQPVIPPTPPVQQP 393
            P  P PP  +P  PP     +P
Sbjct: 252 QPQGPPPPPGKPQGPPPQGGNKP 274



 Score = 38.5 bits (88), Expect = 0.036
 Identities = 39/159 (24%), Positives = 49/159 (30%), Gaps = 22/159 (13%)

Query: 295 PPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMH 354
           P  P    P         PPPP  P G P  G  +P         Q  P      + P  
Sbjct: 54  PGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSP-- 111

Query: 355 HQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEM 414
              P  P G  P  G  P  P PP  +P  PP        Q   + Q  P   KP     
Sbjct: 112 RSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPP-------QGGNKPQGPPPPGKPQGPPP 164

Query: 415 EVEQPCIQEVKRHMSDNRKSRSRSASRSPKRRRSRSGSR 453
           +              DN+   SRS    P+    + G++
Sbjct: 165 Q-------------GDNKSRSSRSPPGKPQGPPPQGGNQ 190


>gi|4826998 splicing factor proline/glutamine rich (polypyrimidine
           tract binding protein associated) [Homo sapiens]
          Length = 707

 Score =  107 bits (268), Expect = 5e-23
 Identities = 92/271 (33%), Positives = 107/271 (39%), Gaps = 39/271 (14%)

Query: 689 PPVVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGPPPPIT 748
           PP +G  Q      P+G  P   GP  P PPPPP   +    P   PP   PP  PPP  
Sbjct: 35  PPGMGLNQNRG---PMGPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQPPPHP 91

Query: 749 PP-VSIPPPHTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLL 807
            P     PP  P  S   +V+   G A    S     S+ PPA P     PP        
Sbjct: 92  QPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPP-------- 143

Query: 808 GTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPR----PMPPHM 863
              G  PGP      P   +  A PG  P       P P     P  PP+    P PP  
Sbjct: 144 ---GSGPGPT---PTPPPAVTSAPPGAPP-------PTPPSSGVPTTPPQAGGPPPPPAA 190

Query: 864 MHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGPG-----PGPGGPEDRDGR 918
           +   P PGPG    P P G KG   P GP  +PGG PGL  PG     P  GG E R GR
Sbjct: 191 V---PGPGPGPKQGPGPGGPKGGKMPGGP--KPGGGPGLSTPGGHPKPPHRGGGEPRGGR 245

Query: 919 QQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQ 949
           Q  P   QQ  Q   P  P  + +++   S+
Sbjct: 246 QHHPPYHQQHHQGPPPGGPGGRSEEKISDSE 276



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 76/244 (31%), Positives = 89/244 (36%), Gaps = 26/244 (10%)

Query: 638 ENEVAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQP 697
           +N      G   S  +P  P P P      P P   P   PPP  PP  P P       P
Sbjct: 42  QNRGPMGPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQPPPHPQPHQQQQPPP 101

Query: 698 PA--FTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPP 755
           P    + P+    PG  PGV   PP      P   P    P    PGP P   P V+  P
Sbjct: 102 PPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAP 161

Query: 756 PHTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPG 815
           P  PP + P+          SG       +  PP  P  +P P           QG  PG
Sbjct: 162 PGAPPPTPPS----------SGVPTTPPQAGGPPPPPAAVPGPGPGP------KQGPGPG 205

Query: 816 PVIGLQAPSTGLLGARPGLIPLQRPPGMP-PPHL-QRFPLMPPRPMPPH--MMHRGPPP- 870
              G + P     G  PG   L  P G P PPH     P    +  PP+    H+GPPP 
Sbjct: 206 GPKGGKMPGGPKPGGGPG---LSTPGGHPKPPHRGGGEPRGGRQHHPPYHQQHHQGPPPG 262

Query: 871 GPGG 874
           GPGG
Sbjct: 263 GPGG 266



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 38/118 (32%), Positives = 46/118 (38%), Gaps = 6/118 (5%)

Query: 836 PLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVR 895
           P  +PP  P PH Q+ P  PP+     ++ +GP P PG  + PP      P  P      
Sbjct: 83  PPHQPPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATP-----P 137

Query: 896 PGGMPGLGGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQPPP 953
             G P   GPGP P  P        P   P   P    P  P Q     PPP+  P P
Sbjct: 138 TSGAPPGSGPGPTP-TPPPAVTSAPPGAPPPTPPSSGVPTTPPQAGGPPPPPAAVPGP 194



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 44/99 (44%), Positives = 46/99 (46%), Gaps = 14/99 (14%)

Query: 866 RGPPPGPGG---FAMPPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQPP 922
           RG   G GG   F  PPP GM G     GP    G  PG  GP P    P     +QQPP
Sbjct: 19  RGGGGGRGGLHDFRSPPP-GM-GLNQNRGPM---GPGPGQSGPKPPIPPPPPHQQQQQPP 73

Query: 923 QQ---PQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQP 958
            Q   PQQ P  Q P  PQ  QQQQPPP   PP    +P
Sbjct: 74  PQQPPPQQPPPHQPPPHPQPHQQQQPPP---PPQDSSKP 109



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 35/87 (40%), Positives = 40/87 (45%), Gaps = 12/87 (13%)

Query: 891 GPFVRPGGMPGLGG------PGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQ 944
           G F R GG  G GG      P PG G  ++R      P   Q  P+P  P  P  QQQQQ
Sbjct: 14  GGFHRRGGGGGRGGLHDFRSPPPGMGLNQNRG--PMGPGPGQSGPKPPIPPPPPHQQQQQ 71

Query: 945 PPPS----QQPPPTQQQPQQFRNDNRQ 967
           PPP     QQPPP Q  P    +  +Q
Sbjct: 72  PPPQQPPPQQPPPHQPPPHPQPHQQQQ 98



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 62/258 (24%), Positives = 79/258 (30%), Gaps = 62/258 (24%)

Query: 155 PPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPKP 214
           PPPP +   +PP Q  P   P   Q P                     Q  Q  Q PP P
Sbjct: 62  PPPPHQQQQQPPPQQPPPQQPPPHQPPPHP------------------QPHQQQQPPPPP 103

Query: 215 QSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEAV 274
           Q  +    V+AQ       + + P   S    A PP                    P   
Sbjct: 104 QDSS--KPVVAQGPGPAPGVGSAPPASSSAPPATPPTS----------------GAPPGS 145

Query: 275 EESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQ 334
                       T+AP  A PP P ++      P A  PPPP A    PG G +Q     
Sbjct: 146 GPGPTPTPPPAVTSAPPGAPPPTPPSSGVPTTPPQAGGPPPPPAAVPGPGPGPKQ----- 200

Query: 335 HQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPF 394
                   P   G +   M       P G  PG G       P ++ P   P PP +   
Sbjct: 201 -------GPGPGGPKGGKM-------PGGPKPGGG-------PGLSTPGGHPKPPHRGGG 239

Query: 395 QASFQAQNEPLTQKPHQQ 412
           +     Q+ P   + H Q
Sbjct: 240 EPRGGRQHHPPYHQQHHQ 257



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 49/154 (31%), Positives = 54/154 (35%), Gaps = 20/154 (12%)

Query: 637 PENEVAQNGGAETSHTEPVS-PIPKPLPVPV-----PPIPVPAPITVPPPQVPPHQPGPP 690
           P +  A      TS   P S P P P P P      P  P P P +   P  PP   GPP
Sbjct: 126 PASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPTTPPQAGGPP 185

Query: 691 VVGALQP-----PAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHLPP---GFLPPG 742
              A  P     P   P  G P  G  PG P P   P    PG +P   PP   G  P G
Sbjct: 186 PPPAAVPGPGPGPKQGPGPGGPKGGKMPGGPKPGGGPGLSTPGGHPK--PPHRGGGEPRG 243

Query: 743 ----PPPPITPPVSIPPPHTPPISIPNLVSGARG 772
                PP        PPP  P       +S + G
Sbjct: 244 GRQHHPPYHQQHHQGPPPGGPGGRSEEKISDSEG 277



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 30/112 (26%), Positives = 34/112 (30%), Gaps = 24/112 (21%)

Query: 288 TAPAAAVPPAPT---ATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPR 344
           + P   +PP P       P    P    PPP Q P          P    HQ      P 
Sbjct: 54  SGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQPP----------PHPQPHQQQQPPPP- 102

Query: 345 MMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPT---PPVQQP 393
                  P     P+   G  P  G+   PP    A P  PPT   PP   P
Sbjct: 103 -------PQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGP 147



 Score = 32.0 bits (71), Expect = 3.4
 Identities = 23/77 (29%), Positives = 29/77 (37%), Gaps = 8/77 (10%)

Query: 343 PRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQN 402
           P  MG+ Q+    + P+ P     G    P PP PP         PP QQP         
Sbjct: 35  PPGMGLNQN----RGPMGPGPGQSG----PKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQ 86

Query: 403 EPLTQKPHQQEMEVEQP 419
            P   +PHQQ+     P
Sbjct: 87  PPPHPQPHQQQQPPPPP 103



 Score = 31.6 bits (70), Expect = 4.4
 Identities = 27/75 (36%), Positives = 31/75 (41%), Gaps = 14/75 (18%)

Query: 355 HQVPLPPNGQMPGFGLL----PTPPFPPMA--QPVIPPTPPVQQ----PFQASFQAQNEP 404
           H    PP    PG GL     P  P P  +  +P IPP PP QQ    P Q     Q  P
Sbjct: 29  HDFRSPP----PGMGLNQNRGPMGPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPP 84

Query: 405 LTQKPHQQEMEVEQP 419
               PH Q  + +QP
Sbjct: 85  HQPPPHPQPHQQQQP 99



 Score = 31.2 bits (69), Expect = 5.8
 Identities = 36/161 (22%), Positives = 62/161 (38%), Gaps = 28/161 (17%)

Query: 929  PQPQAPQQPQQQQQQQPPPSQQPPPTQQQPQQFRNDNRQQFNSGRDQERFGRRSFGNRVE 988
            P+  A + P  Q++++ PP      T      F  +  Q++ S  + E+  R      ++
Sbjct: 460  PEKLAQKNPMYQKERETPPRFAQHGT------FEYEYSQRWKSLDEMEKQQREQVEKNMK 513

Query: 989  NDRERYGNRNDD---RDNSNRDRREWGRRSPDRDRHRDL----------------EERNR 1029
            + +++  +  +D      +N  R++  RR  +  R  +L                EER R
Sbjct: 514  DAKDKLESEMEDAYHEHQANLLRQDLMRRQEELRRMEELHNQEMQKRKEMQLRQEEERRR 573

Query: 1030 RSSGH--RDRERDSRDRESRREKEEARGKEKPEVTD-RAGG 1067
            R      R RE + + R  R E     G   P   D R GG
Sbjct: 574  REEEMMIRQREMEEQMRRQREESYSRMGYMDPRERDMRMGG 614


>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
            sapiens]
          Length = 1362

 Score =  104 bits (259), Expect = 5e-22
 Identities = 151/656 (23%), Positives = 234/656 (35%), Gaps = 145/656 (22%)

Query: 372  PTPPFPPMAQPVIPP-----TPPVQQPFQASFQAQNEPLTQKPHQQ------EMEVEQPC 420
            P  P   ++ P +PP      PP      +   + ++  T    ++      E++ +   
Sbjct: 461  PEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKA 520

Query: 421  IQEVKRHMSDNRKSRSRSASRSPKRRRSRSGSRSRR-SRHRRSRSRSRDRRRHSPRSRSQ 479
            + E    +S  ++++ +   +  K ++     R      +++S+++    ++    + S 
Sbjct: 521  VHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSN 580

Query: 480  ERRDREKERERRQKGLPQVKPETASVCSTTLWVGQLDKRTTQQDVASLLEEFGPIESINM 539
                +++    + K  P  + E    C    +    +KR    D             IN 
Sbjct: 581  SNVSKKEPAPMKSKPPPTYESEEEDKCKPMSYE---EKRQLSLD-------------INK 624

Query: 540  IPPRGCAYIVMVHRQDAYRALQKLSRGNYKVNQKSIK----------IAWALNKGIKADY 589
            +P      +V +  Q    +L+  +    +++ +++K          +   L K  K   
Sbjct: 625  LPGEKLGRVVHII-QSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQA 683

Query: 590  KQYWDVELGVTYIPWDKVKPEELESFCEGGMLDSDTLNPDWKGIPKKPENEVAQNGGAET 649
            ++  DV  G + +        E ES  E    DS+    +     KK  +   +      
Sbjct: 684  EKV-DVIAGSSKMKG--FSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHH 740

Query: 650  SHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPP 709
             H + +   P P+P   PP          PPQ PP  P PP     QPP   PP  +P  
Sbjct: 741  HHHQQMQQAPAPVPQQPPP----------PPQQPP--PPPPPQQQQQPPPPPPPPSMPQQ 788

Query: 710  GFGPGVPPPPPP-----PPFLRPG-----FNP--------MHLPPGFLPPGPPPPITPPV 751
               P +   PPP      P L P      F+P        +HLP   LPP  P P   P 
Sbjct: 789  A-APAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQP---PE 844

Query: 752  SIPPPH-------TPPI---SIPNLVSGARGNAESGDSVKMYGSAVPPAAPTN--LPTPP 799
               PPH       +PP    ++P   S     A +         AV PA      LP PP
Sbjct: 845  HSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPP 904

Query: 800  VTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPM 859
            + QP  +L      P P      P T +       + LQ+        LQ+  + PP P+
Sbjct: 905  MAQPPQVLLEDEEPPAP------PLTSMQMQ----LYLQQ--------LQK--VQPPTPL 944

Query: 860  PPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQ 919
             P +  +  PP P    +PPP        PH     P     L    P P  P+      
Sbjct: 945  LPSVKVQSQPPPP----LPPP--------PH-----PSVQQQLQQQPPPPPPPQP----- 982

Query: 920  QPPQQPQQQPQP--------------QAPQQPQQQQQQQPPPSQQPPPTQ-QQPQQ 960
            QPP Q Q QP P              Q P  PQ QQ   PPP QQPPP Q  +PQQ
Sbjct: 983  QPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPPHPPPGQQPPPPQPAKPQQ 1038



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 95/403 (23%), Positives = 151/403 (37%), Gaps = 66/403 (16%)

Query: 661  PLPVPVPPIP-VPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPP 719
            P P+P PP P V   +   PP  PP QP PP     QPP    P+ + P  F   +  PP
Sbjct: 955  PPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPP--RPVHLQPMQFSTHIQQPP 1012

Query: 720  PPPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDS 779
            PP      G  P H PPG  PP PP P  P   I   H+P           R +     S
Sbjct: 1013 PPQ-----GQQPPHPPPGQQPP-PPQPAKPQQVIQHHHSP-----------RHHKSDPYS 1055

Query: 780  VKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGA---RPGLIP 836
                G      +P  + +P ++Q  SL         P   +Q     L  A   +P  + 
Sbjct: 1056 T---GHLREAPSPLMIHSPQMSQFQSLTHQSP----PQQNVQPKKQELRAASVVQPQPLV 1108

Query: 837  LQRPPGMPPPHLQRFPLMPP-RPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVR 895
            + +   +  P ++  P  P  RP PP    + P        +P    MK P     P +R
Sbjct: 1109 VVKEEKIHSPIIRSEPFSPSLRPEPP----KHPESIKAPVHLPQRPEMK-PVDVGRPVIR 1163

Query: 896  PGGMPGLGGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPS-----QQ 950
            P   P    P PG             P + +Q+ +P+ P  P++  + +   S     Q+
Sbjct: 1164 P---PEQNAPPPGA------------PDKDKQKQEPKTPVAPKKDLKIKNMGSWASLVQK 1208

Query: 951  PPPTQQQPQQFRNDNRQQFNSGRDQERFGRRSFGNRVENDRERYGNRNDDRDNSNRDRRE 1010
             P T     +  +D+ +QF          RR+   + E ++              R R+E
Sbjct: 1209 HPTTPSSTAKSSSDSFEQF----------RRAAREKEEREKALKAQAEHAEKEKERLRQE 1258

Query: 1011 WGRRSPDRDRHRDLEERNRRSSGHRDRERDSRDRESRREKEEA 1053
              R   D D        +  +   +++++  R  + ++++++A
Sbjct: 1259 RMRSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQA 1301



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 71/282 (25%), Positives = 98/282 (34%), Gaps = 54/282 (19%)

Query: 155  PPPPVKVSSEPPTQATPNSVP---------------------AVPQLPSSDAFAAVAQLF 193
            PPPP +   +PP    P S+P                       PQLP S  F  +    
Sbjct: 766  PPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGS-VFDPIGHFT 824

Query: 194  QTTQGQQLQQILQTFQQPPKPQSPA-LDNAVMAQVQAITAQLKTTPTQPSEQKAAFPP-P 251
            Q        ++     QPP+  +P  L+   +    A+   L   P++PS + AA PP P
Sbjct: 825  QPILHLPQPELPPHLPQPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKP 884

Query: 252  EQKTAF-----DKKLLDRFDYDDEPEAVEESKKEDTTAVTT------TAPAAAVPPAPTA 300
             +  A         LL +      P+ + E ++     +T+            V P PT 
Sbjct: 885  ARPPAVSPALTQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQP-PTP 943

Query: 301  TVPAAAAPAAASPPPPQAPFGFPGDGMQQ------PAYTQHQNMDQFQPRMMGIQQDPM- 353
             +P+    +   PP P  P       +QQ      P   Q     Q QP    +   PM 
Sbjct: 944  LLPSVKVQSQPPPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQ 1003

Query: 354  ---HHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQ 392
               H Q P PP GQ         PP PP  Q   PP P   Q
Sbjct: 1004 FSTHIQQPPPPQGQQ--------PPHPPPGQQPPPPQPAKPQ 1037



 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 53/200 (26%), Positives = 66/200 (33%), Gaps = 43/200 (21%)

Query: 619 GMLDSDTLNPDWKGIPKKPENEVAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPI-TV 677
           G  ++ T  P    +P   +            +  PV   P P P   P + V  P+ TV
Sbjct: 182 GRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTV 241

Query: 678 PPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPG 737
            PPQ                     PL  PPP     VPP P PPP   P   P+   P 
Sbjct: 242 VPPQ---------------------PLQTPPP-----VPPQPQPPP--APAPQPVQSHPP 273

Query: 738 FLPPGPPP-----------PITPPVSIPPPHTPPISIPNLVSGARG-NAESGDSVKMYGS 785
            +   P P             T P +I P H PP   P   +   G   ES   VK    
Sbjct: 274 IIAATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKK 333

Query: 786 AVPPAAPTNLPTPPVTQPVS 805
            VP +     P P  +  VS
Sbjct: 334 DVPDS--QQHPAPEKSSKVS 351



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 93/452 (20%), Positives = 152/452 (33%), Gaps = 123/452 (27%)

Query: 144  VAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQQ 203
            V+  +T     P PP+   ++PP     +  P  P L S      + QL +      L  
Sbjct: 890  VSPALTQTPLLPQPPM---AQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLP 946

Query: 204  ILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLD 263
             ++   QPP P  P    +V  Q+Q    Q    P  P  Q    PPP+Q+         
Sbjct: 947  SVKVQSQPPPPLPPPPHPSVQQQLQ----QQPPPPPPPQPQ----PPPQQQ--------- 989

Query: 264  RFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFP 323
               +   P  V     + +T +         PP P    P    P    PPP  A    P
Sbjct: 990  ---HQPPPRPVHLQPMQFSTHIQQ-------PPPPQGQQPPHPPPGQQPPPPQPAK---P 1036

Query: 324  GDGMQQPAYTQHQNMDQF---------------QPRMMGIQQDPMHHQVPLPPNGQMPGF 368
               +Q     +H   D +                P+M   Q   + HQ P   N Q    
Sbjct: 1037 QQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQS--LTHQSPPQQNVQPKKQ 1094

Query: 369  GL-----------------------LPTPPFPPMAQPVIPPTP-----PVQQPFQASFQA 400
             L                       + + PF P  +P  P  P     PV  P +   + 
Sbjct: 1095 ELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESIKAPVHLPQRPEMKP 1154

Query: 401  QN--EPLTQKPHQ------------QEMEVEQPCIQE--------------VKRH----- 427
             +   P+ + P Q            Q+ E + P   +              V++H     
Sbjct: 1155 VDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMGSWASLVQKHPTTPS 1214

Query: 428  -----MSDNRKSRSRSASRSPKRRRSRSG----SRSRRSRHRRSRSRSR---DRRRHSPR 475
                  SD+ +   R+A    +R ++       +   + R R+ R RSR   D    + R
Sbjct: 1215 STAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERMRSREDEDALEQARR 1274

Query: 476  SRSQERRDREKERERRQKGLPQVKPETASVCS 507
            +  + RR +E+++++RQ+   Q + + A+V +
Sbjct: 1275 AHEEARRRQEQQQQQRQEQQQQQQQQAAAVAA 1306



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 61/212 (28%), Positives = 78/212 (36%), Gaps = 42/212 (19%)

Query: 755 PPHTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAP 814
           P     I I       RG  E+G + K   S VP    T   TPP TQ      T    P
Sbjct: 165 PTEETEIMIVQAKGRGRGRKETG-TAKPGVSTVPNT--TQASTPPQTQ------TPQPNP 215

Query: 815 GPVIGLQAPSTGLLGARPGLIPLQRP--PGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGP 872
            PV   QA         P LI +Q P    +PP  LQ  P +PP+P PP      P P P
Sbjct: 216 PPV---QATPHPFPAVTPDLI-VQTPVMTVVPPQPLQTPPPVPPQPQPP------PAPAP 265

Query: 873 GGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGPG----PGPGGPEDRDGRQQPPQQPQQQ 928
                        P   H P +     P     G         P   D   +PP  P   
Sbjct: 266 ------------QPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLP--- 310

Query: 929 PQPQAPQQPQQQQQQQP--PPSQQPPPTQQQP 958
           P+P+  +  Q+++  +P  PP +  P +QQ P
Sbjct: 311 PEPKTTKLGQRRESSRPVKPPKKDVPDSQQHP 342



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 37/142 (26%), Positives = 50/142 (35%), Gaps = 18/142 (12%)

Query: 295 PPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMH 354
           PP P  ++P  AAPA  S PPP      P    Q P  +    +  F   ++ + Q  + 
Sbjct: 778 PPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPG-SVFDPIGHFTQPILHLPQPELP 836

Query: 355 HQVPLPPNGQMPG-------------FGLLPTPPFPP----MAQPVIPPTPPVQQPFQAS 397
             +P PP    P                 LP  P  P     A P  P  PP   P    
Sbjct: 837 PHLPQPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQ 896

Query: 398 FQAQNEPLTQKPHQQEMEVEQP 419
                +P   +P Q  +E E+P
Sbjct: 897 TPLLPQPPMAQPPQVLLEDEEP 918



 Score = 36.6 bits (83), Expect = 0.14
 Identities = 20/74 (27%), Positives = 34/74 (45%)

Query: 915  RDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQPQQFRNDNRQQFNSGRD 974
            R   ++  ++ +QQ Q +  QQ QQQQQ     +   P  Q    Q   D +++    R+
Sbjct: 1273 RRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSMLDQQRELARKRE 1332

Query: 975  QERFGRRSFGNRVE 988
            QER  R +    ++
Sbjct: 1333 QERRRREAMAATID 1346



 Score = 35.8 bits (81), Expect = 0.23
 Identities = 93/481 (19%), Positives = 148/481 (30%), Gaps = 113/481 (23%)

Query: 91  NITATFQYLYLCPSEDKSKIVRVLN--LWQKNGVFKIEIIQPLLDMAAG-------TSNA 141
           N   T  Y+Y  P +D   +   L     QK      E  + ++  A G       T  A
Sbjct: 130 NTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRGRGRKETGTA 189

Query: 142 APVAENVTNNEGSPPPPVKVSSEP---PTQATPNSVPAV-PQLPSSDAFAAVAQLFQTTQ 197
            P    V N   +  PP   + +P   P QATP+  PAV P L        V        
Sbjct: 190 KPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVP------ 243

Query: 198 GQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAF 257
                Q LQT   PP P  P    A   Q           P Q      A  P   KT  
Sbjct: 244 ----PQPLQT--PPPVPPQPQPPPAPAPQ-----------PVQSHPPIIAATPQPVKTKK 286

Query: 258 DKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQ 317
             K                 +K DTT  TT  P    P  P             S  P +
Sbjct: 287 GVK-----------------RKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPVK 329

Query: 318 APFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQD-----------PMHHQVPLPPNGQMP 366
            P     D  Q PA  +   + +      GI ++           P +  V +   G   
Sbjct: 330 PPKKDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHD 389

Query: 367 GFGLLPTP---------------------------------PFPPMAQPVIPPTPPVQQP 393
              ++  P                                  + P    V+     +Q  
Sbjct: 390 YCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDV 449

Query: 394 FQASFQAQNEPLTQKPHQQEMEVEQPCIQEVKRHMSDNRKSRSRSASRSPKRRRSRSGSR 453
           F+  F      +  +P +  + V  P +    + ++    S S S S S     +     
Sbjct: 450 FEMRF----AKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEE 505

Query: 454 SRRSR-----------HRRSRSRSRDRRRHSPRSRSQERRDREKERERRQKGLPQVKPET 502
            R  R           H +  + S+  +++ P+ + +++++++KE+ +R++ + + K   
Sbjct: 506 ERAQRLAELQEQLKAVHEQLAALSQP-QQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSK 564

Query: 503 A 503
           A
Sbjct: 565 A 565



 Score = 35.0 bits (79), Expect = 0.40
 Identities = 38/132 (28%), Positives = 48/132 (36%), Gaps = 23/132 (17%)

Query: 289 APAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQF------- 341
           AP    PP P    P    P     PPP  P   P    QQ A     +   F       
Sbjct: 751 APVPQQPPPPPQQPPPPPPPQQQQQPPPPPP---PPSMPQQAAPAMKSSPPPFIATQVPV 807

Query: 342 -QPRMMGIQQDPM-HHQVPLPPNGQMPGFGLLPTPPFPP-MAQPVIPPTPP-VQQPFQAS 397
            +P++ G   DP+ H   P+           LP P  PP + QP    TPP + Q    S
Sbjct: 808 LEPQLPGSVFDPIGHFTQPILH---------LPQPELPPHLPQPPEHSTPPHLNQHAVVS 858

Query: 398 FQAQNEPLTQKP 409
             A +  L Q+P
Sbjct: 859 PPALHNALPQQP 870



 Score = 34.3 bits (77), Expect = 0.68
 Identities = 27/91 (29%), Positives = 34/91 (37%), Gaps = 17/91 (18%)

Query: 315 PPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTP 374
           P     G PG   ++  +  HQ M Q           P+  Q P PP          P P
Sbjct: 723 PKSKKKGHPGREQKKHHHHHHQQMQQAPA--------PVPQQPPPPPQQ--------PPP 766

Query: 375 PFPP-MAQPVIPPTPPVQQPFQASFQAQNEP 404
           P PP   Q   PP PP   P QA+   ++ P
Sbjct: 767 PPPPQQQQQPPPPPPPPSMPQQAAPAMKSSP 797



 Score = 32.3 bits (72), Expect = 2.6
 Identities = 21/60 (35%), Positives = 29/60 (48%), Gaps = 9/60 (15%)

Query: 652  TEPVSPIPKPLPVPVPPIPVPAPITVPP-PQVPPHQPGPPVVGALQPPAFTPPLGIPPPG 710
            +EP SP  +P P P  P  + AP+ +P  P++ P   G PV+         P    PPPG
Sbjct: 1122 SEPFSPSLRPEP-PKHPESIKAPVHLPQRPEMKPVDVGRPVIRP-------PEQNAPPPG 1173


>gi|47132519 Ras association and pleckstrin homology domains 1
           isoform 1 [Homo sapiens]
          Length = 1250

 Score =  103 bits (258), Expect = 7e-22
 Identities = 107/391 (27%), Positives = 130/391 (33%), Gaps = 82/391 (20%)

Query: 649 TSHTEPVSPIPK------------PLPVPVPPIPVPAPITVPPPQVPPHQPGP------- 689
           TS   P+SP PK            PLP P PP P P P   PPP   P Q  P       
Sbjct: 603 TSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAP 662

Query: 690 ------------------------PVVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFL 725
                                   P    +Q  +  P + +PP G    VPPPPPPPP  
Sbjct: 663 MFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGV---VPPPPPPPPPP 719

Query: 726 RPGFNPMHLPPGFLPPG------PPPP-----------ITPPVSIPPPHTPPISIPNLVS 768
            PG     L P    P       PPPP           + PP   PPP  P    P    
Sbjct: 720 TPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPP 779

Query: 769 GARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQ-------PVSLLG-TQGVAPGPVIGL 820
                  +  S K     V  AAP   PTPPV         P S +  +    P PV   
Sbjct: 780 KPLVTIPAPTSTKTVAPVVTQAAPPT-PTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPP 838

Query: 821 QAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPP 880
             P      A+P   PL   P +      +FP   P P PP M  +   P P   A   P
Sbjct: 839 TLPKQQSFCAKPPPSPLSPVPSVVKQIASQFP---PPPTPPAMESQPLKPVPANVAPQSP 895

Query: 881 HGMKGPFPPHGPFVRPGGMPGLGGPGPG-----PGGPEDRDGRQQPPQQPQQQPQPQAPQ 935
             +K   P   P   P   P    P P      P  P        PP  P   P P    
Sbjct: 896 PAVKAK-PKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSG 954

Query: 936 QP-QQQQQQQPPPSQQPPPTQQQPQQFRNDN 965
            P ++  +   P  ++PPPT Q+    ++ +
Sbjct: 955 SPGKKTSKTSSPGGKKPPPTPQRNSSIKSSS 985



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 106/390 (27%), Positives = 135/390 (34%), Gaps = 88/390 (22%)

Query: 649  TSHTEPVSPIPKPLPVPVPPIPVPAP-ITVPPP-----------QVPPHQPGPPVVGALQ 696
            T    P  P P P+P P+PP   P P +T+P P           Q  P  P PPV  A +
Sbjct: 756  TQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKK 815

Query: 697  PPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSI--- 753
             PAF P   IPP    P  PP P PPP L            F    PP P++P  S+   
Sbjct: 816  QPAF-PASYIPP---SPPTPPVPVPPPTLPK-------QQSFCAKPPPSPLSPVPSVVKQ 864

Query: 754  -----PPPHTPPISIPNLVSGARGNA--ESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSL 806
                 PPP TPP      +     N   +S  +VK      P + P   P  P   P S 
Sbjct: 865  IASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESS 924

Query: 807  LGTQGVAPGPVIG-------LQAPSTGLLGARPGLIPLQRPPG--MPPPHLQRFPLM--- 854
            L      P PV           +P+    G+          PG   PPP  QR   +   
Sbjct: 925  LVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSS 984

Query: 855  -------PPRPMPPHMMHRGPPPGPGGF----AMPPPHGMKGPFPPHGPFVRPGGM---- 899
                   P RP    ++ +  PP   G      +PPP     P   +   V   G+    
Sbjct: 985  SGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQG 1044

Query: 900  ------PGLGGPGPG-----PGGPEDRDGRQQPPQQPQQQPQPQAPQ------------- 935
                  P L G G       P  P D D    PP+     P  + P              
Sbjct: 1045 CVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAVV 1104

Query: 936  QPQQQQQQQPPPSQQPPPTQQQPQQFRNDN 965
             PQ QQ  +    + PPPT+ +    RND+
Sbjct: 1105 NPQPQQWSKMSVKKAPPPTRPK----RNDS 1130



 Score = 60.8 bits (146), Expect = 7e-09
 Identities = 74/270 (27%), Positives = 97/270 (35%), Gaps = 73/270 (27%)

Query: 155 PPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAA--VAQLF----QTTQGQQLQQILQTF 208
           P PP+     PP    P   P  P LPS  A +A   A +F      T+ Q   Q     
Sbjct: 624 PSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGAL 683

Query: 209 QQPPKP---QSPALDNAVMAQVQAIT----------------AQLKTTPTQPSEQKAAFP 249
            +PP P   QS ++   ++     +                 AQLK  P  PS  + + P
Sbjct: 684 FKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAP 743

Query: 250 PPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPA 309
           PP  K                              +T  AP    PP P   +PA     
Sbjct: 744 PPPLKI------------------------HQVQHITQVAPPTPPPPPP---IPA----- 771

Query: 310 AASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFG 369
              P PPQAP   P   +  PA T  + +       +  Q  P     P+PP  + P F 
Sbjct: 772 ---PLPPQAP---PKPLVTIPAPTSTKTV-----APVVTQAAPPTPTPPVPPAKKQPAFP 820

Query: 370 ---LLPTPPFPPMAQPVIPPTPPVQQPFQA 396
              + P+PP PP+  PV PPT P QQ F A
Sbjct: 821 ASYIPPSPPTPPV--PVPPPTLPKQQSFCA 848



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 73/289 (25%), Positives = 97/289 (33%), Gaps = 20/289 (6%)

Query: 108 SKIVRVLNLWQKNGVFKIEIIQPLLDMAAGTSNAAPVAENVTNNEGSPPPPVKVSSEPPT 167
           S I R+ N  Q +G     + +P       + +  P      N    PPPP      PP 
Sbjct: 668 STITRLQNASQHSGA----LFKPPTPPVMQSQSVKPQILVPPNGVVPPPPP------PPP 717

Query: 168 QATPNSVPA----VPQLPSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPKP-QSPALDNA 222
             TP S  A     P  PS   F+A     +  Q Q + Q+      PP P  +P    A
Sbjct: 718 PPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQA 777

Query: 223 VMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKL-LDRFDYDDEPEAVEESKKED 281
               +  I A   T    P   +AA P P       KK       Y              
Sbjct: 778 PPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPP 837

Query: 282 TTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQ-PAYTQHQNMDQ 340
            T     +  A  PP+P + VP+     A+  PPP  P       ++  PA    Q+   
Sbjct: 838 PTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPA 897

Query: 341 FQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPP 389
            + +    +  P    VP P     P    L  PP PP   P  PP PP
Sbjct: 898 VKAKP---KWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPP 943



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 70/261 (26%), Positives = 89/261 (34%), Gaps = 36/261 (13%)

Query: 146 ENVTNNEGS----PPPPVKVSS--EPPTQATPNSV--PAVPQLPSSDAFAAVAQLFQTTQ 197
           +N + + G+    P PPV  S   +P     PN V  P  P  P     +A+AQL     
Sbjct: 674 QNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPC 733

Query: 198 GQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAF 257
              L Q    F  PP P         + QVQ IT     TP  P    A  PP     A 
Sbjct: 734 APSLPQ----FSAPPPPLK-------IHQVQHITQVAPPTPPPPPPIPAPLPPQ----AP 778

Query: 258 DKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQ 317
            K L+              S K     VT  AP    PP P A    A   +   P PP 
Sbjct: 779 PKPLVTI--------PAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPT 830

Query: 318 APFGFPGDGM-QQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPF 376
            P   P   + +Q ++          P    ++Q  +  Q P PP    P     P  P 
Sbjct: 831 PPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQ--IASQFPPPPT--PPAMESQPLKPV 886

Query: 377 PPMAQPVIPPTPPVQQPFQAS 397
           P    P  PP    +  +Q S
Sbjct: 887 PANVAPQSPPAVKAKPKWQPS 907



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 66/284 (23%), Positives = 95/284 (33%), Gaps = 72/284 (25%)

Query: 129  QPLLDMAAGTSN--AAPVAENVTNNEGSPP-PPVK------VSSEPPTQATPNSVPAVPQ 179
            +PL+ + A TS    APV         +PP PP K       S  PP+  TP      P 
Sbjct: 780  KPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPT 839

Query: 180  LPSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPT 239
            LP   +F A                    + PP P SP     V + V+ I +Q    PT
Sbjct: 840  LPKQQSFCA--------------------KPPPSPLSP-----VPSVVKQIASQFPPPPT 874

Query: 240  QPSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAP--------- 290
             P+ +     P     A              P AV+   K   +++   +P         
Sbjct: 875  PPAMESQPLKPVPANVA-----------PQSPPAVKAKPKWQPSSIPVPSPDFPPPPPES 923

Query: 291  AAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPG--------DGMQQPAYTQHQN----- 337
            +   PP P + VPA   P   +  P     G PG         G ++P  T  +N     
Sbjct: 924  SLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKS 983

Query: 338  ---MDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPP 378
                +  +P+   +  D +  +   P     P    LP P  PP
Sbjct: 984  SSGAEHPEPKRPSV--DSLVSKFTPPAESGSPSKETLPPPAAPP 1025



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 39/149 (26%), Positives = 54/149 (36%), Gaps = 16/149 (10%)

Query: 283 TAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQ 342
           T  T + P+  +PP P    P    P    PPPP      P  G   P + ++  + + Q
Sbjct: 617 TPYTASQPSPPLPPPPPP--PPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQ 674

Query: 343 ------------PRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPV 390
                       P    +Q   +  Q+ +PPNG +P     P PP P  A   + P P  
Sbjct: 675 NASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCA 734

