Guide to the Human Genome
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Search of human proteins with 223941885

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|223941885 protein tyrosine phosphatase, non-receptor type 3
isoform 4 [Homo sapiens]
         (737 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|223941885 protein tyrosine phosphatase, non-receptor type 3 i...  1507   0.0  
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i...  1507   0.0  
gi|223941882 protein tyrosine phosphatase, non-receptor type 3 i...  1485   0.0  
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i...  1485   0.0  
gi|223941891 protein tyrosine phosphatase, non-receptor type 3 i...  1188   0.0  
gi|223941888 protein tyrosine phosphatase, non-receptor type 3 i...  1166   0.0  
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho...   749   0.0  
gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [...   214   2e-55
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ...   194   2e-49
gi|4506291 protein tyrosine phosphatase, non-receptor type 2 iso...   191   3e-48
gi|18104982 protein tyrosine phosphatase, non-receptor type 2 [H...   191   3e-48
gi|18104980 protein tyrosine phosphatase, non-receptor type 2 is...   191   3e-48
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i...   190   5e-48
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i...   190   5e-48
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i...   190   5e-48
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is...   190   5e-48
gi|109138573 protein tyrosine phosphatase, non-receptor type 20A...   185   1e-46
gi|109138561 protein tyrosine phosphatase, non-receptor type 20A...   185   1e-46
gi|109138557 protein tyrosine phosphatase, non-receptor type 20A...   185   1e-46
gi|108802617 protein tyrosine phosphatase, non-receptor type 20 ...   185   1e-46
gi|108802607 protein tyrosine phosphatase, non-receptor type 20 ...   185   1e-46
gi|108802604 protein tyrosine phosphatase, non-receptor type 20 ...   185   1e-46
gi|148728162 protein tyrosine phosphatase, receptor type, J isof...   182   1e-45
gi|4506289 protein tyrosine phosphatase, non-receptor type 1 [Ho...   180   4e-45
gi|241896926 protein tyrosine phosphatase, receptor type, H isof...   179   6e-45
gi|241896924 protein tyrosine phosphatase, receptor type, H isof...   179   6e-45
gi|157952215 protein tyrosine phosphatase, receptor type, B isof...   177   4e-44
gi|157952213 protein tyrosine phosphatase, receptor type, B isof...   177   4e-44
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ...   173   5e-43
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ...   173   5e-43

>gi|223941885 protein tyrosine phosphatase, non-receptor type 3
           isoform 4 [Homo sapiens]
          Length = 737

 Score = 1507 bits (3901), Expect = 0.0
 Identities = 737/737 (100%), Positives = 737/737 (100%)

Query: 1   MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL 60
           MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL
Sbjct: 1   MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL 60

Query: 61  HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS 120
           HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS
Sbjct: 61  HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS 120

Query: 121 FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK 180
           FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK
Sbjct: 121 FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK 180

Query: 181 KLLPQEKNVLSQYWTMGSRNTKKRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTY 240
           KLLPQEKNVLSQYWTMGSRNTKKRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTY
Sbjct: 181 KLLPQEKNVLSQYWTMGSRNTKKRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTY 240

Query: 241 KGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQ 300
           KGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQ
Sbjct: 241 KGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQ 300

Query: 301 LLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLV 360
           LLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLV
Sbjct: 301 LLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLV 360

Query: 361 VSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRR 420
           VSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRR
Sbjct: 361 VSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRR 420

Query: 421 RAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRK 480
           RAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRK
Sbjct: 421 RAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRK 480

Query: 481 KPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIA 540
           KPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIA
Sbjct: 481 KPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIA 540

Query: 541 TQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQS 600
           TQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQS
Sbjct: 541 TQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQS 600

Query: 601 EDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSE 660
           EDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSE
Sbjct: 601 EDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSE 660

Query: 661 PVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCE 720
           PVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCE
Sbjct: 661 PVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCE 720

Query: 721 AILRVYEEGLVQMLDPS 737
           AILRVYEEGLVQMLDPS
Sbjct: 721 AILRVYEEGLVQMLDPS 737


>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
           isoform 2 [Homo sapiens]
          Length = 868

 Score = 1507 bits (3901), Expect = 0.0
 Identities = 737/737 (100%), Positives = 737/737 (100%)

Query: 1   MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL 60
           MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL
Sbjct: 132 MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL 191

Query: 61  HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS 120
           HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS
Sbjct: 192 HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS 251

Query: 121 FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK 180
           FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK
Sbjct: 252 FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK 311

Query: 181 KLLPQEKNVLSQYWTMGSRNTKKRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTY 240
           KLLPQEKNVLSQYWTMGSRNTKKRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTY
Sbjct: 312 KLLPQEKNVLSQYWTMGSRNTKKRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTY 371

Query: 241 KGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQ 300
           KGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQ
Sbjct: 372 KGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQ 431

Query: 301 LLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLV 360
           LLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLV
Sbjct: 432 LLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLV 491

Query: 361 VSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRR 420
           VSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRR
Sbjct: 492 VSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRR 551

Query: 421 RAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRK 480
           RAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRK
Sbjct: 552 RAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRK 611

Query: 481 KPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIA 540
           KPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIA
Sbjct: 612 KPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIA 671

Query: 541 TQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQS 600
           TQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQS
Sbjct: 672 TQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQS 731

Query: 601 EDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSE 660
           EDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSE
Sbjct: 732 EDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSE 791

Query: 661 PVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCE 720
           PVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCE
Sbjct: 792 PVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCE 851

Query: 721 AILRVYEEGLVQMLDPS 737
           AILRVYEEGLVQMLDPS
Sbjct: 852 AILRVYEEGLVQMLDPS 868


>gi|223941882 protein tyrosine phosphatase, non-receptor type 3
           isoform 3 [Homo sapiens]
          Length = 782

 Score = 1485 bits (3845), Expect = 0.0
 Identities = 737/782 (94%), Positives = 737/782 (94%), Gaps = 45/782 (5%)

Query: 1   MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL 60
           MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL
Sbjct: 1   MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL 60

Query: 61  HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS 120
           HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS
Sbjct: 61  HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS 120

Query: 121 FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK 180
           FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK
Sbjct: 121 FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK 180

Query: 181 KLLPQEKNVLSQYWTMGSRNTKK------------------------------------- 203
           KLLPQEKNVLSQYWTMGSRNTKK                                     
Sbjct: 181 KLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSR 240

Query: 204 --------RSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQ 255
                   RSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQ
Sbjct: 241 SPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQ 300

Query: 256 NRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTE 315
           NRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTE
Sbjct: 301 NRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTE 360

Query: 316 DASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIP 375
           DASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIP
Sbjct: 361 DASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIP 420

Query: 376 KLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDEL 435
           KLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDEL
Sbjct: 421 KLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDEL 480

Query: 436 NQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNL 495
           NQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNL
Sbjct: 481 NQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNL 540

Query: 496 DKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQV 555
           DKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQV
Sbjct: 541 DKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQV 600

Query: 556 VWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVT 615
           VWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVT
Sbjct: 601 VWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVT 660

Query: 616 NTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGV 675
           NTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGV
Sbjct: 661 NTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGV 720

Query: 676 LVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLD 735
           LVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLD
Sbjct: 721 LVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLD 780

Query: 736 PS 737
           PS
Sbjct: 781 PS 782


>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
           isoform 1 [Homo sapiens]
          Length = 913

 Score = 1485 bits (3845), Expect = 0.0
 Identities = 737/782 (94%), Positives = 737/782 (94%), Gaps = 45/782 (5%)

Query: 1   MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL 60
           MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL
Sbjct: 132 MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL 191

Query: 61  HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS 120
           HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS
Sbjct: 192 HEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTS 251

Query: 121 FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK 180
           FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK
Sbjct: 252 FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAK 311

Query: 181 KLLPQEKNVLSQYWTMGSRNTKK------------------------------------- 203
           KLLPQEKNVLSQYWTMGSRNTKK                                     
Sbjct: 312 KLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSR 371

Query: 204 --------RSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQ 255
                   RSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQ
Sbjct: 372 SPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQ 431

Query: 256 NRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTE 315
           NRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTE
Sbjct: 432 NRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTE 491

