Search of human proteins with 223718037

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens]
         (853 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens]           1729   0.0  
gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens]           1725   0.0  
gi|170650674 phosphodiesterase 6A [Homo sapiens]                     1263   0.0  
gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens]           1165   0.0  
gi|157364939 phosphodiesterase 6C [Homo sapiens]                     1141   0.0  
gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens]           429   e-120
gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens]             406   e-113
gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens]             406   e-113
gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens]             406   e-113
gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens]           380   e-105
gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens]           347   4e-95
gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens]           326   5e-89
gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens]            283   4e-76
gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens]            283   4e-76
gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens]              283   4e-76
gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens]           232   1e-60
gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens]             231   3e-60
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]            142   2e-33
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]             142   2e-33
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]            141   2e-33
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]            141   2e-33
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]            141   2e-33
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]              141   2e-33
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]      137   4e-32
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]      137   4e-32
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]      137   4e-32
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]             134   5e-31
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]             134   5e-31
gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]             134   5e-31
gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens]             134   5e-31

>gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens]
          Length = 853

 Score = 1729 bits (4479), Expect = 0.0
 Identities = 853/853 (100%), Positives = 853/853 (100%)

Query: 1   MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALL 60
           MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALL
Sbjct: 1   MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALL 60

Query: 61  ELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLE 120
           ELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLE
Sbjct: 61  ELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLE 120

Query: 121 DCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPI 180
           DCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPI
Sbjct: 121 DCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPI 180

Query: 181 MNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLL 240
           MNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLL
Sbjct: 181 MNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLL 240

Query: 241 WSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPY 300
           WSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPY
Sbjct: 241 WSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPY 300

Query: 301 SGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNA 360
           SGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNA
Sbjct: 301 SGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNA 360

Query: 361 SADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMES 420
           SADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMES
Sbjct: 361 SADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMES 420

Query: 421 LTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADC 480
           LTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADC
Sbjct: 421 LTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADC 480

Query: 481 DEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVL 540
           DEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVL
Sbjct: 481 DEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVL 540

Query: 541 VRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDID 600
           VRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDID
Sbjct: 541 VRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDID 600

Query: 601 HRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLM 660
           HRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLM
Sbjct: 601 HRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLM 660

Query: 661 DIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLS 720
           DIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLS
Sbjct: 661 DIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLS 720

Query: 721 AITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCT 780
           AITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCT
Sbjct: 721 AITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCT 780

Query: 781 FVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKGTEICN 840
           FVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKGTEICN
Sbjct: 781 FVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKGTEICN 840

Query: 841 GGPAPKSSTCCIL 853
           GGPAPKSSTCCIL
Sbjct: 841 GGPAPKSSTCCIL 853


>gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens]
          Length = 854

 Score = 1725 bits (4467), Expect = 0.0
 Identities = 853/854 (99%), Positives = 853/854 (99%), Gaps = 1/854 (0%)

Query: 1   MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALL 60
           MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALL
Sbjct: 1   MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALL 60

Query: 61  ELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLE 120
           ELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLE
Sbjct: 61  ELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLE 120

Query: 121 DCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPI 180
           DCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPI
Sbjct: 121 DCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPI 180

Query: 181 MNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLL 240
           MNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLL
Sbjct: 181 MNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLL 240

Query: 241 WSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPY 300
           WSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPY
Sbjct: 241 WSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPY 300

Query: 301 SGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNA 360
           SGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNA
Sbjct: 301 SGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNA 360

Query: 361 SADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMES 420
           SADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMES
Sbjct: 361 SADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMES 420

Query: 421 LTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADC 480
           LTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADC
Sbjct: 421 LTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADC 480

Query: 481 DEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVL 540
           DEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVL
Sbjct: 481 DEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVL 540

Query: 541 VRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDID 600
           VRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDID
Sbjct: 541 VRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDID 600

Query: 601 HRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLM 660
           HRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLM
Sbjct: 601 HRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLM 660

Query: 661 DIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLS 720
           DIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLS
Sbjct: 661 DIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLS 720

Query: 721 AITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCT 780
           AITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCT
Sbjct: 721 AITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCT 780

Query: 781 FVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKK-GTEIC 839
           FVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKK GTEIC
Sbjct: 781 FVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKVGTEIC 840

Query: 840 NGGPAPKSSTCCIL 853
           NGGPAPKSSTCCIL
Sbjct: 841 NGGPAPKSSTCCIL 854


>gi|170650674 phosphodiesterase 6A [Homo sapiens]
          Length = 860

 Score = 1263 bits (3269), Expect = 0.0
 Identities = 619/860 (71%), Positives = 712/860 (82%), Gaps = 14/860 (1%)

Query: 3   LSEEQARSFLDQNPDFARQYFG----KKLSPENVAAACEDGCPPDCDSLRDLCQVEESTA 58
           ++ E+   FLD N  FA+QY+      KL  + + A        D  +      +EES  
Sbjct: 4   VTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGAK---EAAVDFSNYHSPSSMEESEI 60

Query: 59  LLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSV 118
           + +L++D QE++  E+ +F V+++LC LLQADR SLFMYR RNG+AELATRLF+V  D+V
Sbjct: 61  IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKDAV 120

Query: 119 LEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLAT 178
           LEDCLV PD EIVFPLD+G+VGHVA +KK+ NV +  E  HF  F D LT+YKTKN+LA+
Sbjct: 121 LEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILAS 180

Query: 179 PIMNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQV 238
           PIMNGKDVVA+IMAVNK++G  FT  DE++ LKYLNFA L +K+YHLSYLHNCETRRGQ+
Sbjct: 181 PIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQI 240

Query: 239 LLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQ 298
           LLWS +KVFEELTDIERQFHKA YTVRA+LNC+RYSVGLLDMTK+KEFFDVW VLMGE  
Sbjct: 241 LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVP 300

Query: 299 PYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIM 358
           PYSGPRTPDGREI FYKVIDYILHGKE+IKVIP P  DHWAL SGLP+YVA++G ICNIM
Sbjct: 301 PYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIM 360

Query: 359 NASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLM 418
           NA A++ F FQ+  LD+SGW+IKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDE DE LM
Sbjct: 361 NAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLM 420

Query: 419 ESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPA 478
           ESLTQFLGWSV+N DTY+ MNKLENRKDI QD+V YHVKCD +EIQ IL TR   GKEP 
Sbjct: 421 ESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPW 480

Query: 479 DCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQE 538
           +C+E+EL EIL+ ELP    ++I +FHFSDL  TEL+LVKCGIQMYYEL VV KF IPQE
Sbjct: 481 ECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQE 540

Query: 539 VLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHD 598
            LVRF++S+SKGYR+ITYHNWRHGFNV QTMF+LL+TGKLK Y+TDLEA AMVTA  CHD
Sbjct: 541 ALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD 600

Query: 599 IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIH 658
           IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGK LL +E+LNI+QNLNRRQHEH IH
Sbjct: 601 IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIH 660

Query: 659 LMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACD 718
           +MDIAIIATDLALYFKKR MFQKIVD+SK Y+ ++ W +Y+ LE TRKEIVMAMMMTACD
Sbjct: 661 MMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACD 720

Query: 719 LSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFV 778
           LSAITKPWEVQS+VALLVAAEFWEQGDLERTVL Q PIPMMDRNKA ELPKLQVGFIDFV
Sbjct: 721 LSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFV 780