Query: 391 QQPFQASFQAQNEPLTQKPHQQEMEVEQP 419
             P    F A   PL     Q   +V  P
Sbjct: 735 --PSLPQFSAPPPPLKIHQVQHITQVAPP 761


>gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1
           preproprotein [Homo sapiens]
          Length = 331

 Score =  103 bits (258), Expect = 7e-22
 Identities = 107/338 (31%), Positives = 122/338 (36%), Gaps = 46/338 (13%)

Query: 640 EVAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPA 699
           +V+Q          P  P P+    P  P P P     PPPQ      GPP  G  Q P 
Sbjct: 22  DVSQEESPSLIAGNPQGPSPQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGP- 80

Query: 700 FTPPLGIPP--PGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGPPPPI-TPPVSIPPP 756
             PP G     P   PG P  PPP    +P   P   PP   P GPPP     P   PPP
Sbjct: 81  --PPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPP---PPPGKPQGPPPQGGNRPQGPPPP 135

Query: 757 HTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGP 816
             P           +G    GD  +   S  PP  P   P     QP      QG  P P
Sbjct: 136 GKP-----------QGPPPQGDKSRSPRS--PPGKPQGPPPQGGNQP------QGPPPPP 176

Query: 817 VIGLQAPSTGLLGARP-GLIPLQRPPGMPPP----HLQRFPLMPPRPMPPH--MMHRGPP 869
                 P  G  G +P G  P  +P G PP        + P   P+  PP      +GPP
Sbjct: 177 GKPQGPPPQG--GKKPQGPPPPGKPQGPPPQGDKSRSSQSPPGKPQGPPPQGGNQPQGPP 234

Query: 870 PGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGG--------PGPGPGGPEDRDGRQQP 921
           P PG    PPP G   P  P  P  +P G P  GG        P   P GP  ++G    
Sbjct: 235 PPPGKPQGPPPQGGNKPQGPPPPG-KPQGPPAQGGSKSQSARSPPGKPQGPPQQEGNNPQ 293

Query: 922 PQQPQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQPQ 959
              P     PQ PQ P   Q Q PP   Q     + PQ
Sbjct: 294 GPPPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRPPQ 331



 Score = 87.0 bits (214), Expect = 9e-17
 Identities = 98/324 (30%), Positives = 113/324 (34%), Gaps = 68/324 (20%)

Query: 628 PDWKGIPKKPENEVAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQP 687
           P   G P+ P  +  ++    +   +P  P P+    P  P P P     PPPQ      
Sbjct: 71  PPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNRPQ 130

Query: 688 GPPVVGALQPPAFTPPLG--IPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGPPP 745
           GPP  G  Q P   PP G     P   PG P  PPP    +P   P   PP   P GPPP
Sbjct: 131 GPPPPGKPQGP---PPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPP---PPPGKPQGPPP 184

Query: 746 PITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVS 805
                   PPP   P          +G    GD  K   S  PP  P   P     QP  
Sbjct: 185 QGGKKPQGPPPPGKP----------QGPPPQGD--KSRSSQSPPGKPQGPPPQGGNQP-- 230

Query: 806 LLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMH 865
               QG  P P                      +P G PPP     P  PP P  P    
Sbjct: 231 ----QGPPPPP---------------------GKPQG-PPPQGGNKPQGPPPPGKP---- 260

Query: 866 RGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQP 925
           +GPP   G  +         P  P GP  + G  P   GP P  GG          PQQP
Sbjct: 261 QGPPAQGGSKSQ---SARSPPGKPQGPPQQEGNNP--QGPPPPAGG---------NPQQP 306

Query: 926 QQQP--QPQAPQQPQQQQQQQPPP 947
           Q  P  QPQ P +P Q  +   PP
Sbjct: 307 QAPPAGQPQGPPRPPQGGRPSRPP 330



 Score = 60.5 bits (145), Expect = 9e-09
 Identities = 54/158 (34%), Positives = 63/158 (39%), Gaps = 25/158 (15%)

Query: 839 RPPGMPPPHLQRFPLMPPR------PMPPHMMHRGPPPGPGGFAM---PPPHGMKGPFPP 889
           +P G PPP   + P  PP+      P  P    +GPPP  G       PPP   +GP P 
Sbjct: 67  KPQGPPPPGKPQGP--PPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQ 124

Query: 890 HGPFVRPGGMPGLGGP-GPGPGGPEDRDGR------QQPPQQPQQQPQ-----PQAPQQP 937
            G   RP G P  G P GP P G + R  R      Q PP Q   QPQ     P  PQ P
Sbjct: 125 GGN--RPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGP 182

Query: 938 QQQQQQQPPPSQQPPPTQQQPQQFRNDNRQQFNSGRDQ 975
             Q  ++P     P   Q  P Q       Q   G+ Q
Sbjct: 183 PPQGGKKPQGPPPPGKPQGPPPQGDKSRSSQSPPGKPQ 220



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 39/104 (37%), Positives = 45/104 (43%), Gaps = 22/104 (21%)

Query: 866 RGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGP-GPGPGGPEDRDGRQQPPQQ 924
           +GPPP PG    PPP G            +P G P  G P GP P G + R  R  PP +
Sbjct: 48  QGPPPPPGKPQGPPPQGGN----------KPQGPPPPGKPQGPPPQGDKSRSPRS-PPGK 96

Query: 925 PQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQPQQFRNDNRQQ 968
           PQ  P       PQ   Q Q PP   PPP + Q    +  NR Q
Sbjct: 97  PQGPP-------PQGGNQPQGPP---PPPGKPQGPPPQGGNRPQ 130



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 59/247 (23%), Positives = 72/247 (29%), Gaps = 25/247 (10%)

Query: 143 PVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQ 202
           P  +     +G PPPP K    PP        P  P  P               QG + +
Sbjct: 100 PPPQGGNQPQGPPPPPGKPQGPPPQGGNRPQGPPPPGKPQGPP----------PQGDKSR 149

Query: 203 QILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLL 262
                   P KPQ P        Q           P     +K   PPP  K        
Sbjct: 150 S---PRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGKKPQGPPPPGKPQGPPPQG 206

Query: 263 DRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGF 322
           D+      P    +             P    PP      P         PPPP  P G 
Sbjct: 207 DKSRSSQSPPGKPQGPPPQGGNQPQGPPP---PPGKPQGPPPQGGNKPQGPPPPGKPQGP 263

Query: 323 PGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQP 382
           P  G  +   +Q       +P+    QQ+  + Q P PP G  P       P  PP  QP
Sbjct: 264 PAQGGSK---SQSARSPPGKPQGPP-QQEGNNPQGPPPPAGGNP-----QQPQAPPAGQP 314

Query: 383 VIPPTPP 389
             PP PP
Sbjct: 315 QGPPRPP 321



 Score = 43.9 bits (102), Expect = 9e-04
 Identities = 62/254 (24%), Positives = 76/254 (29%), Gaps = 15/254 (5%)

Query: 150 NNEGSPPPPVKVSSEPPT---QATPNSVPAVPQLP---SSDAFAAVAQLFQTTQGQQLQQ 203
           N    PPPP K    PP      +P S P  PQ P     +            QG   Q 
Sbjct: 66  NKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG 125

Query: 204 ILQTFQQPP--KPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKL 261
             +    PP  KPQ P          ++   + +  P Q   Q    PPP  K       
Sbjct: 126 GNRPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQ 185

Query: 262 LDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPA-PTATVPAAAAPAAASPPPPQAPF 320
             +      P      K +        + ++  PP  P    P         PPPP  P 
Sbjct: 186 GGKKPQGPPPPG----KPQGPPPQGDKSRSSQSPPGKPQGPPPQGGNQPQGPPPPPGKPQ 241

Query: 321 GFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMA 380
           G P  G  +P         Q  P   G +        P  P G     G  P  P PP  
Sbjct: 242 GPPPQGGNKPQGPPPPGKPQGPPAQGGSKSQSARSP-PGKPQGPPQQEGNNPQGPPPPAG 300

Query: 381 -QPVIPPTPPVQQP 393
             P  P  PP  QP
Sbjct: 301 GNPQQPQAPPAGQP 314



 Score = 37.7 bits (86), Expect = 0.062
 Identities = 31/118 (26%), Positives = 41/118 (34%), Gaps = 5/118 (4%)

Query: 276 ESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQH 335
           ++  ED +   + +  A  P  P+   P         PPPP  P G P  G  +P     
Sbjct: 17  QNLNEDVSQEESPSLIAGNPQGPS---PQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPP 73

Query: 336 QNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQP 393
               Q  P      + P     P  P G  P  G  P  P PP  +P  PP     +P
Sbjct: 74  PGKPQGPPPQGDKSRSP--RSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNRP 129


>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
          Length = 1263

 Score =  102 bits (255), Expect = 2e-21
 Identities = 85/232 (36%), Positives = 98/232 (42%), Gaps = 45/232 (19%)

Query: 673 APITVPP--PQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFN 730
           A ITVPP  P   P  P PP+ G        PP   P     P  PPPPPPPP   PG  
Sbjct: 559 AAITVPPSVPSRAPVPPAPPLPG--DSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGV 616

Query: 731 PMHLPPGFLPPG----PPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMYGSA 786
            +  PP  LP G    PPPP++   +IPPP  PP+          G      S    G+A
Sbjct: 617 CISSPPS-LPGGTAISPPPPLSGDATIPPP--PPLP--------EGVGIPSPSSLPGGTA 665

Query: 787 VPPAAP----TNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPG 842
           +PP  P      +P PP   P    G+ G+ P P      P  G  G  P   PL   PG
Sbjct: 666 IPPPPPLPGSARIPPPPPPLP----GSAGIPPPP-----PPLPGEAGMPPPPPPLPGGPG 716

Query: 843 MPPPHLQRFPLMPPRPMPPHMMHRGPPPGPG-GFAMPPPHGMKGPFPPHGPF 893
           +PPP        PP P  P +    PPP PG G   PPP G   P  P  PF
Sbjct: 717 IPPP--------PPFPGGPGI----PPPPPGMGMPPPPPFGFGVPAAPVLPF 756



 Score = 64.7 bits (156), Expect = 5e-10
 Identities = 52/129 (40%), Positives = 65/129 (50%), Gaps = 24/129 (18%)

Query: 645 GGAETSHTEPVS---PIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFT 701
           GG   S   P+S    IP P P+P   + +P+P ++P     P  P PP+ G+ + P   
Sbjct: 626 GGTAISPPPPLSGDATIPPPPPLP-EGVGIPSPSSLPGGTAIP--PPPPLPGSARIPPPP 682

Query: 702 PPL----GIPPP----GFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGPP--PPITPPV 751
           PPL    GIPPP        G+PPPPPP P   PG  P   PP F  PG P  PP  P +
Sbjct: 683 PPLPGSAGIPPPPPPLPGEAGMPPPPPPLPG-GPGIPP---PPPF--PGGPGIPPPPPGM 736

Query: 752 SIPPPHTPP 760
            +PPP  PP
Sbjct: 737 GMPPP--PP 743



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 55/189 (29%), Positives = 66/189 (34%), Gaps = 33/189 (17%)

Query: 787 VPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPP 846
           VPP+ P+  P PP        GT  + P P      P+ G     P   P   PP  PPP
Sbjct: 563 VPPSVPSRAPVPPAPPLPGDSGT--IIPPP------PAPGDSTTPP---PPPPPPPPPPP 611

Query: 847 -----HLQRFP-------LMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKG-----PFPP 889
                 +   P       + PP P+        PPP P G  +P P  + G     P PP
Sbjct: 612 LPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPP 671

Query: 890 HGPFVR----PGGMPGLGG-PGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQ 944
                R    P  +PG  G P P P  P +      PP  P     P  P  P       
Sbjct: 672 LPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPP 731

Query: 945 PPPSQQPPP 953
           PPP    PP
Sbjct: 732 PPPGMGMPP 740



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 39/140 (27%), Positives = 55/140 (39%), Gaps = 23/140 (16%)

Query: 274 VEESKKE--DTTAVTTTAPA-----AAVPPAPT------ATVPAAAAPAAAS-----PPP 315
           +E++KKE    +A   T P      A VPPAP         +P   AP  ++     PPP
Sbjct: 546 LEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPP 605

Query: 316 PQAPFGFPGDG-MQQPAYTQHQNMDQFQPRMMGIQQ----DPMHHQVPLPPNGQMPGFGL 370
           P  P   PG   +  P            P + G        P+   V +P    +PG   
Sbjct: 606 PPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTA 665

Query: 371 LPTPPFPPMAQPVIPPTPPV 390
           +P PP  P +  + PP PP+
Sbjct: 666 IPPPPPLPGSARIPPPPPPL 685



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 41/179 (22%), Positives = 52/179 (29%), Gaps = 49/179 (27%)

Query: 211 PPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRFDYDDE 270
           PP P  P      ++   ++      +P  P    A  PPP                   
Sbjct: 605 PPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPL---------------- 648

Query: 271 PEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQP 330
           PE V           T   P   +P +     P    P +A  PPP  P   PG+     
Sbjct: 649 PEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPP--LPGEA---- 702

Query: 331 AYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPP 389
                                     +P PP     G G+ P PPFP    P IPP PP
Sbjct: 703 -------------------------GMPPPPPPLPGGPGIPPPPPFP--GGPGIPPPPP 734



 Score = 37.4 bits (85), Expect = 0.081
 Identities = 34/104 (32%), Positives = 38/104 (36%), Gaps = 33/104 (31%)

Query: 628 PDWKGIPKKPENEVAQNGGAETSHTEPVSPIPKPLP----VPVPPIPVPAPITVPPPQVP 683
           P   GIP  P     + G         + P P PLP    +P PP P P    +PPP   
Sbjct: 686 PGSAGIPPPPPPLPGEAG---------MPPPPPPLPGGPGIPPPP-PFPGGPGIPPP--- 732

Query: 684 PHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRP 727
                        PP    P   PPP FG GVP  P  P  L P
Sbjct: 733 -------------PPGMGMP---PPPPFGFGVPAAPVLPFGLTP 760



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 40/127 (31%), Positives = 47/127 (37%), Gaps = 25/127 (19%)

Query: 852 PLMPPR-PMPPHMMHRGPP-PGPGGFAMPPPHG-------MKGPFPPHGPFVRPGGM--- 899
           P +P R P+PP      PP PG  G  +PPP            P PP  P   PGG+   
Sbjct: 565 PSVPSRAPVPP-----APPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCIS 619

Query: 900 --PGL-GGPGPGPGGPEDRDGR-QQPPQQPQQQPQPQAPQQPQQQQQQQPPP----SQQP 951
             P L GG    P  P   D     PP  P+    P     P       PPP    ++ P
Sbjct: 620 SPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIP 679

Query: 952 PPTQQQP 958
           PP    P
Sbjct: 680 PPPPPLP 686


>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
          Length = 1272

 Score =  102 bits (255), Expect = 2e-21
 Identities = 85/232 (36%), Positives = 98/232 (42%), Gaps = 45/232 (19%)

Query: 673 APITVPP--PQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFN 730
           A ITVPP  P   P  P PP+ G        PP   P     P  PPPPPPPP   PG  
Sbjct: 568 AAITVPPSVPSRAPVPPAPPLPG--DSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGV 625

Query: 731 PMHLPPGFLPPG----PPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMYGSA 786
            +  PP  LP G    PPPP++   +IPPP  PP+          G      S    G+A
Sbjct: 626 CISSPPS-LPGGTAISPPPPLSGDATIPPP--PPLP--------EGVGIPSPSSLPGGTA 674

Query: 787 VPPAAP----TNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPG 842
           +PP  P      +P PP   P    G+ G+ P P      P  G  G  P   PL   PG
Sbjct: 675 IPPPPPLPGSARIPPPPPPLP----GSAGIPPPP-----PPLPGEAGMPPPPPPLPGGPG 725

Query: 843 MPPPHLQRFPLMPPRPMPPHMMHRGPPPGPG-GFAMPPPHGMKGPFPPHGPF 893
           +PPP        PP P  P +    PPP PG G   PPP G   P  P  PF
Sbjct: 726 IPPP--------PPFPGGPGI----PPPPPGMGMPPPPPFGFGVPAAPVLPF 765



 Score = 64.7 bits (156), Expect = 5e-10
 Identities = 52/129 (40%), Positives = 65/129 (50%), Gaps = 24/129 (18%)

Query: 645 GGAETSHTEPVS---PIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFT 701
           GG   S   P+S    IP P P+P   + +P+P ++P     P  P PP+ G+ + P   
Sbjct: 635 GGTAISPPPPLSGDATIPPPPPLP-EGVGIPSPSSLPGGTAIP--PPPPLPGSARIPPPP 691

Query: 702 PPL----GIPPP----GFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGPP--PPITPPV 751
           PPL    GIPPP        G+PPPPPP P   PG  P   PP F  PG P  PP  P +
Sbjct: 692 PPLPGSAGIPPPPPPLPGEAGMPPPPPPLPG-GPGIPP---PPPF--PGGPGIPPPPPGM 745

Query: 752 SIPPPHTPP 760
            +PPP  PP
Sbjct: 746 GMPPP--PP 752



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 55/189 (29%), Positives = 66/189 (34%), Gaps = 33/189 (17%)

Query: 787 VPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPP 846
           VPP+ P+  P PP        GT  + P P      P+ G     P   P   PP  PPP
Sbjct: 572 VPPSVPSRAPVPPAPPLPGDSGT--IIPPP------PAPGDSTTPP---PPPPPPPPPPP 620

Query: 847 -----HLQRFP-------LMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKG-----PFPP 889
                 +   P       + PP P+        PPP P G  +P P  + G     P PP
Sbjct: 621 LPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPP 680

Query: 890 HGPFVR----PGGMPGLGG-PGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQ 944
                R    P  +PG  G P P P  P +      PP  P     P  P  P       
Sbjct: 681 LPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPP 740

Query: 945 PPPSQQPPP 953
           PPP    PP
Sbjct: 741 PPPGMGMPP 749



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 39/140 (27%), Positives = 55/140 (39%), Gaps = 23/140 (16%)

Query: 274 VEESKKE--DTTAVTTTAPA-----AAVPPAPT------ATVPAAAAPAAAS-----PPP 315
           +E++KKE    +A   T P      A VPPAP         +P   AP  ++     PPP
Sbjct: 555 LEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPP 614

Query: 316 PQAPFGFPGDG-MQQPAYTQHQNMDQFQPRMMGIQQ----DPMHHQVPLPPNGQMPGFGL 370
           P  P   PG   +  P            P + G        P+   V +P    +PG   
Sbjct: 615 PPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTA 674

Query: 371 LPTPPFPPMAQPVIPPTPPV 390
           +P PP  P +  + PP PP+
Sbjct: 675 IPPPPPLPGSARIPPPPPPL 694



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 41/179 (22%), Positives = 52/179 (29%), Gaps = 49/179 (27%)

Query: 211 PPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRFDYDDE 270
           PP P  P      ++   ++      +P  P    A  PPP                   
Sbjct: 614 PPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPL---------------- 657

Query: 271 PEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQP 330
           PE V           T   P   +P +     P    P +A  PPP  P   PG+     
Sbjct: 658 PEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPP--LPGEA---- 711

Query: 331 AYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPP 389
                                     +P PP     G G+ P PPFP    P IPP PP
Sbjct: 712 -------------------------GMPPPPPPLPGGPGIPPPPPFP--GGPGIPPPPP 743



 Score = 37.4 bits (85), Expect = 0.081
 Identities = 34/104 (32%), Positives = 38/104 (36%), Gaps = 33/104 (31%)

Query: 628 PDWKGIPKKPENEVAQNGGAETSHTEPVSPIPKPLP----VPVPPIPVPAPITVPPPQVP 683
           P   GIP  P     + G         + P P PLP    +P PP P P    +PPP   
Sbjct: 695 PGSAGIPPPPPPLPGEAG---------MPPPPPPLPGGPGIPPPP-PFPGGPGIPPP--- 741

Query: 684 PHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRP 727
                        PP    P   PPP FG GVP  P  P  L P
Sbjct: 742 -------------PPGMGMP---PPPPFGFGVPAAPVLPFGLTP 769



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 40/127 (31%), Positives = 47/127 (37%), Gaps = 25/127 (19%)

Query: 852 PLMPPR-PMPPHMMHRGPP-PGPGGFAMPPPHG-------MKGPFPPHGPFVRPGGM--- 899
           P +P R P+PP      PP PG  G  +PPP            P PP  P   PGG+   
Sbjct: 574 PSVPSRAPVPP-----APPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCIS 628

Query: 900 --PGL-GGPGPGPGGPEDRDGR-QQPPQQPQQQPQPQAPQQPQQQQQQQPPP----SQQP 951
             P L GG    P  P   D     PP  P+    P     P       PPP    ++ P
Sbjct: 629 SPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIP 688

Query: 952 PPTQQQP 958
           PP    P
Sbjct: 689 PPPPPLP 695


>gi|162329583 cleavage and polyadenylation specific factor 6, 68 kD
            subunit [Homo sapiens]
          Length = 551

 Score =  102 bits (255), Expect = 2e-21
 Identities = 123/413 (29%), Positives = 154/413 (37%), Gaps = 128/413 (30%)

Query: 691  VVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGPPPPITPP 750
            V G  + P    P G PPP      PP PP  P   PG      PPG  PPGPPP   P 
Sbjct: 211  VPGGDRFPGPAGPGGPPPPFPAGQTPPRPPLGP---PG------PPG--PPGPPP---PG 256

Query: 751  VSIPPPHTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQ 810
              +PPP   P   PN     RG+               P  P   P  P  QP   LG  
Sbjct: 257  QVLPPPLAGP---PN-----RGDR--------------PPPPVLFPGQPFGQPP--LGPL 292

Query: 811  GVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPP 870
               P P +             PG  P   PPG PPP  Q+ P  PP P PP       PP
Sbjct: 293  PPGPPPPV-------------PGYGP---PPGPPPP--QQGPPPPPGPFPPR------PP 328

Query: 871  GPGGFAM---PPPHGMKGP---FPPHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQ 924
            GP G  +   PPPH + GP    PP  P V P        P P   G    D R  PP  
Sbjct: 329  GPLGPPLTLAPPPH-LPGPPPGAPPPAPHVNPAFF-----PPPTNSGMPTSDSRGPPPTD 382

Query: 925  PQQQPQPQAPQQPQQQQQQQPPPSQQ-----PPPTQQQPQQFRNDNRQQFNS--GRDQER 977
            P  +P       P   +    PP ++      P ++ + ++  N NR   +S   R    
Sbjct: 383  PYGRP-------PPYDRGDYGPPGREMDTARTPLSEAEFEEIMNRNRAISSSAISRAVSD 435

Query: 978  FGRRSFGNRVEN---------------------------------DRERYGN-----RND 999
                 +G+ +E                                  + + YG+     R+ 
Sbjct: 436  ASAGDYGSAIETLVTAISLIKQSKVSADDRCKVLISSLQDCLHGIESKSYGSGSRRERSR 495

Query: 1000 DRDNSNRDRREWGRRSPDRDRHRD-LEERNRRSSGHRDRERDSRDRESRREKE 1051
            +RD+S    +    +S  RDRH D   ER+R    HRDR+RD RDRE  RE+E
Sbjct: 496  ERDHSRSREKSRRHKSRSRDRHDDYYRERSRERERHRDRDRD-RDRERDRERE 547



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 113/390 (28%), Positives = 146/390 (37%), Gaps = 98/390 (25%)

Query: 708  PPGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNLV 767
            P   GPG PPPP P     P   P   PPG  PPGPP P  P   +PPP   P   PN  
Sbjct: 218  PGPAGPGGPPPPFPAGQTPP--RPPLGPPG--PPGPPGPPPPGQVLPPPLAGP---PN-- 268

Query: 768  SGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGL 827
               RG+               P  P   P  P  QP   LG     P P +         
Sbjct: 269  ---RGDR--------------PPPPVLFPGQPFGQPP--LGPLPPGPPPPV--------- 300

Query: 828  LGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAM---PPPHGMK 884
                PG  P   PPG PPP  Q+ P  PP P PP       PPGP G  +   PPPH + 
Sbjct: 301  ----PGYGP---PPGPPPP--QQGPPPPPGPFPPR------PPGPLGPPLTLAPPPH-LP 344

Query: 885  GP---FPPHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQ 941
            GP    PP  P V P   P      P   G    D R  PP  P  +P P         +
Sbjct: 345  GPPPGAPPPAPHVNPAFFPP-----PTNSGMPTSDSRGPPPTDPYGRPPPY-------DR 392

Query: 942  QQQPPPSQQ-----PPPTQQQPQQFRNDNRQQFNSG--RDQERFGRRSFGNRVEN----- 989
                PP ++      P ++ + ++  N NR   +S   R         +G+ +E      
Sbjct: 393  GDYGPPGREMDTARTPLSEAEFEEIMNRNRAISSSAISRAVSDASAGDYGSAIETLVTAI 452

Query: 990  -----DRERYGNRNDDRDNSNRD------RREWGRRSP-DRDRHRDLEERNRRSSGHRDR 1037
                  +    +R     +S +D       + +G  S  +R R RD      +S  H+ R
Sbjct: 453  SLIKQSKVSADDRCKVLISSLQDCLHGIESKSYGSGSRRERSRERDHSRSREKSRRHKSR 512

Query: 1038 ERDSRD---RESRREKEEARGKEKPEVTDR 1064
             RD  D   RE  RE+E  R +++    +R
Sbjct: 513  SRDRHDDYYRERSRERERHRDRDRDRDRER 542



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 78/227 (34%), Positives = 86/227 (37%), Gaps = 44/227 (19%)

Query: 659 PKPLPVPVPPIPVPAPITVP-PPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPP 717
           P P     PP P PA  T P PP  PP  PGPP      PP   P   +PPP  GP    
Sbjct: 218 PGPAGPGGPPPPFPAGQTPPRPPLGPPGPPGPP-----GPPP--PGQVLPPPLAGPPNRG 270

Query: 718 PPPPPPFLRPGFNPMHLPP-GFLPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAES 776
             PPPP L PG  P   PP G LPPGPPPP+  P   PPP  PP                
Sbjct: 271 DRPPPPVLFPG-QPFGQPPLGPLPPGPPPPV--PGYGPPPGPPP---------------- 311

Query: 777 GDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIP 836
                  G   PP      P  P+  P++L     + PGP  G   P+           P
Sbjct: 312 ----PQQGPPPPPGPFPPRPPGPLGPPLTLAPPPHL-PGPPPGAPPPA-----------P 355

Query: 837 LQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGM 883
              P   PPP     P    R  PP   +  PPP   G   PP   M
Sbjct: 356 HVNPAFFPPPTNSGMPTSDSRGPPPTDPYGRPPPYDRGDYGPPGREM 402



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 53/117 (45%), Positives = 62/117 (52%), Gaps = 16/117 (13%)

Query: 652 TEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPP----HQPGPPVVGALQPPAFTPPLGIP 707
           T P  P+  P P P PP P P    +PPP   P     +P PPV+   QP    PPLG  
Sbjct: 235 TPPRPPLGPPGP-PGPPGPPPPGQVLPPPLAGPPNRGDRPPPPVLFPGQPFG-QPPLGPL 292

Query: 708 PPGFGPGV----PPPPPPPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSI-PPPHTP 759
           PPG  P V    PPP PPPP  + G  P   PPG  PP PP P+ PP+++ PPPH P
Sbjct: 293 PPGPPPPVPGYGPPPGPPPP--QQGPPP---PPGPFPPRPPGPLGPPLTLAPPPHLP 344



 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 47/113 (41%), Positives = 54/113 (47%), Gaps = 19/113 (16%)

Query: 654 PVSPIPKPLPVPVP---PIPVPAPITVPPPQVPPHQPGPPVVGALQPPA-FTPPLGIPPP 709
           P+ P+P   P PVP   P P P P    PP  PP  P PP     +PP    PPL + PP
Sbjct: 288 PLGPLPPGPPPPVPGYGPPPGPPPPQQGPP--PPPGPFPP-----RPPGPLGPPLTLAPP 340

Query: 710 GFGPGVPP-PPPPPPFLRPGFNPMHLPPGFLPP----GPPPPITPPVSIPPPH 757
              PG PP  PPP P + P F P     G +P     GPPP  T P   PPP+
Sbjct: 341 PHLPGPPPGAPPPAPHVNPAFFPPPTNSG-MPTSDSRGPPP--TDPYGRPPPY 390



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 32/78 (41%), Positives = 41/78 (52%), Gaps = 4/78 (5%)

Query: 418 QPCIQ--EVKRHMSDNRKSRSRSASRSPKRRRSRSGSRSRRSRHRRS-RSRSRDRRRHSP 474
           Q C+   E K + S +R+ RSR    S  R +SR      R RH    R RSR+R RH  
Sbjct: 474 QDCLHGIESKSYGSGSRRERSRERDHSRSREKSRRHKSRSRDRHDDYYRERSRERERHRD 533

Query: 475 RSRSQER-RDREKERERR 491
           R R ++R RDRE+E   R
Sbjct: 534 RDRDRDRERDREREYRHR 551



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 57/253 (22%), Positives = 80/253 (31%), Gaps = 55/253 (21%)

Query: 290 PAAAVPPAPTATVPAAAAPAAASPPPPQAPF------------------GFPGDGMQQPA 331
           P    PP P    P    P    PPPP  PF                    PG     P 
Sbjct: 293 PPGPPPPVPGYGPPPGPPPPQQGPPPPPGPFPPRPPGPLGPPLTLAPPPHLPGPPPGAPP 352

Query: 332 YTQHQNMDQF-QPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPV 390
              H N   F  P   G+         P  P G+ P +       + P  + +     P+
Sbjct: 353 PAPHVNPAFFPPPTNSGMPTSDSRGPPPTDPYGRPPPY---DRGDYGPPGREMDTARTPL 409

Query: 391 QQPFQASFQAQNEPLTQKP---------------------------HQQEMEVEQPCIQE 423
            +        +N  ++                               Q ++  +  C   
Sbjct: 410 SEAEFEEIMNRNRAISSSAISRAVSDASAGDYGSAIETLVTAISLIKQSKVSADDRCKVL 469

Query: 424 VKRHMSDNRKSRSRSASRSPKRRRSRSGSRSR-RSRHRRSRSRSRDRRRHSPRSRSQER- 481
           +           S+S     +R RSR    SR R + RR +SRSRDR     R RS+ER 
Sbjct: 470 ISSLQDCLHGIESKSYGSGSRRERSRERDHSRSREKSRRHKSRSRDRHDDYYRERSRERE 529

Query: 482 ----RDREKERER 490
               RDR+++RER
Sbjct: 530 RHRDRDRDRDRER 542



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 34/94 (36%), Positives = 37/94 (39%), Gaps = 9/94 (9%)

Query: 867 GPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGG--MPGLGGPGPGPGGPEDRDGRQQPPQQ 924
           GPP G    A P     +G FP       PGG   PG  GPG   G P      Q PP+ 
Sbjct: 187 GPPGGSSRAAFPQGGRGRGRFPG----AVPGGDRFPGPAGPG---GPPPPFPAGQTPPRP 239

Query: 925 PQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQP 958
           P   P P  P  P    Q  PPP   PP    +P
Sbjct: 240 PLGPPGPPGPPGPPPPGQVLPPPLAGPPNRGDRP 273



 Score = 39.3 bits (90), Expect = 0.021
 Identities = 26/78 (33%), Positives = 32/78 (41%), Gaps = 9/78 (11%)

Query: 967  QQFNSGRDQERFGRRSFGNRVENDRERYGNRNDDRDNSNRDRREWGRRSPDRDRHRDLEE 1026
            + + SG  +ER   R      E  R       D  D+  R+R     R  DRDR RD E 
Sbjct: 483  KSYGSGSRRERSRERDHSRSREKSRRHKSRSRDRHDDYYRERSRERERHRDRDRDRDRE- 541

Query: 1027 RNRRSSGHRDRERDSRDR 1044
                    RDRER+ R R
Sbjct: 542  --------RDREREYRHR 551



 Score = 38.9 bits (89), Expect = 0.028
 Identities = 35/111 (31%), Positives = 40/111 (36%), Gaps = 21/111 (18%)

Query: 290 PAAAVPPAPTATVPAAAAPAAASPP-----PPQAPFGFPGDGMQQPAYTQHQNMDQFQPR 344
           PA   PP P    P    P    PP     PP A  G P  G + P           QP 
Sbjct: 231 PAGQTPPRPPLGPPGPPGPPGPPPPGQVLPPPLA--GPPNRGDRPPPPVLFPGQPFGQPP 288

Query: 345 MMGIQQDPMHHQVPLPPNGQ--MPGFGLLPTPPFPPMAQPVIPPTPPVQQP 393
           +            PLPP     +PG+G  P PP PP   P  PP P   +P
Sbjct: 289 LG-----------PLPPGPPPPVPGYGPPPGPP-PPQQGPPPPPGPFPPRP 327



 Score = 30.8 bits (68), Expect = 7.6
 Identities = 16/36 (44%), Positives = 17/36 (47%), Gaps = 1/36 (2%)

Query: 358 PLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQP 393
           P  P G  P F    TPP PP+  P  PP PP   P
Sbjct: 220 PAGPGGPPPPFPAGQTPPRPPLGPPG-PPGPPGPPP 254


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score =  102 bits (255), Expect = 2e-21
 Identities = 105/367 (28%), Positives = 137/367 (37%), Gaps = 72/367 (19%)

Query: 657 PIPKPLPVPVPPIPVPA---PITVPPPQVPPH--QPGPPVVGALQPPAFTPPLGIPPPGF 711
           P  + L     P+  PA   P     P+ P H  QP P  + AL+PP  TPP     P  
Sbjct: 228 PASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPAL 287

Query: 712 G-----------PGVPPPPPPPPFLRPGFNPMHLPP----------------GFLPPGP- 743
           G           P  PP P  PP L+   +P   PP                 FLP  P 
Sbjct: 288 GPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPL 347

Query: 744 -----PPPITPP-VSIPP---PHTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTN 794
                PPP  PP +++PP   P +PP S P L   A  + ++ +++ ++    P + P  
Sbjct: 348 SPLATPPPQAPPALALPPLQAPPSPPAS-PPLSPLATPSPQAPNALAVHLLQAPFSPP-- 404

Query: 795 LPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFP-- 852
            P+PPV  P S   +  V+P      QAP +  L A P  +P   PP  PP      P  
Sbjct: 405 -PSPPVQAPFSPPASPPVSPSATPPSQAPPS--LAAPPLQVP-PSPPASPPMSPSATPPP 460

Query: 853 -LMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGP---FPPHGPFVRPGGMPGLGGPGPG 908
              PP   PP  + + PP  P   A PP   +  P   FP   PF     +P      P 
Sbjct: 461 QAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPP 520

Query: 909 PGGPEDRDG-RQQPPQQPQQQPQPQAPQQPQQQQQQ----------------QPPPSQQP 951
           P  P        Q P  P   P  QAP++P                       PPPS+ P
Sbjct: 521 PQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSP 580

Query: 952 PPTQQQP 958
             T   P
Sbjct: 581 SSTLSGP 587



 Score = 90.5 bits (223), Expect = 8e-18
 Identities = 96/360 (26%), Positives = 125/360 (34%), Gaps = 61/360 (16%)

Query: 634 PKKPENEVAQNGGAETSH-TEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPVV 692
           P  P ++   + G+ T   T    P P   P+  PP   P  + +PP Q PP  P  P +
Sbjct: 319 PATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPL 378

Query: 693 GALQPPAFTPPLGI----------PPPGFGPGVPPPPPPPPFLRPGFNP-------MHLP 735
             L  P+   P  +          PPP      P  PP  P + P   P       +  P
Sbjct: 379 SPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAP 438

Query: 736 PGFLPPGPP--PPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPT 793
           P  +PP PP  PP++P  + PP   PP++ P L                  +  PP AP 
Sbjct: 439 PLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQL----------------AKPPPQAPP 482

Query: 794 NLPTPPV----TQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIP--LQRPPGMPPPH 847
            L TPP+    + P S  G    +P   + +   +T    A P L    LQ PP  P   
Sbjct: 483 ALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASP 542

Query: 848 LQRFPLMPPRPMPPHMMHRGP------PPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPG 901
             + P  PP P P   +  GP       PGP     PPP          GP +       
Sbjct: 543 TLQAPRRPPTPGPDTSV-SGPRLTLALAPGP-----PPPPSRSPSSTLSGPDLAGHSSSA 596

Query: 902 LGGPGPGPG---GPEDRDGRQQPPQQPQQQPQPQA----PQQPQQQQQQQPPPSQQPPPT 954
              P    G   GPE       PP        P A    P  P   +     P   PP T
Sbjct: 597 TSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPAT 656



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 85/280 (30%), Positives = 101/280 (36%), Gaps = 44/280 (15%)

Query: 654 PVSPIPKP--LPVPVPPIPVPAPITVPPPQVPPHQPGPPVV--GALQPPAFTPPLGIPPP 709
           P SP   P   P   PP   P  +  PP QVPP  P  P +   A  PP   PPL  PP 
Sbjct: 412 PFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPL 471