Query: 316 DASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIP 375
           DASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIP
Sbjct: 492 DASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIP 551

Query: 376 KLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDEL 435
           KLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDEL
Sbjct: 552 KLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDEL 611

Query: 436 NQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNL 495
           NQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNL
Sbjct: 612 NQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNL 671

Query: 496 DKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQV 555
           DKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQV
Sbjct: 672 DKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQV 731

Query: 556 VWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVT 615
           VWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVT
Sbjct: 732 VWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVT 791

Query: 616 NTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGV 675
           NTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGV
Sbjct: 792 NTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGV 851

Query: 676 LVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLD 735
           LVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLD
Sbjct: 852 LVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLD 911

Query: 736 PS 737
           PS
Sbjct: 912 PS 913


>gi|223941891 protein tyrosine phosphatase, non-receptor type 3
           isoform 6 [Homo sapiens]
          Length = 581

 Score = 1188 bits (3073), Expect = 0.0
 Identities = 581/581 (100%), Positives = 581/581 (100%)

Query: 157 MLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKRSPRLRHEIRKPR 216
           MLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKRSPRLRHEIRKPR
Sbjct: 1   MLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKRSPRLRHEIRKPR 60

Query: 217 HSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQ 276
           HSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQ
Sbjct: 61  HSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQ 120

Query: 277 KSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIR 336
           KSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIR
Sbjct: 121 KSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIR 180

Query: 337 ITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTH 396
           ITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTH
Sbjct: 181 ITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTH 240

Query: 397 DQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEG 456
           DQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEG
Sbjct: 241 DQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEG 300

Query: 457 SMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGN 516
           SMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGN
Sbjct: 301 SMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGN 360

Query: 517 EDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRT 576
           EDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRT
Sbjct: 361 EDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRT 420

Query: 577 KCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDH 636
           KCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDH
Sbjct: 421 KCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDH 480

Query: 637 GVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLD 696
           GVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLD
Sbjct: 481 GVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLD 540

Query: 697 IVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLDPS 737
           IVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLDPS
Sbjct: 541 IVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLDPS 581


>gi|223941888 protein tyrosine phosphatase, non-receptor type 3
           isoform 5 [Homo sapiens]
          Length = 626

 Score = 1166 bits (3017), Expect = 0.0
 Identities = 581/626 (92%), Positives = 581/626 (92%), Gaps = 45/626 (7%)

Query: 157 MLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKK------------- 203
           MLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKK             
Sbjct: 1   MLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGG 60

Query: 204 --------------------------------RSPRLRHEIRKPRHSSADNLANEMTYIT 231
                                           RSPRLRHEIRKPRHSSADNLANEMTYIT
Sbjct: 61  MVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYIT 120

Query: 232 ETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGS 291
           ETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGS
Sbjct: 121 ETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGS 180

Query: 292 CSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKG 351
           CSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKG
Sbjct: 181 CSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKG 240

Query: 352 GVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHS 411
           GVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHS
Sbjct: 241 GVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHS 300

Query: 412 RELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVL 471
           RELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVL
Sbjct: 301 RELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVL 360

Query: 472 IQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPA 531
           IQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPA
Sbjct: 361 IQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPA 420

Query: 532 ANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNH 591
           ANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNH
Sbjct: 421 ANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNH 480

Query: 592 GGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNY 651
           GGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNY
Sbjct: 481 GGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNY 540

Query: 652 VRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQT 711
           VRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQT
Sbjct: 541 VRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQT 600

Query: 712 SSQYKFVCEAILRVYEEGLVQMLDPS 737
           SSQYKFVCEAILRVYEEGLVQMLDPS
Sbjct: 601 SSQYKFVCEAILRVYEEGLVQMLDPS 626


>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
           sapiens]
          Length = 926

 Score =  749 bits (1935), Expect = 0.0
 Identities = 387/791 (48%), Positives = 523/791 (66%), Gaps = 55/791 (6%)

Query: 2   DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 61
           DI  GRL CP N+A +LAS+AVQS  GDY+ S +  GYLSD  FIP+Q +DF  ++  LH
Sbjct: 133 DILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLH 192

Query: 62  EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 121
           +QH GL  +EAE  Y+N ARTL+ YGVE H  RD  N ++MIG+ S G+ +Y+  +  + 
Sbjct: 193 QQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNT 252

Query: 122 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 181
           +PW+ I+KISFK K+FFI  R++  ESRE ++ FNM+NYR+CKNLWK+CVEHHTFF+  +
Sbjct: 253 FPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDR 312

Query: 182 LLPQEKNVLSQYWTMGSRNT-------------KKRSPRLRHEIRKP------------- 215
            LP +KN  + Y+T+GS+               K+++ + R   R P             
Sbjct: 313 PLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKLMDWEV 372

Query: 216 --RHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSY 273
             R+S +D+     +  + +      ++ S   Q+       +     + +   +P++ +
Sbjct: 373 VSRNSISDDRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHLVDHMVHTSPSEVF 432

Query: 274 LTQKSSSSV---------SPSSNAPGSCSPDGVD--QQLLDDFHRVTKGGSTEDASQYYC 322
           + Q+S SS          SPS   PG   P  +   Q   + ++++    S +D   +  
Sbjct: 433 VNQRSPSSTQANSIVLESSPSQETPGDGKPPALPPKQSKKNSWNQIHYSHSQQDLESHIN 492

Query: 323 DKND----------NGD---SYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESP 369
           +  D          NG      LVLIR+ PDE+G+FGFN+KGG DQKMP++VSR+ P +P
Sbjct: 493 ETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTP 552

Query: 370 ADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADF 429
           AD C+P+LNEGDQ+VLINGRDI+EHTHDQVV+FIKAS E HS EL L++R  AV    + 
Sbjct: 553 ADLCVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCERHSGELMLLVRPNAVYDVVEE 612

Query: 430 KSEDELN-QLFPE-AIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAIT 487
           K E+E + Q  PE A      +   +L  SM QL +GL +GTVL QF+QLYRKKPG+ ++
Sbjct: 613 KLENEPDFQYIPEKAPLDSVHQDDHSLRESMIQLAEGLITGTVLTQFDQLYRKKPGMTMS 672

Query: 488 FAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPH 547
            AKLPQN+ KNRY+D+ PYD TRV+L+GNEDYINA+Y+NMEIP+++++N+YIA QGPLPH
Sbjct: 673 CAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINMEIPSSSIINQYIACQGPLPH 732

Query: 548 TCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAY 607
           TC  FWQ+ W+Q  S++VMLTT  ERGR KCHQYWP+P    ++G + + C SE+   AY
Sbjct: 733 TCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAY 792

Query: 608 VSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV-DSEPVLVHC 666
           + R+M + N +  E   +T +QY+AWPDHGVPDDSSDFL+FV +VR+ R    EPV+VHC
Sbjct: 793 IFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHC 852

Query: 667 SAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY 726
           SAGIGRTGVL+TMETAMCL E N P+YPLDIVR MRDQRAMM+QT SQY+FVCEAIL+VY
Sbjct: 853 SAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVY 912

Query: 727 EEGLVQMLDPS 737
           EEG V+ L  S
Sbjct: 913 EEGFVKPLTTS 923


>gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [Homo
            sapiens]
          Length = 1187

 Score =  214 bits (546), Expect = 2e-55
 Identities = 110/282 (39%), Positives = 168/282 (59%), Gaps = 20/282 (7%)

Query: 461  LKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----QGN 516
            LKK LE G V  ++EQ+ +KK     + A LP+N +++R ++V+PY+  RV L    + N
Sbjct: 900  LKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENN 959

Query: 517  EDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRT 576
              YINAS++ + +  A     YIATQGPLPHTC  FWQ+VW+Q +++I M+T   E GRT
Sbjct: 960  TGYINASHIKVVVGGAEW--HYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017

Query: 577  KCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAW 633
            K H+YWP          +G F +  +    ++ Y +  + V +  +G+E TV HLQY  W
Sbjct: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077

Query: 634  PDHGVPDDSSDFLEFVNYVRSLRVDSE-----------PVLVHCSAGIGRTGVLVTMETA 682
            PDHG P+D   FL ++  ++S+R  +            P++VHCSAG+GRTGVL+  E  
Sbjct: 1078 PDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELM 1137

