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Search of human proteins with 223941885
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223941885 protein tyrosine phosphatase, non-receptor type 3
isoform 4 [Homo sapiens]
(737 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223941885 protein tyrosine phosphatase, non-receptor type 3 i... 1507 0.0
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 1507 0.0
gi|223941882 protein tyrosine phosphatase, non-receptor type 3 i... 1485 0.0
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 1485 0.0
gi|223941891 protein tyrosine phosphatase, non-receptor type 3 i... 1188 0.0
gi|223941888 protein tyrosine phosphatase, non-receptor type 3 i... 1166 0.0
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 749 0.0
gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [... 214 2e-55
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ... 194 2e-49
gi|4506291 protein tyrosine phosphatase, non-receptor type 2 iso... 191 3e-48
gi|18104982 protein tyrosine phosphatase, non-receptor type 2 [H... 191 3e-48
gi|18104980 protein tyrosine phosphatase, non-receptor type 2 is... 191 3e-48
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 190 5e-48
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 190 5e-48
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 190 5e-48
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 190 5e-48
gi|109138573 protein tyrosine phosphatase, non-receptor type 20A... 185 1e-46
gi|109138561 protein tyrosine phosphatase, non-receptor type 20A... 185 1e-46
gi|109138557 protein tyrosine phosphatase, non-receptor type 20A... 185 1e-46
gi|108802617 protein tyrosine phosphatase, non-receptor type 20 ... 185 1e-46
gi|108802607 protein tyrosine phosphatase, non-receptor type 20 ... 185 1e-46
gi|108802604 protein tyrosine phosphatase, non-receptor type 20 ... 185 1e-46
gi|148728162 protein tyrosine phosphatase, receptor type, J isof... 182 1e-45
gi|4506289 protein tyrosine phosphatase, non-receptor type 1 [Ho... 180 4e-45
gi|241896926 protein tyrosine phosphatase, receptor type, H isof... 179 6e-45
gi|241896924 protein tyrosine phosphatase, receptor type, H isof... 179 6e-45
gi|157952215 protein tyrosine phosphatase, receptor type, B isof... 177 4e-44
gi|157952213 protein tyrosine phosphatase, receptor type, B isof... 177 4e-44
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 173 5e-43
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 173 5e-43
>gi|223941885 protein tyrosine phosphatase, non-receptor type 3
isoform 4 [Homo sapiens]
Length = 737
Score = 1507 bits (3901), Expect = 0.0
Identities = 737/737 (100%), Positives = 737/737 (100%)
Query: 1 MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL 60
MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL
Sbjct: 1 MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL 60
Query: 61 HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS 120
HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS
Sbjct: 61 HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS 120
Query: 121 FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK 180
FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK
Sbjct: 121 FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK 180
Query: 181 KLLPQEKNVLSQYWTMGSRNTKKRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTY 240
KLLPQEKNVLSQYWTMGSRNTKKRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTY
Sbjct: 181 KLLPQEKNVLSQYWTMGSRNTKKRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTY 240
Query: 241 KGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQ 300
KGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQ
Sbjct: 241 KGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQ 300
Query: 301 LLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLV 360
LLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLV
Sbjct: 301 LLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLV 360
Query: 361 VSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRR 420
VSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRR
Sbjct: 361 VSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRR 420
Query: 421 RAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRK 480
RAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRK
Sbjct: 421 RAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRK 480
Query: 481 KPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIA 540
KPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIA
Sbjct: 481 KPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIA 540
Query: 541 TQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQS 600
TQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQS
Sbjct: 541 TQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQS 600
Query: 601 EDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSE 660
EDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSE
Sbjct: 601 EDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSE 660
Query: 661 PVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCE 720
PVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCE
Sbjct: 661 PVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCE 720
Query: 721 AILRVYEEGLVQMLDPS 737
AILRVYEEGLVQMLDPS
Sbjct: 721 AILRVYEEGLVQMLDPS 737
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 1507 bits (3901), Expect = 0.0
Identities = 737/737 (100%), Positives = 737/737 (100%)
Query: 1 MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL 60
MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL
Sbjct: 132 MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL 191
Query: 61 HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS 120
HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS
Sbjct: 192 HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS 251
Query: 121 FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK 180
FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK
Sbjct: 252 FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK 311
Query: 181 KLLPQEKNVLSQYWTMGSRNTKKRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTY 240
KLLPQEKNVLSQYWTMGSRNTKKRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTY
Sbjct: 312 KLLPQEKNVLSQYWTMGSRNTKKRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTY 371
Query: 241 KGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQ 300
KGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQ
Sbjct: 372 KGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQ 431
Query: 301 LLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLV 360
LLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLV
Sbjct: 432 LLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLV 491
Query: 361 VSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRR 420
VSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRR
Sbjct: 492 VSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRR 551
Query: 421 RAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRK 480
RAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRK
Sbjct: 552 RAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRK 611
Query: 481 KPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIA 540
KPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIA
Sbjct: 612 KPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIA 671
Query: 541 TQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQS 600
TQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQS
Sbjct: 672 TQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQS 731
Query: 601 EDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSE 660
EDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSE
Sbjct: 732 EDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSE 791
Query: 661 PVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCE 720
PVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCE
Sbjct: 792 PVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCE 851
Query: 721 AILRVYEEGLVQMLDPS 737
AILRVYEEGLVQMLDPS
Sbjct: 852 AILRVYEEGLVQMLDPS 868
>gi|223941882 protein tyrosine phosphatase, non-receptor type 3
isoform 3 [Homo sapiens]
Length = 782
Score = 1485 bits (3845), Expect = 0.0
Identities = 737/782 (94%), Positives = 737/782 (94%), Gaps = 45/782 (5%)
Query: 1 MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL 60
MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL
Sbjct: 1 MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL 60
Query: 61 HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS 120
HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS
Sbjct: 61 HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS 120
Query: 121 FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK 180
FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK
Sbjct: 121 FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK 180
Query: 181 KLLPQEKNVLSQYWTMGSRNTKK------------------------------------- 203
KLLPQEKNVLSQYWTMGSRNTKK
Sbjct: 181 KLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSR 240
Query: 204 --------RSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQ 255
RSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQ
Sbjct: 241 SPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQ 300
Query: 256 NRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTE 315
NRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTE
Sbjct: 301 NRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTE 360
Query: 316 DASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIP 375
DASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIP
Sbjct: 361 DASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIP 420
Query: 376 KLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDEL 435
KLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDEL
Sbjct: 421 KLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDEL 480
Query: 436 NQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNL 495
NQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNL
Sbjct: 481 NQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNL 540
Query: 496 DKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQV 555
DKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQV
Sbjct: 541 DKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQV 600
Query: 556 VWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVT 615
VWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVT
Sbjct: 601 VWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVT 660
Query: 616 NTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGV 675
NTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGV
Sbjct: 661 NTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGV 720
Query: 676 LVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLD 735
LVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLD
Sbjct: 721 LVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLD 780
Query: 736 PS 737
PS
Sbjct: 781 PS 782
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 1485 bits (3845), Expect = 0.0
Identities = 737/782 (94%), Positives = 737/782 (94%), Gaps = 45/782 (5%)
Query: 1 MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL 60
MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL
Sbjct: 132 MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL 191
Query: 61 HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS 120
HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS
Sbjct: 192 HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS 251
Query: 121 FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK 180
FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK
Sbjct: 252 FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK 311
Query: 181 KLLPQEKNVLSQYWTMGSRNTKK------------------------------------- 203
KLLPQEKNVLSQYWTMGSRNTKK
Sbjct: 312 KLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSR 371
Query: 204 --------RSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQ 255
RSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQ
Sbjct: 372 SPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQ 431
Query: 256 NRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTE 315
NRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTE
Sbjct: 432 NRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTE 491
Query: 316 DASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIP 375
DASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIP
Sbjct: 492 DASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIP 551
Query: 376 KLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDEL 435
KLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDEL
Sbjct: 552 KLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDEL 611
Query: 436 NQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNL 495
NQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNL
Sbjct: 612 NQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNL 671
Query: 496 DKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQV 555
DKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQV
Sbjct: 672 DKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQV 731
Query: 556 VWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVT 615
VWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVT
Sbjct: 732 VWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVT 791
Query: 616 NTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGV 675
NTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGV
Sbjct: 792 NTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGV 851
Query: 676 LVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLD 735
LVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLD
Sbjct: 852 LVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLD 911
Query: 736 PS 737
PS
Sbjct: 912 PS 913
>gi|223941891 protein tyrosine phosphatase, non-receptor type 3
isoform 6 [Homo sapiens]
Length = 581
Score = 1188 bits (3073), Expect = 0.0
Identities = 581/581 (100%), Positives = 581/581 (100%)
Query: 157 MLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKRSPRLRHEIRKPR 216
MLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKRSPRLRHEIRKPR
Sbjct: 1 MLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKRSPRLRHEIRKPR 60
Query: 217 HSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQ 276
HSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQ
Sbjct: 61 HSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQ 120
Query: 277 KSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIR 336
KSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIR
Sbjct: 121 KSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIR 180
Query: 337 ITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTH 396
ITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTH
Sbjct: 181 ITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTH 240
Query: 397 DQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEG 456
DQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEG
Sbjct: 241 DQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEG 300
Query: 457 SMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGN 516
SMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGN
Sbjct: 301 SMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGN 360
Query: 517 EDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRT 576
EDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRT
Sbjct: 361 EDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRT 420
Query: 577 KCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDH 636
KCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDH
Sbjct: 421 KCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDH 480