Query: 710 GFGPGVPPPPPPPPFLRPGFNPMHLPPGFLP---PGPPPPITP--PVSIPPPHTPPISIP 764
                 PPP  PP    P    +  PP   P   P  P    P  P++ PPP  PP+   
Sbjct: 472 QLAK--PPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAA 529

Query: 765 NLVSGARGNAESGDSVKMYGSAVPPAAPT-----NLPTP-PVTQPVSLLGTQGVAPG-PV 817
            L+                    PPA+PT       PTP P T       T  +APG P 
Sbjct: 530 PLLQVPPS---------------PPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPP 574

Query: 818 IGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAM 877
              ++PS+ L G  P L          P  L+ +   P            PPP     A 
Sbjct: 575 PPSRSPSSTLSG--PDLAGHSSSATSTPEELRGYDSGPEGGAA-----ASPPPDAELAAC 627

Query: 878 PPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDG 917
            P    +GP PP    +   G PG   P P   GP   DG
Sbjct: 628 HPAAWSRGPAPP----LAFRGAPGAPLPWPPATGPGSADG 663



 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 101/347 (29%), Positives = 120/347 (34%), Gaps = 54/347 (15%)

Query: 634 PKKPENEVAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPVV- 692
           P  P   +A+   A  + TE   P P P   P PP   P        +    +P P    
Sbjct: 160 PGTPSPAMARRSRA--AGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARR 217

Query: 693 -----GALQPPAF------TPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPP 741
                G LQ PA         PL  P    GP     P  P       +P    P  L  
Sbjct: 218 RPSAGGGLQRPASRSLSSSATPLSSPARS-GPSARGTPRAPA------HPSQPKPKGLQA 270

Query: 742 GPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVT 801
             PP +TPP     P   P+S   L + +     S         + PP+  T LP+PP T
Sbjct: 271 LRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPS--------PSAPPSLQT-LPSPPAT 321

Query: 802 QPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPP 861
            P     + G        LQA  + L    P L PL  PP   PP L   PL  P P PP
Sbjct: 322 PPSQATTSLGSPT-----LQATHSFL--PSPPLSPLATPPPQAPPALALPPLQAP-PSPP 373

Query: 862 HMMHRGP-----PPGPGGFAMPPPHGMKGPF-PPHGPFVRPGGMPGLGGPGPGPGGPEDR 915
                 P     P  P   A+   H ++ PF PP  P V+    P    P   P  P   
Sbjct: 374 ASPPLSPLATPSPQAPNALAV---HLLQAPFSPPPSPPVQAPFSP----PASPPVSPSAT 426

Query: 916 DGRQQPPQ--QPQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQPQQ 960
              Q PP    P  Q  P  P  P       PPP Q PPP    P Q
Sbjct: 427 PPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPP-QAPPPLAAPPLQ 472



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 76/287 (26%), Positives = 107/287 (37%), Gaps = 51/287 (17%)

Query: 135 AAGTSNAAPVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQ 194
           A G  +++P+A   T +  +PP P    S PP+  T  S PA P  PS    +  +   Q
Sbjct: 286 ALGPLSSSPLA---TPSPSAPPSP----SAPPSLQTLPSPPATP--PSQATTSLGSPTLQ 336

Query: 195 TTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQK 254
            T        L     PP    PAL    +  +QA  +   + P  P     A P P+  
Sbjct: 337 ATHSFLPSPPLSPLATPPPQAPPAL---ALPPLQAPPSPPASPPLSP----LATPSPQAP 389

Query: 255 TAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPP 314
            A    LL    +   P    ++           +P A+ P +P+AT P+ A P+ A+PP
Sbjct: 390 NALAVHLLQA-PFSPPPSPPVQAP---------FSPPASPPVSPSATPPSQAPPSLAAPP 439

Query: 315 ----------PPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPP--- 361
                     PP +P   P      P       + +  P+       P    +P PP   
Sbjct: 440 LQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASF 499

Query: 362 NGQMP--GFGLLPTPPF---PPMAQPV-------IPPTPPVQQPFQA 396
            GQ P      LP  P    PP A PV       +PP+PP     QA
Sbjct: 500 PGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQA 546



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 74/274 (27%), Positives = 93/274 (33%), Gaps = 54/274 (19%)

Query: 633 IPKKPENEVAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGP-PV 691
           +P  P      +  A      P      PL +  PP   P  +  PP Q  P  P   P 
Sbjct: 442 VPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPG 501

Query: 692 VGALQPPAFTP--PLGIPPPGFGP-------GVPPPPPPPPFLRPGFNPMHLPPG----- 737
                P A  P  PL  PPP   P        VPP PP  P L+    P    P      
Sbjct: 502 QAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSG 561

Query: 738 -----FLPPGPPPP--ITPPVSIPPPH---------TPPISIPNLVSGARGNAESGDSVK 781
                 L PGPPPP   +P  ++  P          + P  +    SG  G A +     
Sbjct: 562 PRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPD 621

Query: 782 MYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPP 841
              +A  PAA +  P P    P++  G  G AP P      P+TG  G+  GL  +    
Sbjct: 622 AELAACHPAAWSRGPAP----PLAFRGAPG-APLP----WPPATG-PGSADGLCTIYETE 671

Query: 842 GMPPPHLQRFPLMPPRPMP-PHMMHRGPPPGPGG 874
           G            P    P P  +  GP PG  G
Sbjct: 672 G------------PESATPAPGALDPGPSPGTSG 693



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 62/259 (23%), Positives = 80/259 (30%), Gaps = 41/259 (15%)

Query: 154 SPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPK 213
           S P P  + +  P Q TP    A P L    +                   LQT   PP 
Sbjct: 261 SQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPA 320

Query: 214 -PQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPE 272
            P S A  +     +QA  + L + P  P     A PPP+   A     L          
Sbjct: 321 TPPSQATTSLGSPTLQATHSFLPSPPLSP----LATPPPQAPPALALPPL---------- 366

Query: 273 AVEESKKEDTTAVTTTAPAAAVPPAPTA-TVPAAAAPAAASPPPP-QAPFGFPGDGMQQP 330
              ++      +   +  A   P AP A  V    AP +  P PP QAPF  P      P
Sbjct: 367 ---QAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSP 423

Query: 331 AYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPV 390
           + T                          PP+   P   + P+PP  P   P   P P  
Sbjct: 424 SATPPSQA---------------------PPSLAAPPLQVPPSPPASPPMSPSATPPPQA 462

Query: 391 QQPFQASFQAQNEPLTQKP 409
             P  A      +P  Q P
Sbjct: 463 PPPLAAPPLQLAKPPPQAP 481



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 64/261 (24%), Positives = 82/261 (31%), Gaps = 31/261 (11%)

Query: 154 SPP--PPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQQILQTFQQP 211
           SPP  PPV  S+ PP+QA P+      Q+P S   +       T   Q    +     Q 
Sbjct: 414 SPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQL 473

Query: 212 PKPQSPALDNAVMAQVQAITAQLKTTPTQ----PSEQ----KAAFPPPEQKTAFDKKLLD 263
            KP   A        +QA+ +   + P Q    PS        A PPP+        LL 
Sbjct: 474 AKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQ 533

Query: 264 RFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFP 323
                  P A          + T  AP     P P  +V       A +P PP  P   P
Sbjct: 534 ---VPPSPPA----------SPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSP 580

Query: 324 GDGMQQPAYTQHQNMDQFQP-RMMGIQQDPMHHQVPLPPNG------QMPGFGLLPTPPF 376
              +  P    H +     P  + G    P       PP            +   P PP 
Sbjct: 581 SSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPL 640

Query: 377 PPMAQPVIP-PTPPVQQPFQA 396
                P  P P PP   P  A
Sbjct: 641 AFRGAPGAPLPWPPATGPGSA 661



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 86/362 (23%), Positives = 103/362 (28%), Gaps = 102/362 (28%)

Query: 694 ALQPPAFTPPLGIPPPGFGPGVPPPPPP--PPFLRP-----------------GFNPMHL 734
           A  P A  P L  P P   PG P PPPP  P  LR                  G     +
Sbjct: 14  ARTPAARAPGLLTPRP---PGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATI 70

Query: 735 PPGFLPPGPPPPITPPVS-----IPPPHTP---PISIPNLVSG----------------- 769
           P      GP     PP S      PP       P+S P   SG                 
Sbjct: 71  PESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAE 130

Query: 770 ---ARGNAESGD--SVKMYGSAVPPAAPT-NLPTPPVTQPVSLLGTQGVAPGPVIGL--- 820
              ARG A      S    G+    + PT   P+P + +     GT+   P P       
Sbjct: 131 ETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPR 190

Query: 821 ---QAPSTGLLGA------RPGLIPLQRPP---GMPPPHLQRF-----PLMPPRPMPPHM 863
              + P   +  A       P     +RP    G+  P  +       PL  P    P  
Sbjct: 191 PPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSA 250

Query: 864 MHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLG------------GPGPGPGG 911
             RG P  P   + P P G++   PP     R    P LG               P P  
Sbjct: 251 --RGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSA 308

Query: 912 PEDRDGRQQPPQQPQQQPQ---------------PQAPQQPQQQQQQQPPPSQQPPPTQQ 956
           P        PP  P  Q                 P  P  P      Q PP+   PP Q 
Sbjct: 309 PPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQA 368

Query: 957 QP 958
            P
Sbjct: 369 PP 370



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 61/297 (20%), Positives = 100/297 (33%), Gaps = 61/297 (20%)

Query: 153 GSPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQQILQTFQQPP 212
           G P P       PPT+    SV +  +  +++   A  +  + + G  LQ          
Sbjct: 179 GLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARR--RPSAGGGLQ---------- 226

Query: 213 KPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPE 272
           +P S +L ++       +++  ++ P+     +A   P + K    + L         P 
Sbjct: 227 RPASRSLSSSATP----LSSPARSGPSARGTPRAPAHPSQPKPKGLQAL--------RPP 274

Query: 273 AVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAAS-PPPPQAPFGFPGDGMQQPA 331
            V   +K+   A+   + +    P+P+A    +A P+  + P PP  P       +  P 
Sbjct: 275 QVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPT 334

Query: 332 YTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLP--TPPFPPMAQPVIP---- 385
               Q    F P        P    +  PP    P   L P   PP PP + P+ P    
Sbjct: 335 L---QATHSFLP-------SPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATP 384

Query: 386 --------------------PTPPVQQPFQASFQAQNEPLTQKPHQQEMEVEQPCIQ 422
                               P+PPVQ PF         P    P Q    +  P +Q
Sbjct: 385 SPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQ 441


>gi|72004269 tetra-peptide repeat homeobox [Homo sapiens]
          Length = 411

 Score = 97.8 bits (242), Expect = 5e-20
 Identities = 88/264 (33%), Positives = 111/264 (42%), Gaps = 38/264 (14%)

Query: 655 VSPIPKPLPVPVP---PIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGF 711
           +SP P P+P P+P    IP P P ++P P   P Q   P+   +  P  + P+ IP P  
Sbjct: 92  LSPGPGPIPAPIPGPAQIPGPLPGSIPGPIPGPAQIPSPIPAPIPGP-ISGPVQIPGPFR 150

Query: 712 GPGVPPPPPPPPFLRPGFNPMHLP-PGFLPPGPPPPITPPVSIPPPHTPPISIPNLVSGA 770
           GP   P   P P   P   P   P PG +P   P PI  P+S P P   PIS+P  + G 
Sbjct: 151 GPIPGPISGPAPIPGPISGPFSGPNPGPIPGPNPGPIPGPISGPIPG--PISVP--IPGP 206

Query: 771 RGNAESGDSVKMYGSAVPPAAPTNLPTP-PVTQPVSLLGTQGVAPGPVIGLQAPSTGLLG 829
                SG          P + P   P P P+  P+S     G  PGP+ G       + G
Sbjct: 207 IPGPISG----------PISGPNPGPIPGPIPGPIS-----GPNPGPIPG------PISG 245

Query: 830 ARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPP 889
             PGLIP   P  +  P     P++ P P P  +   G   GPG    P      G  P 
Sbjct: 246 PNPGLIPGPIPGPISGPG----PIIGPIPSPAQIPGPGRLQGPGPILSPGRMRSPGSLPG 301

Query: 890 HGPFVRPGGMPGLG---GPGPGPG 910
             P + PG  PG G    P PGPG
Sbjct: 302 LAPILGPGSGPGSGSVPAPIPGPG 325



 Score = 94.4 bits (233), Expect = 6e-19
 Identities = 94/312 (30%), Positives = 120/312 (38%), Gaps = 59/312 (18%)

Query: 660 KPLPVPVPPIPVPAPITVP-PPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPP 718
           K +P  + P P P P  +P P Q+P   PG                 IP P  GP   P 
Sbjct: 86  KGIPAALSPGPGPIPAPIPGPAQIPGPLPG----------------SIPGPIPGPAQIPS 129

Query: 719 PPPPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGD 778
           P P P   P   P+ +P  F  P  P PI+ P  IP P + P S PN             
Sbjct: 130 PIPAPIPGPISGPVQIPGPFRGP-IPGPISGPAPIPGPISGPFSGPN------------- 175

Query: 779 SVKMYGSAVPPAAPTNLPTP---PVTQPVSLLGTQGVAPGPVIG-LQAPSTG-LLGARPG 833
                   +P   P  +P P   P+  P+S +   G  PGP+ G +  P+ G + G  PG
Sbjct: 176 -----PGPIPGPNPGPIPGPISGPIPGPIS-VPIPGPIPGPISGPISGPNPGPIPGPIPG 229

Query: 834 LIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGP--PPGPGGFAMPPPHGMKGPFP--P 889
            I    P  +P P     P + P P+P  +   GP   P P    +P P  ++GP P   
Sbjct: 230 PISGPNPGPIPGPISGPNPGLIPGPIPGPISGPGPIIGPIPSPAQIPGPGRLQGPGPILS 289

Query: 890 HGPFVRPGGMPGLG---GPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPP 946
            G    PG +PGL    GPG GPG              P   P P +   P     Q P 
Sbjct: 290 PGRMRSPGSLPGLAPILGPGSGPGS----------GSVPAPIPGPGSLPAPAPLWPQSPD 339

Query: 947 PSQQPPPTQQQP 958
            S   P TQ  P
Sbjct: 340 ASDFLPDTQLFP 351



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 58/206 (28%), Positives = 71/206 (34%), Gaps = 21/206 (10%)

Query: 764 PNLVSGARGN-AESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQA 822
           P  V G RG  A +   V    ++ P   P+ +   P  +P ++        GP    Q 
Sbjct: 30  PQRVPGQRGRGARAAPLVPAASASAPQRGPSGIL--PAAEP-TICSLHQAWGGPGCRAQK 86

Query: 823 PSTGLLGARPGLIPLQRP---------PGMPP---PHLQRFPLMPPRPMPPHMMHRGPPP 870
                L   PG IP   P         PG  P   P   + P   P P+P  +   GP  
Sbjct: 87  GIPAALSPGPGPIPAPIPGPAQIPGPLPGSIPGPIPGPAQIPSPIPAPIPGPIS--GPVQ 144

Query: 871 GPGGFAMPPPHGMKGPFPPHGPFVRP--GGMPG-LGGPGPGPGGPEDRDGRQQPPQQPQQ 927
            PG F  P P  + GP P  GP   P  G  PG + GP PGP           P   P  
Sbjct: 145 IPGPFRGPIPGPISGPAPIPGPISGPFSGPNPGPIPGPNPGPIPGPISGPIPGPISVPIP 204

Query: 928 QPQPQAPQQPQQQQQQQPPPSQQPPP 953
            P P     P       P P   P P
Sbjct: 205 GPIPGPISGPISGPNPGPIPGPIPGP 230


>gi|146134388 YLP motif containing 1 [Homo sapiens]
          Length = 2146

 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 107/364 (29%), Positives = 137/364 (37%), Gaps = 59/364 (16%)

Query: 654 PVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPG-------PPVVGALQPPAFTPPLGI 706
           P S +P PLP   PP+    P ++PPP +PP  P        PP V     P   PP G+
Sbjct: 522 PYSQMPPPLPTMPPPV---LPPSLPPPVMPPALPATVPPPGMPPPVMPPSLPTSVPPPGM 578

Query: 707 PPPGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGPPPPI---------TPPVSIPPPH 757
           PP     G PPP  PPP L     P  LPP  L    PPP+         TPP  IPPP 
Sbjct: 579 PPSLSSAG-PPPVLPPPSLSSAGPPPVLPPPSLSSTAPPPVMPLPPLSSATPPPGIPPPG 637

Query: 758 TPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNL---PTPPVTQPVSLLGTQGVAP 814
            P    P L +     A S  S ++     P   PT +     PP T    L   Q   P
Sbjct: 638 VPQGIPPQLTAAPVPPASSSQSSQVPEKPRPALLPTPVSFGSAPPTTYHPPL---QSAGP 694

Query: 815 GPVIGLQAPST------GLLGARPGLIPLQRPPGMPPPHLQRFPLMPP--RPMPPHMMHR 866
              +  +AP +          +  GL      P  P   ++  P+      P PP   + 
Sbjct: 695 SEQVNSKAPLSKSALPYSSFSSDQGLGESSAAPSQPITAVKDMPVRSGGLLPDPPRSSYL 754

Query: 867 GPPPGPGGFAMPP-----PHGMKGPFP---------PHGPFVRPGGMPGLGGP---GPGP 909
             P GP  F  P          +GP P         P GP  R  G P  G     G  P
Sbjct: 755 ESPRGP-RFDGPRRFEDLGSRCEGPRPKGPRFEGNRPDGPRPRYEGHPAEGTKSKWGMIP 813

Query: 910 GGPEDR----DGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQ-QPPPTQQQPQQFRND 964
            GP  +          P+  Q  PQ + P+    QQ QQ P SQ +P    ++P    + 
Sbjct: 814 RGPASQFYITPSTSLSPR--QSGPQWKGPKPAFGQQHQQQPKSQAEPLSGNKEPLADTSS 871

Query: 965 NRQQ 968
           N+Q+
Sbjct: 872 NQQK 875



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 81/297 (27%), Positives = 109/297 (36%), Gaps = 48/297 (16%)

Query: 732 MHLPPGFLP--------PGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMY 783
           M +PP F+P        P  PPP+ PP S+PPP  PP ++P  V              M 
Sbjct: 514 MSMPPPFVPYSQMPPPLPTMPPPVLPP-SLPPPVMPP-ALPATV----------PPPGMP 561

Query: 784 GSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGM 843
              +PP+ PT++P P +   +S  G   V P P +    P   L    P L     PP M
Sbjct: 562 PPVMPPSLPTSVPPPGMPPSLSSAGPPPVLPPPSLSSAGPPPVL--PPPSLSSTAPPPVM 619

Query: 844 PPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLG 903
           P P L      PP  +PP  + +G PP      +PP    +    P  P  RP  +P   
Sbjct: 620 PLPPLS--SATPPPGIPPPGVPQGIPPQLTAAPVPPASSSQSSQVPEKP--RPALLPTPV 675

Query: 904 GPGPGP----------GGPEDRDGRQQP------PQQPQQQPQ-----PQAPQQPQQQQQ 942
             G  P           GP ++   + P      P       Q       AP QP    +
Sbjct: 676 SFGSAPPTTYHPPLQSAGPSEQVNSKAPLSKSALPYSSFSSDQGLGESSAAPSQPITAVK 735

Query: 943 QQPPPSQQPPPTQQQPQQFRNDNRQQFNSGRDQERFGRRSFGNRVENDRERYGNRND 999
             P  S    P   +     +    +F+  R  E  G R  G R +  R   GNR D
Sbjct: 736 DMPVRSGGLLPDPPRSSYLESPRGPRFDGPRRFEDLGSRCEGPRPKGPRFE-GNRPD 791



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 92/369 (24%), Positives = 125/369 (33%), Gaps = 76/369 (20%)

Query: 654 PVSPIPKPLPVPVPPI-PVPAPITVPPPQVPP---------------------HQPGPPV 691
           P  P+P P PV +P   P P   +   P  P                      HQ     
Sbjct: 15  PPPPVPPPPPVALPEASPGPGYSSSTTPAAPSSSGFMSFREQHLAQLQQLQQMHQKQMQC 74

Query: 692 V---GALQPPAFTPPLGIPPPGFGPGVPPPPPPPP-----------------FLR----- 726
           V     L PP   PP  +P  G+G   PPPPP PP                  L      
Sbjct: 75  VLQPHHLPPPPLPPPPVMPGGGYGDWQPPPPPMPPPPGPALSYQKQQQYKHQMLHHQRDG 134

Query: 727 -PGFNPMHL-PPGFLPPGPPPPITPPVS--IPPPHTPPISIPNLVSGARGNAESGDSVKM 782
            PG  PM L  P   PP PP    PP    +PPP  PP   P        +       + 
Sbjct: 135 PPGLVPMELESPPESPPVPPGSYMPPSQSYMPPPQPPPSYYP-----PTSSQPYLPPAQP 189

Query: 783 YGSAVPPAAPTNLPTPPVTQPVS-----LLGTQGVAPGPVIGLQAPSTGLLGARPGLIPL 837
             S  PP+     PTP  +   S     L  +Q   P        PS G   ++    P 
Sbjct: 190 SPSQSPPSQSYLAPTPSYSSSSSSSQSYLSHSQSYLPSSQASPSRPSQGHSKSQLLAPP- 248

Query: 838 QRPPGMPPPH---LQRFPL-MPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPF 893
             PP  PP +   +Q+ PL    +          P P P    M P    +  +  H   
Sbjct: 249 --PPSAPPGNKTTVQQEPLESGAKNKSTEQQQAAPEPDPS--TMTPQEQQQYWYRQHLLS 304

Query: 894 VRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQPQQQP-QPQAPQQPQQQQQQQPPPSQQPP 952
           ++      L G   GP   +D     +P ++    P   Q P+ P  ++   PPP+++ P
Sbjct: 305 LQQRTKVHLPGHKKGPVVAKD---TPEPVKEEVTVPATSQVPESPSSEEPPLPPPNEEVP 361

Query: 953 P--TQQQPQ 959
           P    ++PQ
Sbjct: 362 PPLPPEEPQ 370



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 82/325 (25%), Positives = 99/325 (30%), Gaps = 94/325 (28%)

Query: 685 HQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGF--------------- 729
           H P PPV     PP   PP+ +P    GPG      P      GF               
Sbjct: 13  HYPPPPV-----PPP--PPVALPEASPGPGYSSSTTPAAPSSSGFMSFREQHLAQLQQLQ 65

Query: 730 -----------NPMHLPPGFLPPGPPPPITPPVSI-----PPPHTPPISIPNLVSGARGN 773
                       P HLPP   PP PPPP+ P         PPP  PP   P L S  +  
Sbjct: 66  QMHQKQMQCVLQPHHLPP---PPLPPPPVMPGGGYGDWQPPPPPMPPPPGPAL-SYQKQQ 121

Query: 774 AESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPG 833
                 +       P   P  L +PP + PV         PG  +    PS   +     
Sbjct: 122 QYKHQMLHHQRDGPPGLVPMELESPPESPPVP--------PGSYM---PPSQSYM----- 165

Query: 834 LIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPF 893
                 PP  PPP        PP    P++    PP  P     PP      P P +   
Sbjct: 166 ------PPPQPPPSYY-----PPTSSQPYL----PPAQPSPSQSPPSQSYLAPTPSYSSS 210

Query: 894 VRPG------GMPGLGGPGPGPGGPEDRDGRQQ-----PPQQP-------QQQPQPQAPQ 935
                         L      P  P     + Q     PP  P       QQ+P     +
Sbjct: 211 SSSSQSYLSHSQSYLPSSQASPSRPSQGHSKSQLLAPPPPSAPPGNKTTVQQEPLESGAK 270

Query: 936 QPQQQQQQ---QPPPSQQPPPTQQQ 957
               +QQQ   +P PS   P  QQQ
Sbjct: 271 NKSTEQQQAAPEPDPSTMTPQEQQQ 295



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 75/277 (27%), Positives = 106/277 (38%), Gaps = 56/277 (20%)

Query: 830  ARPGLIPLQRPPGM--PPPHLQRFPLMPPRPMPPHMMHRGP---PPGPGGFAMPPPHGMK 884
            +RPG+ P   PPG   PPP + + P    RP  P      P   PP P     PPP    
Sbjct: 1501 SRPGMYP---PPGSYRPPPPMGKPPGSIVRPSAPPARSSVPVTRPPVPIPPPPPPP---- 1553

Query: 885  GPFPPHGPFVRP------------GGMPGLGGPGPGPG-GPEDRDGRQQPPQQPQQQPQP 931
             P PP  P ++P                GL       G   E +      P  P   P P
Sbjct: 1554 -PLPPPPPVIKPQTSAVEQERWDEDSFYGLWDTNDEQGLNSEFKSETAAIPSAPVLPPPP 1612

Query: 932  -QAPQQPQQQQQQQPPPSQQPPPTQQ-----QPQQFRNDNRQQFNSGR------------ 973
              +   P        PP  +PPP QQ       +    +  +Q   G             
Sbjct: 1613 VHSSIPPPGPVPMGMPPMSKPPPVQQTVDYGHGRDISTNKVEQIPYGERITLRPDPLPER 1672

Query: 974  ---DQERFGRRSFGNRVENDRERYGNRNDDRDNSNRDRREWGRRSPDRDRHRDLEERNRR 1030
               + E  G+R   +R E DRE Y +R   + N   D R++ R   DR+ HRD  +R+R 
Sbjct: 1673 STFETEHAGQRDRYDR-ERDREPYFDR---QSNVIADHRDFKR---DRETHRD-RDRDRG 1724

Query: 1031 SSGHRDRERDSRDRESRREKEEARGKEKPEVTDRAGG 1067
               + DR+R  R+R  R ++ ++   +K   + R GG
Sbjct: 1725 VIDY-DRDRFDRERRPRDDRAQSYRDKKDHSSSRRGG 1760



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 88/337 (26%), Positives = 118/337 (35%), Gaps = 80/337 (23%)

Query: 726  RPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMYGS 785
            RPG  P   PPG   P PPP   PP SI  P  PP                        S
Sbjct: 1502 RPGMYP---PPGSYRP-PPPMGKPPGSIVRPSAPPAR----------------------S 1535

Query: 786  AVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARP-------GLIPLQ 838
            +VP   P  +P PP   P  L       P PVI    P T  +           GL    
Sbjct: 1536 SVPVTRPP-VPIPPPPPPPPL-----PPPPPVI---KPQTSAVEQERWDEDSFYGLWDTN 1586

Query: 839  RPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGG 898
               G+          +P  P+ P                PPP  +    PP GP   P G
Sbjct: 1587 DEQGLNSEFKSETAAIPSAPVLP----------------PPP--VHSSIPPPGPV--PMG 1626

Query: 899  MPGLGGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQP 958
            MP +  P P     +   GR     + +Q P  +     +   +  P P +    T+   
Sbjct: 1627 MPPMSKPPPVQQTVDYGHGRDISTNKVEQIPYGE-----RITLRPDPLPERSTFETEHAG 1681

Query: 959  QQFRNDNRQQFNSGRDQERFGRRSFG-----NRVENDRERYGNRNDDRDNSNRDRREWGR 1013
            Q+ R D        RD+E +  R           + DRE + +R+ DR   + DR  + R
Sbjct: 1682 QRDRYDRE------RDREPYFDRQSNVIADHRDFKRDRETHRDRDRDRGVIDYDRDRFDR 1735

Query: 1014 -RSPDRDRHRDLEERNRRSSGHRDR-ERDSRDRESRR 1048
             R P  DR +   ++   SS  R   +R S DR+S R
Sbjct: 1736 ERRPRDDRAQSYRDKKDHSSSRRGGFDRPSYDRKSDR 1772



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 69/279 (24%), Positives = 92/279 (32%), Gaps = 49/279 (17%)

Query: 716 PPPPPPPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAE 775
           PPPP PPP           PP  LP   P P     + P     P S   +    +  A+
Sbjct: 15  PPPPVPPP-----------PPVALPEASPGPGYSSSTTP---AAPSSSGFMSFREQHLAQ 60

Query: 776 SGDSVKMYGSAVP-PAAPTNLPTPPVTQPVSLLG-----------TQGVAPGPVIGLQAP 823
                +M+   +     P +LP PP+  P  + G                PGP +  Q  
Sbjct: 61  LQQLQQMHQKQMQCVLQPHHLPPPPLPPPPVMPGGGYGDWQPPPPPMPPPPGPALSYQKQ 120

Query: 824 STGLLGARPGLIPLQR--PPGMPPPHLQRFPLMPPRP----MPPHMMHRGPPPGPGGFAM 877
                  +  ++  QR  PPG+ P  L+  P  PP P    MPP   +  PP  P  +  
Sbjct: 121 QQ----YKHQMLHHQRDGPPGLVPMELESPPESPPVPPGSYMPPSQSYMPPPQPPPSYY- 175

Query: 878 PPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQ-----QPPQQPQQQPQPQ 932
            PP   +   PP  P       P      P P         Q          P  Q  P 
Sbjct: 176 -PPTSSQPYLPPAQPSPSQ-SPPSQSYLAPTPSYSSSSSSSQSYLSHSQSYLPSSQASPS 233

Query: 933 APQQPQQQQQQQPPPSQQPPP-----TQQQPQQFRNDNR 966
            P Q   + Q   PP    PP      QQ+P +    N+
Sbjct: 234 RPSQGHSKSQLLAPPPPSAPPGNKTTVQQEPLESGAKNK 272



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 38/131 (29%), Positives = 47/131 (35%), Gaps = 1/131 (0%)

Query: 290 PAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQ 349
           P    PP P A   A+  P  +S   P AP        ++    Q Q + Q   + M   
Sbjct: 16  PPPVPPPPPVALPEASPGPGYSSSTTPAAPSSSGFMSFREQHLAQLQQLQQMHQKQMQCV 75

Query: 350 QDPMH-HQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQK 408
             P H    PLPP   MPG G     P PP   P   P    Q+  Q   Q  +      
Sbjct: 76  LQPHHLPPPPLPPPPVMPGGGYGDWQPPPPPMPPPPGPALSYQKQQQYKHQMLHHQRDGP 135

Query: 409 PHQQEMEVEQP 419
           P    ME+E P
Sbjct: 136 PGLVPMELESP 146



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 76/299 (25%), Positives = 104/299 (34%), Gaps = 54/299 (18%)

Query: 143 PVAENVTNNEGSPPPPVKVSSEPP-----TQATPNSVPAVPQL--PSSDA-----FAAVA 190
           PV E VT    S  P    S EPP      +  P   P  PQ   P  DA      AA A
Sbjct: 329 PVKEEVTVPATSQVPESPSSEEPPLPPPNEEVPPPLPPEEPQSEDPEEDARLKQLQAAAA 388

Query: 191 QLFQTTQGQ-------------QLQQILQTFQQ----PPKPQSPALDNAV------MAQV 227
              Q  Q +             QLQQILQ +QQ    PP  Q+ ++D  +        Q 
Sbjct: 389 HWQQHQQHRVGFQYQGIMQKHTQLQQILQQYQQIIQPPPHIQTMSVDMQLRHYEMQQQQF 448

Query: 228 QAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAV-- 285
           Q +  + +       EQ  ++P  +Q   ++K+      +    +A +   +E   +   
Sbjct: 449 QHLYQEWEREFQLWEEQLHSYPHKDQLQEYEKQWK---TWQGHMKATQSYLQEKVNSFQN 505

Query: 286 -------TTTAPAAAVP----PAPTATVPAAAAPAAASPP--PPQAPFGFPGDGMQQPAY 332
                    + P   VP    P P  T+P    P +  PP  PP  P   P  GM  P  
Sbjct: 506 MKNQYMGNMSMPPPFVPYSQMPPPLPTMPPPVLPPSLPPPVMPPALPATVPPPGMPPPVM 565

Query: 333 TQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPG-FGLLPTPPFPPMAQPVIPPTPPV 390
                     P M           V  PP+    G   +LP P     A P + P PP+
Sbjct: 566 PPSLPTSVPPPGMPPSLSSAGPPPVLPPPSLSSAGPPPVLPPPSLSSTAPPPVMPLPPL 624



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 46/172 (26%), Positives = 62/172 (36%), Gaps = 58/172 (33%)

Query: 629  DWKGIPKKPENEVAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPG 688
            D+   P+  ++   Q    + + + P    P     P PP+  P P ++  P  PP +  
Sbjct: 1478 DFGSEPQMADHLPPQESRLQNTSSRPGMYPPPGSYRPPPPMGKP-PGSIVRPSAPPARSS 1536

Query: 689  PPVVGALQPPAFTPPLGIPPPGFGPGVPPP--PPPPPFLRP------------------- 727
             PV          PP+ IPPP      PPP  PPPPP ++P                   
Sbjct: 1537 VPVT--------RPPVPIPPPP-----PPPPLPPPPPVIKPQTSAVEQERWDEDSFYGLW 1583

Query: 728  ------GFN-------------PMHLPP----GFLPPGPPPPITPPVSIPPP 756
                  G N             P+  PP       PPGP P   PP+S PPP
Sbjct: 1584 DTNDEQGLNSEFKSETAAIPSAPVLPPPPVHSSIPPPGPVPMGMPPMSKPPP 1635



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 53/189 (28%), Positives = 67/189 (35%), Gaps = 51/189 (26%)

Query: 680  PQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHLP-PGF 738
            PQ+  H P  P    LQ  +  P +  PP  + P  P   PP   +RP   P     P  
Sbjct: 1483 PQMADHLP--PQESRLQNTSSRPGMYPPPGSYRPPPPMGKPPGSIVRPSAPPARSSVPVT 1540

Query: 739  LPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMYG-------------- 784
             PP P PP  PP  + PP  PP+  P     +    E  D    YG              
Sbjct: 1541 RPPVPIPPPPPPPPL-PP-PPPVIKPQT---SAVEQERWDEDSFYGLWDTNDEQGLNSEF 1595

Query: 785  ---SAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPP 841
               +A  P+AP  LP PPV   +         PGPV                  P+  PP
Sbjct: 1596 KSETAAIPSAPV-LPPPPVHSSIP-------PPGPV------------------PMGMPP 1629

Query: 842  GMPPPHLQR 850
               PP +Q+
Sbjct: 1630 MSKPPPVQQ 1638



 Score = 43.9 bits (102), Expect = 9e-04
 Identities = 65/286 (22%), Positives = 92/286 (32%), Gaps = 44/286 (15%)

Query: 155 PPPPVKVSSEPPTQATPNSVPA-------VPQLPSSDAFAA-----VAQLFQTTQ--GQQ 200
           PPPPV     PP  A P + P         P  PSS  F +     +AQL Q  Q   +Q
Sbjct: 15  PPPPVP---PPPPVALPEASPGPGYSSSTTPAAPSSSGFMSFREQHLAQLQQLQQMHQKQ 71

Query: 201 LQQILQTFQ--QPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFD 258
           +Q +LQ      PP P  P +        Q         P  P       PPP    ++ 
Sbjct: 72  MQCVLQPHHLPPPPLPPPPVMPGGGYGDWQ------PPPPPMP-------PPPGPALSYQ 118

Query: 259 KKLLDRFD----YDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASP- 313
           K+   +        D P  +   + E         P + +PP+ +   P    P+   P 
Sbjct: 119 KQQQYKHQMLHHQRDGPPGLVPMELESPPESPPVPPGSYMPPSQSYMPPPQPPPSYYPPT 178

Query: 314 -PPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLP 372
              P  P   P      P+ +       +       Q    H Q  LP +   P      
Sbjct: 179 SSQPYLPPAQPSPSQSPPSQSYLAPTPSYSSSSSSSQSYLSHSQSYLPSSQASPS----- 233

Query: 373 TPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEMEVEQ 418
            P        ++ P PP   P   +   Q EPL      +  E +Q
Sbjct: 234 RPSQGHSKSQLLAPPPPSAPPGNKT-TVQQEPLESGAKNKSTEQQQ 278



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 61/301 (20%), Positives = 104/301 (34%), Gaps = 89/301 (29%)

Query: 155 PPPPVKVSSEPPTQATPNSVPAVP---QLPSSDAFAAVAQLFQTTQGQQLQQILQTFQQP 211
           PPP    S  PPT + P   PA P   Q P S ++ A                      P
Sbjct: 166 PPPQPPPSYYPPTSSQPYLPPAQPSPSQSPPSQSYLAPT--------------------P 205

Query: 212 PKPQSPALDNAVMAQVQAITAQLKTTPTQPSE----QKAAFPPPEQKTAFDKKLLDRFDY 267
               S +   + ++  Q+     + +P++PS+     +   PPP      +K  + +   
Sbjct: 206 SYSSSSSSSQSYLSHSQSYLPSSQASPSRPSQGHSKSQLLAPPPPSAPPGNKTTVQQ--- 262