Query: 683  MCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 724
            +   E N  +    ++R +R+QR  M+QT +QYKFV + +++
Sbjct: 1138 IYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 70/303 (23%), Positives = 130/303 (42%), Gaps = 22/303 (7%)

Query: 2   DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQN-------EDFL 54
           D+ EGRL C L+  + LA  AVQ+ FGDYN       +L +    P          E+  
Sbjct: 125 DVLEGRLRCTLDQVIRLAGLAVQADFGDYNQ-FDSQDFLREYVLFPMDLALEEAVLEELT 183

Query: 55  TKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYR 114
            KV   H+ HSG+  +EAE  YIN    LD +G E+   +D H   + +GI   G+ V  
Sbjct: 184 QKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFVRN 243

Query: 115 KYICTS-FYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEH 173
           +    +  Y W ++  I+  +    +     +  ++E    F+  +  + K + +     
Sbjct: 244 RIGRQAVIYRWNDMGNITHNKSTILV-----ELINKEETALFHTDDIENAKYISRLFATR 298

Query: 174 HTFFQAKKLLPQEKN---VLSQYWTMGSRNTKKRSPRLRH--EIRKPRHSSADNLANEMT 228
           H F++  K+  ++ N    + +  T    +  ++ P +     ++   H S  + + +  
Sbjct: 299 HKFYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQPYILPPVHVQCGEHYSETHTSQDSI 358

Query: 229 YITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNA 288
           +    E ++     SL     +  V+        S++  N +QS++    +S VS + + 
Sbjct: 359 FHGNEEALYCNSHNSLDLNYLNGTVTNGSVCSVHSVNSLNCSQSFI---QASPVSSNLSI 415

Query: 289 PGS 291
           PGS
Sbjct: 416 PGS 418


>gi|150418005 protein tyrosine phosphatase, non-receptor type 21 [Homo
            sapiens]
          Length = 1174

 Score =  194 bits (494), Expect = 2e-49
 Identities = 106/283 (37%), Positives = 166/283 (58%), Gaps = 22/283 (7%)

Query: 461  LKKGLESGTVLIQFEQLYRKK--PGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----Q 514
            L++ LE G V  ++E++ +K+   G   T A+LP+N ++NR++DVLPYD  RV L    +
Sbjct: 887  LEQRLEQGMVFTEYERILKKRLVDGECST-ARLPENAERNRFQDVLPYDDVRVELVPTKE 945

Query: 515  GNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERG 574
             N  YINAS++ + +  + +   YIATQGPL +TC  FWQ+VW+Q +++I M+T   E G
Sbjct: 946  NNTGYINASHIKVSV--SGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGG 1003

Query: 575  RTKCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYV 631
            R K  +YWP      + + +G F I  +    +  Y +  + + +  TG+E TV HLQY 
Sbjct: 1004 REKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYT 1063

Query: 632  AWPDHGVPDDSSDFLEFVNYVRSLR----------VDSEPVLVHCSAGIGRTGVLVTMET 681
             WP+HG P+D   FL ++  ++S+R            + P+LVHCSAG+GRTGV++  E 
Sbjct: 1064 DWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEI 1123

Query: 682  AMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR 724
             +   E N  +    ++  +R QR M+VQT  QY FV   +++
Sbjct: 1124 MIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ 1166



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 81/321 (25%), Positives = 135/321 (42%), Gaps = 44/321 (13%)

Query: 2   DICEGRLTCPLNSAVVLASYAVQSHFGDYNS----------SIHHPGYLSDSHFIPDQNE 51
           DI EG + C L  A+ LA  AVQ+ FGD++           ++   G+L D   +    E
Sbjct: 127 DILEGSIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKVL----E 182

Query: 52  DFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVA 111
           +   KV  LH+++ GL   +AE  Y+     +D YG E +  +D    D+ IG    G+ 
Sbjct: 183 EATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIF 242

Query: 112 V-YRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSC 170
           V ++       + W +I  +S  +  F +     +  ++E  + F   +  + K +W+ C
Sbjct: 243 VKHKNGRHPVVFRWHDIANMSHNKSFFAL-----ELANKEETIQFQTEDMETAKYIWRLC 297

Query: 171 VEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKRS------------PRLRH--EIRKPR 216
           V  H F++  +   Q + V      +  R++ + S            P+L +     +P 
Sbjct: 298 VARHKFYRLNQCNLQTQTVTVN--PIRRRSSSRMSLPKPQPYVMPPPPQLHYNGHYTEPY 355

Query: 217 HSSADNL--ANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYL 274
            SS DNL   N+  Y   ++      +  L  +  +  V    S +    S NNP Q YL
Sbjct: 356 ASSQDNLFVPNQNGYYCHSQTSLDRAQIDLNGRIRNGSVYSAHSTN----SLNNP-QPYL 410

Query: 275 TQKSSSSVSPSSNAPGSCSPD 295
            Q S  S +PS        PD
Sbjct: 411 -QPSPMSSNPSITGSDVMRPD 430


>gi|4506291 protein tyrosine phosphatase, non-receptor type 2
           isoform 1 [Homo sapiens]
          Length = 415

 Score =  191 bits (484), Expect = 3e-48
 Identities = 101/241 (41%), Positives = 137/241 (56%), Gaps = 10/241 (4%)

Query: 489 AKLPQNLDKNRYKDVLPYDTTRVLLQGNE-DYINASYVNMEIPAANLVNKYIATQGPLPH 547
           AK P+N ++NRY+DV PYD +RV LQ  E DYINAS V++E         YI TQGPLP+
Sbjct: 37  AKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIE----EAQRSYILTQGPLPN 92

Query: 548 TCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP--DPPDVMNHGGFHIQCQSEDCTI 605
           TC  FW +VW QK   +VML  + E+   KC QYWP  D   +    GF ++  SED   
Sbjct: 93  TCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKS 152

Query: 606 AYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVR---SLRVDSEPV 662
            Y    + + N  +GE  T++H  Y  WPD GVP+  + FL F+  VR   SL  D  P 
Sbjct: 153 YYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPA 212

Query: 663 LVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAI 722
           ++HCSAGIGR+G    ++T + L E+   I    ++  MR  R  ++QT  Q +F   AI
Sbjct: 213 VIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAI 272

Query: 723 L 723
           +
Sbjct: 273 I 273


>gi|18104982 protein tyrosine phosphatase, non-receptor type 2 [Homo
           sapiens]
          Length = 353

 Score =  191 bits (484), Expect = 3e-48
 Identities = 101/241 (41%), Positives = 137/241 (56%), Gaps = 10/241 (4%)

Query: 489 AKLPQNLDKNRYKDVLPYDTTRVLLQGNE-DYINASYVNMEIPAANLVNKYIATQGPLPH 547
           AK P+N ++NRY+DV PYD +RV LQ  E DYINAS V++E         YI TQGPLP+
Sbjct: 37  AKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIE----EAQRSYILTQGPLPN 92

Query: 548 TCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP--DPPDVMNHGGFHIQCQSEDCTI 605
           TC  FW +VW QK   +VML  + E+   KC QYWP  D   +    GF ++  SED   
Sbjct: 93  TCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKS 152

Query: 606 AYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVR---SLRVDSEPV 662
            Y    + + N  +GE  T++H  Y  WPD GVP+  + FL F+  VR   SL  D  P 
Sbjct: 153 YYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPA 212

Query: 663 LVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAI 722
           ++HCSAGIGR+G    ++T + L E+   I    ++  MR  R  ++QT  Q +F   AI
Sbjct: 213 VIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAI 272

Query: 723 L 723
           +
Sbjct: 273 I 273


>gi|18104980 protein tyrosine phosphatase, non-receptor type 2
           isoform 2 [Homo sapiens]
          Length = 387

 Score =  191 bits (484), Expect = 3e-48
 Identities = 101/241 (41%), Positives = 137/241 (56%), Gaps = 10/241 (4%)