Query: 637 GVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLD 696
GVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLD
Sbjct: 481 GVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLD 540
Query: 697 IVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLDPS 737
IVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLDPS
Sbjct: 541 IVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLDPS 581
>gi|223941888 protein tyrosine phosphatase, non-receptor type 3
isoform 5 [Homo sapiens]
Length = 626
Score = 1166 bits (3017), Expect = 0.0
Identities = 581/626 (92%), Positives = 581/626 (92%), Gaps = 45/626 (7%)
Query: 157 MLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKK------------- 203
MLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKK
Sbjct: 1 MLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGG 60
Query: 204 --------------------------------RSPRLRHEIRKPRHSSADNLANEMTYIT 231
RSPRLRHEIRKPRHSSADNLANEMTYIT
Sbjct: 61 MVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYIT 120
Query: 232 ETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGS 291
ETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGS
Sbjct: 121 ETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGS 180
Query: 292 CSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKG 351
CSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKG
Sbjct: 181 CSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKG 240
Query: 352 GVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHS 411
GVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHS
Sbjct: 241 GVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHS 300
Query: 412 RELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVL 471
RELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVL
Sbjct: 301 RELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVL 360
Query: 472 IQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPA 531
IQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPA
Sbjct: 361 IQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPA 420
Query: 532 ANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNH 591
ANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNH
Sbjct: 421 ANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNH 480
Query: 592 GGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNY 651
GGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNY
Sbjct: 481 GGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNY 540
Query: 652 VRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQT 711
VRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQT
Sbjct: 541 VRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQT 600
Query: 712 SSQYKFVCEAILRVYEEGLVQMLDPS 737
SSQYKFVCEAILRVYEEGLVQMLDPS
Sbjct: 601 SSQYKFVCEAILRVYEEGLVQMLDPS 626
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 749 bits (1935), Expect = 0.0
Identities = 387/791 (48%), Positives = 523/791 (66%), Gaps = 55/791 (6%)
Query: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 61
DI GRL CP N+A +LAS+AVQS GDY+ S + GYLSD FIP+Q +DF ++ LH
Sbjct: 133 DILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLH 192
Query: 62 EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 121
+QH GL +EAE Y+N ARTL+ YGVE H RD N ++MIG+ S G+ +Y+ + +
Sbjct: 193 QQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNT 252
Query: 122 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 181
+PW+ I+KISFK K+FFI R++ ESRE ++ FNM+NYR+CKNLWK+CVEHHTFF+ +
Sbjct: 253 FPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDR 312
Query: 182 LLPQEKNVLSQYWTMGSRNT-------------KKRSPRLRHEIRKP------------- 215
LP +KN + Y+T+GS+ K+++ + R R P
Sbjct: 313 PLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKLMDWEV 372
Query: 216 --RHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSY 273
R+S +D+ + + + ++ S Q+ + + + +P++ +
Sbjct: 373 VSRNSISDDRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHLVDHMVHTSPSEVF 432
Query: 274 LTQKSSSSV---------SPSSNAPGSCSPDGVD--QQLLDDFHRVTKGGSTEDASQYYC 322
+ Q+S SS SPS PG P + Q + ++++ S +D +
Sbjct: 433 VNQRSPSSTQANSIVLESSPSQETPGDGKPPALPPKQSKKNSWNQIHYSHSQQDLESHIN 492
Query: 323 DKND----------NGD---SYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESP 369
+ D NG LVLIR+ PDE+G+FGFN+KGG DQKMP++VSR+ P +P
Sbjct: 493 ETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTP 552
Query: 370 ADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADF 429
AD C+P+LNEGDQ+VLINGRDI+EHTHDQVV+FIKAS E HS EL L++R AV +
Sbjct: 553 ADLCVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCERHSGELMLLVRPNAVYDVVEE 612
Query: 430 KSEDELN-QLFPE-AIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAIT 487
K E+E + Q PE A + +L SM QL +GL +GTVL QF+QLYRKKPG+ ++
Sbjct: 613 KLENEPDFQYIPEKAPLDSVHQDDHSLRESMIQLAEGLITGTVLTQFDQLYRKKPGMTMS 672
Query: 488 FAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPH 547
AKLPQN+ KNRY+D+ PYD TRV+L+GNEDYINA+Y+NMEIP+++++N+YIA QGPLPH
Sbjct: 673 CAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINMEIPSSSIINQYIACQGPLPH 732
Query: 548 TCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAY 607
TC FWQ+ W+Q S++VMLTT ERGR KCHQYWP+P ++G + + C SE+ AY
Sbjct: 733 TCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAY 792
Query: 608 VSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV-DSEPVLVHC 666
+ R+M + N + E +T +QY+AWPDHGVPDDSSDFL+FV +VR+ R EPV+VHC
Sbjct: 793 IFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHC 852
Query: 667 SAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY 726
SAGIGRTGVL+TMETAMCL E N P+YPLDIVR MRDQRAMM+QT SQY+FVCEAIL+VY
Sbjct: 853 SAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVY 912
Query: 727 EEGLVQMLDPS 737
EEG V+ L S
Sbjct: 913 EEGFVKPLTTS 923
>gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [Homo
sapiens]
Length = 1187
Score = 214 bits (546), Expect = 2e-55
Identities = 110/282 (39%), Positives = 168/282 (59%), Gaps = 20/282 (7%)
Query: 461 LKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----QGN 516
LKK LE G V ++EQ+ +KK + A LP+N +++R ++V+PY+ RV L + N
Sbjct: 900 LKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENN 959
Query: 517 EDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRT 576
YINAS++ + + A YIATQGPLPHTC FWQ+VW+Q +++I M+T E GRT
Sbjct: 960 TGYINASHIKVVVGGAEW--HYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017
Query: 577 KCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAW 633
K H+YWP +G F + + ++ Y + + V + +G+E TV HLQY W
Sbjct: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077
Query: 634 PDHGVPDDSSDFLEFVNYVRSLRVDSE-----------PVLVHCSAGIGRTGVLVTMETA 682
PDHG P+D FL ++ ++S+R + P++VHCSAG+GRTGVL+ E
Sbjct: 1078 PDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELM 1137
Query: 683 MCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 724
+ E N + ++R +R+QR M+QT +QYKFV + +++
Sbjct: 1138 IYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179
Score = 78.2 bits (191), Expect = 3e-14
Identities = 70/303 (23%), Positives = 130/303 (42%), Gaps = 22/303 (7%)
Query: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQN-------EDFL 54
D+ EGRL C L+ + LA AVQ+ FGDYN +L + P E+
Sbjct: 125 DVLEGRLRCTLDQVIRLAGLAVQADFGDYNQ-FDSQDFLREYVLFPMDLALEEAVLEELT 183
Query: 55 TKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYR 114
KV H+ HSG+ +EAE YIN LD +G E+ +D H + +GI G+ V
Sbjct: 184 QKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFVRN 243
Query: 115 KYICTS-FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEH 173
+ + Y W ++ I+ + + + ++E F+ + + K + +
Sbjct: 244 RIGRQAVIYRWNDMGNITHNKSTILV-----ELINKEETALFHTDDIENAKYISRLFATR 298
Query: 174 HTFFQAKKLLPQEKN---VLSQYWTMGSRNTKKRSPRLRH--EIRKPRHSSADNLANEMT 228
H F++ K+ ++ N + + T + ++ P + ++ H S + + +
Sbjct: 299 HKFYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQPYILPPVHVQCGEHYSETHTSQDSI 358