Query: 268 DDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGM 327
               E +E   K  +T     AP     P P+   P                        
Sbjct: 263 ----EPLESGAKNKSTEQQQAAPE----PDPSTMTP-----------------------Q 291

Query: 328 QQPAYTQHQNMDQFQPR----MMGIQQ---------DPMHHQVPLPPNGQMPGFGLLPTP 374
           +Q  Y   Q++   Q R    + G ++         +P+  +V +P   Q+P       P
Sbjct: 292 EQQQYWYRQHLLSLQQRTKVHLPGHKKGPVVAKDTPEPVKEEVTVPATSQVPESPSSEEP 351

Query: 375 PFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEMEVEQPCIQEVKRHMSDNRKS 434
           P PP  + V PP PP             EP ++ P +++  ++Q  +Q    H   +++ 
Sbjct: 352 PLPPPNEEVPPPLPP------------EEPQSEDP-EEDARLKQ--LQAAAAHWQQHQQH 396

Query: 435 R 435
           R
Sbjct: 397 R 397



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 38/164 (23%), Positives = 59/164 (35%), Gaps = 14/164 (8%)

Query: 290 PAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQ---PRMM 346
           P   +PP P   +P         PPPP  P   P    Q+    +HQ +   +   P ++
Sbjct: 82  PPPPLPPPPV--MPGGGYGDWQPPPPPMPPPPGPALSYQKQQQYKHQMLHHQRDGPPGLV 139

Query: 347 GIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPP-------MAQPVIPPT--PPVQQPFQAS 397
            ++ +      P+PP   MP       PP PP        +QP +PP    P Q P   S
Sbjct: 140 PMELESPPESPPVPPGSYMPPSQSYMPPPQPPPSYYPPTSSQPYLPPAQPSPSQSPPSQS 199

Query: 398 FQAQNEPLTQKPHQQEMEVEQPCIQEVKRHMSDNRKSRSRSASR 441
           + A     +      +  +            S +R S+  S S+
Sbjct: 200 YLAPTPSYSSSSSSSQSYLSHSQSYLPSSQASPSRPSQGHSKSQ 243



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 54/226 (23%), Positives = 81/226 (35%), Gaps = 40/226 (17%)

Query: 295  PPAPTA--TVPAAAAPAAASPPPPQAPFGFPGDGMQ-QPAYTQHQNMDQ----------- 340
            P AP A  +VP    P    PPPP  P   P   ++ Q +  + +  D+           
Sbjct: 1528 PSAPPARSSVPVTRPPVPIPPPPPPPPLPPPPPVIKPQTSAVEQERWDEDSFYGLWDTND 1587

Query: 341  -------FQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQ- 392
                   F+     I   P+     LPP    P    +P P   PM  P +   PPVQQ 
Sbjct: 1588 EQGLNSEFKSETAAIPSAPV-----LPPP---PVHSSIPPPGPVPMGMPPMSKPPPVQQT 1639

Query: 393  -PFQASFQAQNEPLTQKPHQQEMEVEQPCIQEVKRHMSDNRKSRSRSASRSPKRRRSRSG 451
              +          + Q P+ + + +    + E     +++   R R       R R R  
Sbjct: 1640 VDYGHGRDISTNKVEQIPYGERITLRPDPLPERSTFETEHAGQRDRY-----DRERDREP 1694

Query: 452  SRSRRSR---HRRSRSRSRDRRRHSPRSRSQERRDREK-ERERRQK 493
               R+S      R   R R+  R   R R     DR++ +RERR +
Sbjct: 1695 YFDRQSNVIADHRDFKRDRETHRDRDRDRGVIDYDRDRFDRERRPR 1740



 Score = 37.4 bits (85), Expect = 0.081
 Identities = 74/350 (21%), Positives = 113/350 (32%), Gaps = 81/350 (23%)

Query: 146  ENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQQIL 205
            +N ++  G  PPP      PP    P S+   P  P + +   V +              
Sbjct: 1497 QNTSSRPGMYPPPGSYRPPPPMGKPPGSIVR-PSAPPARSSVPVTR-------------- 1541

Query: 206  QTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRF 265
                 PP P  P L                  P  P   K      EQ+   +      +
Sbjct: 1542 PPVPIPPPPPPPPL------------------PPPPPVIKPQTSAVEQERWDEDSFYGLW 1583

Query: 266  DYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGD 325
            D +DE     E K E  TA   +AP    PP  ++            PPP   P G P  
Sbjct: 1584 DTNDEQGLNSEFKSE--TAAIPSAPVLPPPPVHSSI-----------PPPGPVPMGMP-- 1628

Query: 326  GMQQPAYTQHQNMDQFQPRMMG---IQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQP 382
             M +P   Q Q +D    R +    ++Q P   ++ L P+               P+   
Sbjct: 1629 PMSKPPPVQ-QTVDYGHGRDISTNKVEQIPYGERITLRPD---------------PL--- 1669

Query: 383  VIPPTPPVQQPFQASFQAQNEPL-TQKPHQQEMEVEQPCIQEVKRHMSDNRKSRSRSASR 441
                  P +  F+     Q +    ++  +   + +   I + +    D    R R   R
Sbjct: 1670 ------PERSTFETEHAGQRDRYDRERDREPYFDRQSNVIADHRDFKRDRETHRDRDRDR 1723

Query: 442  SPKRRRSRSGSRSRRSRHRRSRSRSRDRRRHSPRSRSQERR---DREKER 488
                       R RR R  R++S  RD++ HS   R    R   DR+ +R
Sbjct: 1724 GVIDYDRDRFDRERRPRDDRAQS-YRDKKDHSSSRRGGFDRPSYDRKSDR 1772



 Score = 35.8 bits (81), Expect = 0.23
 Identities = 53/212 (25%), Positives = 84/212 (39%), Gaps = 35/212 (16%)

Query: 868  PPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRD-----GRQQPP 922
            P PG GG  M P H  +   PP  P+           P  G   P +R+      R++  
Sbjct: 1171 PEPGDGGEKMYPYHRDE---PPRAPWNHGEERGHEEFPLDGRNAPMERERLDDWDRERYW 1227

Query: 923  QQPQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQP--------QQFRND-NRQ-QFNSG 972
            ++ ++  Q    +   ++ +   PPS+     ++ P        Q    D NR+ + +  
Sbjct: 1228 RECERDYQDDTLELYNREDRFSAPPSRSHDGDRRGPWWDDWERDQDMDEDYNREMERDMD 1287

Query: 973  RDQERFGR------RSFGNRVENDRERYGNRNDDRDNSNRDRREWGRRS-------PDRD 1019
            RD +R  R      RS  N  + D   YG   D++++  R+R              P  D
Sbjct: 1288 RDVDRISRPMDMYDRSLDNEWDRD---YGRPLDEQESQFRERDIPSLPPLPPLPPLPPLD 1344

Query: 1020 RHRDLEERNRRSSGHRDRERDSRDRESRREKE 1051
            R+RD   R  R+  H   +RD RDR   R +E
Sbjct: 1345 RYRDDRWREERNREH-GYDRDFRDRGELRIRE 1375



 Score = 33.9 bits (76), Expect = 0.89
 Identities = 51/201 (25%), Positives = 76/201 (37%), Gaps = 46/201 (22%)

Query: 854  MPPRPMPPHMMHRGPPPGPG----GFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGP 909
            +PPR        RGPP GPG    G         +GPF P          PG GG    P
Sbjct: 1134 IPPRRAGSR--ERGPPRGPGSRERGLGRSDFGRDRGPFRPE---------PGDGGEKMYP 1182

Query: 910  GGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQPQQFRNDNRQQF 969
                    R +PP+ P    +       ++  ++ P   +  P  +++   +        
Sbjct: 1183 ------YHRDEPPRAPWNHGE-------ERGHEEFPLDGRNAPMERERLDDW-------- 1221

Query: 970  NSGRDQERFGRRSFGNRVENDRERYGNRNDDRDNSNRDRREWGRRSP---DRDRHRDLEE 1026
                D+ER+ R    +  ++  E Y NR D          +  RR P   D +R +D++E
Sbjct: 1222 ----DRERYWRECERDYQDDTLELY-NREDRFSAPPSRSHDGDRRGPWWDDWERDQDMDE 1276

Query: 1027 RNRRSSGHRDRERDSRDRESR 1047
               R    RD +RD  DR SR
Sbjct: 1277 DYNREM-ERDMDRDV-DRISR 1295



 Score = 33.5 bits (75), Expect = 1.2
 Identities = 31/130 (23%), Positives = 47/130 (36%), Gaps = 45/130 (34%)

Query: 266  DYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGD 325
            D+  EP+  +    +++    T++     PP           P +  PPPP    G P  
Sbjct: 1478 DFGSEPQMADHLPPQESRLQNTSSRPGMYPP-----------PGSYRPPPPM---GKPPG 1523

Query: 326  GMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPL--PPNGQMPGFGLLPTPPFPPMAQPV 383
             + +P+                    P    VP+  PP         +P PP PP   P 
Sbjct: 1524 SIVRPS------------------APPARSSVPVTRPP---------VPIPPPPP--PPP 1554

Query: 384  IPPTPPVQQP 393
            +PP PPV +P
Sbjct: 1555 LPPPPPVIKP 1564



 Score = 32.7 bits (73), Expect = 2.0
 Identities = 28/90 (31%), Positives = 30/90 (33%), Gaps = 17/90 (18%)

Query: 873 GGFAMPPP----HGMKGPFPPHGPFVRPGGM------PGLGGPGPGPGGPEDRDGRQQPP 922
           G  +MPPP      M  P P   P V P  +      P L    P PG P        PP
Sbjct: 512 GNMSMPPPFVPYSQMPPPLPTMPPPVLPPSLPPPVMPPALPATVPPPGMPPP----VMPP 567

Query: 923 QQPQQQPQPQAPQQPQQQQQQQPPPSQQPP 952
             P   P    P  P       PPP   PP
Sbjct: 568 SLPTSVP---PPGMPPSLSSAGPPPVLPPP 594


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 96/344 (27%), Positives = 119/344 (34%), Gaps = 73/344 (21%)

Query: 656 SPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPP------LG---- 705
           S  P  LP       +   +  P P  PP    PP +  L  P  TPP      LG    
Sbjct: 315 SQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTL 374

Query: 706 ------IPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGPP--PPITPPVSIPPPH 757
                 +P P   P   PPP  PP L        LPP   PP PP  PP++ P++ P P 
Sbjct: 375 QATHSFLPSPPLSPLATPPPQAPPALA-------LPPLQAPPSPPASPPLS-PLATPSPQ 426

Query: 758 TPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPV 817
            P     +L+                     P +P   P+PPV  P S   +  V+P   
Sbjct: 427 APNALAVHLLQA-------------------PFSPP--PSPPVQAPFSPPASPPVSPSAT 465

Query: 818 IGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFP---LMPPRPMPPHMMHRGPPPGPGG 874
              QAP +  L A P  +P   PP  PP      P     PP   PP  + + PP  P  
Sbjct: 466 PPSQAPPS--LAAPPLQVP-PSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPA 522

Query: 875 FAMPPPHGMKGP---FPPHGPFVRPGGMPGLGGPGPGPGGPEDRDG-RQQPPQQPQQQPQ 930
            A PP   +  P   FP   PF     +P      P P  P        Q P  P   P 
Sbjct: 523 LATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPT 582

Query: 931 PQAPQQPQQQQQQ----------------QPPPSQQPPPTQQQP 958
            QAP++P                       PPPS+ P  T   P
Sbjct: 583 LQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGP 626



 Score = 90.5 bits (223), Expect = 8e-18
 Identities = 96/360 (26%), Positives = 125/360 (34%), Gaps = 61/360 (16%)

Query: 634 PKKPENEVAQNGGAETSH-TEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPVV 692
           P  P ++   + G+ T   T    P P   P+  PP   P  + +PP Q PP  P  P +
Sbjct: 358 PATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPL 417

Query: 693 GALQPPAFTPPLGI----------PPPGFGPGVPPPPPPPPFLRPGFNP-------MHLP 735
             L  P+   P  +          PPP      P  PP  P + P   P       +  P
Sbjct: 418 SPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAP 477

Query: 736 PGFLPPGPP--PPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPT 793
           P  +PP PP  PP++P  + PP   PP++ P L                  +  PP AP 
Sbjct: 478 PLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQL----------------AKPPPQAPP 521

Query: 794 NLPTPPV----TQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIP--LQRPPGMPPPH 847
            L TPP+    + P S  G    +P   + +   +T    A P L    LQ PP  P   
Sbjct: 522 ALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASP 581

Query: 848 LQRFPLMPPRPMPPHMMHRGP------PPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPG 901
             + P  PP P P   +  GP       PGP     PPP          GP +       
Sbjct: 582 TLQAPRRPPTPGPDTSV-SGPRLTLALAPGP-----PPPPSRSPSSTLSGPDLAGHSSSA 635

Query: 902 LGGPGPGPG---GPEDRDGRQQPPQQPQQQPQPQA----PQQPQQQQQQQPPPSQQPPPT 954
              P    G   GPE       PP        P A    P  P   +     P   PP T
Sbjct: 636 TSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPAT 695



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 85/280 (30%), Positives = 101/280 (36%), Gaps = 44/280 (15%)

Query: 654 PVSPIPKP--LPVPVPPIPVPAPITVPPPQVPPHQPGPPVV--GALQPPAFTPPLGIPPP 709
           P SP   P   P   PP   P  +  PP QVPP  P  P +   A  PP   PPL  PP 
Sbjct: 451 PFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPL 510

Query: 710 GFGPGVPPPPPPPPFLRPGFNPMHLPPGFLP---PGPPPPITP--PVSIPPPHTPPISIP 764
                 PPP  PP    P    +  PP   P   P  P    P  P++ PPP  PP+   
Sbjct: 511 QLAK--PPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAA 568

Query: 765 NLVSGARGNAESGDSVKMYGSAVPPAAPT-----NLPTP-PVTQPVSLLGTQGVAPG-PV 817
            L+                    PPA+PT       PTP P T       T  +APG P 
Sbjct: 569 PLLQVPPS---------------PPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPP 613

Query: 818 IGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAM 877
              ++PS+ L G  P L          P  L+ +   P            PPP     A 
Sbjct: 614 PPSRSPSSTLSG--PDLAGHSSSATSTPEELRGYDSGPEGGAA-----ASPPPDAELAAC 666

Query: 878 PPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDG 917
            P    +GP PP    +   G PG   P P   GP   DG
Sbjct: 667 HPAAWSRGPAPP----LAFRGAPGAPLPWPPATGPGSADG 702



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 77/292 (26%), Positives = 106/292 (36%), Gaps = 45/292 (15%)

Query: 131 LLDMAAGTSNAAPVAENVTNNEGSPPPPVKVS-SEPPTQATPNSVPAVPQLPSSDAFAAV 189
           L   A  T  A P + ++T    +P P    S S PP+  T  S PA P  PS    +  
Sbjct: 313 LQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATP--PSQATTSLG 370

Query: 190 AQLFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFP 249
           +   Q T        L     PP    PAL    +  +QA  +   + P  P     A P
Sbjct: 371 SPTLQATHSFLPSPPLSPLATPPPQAPPAL---ALPPLQAPPSPPASPPLSP----LATP 423

Query: 250 PPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPA 309
            P+   A    LL    +   P    ++           +P A+ P +P+AT P+ A P+
Sbjct: 424 SPQAPNALAVHLLQA-PFSPPPSPPVQAP---------FSPPASPPVSPSATPPSQAPPS 473

Query: 310 AASPP----------PPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPL 359
            A+PP          PP +P   P      P       + +  P+       P    +P 
Sbjct: 474 LAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPS 533

Query: 360 PP---NGQMP--GFGLLPTPPF---PPMAQPV-------IPPTPPVQQPFQA 396
           PP    GQ P      LP  P    PP A PV       +PP+PP     QA
Sbjct: 534 PPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQA 585



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 74/274 (27%), Positives = 93/274 (33%), Gaps = 54/274 (19%)

Query: 633 IPKKPENEVAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGP-PV 691
           +P  P      +  A      P      PL +  PP   P  +  PP Q  P  P   P 
Sbjct: 481 VPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPG 540

Query: 692 VGALQPPAFTP--PLGIPPPGFGP-------GVPPPPPPPPFLRPGFNPMHLPPG----- 737
                P A  P  PL  PPP   P        VPP PP  P L+    P    P      
Sbjct: 541 QAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSG 600

Query: 738 -----FLPPGPPPP--ITPPVSIPPPH---------TPPISIPNLVSGARGNAESGDSVK 781
                 L PGPPPP   +P  ++  P          + P  +    SG  G A +     
Sbjct: 601 PRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPD 660

Query: 782 MYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPP 841
              +A  PAA +  P P    P++  G  G AP P      P+TG  G+  GL  +    
Sbjct: 661 AELAACHPAAWSRGPAP----PLAFRGAPG-APLP----WPPATG-PGSADGLCTIYETE 710

Query: 842 GMPPPHLQRFPLMPPRPMP-PHMMHRGPPPGPGG 874
           G            P    P P  +  GP PG  G
Sbjct: 711 G------------PESATPAPGALDPGPSPGTSG 732



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 64/261 (24%), Positives = 82/261 (31%), Gaps = 31/261 (11%)

Query: 154 SPP--PPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQQILQTFQQP 211
           SPP  PPV  S+ PP+QA P+      Q+P S   +       T   Q    +     Q 
Sbjct: 453 SPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQL 512

Query: 212 PKPQSPALDNAVMAQVQAITAQLKTTPTQ----PSEQ----KAAFPPPEQKTAFDKKLLD 263
            KP   A        +QA+ +   + P Q    PS        A PPP+        LL 
Sbjct: 513 AKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQ 572

Query: 264 RFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFP 323
                  P A          + T  AP     P P  +V       A +P PP  P   P
Sbjct: 573 ---VPPSPPA----------SPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSP 619

Query: 324 GDGMQQPAYTQHQNMDQFQP-RMMGIQQDPMHHQVPLPPNG------QMPGFGLLPTPPF 376
              +  P    H +     P  + G    P       PP            +   P PP 
Sbjct: 620 SSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPL 679

Query: 377 PPMAQPVIP-PTPPVQQPFQA 396
                P  P P PP   P  A
Sbjct: 680 AFRGAPGAPLPWPPATGPGSA 700



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 68/303 (22%), Positives = 102/303 (33%), Gaps = 46/303 (15%)

Query: 138 TSNAAPV---AENVTNNEGSPPPPVKVSSEPPTQATPNSVPAV--PQL--PSSDAFAAVA 190
           +S+A P+   A +  +  G+P  P       P+Q  P  + A+  PQ+  P  DA  A+ 
Sbjct: 243 SSSATPLSSPARSGPSARGTPRAPAH-----PSQPKPKGLQALRPPQVTPPRKDAAPALG 297

Query: 191 QLFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPP 250
            L  +             Q PP   +    +++  Q+         +P+ P   +    P
Sbjct: 298 PLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSP 357

Query: 251 PEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAA 310
           P                   P +   +     T   T +   + P +P AT P  A PA 
Sbjct: 358 PAT-----------------PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPAL 400

Query: 311 ASPP---PPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPG 367
           A PP   PP  P   P   +  P+           P  + +         P  P  Q P 
Sbjct: 401 ALPPLQAPPSPPASPPLSPLATPSPQA--------PNALAVHLLQAPFSPPPSPPVQAP- 451

Query: 368 FGLLPTPPFPPMAQPV--IPPT---PPVQQPFQASFQAQNEPLTQKPHQQEMEVEQPCIQ 422
           F    +PP  P A P    PP+   PP+Q P          P    P Q    +  P +Q
Sbjct: 452 FSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQ 511

Query: 423 EVK 425
             K
Sbjct: 512 LAK 514



 Score = 37.0 bits (84), Expect = 0.11
 Identities = 86/356 (24%), Positives = 102/356 (28%), Gaps = 98/356 (27%)

Query: 694 ALQPPAFTPPLGIPPPGFGPGVPPPPPP--PPFLR-----------------PGFNPMHL 734
           A  P A  P L  P P   PG P PPPP  P  LR                  G     +
Sbjct: 14  ARTPAARAPGLLTPRP---PGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATI 70

Query: 735 PPGFLPPGPP---------PPITPPVS-----IPPPHTP---PISIPNLVSG-------- 769
           P      GP          P   PP S      PP       P+S P   SG        
Sbjct: 71  PESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLG 130

Query: 770 ------------ARGNAESGD--SVKMYGSAVPPAAPT-NLPTPPVTQPVSLLGTQGVAP 814
                       ARG A      S    G+    + PT   P+P + +     GT+   P
Sbjct: 131 QKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLP 190

Query: 815 GPVIG------LQAPSTGLLGA------RPGLIPLQRPP---GMPPPHLQRF-----PLM 854
            P          + P   +  A       P     +RP    G+  P  +       PL 
Sbjct: 191 RPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLS 250

Query: 855 PPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGP---GG 911
            P    P    RG P  P   + P P G++   PP     R    P LG     P     
Sbjct: 251 SPARSGPSA--RGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPS 308

Query: 912 PEDRDGRQQPPQQPQ-----------QQPQPQAPQQPQQQQQQQPPPSQQPPPTQQ 956
           P      Q PP  P              P P AP  P      Q  PS    P  Q
Sbjct: 309 PSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQ 364


>gi|5032069 splicing factor 3b, subunit 4 [Homo sapiens]
          Length = 424

 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 91/247 (36%), Positives = 106/247 (42%), Gaps = 53/247 (21%)

Query: 684 PHQ---PGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLP 740
           PHQ     PP   A  P   +   G+PPPG  P    PPP PP       P  LPPG  P
Sbjct: 207 PHQLFADAPPPPSAPNPVVSSLGSGLPPPGMPPPGSFPPPVPP-------PGALPPGIPP 259

Query: 741 PGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMYGSAVP-PAAPTNLPTPP 799
             PPPP+ P  +    H PP +      G  G    G     +G + P P  P  +P P 
Sbjct: 260 AMPPPPMPPGAA---GHGPPSA------GTPGAGHPG-----HGHSHPHPFPPGGMPHPG 305

Query: 800 VTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMP---------PPHLQR 850
           ++Q       Q    GP  GL  P  G  G+  G  P + PPGMP         PP    
Sbjct: 306 MSQ------MQLAHHGPH-GLGHPHAGPPGSG-GQPPPRPPPGMPHPGPPPMGMPPRGPP 357

Query: 851 F--PLMPPRPMPPHMMHRGPPP-----GPGGFAMPPPHG-MKGPFPPHGPFVRPGGMPGL 902
           F  P+  P PMPPH M RGPPP     G  G   PPP+G  +GP PP  P  RP   P  
Sbjct: 358 FGSPMGHPGPMPPHGM-RGPPPLMPPHGYTGPPRPPPYGYQRGPLPPPRPTPRPPVPP-- 414

Query: 903 GGPGPGP 909
            GP  GP
Sbjct: 415 RGPLRGP 421



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 96/265 (36%), Positives = 112/265 (42%), Gaps = 66/265 (24%)

Query: 678 PPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPG-FGPGVPPPPPPPPFLRPGFNPMHLPP 736
           PPP  P      PVV +L   +  PP G+PPPG F P VPPP   PP + P   P  +PP
Sbjct: 216 PPPSAPN-----PVVSSLG--SGLPPPGMPPPGSFPPPVPPPGALPPGIPPAMPPPPMPP 268

Query: 737 GFLPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMYGSAVP-PAAPTNL 795
           G    GPP   TP    P                            +G + P P  P  +
Sbjct: 269 GAAGHGPPSAGTPGAGHPG---------------------------HGHSHPHPFPPGGM 301

Query: 796 PTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMP 855
           P P ++Q       Q    GP  GL  P  G  G+  G  P + PPGMP P        P
Sbjct: 302 PHPGMSQ------MQLAHHGP-HGLGHPHAGPPGS-GGQPPPRPPPGMPHPG------PP 347

Query: 856 PRPMPPHMMHRGPPPG-PGGFAMP-PPHGMKGP---FPPHGPFVRPGGMPGLG---GPGP 907
           P  MPP    RGPP G P G   P PPHGM+GP    PPHG +  P   P  G   GP P
Sbjct: 348 PMGMPP----RGPPFGSPMGHPGPMPPHGMRGPPPLMPPHG-YTGPPRPPPYGYQRGPLP 402

Query: 908 GPGGPEDRDGRQQPPQQPQQQPQPQ 932
            P  P  R     PP+ P + P PQ
Sbjct: 403 -PPRPTPRP--PVPPRGPLRGPLPQ 424



 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 81/241 (33%), Positives = 93/241 (38%), Gaps = 67/241 (27%)

Query: 655 VSPIPKPLPVPVPPIPVPAPITVPP-----PQVPPHQPGPPV----VGALQPPAFTPPLG 705
           VS +   LP P  P P   P  VPP     P +PP  P PP+     G   P A TP  G
Sbjct: 225 VSSLGSGLPPPGMPPPGSFPPPVPPPGALPPGIPPAMPPPPMPPGAAGHGPPSAGTP--G 282

Query: 706 IPPPGFGPGVPPPPPPPPFLRPGFNPM----HLPPGFLPP--GPP-----PPITPPVSIP 754
              PG G   P P PP     PG + M    H P G   P  GPP     PP  PP  +P
Sbjct: 283 AGHPGHGHSHPHPFPPGGMPHPGMSQMQLAHHGPHGLGHPHAGPPGSGGQPPPRPPPGMP 342

Query: 755 PPHTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAP 814
            P  PP+ +P      RG                         PP   P+         P
Sbjct: 343 HPGPPPMGMP-----PRG-------------------------PPFGSPMG-------HP 365

Query: 815 GPVIGLQAPSTGLLGARPGLIP--LQRPPGMPPPHLQRFPLMPPRPMP-PHMMHRGPPPG 871
           GP+     P  G+ G  P + P     PP  PP   QR PL PPRP P P +  RGP  G
Sbjct: 366 GPM-----PPHGMRGPPPLMPPHGYTGPPRPPPYGYQRGPLPPPRPTPRPPVPPRGPLRG 420

Query: 872 P 872
           P
Sbjct: 421 P 421



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 59/180 (32%), Positives = 66/180 (36%), Gaps = 35/180 (19%)

Query: 813 APGPVI-----GLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRG 867
           AP PV+     GL  P     G+ P  +P   PPG  PP +   P MPP PMPP     G
Sbjct: 220 APNPVVSSLGSGLPPPGMPPPGSFPPPVP---PPGALPPGIP--PAMPPPPMPPGAAGHG 274

Query: 868 PPPGPGGFAMPPPHGMKGPFP-PHGPFVRPG---------GMPGLGGPGPGPGGPEDRDG 917
           PP      A  P HG   P P P G    PG         G  GLG P  GP G     G
Sbjct: 275 PPSAGTPGAGHPGHGHSHPHPFPPGGMPHPGMSQMQLAHHGPHGLGHPHAGPPG----SG 330

Query: 918 RQQPPQQPQQQPQPQAPQ-----------QPQQQQQQQPPPSQQPPPTQQQPQQFRNDNR 966
            Q PP+ P   P P  P             P       PP   + PP    P  +    R
Sbjct: 331 GQPPPRPPPGMPHPGPPPMGMPPRGPPFGSPMGHPGPMPPHGMRGPPPLMPPHGYTGPPR 390



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 45/128 (35%), Positives = 57/128 (44%), Gaps = 13/128 (10%)

Query: 634 PKKPENEVAQNG--GAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPV 691
           P   + ++A +G  G    H  P     +P P P P +P P P   PP  +PP   GPP 
Sbjct: 304 PGMSQMQLAHHGPHGLGHPHAGPPGSGGQPPPRPPPGMPHPGP---PPMGMPPR--GPPF 358

Query: 692 VGALQPPAFTPPLGI--PPPGFGP-GVPPPPPPPPFLRPGFNPMHLPPGFLPPGPPPPIT 748
              +  P   PP G+  PPP   P G   PP PPP+   G+    LPP    P PP P  
Sbjct: 359 GSPMGHPGPMPPHGMRGPPPLMPPHGYTGPPRPPPY---GYQRGPLPPPRPTPRPPVPPR 415

Query: 749 PPVSIPPP 756
            P+  P P
Sbjct: 416 GPLRGPLP 423



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 42/115 (36%), Positives = 48/115 (41%), Gaps = 15/115 (13%)

Query: 290 PAAAVPPA-PTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMM-- 346
           P  A+PP  P A  P    P AA   PP A  G PG G   P +  H +   F P  M  
Sbjct: 249 PPGALPPGIPPAMPPPPMPPGAAGHGPPSA--GTPGAG--HPGH-GHSHPHPFPPGGMPH 303

Query: 347 -GIQQDPMHHQVPL---PPNGQMPGFGLLPTP-PFPPMAQPVIPP--TPPVQQPF 394
            G+ Q  + H  P     P+   PG G  P P P P M  P  PP   PP   PF
Sbjct: 304 PGMSQMQLAHHGPHGLGHPHAGPPGSGGQPPPRPPPGMPHPGPPPMGMPPRGPPF 358



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 32/116 (27%), Positives = 41/116 (35%), Gaps = 41/116 (35%)

Query: 303 PAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQ------DPMHHQ 356
           P A  P +   PPP+ P G P  G                P  MG+         PM H 
Sbjct: 322 PHAGPPGSGGQPPPRPPPGMPHPG----------------PPPMGMPPRGPPFGSPMGHP 365

Query: 357 VPLPPNGQ------MPGFGLL-------------PTPPFPPMAQPVIPPTPPVQQP 393
            P+PP+G       MP  G               P PP  P  +P +PP  P++ P
Sbjct: 366 GPMPPHGMRGPPPLMPPHGYTGPPRPPPYGYQRGPLPPPRPTPRPPVPPRGPLRGP 421



 Score = 32.3 bits (72), Expect = 2.6
 Identities = 12/25 (48%), Positives = 15/25 (60%)

Query: 657 PIPKPLPVPVPPIPVPAPITVPPPQ 681
           P+P P P P PP+P   P+  P PQ
Sbjct: 400 PLPPPRPTPRPPVPPRGPLRGPLPQ 424



 Score = 32.0 bits (71), Expect = 3.4
 Identities = 33/125 (26%), Positives = 41/125 (32%), Gaps = 39/125 (31%)

Query: 292 AAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQD 351
           A  PP P+A  P  ++  +  PPP     G P  G   P                     
Sbjct: 212 ADAPPPPSAPNPVVSSLGSGLPPP-----GMPPPGSFPP--------------------- 245

Query: 352 PMHHQVPLPPNGQMPGFGL---LPTPPFPPMAQPVIPP---TPPVQQPFQASFQAQNEPL 405
                 P+PP G +P  G+   +P PP PP A    PP   TP    P          P 
Sbjct: 246 ------PVPPPGALPP-GIPPAMPPPPMPPGAAGHGPPSAGTPGAGHPGHGHSHPHPFPP 298

Query: 406 TQKPH 410
              PH
Sbjct: 299 GGMPH 303


>gi|21361376 splicing factor 3a, subunit 2 [Homo sapiens]
          Length = 464

 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 85/248 (34%), Positives = 107/248 (43%), Gaps = 49/248 (19%)

Query: 654 PVSPIPKPLP------VPVPPIPV--PAPITVP-PPQVPPHQPG--PPVVGALQPPAFTP 702
           P  P+P+ LP      +P+PP+P   PAP   P PPQ+PP  PG  PP      P    P
Sbjct: 243 PRPPLPESLPPPPPGGLPLPPMPPTGPAPSGPPGPPQLPPPAPGVHPPA-----PVVHPP 297

Query: 703 PLGIPPPGFGPGVPPPP----PPPPFLRPGFNPMHLP-PGFLPPGPPPPITPPVSIPPPH 757
             G+ PP   PGV PP     PP P + P  + +H P PG  PP   P + PP   P  H
Sbjct: 298 ASGVHPP--APGVHPPAPGVHPPAPGVHPPTSGVHPPAPGVHPPA--PGVHPPA--PGVH 351

Query: 758 TPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPV 817
            P   +     G      +G  V      V PAAP   P  P   P          P P 
Sbjct: 352 PPAPGVHPPAPGVHPPPSAG--VHPQAPGVHPAAPAVHPQAPGVHP----------PAPG 399

Query: 818 IGLQAPST-----GLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGP 872
           +  QAP       G+  + PG+ P  +PPG+ P +     + PP PMPP +    P  GP
Sbjct: 400 MHPQAPGVHPQPPGVHPSAPGVHP--QPPGVHPSNP---GVHPPTPMPPMLRPPLPSEGP 454

Query: 873 GGFAMPPP 880
           G    PPP
Sbjct: 455 GNIPPPPP 462



 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 90/303 (29%), Positives = 106/303 (34%), Gaps = 62/303 (20%)

Query: 657 PIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVP 716
           P P  LP   P +  P     PPP +    P PP+  +L PP   PP G+P P   P  P
Sbjct: 218 PAPPSLPAGPPGVKRP-----PPPLMNGLPPRPPLPESLPPP---PPGGLPLPPMPPTGP 269

Query: 717 PP--PPPPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNA 774
            P  PP PP L P        PG  PP P   + PP S   P  P +             
Sbjct: 270 APSGPPGPPQLPPP------APGVHPPAPV--VHPPASGVHPPAPGVH------------ 309

Query: 775 ESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGL 834
                        PPA   + P P V  P     T GV P P  G+  P+ G+    PG+
Sbjct: 310 -------------PPAPGVHPPAPGVHPP-----TSGVHP-PAPGVHPPAPGVHPPAPGV 350

Query: 835 IPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGP---PPGPGGFAMPPPHGMKGPFPPHG 891
            P       P P +   P     P  P +    P   P  PG    PP  GM    P   
Sbjct: 351 HPPAPGVHPPAPGVHPPPSAGVHPQAPGVHPAAPAVHPQAPG--VHPPAPGMHPQAPGVH 408

Query: 892 PFVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQP 951
           P   PG  P   G  P P G    +    P   P   P    P  P +     PP    P
Sbjct: 409 P-QPPGVHPSAPGVHPQPPGVHPSNPGVHP---PTPMPPMLRPPLPSEGPGNIPP----P 460

Query: 952 PPT 954
           PPT
Sbjct: 461 PPT 463



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 82/253 (32%), Positives = 97/253 (38%), Gaps = 28/253 (11%)

Query: 719 PPPPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGD 778
           PP PP L  G   +  PP  L  G PP    P S+PPP  PP  +P       G A SG 
Sbjct: 217 PPAPPSLPAGPPGVKRPPPPLMNGLPPRPPLPESLPPP--PPGGLPLPPMPPTGPAPSGP 274

Query: 779 SVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPG---PVIGLQAPSTGLLGARPGLI 835
                   +PP AP   P  PV  P +  G    APG   P  G+  P+ G+     G+ 
Sbjct: 275 PGP---PQLPPPAPGVHPPAPVVHPPA-SGVHPPAPGVHPPAPGVHPPAPGVHPPTSGVH 330

Query: 836 PLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPP----HGMKGPFPPHG 891
           P    PG+ PP     P  P    P   +H   PP PG    PPP    H       P  
Sbjct: 331 P--PAPGVHPPAPGVHPPAPGVHPPAPGVH---PPAPG--VHPPPSAGVHPQAPGVHPAA 383

Query: 892 PFVRPGGMPGLGGPGPGPGGPEDRDGRQQP----PQQPQQQPQPQA--PQQPQQQQQQQP 945
           P V P   PG+  P PG   P+      QP    P  P   PQP    P  P        
Sbjct: 384 PAVHPQA-PGVHPPAPGM-HPQAPGVHPQPPGVHPSAPGVHPQPPGVHPSNPGVHPPTPM 441

Query: 946 PPSQQPPPTQQQP 958
           PP  +PP   + P
Sbjct: 442 PPMLRPPLPSEGP 454



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 37/116 (31%), Positives = 43/116 (37%), Gaps = 17/116 (14%)

Query: 848 LQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGG--MPGLGGP 905
           +++ P  P  P  P  + R PPP   G    PP     P PP      PGG  +P +   
Sbjct: 214 MEKPPAPPSLPAGPPGVKRPPPPLMNGLPPRPPLPESLPPPP------PGGLPLPPMPPT 267

Query: 906 GPGPGGPEDRDGRQQPPQQPQQQP--QPQAP-QQPQQQQQQQPPPSQQPPPTQQQP 958
           GP P GP        PPQ P   P   P AP   P       P P   PP     P
Sbjct: 268 GPAPSGPPG------PPQLPPPAPGVHPPAPVVHPPASGVHPPAPGVHPPAPGVHP 317



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 36/107 (33%), Positives = 44/107 (41%), Gaps = 11/107 (10%)

Query: 290 PAAAVPPAPTATV-PAAAAPAAASPPP-PQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMG 347
           PA  V P P+A V P A     A+P   PQAP      G+  PA   H       P+  G
Sbjct: 360 PAPGVHPPPSAGVHPQAPGVHPAAPAVHPQAP------GVHPPAPGMHPQAPGVHPQPPG 413