Query: 779 CTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVA--AKKGT 836
           CTFVYKEFSRFHEEI PM D + NNRKEWKALADEY+AK+K  EEK+++++ A  A  G 
Sbjct: 781 CTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQSAKSAAAGN 840

Query: 837 EICNGGPAP----KSSTCCI 852
           +   G P+P     S +CCI
Sbjct: 841 Q-PGGNPSPGGATTSKSCCI 859


>gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens]
          Length = 575

 Score = 1165 bits (3013), Expect = 0.0
 Identities = 574/575 (99%), Positives = 574/575 (99%), Gaps = 1/575 (0%)

Query: 280 MTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWA 339
           MTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWA
Sbjct: 1   MTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWA 60

Query: 340 LASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVA 399
           LASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVA
Sbjct: 61  LASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVA 120

Query: 400 TFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 459
           TFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD
Sbjct: 121 TFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 180

Query: 460 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 519
           RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC
Sbjct: 181 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 240

Query: 520 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLK 579
           GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLK
Sbjct: 241 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLK 300

Query: 580 SYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSE 639
           SYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSE
Sbjct: 301 SYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSE 360

Query: 640 ETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYL 699
           ETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYL
Sbjct: 361 ETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYL 420

Query: 700 SLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMM 759
           SLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMM
Sbjct: 421 SLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMM 480

Query: 760 DRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVK 819
           DRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVK
Sbjct: 481 DRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVK 540

Query: 820 ALEEKEEEERVAAKK-GTEICNGGPAPKSSTCCIL 853
           ALEEKEEEERVAAKK GTEICNGGPAPKSSTCCIL
Sbjct: 541 ALEEKEEEERVAAKKVGTEICNGGPAPKSSTCCIL 575


>gi|157364939 phosphodiesterase 6C [Homo sapiens]
          Length = 858

 Score = 1141 bits (2952), Expect = 0.0
 Identities = 551/855 (64%), Positives = 684/855 (80%), Gaps = 4/855 (0%)

Query: 3   LSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLR--DLCQVEESTALL 60
           +++     +L++NP FA++YF +KL  E +    ++   P   S+   +L QVEES   L
Sbjct: 4   INQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCL 63

Query: 61  ELVQDMQESINM-ERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVL 119
           EL+  +QE     E+ V + L+RL  LLQADRCS+F+ R RNG+ E+A+RL  V P S  
Sbjct: 64  ELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKF 123

Query: 120 EDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATP 179
           ED LV PD E+VFPLDIG+VG  A TKK  NV DV +  HFS F D+ T Y TKN+LATP
Sbjct: 124 EDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATP 183

Query: 180 IMNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVL 239
           I+ GK+V+AVIMAVNK+N   F+ +DE+VF KYLNF ++ L+++H SY++N E+RR Q+L
Sbjct: 184 IVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQIL 243

Query: 240 LWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQP 299
           +WSANKVFEELTD+ERQFHKA YTVR+YLNCERYS+GLLDMTKEKEF+D W + +GE +P
Sbjct: 244 MWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEP 303

Query: 300 YSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMN 359
           Y GP+TPDGRE+ FYK+IDYILHGKEEIKVIPTP ADHW L SGLP+YVAE+GFICN+MN
Sbjct: 304 YKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMN 363

Query: 360 ASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLME 419
           A ADE F FQ+G +D++GW+IKNVLS+PIVNKKE+IVGVATFYNRKDGKPFDE DE + E
Sbjct: 364 APADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITE 423

Query: 420 SLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPA- 478
           +LTQFLGWS++NTDTYDKMNKLENRKDIAQ+M++   K   +EI+ IL  + +L  +   
Sbjct: 424 TLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVID 483

Query: 479 DCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQE 538
           DC+E +L  ILKE+LP P + ++YEF FSD   TE  L+KCGI++++E+ VV KF++P E
Sbjct: 484 DCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVE 543

Query: 539 VLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHD 598
           VL R+++++ KGYR +TYHNWRHGFNV QTMFTLLMTG+LK YYTDLEAFAM+ A  CHD
Sbjct: 544 VLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHD 603

Query: 599 IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIH 658
           IDHRGTNNLYQMKS +PLA+LHGSSILERHHLE+ K LL +E+LNI+QNLN+RQ E VIH
Sbjct: 604 IDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIH 663

Query: 659 LMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACD 718
           L ++AIIATDLALYFKKR MFQKIVD  +  Q ++  ++Y++++ T+KEI+MAMMMTACD
Sbjct: 664 LFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACD 723

Query: 719 LSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFV 778
           LSAITKPWEVQS+VAL+VA EFWEQGDLERTVL QQPIPMMDRNK  ELPKLQVGFIDFV
Sbjct: 724 LSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFV 783

Query: 779 CTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKGTEI 838
           CTFVYKEFSRFH+EI PM   LQNNR EWK+LADEY+AK+K +EE+ +++   A+K  E 
Sbjct: 784 CTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAED 843

Query: 839 CNGGPAPKSSTCCIL 853
             GG   KS TC +L
Sbjct: 844 SGGGDDKKSKTCLML 858


>gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens]
          Length = 933

 Score =  429 bits (1102), Expect = e-120
 Identities = 258/763 (33%), Positives = 402/763 (52%), Gaps = 62/763 (8%)

Query: 55  ESTALLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYR-QRNGVAELATRLFSV 113
           E    LELV+D+   +++  + +K+L  +C ++ ADRCSLF+      G   L ++ F V
Sbjct: 201 ERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDV 260

Query: 114 QPDSVLEDCLVPPDS-EIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKT 172
              + L  C    +S E+  P   G++G+V +  + VN+ D  +   F+   D+LT YKT
Sbjct: 261 HAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKT 320

Query: 173 KNMLATPIMNGK-DVVAVIMAVNKL-NGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHN 230
           K++L  PI +   +++ V  A+NK+  G  FT +DE V   YL F  + +    L     
Sbjct: 321 KSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASR 380

Query: 231 CETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVW 290
            E  R + LL   N +FEE TD+E+   K  +  +  L CER SV LL+        D+ 
Sbjct: 381 KEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLE--------DIE 432

Query: 291 SVLMGESQPYS--GPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYV 348
           S ++  ++ +    P+     E  F          KE ++     S   W + + +   V
Sbjct: 433 SPVVKFTKSFELMSPKCSADAENSF----------KESME---KSSYSDWLINNSIAELV 479

Query: 349 AESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGK 408
           A +G   NI +A  D  F  +   +  SG+ I++VL +PI N   +I+GVA   NR DGK
Sbjct: 480 ASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK 537

Query: 409 PFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILP 468
           PFD+ D+ L E+   F G  + NT  YD++ K   ++ +A D++ YH  C + E+     
Sbjct: 538 PFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKA 597

Query: 469 TRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELG 528
               L  E A                      I + HF D       ++   ++M+ ELG
Sbjct: 598 ANIPLVSELA----------------------IDDIHFDDFSLDVDAMITAALRMFMELG 635

Query: 529 VVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAF 588
           +V+KF+I  E L R+L ++ K YR + YHNWRH FNV Q MF +L T   +   T++E  
Sbjct: 636 MVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEIL 695

Query: 589 AMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQN 647
           A++   LCHD+DHRGTNN +Q KS + LA+L+G S+ LE HH      +L  E  NI+ N
Sbjct: 696 AVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFAN 755

Query: 648 LNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKE 707
           L+ +++  ++ L+  +I+ATDL LYF++R  F ++V +           EY       ++
Sbjct: 756 LSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKG----------EYDWNIKNHRD 805