Query: 229 YITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNA 288
+ E ++ SL + V+ S++ N +QS++ +S VS + +
Sbjct: 359 FHGNEEALYCNSHNSLDLNYLNGTVTNGSVCSVHSVNSLNCSQSFI---QASPVSSNLSI 415
Query: 289 PGS 291
PGS
Sbjct: 416 PGS 418
>gi|150418005 protein tyrosine phosphatase, non-receptor type 21 [Homo
sapiens]
Length = 1174
Score = 194 bits (494), Expect = 2e-49
Identities = 106/283 (37%), Positives = 166/283 (58%), Gaps = 22/283 (7%)
Query: 461 LKKGLESGTVLIQFEQLYRKK--PGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----Q 514
L++ LE G V ++E++ +K+ G T A+LP+N ++NR++DVLPYD RV L +
Sbjct: 887 LEQRLEQGMVFTEYERILKKRLVDGECST-ARLPENAERNRFQDVLPYDDVRVELVPTKE 945
Query: 515 GNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERG 574
N YINAS++ + + + + YIATQGPL +TC FWQ+VW+Q +++I M+T E G
Sbjct: 946 NNTGYINASHIKVSV--SGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGG 1003
Query: 575 RTKCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYV 631
R K +YWP + + +G F I + + Y + + + + TG+E TV HLQY
Sbjct: 1004 REKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYT 1063
Query: 632 AWPDHGVPDDSSDFLEFVNYVRSLR----------VDSEPVLVHCSAGIGRTGVLVTMET 681
WP+HG P+D FL ++ ++S+R + P+LVHCSAG+GRTGV++ E
Sbjct: 1064 DWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEI 1123
Query: 682 AMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 724
+ E N + ++ +R QR M+VQT QY FV +++
Sbjct: 1124 MIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ 1166
Score = 82.0 bits (201), Expect = 2e-15
Identities = 81/321 (25%), Positives = 135/321 (42%), Gaps = 44/321 (13%)
Query: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNS----------SIHHPGYLSDSHFIPDQNE 51
DI EG + C L A+ LA AVQ+ FGD++ ++ G+L D + E
Sbjct: 127 DILEGSIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKVL----E 182
Query: 52 DFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVA 111
+ KV LH+++ GL +AE Y+ +D YG E + +D D+ IG G+
Sbjct: 183 EATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIF 242
Query: 112 V-YRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSC 170
V ++ + W +I +S + F + + ++E + F + + K +W+ C
Sbjct: 243 VKHKNGRHPVVFRWHDIANMSHNKSFFAL-----ELANKEETIQFQTEDMETAKYIWRLC 297
Query: 171 VEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKRS------------PRLRH--EIRKPR 216
V H F++ + Q + V + R++ + S P+L + +P
Sbjct: 298 VARHKFYRLNQCNLQTQTVTVN--PIRRRSSSRMSLPKPQPYVMPPPPQLHYNGHYTEPY 355
Query: 217 HSSADNL--ANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYL 274
SS DNL N+ Y ++ + L + + V S + S NNP Q YL
Sbjct: 356 ASSQDNLFVPNQNGYYCHSQTSLDRAQIDLNGRIRNGSVYSAHSTN----SLNNP-QPYL 410
Query: 275 TQKSSSSVSPSSNAPGSCSPD 295
Q S S +PS PD
Sbjct: 411 -QPSPMSSNPSITGSDVMRPD 430
>gi|4506291 protein tyrosine phosphatase, non-receptor type 2
isoform 1 [Homo sapiens]
Length = 415
Score = 191 bits (484), Expect = 3e-48
Identities = 101/241 (41%), Positives = 137/241 (56%), Gaps = 10/241 (4%)
Query: 489 AKLPQNLDKNRYKDVLPYDTTRVLLQGNE-DYINASYVNMEIPAANLVNKYIATQGPLPH 547
AK P+N ++NRY+DV PYD +RV LQ E DYINAS V++E YI TQGPLP+
Sbjct: 37 AKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIE----EAQRSYILTQGPLPN 92
Query: 548 TCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP--DPPDVMNHGGFHIQCQSEDCTI 605
TC FW +VW QK +VML + E+ KC QYWP D + GF ++ SED
Sbjct: 93 TCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKS 152
Query: 606 AYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVR---SLRVDSEPV 662
Y + + N +GE T++H Y WPD GVP+ + FL F+ VR SL D P
Sbjct: 153 YYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPA 212
Query: 663 LVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAI 722
++HCSAGIGR+G ++T + L E+ I ++ MR R ++QT Q +F AI
Sbjct: 213 VIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAI 272
Query: 723 L 723
+
Sbjct: 273 I 273
>gi|18104982 protein tyrosine phosphatase, non-receptor type 2 [Homo
sapiens]
Length = 353
Score = 191 bits (484), Expect = 3e-48
Identities = 101/241 (41%), Positives = 137/241 (56%), Gaps = 10/241 (4%)
Query: 489 AKLPQNLDKNRYKDVLPYDTTRVLLQGNE-DYINASYVNMEIPAANLVNKYIATQGPLPH 547
AK P+N ++NRY+DV PYD +RV LQ E DYINAS V++E YI TQGPLP+
Sbjct: 37 AKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIE----EAQRSYILTQGPLPN 92
Query: 548 TCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP--DPPDVMNHGGFHIQCQSEDCTI 605
TC FW +VW QK +VML + E+ KC QYWP D + GF ++ SED
Sbjct: 93 TCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKS 152
Query: 606 AYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVR---SLRVDSEPV 662
Y + + N +GE T++H Y WPD GVP+ + FL F+ VR SL D P
Sbjct: 153 YYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPA 212
Query: 663 LVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAI 722
++HCSAGIGR+G ++T + L E+ I ++ MR R ++QT Q +F AI
Sbjct: 213 VIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAI 272
Query: 723 L 723
+
Sbjct: 273 I 273
>gi|18104980 protein tyrosine phosphatase, non-receptor type 2
isoform 2 [Homo sapiens]
Length = 387
Score = 191 bits (484), Expect = 3e-48
Identities = 101/241 (41%), Positives = 137/241 (56%), Gaps = 10/241 (4%)
Query: 489 AKLPQNLDKNRYKDVLPYDTTRVLLQGNE-DYINASYVNMEIPAANLVNKYIATQGPLPH 547
AK P+N ++NRY+DV PYD +RV LQ E DYINAS V++E YI TQGPLP+
Sbjct: 37 AKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIE----EAQRSYILTQGPLPN 92
Query: 548 TCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP--DPPDVMNHGGFHIQCQSEDCTI 605
TC FW +VW QK +VML + E+ KC QYWP D + GF ++ SED
Sbjct: 93 TCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKS 152
Query: 606 AYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVR---SLRVDSEPV 662
Y + + N +GE T++H Y WPD GVP+ + FL F+ VR SL D P
Sbjct: 153 YYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPA 212
Query: 663 LVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAI 722
++HCSAGIGR+G ++T + L E+ I ++ MR R ++QT Q +F AI
Sbjct: 213 VIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAI 272
Query: 723 L 723
+
Sbjct: 273 I 273
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 190 bits (482), Expect = 5e-48
Identities = 110/299 (36%), Positives = 156/299 (52%), Gaps = 5/299 (1%)
Query: 429 FKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITF 488
F + DEL L + P G L+ + L+ L+ G + E L KP
Sbjct: 2177 FLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLI 2236
Query: 489 AKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHT 548
+ +N KNRYK++LPYD TRV L YINAS++ + + V YIA QGPLP T
Sbjct: 2237 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFV--YIACQGPLPTT 2294
Query: 549 CAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD--PPDVMNHGGFHIQCQSEDCTIA 606
FWQ++W+QK ++I M+T E + KC +YWP+ M +
Sbjct: 2295 VGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKG 2354
Query: 607 YVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHC 666
+V R M + + QT E ++HL + AWPDH P D L F++Y+R + S P++ HC
Sbjct: 2355 FVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH-RSGPIITHC 2413
Query: 667 SAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 725
SAGIGR+G L+ ++ + L ++L D+VR MR QR MVQT QY F + IL V
Sbjct: 2414 SAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2472
Score = 76.3 bits (186), Expect = 1e-13
Identities = 99/492 (20%), Positives = 184/492 (37%), Gaps = 93/492 (18%)
Query: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFL------T 55
DI E R+ C ++++LAS A+Q+ +GDY +H Y H++P + + L
Sbjct: 686 DILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKE 745
Query: 56 KVESLHEQHSGLKQSEAESCYINIARTLDFYGVELH--SGRDLHNLDLMIGIASAGVAVY 113
++ LH + G + E E ++ + + L YGV H +++G+ S GV V+
Sbjct: 746 ELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVF 805
Query: 114 RKY----ICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKS 169
+ +PW KISF +KK + Q ++ +H F N + C+ L
Sbjct: 806 EVHNGVRTLVLRFPWRETKKISFSKKKITL---QNTSDGIKH--GFQTDNSKICQYLLHL 860