Query: 348 IQQD-PMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQP 393
           +    P  H  P PP       G+ P  P PPM +P +P   P   P
Sbjct: 414 VHPSAPGVH--PQPPGVHPSNPGVHPPTPMPPMLRPPLPSEGPGNIP 458



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 41/137 (29%), Positives = 45/137 (32%), Gaps = 12/137 (8%)

Query: 288 TAPAAAVPPAPTATVPAAAA--PAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRM 345
           T PA + PP P    P A    P A    PP +    P  G+  PA   H       P  
Sbjct: 267 TGPAPSGPPGPPQLPPPAPGVHPPAPVVHPPASGVHPPAPGVHPPAPGVHPPAPGVHPPT 326

Query: 346 MGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQN--- 402
            G+   P    V  P  G  P     P P   P A  V PP P V  P  A    Q    
Sbjct: 327 SGVH--PPAPGVHPPAPGVHP-----PAPGVHPPAPGVHPPAPGVHPPPSAGVHPQAPGV 379

Query: 403 EPLTQKPHQQEMEVEQP 419
            P     H Q   V  P
Sbjct: 380 HPAAPAVHPQAPGVHPP 396



 Score = 39.3 bits (90), Expect = 0.021
 Identities = 34/107 (31%), Positives = 41/107 (38%), Gaps = 9/107 (8%)

Query: 293 AVPPAPTATVPAA----AAPAAASPP-PPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMG 347
           ++PP P   +P        PA + PP PPQ P   P  G+  PA   H       P   G
Sbjct: 250 SLPPPPPGGLPLPPMPPTGPAPSGPPGPPQLPP--PAPGVHPPAPVVHPPASGVHPPAPG 307

Query: 348 IQQDPMHHQVPLPPNGQMPGFGL-LPTPPFPPMAQPVIPPTPPVQQP 393
           +   P     P  P    P  G+  P P   P A  V PP P V  P
Sbjct: 308 V-HPPAPGVHPPAPGVHPPTSGVHPPAPGVHPPAPGVHPPAPGVHPP 353



 Score = 37.4 bits (85), Expect = 0.081
 Identities = 29/82 (35%), Positives = 31/82 (37%), Gaps = 18/82 (21%)

Query: 313 PPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLP 372
           P PP  P G PG     P            P M G+   P     PLP +   P  G LP
Sbjct: 218 PAPPSLPAGPPGVKRPPP------------PLMNGLPPRP-----PLPESLPPPPPGGLP 260

Query: 373 TPPFPPMA-QPVIPPTPPVQQP 393
            PP PP    P  PP PP   P
Sbjct: 261 LPPMPPTGPAPSGPPGPPQLPP 282



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 36/115 (31%), Positives = 43/115 (37%), Gaps = 13/115 (11%)

Query: 290 PAAAV-PPAPTATVPAAAA-PAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMG 347
           PA  V PPAP    PA    P  +   PP      P  G+  PA   H       P   G
Sbjct: 304 PAPGVHPPAPGVHPPAPGVHPPTSGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPAPG 363

Query: 348 IQQDP---MHHQVP-LPP-----NGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQP 393
           +   P   +H Q P + P     + Q PG    P P   P A P + P PP   P
Sbjct: 364 VHPPPSAGVHPQAPGVHPAAPAVHPQAPGVH-PPAPGMHPQA-PGVHPQPPGVHP 416


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 104/364 (28%), Positives = 123/364 (33%), Gaps = 42/364 (11%)

Query: 623  SDTLNPDWKGIPKKPENEV-AQNGGAET-----SHTEPVSPIPKPLPVPVPPIPVPAPIT 676
            S    P  KG P  P   + +  GG  T     + T P +  P P   P  P P  AP  
Sbjct: 1046 SPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAP-- 1103

Query: 677  VPPPQVPPHQPG----PPVVGALQPPAFTPP-----LGIPPPGFGPGVPPPPPPPP---F 724
            +PP   PP   G    PP  GA   PA TPP     L  PPP   P  P   PP P    
Sbjct: 1104 MPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGL 1163

Query: 725  LRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMYG 784
              P        P   PP P   +  P     P TP  + P+   G    +  G       
Sbjct: 1164 ATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKG--APTTP 1221

Query: 785  SAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMP 844
            +A PP+    L TP           +G    P     +P  G     P   P   PP   
Sbjct: 1222 AATPPSPKGGLATP---------SPKGAPTTPAATPPSPKGGPATPPPKGAP--TPPAAT 1270

Query: 845  PPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGP--FPPHGPFVRPGGMPGL 902
            PP L+     PP    P+     PP   GG A  PP G   P    P  P   PG  P  
Sbjct: 1271 PPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPK 1330

Query: 903  GGPGPGPGGPEDRDGRQQPPQQPQQQPQPQ-APQQPQQQQQQQPP---PSQQPPPTQQQP 958
            G P P    P    G    P  P   P  +  P  P  ++   PP   PS +  P    P
Sbjct: 1331 GAPTPPAVTPPSPKG---TPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPP 1387

Query: 959  QQFR 962
               R
Sbjct: 1388 SPKR 1391



 Score = 94.4 bits (233), Expect = 6e-19
 Identities = 103/375 (27%), Positives = 116/375 (30%), Gaps = 48/375 (12%)

Query: 628  PDWKGIPKKPENEVAQNGGAETSHTE---PVSPIPKPLPVP---VPPIPVPAPIT----- 676
            P  KG P  P  + A    A T  +    P +P PK  P P    PP P   P T     
Sbjct: 948  PSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKG 1007

Query: 677  --VPPPQVPPHQPGPPVVGALQPPAFTPPLGIPP-PGFGPGVPPPPPPPPF--------- 724
               PP   PP   G P        A TPP   PP P   P   P P   P          
Sbjct: 1008 APTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSP 1067

Query: 725  ----LRPGFNPMHLPPGFLPP----GPPPPITPPVSIPPPHTPPISIPNLVS----GARG 772
                  P       PP   PP    GP  P      +PP  TPP     L +    GA  
Sbjct: 1068 KGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPT 1127

Query: 773  NAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARP 832
               +       G A PP  P   PT P   P S  G  G+A  P  G          +  
Sbjct: 1128 TPAATPPSPKGGLATPP--PKGAPTTPAATPPSPKG--GLATPPPKGAPTTPAATPPSPK 1183

Query: 833  GLIPLQRPPGMP-----PPHLQRFPLMPPRPMPPHMMHRGPPPGP-GGFAMPPPHG--MK 884
            G +    P G P      P   +  L  P P          PP P GG A P P G    
Sbjct: 1184 GGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTT 1243

Query: 885  GPFPPHGPFVRPGGMPGLGGPGPGPGGPED-RDGRQQPPQQPQQQPQPQAPQQPQQQQQQ 943
                P  P   P   P  G P P    P   + G   PP +    P    P  P+     
Sbjct: 1244 PAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPAT 1303

Query: 944  QPPPSQQPPPTQQQP 958
             PP     PP    P
Sbjct: 1304 SPPKGAPTPPAATPP 1318



 Score = 91.7 bits (226), Expect = 4e-18
 Identities = 103/369 (27%), Positives = 126/369 (34%), Gaps = 59/369 (15%)

Query: 637  PENEVAQNGGAETSHT--EPVSPIPKPLPVP------------VPP--IPVPAPITVPPP 680
            PEN ++  G  ++  T   P  P PK  P P            +PP   P P+ + +P P
Sbjct: 837  PENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFP 896

Query: 681  QVPPHQPGPPVVGALQPPAFTP--------PLGIPPPGFGPGVPPPP---PPPPF---LR 726
            +  P  P P    AL   + +P        P GIP      G P PP   PP P      
Sbjct: 897  KEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPAT 956

Query: 727  PGFNPMHLPPGFLPP----GPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKM 782
            P       PP   PP    GP  P       PP  TPP       + +   A +  +V  
Sbjct: 957  PSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTP 1016

Query: 783  YGSAVPPAA---PTNLPTPPVTQPVSLLGTQGVAP-------GPVIGLQAPSTGLLGARP 832
                  PAA   P    TPP   P S  G+    P        P   L +P  G   A P
Sbjct: 1017 PSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGG--PATP 1074

Query: 833  GLIPLQRPPGMPPPHLQRFPLMPP---RPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPP 889
             L     PP   PP  +  P  P     PMPP       PP P G    PPH      P 
Sbjct: 1075 SLKGAPTPPAATPPSPKGGPATPSPKGAPMPP----AATPPSPKGGLATPPHKGAPTTPA 1130

Query: 890  HGPFVRPGGM---PGLGGP-GPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQP 945
              P    GG+   P  G P  P    P  + G   PP  P+  P   A   P  +     
Sbjct: 1131 ATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPP--PKGAPTTPAATPPSPKGGLAT 1188

Query: 946  PPSQQPPPT 954
            P  +  P T
Sbjct: 1189 PSPKGAPTT 1197



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 108/365 (29%), Positives = 128/365 (35%), Gaps = 71/365 (19%)

Query: 628  PDWKGIPKKPE-NEVAQNGGAET-----SHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQ 681
            P  KG P  P     +  GG  T     + T P +  P P      P P  AP T  P  
Sbjct: 1166 PPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTT--PAA 1223

Query: 682  VPPHQPG----PPVVGALQPPAFTPPLGIPPPGFGPGVPPPP----PP---PPFLRPGF- 729
             PP   G    P   GA   PA TPP     P  GP  PPP     PP   PP L+ G  
Sbjct: 1224 TPPSPKGGLATPSPKGAPTTPAATPP----SPKGGPATPPPKGAPTPPAATPPSLKGGLA 1279

Query: 730  NPMHL----PPGFLPPGPP--PPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMY 783
             P H     P    PP P   P  +PP   P   TPP + P    G+ G           
Sbjct: 1280 TPPHKGAPNPAVVTPPSPKGGPATSPPKGAP---TPPAATPPSPKGSPGT---------- 1326

Query: 784  GSAVPPAAPTNLPTPPVTQPVSLLGTQ---GVAPGPVIGLQAPSTGLLGARPGLIPLQRP 840
                PP  P   PTPP   P S  GT       P    G   PS+      P   P  + 
Sbjct: 1327 ----PP--PKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKG 1380

Query: 841  -PGMPPPHLQRFPLMP-PR--PMPPHMMHRGPPPGPG------GFAMPPPHGMKGPFPPH 890
             P M PP  +R P +P P+  P  P ++   P   P       G A P     KG   P 
Sbjct: 1381 GPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPS----KGDLTP- 1435

Query: 891  GPFVRPGGM---PGLGGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPP 947
             P V P  +   P    P  GP  P  +     P   P    +P AP+Q       +  P
Sbjct: 1436 -PAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAP 1494

Query: 948  SQQPP 952
            +   P
Sbjct: 1495 ATPAP 1499



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 80/289 (27%), Positives = 98/289 (33%), Gaps = 38/289 (13%)

Query: 628  PDWKGIPKKPENEVAQNGGAET-SHT-----EPVSP-----IPKPLPVPVPPIPVP-API 675
            P  KG P  P ++      A T SH       P SP     IP P   P  P  +P +P 
Sbjct: 1354 PSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPK 1413

Query: 676  TVPPPQVPPHQPGPPVVGALQPPAFTP------PLGIPPPGFGPGVPPPPPPPPFLRPGF 729
              P   V       P  G L PPA TP      P    P G GP  P     P       
Sbjct: 1414 KAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKG-GPATPSSKGDPTL----- 1467

Query: 730  NPMHLPPGFLPPGPPPPITPPVSIPP---PHTP-PISIPNLVSGARGNAESGDSVKMYGS 785
             P   PP   P  PP P     S  P   P TP P+  P L +    + +   +     S
Sbjct: 1468 -PAVTPPS--PKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATP--SS 1522

Query: 786  AVPPAAPT----NLPTPPVTQPV-SLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRP 840
               P APT    +  TP    P  +L+      P P      P+     A P       P
Sbjct: 1523 RRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSP 1582

Query: 841  PGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPP 889
            P + P   +  P      +PP +    P   P   A+ PP   KGP  P
Sbjct: 1583 PAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATP 1631



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 85/352 (24%), Positives = 115/352 (32%), Gaps = 41/352 (11%)

Query: 625  TLNPDWKG-IPKKPENEVAQNGGAETSHTEPVSPIPKPLPVPVPPIP----VPAPITVPP 679
            T +P  +G +   P+N   + G   T  T P+ P       PV P P     P    V  
Sbjct: 672  TASPFLEGTVSLAPKNHPVKEG---TLTTLPLVPTASE-NCPVAPSPQNTCAPLATLVLA 727

Query: 680  PQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPG-- 737
            P++P   P P +  A  PP      GI        V   P   P    G +      G  
Sbjct: 728  PEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTL 787

Query: 738  -FLPPGPPP---PITPPVSIPP-------PHTPPISIPNLVSGARGNAESGDSVKMYGSA 786
             +L   P P    ++P    PP       P TP  ++ + VS    +    +S+   GS 
Sbjct: 788  TYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSK 847

Query: 787  VPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPP 846
              PA  T+ PTPP   P        V P    G+  P        P   P      +P P
Sbjct: 848  DSPAT-THSPTPP--SPKGAPTPSAVTPLSPKGVTLP--------PKETPTPSVVNLPFP 896

Query: 847  HLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGPG 906
              +  P  P     P +      P     A P P G+     P G    P   P    P 
Sbjct: 897  --KEGPATPAPKQAPALSMTSSSPKKAR-ATPAPKGIPASPSPKGAPTPPAATP----PS 949

Query: 907  PGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQP 958
            P  GGP     +  P       P P+        +    PP+  PP  +  P
Sbjct: 950  P-KGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGP 1000



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 86/407 (21%), Positives = 125/407 (30%), Gaps = 74/407 (18%)

Query: 634  PKK-PENEVAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPVV 692
            PKK P     +   A  S  E  SP P   P      P P  + +PP    P     P  
Sbjct: 1558 PKKTPAIPTPKEAPATPSSKEASSP-PAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPT- 1615

Query: 693  GALQPPAFTPPLGIPPPGFGPGVPPP---PPPPPFLRPGFNPMHLPP-------GFLPP- 741
                PPA TP    P P  GP  P P   P  PP            P       G   P 
Sbjct: 1616 ----PPAVTP----PSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQ 1667

Query: 742  -------------------GPPPPITPPVSIPP---PHT-------PPI-SIPNLVSGAR 771
                                P P  TP ++ P    P T       PPI   P+  +G++
Sbjct: 1668 ASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSK 1727

Query: 772  G-------------NAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVI 818
            G               +S  + K   ++  P  P   P    + P++    + V P P  
Sbjct: 1728 GPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKP-- 1785

Query: 819  GLQAPSTGLLGARPGLIPLQRPPGMP--PPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFA 876
              ++ S     + P  +PL  P  +P  PP  Q  P  P   +        P        
Sbjct: 1786 --ESASVSAAPSPPVSLPL-APSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLP 1842

Query: 877  MPPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGG--PEDRDGRQQPPQQPQQQPQPQAP 934
            + PP  + G  P     V        G P P P    P  ++ +    +    +  P+  
Sbjct: 1843 LIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPELE 1902

Query: 935  QQPQQQQQQQPPPSQQPPPTQQQPQQFRNDNRQQFNSGRDQERFGRR 981
            +Q   Q   Q           ++P      +R +  + +   + G R
Sbjct: 1903 EQDSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKKARKAMSKLGLR 1949



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 82/298 (27%), Positives = 101/298 (33%), Gaps = 53/298 (17%)

Query: 130  PLLDMAAGTSNAAPVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQLPSSD-AFAA 188
            P L M   TS++   A      +G P  P    +  P  ATP S    P  PS   A   
Sbjct: 909  PALSM---TSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTP 965

Query: 189  VAQLFQTTQGQQLQQILQTFQQPP--KPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKA 246
             A    + +G       +    PP   P SP    A  +   A T     TP  P    A
Sbjct: 966  PAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPP-AVTPPSPKGSPA 1024

Query: 247  AFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAV-----TTTAPAAAVP-----P 296
            A P P+  +               P A   S K    A        T PAA +P     P
Sbjct: 1025 ATPFPKGAST-------------PPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGP 1071

Query: 297  APTATVPAAAAPAAASPPPPQ------APFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQ 350
            A T ++  A  P AA+PP P+      +P G P      PA T         P   G   
Sbjct: 1072 A-TPSLKGAPTPPAATPPSPKGGPATPSPKGAP----MPPAAT--------PPSPKGGLA 1118

Query: 351  DPMHHQVPLPPNGQMPG-FGLLPTPPFPPMAQPVIP-PTPPVQQPFQASFQAQNEPLT 406
             P H   P  P    P   G L TP  PP   P  P  TPP  +   A+   +  P T
Sbjct: 1119 TPPHKGAPTTPAATPPSPKGGLATP--PPKGAPTTPAATPPSPKGGLATPPPKGAPTT 1174



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 75/334 (22%), Positives = 121/334 (36%), Gaps = 53/334 (15%)

Query: 154  SPPPPVKVSSEPPTQATPNSVPAVPQL----PSSDAF------AAVAQLFQTTQGQQLQQ 203
            +PP P K  + P  + TP S P  P      P+S A       A V Q  +    ++   
Sbjct: 1620 TPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPT 1679

Query: 204  ILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPT---QPSEQKAAFPP---------- 250
             L+     P P+S  +  A   +         T+P     PS +  +  P          
Sbjct: 1680 ALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLL 1739

Query: 251  PEQK-TAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVP----------PAPT 299
            P QK ++   K  D       P A  ESK   +T +T  A    +P          P+P 
Sbjct: 1740 PVQKDSSKTAKGKDASHSPKGPLAPPESKA--STPLTAAAFEKVLPKPESASVSAAPSPP 1797

Query: 300  ATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPL 359
             ++P A +P    PP  Q     PG  ++ P+          +P     + + +    P 
Sbjct: 1798 VSLPLAPSPVPTLPPKQQFLPSSPGLVLESPS----------KPLAPADEDELLPLIPPE 1847

Query: 360  PPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQ---AQNEPLTQKPHQQEMEV 416
            P +G +P   +L   P P  A  +  PTP  +QP   + +    +++     P  +E + 
Sbjct: 1848 PISGGVPFQSVLVNMPTPKSA-GIPVPTPSAKQPVTKNNKGSGTESDSDESVPELEEQDS 1906

Query: 417  EQPCIQEVKRHMS---DNRKSRSRSASRSPKRRR 447
             Q   Q+ +   +   D         SRS K+ R
Sbjct: 1907 TQATTQQAQLAAAAEIDEEPVSKAKQSRSEKKAR 1940



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 40/148 (27%), Positives = 48/148 (32%), Gaps = 31/148 (20%)

Query: 277 SKKEDTTAVTTTAPAAAVPPAPTATVPAA----AAPAAASPPPPQAPFGFPGDGMQQPAY 332
           SK    T  + T P+    P P+A  P +      P   +P P      FP +G   PA 
Sbjct: 846 SKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAP 905

Query: 333 TQHQNMDQFQ---------PRMMGIQQDPMHHQVPLPPNGQMP---GFGLLPTP---PFP 377
            Q   +             P   GI   P     P PP    P   G    P+P   P P
Sbjct: 906 KQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTP 965

Query: 378 PMAQPVIP------------PTPPVQQP 393
           P A P  P            PTPP   P
Sbjct: 966 PAATPPSPKGGPATPSPKGAPTPPAATP 993



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 66/278 (23%), Positives = 82/278 (29%), Gaps = 62/278 (22%)

Query: 154  SPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQG------QQLQQILQT 207
            SP PP    +  P+  TP S   V   P      +V  L    +G      +Q   +  T
Sbjct: 855  SPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMT 914

Query: 208  FQQPPKPQSPALDNAVMAQVQ---------AITAQLKTTPTQPSEQKAAFPP-------- 250
               P K ++      + A            A     K  P  PS + A  PP        
Sbjct: 915  SSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPK 974

Query: 251  -----PEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVT---TTAPAAAVPPAPTATV 302
                 P  K A              P A   S K      +      P A  PP+P  + 
Sbjct: 975  GGPATPSPKGA-----------PTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSP 1023

Query: 303  PAAAAPAAASPPP---PQAPFG------FPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPM 353
             A   P  AS PP   P +P G       P      PA T         P   G    P 
Sbjct: 1024 AATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAAT--------LPSPKGGPATPS 1075

Query: 354  HHQVPLPPNGQMP---GFGLLPTPPFPPMAQPVIPPTP 388
                P PP    P   G    P+P   PM     PP+P
Sbjct: 1076 LKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSP 1113



 Score = 38.5 bits (88), Expect = 0.036
 Identities = 45/197 (22%), Positives = 67/197 (34%), Gaps = 20/197 (10%)

Query: 135  AAGTSNAAPVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQ 194
            A  +S   P    VT      PP  K   +  T ++P   PA P    +    AV     
Sbjct: 1457 ATPSSKGDPTLPAVTPPSPKEPPAPK---QVATSSSPKKAPATPAPMGAPTLPAVIP--- 1510

Query: 195  TTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKA-AFPPPEQ 253
             +  +++     + + P  P +  L     A +    A +    T PS +K  A P P++
Sbjct: 1511 -SSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKE 1569

Query: 254  -------KTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAA 306
                   K A     +    Y   P     S KE       T+P+    P P A  P + 
Sbjct: 1570 APATPSSKEASSPPAVTPSTYKGAP-----SPKELLIPPAVTSPSPKEAPTPPAVTPPSP 1624

Query: 307  APAAASPPPPQAPFGFP 323
                A+P P   P   P
Sbjct: 1625 EKGPATPAPKGTPTSPP 1641



 Score = 38.1 bits (87), Expect = 0.047
 Identities = 67/272 (24%), Positives = 81/272 (29%), Gaps = 47/272 (17%)

Query: 143  PVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQ 202
            P A    + +G P  P    +  P  ATP S    P  PS                    
Sbjct: 965  PPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPT-------------- 1010

Query: 203  QILQTFQQPP--KPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKK 260
                    PP   P SP    A     +  +     TP  P    AA P P+        
Sbjct: 1011 --------PPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPT---- 1058

Query: 261  LLDRFDYDDEPEAVEESKKEDTTAVT---TTAPAAAVPPAPTATVPAAAAPAAASPPPPQ 317
                      P A   S K      +      P AA PP+P    PA  +P  A P PP 
Sbjct: 1059 ---------TPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGG-PATPSPKGA-PMPPA 1107

Query: 318  APFGFPGDGMQQPAYTQHQNMD-QFQPRMMGIQQDPMHHQVPLPPNGQMPG-FGLLPTPP 375
            A    P  G+  P +           P   G    P     P  P    P   G L TP 
Sbjct: 1108 ATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATP- 1166

Query: 376  FPPMAQPVIP-PTPPVQQPFQASFQAQNEPLT 406
             PP   P  P  TPP  +   A+   +  P T
Sbjct: 1167 -PPKGAPTTPAATPPSPKGGLATPSPKGAPTT 1197



 Score = 37.7 bits (86), Expect = 0.062
 Identities = 62/275 (22%), Positives = 88/275 (32%), Gaps = 28/275 (10%)

Query: 143  PVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQ 202
            P A    + +GSP  P    +  P   TP S    P LP++   +       +++     
Sbjct: 1312 PPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTP 1371

Query: 203  QILQTFQQ------PPKPQ------SPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPP 250
                   +      PP P+      SP  D    A +     +   TP   + + AA P 
Sbjct: 1372 PAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPV--TREGAATPS 1429

Query: 251  PEQKT--AFDKKLLDRFDYDDEPEA--VEESKKEDTTAVTTTAPAAAVPPAP----TATV 302
                T  A     L +      P+      S K D T    T P+   PPAP    T++ 
Sbjct: 1430 KGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSS 1489

Query: 303  PAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVP---- 358
            P  A    A    P  P   P    + PA T     D   P    + +       P    
Sbjct: 1490 PKKAPATPAPMGAPTLPAVIPSSPKEVPA-TPSSRRDPIAPTATLLSKKTPATLAPKEAL 1548

Query: 359  LPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQP 393
            +PP   +P     P  P P  A P  P +     P
Sbjct: 1549 IPPAMTVPSPKKTPAIPTPKEA-PATPSSKEASSP 1582



 Score = 35.4 bits (80), Expect = 0.31
 Identities = 56/227 (24%), Positives = 82/227 (36%), Gaps = 43/227 (18%)

Query: 671 VPAPITVPPPQVPPHQPGPPVVGALQPPA----FTPPLGIPPPGFGPGVPPPPPPPPFLR 726
           +P   T   P      P P    A+ P +     T  LG P    GP +PPP  P P   
Sbjct: 1   MPGEATETVPATEQELPQPQAETAVLPMSSALSVTAALGQP----GPTLPPPCSPAPQQC 56

Query: 727 PGFNPMHLPPGFLPPGPPPPITPPVSIPPPHT-------------PPISIPNLVSGARGN 773
           P        P    P P    + P+ +P P +              P  +PNL+      
Sbjct: 57  PLSAANQASPF---PSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISP 113

Query: 774 AESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLL-----GTQGVAPGPVIGLQAPSTGLL 828
           A           A P  APT   TP  + P++L+       Q  +  P   L +P +  +
Sbjct: 114 A-------ALALASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAV 166

Query: 829 GARPGLIPLQRP--PGMPPPHLQRFP--LMP-PR--PMPPHMMHRGP 868
                +I L  P  P  P  +L + P  ++P P+  P PP ++   P
Sbjct: 167 AESGSVITLSAPIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVP 213



 Score = 35.4 bits (80), Expect = 0.31
 Identities = 45/188 (23%), Positives = 71/188 (37%), Gaps = 33/188 (17%)

Query: 145 AENVTNNEGSPPPPVKVSSEP-----PTQATPNSVPAVPQ-LPSSDAFAAVAQLFQTTQG 198
           +E V N +G+P PP  VS+ P     P  +  + V ++PQ  P++    A  Q+  TT  
Sbjct: 193 SEVVPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLAIASPQVKDTT-- 250

Query: 199 QQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFP--PPEQKTA 256
                I      P  P S +L   V +   A++   ++ P   S QK A P  PP+   +
Sbjct: 251 -----ISSVLISPQNPGSLSLKGPV-SPPAALSLSTQSLPVVTSSQKTAGPNTPPDFPIS 304

Query: 257 FDKKLLDRFDYD---------------DEPEAVEESKKEDTTAVTTTAPAAAVPPAPT-- 299
               L                       +P     S    +T  +  +  + +PP P+  
Sbjct: 305 LGSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGASYPSQRSVIPPLPSRN 364

Query: 300 ATVPAAAA 307
             VPA  A
Sbjct: 365 EVVPATVA 372



 Score = 35.0 bits (79), Expect = 0.40
 Identities = 63/288 (21%), Positives = 83/288 (28%), Gaps = 42/288 (14%)

Query: 149  TNNEGSPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQQILQTF 208
            T    +PP P    + PP +  P +  A P  P         +   TT            
Sbjct: 1150 TTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGL 1209

Query: 209  QQPPKPQSPALDNAVMAQVQA--ITAQLKTTPTQPSEQKA------AFPPPEQKTAFDKK 260
              P    +P    A     +    T   K  PT P+          A PPP+        
Sbjct: 1210 ATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPT---- 1265

Query: 261  LLDRFDYDDEPEAVEESKK-----------EDTTAVTTTAPA---AAVPPAPTATVPAAA 306
                      P A   S K            +   VT  +P    A  PP    T PAA 
Sbjct: 1266 ---------PPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAAT 1316

Query: 307  APAAASPPPPQAPFGFP-GDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQM 365
             P+    P    P G P    +  P+      +    P   G    P   + P PP    
Sbjct: 1317 PPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATP 1376

Query: 366  PGFGLLPTPPFPPMAQPVIP-----PTPPVQQPFQASFQAQNEPLTQK 408
               G     P  P   P IP     PT P   P     +A   P+T++
Sbjct: 1377 SHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPK-KAPATPVTRE 1423



 Score = 31.2 bits (69), Expect = 5.8
 Identities = 41/152 (26%), Positives = 54/152 (35%), Gaps = 22/152 (14%)

Query: 654 PVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPP--PGF 711
           P+S   +  P P P      P+ VP PQ                     PLG  P  P F
Sbjct: 57  PLSAANQASPFPSPSTIASTPLEVPFPQ--------------SSSGTALPLGTAPEAPTF 102

Query: 712 GPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISI--PNLVSG 769
            P +  PP  P  L    +PM  P     P    P+   V++ P      S   PNL++ 
Sbjct: 103 LPNLIGPPISPAALALA-SPMIAPTLKGTPSSSAPLA-LVALAPHSVQKSSAFPPNLLTS 160

Query: 770 --ARGNAESGDSVKMYGSAVPPAAPTNLPTPP 799
             +   AESG  + +     P    TNL   P
Sbjct: 161 PPSVAVAESGSVITLSAPIAPSEPKTNLNKVP 192



 Score = 30.4 bits (67), Expect = 9.9
 Identities = 50/198 (25%), Positives = 69/198 (34%), Gaps = 27/198 (13%)

Query: 650 SHTEPVSPIPKPLPVPVPPIPVPAPI----TVPPPQVPPHQPG--PPVVGALQPPAFTPP 703
           S     SP P P  +   P+ VP P     T  P    P  P   P ++G   PP     
Sbjct: 59  SAANQASPFPSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIG---PPISPAA 115

Query: 704 LGIPPPGFGP---GVPPPPPPPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPP 760
           L +  P   P   G P    P   +    + +     F    PP  +T P S+    +  
Sbjct: 116 LALASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAF----PPNLLTSPPSVAVAESGS 171

Query: 761 I---SIPNLVSGARGNAESGDSVKM---YGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAP 814
           +   S P   S  + N     S  +    G+  PP   + +P   VT   S+    GVA 
Sbjct: 172 VITLSAPIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVTPMASI--QSGVAS 229

Query: 815 GPVIGLQAPSTGLLGARP 832
            P      P+T L  A P
Sbjct: 230 LP---QTTPTTTLAIASP 244


>gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]
          Length = 1012

 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 105/378 (27%), Positives = 132/378 (34%), Gaps = 78/378 (20%)

Query: 617 EGGMLDSDTLNPDWKGIPKKPENEVAQNGGAETSHTEPVSPIPKP-------------LP 663
           EG   DS ++N +    PK  + +           T P  P P+              L 
Sbjct: 130 EGESSDSRSVNDEGSSDPKDIDQD--------NRSTSPSIPSPQDNESDSDSSAQQQMLQ 181

Query: 664 VPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPP 723
              P +  P  +T  P   PP  P  P  G        PP G P     P  P  P  P 
Sbjct: 182 AQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAP- 240

Query: 724 FLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMY 783
                   +   P   P  PP P  PP   P PH PP+  P   S  + +A S     ++
Sbjct: 241 ---VPHTHIQQAPALHPQRPPSPHPPP--HPSPH-PPLQ-PLTGSAGQPSAPSHAQPPLH 293

Query: 784 GSAVP---------------PAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLL 828
           G   P               P  P  LP P  +Q  + LGT   A  P   LQ P     
Sbjct: 294 GQGPPGPHSLQAGPLLQHPGPPQPFGLP-PQASQGQAPLGTSPAAAYPHTSLQLP----- 347

Query: 829 GARPGLIPLQRPP---GMPP-----PHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPP 880
            A    +  Q+PP    +PP     PH++  P  P   +P    H+ PP   G    P P
Sbjct: 348 -ASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSG----PSP 402

Query: 881 HGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQ--PQQQPQPQAPQQPQ 938
             M    PP  P ++P  +  L    P    P        PP Q  PQ QP P +P QP 
Sbjct: 403 FSMNANLPP-PPALKP--LSSLSTHHPPSAHP--------PPLQLMPQSQPLPSSPAQPP 451

Query: 939 --QQQQQQPPPSQQPPPT 954
              Q Q  PPP    PPT
Sbjct: 452 GLTQSQNLPPPPASHPPT 469



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 129/507 (25%), Positives = 179/507 (35%), Gaps = 112/507 (22%)

Query: 646  GAETSHTEPVSPIPKPLPVPVPPI-------PVPAPITVPPPQVPPHQPGPPVVGALQPP 698
            G+ T+   P  P     PVP   I       P   P   PPP   PH P  P+ G+   P
Sbjct: 223  GSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQP 282

Query: 699  AFT----PPL-GIPPPG-----FGPGVPPPPPPPPF-LRPGFNPMHLPPGFLP------- 740
            +      PPL G  PPG      GP +  P PP PF L P  +    P G  P       
Sbjct: 283  SAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHT 342

Query: 741  --------------------PGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSV 780
                                P PP P+  P   PPP TP   +P   +       SG S 
Sbjct: 343  SLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPS- 401

Query: 781  KMYGSAVPPAAPTNLPTPPVTQPVSLLGTQ---GVAPGPVIGLQAPSTGLLGARPGLIPL 837
                   P +   NLP PP  +P+S L T       P P           L   P   PL
Sbjct: 402  -------PFSMNANLPPPPALKPLSSLSTHHPPSAHPPP-----------LQLMPQSQPL 443

Query: 838  QRPPGMPPPHLQRFPLMPPRPM-PPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPF-VR 895
               P  PP   Q   L PP    PP  +H+  P  P  FA       + PF P GP  + 
Sbjct: 444  PSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPP--FA-------QHPFVPGGPPPIT 494

Query: 896  PGGMPGLGGPGPGPG-------------GPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQ 942
            P   P    P  GPG             G     G   P   P  Q + +A    ++ + 
Sbjct: 495  PPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCP--LPTVQIKEEALDDAEEPES 552

Query: 943  QQPPP-SQQPPPT-------QQQPQQFRNDNRQQFNSGRDQERFGRRSFGNRVENDRERY 994
              PPP S  P PT         Q  +F     + +NS    + +     G+++   RE  
Sbjct: 553  PPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKRE-- 610

Query: 995  GNRNDDRDNSNRDRREWGRRSPDRDRHRDLEERNRRSSGHRDRERDSRDRESRREKEEAR 1054
                +  + + R+  +  R   +R++ ++ +ER R     R+ ER ++   S  E     
Sbjct: 611  ----EAIEKAKREAEQKAREEREREKEKE-KEREREREREREAERAAKASSSAHEGR--- 662

Query: 1055 GKEKPEVTDRAGGNKTVEPPISQVGNV 1081
                P+++       + EPP + +  V
Sbjct: 663  -LSDPQLSGPGHMRPSFEPPPTTIAAV 688



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 99/422 (23%), Positives = 144/422 (34%), Gaps = 77/422 (18%)

Query: 154 SPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPK 213
           SP PP   S  PP Q    S       PS+ + A      Q   G    Q     Q P  
Sbjct: 259 SPHPPPHPSPHPPLQPLTGSAGQ----PSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGP 314

Query: 214 PQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEA 273
           PQ   L      Q     A L T+P       +   P  Q     ++          P A
Sbjct: 315 PQPFGLP----PQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLA 370

Query: 274 VEESKKEDTTAVTTT-APAA----------------AVPPAPTATVPAAAA----PAAAS 312
           +   K   TT +    AP A                A  P P A  P ++     P +A 
Sbjct: 371 MPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAH 430

Query: 313 PPP----PQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGF 368
           PPP    PQ+    P    Q P  TQ QN+    P         +H   P PP  Q P  
Sbjct: 431 PPPLQLMPQSQ-PLPSSPAQPPGLTQSQNLP---PPPASHPPTGLHQVAPQPPFAQHPFV 486

Query: 369 GLLPTPPFPPM--------------AQPVIP---------------PTPPVQQPFQASFQ 399
              P P  PP               AQP                  P P VQ   +A   
Sbjct: 487 PGGPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDD 546

Query: 400 AQNEPLTQKPHQQEMEVEQPCIQEVKRHMSDNRKSRSR------SASRSPKRRRSRSGSR 453
           A+ EP +  P  +    E P + +   H S + +          S +R+       +GS+
Sbjct: 547 AE-EPESPPPPPRSPSPE-PTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSK 604

Query: 454 SRRSRHRRSRSRSRDRRRHSPRSRSQERRDREKERERRQKGLPQVKPETASVCSTTLWVG 513
             +   +R  +  + +R    ++R +  R++EKE+ER ++   + + E A+  S++   G
Sbjct: 605 LAK---KREEAIEKAKREAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHEG 661

Query: 514 QL 515
           +L
Sbjct: 662 RL 663



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 59/234 (25%), Positives = 74/234 (31%), Gaps = 54/234 (23%)

Query: 758 TPPISIPNLVSGARGNAESGDSVKMYGSAVPP-------AAPTNLPTPP----------- 799
           T  IS PN  S   G +    SV   GS+ P        +   ++P+P            
Sbjct: 117 TQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQ 176

Query: 800 ----VTQPVSLLGTQGVAPGPVIGL----QAPSTGLLGARPGLIPLQRPPGMPPPHLQRF 851
                 QP +L    GV P P        Q P+ G   +   + P   P     P+    
Sbjct: 177 QQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQ--- 233