Query: 708 IVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAEL 767
           I  +M+MTACDL A+TKPWE+  +VA LV +EF+EQGD ER  L   P  + DRN+  EL
Sbjct: 806 IFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDEL 865

Query: 768 PKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKAL 810
           P+LQ+ +ID +C  +Y+   + + ++ PM D +  NR +W+ L
Sbjct: 866 PRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL 908


>gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens]
          Length = 875

 Score =  406 bits (1044), Expect = e-113
 Identities = 253/778 (32%), Positives = 418/778 (53%), Gaps = 79/778 (10%)

Query: 54  EESTALLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAE-LATRLFS 112
           ++ + LLELV+D+   +++  +  K+   +  L+ ADR SLF+  + +   + L +RLF 
Sbjct: 147 DQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFD 206

Query: 113 VQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKT 172
           V   S LE+     ++ I    + G+VGHVA   + +N++D  E P F++  D++T YKT
Sbjct: 207 VAEGSTLEEV---SNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKT 263

Query: 173 KNMLATPIMNGKD-VVAVIMAVNKL--NGPFFTSEDEDVFLKYLNFATLYL---KIYHLS 226
           +++L  PI N ++ VV V  A+NK   NG  FT +DE  F  YL F  + L   ++Y  S
Sbjct: 264 QSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETS 323

Query: 227 YLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEF 286
            L N   +R QVLL  A+ +FEE   +E    K   T+ +++  ++ ++ ++D      F
Sbjct: 324 LLEN---KRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSF 380

Query: 287 FDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPS 346
             V+ +   E +  S   T +              H   +I  +                
Sbjct: 381 SSVFHMECEELEKSSDTLTRE--------------HDANKINYM-------------YAQ 413

Query: 347 YVAESGFICNIMNASADEMFKFQ-EGALDDSGWLIKNVLSMPIVN-KKEEIVGVATFYNR 404
           YV  +    NI + S D+ F +  E   + +   I+++L  PI N KK +++GV    N+
Sbjct: 414 YVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNK 473

Query: 405 KDG-----KPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 459
            +      KPF+  DE  +E+   F G  + NT  Y+ + +   ++ +  +++ YH    
Sbjct: 474 MEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAA 533

Query: 460 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 519
            +E +                   EL  +    +P   T  I +F FSD E ++L+   C
Sbjct: 534 EEETR-------------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALC 574

Query: 520 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKL 578
            I+M+ +L +V+ FQ+  EVL R++ S+ K YR+ + YHNWRH FN AQ MF  L  GK+
Sbjct: 575 TIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKI 634

Query: 579 KSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLS 638
           ++  TDLE  A++ A L HD+DHRG NN Y  +S++PLA+L+  SI+E HH +    +L+
Sbjct: 635 QNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILN 694

Query: 639 EETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESK-NYQDKKSWVE 697
                I   L+  +++  + ++  AI+ATDLALY K+R  F +++ +++ N +D      
Sbjct: 695 SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPH---- 750

Query: 698 YLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIP 757
                  +KE+ +AM+MTACDLSAITKPW +Q ++A LVA EF++QGD ER  L+ +P  
Sbjct: 751 -------QKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTD 803

Query: 758 MMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYE 815
           +M+R K  ++P +QVGFID +C  +Y+  +   E+  P+ D  + NR++W+ALA++ E
Sbjct: 804 LMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 861



 Score = 34.7 bits (78), Expect = 0.39
 Identities = 29/153 (18%), Positives = 72/153 (47%), Gaps = 8/153 (5%)

Query: 50  LCQVEESTALLELVQDM-QESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELAT 108
           L + + +  LL+L   + +E  ++E ++ K+   + + +Q  +C++F+  +    ++  +
Sbjct: 324 LLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDE--DCSDSFS 381

Query: 109 RLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHF---SSFAD 165
            +F ++ + + +             ++     +V  T + +N+ DV++   F   +    
Sbjct: 382 SVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTG 441

Query: 166 ELTDYKTKNMLATPIMNGK--DVVAVIMAVNKL 196
            +     +++L TPI NGK   V+ V   VNK+
Sbjct: 442 NVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKM 474


>gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens]
          Length = 823

 Score =  406 bits (1044), Expect = e-113
 Identities = 253/778 (32%), Positives = 418/778 (53%), Gaps = 79/778 (10%)

Query: 54  EESTALLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAE-LATRLFS 112
           ++ + LLELV+D+   +++  +  K+   +  L+ ADR SLF+  + +   + L +RLF 
Sbjct: 95  DQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFD 154

Query: 113 VQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKT 172
           V   S LE+     ++ I    + G+VGHVA   + +N++D  E P F++  D++T YKT
Sbjct: 155 VAEGSTLEEV---SNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKT 211

Query: 173 KNMLATPIMNGKD-VVAVIMAVNKL--NGPFFTSEDEDVFLKYLNFATLYL---KIYHLS 226
           +++L  PI N ++ VV V  A+NK   NG  FT +DE  F  YL F  + L   ++Y  S
Sbjct: 212 QSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETS 271

Query: 227 YLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEF 286
            L N   +R QVLL  A+ +FEE   +E    K   T+ +++  ++ ++ ++D      F
Sbjct: 272 LLEN---KRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSF 328

Query: 287 FDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPS 346
             V+ +   E +  S   T +              H   +I  +                
Sbjct: 329 SSVFHMECEELEKSSDTLTRE--------------HDANKINYM-------------YAQ 361

Query: 347 YVAESGFICNIMNASADEMFKFQ-EGALDDSGWLIKNVLSMPIVN-KKEEIVGVATFYNR 404
           YV  +    NI + S D+ F +  E   + +   I+++L  PI N KK +++GV    N+
Sbjct: 362 YVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNK 421

Query: 405 KDG-----KPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 459
            +      KPF+  DE  +E+   F G  + NT  Y+ + +   ++ +  +++ YH    
Sbjct: 422 MEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAA 481

Query: 460 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 519
            +E +                   EL  +    +P   T  I +F FSD E ++L+   C
Sbjct: 482 EEETR-------------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALC 522

Query: 520 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKL 578
            I+M+ +L +V+ FQ+  EVL R++ S+ K YR+ + YHNWRH FN AQ MF  L  GK+
Sbjct: 523 TIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKI 582

Query: 579 KSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLS 638
           ++  TDLE  A++ A L HD+DHRG NN Y  +S++PLA+L+  SI+E HH +    +L+
Sbjct: 583 QNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILN 642

Query: 639 EETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESK-NYQDKKSWVE 697
                I   L+  +++  + ++  AI+ATDLALY K+R  F +++ +++ N +D      
Sbjct: 643 SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPH---- 698

Query: 698 YLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIP 757
                  +KE+ +AM+MTACDLSAITKPW +Q ++A LVA EF++QGD ER  L+ +P  
Sbjct: 699 -------QKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTD 751

Query: 758 MMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYE 815
           +M+R K  ++P +QVGFID +C  +Y+  +   E+  P+ D  + NR++W+ALA++ E
Sbjct: 752 LMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 809



 Score = 34.7 bits (78), Expect = 0.39
 Identities = 29/153 (18%), Positives = 72/153 (47%), Gaps = 8/153 (5%)

Query: 50  LCQVEESTALLELVQDM-QESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELAT 108
           L + + +  LL+L   + +E  ++E ++ K+   + + +Q  +C++F+  +    ++  +
Sbjct: 272 LLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDE--DCSDSFS 329