Query: 170 CVEHHTF-------------------------FQAKKLLPQEKNVLSQYWTMGSRNTKKR 204
C H F QA+ + ++ S K
Sbjct: 861 CSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTLNKL 920
Query: 205 SPR---LRHEIRK-----------PRHSSADNLANEMTYITETEDVFYTY----KGSLAP 246
+ R ++ EI K P +S+ ++ ++ + ++ +Y + SL P
Sbjct: 921 AVRPLSVQAEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYP 980
Query: 247 QDSDSEVSQNRSP-----------HQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPD 295
+ V+ P HQ S S+ +S SV+ + +P +
Sbjct: 981 HRKNVIVNMEPPPQTVAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHE 1040
Query: 296 GVDQQLLDDFHR----VTKGGSTEDASQYYCDKND----------NGDSYLVLIRITPDE 341
+ D +T S +SQ +ND + + + L+ + D
Sbjct: 1041 SDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDA 1100
Query: 342 DGKFGFNLKGGVDQ---KMPLVVSRINPESPADT--CIPKLNEGDQIVLINGRDISEHTH 396
GF + GG + + +S + P PAD C L GD+++ +N + +H
Sbjct: 1101 KYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGC---LKPGDRLISVNSVSLEGVSH 1157
Query: 397 DQVVMFIKASRE 408
+ ++ + E
Sbjct: 1158 HAAIEILQNAPE 1169
Score = 39.7 bits (91), Expect = 0.010
Identities = 56/256 (21%), Positives = 103/256 (40%), Gaps = 34/256 (13%)
Query: 186 EKNVLSQYWTMGSRNTKK-RSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSL 244
E++ S M ++ K+ +SP R S D+L +T ++ + S
Sbjct: 1630 EQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDL------VTAPANISNSTWSSA 1683
Query: 245 APQDSDSEVSQNRSPHQESLSENNP--AQSYLTQK---------SSSSVSPSSNAPGSC- 292
Q + VSQ +S H+ S+ + Y QK S+ S P APG
Sbjct: 1684 LHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSY 1743
Query: 293 --SPDGVDQQLLDDFH--RVTKGGSTEDASQYYCDKNDNGDSYLV----LIRITPDEDGK 344
+ +D +H +++ E+ + D ++ + + + LI + E G
Sbjct: 1744 QPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGS 1803
Query: 345 FGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIK 404
GF + G + V I + +D +L GD+++ +N D++ TH V ++
Sbjct: 1804 LGFTVTKGNQRIGCYVHDVIQDPAKSDG---RLKPGDRLIKVNDTDVTNMTHTDAVNLLR 1860
Query: 405 ASRESHSRELALVIRR 420
A+ S+ + LVI R
Sbjct: 1861 AA----SKTVRLVIGR 1872
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 190 bits (482), Expect = 5e-48
Identities = 110/299 (36%), Positives = 156/299 (52%), Gaps = 5/299 (1%)
Query: 429 FKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITF 488
F + DEL L + P G L+ + L+ L+ G + E L KP
Sbjct: 1981 FLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLI 2040
Query: 489 AKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHT 548
+ +N KNRYK++LPYD TRV L YINAS++ + + V YIA QGPLP T
Sbjct: 2041 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFV--YIACQGPLPTT 2098
Query: 549 CAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD--PPDVMNHGGFHIQCQSEDCTIA 606
FWQ++W+QK ++I M+T E + KC +YWP+ M +
Sbjct: 2099 VGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKG 2158
Query: 607 YVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHC 666
+V R M + + QT E ++HL + AWPDH P D L F++Y+R + S P++ HC
Sbjct: 2159 FVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH-RSGPIITHC 2217
Query: 667 SAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 725
SAGIGR+G L+ ++ + L ++L D+VR MR QR MVQT QY F + IL V
Sbjct: 2218 SAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2276
Score = 75.9 bits (185), Expect = 1e-13
Identities = 50/187 (26%), Positives = 85/187 (45%), Gaps = 17/187 (9%)
Query: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFL------T 55
DI E R+ C ++++LAS A+Q+ +GDY +H Y H++P + + L
Sbjct: 686 DILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKE 745
Query: 56 KVESLHEQHSGLKQSEAESCYINIARTLDFYGVELH--SGRDLHNLDLMIGIASAGVAVY 113
++ LH + G + E E ++ + + L YGV H +++G+ S GV V+
Sbjct: 746 ELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVF 805
Query: 114 RKY----ICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKS 169
+ +PW KISF +KK + Q ++ +H F N + C+ L
Sbjct: 806 EVHNGVRTLVLRFPWRETKKISFSKKKITL---QNTSDGIKH--GFQTDNSKICQYLLHL 860
Query: 170 CVEHHTF 176
C H F
Sbjct: 861 CSYQHKF 867
Score = 39.7 bits (91), Expect = 0.010
Identities = 56/256 (21%), Positives = 103/256 (40%), Gaps = 34/256 (13%)
Query: 186 EKNVLSQYWTMGSRNTKK-RSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSL 244
E++ S M ++ K+ +SP R S D+L +T ++ + S
Sbjct: 1434 EQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDL------VTAPANISNSTWSSA 1487
Query: 245 APQDSDSEVSQNRSPHQESLSENNP--AQSYLTQK---------SSSSVSPSSNAPGSC- 292
Q + VSQ +S H+ S+ + Y QK S+ S P APG
Sbjct: 1488 LHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSY 1547
Query: 293 --SPDGVDQQLLDDFH--RVTKGGSTEDASQYYCDKNDNGDSYLV----LIRITPDEDGK 344
+ +D +H +++ E+ + D ++ + + + LI + E G
Sbjct: 1548 QPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGS 1607
Query: 345 FGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIK 404
GF + G + V I + +D +L GD+++ +N D++ TH V ++
Sbjct: 1608 LGFTVTKGNQRIGCYVHDVIQDPAKSDG---RLKPGDRLIKVNDTDVTNMTHTDAVNLLR 1664
Query: 405 ASRESHSRELALVIRR 420
A+ S+ + LVI R
Sbjct: 1665 AA----SKTVRLVIGR 1676
Score = 31.2 bits (69), Expect = 3.6
Identities = 16/62 (25%), Positives = 34/62 (54%), Gaps = 4/62 (6%)
Query: 342 DGKFGFNLKGGVDQKMP---LVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQ 398
D G ++ GGV+ + + V + P+ A++ ++++GD+++ +NG + TH Q
Sbjct: 1184 DNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESD-GRIHKGDRVLAVNGVSLEGATHKQ 1242
Query: 399 VV 400
V
Sbjct: 1243 AV 1244
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 190 bits (482), Expect = 5e-48
Identities = 110/299 (36%), Positives = 156/299 (52%), Gaps = 5/299 (1%)
Query: 429 FKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITF 488
F + DEL L + P G L+ + L+ L+ G + E L KP
Sbjct: 2172 FLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLI 2231
Query: 489 AKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHT 548
+ +N KNRYK++LPYD TRV L YINAS++ + + V YIA QGPLP T
Sbjct: 2232 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFV--YIACQGPLPTT 2289
Query: 549 CAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD--PPDVMNHGGFHIQCQSEDCTIA 606
FWQ++W+QK ++I M+T E + KC +YWP+ M +
Sbjct: 2290 VGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKG 2349
Query: 607 YVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHC 666
+V R M + + QT E ++HL + AWPDH P D L F++Y+R + S P++ HC
Sbjct: 2350 FVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH-RSGPIITHC 2408
Query: 667 SAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 725
SAGIGR+G L+ ++ + L ++L D+VR MR QR MVQT QY F + IL V
Sbjct: 2409 SAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2467
Score = 76.3 bits (186), Expect = 1e-13
Identities = 99/492 (20%), Positives = 184/492 (37%), Gaps = 93/492 (18%)
Query: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFL------T 55
DI E R+ C ++++LAS A+Q+ +GDY +H Y H++P + + L
Sbjct: 686 DILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKE 745
Query: 56 KVESLHEQHSGLKQSEAESCYINIARTLDFYGVELH--SGRDLHNLDLMIGIASAGVAVY 113
++ LH + G + E E ++ + + L YGV H +++G+ S GV V+
Sbjct: 746 ELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVF 805
Query: 114 RKY----ICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKS 169
+ +PW KISF +KK + Q ++ +H F N + C+ L
Sbjct: 806 EVHNGVRTLVLRFPWRETKKISFSKKKITL---QNTSDGIKH--GFQTDNSKICQYLLHL 860
Query: 170 CVEHHTF-------------------------FQAKKLLPQEKNVLSQYWTMGSRNTKKR 204
C H F QA+ + ++ S K
Sbjct: 861 CSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTLNKL 920
Query: 205 SPR---LRHEIRK-----------PRHSSADNLANEMTYITETEDVFYTY----KGSLAP 246
+ R ++ EI K P +S+ ++ ++ + ++ +Y + SL P
Sbjct: 921 AVRPLSVQAEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYP 980
Query: 247 QDSDSEVSQNRSP-----------HQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPD 295
+ V+ P HQ S S+ +S SV+ + +P +
Sbjct: 981 HRKNVIVNMEPPPQTVAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHE 1040