Query: 489 AKLPQNLDKNRYKDVLPYDTTRVLLQGNE-DYINASYVNMEIPAANLVNKYIATQGPLPH 547
           AK P+N ++NRY+DV PYD +RV LQ  E DYINAS V++E         YI TQGPLP+
Sbjct: 37  AKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIE----EAQRSYILTQGPLPN 92

Query: 548 TCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP--DPPDVMNHGGFHIQCQSEDCTI 605
           TC  FW +VW QK   +VML  + E+   KC QYWP  D   +    GF ++  SED   
Sbjct: 93  TCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKS 152

Query: 606 AYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVR---SLRVDSEPV 662
            Y    + + N  +GE  T++H  Y  WPD GVP+  + FL F+  VR   SL  D  P 
Sbjct: 153 YYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPA 212

Query: 663 LVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAI 722
           ++HCSAGIGR+G    ++T + L E+   I    ++  MR  R  ++QT  Q +F   AI
Sbjct: 213 VIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAI 272

Query: 723 L 723
           +
Sbjct: 273 I 273


>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
            isoform 4 [Homo sapiens]
          Length = 2490

 Score =  190 bits (482), Expect = 5e-48
 Identities = 110/299 (36%), Positives = 156/299 (52%), Gaps = 5/299 (1%)

Query: 429  FKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITF 488
            F + DEL  L    + P     G  L+  +  L+  L+ G    + E L   KP      
Sbjct: 2177 FLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLI 2236

Query: 489  AKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHT 548
             +  +N  KNRYK++LPYD TRV L     YINAS++ + +     V  YIA QGPLP T
Sbjct: 2237 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFV--YIACQGPLPTT 2294

Query: 549  CAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD--PPDVMNHGGFHIQCQSEDCTIA 606
               FWQ++W+QK ++I M+T   E  + KC +YWP+      M      +          
Sbjct: 2295 VGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKG 2354

Query: 607  YVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHC 666
            +V R M + + QT E   ++HL + AWPDH  P    D L F++Y+R +   S P++ HC
Sbjct: 2355 FVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH-RSGPIITHC 2413

Query: 667  SAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 725
            SAGIGR+G L+ ++  + L  ++L     D+VR MR QR  MVQT  QY F  + IL V
Sbjct: 2414 SAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2472



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 99/492 (20%), Positives = 184/492 (37%), Gaps = 93/492 (18%)

Query: 2    DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFL------T 55
            DI E R+ C   ++++LAS A+Q+ +GDY   +H   Y    H++P +  + L       
Sbjct: 686  DILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKE 745

Query: 56   KVESLHEQHSGLKQSEAESCYINIARTLDFYGVELH--SGRDLHNLDLMIGIASAGVAVY 113
            ++  LH  + G  + E E  ++ + + L  YGV  H           +++G+ S GV V+
Sbjct: 746  ELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVF 805

Query: 114  RKY----ICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKS 169
              +         +PW    KISF +KK  +   Q  ++  +H   F   N + C+ L   
Sbjct: 806  EVHNGVRTLVLRFPWRETKKISFSKKKITL---QNTSDGIKH--GFQTDNSKICQYLLHL 860

Query: 170  CVEHHTF-------------------------FQAKKLLPQEKNVLSQYWTMGSRNTKKR 204
            C   H F                          QA+ +            ++ S    K 
Sbjct: 861  CSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTLNKL 920

Query: 205  SPR---LRHEIRK-----------PRHSSADNLANEMTYITETEDVFYTY----KGSLAP 246
            + R   ++ EI K           P  +S+    ++ ++  +  ++  +Y    + SL P
Sbjct: 921  AVRPLSVQAEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYP 980

Query: 247  QDSDSEVSQNRSP-----------HQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPD 295
               +  V+    P           HQ S S+           +S SV+  + +P     +
Sbjct: 981  HRKNVIVNMEPPPQTVAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHE 1040

Query: 296  GVDQQLLDDFHR----VTKGGSTEDASQYYCDKND----------NGDSYLVLIRITPDE 341
                 + D        +T   S   +SQ    +ND          + +  + L+ +  D 
Sbjct: 1041 SDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDA 1100

Query: 342  DGKFGFNLKGGVDQ---KMPLVVSRINPESPADT--CIPKLNEGDQIVLINGRDISEHTH 396
                GF + GG       + + +S + P  PAD   C   L  GD+++ +N   +   +H
Sbjct: 1101 KYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGC---LKPGDRLISVNSVSLEGVSH 1157

Query: 397  DQVVMFIKASRE 408
               +  ++ + E
Sbjct: 1158 HAAIEILQNAPE 1169



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 56/256 (21%), Positives = 103/256 (40%), Gaps = 34/256 (13%)

Query: 186  EKNVLSQYWTMGSRNTKK-RSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSL 244
            E++  S    M  ++ K+ +SP  R        S  D+L      +T   ++  +   S 
Sbjct: 1630 EQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDL------VTAPANISNSTWSSA 1683

Query: 245  APQDSDSEVSQNRSPHQESLSENNP--AQSYLTQK---------SSSSVSPSSNAPGSC- 292
              Q   + VSQ +S H+   S+ +      Y  QK         S+ S  P   APG   
Sbjct: 1684 LHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSY 1743

Query: 293  --SPDGVDQQLLDDFH--RVTKGGSTEDASQYYCDKNDNGDSYLV----LIRITPDEDGK 344
                +      +D +H   +++    E+ +    D  ++ + + +    LI +   E G 
Sbjct: 1744 QPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGS 1803

Query: 345  FGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIK 404
             GF +  G  +    V   I   + +D    +L  GD+++ +N  D++  TH   V  ++
Sbjct: 1804 LGFTVTKGNQRIGCYVHDVIQDPAKSDG---RLKPGDRLIKVNDTDVTNMTHTDAVNLLR 1860

Query: 405  ASRESHSRELALVIRR 420
            A+    S+ + LVI R
Sbjct: 1861 AA----SKTVRLVIGR 1872


>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
            isoform 3 [Homo sapiens]
          Length = 2294

 Score =  190 bits (482), Expect = 5e-48
 Identities = 110/299 (36%), Positives = 156/299 (52%), Gaps = 5/299 (1%)

Query: 429  FKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITF 488
            F + DEL  L    + P     G  L+  +  L+  L+ G    + E L   KP      
Sbjct: 1981 FLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLI 2040

Query: 489  AKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHT 548
             +  +N  KNRYK++LPYD TRV L     YINAS++ + +     V  YIA QGPLP T
Sbjct: 2041 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFV--YIACQGPLPTT 2098

Query: 549  CAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD--PPDVMNHGGFHIQCQSEDCTIA 606
               FWQ++W+QK ++I M+T   E  + KC +YWP+      M      +          
Sbjct: 2099 VGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKG 2158

Query: 607  YVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHC 666
            +V R M + + QT E   ++HL + AWPDH  P    D L F++Y+R +   S P++ HC
Sbjct: 2159 FVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH-RSGPIITHC 2217

Query: 667  SAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 725
            SAGIGR+G L+ ++  + L  ++L     D+VR MR QR  MVQT  QY F  + IL V
Sbjct: 2218 SAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2276



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 50/187 (26%), Positives = 85/187 (45%), Gaps = 17/187 (9%)

Query: 2   DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFL------T 55
           DI E R+ C   ++++LAS A+Q+ +GDY   +H   Y    H++P +  + L       
Sbjct: 686 DILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKE 745

Query: 56  KVESLHEQHSGLKQSEAESCYINIARTLDFYGVELH--SGRDLHNLDLMIGIASAGVAVY 113
           ++  LH  + G  + E E  ++ + + L  YGV  H           +++G+ S GV V+
Sbjct: 746 ELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVF 805

Query: 114 RKY----ICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKS 169
             +         +PW    KISF +KK  +   Q  ++  +H   F   N + C+ L   
Sbjct: 806 EVHNGVRTLVLRFPWRETKKISFSKKKITL---QNTSDGIKH--GFQTDNSKICQYLLHL 860

Query: 170 CVEHHTF 176
           C   H F
Sbjct: 861 CSYQHKF 867



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 56/256 (21%), Positives = 103/256 (40%), Gaps = 34/256 (13%)

Query: 186  EKNVLSQYWTMGSRNTKK-RSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSL 244
            E++  S    M  ++ K+ +SP  R        S  D+L      +T   ++  +   S 
Sbjct: 1434 EQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDL------VTAPANISNSTWSSA 1487