Query: 852 PLMPPRPMPPHMMHRGP------PPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGP 905
           P  P  P+P   + + P      PP P     PPPH    P PP  P     G P     
Sbjct: 234 PQAPTAPVPHTHIQQAPALHPQRPPSPH----PPPH--PSPHPPLQPLTGSAGQPSA--- 284

Query: 906 GPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQPQ 959
                         QPP   Q  P P + Q     Q   PP     PP   Q Q
Sbjct: 285 ----------PSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQ 328



 Score = 37.7 bits (86), Expect = 0.062
 Identities = 59/284 (20%), Positives = 96/284 (33%), Gaps = 19/284 (6%)

Query: 135 AAGTSNAAPVAENVTNNEGSPPPPVKVSS-EPPTQATPNSVPAVPQLPSSDAFAAVAQ-- 191
           A+     +P+ E++ ++  + P     SS +   +    S   V +  SS   +   Q  
Sbjct: 39  ASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQRE 98

Query: 192 --LFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAA-- 247
                T +  +        Q+  +P SP+      +  +++  +  + P    +   +  
Sbjct: 99  KVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTS 158

Query: 248 --FPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAA 305
              P P+   +       +     +P A++ +    T A ++  P     P P  T  A 
Sbjct: 159 PSIPSPQDNESDSDSSAQQQMLQAQPPALQ-APTGVTPAPSSAPPGTPQLPTPGPTPSAT 217

Query: 306 AAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQM 365
           A P   SP   QAP   P        +T  Q      P+       P H   P P     
Sbjct: 218 AVPPQGSPTASQAP-NQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPH---PSPHPPLQ 273

Query: 366 PGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKP 409
           P  G    P  P  AQP +    P   P   S QA   PL Q P
Sbjct: 274 PLTGSAGQPSAPSHAQPPLHGQGP---PGPHSLQA--GPLLQHP 312


>gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 105/378 (27%), Positives = 132/378 (34%), Gaps = 78/378 (20%)

Query: 617  EGGMLDSDTLNPDWKGIPKKPENEVAQNGGAETSHTEPVSPIPKP-------------LP 663
            EG   DS ++N +    PK  + +           T P  P P+              L 
Sbjct: 684  EGESSDSRSVNDEGSSDPKDIDQD--------NRSTSPSIPSPQDNESDSDSSAQQQMLQ 735

Query: 664  VPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPP 723
               P +  P  +T  P   PP  P  P  G        PP G P     P  P  P  P 
Sbjct: 736  AQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAP- 794

Query: 724  FLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMY 783
                    +   P   P  PP P  PP   P PH PP+  P   S  + +A S     ++
Sbjct: 795  ---VPHTHIQQAPALHPQRPPSPHPPP--HPSPH-PPLQ-PLTGSAGQPSAPSHAQPPLH 847

Query: 784  GSAVP---------------PAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLL 828
            G   P               P  P  LP P  +Q  + LGT   A  P   LQ P     
Sbjct: 848  GQGPPGPHSLQAGPLLQHPGPPQPFGLP-PQASQGQAPLGTSPAAAYPHTSLQLP----- 901

Query: 829  GARPGLIPLQRPP---GMPP-----PHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPP 880
             A    +  Q+PP    +PP     PH++  P  P   +P    H+ PP   G    P P
Sbjct: 902  -ASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSG----PSP 956

Query: 881  HGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQ--PQQQPQPQAPQQPQ 938
              M    PP  P ++P  +  L    P    P        PP Q  PQ QP P +P QP 
Sbjct: 957  FSMNANLPP-PPALKP--LSSLSTHHPPSAHP--------PPLQLMPQSQPLPSSPAQPP 1005

Query: 939  --QQQQQQPPPSQQPPPT 954
               Q Q  PPP    PPT
Sbjct: 1006 GLTQSQNLPPPPASHPPT 1023



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 129/507 (25%), Positives = 179/507 (35%), Gaps = 112/507 (22%)

Query: 646  GAETSHTEPVSPIPKPLPVPVPPI-------PVPAPITVPPPQVPPHQPGPPVVGALQPP 698
            G+ T+   P  P     PVP   I       P   P   PPP   PH P  P+ G+   P
Sbjct: 777  GSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQP 836

Query: 699  AFT----PPL-GIPPPG-----FGPGVPPPPPPPPF-LRPGFNPMHLPPGFLP------- 740
            +      PPL G  PPG      GP +  P PP PF L P  +    P G  P       
Sbjct: 837  SAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHT 896

Query: 741  --------------------PGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSV 780
                                P PP P+  P   PPP TP   +P   +       SG S 
Sbjct: 897  SLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPS- 955

Query: 781  KMYGSAVPPAAPTNLPTPPVTQPVSLLGTQ---GVAPGPVIGLQAPSTGLLGARPGLIPL 837
                   P +   NLP PP  +P+S L T       P P           L   P   PL
Sbjct: 956  -------PFSMNANLPPPPALKPLSSLSTHHPPSAHPPP-----------LQLMPQSQPL 997

Query: 838  QRPPGMPPPHLQRFPLMPPRPM-PPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPF-VR 895
               P  PP   Q   L PP    PP  +H+  P  P  FA       + PF P GP  + 
Sbjct: 998  PSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPP--FA-------QHPFVPGGPPPIT 1048

Query: 896  PGGMPGLGGPGPGPG-------------GPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQ 942
            P   P    P  GPG             G     G   P   P  Q + +A    ++ + 
Sbjct: 1049 PPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCP--LPTVQIKEEALDDAEEPES 1106

Query: 943  QQPPP-SQQPPPT-------QQQPQQFRNDNRQQFNSGRDQERFGRRSFGNRVENDRERY 994
              PPP S  P PT         Q  +F     + +NS    + +     G+++   RE  
Sbjct: 1107 PPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKRE-- 1164

Query: 995  GNRNDDRDNSNRDRREWGRRSPDRDRHRDLEERNRRSSGHRDRERDSRDRESRREKEEAR 1054
                +  + + R+  +  R   +R++ ++ +ER R     R+ ER ++   S  E     
Sbjct: 1165 ----EAIEKAKREAEQKAREEREREKEKE-KEREREREREREAERAAKASSSAHEGR--- 1216

Query: 1055 GKEKPEVTDRAGGNKTVEPPISQVGNV 1081
                P+++       + EPP + +  V
Sbjct: 1217 -LSDPQLSGPGHMRPSFEPPPTTIAAV 1242



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 99/422 (23%), Positives = 144/422 (34%), Gaps = 77/422 (18%)

Query: 154  SPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPK 213
            SP PP   S  PP Q    S       PS+ + A      Q   G    Q     Q P  
Sbjct: 813  SPHPPPHPSPHPPLQPLTGSAGQ----PSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGP 868

Query: 214  PQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEA 273
            PQ   L      Q     A L T+P       +   P  Q     ++          P A
Sbjct: 869  PQPFGLP----PQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLA 924

Query: 274  VEESKKEDTTAVTTT-APAA----------------AVPPAPTATVPAAAA----PAAAS 312
            +   K   TT +    AP A                A  P P A  P ++     P +A 
Sbjct: 925  MPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAH 984

Query: 313  PPP----PQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGF 368
            PPP    PQ+    P    Q P  TQ QN+    P         +H   P PP  Q P  
Sbjct: 985  PPPLQLMPQSQ-PLPSSPAQPPGLTQSQNLP---PPPASHPPTGLHQVAPQPPFAQHPFV 1040

Query: 369  GLLPTPPFPPM--------------AQPVIP---------------PTPPVQQPFQASFQ 399
               P P  PP               AQP                  P P VQ   +A   
Sbjct: 1041 PGGPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDD 1100

Query: 400  AQNEPLTQKPHQQEMEVEQPCIQEVKRHMSDNRKSRSR------SASRSPKRRRSRSGSR 453
            A+ EP +  P  +    E P + +   H S + +          S +R+       +GS+
Sbjct: 1101 AE-EPESPPPPPRSPSPE-PTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSK 1158

Query: 454  SRRSRHRRSRSRSRDRRRHSPRSRSQERRDREKERERRQKGLPQVKPETASVCSTTLWVG 513
              +   +R  +  + +R    ++R +  R++EKE+ER ++   + + E A+  S++   G
Sbjct: 1159 LAK---KREEAIEKAKREAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHEG 1215

Query: 514  QL 515
            +L
Sbjct: 1216 RL 1217



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 59/234 (25%), Positives = 74/234 (31%), Gaps = 54/234 (23%)

Query: 758 TPPISIPNLVSGARGNAESGDSVKMYGSAVPP-------AAPTNLPTPP----------- 799
           T  IS PN  S   G +    SV   GS+ P        +   ++P+P            
Sbjct: 671 TQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQ 730

Query: 800 ----VTQPVSLLGTQGVAPGPVIGL----QAPSTGLLGARPGLIPLQRPPGMPPPHLQRF 851
                 QP +L    GV P P        Q P+ G   +   + P   P     P+    
Sbjct: 731 QQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQ--- 787

Query: 852 PLMPPRPMPPHMMHRGP------PPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGP 905
           P  P  P+P   + + P      PP P     PPPH    P PP  P     G P     
Sbjct: 788 PQAPTAPVPHTHIQQAPALHPQRPPSPH----PPPH--PSPHPPLQPLTGSAGQPSA--- 838

Query: 906 GPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQPQ 959
                         QPP   Q  P P + Q     Q   PP     PP   Q Q
Sbjct: 839 ----------PSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQ 882



 Score = 37.7 bits (86), Expect = 0.062
 Identities = 59/284 (20%), Positives = 96/284 (33%), Gaps = 19/284 (6%)

Query: 135 AAGTSNAAPVAENVTNNEGSPPPPVKVSS-EPPTQATPNSVPAVPQLPSSDAFAAVAQ-- 191
           A+     +P+ E++ ++  + P     SS +   +    S   V +  SS   +   Q  
Sbjct: 593 ASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQRE 652

Query: 192 --LFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAA-- 247
                T +  +        Q+  +P SP+      +  +++  +  + P    +   +  
Sbjct: 653 KVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTS 712

Query: 248 --FPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAA 305
              P P+   +       +     +P A++ +    T A ++  P     P P  T  A 
Sbjct: 713 PSIPSPQDNESDSDSSAQQQMLQAQPPALQ-APTGVTPAPSSAPPGTPQLPTPGPTPSAT 771

Query: 306 AAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQM 365
           A P   SP   QAP   P        +T  Q      P+       P H   P P     
Sbjct: 772 AVPPQGSPTASQAP-NQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPH---PSPHPPLQ 827

Query: 366 PGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKP 409
           P  G    P  P  AQP +    P   P   S QA   PL Q P
Sbjct: 828 PLTGSAGQPSAPSHAQPPLHGQGP---PGPHSLQA--GPLLQHP 866



 Score = 31.2 bits (69), Expect = 5.8
 Identities = 20/73 (27%), Positives = 36/73 (49%), Gaps = 2/73 (2%)

Query: 988  ENDRERYGNRNDDRDNSNRDR-REWGRRSPDRDRHRDLEERNRRSSGHRDRERDSRDRES 1046
            + D+E+  +R+ DR+   RD+ RE     P R    +   +N   S H + E D+ +  +
Sbjct: 8    DKDKEKDRDRDRDREREKRDKARESENSRPRRSCTLEGGAKNYAESDHSEDE-DNDNNSA 66

Query: 1047 RREKEEARGKEKP 1059
              E+   + K+KP
Sbjct: 67   TAEESTKKNKKKP 79


>gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 105/378 (27%), Positives = 132/378 (34%), Gaps = 78/378 (20%)

Query: 617  EGGMLDSDTLNPDWKGIPKKPENEVAQNGGAETSHTEPVSPIPKP-------------LP 663
            EG   DS ++N +    PK  + +           T P  P P+              L 
Sbjct: 684  EGESSDSRSVNDEGSSDPKDIDQD--------NRSTSPSIPSPQDNESDSDSSAQQQMLQ 735

Query: 664  VPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPP 723
               P +  P  +T  P   PP  P  P  G        PP G P     P  P  P  P 
Sbjct: 736  AQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAP- 794

Query: 724  FLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMY 783
                    +   P   P  PP P  PP   P PH PP+  P   S  + +A S     ++
Sbjct: 795  ---VPHTHIQQAPALHPQRPPSPHPPP--HPSPH-PPLQ-PLTGSAGQPSAPSHAQPPLH 847

Query: 784  GSAVP---------------PAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLL 828
            G   P               P  P  LP P  +Q  + LGT   A  P   LQ P     
Sbjct: 848  GQGPPGPHSLQAGPLLQHPGPPQPFGLP-PQASQGQAPLGTSPAAAYPHTSLQLP----- 901

Query: 829  GARPGLIPLQRPP---GMPP-----PHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPP 880
             A    +  Q+PP    +PP     PH++  P  P   +P    H+ PP   G    P P
Sbjct: 902  -ASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSG----PSP 956

Query: 881  HGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQ--PQQQPQPQAPQQPQ 938
              M    PP  P ++P  +  L    P    P        PP Q  PQ QP P +P QP 
Sbjct: 957  FSMNANLPP-PPALKP--LSSLSTHHPPSAHP--------PPLQLMPQSQPLPSSPAQPP 1005

Query: 939  --QQQQQQPPPSQQPPPT 954
               Q Q  PPP    PPT
Sbjct: 1006 GLTQSQNLPPPPASHPPT 1023



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 129/507 (25%), Positives = 179/507 (35%), Gaps = 112/507 (22%)

Query: 646  GAETSHTEPVSPIPKPLPVPVPPI-------PVPAPITVPPPQVPPHQPGPPVVGALQPP 698
            G+ T+   P  P     PVP   I       P   P   PPP   PH P  P+ G+   P
Sbjct: 777  GSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQP 836

Query: 699  AFT----PPL-GIPPPG-----FGPGVPPPPPPPPF-LRPGFNPMHLPPGFLP------- 740
            +      PPL G  PPG      GP +  P PP PF L P  +    P G  P       
Sbjct: 837  SAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHT 896

Query: 741  --------------------PGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSV 780
                                P PP P+  P   PPP TP   +P   +       SG S 
Sbjct: 897  SLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPS- 955

Query: 781  KMYGSAVPPAAPTNLPTPPVTQPVSLLGTQ---GVAPGPVIGLQAPSTGLLGARPGLIPL 837
                   P +   NLP PP  +P+S L T       P P           L   P   PL
Sbjct: 956  -------PFSMNANLPPPPALKPLSSLSTHHPPSAHPPP-----------LQLMPQSQPL 997

Query: 838  QRPPGMPPPHLQRFPLMPPRPM-PPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPF-VR 895
               P  PP   Q   L PP    PP  +H+  P  P  FA       + PF P GP  + 
Sbjct: 998  PSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPP--FA-------QHPFVPGGPPPIT 1048

Query: 896  PGGMPGLGGPGPGPG-------------GPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQ 942
            P   P    P  GPG             G     G   P   P  Q + +A    ++ + 
Sbjct: 1049 PPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCP--LPTVQIKEEALDDAEEPES 1106

Query: 943  QQPPP-SQQPPPT-------QQQPQQFRNDNRQQFNSGRDQERFGRRSFGNRVENDRERY 994
              PPP S  P PT         Q  +F     + +NS    + +     G+++   RE  
Sbjct: 1107 PPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKRE-- 1164

Query: 995  GNRNDDRDNSNRDRREWGRRSPDRDRHRDLEERNRRSSGHRDRERDSRDRESRREKEEAR 1054
                +  + + R+  +  R   +R++ ++ +ER R     R+ ER ++   S  E     
Sbjct: 1165 ----EAIEKAKREAEQKAREEREREKEKE-KEREREREREREAERAAKASSSAHEGR--- 1216

Query: 1055 GKEKPEVTDRAGGNKTVEPPISQVGNV 1081
                P+++       + EPP + +  V
Sbjct: 1217 -LSDPQLSGPGHMRPSFEPPPTTIAAV 1242



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 99/422 (23%), Positives = 144/422 (34%), Gaps = 77/422 (18%)

Query: 154  SPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPK 213
            SP PP   S  PP Q    S       PS+ + A      Q   G    Q     Q P  
Sbjct: 813  SPHPPPHPSPHPPLQPLTGSAGQ----PSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGP 868

Query: 214  PQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEA 273
            PQ   L      Q     A L T+P       +   P  Q     ++          P A
Sbjct: 869  PQPFGLP----PQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLA 924

Query: 274  VEESKKEDTTAVTTT-APAA----------------AVPPAPTATVPAAAA----PAAAS 312
            +   K   TT +    AP A                A  P P A  P ++     P +A 
Sbjct: 925  MPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAH 984

Query: 313  PPP----PQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGF 368
            PPP    PQ+    P    Q P  TQ QN+    P         +H   P PP  Q P  
Sbjct: 985  PPPLQLMPQSQ-PLPSSPAQPPGLTQSQNLP---PPPASHPPTGLHQVAPQPPFAQHPFV 1040

Query: 369  GLLPTPPFPPM--------------AQPVIP---------------PTPPVQQPFQASFQ 399
               P P  PP               AQP                  P P VQ   +A   
Sbjct: 1041 PGGPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDD 1100

Query: 400  AQNEPLTQKPHQQEMEVEQPCIQEVKRHMSDNRKSRSR------SASRSPKRRRSRSGSR 453
            A+ EP +  P  +    E P + +   H S + +          S +R+       +GS+
Sbjct: 1101 AE-EPESPPPPPRSPSPE-PTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSK 1158

Query: 454  SRRSRHRRSRSRSRDRRRHSPRSRSQERRDREKERERRQKGLPQVKPETASVCSTTLWVG 513
              +   +R  +  + +R    ++R +  R++EKE+ER ++   + + E A+  S++   G
Sbjct: 1159 LAK---KREEAIEKAKREAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHEG 1215

Query: 514  QL 515
            +L
Sbjct: 1216 RL 1217



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 59/234 (25%), Positives = 74/234 (31%), Gaps = 54/234 (23%)

Query: 758 TPPISIPNLVSGARGNAESGDSVKMYGSAVPP-------AAPTNLPTPP----------- 799
           T  IS PN  S   G +    SV   GS+ P        +   ++P+P            
Sbjct: 671 TQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQ 730

Query: 800 ----VTQPVSLLGTQGVAPGPVIGL----QAPSTGLLGARPGLIPLQRPPGMPPPHLQRF 851
                 QP +L    GV P P        Q P+ G   +   + P   P     P+    
Sbjct: 731 QQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQ--- 787

Query: 852 PLMPPRPMPPHMMHRGP------PPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGP 905
           P  P  P+P   + + P      PP P     PPPH    P PP  P     G P     
Sbjct: 788 PQAPTAPVPHTHIQQAPALHPQRPPSPH----PPPH--PSPHPPLQPLTGSAGQPSA--- 838

Query: 906 GPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQPQ 959
                         QPP   Q  P P + Q     Q   PP     PP   Q Q
Sbjct: 839 ----------PSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQ 882



 Score = 37.7 bits (86), Expect = 0.062
 Identities = 59/284 (20%), Positives = 96/284 (33%), Gaps = 19/284 (6%)

Query: 135 AAGTSNAAPVAENVTNNEGSPPPPVKVSS-EPPTQATPNSVPAVPQLPSSDAFAAVAQ-- 191
           A+     +P+ E++ ++  + P     SS +   +    S   V +  SS   +   Q  
Sbjct: 593 ASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQRE 652

Query: 192 --LFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAA-- 247
                T +  +        Q+  +P SP+      +  +++  +  + P    +   +  
Sbjct: 653 KVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTS 712

Query: 248 --FPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAA 305
              P P+   +       +     +P A++ +    T A ++  P     P P  T  A 
Sbjct: 713 PSIPSPQDNESDSDSSAQQQMLQAQPPALQ-APTGVTPAPSSAPPGTPQLPTPGPTPSAT 771

Query: 306 AAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQM 365
           A P   SP   QAP   P        +T  Q      P+       P H   P P     
Sbjct: 772 AVPPQGSPTASQAP-NQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPH---PSPHPPLQ 827

Query: 366 PGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKP 409
           P  G    P  P  AQP +    P   P   S QA   PL Q P
Sbjct: 828 PLTGSAGQPSAPSHAQPPLHGQGP---PGPHSLQA--GPLLQHP 866



 Score = 31.2 bits (69), Expect = 5.8
 Identities = 20/73 (27%), Positives = 36/73 (49%), Gaps = 2/73 (2%)

Query: 988  ENDRERYGNRNDDRDNSNRDR-REWGRRSPDRDRHRDLEERNRRSSGHRDRERDSRDRES 1046
            + D+E+  +R+ DR+   RD+ RE     P R    +   +N   S H + E D+ +  +
Sbjct: 8    DKDKEKDRDRDRDREREKRDKARESENSRPRRSCTLEGGAKNYAESDHSEDE-DNDNNSA 66

Query: 1047 RREKEEARGKEKP 1059
              E+   + K+KP
Sbjct: 67   TAEESTKKNKKKP 79


>gi|151301053 RNA binding motif protein 33 [Homo sapiens]
          Length = 1170

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 103/343 (30%), Positives = 126/343 (36%), Gaps = 71/343 (20%)

Query: 654 PVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGP 713
           P  P P P   P+  +  P P+    P   PH P PP    + P   TP + + P    P
Sbjct: 320 PPPPPPPPQQQPIRSLFQPQPLQPLLPVQHPHHPSPPQGMHMPPQLETPRMMMTP----P 375

Query: 714 GVPPPPPPPPFLRPGF-----NPMHLPPGFLPPGPPPPITPPVSIPPPHTP---PISIPN 765
            V P  P    + P F      P+ +P   +P  P P + P     PP  P   P  +PN
Sbjct: 376 PVTPQQPKNIHINPHFKGTVVTPVQVPLLPVPSQPRPAVGPQRFPGPPEFPQHTPGPVPN 435

Query: 766 LVSGARGNAESGDSVKMYGSAVPPAAPT----NLPTPPVTQPVSLLGTQGV--------- 812
             S                   PP  P       P PP  +    LG  G          
Sbjct: 436 SFS------------------QPPRLPLQDQWRAPPPPQDRDPFFLGVSGEPRFPSHLFL 477

Query: 813 ---APGPVIGLQAPSTGLLGARPGLIPLQRP-----PGMPPPHLQRFPLMP-PRPMPPHM 863
              +P P      P T L  + P  +P Q P     PG       + P+ P  RP+ P +
Sbjct: 478 EQRSPPPP---PPPPTLLNSSHP--VPTQSPLPFTQPGPAFNQQGQQPVFPRERPVRPAL 532

Query: 864 MHRGPPPGPGG---FAMPPPHGMKGPFPPHGPFVRPGGMPGLGGPG----PGPGGPEDRD 916
                PPGP G   F+ P     +   PP  PF+   G P L         GP  P    
Sbjct: 533 Q----PPGPVGILHFSQPGSATTRPFIPPRQPFLPGPGQPFLPTHTQPNLQGPLHPPLPP 588

Query: 917 GRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQPQ 959
             Q  PQQPQQQP PQ   QP  Q   QPPP  QPPP Q  PQ
Sbjct: 589 PHQPQPQQPQQQPPPQ--HQPPHQPPHQPPPQHQPPP-QHPPQ 628



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 71/301 (23%), Positives = 100/301 (33%), Gaps = 53/301 (17%)

Query: 156 PPPVKVSSEPPTQATPNSV----PAVPQLPSSDAFAAVAQLFQTTQGQQLQQILQTFQQP 211
           P P +    PP   TP  +    P  PQ P +     +   F+ T    +Q  L      
Sbjct: 353 PSPPQGMHMPPQLETPRMMMTPPPVTPQQPKN---IHINPHFKGTVVTPVQVPLLPVPSQ 409

Query: 212 PKP-----QSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRFD 266
           P+P     + P            +       P  P + +   PPP Q             
Sbjct: 410 PRPAVGPQRFPGPPEFPQHTPGPVPNSFSQPPRLPLQDQWRAPPPPQ------------- 456

Query: 267 YDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDG 326
            D +P  +  S +    +       +  PP P  T+  ++ P     P    PF  PG  
Sbjct: 457 -DRDPFFLGVSGEPRFPSHLFLEQRSPPPPPPPPTLLNSSHPVPTQSP---LPFTQPGPA 512

Query: 327 M----QQPAYTQHQNMDQF--QPRMMGIQQDPMHHQVP--------LPPNGQM---PGFG 369
                QQP + + + +      P  +GI    +H   P        +PP       PG  
Sbjct: 513 FNQQGQQPVFPRERPVRPALQPPGPVGI----LHFSQPGSATTRPFIPPRQPFLPGPGQP 568

Query: 370 LLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQ---QEMEVEQPCIQEVKR 426
            LPT   P +  P+ PP PP  QP     Q Q  P  Q PHQ   Q     QP  Q   +
Sbjct: 569 FLPTHTQPNLQGPLHPPLPPPHQPQPQQPQQQPPPQHQPPHQPPHQPPPQHQPPPQHPPQ 628

Query: 427 H 427
           H
Sbjct: 629 H 629



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 87/352 (24%), Positives = 114/352 (32%), Gaps = 63/352 (17%)

Query: 155 PPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQ------LFQTTQGQQL---QQIL 205
           P PP      P     PNS    P+LP  D + A          F    G+        L
Sbjct: 420 PGPPEFPQHTPGP--VPNSFSQPPRLPLQDQWRAPPPPQDRDPFFLGVSGEPRFPSHLFL 477

Query: 206 QTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRF 265
           +    PP P  P L N+       +  Q     TQP     AF    Q+  F ++   R 
Sbjct: 478 EQRSPPPPPPPPTLLNSS----HPVPTQSPLPFTQPGP---AFNQQGQQPVFPRERPVRP 530

Query: 266 DYDDEPEAVEESKKEDTTAVTTTA---------PAAAVPPAPTATVPAAAAPAAASPPPP 316
                P  V         + TT           P    P  PT T P    P     PPP
Sbjct: 531 ALQP-PGPVGILHFSQPGSATTRPFIPPRQPFLPGPGQPFLPTHTQPNLQGPLHPPLPPP 589

Query: 317 -----QAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLL 371
                Q P   P    Q P    HQ   Q QP      Q P  HQ     +        +
Sbjct: 590 HQPQPQQPQQQPPPQHQPPHQPPHQPPPQHQPPPQHPPQHPPQHQ-----HHHHHHHLSV 644

Query: 372 PTPPFPPMAQPVIPPTPPVQQPFQASFQAQ------------NEPLTQKPHQQEMEV--- 416
           P PP  PM+QP   P     QP  +S + Q            ++ ++++P QQ       
Sbjct: 645 PPPPLMPMSQPQFRPHVQTAQPQASSSRMQCPQRQGLRHNTTSQNVSKRPMQQMQPTAPR 704

Query: 417 -----EQPCIQEVKRHMSDNRKSRSRSASRSP-----KRRRSRSGSRSRRSR 458
                E P        MS +R S + SA   P        R+ +GSRS + +
Sbjct: 705 NSNLRELPIAPSHVIEMSSSRCSATPSAQVKPIVSASPPSRAVAGSRSSQGK 756



 Score = 37.0 bits (84), Expect = 0.11
 Identities = 24/45 (53%), Positives = 27/45 (60%), Gaps = 5/45 (11%)

Query: 370 LLPT-PPFPPMAQPVIPPTPPVQQPFQASFQAQN-EPL--TQKPH 410
           LLPT PP  P A P  PP PP QQP ++ FQ Q  +PL   Q PH
Sbjct: 308 LLPTQPPVVPQAPPP-PPPPPQQQPIRSLFQPQPLQPLLPVQHPH 351


>gi|71044479 death inducer-obliterator 1 isoform c [Homo sapiens]
          Length = 2240

 Score = 93.6 bits (231), Expect = 9e-19
 Identities = 146/515 (28%), Positives = 196/515 (38%), Gaps = 116/515 (22%)

Query: 677  VPPPQVPPHQPGPPVVGALQP-PAFTPPLGIPPPGF-GPGVPPPPPPPPFLRPGFNPMHL 734
            +PPP        PP  G  +P P      G+  P F GP  P PP P   +     P   
Sbjct: 1736 LPPPGQKVGGSQPPFQGQREPGPHALGMSGLHGPNFPGPRGPAPPFPEENIASNDGPRGP 1795

Query: 735  PPGFL--PPGPPPPITPPVSIPPPHTPPIS-IPNLVSGARGNAESG-------DSVKMYG 784
            PP       GP P +      PPP+       P+ + G RG A S           K   
Sbjct: 1796 PPARFGAQKGPIPSLFSGQHGPPPYGDSRGPSPSYLGGPRGVAPSQFEERKDPHGEKREF 1855

Query: 785  SAVPPAAPTNLPTP-PVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGM 843
               P    T  P     T+    LG++G AP    G +         RP L  L+ P G 
Sbjct: 1856 QDAPYNEVTGAPAQFEGTEQAPFLGSRGGAPFQFGGQR---------RPLLSQLKGPRGG 1906

Query: 844  PPPHL---QRFPLMPPR----PMPPHMMH----RGPPP----GPGGFA---MPPPHGMKG 885
            PPP     QR P  PP     P  PH       RGP P    GP G A   MP P G++ 
Sbjct: 1907 PPPSQFGGQRGP--PPGHFVGPRGPHPSQFETARGPHPNQFEGPRGQAPNFMPGPRGIQP 1964

Query: 886  P--------FPPHGPFVR---PGGMPGLGGPGPGPGGPEDRDGR----QQPPQQPQQQPQ 930
                      PP     R   P    GL G  P     E    R     Q PQ  +  P+
Sbjct: 1965 QQFEDQRVHSPPRFTNQRAPAPLQFGGLRGSAPFSEKNEQTPSRFHFQGQAPQVMKPGPR 2024

Query: 931  P--QAPQQPQQQQQQQ-----PPPSQQPPPTQQQPQ--------QFR----NDNRQQFNS 971
            P  + P  P Q ++ +     PP +       Q P+         FR    ++ R Q   
Sbjct: 2025 PLLELPSHPPQHRKDRWEEAGPPSALSSSAPGQGPEADGQWASADFREGKGHEYRNQTFE 2084

Query: 972  GRDQERF---------------GRRSFGNRVENDRERYGNRNDDRD-----NSNRDR--- 1008
            GR +ERF               GR S   R E +R R  +R  D D     + +RD+   
Sbjct: 2085 GRQRERFDVGPKEKPLEEPDAQGRASEDRRRERERGRNWSRERDWDRPREWDRHRDKDSS 2144

Query: 1009 REWGR---RSPDRDRHRDLE-----ERNRRSSGHRDRERD---SRDRESRREKEEARGKE 1057
            R+W R   RS +RDR R+ +     +R+R  S +R+RERD    RDR   RE++  + ++
Sbjct: 2145 RDWDRNRERSANRDREREADRGKEWDRSRERSRNRERERDRRRDRDRSRSRERDRDKARD 2204

Query: 1058 KPEVTDRAGGNKTVE------PPISQVGNVDTASE 1086
            +    DR   +K+ E      P  S+  +  TAS+
Sbjct: 2205 RERGRDRKDRSKSKESARDPKPEASRASDAGTASQ 2239



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 25/68 (36%), Positives = 36/68 (52%)

Query: 430  DNRKSRSRSASRSPKRRRSRSGSRSRRSRHRRSRSRSRDRRRHSPRSRSQERRDREKERE 489
            +    R +   RS +R R+R   R RR    RSRSR RDR +   R R ++R+DR K +E
Sbjct: 2160 EREADRGKEWDRSRERSRNRERERDRRRDRDRSRSRERDRDKARDRERGRDRKDRSKSKE 2219

Query: 490  RRQKGLPQ 497
              +   P+
Sbjct: 2220 SARDPKPE 2227



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 37/135 (27%), Positives = 62/135 (45%), Gaps = 16/135 (11%)

Query: 385  PPTPPVQQPF---QASFQAQNEPLTQKPHQQEMEVEQPCIQEVKRHMSDNR---KSRSRS 438
            P   P+++P    +AS   + E    +   +E + ++P   +  R    +R   ++R RS
Sbjct: 2095 PKEKPLEEPDAQGRASEDRRRERERGRNWSRERDWDRPREWDRHRDKDSSRDWDRNRERS 2154

Query: 439  ASRSPKRR----------RSRSGSRSRRSRHRRSRSRSRDRRRHSPRSRSQERRDREKER 488
            A+R  +R           R RS +R R    RR R RSR R R   ++R +ER    K+R
Sbjct: 2155 ANRDREREADRGKEWDRSRERSRNRERERDRRRDRDRSRSRERDRDKARDRERGRDRKDR 2214

Query: 489  ERRQKGLPQVKPETA 503
             + ++     KPE +
Sbjct: 2215 SKSKESARDPKPEAS 2229



 Score = 43.9 bits (102), Expect = 9e-04
 Identities = 40/183 (21%), Positives = 68/183 (37%), Gaps = 6/183 (3%)

Query: 947  PSQQPPPTQQQPQQFRNDNRQQFNSGRDQE------RFGRRSFGNRVENDRERYGNRNDD 1000
            P + PPP QQ     R   RQ   + R ++      R GRRS    +E+  E       D
Sbjct: 47   PLEPPPPQQQLGLSLRRSGRQPKRTERVEQFLTIARRRGRRSMPVSLEDSGEPTSCPATD 106

Query: 1001 RDNSNRDRREWGRRSPDRDRHRDLEERNRRSSGHRDRERDSRDRESRREKEEARGKEKPE 1060
             + ++    E    +    +      + R +S  + +  D  D  S  + +    KE   
Sbjct: 107  AETASEGSVESASETRSGPQSASTAVKERPASSEKVKGGDDHDDTSDSDSDGLTLKELQN 166

Query: 1061 VTDRAGGNKTVEPPISQVGNVDTASELEKGVSEAAVLKPSEELPAEATSSVEPEKDSGSA 1120
               R    +  E P+  + +       E+G +E    + S+ +     S  EPE D G  
Sbjct: 167  RLRRKREQEPTERPLKGIQSRLRKKRREEGPAETVGSEASDTVEGVLPSKQEPENDQGVV 226

Query: 1121 AEA 1123
            ++A
Sbjct: 227  SQA 229



 Score = 39.7 bits (91), Expect = 0.016
 Identities = 76/353 (21%), Positives = 120/353 (33%), Gaps = 58/353 (16%)

Query: 149  TNNEGSPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQ-------L 201
            T   GSPPPP  +   P  +   +  PA P   ++   AA A    ++           L
Sbjct: 1255 TTPPGSPPPPPPLPEPPVLKVLSSLKPAAPSPATAATTAAAASTAASSTASSASKTASPL 1314

Query: 202  QQILQTF-----------QQPP-----KPQSP--ALDNAVMAQ------VQAITAQLKTT 237
            + ILQT            ++PP      PQ P    ++ V A       VQ      K  
Sbjct: 1315 EHILQTLFGKKKSFDPSAREPPGSTAGLPQEPKTTAEDGVPAPPLLDPIVQQFGQFSKDK 1374

Query: 238  PTQPSEQKAAFPPPEQ---KTAFDKKLLD---RFDYDDEPEAVEESKKE---DTTAVTTT 288
              +  E    + P E+   + AFD +L++   R + +  PEA    ++E   D    T  
Sbjct: 1375 ALEEEEDDRPYDPEEEYDPERAFDTQLVERGRRHEVERAPEAAAAEREEVAYDPEDETIL 1434

Query: 289  APA-AAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMG 347
              A   V   P          +   P  P A    P    QQ    +     + Q R + 
Sbjct: 1435 EEAKVTVDDLPNRMCADVRRNSVERPAEPVAGAATPSLVEQQKMLEELNKQIEEQKRQLE 1494

Query: 348  IQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQ 407
             Q++ +  Q        M  F +      PP    +     P  + FQ   Q+ ++P + 
Sbjct: 1495 EQEEALRQQ-RAAVGVSMAHFSVSDALMSPPPKSSL-----PKAELFQQEQQSADKPASL 1548

Query: 408  KPHQQEMEVEQPCIQEVKRHMSDNRKSRSRSASR---------SPKRRRSRSG 451
             P  Q      P  ++ +R  ++  +      SR          P+R  SR G
Sbjct: 1549 PPASQASNHRDP--RQARRLAAETGEGEGEPLSRLSARGAQGALPERDASRGG 1599



 Score = 38.1 bits (87), Expect = 0.047
 Identities = 37/104 (35%), Positives = 43/104 (41%), Gaps = 22/104 (21%)

Query: 870  PGPGGFAMPPPHGMK--GPFPPHGPFVRPG----GMPGLGGPG-PGPGGP---------E 913
            PG G   +PPP G K  G  PP      PG    GM GL GP  PGP GP          
Sbjct: 1729 PGEGTAPLPPP-GQKVGGSQPPFQGQREPGPHALGMSGLHGPNFPGPRGPAPPFPEENIA 1787

Query: 914  DRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPP---SQQPPPT 954
              DG + PP  P +    + P       Q  PPP   S+ P P+
Sbjct: 1788 SNDGPRGPP--PARFGAQKGPIPSLFSGQHGPPPYGDSRGPSPS 1829



 Score = 35.0 bits (79), Expect = 0.40
 Identities = 67/306 (21%), Positives = 110/306 (35%), Gaps = 42/306 (13%)