Query: 296 GVDQQLLDDFHR----VTKGGSTEDASQYYCDKND----------NGDSYLVLIRITPDE 341
+ D +T S +SQ +ND + + + L+ + D
Sbjct: 1041 SDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDA 1100
Query: 342 DGKFGFNLKGGVDQ---KMPLVVSRINPESPADT--CIPKLNEGDQIVLINGRDISEHTH 396
GF + GG + + +S + P PAD C L GD+++ +N + +H
Sbjct: 1101 KYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGC---LKPGDRLISVNSVSLEGVSH 1157
Query: 397 DQVVMFIKASRE 408
+ ++ + E
Sbjct: 1158 HAAIEILQNAPE 1169
Score = 39.7 bits (91), Expect = 0.010
Identities = 56/256 (21%), Positives = 103/256 (40%), Gaps = 34/256 (13%)
Query: 186 EKNVLSQYWTMGSRNTKK-RSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSL 244
E++ S M ++ K+ +SP R S D+L +T ++ + S
Sbjct: 1625 EQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDL------VTAPANISNSTWSSA 1678
Query: 245 APQDSDSEVSQNRSPHQESLSENNP--AQSYLTQK---------SSSSVSPSSNAPGSC- 292
Q + VSQ +S H+ S+ + Y QK S+ S P APG
Sbjct: 1679 LHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSY 1738
Query: 293 --SPDGVDQQLLDDFH--RVTKGGSTEDASQYYCDKNDNGDSYLV----LIRITPDEDGK 344
+ +D +H +++ E+ + D ++ + + + LI + E G
Sbjct: 1739 QPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGS 1798
Query: 345 FGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIK 404
GF + G + V I + +D +L GD+++ +N D++ TH V ++
Sbjct: 1799 LGFTVTKGNQRIGCYVHDVIQDPAKSDG---RLKPGDRLIKVNDTDVTNMTHTDAVNLLR 1855
Query: 405 ASRESHSRELALVIRR 420
A+ S+ + LVI R
Sbjct: 1856 AA----SKTVRLVIGR 1867
Score = 31.2 bits (69), Expect = 3.6
Identities = 16/62 (25%), Positives = 34/62 (54%), Gaps = 4/62 (6%)
Query: 342 DGKFGFNLKGGVDQKMP---LVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQ 398
D G ++ GGV+ + + V + P+ A++ ++++GD+++ +NG + TH Q
Sbjct: 1375 DNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESD-GRIHKGDRVLAVNGVSLEGATHKQ 1433
Query: 399 VV 400
V
Sbjct: 1434 AV 1435
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 190 bits (482), Expect = 5e-48
Identities = 110/299 (36%), Positives = 156/299 (52%), Gaps = 5/299 (1%)
Query: 429 FKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITF 488
F + DEL L + P G L+ + L+ L+ G + E L KP
Sbjct: 2153 FLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLI 2212
Query: 489 AKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHT 548
+ +N KNRYK++LPYD TRV L YINAS++ + + V YIA QGPLP T
Sbjct: 2213 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFV--YIACQGPLPTT 2270
Query: 549 CAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD--PPDVMNHGGFHIQCQSEDCTIA 606
FWQ++W+QK ++I M+T E + KC +YWP+ M +
Sbjct: 2271 VGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKG 2330
Query: 607 YVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHC 666
+V R M + + QT E ++HL + AWPDH P D L F++Y+R + S P++ HC
Sbjct: 2331 FVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH-RSGPIITHC 2389
Query: 667 SAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 725
SAGIGR+G L+ ++ + L ++L D+VR MR QR MVQT QY F + IL V
Sbjct: 2390 SAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2448
Score = 75.9 bits (185), Expect = 1e-13
Identities = 50/187 (26%), Positives = 85/187 (45%), Gaps = 17/187 (9%)
Query: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFL------T 55
DI E R+ C ++++LAS A+Q+ +GDY +H Y H++P + + L
Sbjct: 686 DILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKE 745
Query: 56 KVESLHEQHSGLKQSEAESCYINIARTLDFYGVELH--SGRDLHNLDLMIGIASAGVAVY 113
++ LH + G + E E ++ + + L YGV H +++G+ S GV V+
Sbjct: 746 ELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVF 805
Query: 114 RKY----ICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKS 169
+ +PW KISF +KK + Q ++ +H F N + C+ L
Sbjct: 806 EVHNGVRTLVLRFPWRETKKISFSKKKITL---QNTSDGIKH--GFQTDNSKICQYLLHL 860
Query: 170 CVEHHTF 176
C H F
Sbjct: 861 CSYQHKF 867
Score = 39.7 bits (91), Expect = 0.010
Identities = 56/256 (21%), Positives = 103/256 (40%), Gaps = 34/256 (13%)
Query: 186 EKNVLSQYWTMGSRNTKK-RSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSL 244
E++ S M ++ K+ +SP R S D+L +T ++ + S
Sbjct: 1606 EQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDL------VTAPANISNSTWSSA 1659
Query: 245 APQDSDSEVSQNRSPHQESLSENNP--AQSYLTQK---------SSSSVSPSSNAPGSC- 292
Q + VSQ +S H+ S+ + Y QK S+ S P APG
Sbjct: 1660 LHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSY 1719
Query: 293 --SPDGVDQQLLDDFH--RVTKGGSTEDASQYYCDKNDNGDSYLV----LIRITPDEDGK 344
+ +D +H +++ E+ + D ++ + + + LI + E G
Sbjct: 1720 QPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGS 1779
Query: 345 FGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIK 404
GF + G + V I + +D +L GD+++ +N D++ TH V ++
Sbjct: 1780 LGFTVTKGNQRIGCYVHDVIQDPAKSDG---RLKPGDRLIKVNDTDVTNMTHTDAVNLLR 1836
Query: 405 ASRESHSRELALVIRR 420
A+ S+ + LVI R
Sbjct: 1837 AA----SKTVRLVIGR 1848
Score = 31.2 bits (69), Expect = 3.6
Identities = 16/62 (25%), Positives = 34/62 (54%), Gaps = 4/62 (6%)
Query: 342 DGKFGFNLKGGVDQKMP---LVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQ 398
D G ++ GGV+ + + V + P+ A++ ++++GD+++ +NG + TH Q
Sbjct: 1356 DNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESD-GRIHKGDRVLAVNGVSLEGATHKQ 1414
Query: 399 VV 400
V
Sbjct: 1415 AV 1416
>gi|109138573 protein tyrosine phosphatase, non-receptor type 20A
isoform 8 [Homo sapiens]
Length = 339
Score = 185 bits (470), Expect = 1e-46
Identities = 96/237 (40%), Positives = 136/237 (57%), Gaps = 8/237 (3%)
Query: 492 PQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQ 551
P N +KNRY+D+LPYD+TRV L ++DYINASY+ + YIATQGPL T
Sbjct: 100 PSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVNCGEEYF--YIATQGPLLSTIDD 157
Query: 552 FWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYV 608
FWQ+V + ++I M+T E G KC+ YWP P + H F + ++ ++
Sbjct: 158 FWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKH--FRVFLENYQILQYFI 215
Query: 609 SREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSA 668
R V TG H+V LQ+ WPDHG P + F++++ Y R + P++VHCSA
Sbjct: 216 IRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTG-PMVVHCSA 274
Query: 669 GIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 725
GIGRTGV + ++ C +N +DIV +MR+QR+ MVQT QY F + +L V
Sbjct: 275 GIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV 331
>gi|109138561 protein tyrosine phosphatase, non-receptor type 20A
isoform 3 [Homo sapiens]
Length = 411
Score = 185 bits (470), Expect = 1e-46
Identities = 96/237 (40%), Positives = 136/237 (57%), Gaps = 8/237 (3%)
Query: 492 PQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQ 551
P N +KNRY+D+LPYD+TRV L ++DYINASY+ + YIATQGPL T
Sbjct: 172 PSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVNCGEEYF--YIATQGPLLSTIDD 229
Query: 552 FWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYV 608
FWQ+V + ++I M+T E G KC+ YWP P + H F + ++ ++
Sbjct: 230 FWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKH--FRVFLENYQILQYFI 287
Query: 609 SREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSA 668
R V TG H+V LQ+ WPDHG P + F++++ Y R + P++VHCSA
Sbjct: 288 IRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTG-PMVVHCSA 346
Query: 669 GIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 725
GIGRTGV + ++ C +N +DIV +MR+QR+ MVQT QY F + +L V
Sbjct: 347 GIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV 403
>gi|109138557 protein tyrosine phosphatase, non-receptor type 20A
isoform 1 [Homo sapiens]
Length = 420
Score = 185 bits (470), Expect = 1e-46
Identities = 96/237 (40%), Positives = 136/237 (57%), Gaps = 8/237 (3%)
Query: 492 PQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQ 551
P N +KNRY+D+LPYD+TRV L ++DYINASY+ + YIATQGPL T
Sbjct: 181 PSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVNCGEEYF--YIATQGPLLSTIDD 238
Query: 552 FWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYV 608
FWQ+V + ++I M+T E G KC+ YWP P + H F + ++ ++