Query: 245  APQDSDSEVSQNRSPHQESLSENNP--AQSYLTQK---------SSSSVSPSSNAPGSC- 292
              Q   + VSQ +S H+   S+ +      Y  QK         S+ S  P   APG   
Sbjct: 1488 LHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSY 1547

Query: 293  --SPDGVDQQLLDDFH--RVTKGGSTEDASQYYCDKNDNGDSYLV----LIRITPDEDGK 344
                +      +D +H   +++    E+ +    D  ++ + + +    LI +   E G 
Sbjct: 1548 QPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGS 1607

Query: 345  FGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIK 404
             GF +  G  +    V   I   + +D    +L  GD+++ +N  D++  TH   V  ++
Sbjct: 1608 LGFTVTKGNQRIGCYVHDVIQDPAKSDG---RLKPGDRLIKVNDTDVTNMTHTDAVNLLR 1664

Query: 405  ASRESHSRELALVIRR 420
            A+    S+ + LVI R
Sbjct: 1665 AA----SKTVRLVIGR 1676



 Score = 31.2 bits (69), Expect = 3.6
 Identities = 16/62 (25%), Positives = 34/62 (54%), Gaps = 4/62 (6%)

Query: 342  DGKFGFNLKGGVDQKMP---LVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQ 398
            D   G ++ GGV+  +    + V  + P+  A++   ++++GD+++ +NG  +   TH Q
Sbjct: 1184 DNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESD-GRIHKGDRVLAVNGVSLEGATHKQ 1242

Query: 399  VV 400
             V
Sbjct: 1243 AV 1244


>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
            isoform 1 [Homo sapiens]
          Length = 2485

 Score =  190 bits (482), Expect = 5e-48
 Identities = 110/299 (36%), Positives = 156/299 (52%), Gaps = 5/299 (1%)

Query: 429  FKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITF 488
            F + DEL  L    + P     G  L+  +  L+  L+ G    + E L   KP      
Sbjct: 2172 FLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLI 2231

Query: 489  AKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHT 548
             +  +N  KNRYK++LPYD TRV L     YINAS++ + +     V  YIA QGPLP T
Sbjct: 2232 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFV--YIACQGPLPTT 2289

Query: 549  CAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD--PPDVMNHGGFHIQCQSEDCTIA 606
               FWQ++W+QK ++I M+T   E  + KC +YWP+      M      +          
Sbjct: 2290 VGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKG 2349

Query: 607  YVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHC 666
            +V R M + + QT E   ++HL + AWPDH  P    D L F++Y+R +   S P++ HC
Sbjct: 2350 FVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH-RSGPIITHC 2408

Query: 667  SAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 725
            SAGIGR+G L+ ++  + L  ++L     D+VR MR QR  MVQT  QY F  + IL V
Sbjct: 2409 SAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2467



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 99/492 (20%), Positives = 184/492 (37%), Gaps = 93/492 (18%)

Query: 2    DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFL------T 55
            DI E R+ C   ++++LAS A+Q+ +GDY   +H   Y    H++P +  + L       
Sbjct: 686  DILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKE 745

Query: 56   KVESLHEQHSGLKQSEAESCYINIARTLDFYGVELH--SGRDLHNLDLMIGIASAGVAVY 113
            ++  LH  + G  + E E  ++ + + L  YGV  H           +++G+ S GV V+
Sbjct: 746  ELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVF 805

Query: 114  RKY----ICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKS 169
              +         +PW    KISF +KK  +   Q  ++  +H   F   N + C+ L   
Sbjct: 806  EVHNGVRTLVLRFPWRETKKISFSKKKITL---QNTSDGIKH--GFQTDNSKICQYLLHL 860

Query: 170  CVEHHTF-------------------------FQAKKLLPQEKNVLSQYWTMGSRNTKKR 204
            C   H F                          QA+ +            ++ S    K 
Sbjct: 861  CSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTLNKL 920

Query: 205  SPR---LRHEIRK-----------PRHSSADNLANEMTYITETEDVFYTY----KGSLAP 246
            + R   ++ EI K           P  +S+    ++ ++  +  ++  +Y    + SL P
Sbjct: 921  AVRPLSVQAEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYP 980

Query: 247  QDSDSEVSQNRSP-----------HQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPD 295
               +  V+    P           HQ S S+           +S SV+  + +P     +
Sbjct: 981  HRKNVIVNMEPPPQTVAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHE 1040

Query: 296  GVDQQLLDDFHR----VTKGGSTEDASQYYCDKND----------NGDSYLVLIRITPDE 341
                 + D        +T   S   +SQ    +ND          + +  + L+ +  D 
Sbjct: 1041 SDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDA 1100

Query: 342  DGKFGFNLKGGVDQ---KMPLVVSRINPESPADT--CIPKLNEGDQIVLINGRDISEHTH 396
                GF + GG       + + +S + P  PAD   C   L  GD+++ +N   +   +H
Sbjct: 1101 KYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGC---LKPGDRLISVNSVSLEGVSH 1157

Query: 397  DQVVMFIKASRE 408
               +  ++ + E
Sbjct: 1158 HAAIEILQNAPE 1169



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 56/256 (21%), Positives = 103/256 (40%), Gaps = 34/256 (13%)

Query: 186  EKNVLSQYWTMGSRNTKK-RSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSL 244
            E++  S    M  ++ K+ +SP  R        S  D+L      +T   ++  +   S 
Sbjct: 1625 EQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDL------VTAPANISNSTWSSA 1678

Query: 245  APQDSDSEVSQNRSPHQESLSENNP--AQSYLTQK---------SSSSVSPSSNAPGSC- 292
              Q   + VSQ +S H+   S+ +      Y  QK         S+ S  P   APG   
Sbjct: 1679 LHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSY 1738

Query: 293  --SPDGVDQQLLDDFH--RVTKGGSTEDASQYYCDKNDNGDSYLV----LIRITPDEDGK 344
                +      +D +H   +++    E+ +    D  ++ + + +    LI +   E G 
Sbjct: 1739 QPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGS 1798

Query: 345  FGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIK 404
             GF +  G  +    V   I   + +D    +L  GD+++ +N  D++  TH   V  ++
Sbjct: 1799 LGFTVTKGNQRIGCYVHDVIQDPAKSDG---RLKPGDRLIKVNDTDVTNMTHTDAVNLLR 1855

Query: 405  ASRESHSRELALVIRR 420
            A+    S+ + LVI R
Sbjct: 1856 AA----SKTVRLVIGR 1867



 Score = 31.2 bits (69), Expect = 3.6
 Identities = 16/62 (25%), Positives = 34/62 (54%), Gaps = 4/62 (6%)

Query: 342  DGKFGFNLKGGVDQKMP---LVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQ 398
            D   G ++ GGV+  +    + V  + P+  A++   ++++GD+++ +NG  +   TH Q
Sbjct: 1375 DNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESD-GRIHKGDRVLAVNGVSLEGATHKQ 1433

Query: 399  VV 400
             V
Sbjct: 1434 AV 1435


>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
            2 [Homo sapiens]
          Length = 2466

 Score =  190 bits (482), Expect = 5e-48
 Identities = 110/299 (36%), Positives = 156/299 (52%), Gaps = 5/299 (1%)

Query: 429  FKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITF 488
            F + DEL  L    + P     G  L+  +  L+  L+ G    + E L   KP      
Sbjct: 2153 FLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLI 2212

Query: 489  AKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHT 548
             +  +N  KNRYK++LPYD TRV L     YINAS++ + +     V  YIA QGPLP T
Sbjct: 2213 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFV--YIACQGPLPTT 2270

Query: 549  CAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD--PPDVMNHGGFHIQCQSEDCTIA 606
               FWQ++W+QK ++I M+T   E  + KC +YWP+      M      +          
Sbjct: 2271 VGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKG 2330

Query: 607  YVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHC 666
            +V R M + + QT E   ++HL + AWPDH  P    D L F++Y+R +   S P++ HC
Sbjct: 2331 FVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH-RSGPIITHC 2389