Query: 104 SEDKSKIVRVLNLWQKNGVFKIEIIQPLLDMAAGTSNAAPVAENVTNNEG---------- 153
           SED+    R+      +G  K++I QP+++    +    P   +V   +           
Sbjct: 361 SEDQGIKGRIEKAANPSGKKKLKIFQPVIEAPGASKCIGPGCCHVAQPDSVYCSNDCILK 420

Query: 154 SPPPPVKVSS-----EPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQQILQTF 208
                +K  S     +P  +      P  P LP   A A +             +I    
Sbjct: 421 HAAATMKFLSSGKEQKPKPKEKMKMKPEKPSLPKCGAQAGI-------------KISSVH 467

Query: 209 QQP-PKPQSPALDNAVM--AQVQAITAQL---KTTPTQPSEQKAAFPPPEQKTAFDKKLL 262
           ++P P+ +   +  AV+  A+ +A+  +     +TP+  S+       PE+  A    LL
Sbjct: 468 KRPAPEKKETTVKKAVVVPARSEALGKEAACESSTPSWASDHNYNAVKPEKTAAPSPSLL 527

Query: 263 DRFDYDDEPEAVEESKKEDTTAVTTTAPAAAV--PPAPTATVP---AAAAPAAASPPPPQ 317
            +   +D     EE       +  T  P +AV   PAP   VP   + A  AAA+P   +
Sbjct: 528 YKSTKEDRRS--EEKAAAMAASKKTAPPGSAVGKQPAPRNLVPKKSSFANVAAATPAIKK 585

Query: 318 APFGFPGDGMQQPAYTQHQNMDQFQPRMMG-IQQDPMHHQVPLPPNGQMPGFGLLPTPPF 376
            P GF G   ++P  +   +      R  G             P +  + G    P  P 
Sbjct: 586 PPSGFKGTIPKRPWLSATPSSGASAARQAGPAPAAATAASKKFPGSAALVGAVRKPVVPS 645

Query: 377 PPMAQP 382
            PMA P
Sbjct: 646 VPMASP 651



 Score = 30.8 bits (68), Expect = 7.6
 Identities = 42/149 (28%), Positives = 51/149 (34%), Gaps = 26/149 (17%)

Query: 660  KPLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPP 719
            +P    VP  P  A  TVP  +  P +   P+  A    + TPP          G PPPP
Sbjct: 1219 QPEEADVPAYPKVA--TVPQSEKKPSKY--PLCSADAAVSTTPP----------GSPPPP 1264

Query: 720  PPPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAES--- 776
            PP P   P   P+      L P  P P T   +     T   S  +  S      E    
Sbjct: 1265 PPLP--EP---PVLKVLSSLKPAAPSPATAATTAAAASTAASSTASSASKTASPLEHILQ 1319

Query: 777  ---GDSVKMYGSA-VPPAAPTNLPTPPVT 801
               G       SA  PP +   LP  P T
Sbjct: 1320 TLFGKKKSFDPSAREPPGSTAGLPQEPKT 1348


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 105/360 (29%), Positives = 125/360 (34%), Gaps = 58/360 (16%)

Query: 623 SDTLNPDWKGIPKKPENEVAQNGGAETSHTEPVSPIPKPLPVPV-PPIPVPAPITVPPPQ 681
           + T   D   +P + +    Q   A+    E V P    LP P  PPI  P P   PP Q
Sbjct: 262 TQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKP---SLPSPSKPPIQQPTP-GKPPAQ 317

Query: 682 VPPH---QPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPGF 738
            P H   QPGP    A QP   T PL   P    P V PP    P               
Sbjct: 318 QPGHEKSQPGPAKPPA-QPSGLTKPLAQQPGTVKPPVQPPGTTKP--------------- 361

Query: 739 LPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTP 798
            P  P  P  PP        P    P   + A+         +  G A PP      P P
Sbjct: 362 -PAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKP 420

Query: 799 PVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRP 858
              QP   L +   APGP        T +    PG IP Q+         Q  P  PP  
Sbjct: 421 LAQQPG--LQSPAKAPGPT------KTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQ 472

Query: 859 MPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGG-MPGLGGPGPGPGGPEDRDG 917
           +P       PPP   G A PPP   + P     P  +PG   P    PGP    P+    
Sbjct: 473 LPGPAK---PPPQQPGPAKPPP---QQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGS 526

Query: 918 RQQPPQQP------QQQPQPQAPQQPQQQ---------QQQQPP---PSQQPPPTQQQPQ 959
            + P QQP       QQP P  P   Q           +  QPP   PS + PP+Q  P+
Sbjct: 527 TKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPK 586



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 100/349 (28%), Positives = 119/349 (34%), Gaps = 75/349 (21%)

Query: 660 KPLPVPVPPI----PVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGV 715
           KP  +  PP+    P P P    P + P  Q G P   + Q P     +   PPG G  +
Sbjct: 202 KPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPE---KIKSQPPGTGKPI 258

Query: 716 PPPPPPP-------PFLRPGFNPMHLPPGFL-----PPGPPPPITPPVSIPPPHTPPISI 763
             P   P       P  R    P       +      P  P P  PP+  P P  PP   
Sbjct: 259 QGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQ 318

Query: 764 PNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQP------VSLLGT-----QGV 812
           P            G      G A PPA P+ L  P   QP      V   GT     Q +
Sbjct: 319 P------------GHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPL 366

Query: 813 APGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGP 872
            P      Q  S      +PG   L +PPG+      + P   P P  P     G P   
Sbjct: 367 GPAKPPAQQTGSEKPSSEQPGPKALAQPPGVG-----KTPAQQPGPAKPPTQQVGTPKP- 420

Query: 873 GGFAMPPPHGMKGPFPPHGPFVRPGGMPGLG-------GPGP------GPGGPEDR-DGR 918
              A  P  G++ P    GP   P   PG G       GPG       GP  P  +  G 
Sbjct: 421 --LAQQP--GLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGP 476

Query: 919 QQPPQQ-------PQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQPQQ 960
            +PP Q       P QQP    P  P QQ     PP QQP P +  PQQ
Sbjct: 477 AKPPPQQPGPAKPPPQQPGSAKP--PSQQPGSTKPPPQQPGPAKPSPQQ 523



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 48/171 (28%), Positives = 61/171 (35%), Gaps = 28/171 (16%)

Query: 655  VSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPV---------------------VG 693
            +S  P P P P PP P P P   PPP  PP  P P +                     V 
Sbjct: 2401 ISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVT 2460

Query: 694  ALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRP-GFNPMHLPPGFLPPGPPPPITP--P 750
             L+  A     G+P        PPP PP P   P G    H P    PP  P P+ P  P
Sbjct: 2461 TLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLP 2520

Query: 751  VSIPPP---HTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTP 798
             +   P   H  P  + +L S    N  +    K+     P +  +N  +P
Sbjct: 2521 TTTQKPTDIHPKPTGL-SLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSP 2570



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 72/328 (21%), Positives = 110/328 (33%), Gaps = 49/328 (14%)

Query: 143 PVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQ 202
           P+ ++ T    S   P K+ S+PP    P   P                  QT Q    +
Sbjct: 229 PLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPT-----------------QTPQTDHAK 271

Query: 203 QILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLL 262
             LQ  +   +PQ+   D   + + +++   L +    P +Q     PP Q+   +K   
Sbjct: 272 LPLQ--RDASRPQTKQAD---IVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQP 326

Query: 263 DRFDYDDEPEAVEESKKEDTTAV--------TTTAPAAAVPPAPTATVPAAAAPAAASPP 314
                  +P  + +   +    V        TT  PA  + PA        +   ++  P
Sbjct: 327 GPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQP 386

Query: 315 PPQAPFGFPGDGM---QQPAYTQHQNMDQFQPRMMGIQ---QDPMHHQVPLPPNGQMPGF 368
            P+A    PG G    QQP   +        P+ +  Q   Q P     P     Q PG 
Sbjct: 387 GPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGP 446

Query: 369 GLLP-------------TPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEME 415
           G +P             T P  P +Q   P  PP QQP  A    Q     + P QQ   
Sbjct: 447 GKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGS 506

Query: 416 VEQPCIQEVKRHMSDNRKSRSRSASRSP 443
            + P  Q      S  +   ++  S+ P
Sbjct: 507 TKPPPQQPGPAKPSPQQPGSTKPPSQQP 534



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 50/175 (28%), Positives = 64/175 (36%), Gaps = 19/175 (10%)

Query: 709  PGFGPGVPP-PPPPPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNLV 767
            P   P V   P  P PF R     +   P   PP PPPP  PP   PPP  PP + P   
Sbjct: 2377 PSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPT 2436

Query: 768  SGARGNAESGDSVKMYGSAVPP-AAPTNLPTPPVTQ----PVSLLGTQGVAPGPVIGLQA 822
               +        V    +A P   A T L T  V +    PV+ + T    P P      
Sbjct: 2437 ILPKKKLTVASPVT---TATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSI 2493

Query: 823  PSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAM 877
            PS  +   RP      +PP  P P + + P    +P   H       P P G ++
Sbjct: 2494 PSGLVFTHRP---EPSKPPIAPKPVIPQLPTTTQKPTDIH-------PKPTGLSL 2538



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 87/411 (21%), Positives = 124/411 (30%), Gaps = 90/411 (21%)

Query: 626  LNPDWKGIPKKPENEVAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPP- 684
            L  D   +P  P+ ++       TS     SP P+         P       P P+ PP 
Sbjct: 646  LGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPP 705

Query: 685  --HQP---GPPVVGALQPPAFTPPLGIPPPGFGPGVPPP----------PPPPPFLRPGF 729
               QP   G P   A QPP     L  P P   P VP            P  P  ++P  
Sbjct: 706  LVKQPTLHGSPSAKAKQPPE-ADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTT 764

Query: 730  NPMHLPPGFLPPGPP-------------PPITPPVSIPPPHTPPI----------SIPNL 766
            + +        P  P             PP+    + P    PP           +IP  
Sbjct: 765  DLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRP 824

Query: 767  VSGARGNAESGDSVKMYGSAV---------PPAAPTNLPTPPVTQPVSLLGTQGVAPGPV 817
             S ++  +  G S +  G            P  A T +   P  +P+         P P 
Sbjct: 825  ASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPT 884

Query: 818  IGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLM--------PPRPMPPHMMHRGPP 869
             G   P+           P Q P   P    +RF L           +P  P     G  
Sbjct: 885  AGQTVPT-----------PQQSPK--PQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKL 931

Query: 870  PGPGGF------------AMPPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDG 917
             G G                P PH   GP  P      P   P   GP    G       
Sbjct: 932  FGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPA 991

Query: 918  RQQPPQQPQQQP-----QPQAPQQP---QQQQQQQPPPSQQPPPTQQQPQQ 960
            +  P ++  + P     +P+A Q P   + + +++PPP +       +PQ+
Sbjct: 992  KSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQK 1042



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 79/346 (22%), Positives = 121/346 (34%), Gaps = 59/346 (17%)

Query: 153  GSPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVA--QLFQTTQGQQLQQILQTFQQ 210
            GSP    K   E  + + P + P  P +PS    A VA  +  Q    +    ++ +   
Sbjct: 714  GSPSAKAKQPPEADSLSKP-APPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSA 772

Query: 211  PPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTA-FDKKLLDRFDYDD 269
              KP  P+      A+ +  T  LKT   +PS+   +FPP  +K + FD K + R   D 
Sbjct: 773  TTKPDIPSSKVQSQAE-EKTTPPLKTDSAKPSQ---SFPPTGEKVSPFDSKAIPRPASDS 828

Query: 270  E----PEAVEESK-----------KEDTTAVTTTAP---------AAAVPPAPTATVPAA 305
            +    P    ESK           +E   A T  +P          +  PP P  T    
Sbjct: 829  KIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQT 888

Query: 306  AAPAAASPPPPQAPFGFP---GDGMQQPAYTQHQNMDQFQPRMMGI-------------- 348
                  SP P +    F    G     P        +    ++ G               
Sbjct: 889  VPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLIST 948

Query: 349  --QQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTP----PVQQPFQASFQAQN 402
              Q  P     P  P  Q P     PT   PP +    PP P    PV++  +A    + 
Sbjct: 949  AGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKL 1008

Query: 403  EPLTQKP---HQQEMEVEQPCIQEVKRHMSDNRKS-RSRSASRSPK 444
            EP  ++     + E E + P I++ K   ++ +K+       +SPK
Sbjct: 1009 EPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPK 1054



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 57/212 (26%), Positives = 76/212 (35%), Gaps = 58/212 (27%)

Query: 633  IPKKPENEVAQNGGAETSHTE-PVSPIPKPLP----VPVPPIPV----PAPITVPPPQVP 683
            +P K +         ET   E P S +P   P    +P  P P        I+  PP  P
Sbjct: 2350 LPMKEQLSTTYFTSGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPP 2409

Query: 684  PHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGP 743
            P  P PP                PPP      PPPPPPP           LPP   P  P
Sbjct: 2410 PPPPPPP----------------PPP------PPPPPPP-----------LPP---PTSP 2433

Query: 744  PPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMYG---SAVPPAAPTNLPTPPV 800
             P I P   +      P++    +  A    E+   ++  G   + +   AP  +P  P 
Sbjct: 2434 KPTILPKKKLTV--ASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPS 2491

Query: 801  TQPVSLLGTQ-------GVAPGPVIGLQAPST 825
            + P  L+ T         +AP PVI  Q P+T
Sbjct: 2492 SIPSGLVFTHRPEPSKPPIAPKPVIP-QLPTT 2522



 Score = 38.1 bits (87), Expect = 0.047
 Identities = 49/204 (24%), Positives = 63/204 (30%), Gaps = 49/204 (24%)

Query: 788  PPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPH 847
            PP++   LP          L T     G   G + P++ L    P +  L   P  P P 
Sbjct: 2343 PPSSVIALPMK------EQLSTTYFTSGETFGQEKPASQLPSGSPSVSSL---PAKPRPF 2393

Query: 848  LQRFPL----MPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPF---------- 893
             +   L     PP P PP      PPP P    +PPP   K    P              
Sbjct: 2394 FRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTAT 2453

Query: 894  --------------VRPGGMP----GLGGPGPGPGGPEDRDG-----RQQPPQQPQQQPQ 930
                          +R  G+P        P P P  P           +  P +P   P+
Sbjct: 2454 PLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPK 2513

Query: 931  PQAPQQPQQQQQQQPPPSQQPPPT 954
            P  PQ P   Q+   P    P PT
Sbjct: 2514 PVIPQLPTTTQK---PTDIHPKPT 2534



 Score = 37.0 bits (84), Expect = 0.11
 Identities = 38/149 (25%), Positives = 53/149 (35%), Gaps = 31/149 (20%)

Query: 269  DEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQ 328
            + P    +++        T   +  VPP    T    ++PA     P QAP         
Sbjct: 3854 ERPRTAPQTEFSQFIPPQTQTESQLVPPTSPYTQYQYSSPAL----PTQAP--------- 3900

Query: 329  QPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTP 388
              +YTQ  + +Q         Q   H QV   P    P F  + T  F P  QP   P P
Sbjct: 3901 -TSYTQQSHFEQ---------QTLYHQQVS--PYQTQPTFQAVATMSFTPQVQPTPTPQP 3948

Query: 389  PVQQPFQASFQAQNEPLTQKPHQQEMEVE 417
              Q P      +Q   + QKP Q  + +E
Sbjct: 3949 SYQLP------SQMMVIQQKPRQTTLYLE 3971



 Score = 36.6 bits (83), Expect = 0.14
 Identities = 98/446 (21%), Positives = 130/446 (29%), Gaps = 128/446 (28%)

Query: 634 PKKPENEVAQNGGAETSHTEPVSPIPKPL-PVPVPPIPVPAPITVPPPQVP------PHQ 686
           P KP  +  Q G A+    +P S  P P  P P  P P     T PP Q P        Q
Sbjct: 486 PAKPPPQ--QPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQ 543

Query: 687 PGPPVVGALQPPAFTPPLG----IPPPGFGPGVPPPPPP--PPFLRPGFNP----MHLPP 736
           P P    A Q        G    + PP   P    PP    P  + P  N     +H+P 
Sbjct: 544 PSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPE 603

Query: 737 ------------------GFLPPGPPPPIT---------------------PPVSIPPPH 757
                             GF    P P +T                     P  S P P 
Sbjct: 604 KANFNTCTECQTTVCSLCGF---NPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPK 660

Query: 758 --TPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPG 815
             T P++  + VS +    +     K    A P    +  P P    P+    T   +P 
Sbjct: 661 LKTAPVTTTSAVSKSSPQPQQTSPKK---DAAPKQDLSKAPEPKKPPPLVKQPTLHGSPS 717

Query: 816 PVIGLQAPSTGLLGARPGLIPLQRPPGMP--PPHLQRFPLMPPRPMPPHMM--------- 864
                Q P    L ++P       PP  P  P    + P+   +P  P M+         
Sbjct: 718 AK-AKQPPEADSL-SKPA------PPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSS 769

Query: 865 -------------------HRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGP 905
                               +  PP     A P        FPP G  V P     +  P
Sbjct: 770 SSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQS-----FPPTGEKVSPFDSKAIPRP 824

Query: 906 G--------PGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQPP---PT 954
                    PGP        +  P Q+ ++  + Q    P+   +  P  S  PP   PT
Sbjct: 825 ASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPT 884

Query: 955 --------QQQPQQFRNDNRQQFNSG 972
                   QQ P+      R   N G
Sbjct: 885 AGQTVPTPQQSPKPQEQSRRFSLNLG 910



 Score = 35.4 bits (80), Expect = 0.31
 Identities = 75/358 (20%), Positives = 127/358 (35%), Gaps = 61/358 (17%)

Query: 118  QKNGVFKIEIIQPLLDMAAGTSNAAPVAENVTNNEGSPPPP------------VKVSSEP 165
            +  G  +++ +Q   +     +  +P  +     +GSP PP             + S +P
Sbjct: 839  ESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKP 898

Query: 166  PTQA------------TPNSVPAVPQ-LPSSDAFAAVAQLFQTTQGQQLQQILQTFQQPP 212
              Q+             P S P  PQ   +   F   A +F      Q   ++ T  Q P
Sbjct: 899  QEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIF-----SQASNLISTAGQ-P 952

Query: 213  KPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPP--------EQKTAFDKKLLDR 264
             P S +   A M Q  A  +Q  T+   P     A P P        E K    +KL  +
Sbjct: 953  GPHSQSGPGAPMKQAPA-PSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPK 1011

Query: 265  FDYDDEPEAVEESKK----EDTTAVTTTAPAAAVP------PAPTATVPAAAAPAAASPP 314
             +     +  E  KK    +D+ ++T     A +P      P P +T P           
Sbjct: 1012 AEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSK 1071

Query: 315  PPQAPFGFPGDGMQQPAYTQHQNMDQFQ--PRMMGIQQ-DPMHHQVPLPPNGQMPGFGLL 371
             P      P          Q  N+  F   P +  IQ+   ++ Q     +GQ+     +
Sbjct: 1072 DP------PNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKM 1125

Query: 372  PTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEMEVEQPCIQEVKRHMS 429
            P  P  P A P+  PT    Q  + +   Q + + ++  + + E E+  +++VK  +S
Sbjct: 1126 PPAPSGPKASPMPVPTESSSQ--KTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLS 1181



 Score = 34.7 bits (78), Expect = 0.52
 Identities = 53/236 (22%), Positives = 78/236 (33%), Gaps = 25/236 (10%)

Query: 143 PVAENVTNNEGSPPPPVKVSSEPP-TQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQL 201
           P  +  +    S  P  K  ++PP    TP   P  P  P +        L Q    Q  
Sbjct: 372 PAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPG-PAKPPTQQVGTPKPLAQQPGLQSP 430

Query: 202 QQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKA--AFPPPEQKTAFDK 259
            +     + P +   P    A  A     +AQ +T PT+P  Q    A PPP+Q      
Sbjct: 431 AKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQ-QTGPTKPPSQLPGPAKPPPQQ------ 483

Query: 260 KLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPA--AASPPPPQ 317
                      P   +   ++  +A   +    +  P P    PA  +P    ++ PP Q
Sbjct: 484 -----------PGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQ 532

Query: 318 APFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPT 373
            P G      QQP+  +       +P        P+      P   Q P  GL  T
Sbjct: 533 QP-GSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKT 587



 Score = 33.9 bits (76), Expect = 0.89
 Identities = 43/206 (20%), Positives = 71/206 (34%), Gaps = 23/206 (11%)

Query: 241 PSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVP---PA 297
           P +Q+   P P+Q+        D    D  P+++   + E    + +  P    P   P 
Sbjct: 210 PLQQQPPKPIPKQQGPGR----DPLQQDGTPKSISSQQPEK---IKSQPPGTGKPIQGPT 262

Query: 298 PTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQV 357
            T     A  P       PQ          +Q    + +++   +P +    + P+    
Sbjct: 263 QTPQTDHAKLPLQRDASRPQT---------KQADIVRGESV---KPSLPSPSKPPIQQPT 310

Query: 358 PLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEMEVE 417
           P  P  Q PG       P  P AQP     P  QQP       Q  P T KP  Q +   
Sbjct: 311 PGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQ-PPGTTKPPAQPLGPA 369

Query: 418 QPCIQEVKRHMSDNRKSRSRSASRSP 443
           +P  Q+       + +   ++ ++ P
Sbjct: 370 KPPAQQTGSEKPSSEQPGPKALAQPP 395



 Score = 33.9 bits (76), Expect = 0.89
 Identities = 16/39 (41%), Positives = 17/39 (43%), Gaps = 7/39 (17%)

Query: 920  QPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQP 958
            QPP  P   P P  P  P       PPP   PPPT  +P
Sbjct: 2404 QPPPPPPPPPPPPPPPPP-------PPPPPLPPPTSPKP 2435



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 56/285 (19%), Positives = 97/285 (34%), Gaps = 31/285 (10%)

Query: 118 QKNGVFKIEIIQPLLDMAAGTSNAAPVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAV 177
           Q+ G  K    QP     +   +  PV++  +     PP     + +PP+Q  P ++   
Sbjct: 532 QQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTI--C 589

Query: 178 PQLPSSDAFAAV---AQLFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQ---AIT 231
           P   +++    V   A     T+ Q     L  F   P P    +   +    Q   A+ 
Sbjct: 590 PLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFN--PNPHLTEVKEWLCLNCQMKRALG 647

Query: 232 AQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAV--TTTA 289
             L   P+ P + K    P    +A  K           P+  + S K+D       + A
Sbjct: 648 GDLAPVPSSP-QPKLKTAPVTTTSAVSK---------SSPQPQQTSPKKDAAPKQDLSKA 697

Query: 290 PAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQ 349
           P    PP          +P+A +  PP+A      D + +PA  +  ++   Q +     
Sbjct: 698 PEPKKPPPLVKQPTLHGSPSAKAKQPPEA------DSLSKPAPPKEPSVPSEQDKAPVAD 751

Query: 350 QDPMHHQVPLPPNGQMPGFGLLPTPPFPP---MAQPVIPPTPPVQ 391
             P   ++  P    +        P  P     +Q     TPP++
Sbjct: 752 DKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLK 796



 Score = 32.7 bits (73), Expect = 2.0
 Identities = 35/179 (19%), Positives = 77/179 (43%), Gaps = 31/179 (17%)

Query: 924  QPQQQPQPQAPQQPQQQQQQQP---------PPSQQPPPTQQQPQQFRNDNRQQFNSGRD 974
            + + QP   +P+QP+ Q++ Q             +     +++   F+ D++Q   S +D
Sbjct: 1433 EKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKD 1492

Query: 975  QERFGRRSFGNRVENDRERYGNRNDDRDNSNRDRREWGRRSPDRDRHRDLEERNRRSS-- 1032
             +   +  F + +   RE Y +  +  ++ N         SP       + +R RR+S  
Sbjct: 1493 HKE--KSEFVDDITTRREPYDSVEESSESEN---------SP-------VPQRKRRTSVG 1534

Query: 1033 GHRDRERDSRDRESRREKEEARGKEKPEVT--DRAGGNKTVEPPISQVGNVDTASELEK 1089
                 E    D +   E+E+   K+  E++  + A G++  E   +Q+  + +++E +K
Sbjct: 1535 SSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQK 1593


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 105/360 (29%), Positives = 125/360 (34%), Gaps = 58/360 (16%)

Query: 623 SDTLNPDWKGIPKKPENEVAQNGGAETSHTEPVSPIPKPLPVPV-PPIPVPAPITVPPPQ 681
           + T   D   +P + +    Q   A+    E V P    LP P  PPI  P P   PP Q
Sbjct: 262 TQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKP---SLPSPSKPPIQQPTP-GKPPAQ 317

Query: 682 VPPH---QPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPGF 738
            P H   QPGP    A QP   T PL   P    P V PP    P               
Sbjct: 318 QPGHEKSQPGPAKPPA-QPSGLTKPLAQQPGTVKPPVQPPGTTKP--------------- 361

Query: 739 LPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTP 798
            P  P  P  PP        P    P   + A+         +  G A PP      P P
Sbjct: 362 -PAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKP 420

Query: 799 PVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRP 858
              QP   L +   APGP        T +    PG IP Q+         Q  P  PP  
Sbjct: 421 LAQQPG--LQSPAKAPGPT------KTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQ 472

Query: 859 MPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGG-MPGLGGPGPGPGGPEDRDG 917
           +P       PPP   G A PPP   + P     P  +PG   P    PGP    P+    
Sbjct: 473 LPGPAK---PPPQQPGPAKPPP---QQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGS 526

Query: 918 RQQPPQQP------QQQPQPQAPQQPQQQ---------QQQQPP---PSQQPPPTQQQPQ 959
            + P QQP       QQP P  P   Q           +  QPP   PS + PP+Q  P+
Sbjct: 527 TKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPK 586



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 100/349 (28%), Positives = 119/349 (34%), Gaps = 75/349 (21%)

Query: 660 KPLPVPVPPI----PVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGV 715
           KP  +  PP+    P P P    P + P  Q G P   + Q P     +   PPG G  +
Sbjct: 202 KPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPE---KIKSQPPGTGKPI 258

Query: 716 PPPPPPP-------PFLRPGFNPMHLPPGFL-----PPGPPPPITPPVSIPPPHTPPISI 763
             P   P       P  R    P       +      P  P P  PP+  P P  PP   
Sbjct: 259 QGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQ 318

Query: 764 PNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQP------VSLLGT-----QGV 812
           P            G      G A PPA P+ L  P   QP      V   GT     Q +
Sbjct: 319 P------------GHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPL 366

Query: 813 APGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGP 872
            P      Q  S      +PG   L +PPG+      + P   P P  P     G P   
Sbjct: 367 GPAKPPAQQTGSEKPSSEQPGPKALAQPPGVG-----KTPAQQPGPAKPPTQQVGTPKP- 420

Query: 873 GGFAMPPPHGMKGPFPPHGPFVRPGGMPGLG-------GPGP------GPGGPEDR-DGR 918
              A  P  G++ P    GP   P   PG G       GPG       GP  P  +  G 
Sbjct: 421 --LAQQP--GLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGP 476

Query: 919 QQPPQQ-------PQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQPQQ 960
            +PP Q       P QQP    P  P QQ     PP QQP P +  PQQ
Sbjct: 477 AKPPPQQPGPAKPPPQQPGSAKP--PSQQPGSTKPPPQQPGPAKPSPQQ 523



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 48/171 (28%), Positives = 61/171 (35%), Gaps = 28/171 (16%)

Query: 655  VSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPV---------------------VG 693
            +S  P P P P PP P P P   PPP  PP  P P +                     V 
Sbjct: 2401 ISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVT 2460

Query: 694  ALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRP-GFNPMHLPPGFLPPGPPPPITP--P 750
             L+  A     G+P        PPP PP P   P G    H P    PP  P P+ P  P
Sbjct: 2461 TLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLP 2520

Query: 751  VSIPPP---HTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTP 798
             +   P   H  P  + +L S    N  +    K+     P +  +N  +P
Sbjct: 2521 TTTQKPTDIHPKPTGL-SLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSP 2570



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 72/328 (21%), Positives = 110/328 (33%), Gaps = 49/328 (14%)

Query: 143 PVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQ 202
           P+ ++ T    S   P K+ S+PP    P   P                  QT Q    +
Sbjct: 229 PLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPT-----------------QTPQTDHAK 271

Query: 203 QILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLL 262
             LQ  +   +PQ+   D   + + +++   L +    P +Q     PP Q+   +K   
Sbjct: 272 LPLQ--RDASRPQTKQAD---IVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQP 326

Query: 263 DRFDYDDEPEAVEESKKEDTTAV--------TTTAPAAAVPPAPTATVPAAAAPAAASPP 314
                  +P  + +   +    V        TT  PA  + PA        +   ++  P
Sbjct: 327 GPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQP 386

Query: 315 PPQAPFGFPGDGM---QQPAYTQHQNMDQFQPRMMGIQ---QDPMHHQVPLPPNGQMPGF 368
            P+A    PG G    QQP   +        P+ +  Q   Q P     P     Q PG 
Sbjct: 387 GPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGP 446

Query: 369 GLLP-------------TPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEME 415
           G +P             T P  P +Q   P  PP QQP  A    Q     + P QQ   
Sbjct: 447 GKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGS 506

Query: 416 VEQPCIQEVKRHMSDNRKSRSRSASRSP 443
            + P  Q      S  +   ++  S+ P
Sbjct: 507 TKPPPQQPGPAKPSPQQPGSTKPPSQQP 534



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 50/175 (28%), Positives = 64/175 (36%), Gaps = 19/175 (10%)

Query: 709  PGFGPGVPP-PPPPPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNLV 767
            P   P V   P  P PF R     +   P   PP PPPP  PP   PPP  PP + P   
Sbjct: 2377 PSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPT 2436

Query: 768  SGARGNAESGDSVKMYGSAVPP-AAPTNLPTPPVTQ----PVSLLGTQGVAPGPVIGLQA 822
               +        V    +A P   A T L T  V +    PV+ + T    P P      
Sbjct: 2437 ILPKKKLTVASPVT---TATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSI 2493

Query: 823  PSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAM 877
            PS  +   RP      +PP  P P + + P    +P   H       P P G ++
Sbjct: 2494 PSGLVFTHRP---EPSKPPIAPKPVIPQLPTTTQKPTDIH-------PKPTGLSL 2538



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 87/411 (21%), Positives = 124/411 (30%), Gaps = 90/411 (21%)

Query: 626  LNPDWKGIPKKPENEVAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPP- 684
            L  D   +P  P+ ++       TS     SP P+         P       P P+ PP 
Sbjct: 646  LGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPP 705

Query: 685  --HQP---GPPVVGALQPPAFTPPLGIPPPGFGPGVPPP----------PPPPPFLRPGF 729
               QP   G P   A QPP     L  P P   P VP            P  P  ++P  
Sbjct: 706  LVKQPTLHGSPSAKAKQPPE-ADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTT 764

Query: 730  NPMHLPPGFLPPGPP-------------PPITPPVSIPPPHTPPI----------SIPNL 766
            + +        P  P             PP+    + P    PP           +IP  
Sbjct: 765  DLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRP 824

Query: 767  VSGARGNAESGDSVKMYGSAV---------PPAAPTNLPTPPVTQPVSLLGTQGVAPGPV 817
             S ++  +  G S +  G            P  A T +   P  +P+         P P 
Sbjct: 825  ASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPT 884

Query: 818  IGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLM--------PPRPMPPHMMHRGPP 869
             G   P+           P Q P   P    +RF L           +P  P     G  
Sbjct: 885  AGQTVPT-----------PQQSPK--PQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKL 931

Query: 870  PGPGGF------------AMPPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDG 917
             G G                P PH   GP  P      P   P   GP    G       
Sbjct: 932  FGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPA 991

Query: 918  RQQPPQQPQQQP-----QPQAPQQP---QQQQQQQPPPSQQPPPTQQQPQQ 960
            +  P ++  + P     +P+A Q P   + + +++PPP +       +PQ+
Sbjct: 992  KSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQK 1042



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 79/346 (22%), Positives = 121/346 (34%), Gaps = 59/346 (17%)

Query: 153  GSPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVA--QLFQTTQGQQLQQILQTFQQ 210
            GSP    K   E  + + P + P  P +PS    A VA  +  Q    +    ++ +   
Sbjct: 714  GSPSAKAKQPPEADSLSKP-APPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSA 772

Query: 211  PPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTA-FDKKLLDRFDYDD 269
              KP  P+      A+ +  T  LKT   +PS+   +FPP  +K + FD K + R   D 
Sbjct: 773  TTKPDIPSSKVQSQAE-EKTTPPLKTDSAKPSQ---SFPPTGEKVSPFDSKAIPRPASDS 828

Query: 270  E----PEAVEESK-----------KEDTTAVTTTAP---------AAAVPPAPTATVPAA 305
            +    P    ESK           +E   A T  +P          +  PP P  T    
Sbjct: 829  KIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQT 888

Query: 306  AAPAAASPPPPQAPFGFP---GDGMQQPAYTQHQNMDQFQPRMMGI-------------- 348
                  SP P +    F    G     P        +    ++ G               
Sbjct: 889  VPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLIST 948

Query: 349  --QQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTP----PVQQPFQASFQAQN 402
              Q  P     P  P  Q P     PT   PP +    PP P    PV++  +A    + 
Sbjct: 949  AGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKL 1008

Query: 403  EPLTQKP---HQQEMEVEQPCIQEVKRHMSDNRKS-RSRSASRSPK 444
            EP  ++     + E E + P I++ K   ++ +K+       +SPK
Sbjct: 1009 EPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPK 1054



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 57/212 (26%), Positives = 76/212 (35%), Gaps = 58/212 (27%)

Query: 633  IPKKPENEVAQNGGAETSHTE-PVSPIPKPLP----VPVPPIPV----PAPITVPPPQVP 683
            +P K +         ET   E P S +P   P    +P  P P        I+  PP  P
Sbjct: 2350 LPMKEQLSTTYFTSGETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPP 2409

Query: 684  PHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGP 743
            P  P PP                PPP      PPPPPPP           LPP   P  P
Sbjct: 2410 PPPPPPP----------------PPP------PPPPPPP-----------LPP---PTSP 2433

Query: 744  PPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMYG---SAVPPAAPTNLPTPPV 800
             P I P   +      P++    +  A    E+   ++  G   + +   AP  +P  P 
Sbjct: 2434 KPTILPKKKLTV--ASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPS 2491

Query: 801  TQPVSLLGTQ-------GVAPGPVIGLQAPST 825
            + P  L+ T         +AP PVI  Q P+T
Sbjct: 2492 SIPSGLVFTHRPEPSKPPIAPKPVIP-QLPTT 2522



 Score = 38.1 bits (87), Expect = 0.047
 Identities = 49/204 (24%), Positives = 63/204 (30%), Gaps = 49/204 (24%)

Query: 788  PPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPH 847
            PP++   LP          L T     G   G + P++ L    P +  L   P  P P 
Sbjct: 2343 PPSSVIALPMK------EQLSTTYFTSGETFGQEKPASQLPSGSPSVSSL---PAKPRPF 2393

Query: 848  LQRFPL----MPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPF---------- 893
             +   L     PP P PP      PPP P    +PPP   K    P              
Sbjct: 2394 FRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTAT 2453

Query: 894  --------------VRPGGMP----GLGGPGPGPGGPEDRDG-----RQQPPQQPQQQPQ 930
                          +R  G+P        P P P  P           +  P +P   P+
Sbjct: 2454 PLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPK 2513

Query: 931  PQAPQQPQQQQQQQPPPSQQPPPT 954
            P  PQ P   Q+   P    P PT
Sbjct: 2514 PVIPQLPTTTQK---PTDIHPKPT 2534



 Score = 37.0 bits (84), Expect = 0.11
 Identities = 38/149 (25%), Positives = 53/149 (35%), Gaps = 31/149 (20%)

Query: 269  DEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQ 328
            + P    +++        T   +  VPP    T    ++PA     P QAP         
Sbjct: 3854 ERPRTAPQTEFSQFIPPQTQTESQLVPPTSPYTQYQYSSPAL----PTQAP--------- 3900

Query: 329  QPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTP 388
              +YTQ  + +Q         Q   H QV   P    P F  + T  F P  QP   P P
Sbjct: 3901 -TSYTQQSHFEQ---------QTLYHQQVS--PYQTQPTFQAVATMSFTPQVQPTPTPQP 3948

Query: 389  PVQQPFQASFQAQNEPLTQKPHQQEMEVE 417
              Q P      +Q   + QKP Q  + +E
Sbjct: 3949 SYQLP------SQMMVIQQKPRQTTLYLE 3971



 Score = 36.6 bits (83), Expect = 0.14
 Identities = 98/446 (21%), Positives = 130/446 (29%), Gaps = 128/446 (28%)