Sbjct: 239 FWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKH--FRVFLENYQILQYFI 296
Query: 609 SREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSA 668
R V TG H+V LQ+ WPDHG P + F++++ Y R + P++VHCSA
Sbjct: 297 IRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTG-PMVVHCSA 355
Query: 669 GIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 725
GIGRTGV + ++ C +N +DIV +MR+QR+ MVQT QY F + +L V
Sbjct: 356 GIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV 412
>gi|108802617 protein tyrosine phosphatase, non-receptor type 20
isoform 8 [Homo sapiens]
Length = 339
Score = 185 bits (470), Expect = 1e-46
Identities = 96/237 (40%), Positives = 136/237 (57%), Gaps = 8/237 (3%)
Query: 492 PQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQ 551
P N +KNRY+D+LPYD+TRV L ++DYINASY+ + YIATQGPL T
Sbjct: 100 PSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVNCGEEYF--YIATQGPLLSTIDD 157
Query: 552 FWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYV 608
FWQ+V + ++I M+T E G KC+ YWP P + H F + ++ ++
Sbjct: 158 FWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKH--FRVFLENYQILQYFI 215
Query: 609 SREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSA 668
R V TG H+V LQ+ WPDHG P + F++++ Y R + P++VHCSA
Sbjct: 216 IRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTG-PMVVHCSA 274
Query: 669 GIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 725
GIGRTGV + ++ C +N +DIV +MR+QR+ MVQT QY F + +L V
Sbjct: 275 GIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV 331
>gi|108802607 protein tyrosine phosphatase, non-receptor type 20
isoform 3 [Homo sapiens]
Length = 411
Score = 185 bits (470), Expect = 1e-46
Identities = 96/237 (40%), Positives = 136/237 (57%), Gaps = 8/237 (3%)
Query: 492 PQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQ 551
P N +KNRY+D+LPYD+TRV L ++DYINASY+ + YIATQGPL T
Sbjct: 172 PSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVNCGEEYF--YIATQGPLLSTIDD 229
Query: 552 FWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYV 608
FWQ+V + ++I M+T E G KC+ YWP P + H F + ++ ++
Sbjct: 230 FWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKH--FRVFLENYQILQYFI 287
Query: 609 SREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSA 668
R V TG H+V LQ+ WPDHG P + F++++ Y R + P++VHCSA
Sbjct: 288 IRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTG-PMVVHCSA 346
Query: 669 GIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 725
GIGRTGV + ++ C +N +DIV +MR+QR+ MVQT QY F + +L V
Sbjct: 347 GIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV 403
>gi|108802604 protein tyrosine phosphatase, non-receptor type 20
isoform 1 [Homo sapiens]
Length = 420
Score = 185 bits (470), Expect = 1e-46
Identities = 96/237 (40%), Positives = 136/237 (57%), Gaps = 8/237 (3%)
Query: 492 PQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQ 551
P N +KNRY+D+LPYD+TRV L ++DYINASY+ + YIATQGPL T
Sbjct: 181 PSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVNCGEEYF--YIATQGPLLSTIDD 238
Query: 552 FWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYV 608
FWQ+V + ++I M+T E G KC+ YWP P + H F + ++ ++
Sbjct: 239 FWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKH--FRVFLENYQILQYFI 296
Query: 609 SREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSA 668
R V TG H+V LQ+ WPDHG P + F++++ Y R + P++VHCSA
Sbjct: 297 IRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTG-PMVVHCSA 355
Query: 669 GIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 725
GIGRTGV + ++ C +N +DIV +MR+QR+ MVQT QY F + +L V
Sbjct: 356 GIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV 412
>gi|148728162 protein tyrosine phosphatase, receptor type, J isoform 1
precursor [Homo sapiens]
Length = 1337
Score = 182 bits (461), Expect = 1e-45
Identities = 95/244 (38%), Positives = 136/244 (55%), Gaps = 12/244 (4%)
Query: 489 AKLPQNLDKNRYKDVLPYDTTRVLLQ----GNEDYINASYVNMEIPAANLVNKYIATQGP 544
A+L +N KNRY +VLPYD +RV L +DYINA+Y+ P + +IATQGP
Sbjct: 1060 AELAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYM----PGYHSKKDFIATQGP 1115
Query: 545 LPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCT 604
LP+T FW++VW++ + I+MLT E+GRTKC +YWP ++G + SE
Sbjct: 1116 LPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPS-KQAQDYGDITVAMTSEIVL 1174
Query: 605 IAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDS---EP 661
+ R+ V N QT E H + + +WPDHGVPD + + F VR S P
Sbjct: 1175 PEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESP 1234
Query: 662 VLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEA 721
+LVHCSAG+GRTG + ++ + E + IV +R R +MVQT QY F+ +
Sbjct: 1235 ILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQC 1294
Query: 722 ILRV 725
+L +
Sbjct: 1295 VLDI 1298
>gi|4506289 protein tyrosine phosphatase, non-receptor type 1 [Homo
sapiens]
Length = 435
Score = 180 bits (457), Expect = 4e-45
Identities = 99/268 (36%), Positives = 147/268 (54%), Gaps = 14/268 (5%)
Query: 466 ESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL-QGNEDYINASY 524
+SG+ ++ + + AKLP+N ++NRY+DV P+D +R+ L Q + DYINAS
Sbjct: 12 KSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASL 71
Query: 525 VNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD 584
+ ME YI TQGPLP+TC FW++VW+QK +VML + E+G KC QYWP
Sbjct: 72 IKME----EAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQ 127
Query: 585 PPD---VMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDD 641
+ + + SED Y R++ + N T E + H Y WPD GVP+
Sbjct: 128 KEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPES 187
Query: 642 SSDFLEFVNYVR---SLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIV 698
+ FL F+ VR SL + PV+VHCSAGIGR+G +T + L ++ +DI
Sbjct: 188 PASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIK 247
Query: 699 R---KMRDQRAMMVQTSSQYKFVCEAIL 723
+ +MR R ++QT+ Q +F A++
Sbjct: 248 KVLLEMRKFRMGLIQTADQLRFSYLAVI 275
>gi|241896926 protein tyrosine phosphatase, receptor type, H isoform
2 precursor [Homo sapiens]
Length = 937
Score = 179 bits (455), Expect = 6e-45
Identities = 95/248 (38%), Positives = 135/248 (54%), Gaps = 12/248 (4%)
Query: 489 AKLPQNLDKNRYKDVLPYDTTRVLL-----QGNEDYINASYVNMEIPAANLVNKYIATQG 543
A +N KNRY++VLPYD +RV L + DYINAS++ P ++IATQG
Sbjct: 661 ASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFM----PGLWSPQEFIATQG 716
Query: 544 PLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDC 603
PLP T FW++VW+Q+ +VMLT E GR KC YWP HG + E+
Sbjct: 717 PLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEV 776
Query: 604 TIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVR---SLRVDSE 660
+ RE+L+ + + +V Y AWPDHGVP L F +R ++
Sbjct: 777 MENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGG 836
Query: 661 PVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCE 720
P +VHCSAG+GRTG L+ ++ + + + P VRKMR+ R +MVQT +QY F+ +
Sbjct: 837 PPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQ 896
Query: 721 AILRVYEE 728
ILR ++
Sbjct: 897 CILRFLQQ 904
>gi|241896924 protein tyrosine phosphatase, receptor type, H isoform 1
precursor [Homo sapiens]
Length = 1115
Score = 179 bits (455), Expect = 6e-45
Identities = 95/248 (38%), Positives = 135/248 (54%), Gaps = 12/248 (4%)
Query: 489 AKLPQNLDKNRYKDVLPYDTTRVLL-----QGNEDYINASYVNMEIPAANLVNKYIATQG 543
A +N KNRY++VLPYD +RV L + DYINAS++ P ++IATQG
Sbjct: 839 ASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFM----PGLWSPQEFIATQG 894
Query: 544 PLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDC 603
PLP T FW++VW+Q+ +VMLT E GR KC YWP HG + E+
Sbjct: 895 PLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEV 954
Query: 604 TIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVR---SLRVDSE 660
+ RE+L+ + + +V Y AWPDHGVP L F +R ++
Sbjct: 955 MENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGG 1014
Query: 661 PVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCE 720
P +VHCSAG+GRTG L+ ++ + + + P VRKMR+ R +MVQT +QY F+ +