Query: 109 RLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHF---SSFAD 165
            +F ++ + + +             ++     +V  T + +N+ DV++   F   +    
Sbjct: 330 SVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTG 389

Query: 166 ELTDYKTKNMLATPIMNGK--DVVAVIMAVNKL 196
            +     +++L TPI NGK   V+ V   VNK+
Sbjct: 390 NVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKM 422


>gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens]
          Length = 833

 Score =  406 bits (1044), Expect = e-113
 Identities = 253/778 (32%), Positives = 418/778 (53%), Gaps = 79/778 (10%)

Query: 54  EESTALLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAE-LATRLFS 112
           ++ + LLELV+D+   +++  +  K+   +  L+ ADR SLF+  + +   + L +RLF 
Sbjct: 105 DQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFD 164

Query: 113 VQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKT 172
           V   S LE+     ++ I    + G+VGHVA   + +N++D  E P F++  D++T YKT
Sbjct: 165 VAEGSTLEEV---SNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKT 221

Query: 173 KNMLATPIMNGKD-VVAVIMAVNKL--NGPFFTSEDEDVFLKYLNFATLYL---KIYHLS 226
           +++L  PI N ++ VV V  A+NK   NG  FT +DE  F  YL F  + L   ++Y  S
Sbjct: 222 QSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETS 281

Query: 227 YLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEF 286
            L N   +R QVLL  A+ +FEE   +E    K   T+ +++  ++ ++ ++D      F
Sbjct: 282 LLEN---KRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSF 338

Query: 287 FDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPS 346
             V+ +   E +  S   T +              H   +I  +                
Sbjct: 339 SSVFHMECEELEKSSDTLTRE--------------HDANKINYM-------------YAQ 371

Query: 347 YVAESGFICNIMNASADEMFKFQ-EGALDDSGWLIKNVLSMPIVN-KKEEIVGVATFYNR 404
           YV  +    NI + S D+ F +  E   + +   I+++L  PI N KK +++GV    N+
Sbjct: 372 YVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNK 431

Query: 405 KDG-----KPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 459
            +      KPF+  DE  +E+   F G  + NT  Y+ + +   ++ +  +++ YH    
Sbjct: 432 MEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAA 491

Query: 460 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 519
            +E +                   EL  +    +P   T  I +F FSD E ++L+   C
Sbjct: 492 EEETR-------------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALC 532

Query: 520 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKL 578
            I+M+ +L +V+ FQ+  EVL R++ S+ K YR+ + YHNWRH FN AQ MF  L  GK+
Sbjct: 533 TIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKI 592

Query: 579 KSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLS 638
           ++  TDLE  A++ A L HD+DHRG NN Y  +S++PLA+L+  SI+E HH +    +L+
Sbjct: 593 QNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILN 652

Query: 639 EETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESK-NYQDKKSWVE 697
                I   L+  +++  + ++  AI+ATDLALY K+R  F +++ +++ N +D      
Sbjct: 653 SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPH---- 708

Query: 698 YLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIP 757
                  +KE+ +AM+MTACDLSAITKPW +Q ++A LVA EF++QGD ER  L+ +P  
Sbjct: 709 -------QKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTD 761

Query: 758 MMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYE 815
           +M+R K  ++P +QVGFID +C  +Y+  +   E+  P+ D  + NR++W+ALA++ E
Sbjct: 762 LMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 819



 Score = 34.7 bits (78), Expect = 0.39
 Identities = 29/153 (18%), Positives = 72/153 (47%), Gaps = 8/153 (5%)

Query: 50  LCQVEESTALLELVQDM-QESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELAT 108
           L + + +  LL+L   + +E  ++E ++ K+   + + +Q  +C++F+  +    ++  +
Sbjct: 282 LLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDE--DCSDSFS 339

Query: 109 RLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHF---SSFAD 165
            +F ++ + + +             ++     +V  T + +N+ DV++   F   +    
Sbjct: 340 SVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTG 399

Query: 166 ELTDYKTKNMLATPIMNGK--DVVAVIMAVNKL 196
            +     +++L TPI NGK   V+ V   VNK+
Sbjct: 400 NVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKM 432


>gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens]
          Length = 683

 Score =  380 bits (977), Expect = e-105
 Identities = 227/656 (34%), Positives = 347/656 (52%), Gaps = 60/656 (9%)

Query: 160 FSSFADELTDYKTKNMLATPIMNGK-DVVAVIMAVNKL-NGPFFTSEDEDVFLKYLNFAT 217
           F+   D+LT YKTK++L  PI +   +++ V  A+NK+  G  FT +DE V   YL F  
Sbjct: 58  FNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCG 117

Query: 218 LYLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGL 277
           + +    L      E  R + LL   N +FEE TD+E+   K  +  +  L CER SV L
Sbjct: 118 IAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLL 177

Query: 278 LDMTKEKEFFDVWSVLMGESQPYS--GPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSA 335
           L+        D+ S ++  ++ +    P+     E  F          KE ++     S 
Sbjct: 178 LE--------DIESPVVKFTKSFELMSPKCSADAENSF----------KESME---KSSY 216

Query: 336 DHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEI 395
             W + + +   VA +G   NI +A  D  F  +   +  SG+ I++VL +PI N   +I
Sbjct: 217 SDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNSNHQI 274

Query: 396 VGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYH 455
           +GVA   NR DGKPFD+ D+ L E+   F G  + NT  YD++ K   ++ +A D++ YH
Sbjct: 275 IGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYH 334

Query: 456 VKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELD 515
             C + E+         L  E A                      I + HF D       
Sbjct: 335 ATCSKAEVDKFKAANIPLVSELA----------------------IDDIHFDDFSLDVDA 372

Query: 516 LVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMT 575
           ++   ++M+ ELG+V+KF+I  E L R+L ++ K YR + YHNWRH FNV Q MF +L T
Sbjct: 373 MITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTT 432

Query: 576 GKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEFGK 634
              +   T++E  A++   LCHD+DHRGTNN +Q KS + LA+L+G S+ LE HH     
Sbjct: 433 AGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAV 492

Query: 635 FLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKS 694
            +L  E  NI+ NL+ +++  ++ L+  +I+ATDL LYF++R  F ++V +         
Sbjct: 493 MILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKG-------- 544

Query: 695 WVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQ 754
             EY       ++I  +M+MTACDL A+TKPWE+  +VA LV +EF+EQGD ER  L   
Sbjct: 545 --EYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 602

Query: 755 PIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKAL 810
           P  + DRN+  ELP+LQ+ +ID +C  +Y+   + + ++ PM D +  NR +W+ L
Sbjct: 603 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL 658



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 46/175 (26%), Positives = 86/175 (49%), Gaps = 8/175 (4%)

Query: 52  QVEESTALLELVQDM-QESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRL 110
           + E S ALLE+V D+ +E  ++E++V K++ R  TLL+ +RCS+ +           T+ 
Sbjct: 132 EYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKS 191

Query: 111 FSVQPDSVLEDC------LVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFA 164
           F +       D        +   S   + ++  +   VA T   VN+ D  + P F + A
Sbjct: 192 FELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEA 251

Query: 165 DELTDYKTKNMLATPIMNGK-DVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATL 218
           D+++ +  +++L  PI N    ++ V   +N+L+G  F   D+ +F  ++ F  L
Sbjct: 252 DQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGL 306


>gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens]
          Length = 575

 Score =  347 bits (889), Expect = 4e-95
 Identities = 206/602 (34%), Positives = 315/602 (52%), Gaps = 58/602 (9%)