Query: 667  SAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 725
            SAGIGR+G L+ ++  + L  ++L     D+VR MR QR  MVQT  QY F  + IL V
Sbjct: 2390 SAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2448



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 50/187 (26%), Positives = 85/187 (45%), Gaps = 17/187 (9%)

Query: 2   DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFL------T 55
           DI E R+ C   ++++LAS A+Q+ +GDY   +H   Y    H++P +  + L       
Sbjct: 686 DILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKE 745

Query: 56  KVESLHEQHSGLKQSEAESCYINIARTLDFYGVELH--SGRDLHNLDLMIGIASAGVAVY 113
           ++  LH  + G  + E E  ++ + + L  YGV  H           +++G+ S GV V+
Sbjct: 746 ELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVF 805

Query: 114 RKY----ICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKS 169
             +         +PW    KISF +KK  +   Q  ++  +H   F   N + C+ L   
Sbjct: 806 EVHNGVRTLVLRFPWRETKKISFSKKKITL---QNTSDGIKH--GFQTDNSKICQYLLHL 860

Query: 170 CVEHHTF 176
           C   H F
Sbjct: 861 CSYQHKF 867



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 56/256 (21%), Positives = 103/256 (40%), Gaps = 34/256 (13%)

Query: 186  EKNVLSQYWTMGSRNTKK-RSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSL 244
            E++  S    M  ++ K+ +SP  R        S  D+L      +T   ++  +   S 
Sbjct: 1606 EQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDL------VTAPANISNSTWSSA 1659

Query: 245  APQDSDSEVSQNRSPHQESLSENNP--AQSYLTQK---------SSSSVSPSSNAPGSC- 292
              Q   + VSQ +S H+   S+ +      Y  QK         S+ S  P   APG   
Sbjct: 1660 LHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSY 1719

Query: 293  --SPDGVDQQLLDDFH--RVTKGGSTEDASQYYCDKNDNGDSYLV----LIRITPDEDGK 344
                +      +D +H   +++    E+ +    D  ++ + + +    LI +   E G 
Sbjct: 1720 QPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGS 1779

Query: 345  FGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIK 404
             GF +  G  +    V   I   + +D    +L  GD+++ +N  D++  TH   V  ++
Sbjct: 1780 LGFTVTKGNQRIGCYVHDVIQDPAKSDG---RLKPGDRLIKVNDTDVTNMTHTDAVNLLR 1836

Query: 405  ASRESHSRELALVIRR 420
            A+    S+ + LVI R
Sbjct: 1837 AA----SKTVRLVIGR 1848



 Score = 31.2 bits (69), Expect = 3.6
 Identities = 16/62 (25%), Positives = 34/62 (54%), Gaps = 4/62 (6%)

Query: 342  DGKFGFNLKGGVDQKMP---LVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQ 398
            D   G ++ GGV+  +    + V  + P+  A++   ++++GD+++ +NG  +   TH Q
Sbjct: 1356 DNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESD-GRIHKGDRVLAVNGVSLEGATHKQ 1414

Query: 399  VV 400
             V
Sbjct: 1415 AV 1416


>gi|109138573 protein tyrosine phosphatase, non-receptor type 20A
           isoform 8 [Homo sapiens]
          Length = 339

 Score =  185 bits (470), Expect = 1e-46
 Identities = 96/237 (40%), Positives = 136/237 (57%), Gaps = 8/237 (3%)

Query: 492 PQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQ 551
           P N +KNRY+D+LPYD+TRV L  ++DYINASY+ +          YIATQGPL  T   
Sbjct: 100 PSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVNCGEEYF--YIATQGPLLSTIDD 157

Query: 552 FWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYV 608
           FWQ+V +   ++I M+T   E G  KC+ YWP     P  + H  F +  ++      ++
Sbjct: 158 FWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKH--FRVFLENYQILQYFI 215

Query: 609 SREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSA 668
            R   V    TG  H+V  LQ+  WPDHG P  +  F++++ Y R   +   P++VHCSA
Sbjct: 216 IRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTG-PMVVHCSA 274

Query: 669 GIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 725
           GIGRTGV + ++   C   +N     +DIV +MR+QR+ MVQT  QY F  + +L V
Sbjct: 275 GIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV 331


>gi|109138561 protein tyrosine phosphatase, non-receptor type 20A
           isoform 3 [Homo sapiens]
          Length = 411

 Score =  185 bits (470), Expect = 1e-46
 Identities = 96/237 (40%), Positives = 136/237 (57%), Gaps = 8/237 (3%)

Query: 492 PQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQ 551
           P N +KNRY+D+LPYD+TRV L  ++DYINASY+ +          YIATQGPL  T   
Sbjct: 172 PSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVNCGEEYF--YIATQGPLLSTIDD 229

Query: 552 FWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYV 608
           FWQ+V +   ++I M+T   E G  KC+ YWP     P  + H  F +  ++      ++
Sbjct: 230 FWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKH--FRVFLENYQILQYFI 287

Query: 609 SREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSA 668
            R   V    TG  H+V  LQ+  WPDHG P  +  F++++ Y R   +   P++VHCSA
Sbjct: 288 IRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTG-PMVVHCSA 346

Query: 669 GIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 725
           GIGRTGV + ++   C   +N     +DIV +MR+QR+ MVQT  QY F  + +L V
Sbjct: 347 GIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV 403


>gi|109138557 protein tyrosine phosphatase, non-receptor type 20A
           isoform 1 [Homo sapiens]
          Length = 420

 Score =  185 bits (470), Expect = 1e-46
 Identities = 96/237 (40%), Positives = 136/237 (57%), Gaps = 8/237 (3%)

Query: 492 PQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQ 551
           P N +KNRY+D+LPYD+TRV L  ++DYINASY+ +          YIATQGPL  T   
Sbjct: 181 PSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVNCGEEYF--YIATQGPLLSTIDD 238

Query: 552 FWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYV 608
           FWQ+V +   ++I M+T   E G  KC+ YWP     P  + H  F +  ++      ++
Sbjct: 239 FWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKH--FRVFLENYQILQYFI 296

Query: 609 SREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSA 668
            R   V    TG  H+V  LQ+  WPDHG P  +  F++++ Y R   +   P++VHCSA
Sbjct: 297 IRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTG-PMVVHCSA 355

Query: 669 GIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 725
           GIGRTGV + ++   C   +N     +DIV +MR+QR+ MVQT  QY F  + +L V
Sbjct: 356 GIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV 412


>gi|108802617 protein tyrosine phosphatase, non-receptor type 20
           isoform 8 [Homo sapiens]
          Length = 339

 Score =  185 bits (470), Expect = 1e-46
 Identities = 96/237 (40%), Positives = 136/237 (57%), Gaps = 8/237 (3%)

Query: 492 PQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQ 551
           P N +KNRY+D+LPYD+TRV L  ++DYINASY+ +          YIATQGPL  T   
Sbjct: 100 PSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVNCGEEYF--YIATQGPLLSTIDD 157

Query: 552 FWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYV 608
           FWQ+V +   ++I M+T   E G  KC+ YWP     P  + H  F +  ++      ++
Sbjct: 158 FWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKH--FRVFLENYQILQYFI 215

Query: 609 SREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSA 668
            R   V    TG  H+V  LQ+  WPDHG P  +  F++++ Y R   +   P++VHCSA
Sbjct: 216 IRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTG-PMVVHCSA 274

Query: 669 GIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 725
           GIGRTGV + ++   C   +N     +DIV +MR+QR+ MVQT  QY F  + +L V
Sbjct: 275 GIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV 331


>gi|108802607 protein tyrosine phosphatase, non-receptor type 20
           isoform 3 [Homo sapiens]
          Length = 411

 Score =  185 bits (470), Expect = 1e-46
 Identities = 96/237 (40%), Positives = 136/237 (57%), Gaps = 8/237 (3%)

Query: 492 PQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQ 551
           P N +KNRY+D+LPYD+TRV L  ++DYINASY+ +          YIATQGPL  T   
Sbjct: 172 PSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVNCGEEYF--YIATQGPLLSTIDD 229

Query: 552 FWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYV 608
           FWQ+V +   ++I M+T   E G  KC+ YWP     P  + H  F +  ++      ++
Sbjct: 230 FWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKH--FRVFLENYQILQYFI 287