Sbjct: 1015 PPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQ 1074
Query: 721 AILRVYEE 728
ILR ++
Sbjct: 1075 CILRFLQQ 1082
>gi|157952215 protein tyrosine phosphatase, receptor type, B isoform a
[Homo sapiens]
Length = 2215
Score = 177 bits (448), Expect = 4e-44
Identities = 102/286 (35%), Positives = 149/286 (52%), Gaps = 16/286 (5%)
Query: 447 CPEGGDTLEGSMAQLKKGLESGTVLI-QFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLP 505
CP + EG +L+ +S +L ++E+L + A LP+N KNRY ++LP
Sbjct: 1899 CPIKINQFEGHFMKLQA--DSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILP 1956
Query: 506 YDTTRVLLQGNED-----YINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQK 560
YD TRV L +D YINASY IP N +YI TQGPLP T FW++VW+Q
Sbjct: 1957 YDATRVKLSNVDDDPCSDYINASY----IPGNNFRREYIVTQGPLPGTKDDFWKMVWEQN 2012
Query: 561 LSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTG 620
+ IVM+T E+GR KC YWP D + +G +Q SE + RE + +
Sbjct: 2013 VHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQL 2072
Query: 621 EEH-TVTHLQYVAWPDHGVPDDSSDFLEFVNYVR---SLRVDSEPVLVHCSAGIGRTGVL 676
+ H + H Y WPDHGVP+ + ++FV VR + + P +VHCSAG+GRTG
Sbjct: 2073 DAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTF 2132
Query: 677 VTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAI 722
+ ++ + + + V +R R MVQT QY ++ + +
Sbjct: 2133 IALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 2178
>gi|157952213 protein tyrosine phosphatase, receptor type, B isoform b
precursor [Homo sapiens]
Length = 1997
Score = 177 bits (448), Expect = 4e-44
Identities = 102/286 (35%), Positives = 149/286 (52%), Gaps = 16/286 (5%)
Query: 447 CPEGGDTLEGSMAQLKKGLESGTVLI-QFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLP 505
CP + EG +L+ +S +L ++E+L + A LP+N KNRY ++LP
Sbjct: 1681 CPIKINQFEGHFMKLQA--DSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILP 1738
Query: 506 YDTTRVLLQGNED-----YINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQK 560
YD TRV L +D YINASY IP N +YI TQGPLP T FW++VW+Q
Sbjct: 1739 YDATRVKLSNVDDDPCSDYINASY----IPGNNFRREYIVTQGPLPGTKDDFWKMVWEQN 1794
Query: 561 LSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTG 620
+ IVM+T E+GR KC YWP D + +G +Q SE + RE + +
Sbjct: 1795 VHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQL 1854
Query: 621 EEH-TVTHLQYVAWPDHGVPDDSSDFLEFVNYVR---SLRVDSEPVLVHCSAGIGRTGVL 676
+ H + H Y WPDHGVP+ + ++FV VR + + P +VHCSAG+GRTG
Sbjct: 1855 DAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTF 1914
Query: 677 VTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAI 722
+ ++ + + + V +R R MVQT QY ++ + +
Sbjct: 1915 IALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 1960
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 173 bits (439), Expect = 5e-43
Identities = 105/277 (37%), Positives = 151/277 (54%), Gaps = 19/277 (6%)
Query: 458 MAQLKKGLESGTVLIQFEQLYRKKPGLAITF--AKLPQNLDKNRYKDVLPYDTTRVLLQG 515
MA+ + L++ L ++ PG T+ + L N KNRY +V+ YD +RV+LQ
Sbjct: 935 MAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQP 994
Query: 516 NE-----DYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTL 570
E DYINA+YV+ N YIATQGPLP T FW++VW+Q+ + IVM+T L
Sbjct: 995 IEGIMGSDYINANYVD----GYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRL 1050
Query: 571 TERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQY 630
E+ R KC QYWP+ +G + + R + + E+ V Q+
Sbjct: 1051 EEKSRIKCDQYWPN-RGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1109
Query: 631 VAWPDHGVPDDSSDFLEFVNYVRSLR-VDSEPVLVHCSAGIGRTGVLVTMETAMCLTERN 689
AWPDHGVP+ + FL F+ V++ D+ P++VHCSAG+GRTG + ++ + ER
Sbjct: 1110 TAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVID---AMLERI 1166
Query: 690 LPIYPLDI---VRKMRDQRAMMVQTSSQYKFVCEAIL 723
P +D+ V MR QR MVQT QY F+ EA+L
Sbjct: 1167 KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALL 1203
Score = 171 bits (434), Expect = 2e-42
Identities = 97/275 (35%), Positives = 145/275 (52%), Gaps = 14/275 (5%)
Query: 458 MAQLKKGLESGTVLIQFEQLYRKKPGLA-ITFAKLPQNLDKNRYKDVLPYDTTRVLLQG- 515
+AQ++ G + ++F++L K + A LP N KNR +++PY++TRV LQ
Sbjct: 1225 LAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1284
Query: 516 ----NEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLT 571
DYINAS+++ YIATQGPL T FW+++W+ +++VMLT L
Sbjct: 1285 RGVEGSDYINASFID----GYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLR 1340
Query: 572 ERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYV 631
E GR KCHQYWP + F + +E Y+ RE VT+ + G+ TV Q+
Sbjct: 1341 EMGREKCHQYWPAERSA-RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT 1399
Query: 632 AWPDHGVPDDSSDFLEFVNYVRSLRV---DSEPVLVHCSAGIGRTGVLVTMETAMCLTER 688
WP+ GVP F++F+ V + P+ VHCSAG+GRTGV +T+ +
Sbjct: 1400 DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1459
Query: 689 NLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL 723
+ V+ +R QR MVQT +Y+F +A L
Sbjct: 1460 EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAAL 1494
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 173 bits (439), Expect = 5e-43
Identities = 105/277 (37%), Positives = 151/277 (54%), Gaps = 19/277 (6%)
Query: 458 MAQLKKGLESGTVLIQFEQLYRKKPGLAITF--AKLPQNLDKNRYKDVLPYDTTRVLLQG 515
MA+ + L++ L ++ PG T+ + L N KNRY +V+ YD +RV+LQ
Sbjct: 1340 MAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQP 1399
Query: 516 NE-----DYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTL 570
E DYINA+YV+ N YIATQGPLP T FW++VW+Q+ + IVM+T L
Sbjct: 1400 IEGIMGSDYINANYVD----GYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRL 1455
Query: 571 TERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQY 630
E+ R KC QYWP+ +G + + R + + E+ V Q+
Sbjct: 1456 EEKSRIKCDQYWPN-RGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1514
Query: 631 VAWPDHGVPDDSSDFLEFVNYVRSLR-VDSEPVLVHCSAGIGRTGVLVTMETAMCLTERN 689
AWPDHGVP+ + FL F+ V++ D+ P++VHCSAG+GRTG + ++ + ER
Sbjct: 1515 TAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVID---AMLERI 1571
Query: 690 LPIYPLDI---VRKMRDQRAMMVQTSSQYKFVCEAIL 723
P +D+ V MR QR MVQT QY F+ EA+L
Sbjct: 1572 KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALL 1608
Score = 171 bits (434), Expect = 2e-42
Identities = 97/275 (35%), Positives = 145/275 (52%), Gaps = 14/275 (5%)
Query: 458 MAQLKKGLESGTVLIQFEQLYRKKPGLA-ITFAKLPQNLDKNRYKDVLPYDTTRVLLQG- 515
+AQ++ G + ++F++L K + A LP N KNR +++PY++TRV LQ
Sbjct: 1630 LAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1689
Query: 516 ----NEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLT 571
DYINAS+++ YIATQGPL T FW+++W+ +++VMLT L
Sbjct: 1690 RGVEGSDYINASFID----GYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLR 1745
Query: 572 ERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYV 631
E GR KCHQYWP + F + +E Y+ RE VT+ + G+ TV Q+
Sbjct: 1746 EMGREKCHQYWPAERSA-RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT 1804
Query: 632 AWPDHGVPDDSSDFLEFVNYVRSLRV---DSEPVLVHCSAGIGRTGVLVTMETAMCLTER 688
WP+ GVP F++F+ V + P+ VHCSAG+GRTGV +T+ +
Sbjct: 1805 DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1864
Query: 689 NLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL 723
+ V+ +R QR MVQT +Y+F +A L
Sbjct: 1865 EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAAL 1899
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,577,356
Number of Sequences: 37866
Number of extensions: 1302322
Number of successful extensions: 4837
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 195
Number of HSP's successfully gapped in prelim test: 119
Number of HSP's that attempted gapping in prelim test: 3911
Number of HSP's gapped (non-prelim): 520
length of query: 737
length of database: 18,247,518
effective HSP length: 110
effective length of query: 627
effective length of database: 14,082,258
effective search space: 8829575766
effective search space used: 8829575766
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.