Query: 212 YLNFATLYLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCE 271
           YL F  + +    L      E  R + LL   N +FEE TD+E+   K  +  +  L CE
Sbjct: 4   YLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCE 63

Query: 272 RYSVGLLDMTKEKEFFDVWSVLMGESQPYS--GPRTPDGREIVFYKVIDYILHGKEEIKV 329
           R SV LL+        D+ S ++  ++ +    P+     E  F          KE ++ 
Sbjct: 64  RCSVLLLE--------DIESPVVKFTKSFELMSPKCSADAENSF----------KESME- 104

Query: 330 IPTPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIV 389
               S   W + + +   VA +G   NI +A  D  F  +   +  SG+ I++VL +PI 
Sbjct: 105 --KSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIW 160

Query: 390 NKKEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQ 449
           N   +I+GVA   NR DGKPFD+ D+ L E+   F G  + NT  YD++ K   ++ +A 
Sbjct: 161 NSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVAL 220

Query: 450 DMVLYHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDL 509
           D++ YH  C + E+         L  E A                      I + HF D 
Sbjct: 221 DVLSYHATCSKAEVDKFKAANIPLVSELA----------------------IDDIHFDDF 258

Query: 510 ECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTM 569
                 ++   ++M+ ELG+V+KF+I  E L R+L ++ K YR + YHNWRH FNV Q M
Sbjct: 259 SLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLM 318

Query: 570 FTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERH 628
           F +L T   +   T++E  A++   LCHD+DHRGTNN +Q KS + LA+L+G S+ LE H
Sbjct: 319 FAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHH 378

Query: 629 HLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKN 688
           H      +L  E  NI+ NL+ +++  ++ L+  +I+ATDL LYF++R  F ++V +   
Sbjct: 379 HFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKG-- 436

Query: 689 YQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLER 748
                   EY       ++I  +M+MTACDL A+TKPWE+  +VA LV +EF+EQGD ER
Sbjct: 437 --------EYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRER 488

Query: 749 TVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWK 808
             L   P  + DRN+  ELP+LQ+ +ID +C  +Y+   + + ++ PM D +  NR +W+
Sbjct: 489 LELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWE 548

Query: 809 AL 810
            L
Sbjct: 549 EL 550



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 46/175 (26%), Positives = 86/175 (49%), Gaps = 8/175 (4%)

Query: 52  QVEESTALLELVQDM-QESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRL 110
           + E S ALLE+V D+ +E  ++E++V K++ R  TLL+ +RCS+ +           T+ 
Sbjct: 24  EYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKS 83

Query: 111 FSVQPDSVLEDC------LVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFA 164
           F +       D        +   S   + ++  +   VA T   VN+ D  + P F + A
Sbjct: 84  FELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEA 143

Query: 165 DELTDYKTKNMLATPIMNGK-DVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATL 218
           D+++ +  +++L  PI N    ++ V   +N+L+G  F   D+ +F  ++ F  L
Sbjct: 144 DQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGL 198


>gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens]
          Length = 489

 Score =  326 bits (836), Expect = 5e-89
 Identities = 175/478 (36%), Positives = 266/478 (55%), Gaps = 35/478 (7%)

Query: 334 SADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKE 393
           S   W + + +   VA +G   NI +A  D  F  +   +  SG+ I++VL +PI N   
Sbjct: 21  SYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNSNH 78

Query: 394 EIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVL 453
           +I+GVA   NR DGKPFD+ D+ L E+   F G  + NT  YD++ K   ++ +A D++ 
Sbjct: 79  QIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLS 138

Query: 454 YHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTE 513
           YH  C + E+         L  E A                      I + HF D     
Sbjct: 139 YHATCSKAEVDKFKAANIPLVSELA----------------------IDDIHFDDFSLDV 176

Query: 514 LDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLL 573
             ++   ++M+ ELG+V+KF+I  E L R+L ++ K YR + YHNWRH FNV Q MF +L
Sbjct: 177 DAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAML 236

Query: 574 MTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEF 632
            T   +   T++E  A++   LCHD+DHRGTNN +Q KS + LA+L+G S+ LE HH   
Sbjct: 237 TTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNH 296

Query: 633 GKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDK 692
              +L  E  NI+ NL+ +++  ++ L+  +I+ATDL LYF++R  F ++V +       
Sbjct: 297 AVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKG------ 350

Query: 693 KSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLD 752
               EY       ++I  +M+MTACDL A+TKPWE+  +VA LV +EF+EQGD ER  L 
Sbjct: 351 ----EYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELK 406

Query: 753 QQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKAL 810
             P  + DRN+  ELP+LQ+ +ID +C  +Y+   + + ++ PM D +  NR +W+ L
Sbjct: 407 LTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL 464



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 23/78 (29%), Positives = 42/78 (53%), Gaps = 1/78 (1%)

Query: 142 VAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPIMNGK-DVVAVIMAVNKLNGPF 200
           VA T   VN+ D  + P F + AD+++ +  +++L  PI N    ++ V   +N+L+G  
Sbjct: 35  VASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKP 94

Query: 201 FTSEDEDVFLKYLNFATL 218
           F   D+ +F  ++ F  L
Sbjct: 95  FDDADQRLFEAFVIFCGL 112


>gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens]
          Length = 932

 Score =  283 bits (725), Expect = 4e-76
 Identities = 217/806 (26%), Positives = 375/806 (46%), Gaps = 109/806 (13%)

Query: 59  LLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSV 118
           +L+L  ++ + ++   +  KVL+ L    +A RC L +  + N   +L+ ++     D V
Sbjct: 221 ILQLCGELYD-LDASSLQLKVLQYLQQETRASRCCLLLVSEDN--LQLSCKVIG---DKV 274

Query: 119 LEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLAT 178
           L +       E+ FPL  G +G V + KK + ++D+            +   + + ML  
Sbjct: 275 LGE-------EVSFPLT-GCLGQVVEDKKSIQLKDLTS--EDVQQLQSMLGCELQAMLCV 324

Query: 179 PIMNGK--DVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLK---IYHLSYLHNCET 233
           P+++     VVA+  A NKL G  FT EDE V     ++ +  L     +       CE 
Sbjct: 325 PVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCEC 384

Query: 234 RRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVL 293
              Q LL  A  +F  L D+     +     R   N E  SV LLD  +           
Sbjct: 385 ---QALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNE----------- 430

Query: 294 MGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKV-IPTPSADHWALASGLPSYVAESG 352
                             +  KV D  +   E  ++ IP           G+  +VA +G
Sbjct: 431 ------------------LVAKVFDGGVVDDESYEIRIPADQ--------GIAGHVATTG 464

Query: 353 FICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDE 412
            I NI +A A  +F    G  D +G+  +N+L  PI N+ +E++GVA   N+ +G  F +
Sbjct: 465 QILNIPDAYAHPLF--YRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSK 522

Query: 413 QDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRAR 472
            DE L  + + + G S+ ++  Y K+N+ + R  +A +M++YH+K   DE   +L     
Sbjct: 523 FDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD--- 579

Query: 473 LGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRK 532
            G +P    +                     F ++     E D     + M  ++  +  
Sbjct: 580 -GIQPVAAIDSNFAS----------------FTYTPRSLPEDDTSMAILSMLQDMNFINN 622

Query: 533 FQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVT 592
           ++I    L RF   + KGYR   YHNW H F+V+   + L    +L +Y  D+E FA+  
Sbjct: 623 YKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFI 682