Query: 609 SREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSA 668
            R   V    TG  H+V  LQ+  WPDHG P  +  F++++ Y R   +   P++VHCSA
Sbjct: 288 IRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTG-PMVVHCSA 346

Query: 669 GIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 725
           GIGRTGV + ++   C   +N     +DIV +MR+QR+ MVQT  QY F  + +L V
Sbjct: 347 GIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV 403


>gi|108802604 protein tyrosine phosphatase, non-receptor type 20
           isoform 1 [Homo sapiens]
          Length = 420

 Score =  185 bits (470), Expect = 1e-46
 Identities = 96/237 (40%), Positives = 136/237 (57%), Gaps = 8/237 (3%)

Query: 492 PQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQ 551
           P N +KNRY+D+LPYD+TRV L  ++DYINASY+ +          YIATQGPL  T   
Sbjct: 181 PSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVNCGEEYF--YIATQGPLLSTIDD 238

Query: 552 FWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP---DPPDVMNHGGFHIQCQSEDCTIAYV 608
           FWQ+V +   ++I M+T   E G  KC+ YWP     P  + H  F +  ++      ++
Sbjct: 239 FWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKH--FRVFLENYQILQYFI 296

Query: 609 SREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSA 668
            R   V    TG  H+V  LQ+  WPDHG P  +  F++++ Y R   +   P++VHCSA
Sbjct: 297 IRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTG-PMVVHCSA 355

Query: 669 GIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 725
           GIGRTGV + ++   C   +N     +DIV +MR+QR+ MVQT  QY F  + +L V
Sbjct: 356 GIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV 412


>gi|148728162 protein tyrosine phosphatase, receptor type, J isoform 1
            precursor [Homo sapiens]
          Length = 1337

 Score =  182 bits (461), Expect = 1e-45
 Identities = 95/244 (38%), Positives = 136/244 (55%), Gaps = 12/244 (4%)

Query: 489  AKLPQNLDKNRYKDVLPYDTTRVLLQ----GNEDYINASYVNMEIPAANLVNKYIATQGP 544
            A+L +N  KNRY +VLPYD +RV L       +DYINA+Y+    P  +    +IATQGP
Sbjct: 1060 AELAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYM----PGYHSKKDFIATQGP 1115

Query: 545  LPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCT 604
            LP+T   FW++VW++ +  I+MLT   E+GRTKC +YWP      ++G   +   SE   
Sbjct: 1116 LPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPS-KQAQDYGDITVAMTSEIVL 1174

Query: 605  IAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDS---EP 661
              +  R+  V N QT E H +    + +WPDHGVPD +   + F   VR     S    P
Sbjct: 1175 PEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESP 1234

Query: 662  VLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEA 721
            +LVHCSAG+GRTG  + ++  +   E    +    IV  +R  R +MVQT  QY F+ + 
Sbjct: 1235 ILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQC 1294

Query: 722  ILRV 725
            +L +
Sbjct: 1295 VLDI 1298


>gi|4506289 protein tyrosine phosphatase, non-receptor type 1 [Homo
           sapiens]
          Length = 435

 Score =  180 bits (457), Expect = 4e-45
 Identities = 99/268 (36%), Positives = 147/268 (54%), Gaps = 14/268 (5%)

Query: 466 ESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL-QGNEDYINASY 524
           +SG+    ++ +  +        AKLP+N ++NRY+DV P+D +R+ L Q + DYINAS 
Sbjct: 12  KSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASL 71

Query: 525 VNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD 584
           + ME         YI TQGPLP+TC  FW++VW+QK   +VML  + E+G  KC QYWP 
Sbjct: 72  IKME----EAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQ 127

Query: 585 PPD---VMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDD 641
             +   +       +   SED    Y  R++ + N  T E   + H  Y  WPD GVP+ 
Sbjct: 128 KEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPES 187

Query: 642 SSDFLEFVNYVR---SLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIV 698
            + FL F+  VR   SL  +  PV+VHCSAGIGR+G     +T + L ++      +DI 
Sbjct: 188 PASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIK 247

Query: 699 R---KMRDQRAMMVQTSSQYKFVCEAIL 723
           +   +MR  R  ++QT+ Q +F   A++
Sbjct: 248 KVLLEMRKFRMGLIQTADQLRFSYLAVI 275


>gi|241896926 protein tyrosine phosphatase, receptor type, H isoform
           2 precursor [Homo sapiens]
          Length = 937

 Score =  179 bits (455), Expect = 6e-45
 Identities = 95/248 (38%), Positives = 135/248 (54%), Gaps = 12/248 (4%)

Query: 489 AKLPQNLDKNRYKDVLPYDTTRVLL-----QGNEDYINASYVNMEIPAANLVNKYIATQG 543
           A   +N  KNRY++VLPYD +RV L     +   DYINAS++    P      ++IATQG
Sbjct: 661 ASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFM----PGLWSPQEFIATQG 716

Query: 544 PLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDC 603
           PLP T   FW++VW+Q+   +VMLT   E GR KC  YWP       HG   +    E+ 
Sbjct: 717 PLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEV 776

Query: 604 TIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVR---SLRVDSE 660
              +  RE+L+   +  +  +V    Y AWPDHGVP      L F   +R      ++  
Sbjct: 777 MENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGG 836

Query: 661 PVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCE 720
           P +VHCSAG+GRTG L+ ++  +   +    + P   VRKMR+ R +MVQT +QY F+ +
Sbjct: 837 PPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQ 896

Query: 721 AILRVYEE 728
            ILR  ++
Sbjct: 897 CILRFLQQ 904


>gi|241896924 protein tyrosine phosphatase, receptor type, H isoform 1
            precursor [Homo sapiens]
          Length = 1115

 Score =  179 bits (455), Expect = 6e-45
 Identities = 95/248 (38%), Positives = 135/248 (54%), Gaps = 12/248 (4%)

Query: 489  AKLPQNLDKNRYKDVLPYDTTRVLL-----QGNEDYINASYVNMEIPAANLVNKYIATQG 543
            A   +N  KNRY++VLPYD +RV L     +   DYINAS++    P      ++IATQG
Sbjct: 839  ASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFM----PGLWSPQEFIATQG 894

Query: 544  PLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDC 603
            PLP T   FW++VW+Q+   +VMLT   E GR KC  YWP       HG   +    E+ 
Sbjct: 895  PLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEV 954

Query: 604  TIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVR---SLRVDSE 660
               +  RE+L+   +  +  +V    Y AWPDHGVP      L F   +R      ++  
Sbjct: 955  MENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGG 1014

Query: 661  PVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCE 720
            P +VHCSAG+GRTG L+ ++  +   +    + P   VRKMR+ R +MVQT +QY F+ +
Sbjct: 1015 PPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQ 1074

Query: 721  AILRVYEE 728
             ILR  ++
Sbjct: 1075 CILRFLQQ 1082


>gi|157952215 protein tyrosine phosphatase, receptor type, B isoform a
            [Homo sapiens]
          Length = 2215

 Score =  177 bits (448), Expect = 4e-44
 Identities = 102/286 (35%), Positives = 149/286 (52%), Gaps = 16/286 (5%)

Query: 447  CPEGGDTLEGSMAQLKKGLESGTVLI-QFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLP 505
            CP   +  EG   +L+   +S  +L  ++E+L       +   A LP+N  KNRY ++LP
Sbjct: 1899 CPIKINQFEGHFMKLQA--DSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILP 1956

Query: 506  YDTTRVLLQGNED-----YINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQK 560
            YD TRV L   +D     YINASY    IP  N   +YI TQGPLP T   FW++VW+Q 
Sbjct: 1957 YDATRVKLSNVDDDPCSDYINASY----IPGNNFRREYIVTQGPLPGTKDDFWKMVWEQN 2012

Query: 561  LSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTG 620
            +  IVM+T   E+GR KC  YWP   D + +G   +Q  SE     +  RE  +   +  
Sbjct: 2013 VHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQL 2072