Query: 634 PKKPENEVAQNGGAETSHTEPVSPIPKPL-PVPVPPIPVPAPITVPPPQVP------PHQ 686
           P KP  +  Q G A+    +P S  P P  P P  P P     T PP Q P        Q
Sbjct: 486 PAKPPPQ--QPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQ 543

Query: 687 PGPPVVGALQPPAFTPPLG----IPPPGFGPGVPPPPPP--PPFLRPGFNP----MHLPP 736
           P P    A Q        G    + PP   P    PP    P  + P  N     +H+P 
Sbjct: 544 PSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPE 603

Query: 737 ------------------GFLPPGPPPPIT---------------------PPVSIPPPH 757
                             GF    P P +T                     P  S P P 
Sbjct: 604 KANFNTCTECQTTVCSLCGF---NPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPK 660

Query: 758 --TPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPG 815
             T P++  + VS +    +     K    A P    +  P P    P+    T   +P 
Sbjct: 661 LKTAPVTTTSAVSKSSPQPQQTSPKK---DAAPKQDLSKAPEPKKPPPLVKQPTLHGSPS 717

Query: 816 PVIGLQAPSTGLLGARPGLIPLQRPPGMP--PPHLQRFPLMPPRPMPPHMM--------- 864
                Q P    L ++P       PP  P  P    + P+   +P  P M+         
Sbjct: 718 AK-AKQPPEADSL-SKPA------PPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSS 769

Query: 865 -------------------HRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGP 905
                               +  PP     A P        FPP G  V P     +  P
Sbjct: 770 SSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQS-----FPPTGEKVSPFDSKAIPRP 824

Query: 906 G--------PGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQPP---PT 954
                    PGP        +  P Q+ ++  + Q    P+   +  P  S  PP   PT
Sbjct: 825 ASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPT 884

Query: 955 --------QQQPQQFRNDNRQQFNSG 972
                   QQ P+      R   N G
Sbjct: 885 AGQTVPTPQQSPKPQEQSRRFSLNLG 910



 Score = 35.4 bits (80), Expect = 0.31
 Identities = 75/358 (20%), Positives = 127/358 (35%), Gaps = 61/358 (17%)

Query: 118  QKNGVFKIEIIQPLLDMAAGTSNAAPVAENVTNNEGSPPPP------------VKVSSEP 165
            +  G  +++ +Q   +     +  +P  +     +GSP PP             + S +P
Sbjct: 839  ESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKP 898

Query: 166  PTQA------------TPNSVPAVPQ-LPSSDAFAAVAQLFQTTQGQQLQQILQTFQQPP 212
              Q+             P S P  PQ   +   F   A +F      Q   ++ T  Q P
Sbjct: 899  QEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIF-----SQASNLISTAGQ-P 952

Query: 213  KPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPP--------EQKTAFDKKLLDR 264
             P S +   A M Q  A  +Q  T+   P     A P P        E K    +KL  +
Sbjct: 953  GPHSQSGPGAPMKQAPA-PSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPK 1011

Query: 265  FDYDDEPEAVEESKK----EDTTAVTTTAPAAAVP------PAPTATVPAAAAPAAASPP 314
             +     +  E  KK    +D+ ++T     A +P      P P +T P           
Sbjct: 1012 AEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSK 1071

Query: 315  PPQAPFGFPGDGMQQPAYTQHQNMDQFQ--PRMMGIQQ-DPMHHQVPLPPNGQMPGFGLL 371
             P      P          Q  N+  F   P +  IQ+   ++ Q     +GQ+     +
Sbjct: 1072 DP------PNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKM 1125

Query: 372  PTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEMEVEQPCIQEVKRHMS 429
            P  P  P A P+  PT    Q  + +   Q + + ++  + + E E+  +++VK  +S
Sbjct: 1126 PPAPSGPKASPMPVPTESSSQ--KTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLS 1181



 Score = 34.7 bits (78), Expect = 0.52
 Identities = 53/236 (22%), Positives = 78/236 (33%), Gaps = 25/236 (10%)

Query: 143 PVAENVTNNEGSPPPPVKVSSEPP-TQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQL 201
           P  +  +    S  P  K  ++PP    TP   P  P  P +        L Q    Q  
Sbjct: 372 PAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPG-PAKPPTQQVGTPKPLAQQPGLQSP 430

Query: 202 QQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKA--AFPPPEQKTAFDK 259
            +     + P +   P    A  A     +AQ +T PT+P  Q    A PPP+Q      
Sbjct: 431 AKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQ-QTGPTKPPSQLPGPAKPPPQQ------ 483

Query: 260 KLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPA--AASPPPPQ 317
                      P   +   ++  +A   +    +  P P    PA  +P    ++ PP Q
Sbjct: 484 -----------PGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQ 532

Query: 318 APFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPT 373
            P G      QQP+  +       +P        P+      P   Q P  GL  T
Sbjct: 533 QP-GSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKT 587



 Score = 33.9 bits (76), Expect = 0.89
 Identities = 43/206 (20%), Positives = 71/206 (34%), Gaps = 23/206 (11%)

Query: 241 PSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVP---PA 297
           P +Q+   P P+Q+        D    D  P+++   + E    + +  P    P   P 
Sbjct: 210 PLQQQPPKPIPKQQGPGR----DPLQQDGTPKSISSQQPEK---IKSQPPGTGKPIQGPT 262

Query: 298 PTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQV 357
            T     A  P       PQ          +Q    + +++   +P +    + P+    
Sbjct: 263 QTPQTDHAKLPLQRDASRPQT---------KQADIVRGESV---KPSLPSPSKPPIQQPT 310

Query: 358 PLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEMEVE 417
           P  P  Q PG       P  P AQP     P  QQP       Q  P T KP  Q +   
Sbjct: 311 PGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQ-PPGTTKPPAQPLGPA 369

Query: 418 QPCIQEVKRHMSDNRKSRSRSASRSP 443
           +P  Q+       + +   ++ ++ P
Sbjct: 370 KPPAQQTGSEKPSSEQPGPKALAQPP 395



 Score = 33.9 bits (76), Expect = 0.89
 Identities = 16/39 (41%), Positives = 17/39 (43%), Gaps = 7/39 (17%)

Query: 920  QPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQP 958
            QPP  P   P P  P  P       PPP   PPPT  +P
Sbjct: 2404 QPPPPPPPPPPPPPPPPP-------PPPPPLPPPTSPKP 2435



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 56/285 (19%), Positives = 97/285 (34%), Gaps = 31/285 (10%)

Query: 118 QKNGVFKIEIIQPLLDMAAGTSNAAPVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAV 177
           Q+ G  K    QP     +   +  PV++  +     PP     + +PP+Q  P ++   
Sbjct: 532 QQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTI--C 589

Query: 178 PQLPSSDAFAAV---AQLFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQ---AIT 231
           P   +++    V   A     T+ Q     L  F   P P    +   +    Q   A+ 
Sbjct: 590 PLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFN--PNPHLTEVKEWLCLNCQMKRALG 647

Query: 232 AQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAV--TTTA 289
             L   P+ P + K    P    +A  K           P+  + S K+D       + A
Sbjct: 648 GDLAPVPSSP-QPKLKTAPVTTTSAVSK---------SSPQPQQTSPKKDAAPKQDLSKA 697

Query: 290 PAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQ 349
           P    PP          +P+A +  PP+A      D + +PA  +  ++   Q +     
Sbjct: 698 PEPKKPPPLVKQPTLHGSPSAKAKQPPEA------DSLSKPAPPKEPSVPSEQDKAPVAD 751

Query: 350 QDPMHHQVPLPPNGQMPGFGLLPTPPFPP---MAQPVIPPTPPVQ 391
             P   ++  P    +        P  P     +Q     TPP++
Sbjct: 752 DKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLK 796



 Score = 32.7 bits (73), Expect = 2.0
 Identities = 35/179 (19%), Positives = 77/179 (43%), Gaps = 31/179 (17%)

Query: 924  QPQQQPQPQAPQQPQQQQQQQP---------PPSQQPPPTQQQPQQFRNDNRQQFNSGRD 974
            + + QP   +P+QP+ Q++ Q             +     +++   F+ D++Q   S +D
Sbjct: 1433 EKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKD 1492

Query: 975  QERFGRRSFGNRVENDRERYGNRNDDRDNSNRDRREWGRRSPDRDRHRDLEERNRRSS-- 1032
             +   +  F + +   RE Y +  +  ++ N         SP       + +R RR+S  
Sbjct: 1493 HKE--KSEFVDDITTRREPYDSVEESSESEN---------SP-------VPQRKRRTSVG 1534

Query: 1033 GHRDRERDSRDRESRREKEEARGKEKPEVT--DRAGGNKTVEPPISQVGNVDTASELEK 1089
                 E    D +   E+E+   K+  E++  + A G++  E   +Q+  + +++E +K
Sbjct: 1535 SSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQK 1593


>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
           sapiens]
          Length = 483

 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 91/314 (28%), Positives = 110/314 (35%), Gaps = 77/314 (24%)

Query: 665 PVPPIPVPAPITVPPPQVPPHQPG----PPVVGALQPPAFTPPLGIPPPGFGPGVPPPPP 720
           P P +P     T+  P +PP  P         GA +     P +  PPP   P  PPP P
Sbjct: 131 PSPRLPNK---TISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPLP 187

Query: 721 PP-PFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDS 779
           PP P   P   P+  PPG L  G  P + PPV   PP  PP                   
Sbjct: 188 PPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPP------------------- 228

Query: 780 VKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQR 839
                   PP      PTPP   P S+L  + V                  +P L PL  
Sbjct: 229 --------PPP-----PTPPPLPPASVLSDKAV------------------KPQLAPLHL 257

Query: 840 PPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGM 899
           PP +PPP     PL+PP   P     +  P  P   A  PP     P PP  P+      
Sbjct: 258 PP-IPPP----LPLLPPCGYPGL---KAEPASPAQDAQEPP----APPPPLPPYASCSPR 305

Query: 900 PGLGGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQPQ 959
             L    P P  P      + PP  P + P  QAP Q    Q    PP+   PP  Q   
Sbjct: 306 ASL----PAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPA---PPGSQPFL 358

Query: 960 QFRNDNRQQFNSGR 973
           Q +   R     G+
Sbjct: 359 QKKRHGRPGAGGGK 372



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 94/338 (27%), Positives = 117/338 (34%), Gaps = 94/338 (27%)

Query: 639 NEVAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPP--HQPGPPVVGALQ 696
           N    +G A T+   P  P P P   P PP P+P P+    P   P    PGP   G L 
Sbjct: 154 NTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNL- 212

Query: 697 PPAFTPPLGIPPPGFGPGVPPPPPPPP--------FLRPGFNPMHLPPGFLPPGPPPPIT 748
            P   PP+   PP   P  PP PPP P         ++P   P+HLPP  +PP       
Sbjct: 213 -PVVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPP--IPP------- 262

Query: 749 PPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLG 808
                P P  PP   P L +     A+            PPA P  LP      P +   
Sbjct: 263 -----PLPLLPPCGYPGLKAEPASPAQDAQE--------PPAPPPPLP------PYASCS 303

Query: 809 TQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGP 868
            +   P P +             PG+      P             PP P P     + P
Sbjct: 304 PRASLPAPPL-------------PGVNSSSETP-------------PPLP-PKSPSFQAP 336

Query: 869 PPGPGGFAMPPPHGMKGPFPPHG-PFV--RPGGMPGLGGPGPGPGGPEDRDGRQQPPQQP 925
           P   G  A+P P     P PP   PF+  +  G PG GG    P           PP  P
Sbjct: 337 PQKAGAQALPAP-----PAPPGSQPFLQKKRHGRPGAGGGKLNP-----------PPAPP 380

Query: 926 QQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQPQQFRN 963
            + P  +   + QQ        +    PTQQ   Q RN
Sbjct: 381 ARSPTTELSSKSQQ--------ATAWTPTQQPGGQLRN 410



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 97/354 (27%), Positives = 115/354 (32%), Gaps = 71/354 (20%)

Query: 657 PIPKPLPVPVPPIPVPAPITVPPPQVPP--------HQPGPPVVGAL------------- 695
           P P PLP P PP+  P P   PPP  PP         +  P    AL             
Sbjct: 6   PPPPPLPPPPPPLGAPPP---PPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKV 62

Query: 696 ------QPPAFTPPLGIPPPGFGP----GVPPPPPPPPFLRPGFNPMHLPPGFLP----- 740
                   P      G    G G     G   PP        GF P+  P G        
Sbjct: 63  TQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGF-PVLRPAGQRDVAGGK 121

Query: 741 ----PG--PPPPITPPVSIPPPHTPPISIPNL--VSGARGNAESGDSVKMYGSAVPPAAP 792
               PG   P P  P  +I  P  PP S P L   S A G A +        +  PP  P
Sbjct: 122 TGQGPGSRAPSPRLPNKTISGPLIPPAS-PRLGNTSEAHGAARTAPPRPNVPAPPPPTPP 180

Query: 793 TNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPST-GLLGARPGLIPLQRPPGMPPPHLQRF 851
              P PP+  P   L +      P++    P T G L      +P   PP  PPP     
Sbjct: 181 P--PPPPLPPP---LPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPP----- 230

Query: 852 PLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGG 911
           P  PP P+PP  +       P    + P H    P PP  P + P G PGL      P  
Sbjct: 231 PPTPP-PLPPASVLSDKAVKP---QLAPLH--LPPIPPPLPLLPPCGYPGLKAEPASPAQ 284

Query: 912 PEDRDGRQQPPQQPQQQPQPQA-----PQQPQQQQQQQPPPSQQPPPTQQQPQQ 960
                    PP  P     P+A     P        + PPP     P+ Q P Q
Sbjct: 285 DAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQ 338



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 73/306 (23%), Positives = 97/306 (31%), Gaps = 84/306 (27%)

Query: 141 AAPVAENVTNNEGSP---PPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAA--VAQLFQT 195
           A+P   N +   G+    PP   V + PP    P   P  P LPSS       V+     
Sbjct: 148 ASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPL 207

Query: 196 TQGQQLQQILQTF-------QQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAF 248
           T+G  L  +             PP P  P L  A +   +A+  QL      P       
Sbjct: 208 TKG-NLPVVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPP------I 260

Query: 249 PPPEQKTAFDKKLLDRFDYDD---EPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVP-- 303
           PPP         LL    Y     EP +  +  +E              PPAP   +P  
Sbjct: 261 PPP-------LPLLPPCGYPGLKAEPASPAQDAQE--------------PPAPPPPLPPY 299

Query: 304 AAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNG 363
           A+ +P A+ P PP      PG        +  +      P+    Q  P           
Sbjct: 300 ASCSPRASLPAPP-----LPG------VNSSSETPPPLPPKSPSFQAPP----------- 337

Query: 364 QMPGFGLLPTPPFPPMAQPVI-----------------PPTPPVQQPFQASFQAQNEPLT 406
           Q  G   LP PP PP +QP +                 PP PP + P         +   
Sbjct: 338 QKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQATA 397

Query: 407 QKPHQQ 412
             P QQ
Sbjct: 398 WTPTQQ 403



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 44/175 (25%), Positives = 55/175 (31%), Gaps = 26/175 (14%)

Query: 214 PQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEA 273
           P SP L N   A   A TA  +  P  P+      PPP                   P  
Sbjct: 147 PASPRLGNTSEAHGAARTAPPR--PNVPAPPPPTPPPPPPPL---------------PPP 189

Query: 274 VEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYT 333
           +  S    T  V+   P       P    P   AP    PPPP  P   P      PA  
Sbjct: 190 LPSSSPIKTPLVSPPGPLTK-GNLPVVAPPVPCAPPPPPPPPPPTPPPLP------PASV 242

Query: 334 QHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTP 388
                   +P++  +   P+   +PL P    PG    P  P     +P  PP P
Sbjct: 243 LSDKA--VKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPP 295



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 65/289 (22%), Positives = 84/289 (29%), Gaps = 55/289 (19%)

Query: 155 PPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPKP 214
           PPPP+     PP  A P S      L  +D     A L    QG +L+++ Q   +    
Sbjct: 14  PPPPLGAPPPPPPSAPPVSTDT-SSLRRADPKGRSALLADIQQGTRLRKVTQINDRSAPQ 72

Query: 215 QSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFP---PPEQKTAFDKKLLDRFDYDDEP 271
              +          A T    T PT        FP   P  Q+     K          P
Sbjct: 73  IESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGGKT------GQGP 126

Query: 272 EAVEESKKEDTTAV--------------TTTAPAAAVPPAPTATVPAAAAPAAASPPPPQ 317
            +   S +     +              T+ A  AA    P   VPA   P    PPPP 
Sbjct: 127 GSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPL 186

Query: 318 APFGFPGDG------MQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLL 371
            P   P         +  P      N+    P             VP  P          
Sbjct: 187 PP-PLPSSSPIKTPLVSPPGPLTKGNLPVVAP------------PVPCAP---------- 223

Query: 372 PTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEMEVEQPC 420
             PP PP   P  PP PP       + + Q  PL   P    + +  PC
Sbjct: 224 --PPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPC 270


>gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]
          Length = 2217

 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 96/333 (28%), Positives = 115/333 (34%), Gaps = 63/333 (18%)

Query: 654 PVSPIPKPLPVPVPPIPVPAPI-----TVPPPQVP-PHQPGPPVVGALQPPAFTPPLGIP 707
           PV  +P P   P      P P       +PPP  P P  PG P     QPP    P  +P
Sbjct: 682 PVGSVPAPACPPSLQQHFPDPAMSFAPVLPPPSTPMPTGPGQPAPPGQQPPPLAQPTPLP 741

Query: 708 ----PPGFGPGVPPPPPPPPFLRPGFN---PMHLPPGFLPPGP------PPPITPPVSIP 754
               P    P  P PP  PP+L P      P  L P  +P  P       PP  PP+ + 
Sbjct: 742 QVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQVPPQMPPIPVV 801

Query: 755 PPHTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPT---PPVTQPVSLLGTQG 811
           PP TP   I  L                     PPA P +LPT   PPV  P        
Sbjct: 802 PPITPLAGIDGL---------------------PPALP-DLPTATVPPVPPPQYF----- 834

Query: 812 VAPGPVIGLQAPSTGLLGARPGL----IPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRG 867
               P + L + +  L  A P L    + L  PPG P     R  ++P  P    ++   
Sbjct: 835 ---SPAVILPSLAAPLPPASPALPLQAVKLPHPPGAPLAMPCR-TIVPNAPATIPLLAVA 890

Query: 868 PPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQPQQ 927
           PP    G A    H      P  G  V P   P +      P         +  P QP  
Sbjct: 891 PP----GVAALSIHSAVAQLP--GQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPPQPAL 944

Query: 928 QPQPQAPQQPQQQQQQQPPPSQQPPPTQQQPQQ 960
            PQP  P QP    Q   PP    PP   +P Q
Sbjct: 945 PPQPTLPPQPVLPPQPTLPPQPVLPPQPTRPPQ 977



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 99/342 (28%), Positives = 124/342 (36%), Gaps = 76/342 (22%)

Query: 654  PVSPIPKPLPVPVPP--------IPVPAPITVPPPQVPPHQPGPP-------VVGALQPP 698
            P +P+P     P PP         P P P  + P  V P QP PP           +  P
Sbjct: 713  PSTPMPTGPGQPAPPGQQPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLAPASQVGAP 772

Query: 699  AFTPPLGIPPPGFGP--GVPPPPPPPPFLRPGFNPM----HLPPGFLPPGPPPPITPPVS 752
            A   PL +P     P   VPP  PP P + P   P+     LPP    P  P    PPV 
Sbjct: 773  AQLKPLQMPQAPLQPLAQVPPQMPPIPVV-PPITPLAGIDGLPPAL--PDLPTATVPPVP 829

Query: 753  IPPPHTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAP------TNLPTP---PVTQP 803
             P   +P + +P+L                  + +PPA+P        LP P   P+  P
Sbjct: 830  PPQYFSPAVILPSL-----------------AAPLPPASPALPLQAVKLPHPPGAPLAMP 872

Query: 804  VSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHM 863
               +     A  P++ +  P    L     +  L   PG  P +   FP M P  +PP  
Sbjct: 873  CRTIVPNAPATIPLLAVAPPGVAALSIHSAVAQL---PGQ-PVYPAAFPQMAPTDVPPSP 928

Query: 864  MH-----RGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDGR 918
             H     R  PP P   A+PP      P  P  P + P   P L    P P  P      
Sbjct: 929  HHTVQNMRATPPQP---ALPPQ-----PTLPPQPVLPP--QPTL---PPQPVLPPQPTRP 975

Query: 919  QQP--PQQPQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQP 958
             QP  P QP   PQP  P  PQ     +P P Q   P Q  P
Sbjct: 976  PQPVLPPQPMLPPQPVLP--PQPALPVRPEPLQPHLPEQAAP 1015



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 116/448 (25%), Positives = 161/448 (35%), Gaps = 103/448 (22%)

Query: 653  EPVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQ-PGPPVVGALQPPAFTPPLGIPPP-- 709
            +PV P+ +P+P  +PP   PA     P Q+ P Q P  P+    Q P   PP+ + PP  
Sbjct: 747  QPVVPL-QPVPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQVPPQMPPIPVVPPIT 805

Query: 710  ------GFGPGVP-------PPPPPPPFLRPGFNPMHLPPGFLPPGPP-PPITPPVSIPP 755
                  G  P +P       PP PPP +    F+P  + P    P PP  P  P  ++  
Sbjct: 806  PLAGIDGLPPALPDLPTATVPPVPPPQY----FSPAVILPSLAAPLPPASPALPLQAVKL 861

Query: 756  PHTP---------------PISIPNLVSGARGNAESG--------DSVKMYGSAVPPAAP 792
            PH P               P +IP L     G A               +Y +A P  AP
Sbjct: 862  PHPPGAPLAMPCRTIVPNAPATIPLLAVAPPGVAALSIHSAVAQLPGQPVYPAAFPQMAP 921

Query: 793  TNLPTPP--------VTQPVSLLGTQ-GVAPGPVIGLQ--APSTGLLGARPGLIP---LQ 838
            T++P  P         T P   L  Q  + P PV+  Q   P   +L  +P   P   L 
Sbjct: 922  TDVPPSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQPTLPPQPVLPPQPTRPPQPVLP 981

Query: 839  RPPGMPP-PHLQRFPLMP--PRPMPPHMMHRGPP---PG-------PGGFA--------- 876
              P +PP P L   P +P  P P+ PH+  +  P   PG       P  +A         
Sbjct: 982  PQPMLPPQPVLPPQPALPVRPEPLQPHLPEQAAPAATPGSQILLGHPAPYAVDVAAQVPT 1041

Query: 877  --MPPPHGMKGPFP----PHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQP----- 925
              +PP   +  P P    P  P + P     L            +     PP  P     
Sbjct: 1042 VPVPPAAVLSPPLPEVLLPAAPELLPQFPSSLATVSASVQSVPTQTATLLPPANPPLPGG 1101

Query: 926  ----QQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQPQQFRNDNRQQFNSGRDQERFGRR 981
                   P  Q   +P Q++Q     SQ  PP    PQ   +       SG++       
Sbjct: 1102 PGIASPCPTVQLTVEPVQEEQ----ASQDKPP--GLPQSCESYGGSDVTSGKELSDSCEG 1155

Query: 982  SF-GNRVENDRERYGNRNDDRDNSNRDR 1008
            +F G R+E    R  +R   R  S ++R
Sbjct: 1156 AFGGGRLEGRAARKHHRRSTRARSRQER 1183



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 63/226 (27%), Positives = 82/226 (36%), Gaps = 31/226 (13%)

Query: 633  IPKKPENEVAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPVV 692
            +P  P + V QN  A    T P   +P    +P  P+  P P   P P +PP    PP  
Sbjct: 924  VPPSPHHTV-QNMRA----TPPQPALPPQPTLPPQPVLPPQPTLPPQPVLPPQPTRPP-Q 977

Query: 693  GALQPPAFTPPLGIPPPGFGPGVPPPPPP-PPFLRPGFNPMHLPPGFLPPGPPPPI---- 747
              L P    PP  + PP   P +P  P P  P L     P   P   +  G P P     
Sbjct: 978  PVLPPQPMLPPQPVLPP--QPALPVRPEPLQPHLPEQAAPAATPGSQILLGHPAPYAVDV 1035

Query: 748  ---TPPVSIPP-----PHTPPISIPNLVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPP 799
                P V +PP     P  P + +P           S  +V     +VP    T L  PP
Sbjct: 1036 AAQVPTVPVPPAAVLSPPLPEVLLPAAPELLPQFPSSLATVSASVQSVPTQTATLL--PP 1093

Query: 800  VTQPVSLLGTQGVA-PGPVIGLQAPSTGLLGARPGLIPLQRPPGMP 844
               P  L G  G+A P P + L          +       +PPG+P
Sbjct: 1094 ANPP--LPGGPGIASPCPTVQLTVEP-----VQEEQASQDKPPGLP 1132



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 66/264 (25%), Positives = 87/264 (32%), Gaps = 50/264 (18%)

Query: 654  PVSPIPKP-LPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFG 712
            PV+  P P  P   PP+P+ +   +PP       P    + + + P+F     +     G
Sbjct: 1317 PVAEHPAPEAPESSPPLPLSS---LPPEASQDSAPYKDQLSSKEQPSFLASQQLLSQA-G 1372

Query: 713  PGVPPPPPPPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNLVSGARG 772
            P  PP  PP P               L P  PP    P     P T  +  P        
Sbjct: 1373 PSNPPGAPPAP---------------LAPSSPPVTALPQDGAAPATSTMPEP-------- 1409

Query: 773  NAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARP 832
               SG + +  G   P    + L T   +QP++      +A  P++   AP T       
Sbjct: 1410 --ASGTASQAGGPGTPQGLTSELET---SQPLAETHEAPLAVQPLVVGLAPCT------- 1457

Query: 833  GLIPLQRPPGMPPPHLQRFPLMPPRPMP-PHMMHRGPPPGPGGFAMPPPHGMKG------ 885
               P             R PL PP P P PH     P  G     +P   G         
Sbjct: 1458 ---PAPEAASTRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLATSQL 1514

Query: 886  PFPPHGPFVRPGGMPGLGGPGPGP 909
            P PP GP V P     L   G GP
Sbjct: 1515 PSPPLGPTVPPQPPSALESDGEGP 1538



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 81/322 (25%), Positives = 108/322 (33%), Gaps = 35/322 (10%)

Query: 165  PPTQATPNSVPAVPQLPSSDAF-AAVAQLFQT----TQGQQLQQILQTFQQPPKPQSPAL 219
            PP  A  +   AV QLP    + AA  Q+  T    +    +Q +  T  QP  P  P L
Sbjct: 891  PPGVAALSIHSAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPPQPALPPQPTL 950

Query: 220  DNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKK 279
                +   Q         P QP+       PP+        L  +      PE ++    
Sbjct: 951  PPQPVLPPQPTLPPQPVLPPQPTRPPQPVLPPQPMLPPQPVLPPQPALPVRPEPLQPHLP 1010

Query: 280  EDTTAVTTTAPAAAVP-PAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNM 338
            E      T      +  PAP A   AA  P    P PP A    P   +  PA  +   +
Sbjct: 1011 EQAAPAATPGSQILLGHPAPYAVDVAAQVPTV--PVPPAAVLSPPLPEVLLPAAPEL--L 1066

Query: 339  DQFQPRMM----GIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPF 394
             QF   +      +Q  P      LPP          P P  P +A P  P      +P 
Sbjct: 1067 PQFPSSLATVSASVQSVPTQTATLLPPANP-------PLPGGPGIASPC-PTVQLTVEPV 1118

Query: 395  QASFQAQNEPLTQKPHQQEMEVEQPCIQEVKRHMSDNRKSRSRSASRSPKRRRSRSGSRS 454
            Q    +Q++P           + Q C        SD    +  S S        R   R+
Sbjct: 1119 QEEQASQDKP---------PGLPQSC---ESYGGSDVTSGKELSDSCEGAFGGGRLEGRA 1166

Query: 455  RRSRHRRS-RSRSRDRRRHSPR 475
             R  HRRS R+RSR  R   PR
Sbjct: 1167 ARKHHRRSTRARSRQERASRPR 1188



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 71/283 (25%), Positives = 99/283 (34%), Gaps = 45/283 (15%)

Query: 143  PVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQ 202
            PVAE+         PP+ +SS PP +A+ +S P   QL S +  + +A        QQL 
Sbjct: 1317 PVAEHPAPEAPESSPPLPLSSLPP-EASQDSAPYKDQLSSKEQPSFLAS-------QQLL 1368

Query: 203  QILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLL 262
                    P  P +P   ++              T T P         P   TA      
Sbjct: 1369 SQAGPSNPPGAPPAPLAPSSPPVTALPQDGAAPATSTMPE--------PASGTA------ 1414

Query: 263  DRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAAS---------P 313
             +      P+ +    +       T     AV P      P   AP AAS         P
Sbjct: 1415 SQAGGPGTPQGLTSELETSQPLAETHEAPLAVQPLVVGLAPCTPAPEAASTRDASAPREP 1474

Query: 314  PPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPT 373
             PP AP   P  G  QPA  Q   +    P  +G        Q+P PP G        PT
Sbjct: 1475 LPPPAPEPSPHSGTPQPALGQPAPL---LPAAVG-AVSLATSQLPSPPLG--------PT 1522

Query: 374  -PPFPPMAQPVIPPTPPVQQPF-QASFQAQNEPLTQKPHQQEM 414
             PP PP A       PP +  F  ++ ++ +E L    +Q+ +
Sbjct: 1523 VPPQPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTLLYQEHV 1565



 Score = 43.9 bits (102), Expect = 9e-04
 Identities = 70/283 (24%), Positives = 87/283 (30%), Gaps = 54/283 (19%)

Query: 133 DMAAGTSNAAPVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQL 192
           D A G      V        G P PP     E      P      P LP+S    A    
Sbjct: 562 DKARGPPVPLQVQVTYHAQAGQPGPPEPEEPEADQHLLP------PTLPTSATSLASDST 615

Query: 193 FQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPE 252
           F + QG  +    Q+ QQ           +VM    A  A        PS  +    PP 
Sbjct: 616 FDSGQGSTVYSDSQSSQQ-----------SVMLGSLADAA--------PSPAQCVCSPPV 656

Query: 253 QKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAAS 312
            +     + L       +P A              + PA A PP+     P  A   A  
Sbjct: 657 SEGPVLPQSLPSLGAYQQPTAAPGLP-------VGSVPAPACPPSLQQHFPDPAMSFAPV 709

Query: 313 PPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLP 372
            PPP  P    G G               QP   G Q  P+    PLP    +    ++P
Sbjct: 710 LPPPSTPMP-TGPG---------------QPAPPGQQPPPLAQPTPLPQ--VLAPQPVVP 751

Query: 373 TPPFPPMAQPVIPPTPPVQQPFQAS----FQAQNEPLTQKPHQ 411
             P PP   P + P   V  P Q       QA  +PL Q P Q
Sbjct: 752 LQPVPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQVPPQ 794



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 62/245 (25%), Positives = 84/245 (34%), Gaps = 38/245 (15%)

Query: 206 QTFQQPPKPQSPALDNAVMAQVQAITAQL-KTTPTQPSEQKAAFPPPEQKTAFDKKLLDR 264
           Q    P K + P +   V     A   Q     P +P   +   PP    +A        
Sbjct: 556 QDVGSPDKARGPPVPLQVQVTYHAQAGQPGPPEPEEPEADQHLLPPTLPTSATSLASDST 615

Query: 265 FD-------YDDEPEAVEESKKEDTTAVTTTAPAAAV--PPAPTATVPAAAAPAAASPPP 315
           FD       Y D  ++ ++S    + A    +PA  V  PP     V   + P+  +   
Sbjct: 616 FDSGQGSTVYSDS-QSSQQSVMLGSLADAAPSPAQCVCSPPVSEGPVLPQSLPSLGAYQQ 674

Query: 316 PQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPL--PPNGQMPGFGLLPT 373
           P A  G P   +  PA     ++ Q  P       DP     P+  PP+  MP     P 
Sbjct: 675 PTAAPGLPVGSVPAPACPP--SLQQHFP-------DPAMSFAPVLPPPSTPMPTGPGQPA 725

Query: 374 PPF---PPMAQP-----------VIP--PTPPVQQPFQASFQAQNEPLTQKPHQQEMEVE 417
           PP    PP+AQP           V+P  P PP   P+ A       P   KP Q      
Sbjct: 726 PPGQQPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQMPQAPL 785

Query: 418 QPCIQ 422
           QP  Q
Sbjct: 786 QPLAQ 790



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 33/105 (31%), Positives = 37/105 (35%), Gaps = 24/105 (22%)

Query: 634  PKKPENEVAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVG 693
            P  P  E A    A      P  P+P P P P P    P P    P  + P   G   + 
Sbjct: 1455 PCTPAPEAASTRDASA----PREPLPPPAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLA 1510

Query: 694  ALQPPAFTPPLGIPPPGFGPGVPPPPP---------PPPFLRPGF 729
              Q         +P P  GP VPP PP         PPP  R GF
Sbjct: 1511 TSQ---------LPSPPLGPTVPPQPPSALESDGEGPPP--RVGF 1544



 Score = 37.7 bits (86), Expect = 0.062
 Identities = 62/273 (22%), Positives = 79/273 (28%), Gaps = 67/273 (24%)

Query: 125  IEIIQPLLDMAAGTSNAAPVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQLPSSD 184
            I ++ P+  +A G     P   ++      P PP +  S  P    P+    +P  P+S 
Sbjct: 798  IPVVPPITPLA-GIDGLPPALPDLPTATVPPVPPPQYFS--PAVILPSLAAPLP--PASP 852

Query: 185  AFAAVAQLFQTTQGQQLQQILQTFQQPPKPQSPALDNA----VMAQVQAITAQLKTTPTQ 240
            A    A       G  L    +T         P L  A        + +  AQL   P  
Sbjct: 853  ALPLQAVKLPHPPGAPLAMPCRTIVPNAPATIPLLAVAPPGVAALSIHSAVAQLPGQPVY 912

Query: 241  PSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTA 300
            P    AAFP                     P  V  S       +  T P  A+PP PT 
Sbjct: 913  P----AAFPQMA------------------PTDVPPSPHHTVQNMRATPPQPALPPQPTL 950

Query: 301  TVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLP 360
                   P    PP P  P                              Q     Q  LP
Sbjct: 951  PPQPVLPPQPTLPPQPVLP-----------------------------PQPTRPPQPVLP 981

Query: 361  PNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQP 393
            P   +P     P P  PP  QP +P  P   QP
Sbjct: 982  PQPMLP-----PQPVLPP--QPALPVRPEPLQP 1007



 Score = 35.8 bits (81), Expect = 0.23
 Identities = 37/144 (25%), Positives = 48/144 (33%), Gaps = 26/144 (18%)

Query: 621  LDSDTLNPDWKGIPKKPENEVAQNGGAET-----SHTEPVSPIPKP--LPVPVPPIPVPA 673
            L  D   P    +P+      +Q GG  T     S  E   P+ +    P+ V P+ V  
Sbjct: 1394 LPQDGAAPATSTMPEPASGTASQAGGPGTPQGLTSELETSQPLAETHEAPLAVQPLVVGL 1453

Query: 674  PITVPPPQVP-------PHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLR 726
                P P+         P +P PP       P  +P  G P P  G        P P L 
Sbjct: 1454 APCTPAPEAASTRDASAPREPLPPPA-----PEPSPHSGTPQPALGQ-------PAPLLP 1501

Query: 727  PGFNPMHLPPGFLPPGPPPPITPP 750
                 + L    LP  P  P  PP
Sbjct: 1502 AAVGAVSLATSQLPSPPLGPTVPP 1525



 Score = 32.0 bits (71), Expect = 3.4
 Identities = 28/127 (22%), Positives = 47/127 (37%), Gaps = 19/127 (14%)

Query: 832 PGLIPLQRPPGMPPPHLQRFPLM---------------PPRPMPPHMMHRGPPPGPGGFA 876
           PGL   + P   PP  LQR  L+               P  P P  ++ +   PG    A
Sbjct: 55  PGLEAAEAPGPQPPQPLQRRVLLLCKTRRLIAERARGRPAAPAPAALVAQPGAPGAPADA 114

Query: 877 MPPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQ 936
            P P G + P    GP      +     P  GP        R++     + +P+P   ++
Sbjct: 115 GPEPVGTQEP----GPDPIAAAVETAPAPDGGPREEAAATVRKEDEGAAEAKPEPGRTRR 170

Query: 937 PQQQQQQ 943
            + ++++
Sbjct: 171 DEPEEEE 177


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.133    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 67,253,963
Number of Sequences: 37866
Number of extensions: 5548137
Number of successful extensions: 135710
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1338
Number of HSP's successfully gapped in prelim test: 2266
Number of HSP's that attempted gapping in prelim test: 29605
Number of HSP's gapped (non-prelim): 46882
length of query: 1125
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1012
effective length of database: 13,968,660
effective search space: 14136283920
effective search space used: 14136283920
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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