Query: 593 AGLCHDIDHRGTNNLYQMKSQNPLAKLHGS--SILERHHLEFGKFLLSEETLNIYQNLNR 650
           + +CHD+DHRGTNN +Q+ S++ LA L+ S  S++ERHH      +L+    NI+ + +R
Sbjct: 683 SCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSR 742

Query: 651 RQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVM 710
           + ++ ++ LM   I+ATDLA + +     QK+ +   +  +K+              +++
Sbjct: 743 KDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQ-----------HHRLLL 791

Query: 711 AMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKL 770
            ++MT+CDLS  TK W+   K+A L+  EF+ QGDLE+  +  +P+ MMDR K A +P+L
Sbjct: 792 CLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMDREK-AYIPEL 849

Query: 771 QVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAK----VKALEEKEE 826
           Q+ F++ +   +YK       +   +++R+ +NR+ W  ++ ++  +      +L+  +E
Sbjct: 850 QISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDE 909

Query: 827 EERVAAKKGTEICNGGPAPKSSTCCI 852
           E  V    GT       AP +  C +
Sbjct: 910 EYEVPDLDGTR------APINGCCSL 929



 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 65/255 (25%), Positives = 120/255 (47%), Gaps = 29/255 (11%)

Query: 55  ESTALLELVQDMQESINMERVVFK-VLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSV 113
           E  ALL++ +++   ++   V+ + ++     L  A+ CS+F+  Q     EL  ++F  
Sbjct: 383 ECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQN----ELVAKVFD- 437

Query: 114 QPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTK 173
               V++D       EI  P D G+ GHVA T +++N+ D    P F    D+ T ++T+
Sbjct: 438 --GGVVDD----ESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTR 491

Query: 174 NMLATPIMN-GKDVVAVIMAVNKLNGPFFTSEDEDVFLKY-------LNFATLYLKIYHL 225
           N+L  PI N  ++V+ V   VNK+NGP+F+  DED+   +       +  + LY K+   
Sbjct: 492 NILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEA 551

Query: 226 SYLHNCETRRGQVLLWSANKVFEEL--------TDIERQFHKAFYTVRAYLNCERYSVGL 277
            Y  +         +  ++  + +L          I+  F    YT R+ L  +  S+ +
Sbjct: 552 QYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRS-LPEDDTSMAI 610

Query: 278 LDMTKEKEFFDVWSV 292
           L M ++  F + + +
Sbjct: 611 LSMLQDMNFINNYKI 625


>gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens]
          Length = 934

 Score =  283 bits (725), Expect = 4e-76
 Identities = 217/806 (26%), Positives = 375/806 (46%), Gaps = 109/806 (13%)

Query: 59  LLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSV 118
           +L+L  ++ + ++   +  KVL+ L    +A RC L +  + N   +L+ ++     D V
Sbjct: 223 ILQLCGELYD-LDASSLQLKVLQYLQQETRASRCCLLLVSEDN--LQLSCKVIG---DKV 276

Query: 119 LEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLAT 178
           L +       E+ FPL  G +G V + KK + ++D+            +   + + ML  
Sbjct: 277 LGE-------EVSFPLT-GCLGQVVEDKKSIQLKDLTS--EDVQQLQSMLGCELQAMLCV 326

Query: 179 PIMNGK--DVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLK---IYHLSYLHNCET 233
           P+++     VVA+  A NKL G  FT EDE V     ++ +  L     +       CE 
Sbjct: 327 PVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCEC 386

Query: 234 RRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVL 293
              Q LL  A  +F  L D+     +     R   N E  SV LLD  +           
Sbjct: 387 ---QALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNE----------- 432

Query: 294 MGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKV-IPTPSADHWALASGLPSYVAESG 352
                             +  KV D  +   E  ++ IP           G+  +VA +G
Sbjct: 433 ------------------LVAKVFDGGVVDDESYEIRIPADQ--------GIAGHVATTG 466

Query: 353 FICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDE 412
            I NI +A A  +F    G  D +G+  +N+L  PI N+ +E++GVA   N+ +G  F +
Sbjct: 467 QILNIPDAYAHPLF--YRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSK 524

Query: 413 QDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRAR 472
            DE L  + + + G S+ ++  Y K+N+ + R  +A +M++YH+K   DE   +L     
Sbjct: 525 FDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD--- 581

Query: 473 LGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRK 532
            G +P    +                     F ++     E D     + M  ++  +  
Sbjct: 582 -GIQPVAAIDSNFAS----------------FTYTPRSLPEDDTSMAILSMLQDMNFINN 624

Query: 533 FQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVT 592
           ++I    L RF   + KGYR   YHNW H F+V+   + L    +L +Y  D+E FA+  
Sbjct: 625 YKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFI 684

Query: 593 AGLCHDIDHRGTNNLYQMKSQNPLAKLHGS--SILERHHLEFGKFLLSEETLNIYQNLNR 650
           + +CHD+DHRGTNN +Q+ S++ LA L+ S  S++ERHH      +L+    NI+ + +R
Sbjct: 685 SCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSR 744

Query: 651 RQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVM 710
           + ++ ++ LM   I+ATDLA + +     QK+ +   +  +K+              +++
Sbjct: 745 KDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQ-----------HHRLLL 793

Query: 711 AMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKL 770
            ++MT+CDLS  TK W+   K+A L+  EF+ QGDLE+  +  +P+ MMDR K A +P+L
Sbjct: 794 CLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMDREK-AYIPEL 851

Query: 771 QVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAK----VKALEEKEE 826
           Q+ F++ +   +YK       +   +++R+ +NR+ W  ++ ++  +      +L+  +E
Sbjct: 852 QISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDE 911

Query: 827 EERVAAKKGTEICNGGPAPKSSTCCI 852
           E  V    GT       AP +  C +
Sbjct: 912 EYEVPDLDGTR------APINGCCSL 931



 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 65/255 (25%), Positives = 120/255 (47%), Gaps = 29/255 (11%)

Query: 55  ESTALLELVQDMQESINMERVVFK-VLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSV 113
           E  ALL++ +++   ++   V+ + ++     L  A+ CS+F+  Q     EL  ++F  
Sbjct: 385 ECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQN----ELVAKVFD- 439

Query: 114 QPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTK 173
               V++D       EI  P D G+ GHVA T +++N+ D    P F    D+ T ++T+
Sbjct: 440 --GGVVDD----ESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTR 493

Query: 174 NMLATPIMN-GKDVVAVIMAVNKLNGPFFTSEDEDVFLKY-------LNFATLYLKIYHL 225
           N+L  PI N  ++V+ V   VNK+NGP+F+  DED+   +       +  + LY K+   
Sbjct: 494 NILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEA 553

Query: 226 SYLHNCETRRGQVLLWSANKVFEEL--------TDIERQFHKAFYTVRAYLNCERYSVGL 277
            Y  +         +  ++  + +L          I+  F    YT R+ L  +  S+ +
Sbjct: 554 QYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRS-LPEDDTSMAI 612

Query: 278 LDMTKEKEFFDVWSV 292
           L M ++  F + + +
Sbjct: 613 LSMLQDMNFINNYKI 627


>gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens]
          Length = 941

 Score =  283 bits (725), Expect = 4e-76
 Identities = 217/806 (26%), Positives = 375/806 (46%), Gaps = 109/806 (13%)