Query: 621  EEH-TVTHLQYVAWPDHGVPDDSSDFLEFVNYVR---SLRVDSEPVLVHCSAGIGRTGVL 676
            + H  + H  Y  WPDHGVP+ +   ++FV  VR   +    + P +VHCSAG+GRTG  
Sbjct: 2073 DAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTF 2132

Query: 677  VTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAI 722
            + ++  +   +    +     V  +R  R  MVQT  QY ++ + +
Sbjct: 2133 IALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 2178


>gi|157952213 protein tyrosine phosphatase, receptor type, B isoform b
            precursor [Homo sapiens]
          Length = 1997

 Score =  177 bits (448), Expect = 4e-44
 Identities = 102/286 (35%), Positives = 149/286 (52%), Gaps = 16/286 (5%)

Query: 447  CPEGGDTLEGSMAQLKKGLESGTVLI-QFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLP 505
            CP   +  EG   +L+   +S  +L  ++E+L       +   A LP+N  KNRY ++LP
Sbjct: 1681 CPIKINQFEGHFMKLQA--DSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILP 1738

Query: 506  YDTTRVLLQGNED-----YINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQK 560
            YD TRV L   +D     YINASY    IP  N   +YI TQGPLP T   FW++VW+Q 
Sbjct: 1739 YDATRVKLSNVDDDPCSDYINASY----IPGNNFRREYIVTQGPLPGTKDDFWKMVWEQN 1794

Query: 561  LSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTG 620
            +  IVM+T   E+GR KC  YWP   D + +G   +Q  SE     +  RE  +   +  
Sbjct: 1795 VHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQL 1854

Query: 621  EEH-TVTHLQYVAWPDHGVPDDSSDFLEFVNYVR---SLRVDSEPVLVHCSAGIGRTGVL 676
            + H  + H  Y  WPDHGVP+ +   ++FV  VR   +    + P +VHCSAG+GRTG  
Sbjct: 1855 DAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTF 1914

Query: 677  VTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAI 722
            + ++  +   +    +     V  +R  R  MVQT  QY ++ + +
Sbjct: 1915 IALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 1960


>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
            isoform 4 precursor [Homo sapiens]
          Length = 1505

 Score =  173 bits (439), Expect = 5e-43
 Identities = 105/277 (37%), Positives = 151/277 (54%), Gaps = 19/277 (6%)

Query: 458  MAQLKKGLESGTVLIQFEQLYRKKPGLAITF--AKLPQNLDKNRYKDVLPYDTTRVLLQG 515
            MA+  + L++   L   ++     PG   T+  + L  N  KNRY +V+ YD +RV+LQ 
Sbjct: 935  MAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQP 994

Query: 516  NE-----DYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTL 570
             E     DYINA+YV+         N YIATQGPLP T   FW++VW+Q+ + IVM+T L
Sbjct: 995  IEGIMGSDYINANYVD----GYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRL 1050

Query: 571  TERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQY 630
             E+ R KC QYWP+      +G   +          +  R   +    + E+  V   Q+
Sbjct: 1051 EEKSRIKCDQYWPN-RGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1109

Query: 631  VAWPDHGVPDDSSDFLEFVNYVRSLR-VDSEPVLVHCSAGIGRTGVLVTMETAMCLTERN 689
             AWPDHGVP+  + FL F+  V++    D+ P++VHCSAG+GRTG  + ++    + ER 
Sbjct: 1110 TAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVID---AMLERI 1166

Query: 690  LPIYPLDI---VRKMRDQRAMMVQTSSQYKFVCEAIL 723
             P   +D+   V  MR QR  MVQT  QY F+ EA+L
Sbjct: 1167 KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALL 1203



 Score =  171 bits (434), Expect = 2e-42
 Identities = 97/275 (35%), Positives = 145/275 (52%), Gaps = 14/275 (5%)

Query: 458  MAQLKKGLESGTVLIQFEQLYRKKPGLA-ITFAKLPQNLDKNRYKDVLPYDTTRVLLQG- 515
            +AQ++ G     + ++F++L   K   +    A LP N  KNR  +++PY++TRV LQ  
Sbjct: 1225 LAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1284

Query: 516  ----NEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLT 571
                  DYINAS+++           YIATQGPL  T   FW+++W+   +++VMLT L 
Sbjct: 1285 RGVEGSDYINASFID----GYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLR 1340

Query: 572  ERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYV 631
            E GR KCHQYWP       +  F +   +E     Y+ RE  VT+ + G+  TV   Q+ 
Sbjct: 1341 EMGREKCHQYWPAERSA-RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT 1399

Query: 632  AWPDHGVPDDSSDFLEFVNYVRSLRV---DSEPVLVHCSAGIGRTGVLVTMETAMCLTER 688
             WP+ GVP     F++F+  V   +       P+ VHCSAG+GRTGV +T+   +     
Sbjct: 1400 DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1459

Query: 689  NLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL 723
               +     V+ +R QR  MVQT  +Y+F  +A L
Sbjct: 1460 EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAAL 1494


>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
            isoform 2 precursor [Homo sapiens]
          Length = 1910

 Score =  173 bits (439), Expect = 5e-43
 Identities = 105/277 (37%), Positives = 151/277 (54%), Gaps = 19/277 (6%)

Query: 458  MAQLKKGLESGTVLIQFEQLYRKKPGLAITF--AKLPQNLDKNRYKDVLPYDTTRVLLQG 515
            MA+  + L++   L   ++     PG   T+  + L  N  KNRY +V+ YD +RV+LQ 
Sbjct: 1340 MAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQP 1399

Query: 516  NE-----DYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTL 570
             E     DYINA+YV+         N YIATQGPLP T   FW++VW+Q+ + IVM+T L
Sbjct: 1400 IEGIMGSDYINANYVD----GYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRL 1455

Query: 571  TERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQY 630
             E+ R KC QYWP+      +G   +          +  R   +    + E+  V   Q+
Sbjct: 1456 EEKSRIKCDQYWPN-RGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1514

Query: 631  VAWPDHGVPDDSSDFLEFVNYVRSLR-VDSEPVLVHCSAGIGRTGVLVTMETAMCLTERN 689
             AWPDHGVP+  + FL F+  V++    D+ P++VHCSAG+GRTG  + ++    + ER 
Sbjct: 1515 TAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVID---AMLERI 1571

Query: 690  LPIYPLDI---VRKMRDQRAMMVQTSSQYKFVCEAIL 723
             P   +D+   V  MR QR  MVQT  QY F+ EA+L
Sbjct: 1572 KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALL 1608



 Score =  171 bits (434), Expect = 2e-42
 Identities = 97/275 (35%), Positives = 145/275 (52%), Gaps = 14/275 (5%)

Query: 458  MAQLKKGLESGTVLIQFEQLYRKKPGLA-ITFAKLPQNLDKNRYKDVLPYDTTRVLLQG- 515
            +AQ++ G     + ++F++L   K   +    A LP N  KNR  +++PY++TRV LQ  
Sbjct: 1630 LAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1689

Query: 516  ----NEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLT 571
                  DYINAS+++           YIATQGPL  T   FW+++W+   +++VMLT L 
Sbjct: 1690 RGVEGSDYINASFID----GYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLR 1745

Query: 572  ERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYV 631
            E GR KCHQYWP       +  F +   +E     Y+ RE  VT+ + G+  TV   Q+ 
Sbjct: 1746 EMGREKCHQYWPAERSA-RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT 1804

Query: 632  AWPDHGVPDDSSDFLEFVNYVRSLRV---DSEPVLVHCSAGIGRTGVLVTMETAMCLTER 688
             WP+ GVP     F++F+  V   +       P+ VHCSAG+GRTGV +T+   +     
Sbjct: 1805 DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1864

Query: 689  NLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL 723
               +     V+ +R QR  MVQT  +Y+F  +A L
Sbjct: 1865 EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAAL 1899


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,577,356
Number of Sequences: 37866
Number of extensions: 1302322
Number of successful extensions: 4837
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 195
Number of HSP's successfully gapped in prelim test: 119
Number of HSP's that attempted gapping in prelim test: 3911
Number of HSP's gapped (non-prelim): 520
length of query: 737
length of database: 18,247,518
effective HSP length: 110
effective length of query: 627
effective length of database: 14,082,258
effective search space: 8829575766
effective search space used: 8829575766
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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