Query: 59  LLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSV 118
           +L+L  ++ + ++   +  KVL+ L    +A RC L +  + N   +L+ ++     D V
Sbjct: 230 ILQLCGELYD-LDASSLQLKVLQYLQQETRASRCCLLLVSEDN--LQLSCKVIG---DKV 283

Query: 119 LEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLAT 178
           L +       E+ FPL  G +G V + KK + ++D+            +   + + ML  
Sbjct: 284 LGE-------EVSFPLT-GCLGQVVEDKKSIQLKDLTS--EDVQQLQSMLGCELQAMLCV 333

Query: 179 PIMNGK--DVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLK---IYHLSYLHNCET 233
           P+++     VVA+  A NKL G  FT EDE V     ++ +  L     +       CE 
Sbjct: 334 PVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCEC 393

Query: 234 RRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVL 293
              Q LL  A  +F  L D+     +     R   N E  SV LLD  +           
Sbjct: 394 ---QALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNE----------- 439

Query: 294 MGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKV-IPTPSADHWALASGLPSYVAESG 352
                             +  KV D  +   E  ++ IP           G+  +VA +G
Sbjct: 440 ------------------LVAKVFDGGVVDDESYEIRIPADQ--------GIAGHVATTG 473

Query: 353 FICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDE 412
            I NI +A A  +F    G  D +G+  +N+L  PI N+ +E++GVA   N+ +G  F +
Sbjct: 474 QILNIPDAYAHPLF--YRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSK 531

Query: 413 QDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRAR 472
            DE L  + + + G S+ ++  Y K+N+ + R  +A +M++YH+K   DE   +L     
Sbjct: 532 FDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD--- 588

Query: 473 LGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRK 532
            G +P    +                     F ++     E D     + M  ++  +  
Sbjct: 589 -GIQPVAAIDSNFAS----------------FTYTPRSLPEDDTSMAILSMLQDMNFINN 631

Query: 533 FQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVT 592
           ++I    L RF   + KGYR   YHNW H F+V+   + L    +L +Y  D+E FA+  
Sbjct: 632 YKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFI 691

Query: 593 AGLCHDIDHRGTNNLYQMKSQNPLAKLHGS--SILERHHLEFGKFLLSEETLNIYQNLNR 650
           + +CHD+DHRGTNN +Q+ S++ LA L+ S  S++ERHH      +L+    NI+ + +R
Sbjct: 692 SCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSR 751

Query: 651 RQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVM 710
           + ++ ++ LM   I+ATDLA + +     QK+ +   +  +K+              +++
Sbjct: 752 KDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQ-----------HHRLLL 800

Query: 711 AMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKL 770
            ++MT+CDLS  TK W+   K+A L+  EF+ QGDLE+  +  +P+ MMDR K A +P+L
Sbjct: 801 CLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMDREK-AYIPEL 858

Query: 771 QVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAK----VKALEEKEE 826
           Q+ F++ +   +YK       +   +++R+ +NR+ W  ++ ++  +      +L+  +E
Sbjct: 859 QISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDE 918

Query: 827 EERVAAKKGTEICNGGPAPKSSTCCI 852
           E  V    GT       AP +  C +
Sbjct: 919 EYEVPDLDGTR------APINGCCSL 938



 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 65/255 (25%), Positives = 120/255 (47%), Gaps = 29/255 (11%)

Query: 55  ESTALLELVQDMQESINMERVVFK-VLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSV 113
           E  ALL++ +++   ++   V+ + ++     L  A+ CS+F+  Q     EL  ++F  
Sbjct: 392 ECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQN----ELVAKVFD- 446

Query: 114 QPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTK 173
               V++D       EI  P D G+ GHVA T +++N+ D    P F    D+ T ++T+
Sbjct: 447 --GGVVDD----ESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTR 500

Query: 174 NMLATPIMN-GKDVVAVIMAVNKLNGPFFTSEDEDVFLKY-------LNFATLYLKIYHL 225
           N+L  PI N  ++V+ V   VNK+NGP+F+  DED+   +       +  + LY K+   
Sbjct: 501 NILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEA 560

Query: 226 SYLHNCETRRGQVLLWSANKVFEEL--------TDIERQFHKAFYTVRAYLNCERYSVGL 277
            Y  +         +  ++  + +L          I+  F    YT R+ L  +  S+ +
Sbjct: 561 QYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRS-LPEDDTSMAI 619

Query: 278 LDMTKEKEFFDVWSV 292
           L M ++  F + + +
Sbjct: 620 LSMLQDMNFINNYKI 634


>gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens]
          Length = 789

 Score =  232 bits (592), Expect = 1e-60
 Identities = 211/833 (25%), Positives = 372/833 (44%), Gaps = 118/833 (14%)

Query: 2   SLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALLE 61
           SL++E+ +++L  +P    ++  + +S E V    +          R   + E+ +A  E
Sbjct: 23  SLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLK----------RKNNKSEDESAPKE 72

Query: 62  LVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATR------------ 109
           + +   +  NM+ VV+++   +   L     +  +  + + + ++AT+            
Sbjct: 73  VSR--YQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGEC 130

Query: 110 ---LFSVQPDSVLEDC--LVPPDSEIVFPLDIG--VVGHVAQTKKMVNVEDVAECPHFSS 162
              L    P  + E    L+P       P+  G  V  +VA+++K + VED+     F  
Sbjct: 131 NNSLCIFTPPGIKEGKPRLIPAG-----PITQGTTVSAYVAKSRKTLLVEDILGDERFPR 185

Query: 163 FADELTDYKTKNMLATPIMNG-KDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLK 221
                +  + +++L  PI+    D++ ++          F    ++V    L +A++ + 
Sbjct: 186 GTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIH 245

Query: 222 IYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMT 281
              +      +T     LL  +   F+ +  I+          +  +N +R ++  +D  
Sbjct: 246 QVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHK 305

Query: 282 KEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALA 341
            ++ + D++ +  GE +        +G+  VF K         +EI+         +++ 
Sbjct: 306 NKELYSDLFDI--GEEK--------EGKP-VFKKT--------KEIR---------FSIE 337

Query: 342 SGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATF 401
            G+   VA +G + NI +A AD  F  +      +G+  +N+L MPIV++   ++GV   
Sbjct: 338 KGIAGQVARTGEVLNIPDAYADPRFNREVDLY--TGYTTRNILCMPIVSRGS-VIGVVQM 394

Query: 402 YNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRD 461
            N+  G  F + DE   +    F   ++   + Y ++   E    +  + + YH  C  +
Sbjct: 395 VNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSE 454

Query: 462 E----IQLILPTRARLGKEPADCDEDELG--EILKEELPGPTTFDIYEFHFSDLECTELD 515
           E    +Q  LP R         C E EL   +I   E   P  F +Y  H S        
Sbjct: 455 EWQGLMQFTLPVRL--------CKEIELFHFDIGPFENMWPGIF-VYMVHRS-------- 497

Query: 516 LVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMT 575
              CG   + EL          E L RF+ S+ K YRR+ YHNW+H   VA  M+ +L  
Sbjct: 498 ---CGTSCF-EL----------EKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQN 543

Query: 576 GKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKF 635
               + +TDLE   ++ A LCHD+DHRG +N Y  K  +PLA L+ +S +E+HH      
Sbjct: 544 NH--TLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVS 601

Query: 636 LLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSW 695
           +L  E  NI+  L+  ++E V+ ++  AIIATDLALYF  R   +++        + +S 
Sbjct: 602 ILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQS- 660

Query: 696 VEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQP 755
                     ++ V+ +MMTACDL ++TK W V    A  + AEFW +GD E   L  QP
Sbjct: 661 ---------HRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGD-EMKKLGIQP 710

Query: 756 IPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWK 808
           IPMMDR+K  E+P+ Q+GF + V    Y   ++      P+    ++N  +W+
Sbjct: 711 IPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWE 763


>gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens]
          Length = 779

 Score =  231 bits (588), Expect = 3e-60
 Identities = 185/678 (27%), Positives = 312/678 (46%), Gaps = 82/678 (12%)

Query: 138 VVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPIMNG-KDVVAVIMAVNKL 196
           V  +VA+++K + VED+     F       +  + +++L  PI+    D++ ++      
Sbjct: 151 VSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHW 210

Query: 197 NGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQ 256
               F    ++V    L +A++ +    +      +T     LL  +   F+ +  I+  
Sbjct: 211 GKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSL 270

Query: 257 FHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKV 316
                   +  +N +R ++  +D   ++ + D++ +  GE +        +G+  VF K 
Sbjct: 271 LEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDI--GEEK--------EGKP-VFKKT 319

Query: 317 IDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDS 376
                   +EI+         +++  G+   VA +G + NI +A AD  F  +      +
Sbjct: 320 --------KEIR---------FSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLY--T 360

Query: 377 GWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYD 436
           G+  +N+L MPIV++   ++GV    N+  G  F + DE   +    F   ++   + Y 
Sbjct: 361 GYTTRNILCMPIVSRGS-VIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYH 419

Query: 437 KMNKLENRKDIAQDMVLYHVKCDRDE----IQLILPTRARLGKEPADCDEDELG--EILK 490
           ++   E    +  + + YH  C  +E    +Q  LP R         C E EL   +I  
Sbjct: 420 RIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRL--------CKEIELFHFDIGP 471

Query: 491 EELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKG 550
            E   P  F +Y  H S           CG   + EL          E L RF+ S+ K 
Sbjct: 472 FENMWPGIF-VYMVHRS-----------CGTSCF-EL----------EKLCRFIMSVKKN 508

Query: 551 YRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQM 610
           YRR+ YHNW+H   VA  M+ +L      + +TDLE   ++ A LCHD+DHRG +N Y  
Sbjct: 509 YRRVPYHNWKHAVTVAHCMYAILQNNH--TLFTDLERKGLLIACLCHDLDHRGFSNSYLQ 566

Query: 611 KSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLA 670
           K  +PLA L+ +S +E+HH      +L  E  NI+  L+  ++E V+ ++  AIIATDLA
Sbjct: 567 KFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLA 626

Query: 671 LYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQS 730
           LYF  R   +++        + +S           ++ V+ +MMTACDL ++TK W V  
Sbjct: 627 LYFGNRKQLEEMYQTGSLNLNNQS----------HRDRVIGLMMTACDLCSVTKLWPVTK 676

Query: 731 KVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFH 790
             A  + AEFW +GD E   L  QPIPMMDR+K  E+P+ Q+GF + V    Y   ++  
Sbjct: 677 LTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQIL 735

Query: 791 EEILPMFDRLQNNRKEWK 808
               P+    ++N  +W+
Sbjct: 736 PPTEPLLKACRDNLSQWE 753



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 47/142 (33%), Positives = 76/142 (53%), Gaps = 6/142 (4%)

Query: 86  LLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQT 145
           L+ ADRC+LF    +N   EL + LF +  +   +  +     EI F ++ G+ G VA+T
Sbjct: 281 LVNADRCALFQVDHKN--KELYSDLFDIGEEKEGKP-VFKKTKEIRFSIEKGIAGQVART 337

Query: 146 KKMVNVEDVAECPHFSSFADELTDYKTKNMLATPIMNGKDVVAVIMAVNKLNGPFFTSED 205
            +++N+ D    P F+   D  T Y T+N+L  PI++   V+ V+  VNK++G  F+  D
Sbjct: 338 GEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTD 397

Query: 206 EDVFLKYLNFATLYL---KIYH 224
           E+ F  +  F  L L    +YH
Sbjct: 398 ENNFKMFAVFCALALHCANMYH 419


>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
          Length = 809

 Score =  142 bits (357), Expect = 2e-33
 Identities = 98/327 (29%), Positives = 175/327 (53%), Gaps = 11/327 (3%)

Query: 484 ELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRF 543
           E  ++L +EL     + ++ F  ++L      L      ++ E  +++ F+IP + L+ +
Sbjct: 389 EQEDVLAKELEDVNKWGLHVFRIAELSGNR-PLTVIMHTIFQERDLLKTFKIPVDTLITY 447

Query: 544 LFSISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHR 602
           L ++   Y   + YHN  H  +V Q+   LL T  L++ +TDLE  A + A   HD+DH 
Sbjct: 448 LMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHP 507

Query: 603 GTNNLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMD 661
           G +N + + + + LA ++  SS+LE HHL  G  LL EE  +I+QNL ++Q + +  ++ 
Sbjct: 508 GVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVI 567

Query: 662 IAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSA 721
             ++ATD++ +    A  + +V+  K      S V  L   + R +++  M+  A DLS 
Sbjct: 568 DIVLATDMSKHMNLLADLKTMVETKK---VTSSGVLLLDNYSDRIQVLQNMVHCA-DLSN 623

Query: 722 ITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTF 781
            TKP ++  +    +  EF+ QGD ER     +  PM D++ A+ + K QVGFID++   
Sbjct: 624 PTKPLQLYRQWTDRIMEEFFRQGDRERE-RGMEISPMCDKHNAS-VEKSQVGFIDYIVHP 681

Query: 782 VYKEFSRF-HEEILPMFDRLQNNRKEW 807
           +++ ++   H +   + D L++NR EW
Sbjct: 682 LWETWADLVHPDAQDILDTLEDNR-EW 707


>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
          Length = 673

 Score =  142 bits (357), Expect = 2e-33
 Identities = 98/327 (29%), Positives = 175/327 (53%), Gaps = 11/327 (3%)

Query: 484 ELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRF 543
           E  ++L +EL     + ++ F  ++L      L      ++ E  +++ F+IP + L+ +
Sbjct: 253 EQEDVLAKELEDVNKWGLHVFRIAELSGNR-PLTVIMHTIFQERDLLKTFKIPVDTLITY 311

Query: 544 LFSISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHR 602
           L ++   Y   + YHN  H  +V Q+   LL T  L++ +TDLE  A + A   HD+DH 
Sbjct: 312 LMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHP 371

Query: 603 GTNNLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMD 661
           G +N + + + + LA ++  SS+LE HHL  G  LL EE  +I+QNL ++Q + +  ++ 
Sbjct: 372 GVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVI 431

Query: 662 IAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSA 721
             ++ATD++ +    A  + +V+  K      S V  L   + R +++  M+  A DLS 
Sbjct: 432 DIVLATDMSKHMNLLADLKTMVETKK---VTSSGVLLLDNYSDRIQVLQNMVHCA-DLSN 487

Query: 722 ITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTF 781
            TKP ++  +    +  EF+ QGD ER     +  PM D++ A+ + K QVGFID++   
Sbjct: 488 PTKPLQLYRQWTDRIMEEFFRQGDRERE-RGMEISPMCDKHNAS-VEKSQVGFIDYIVHP 545

Query: 782 VYKEFSRF-HEEILPMFDRLQNNRKEW 807
           +++ ++   H +   + D L++NR EW
Sbjct: 546 LWETWADLVHPDAQDILDTLEDNR-EW 571


>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
          Length = 825

 Score =  141 bits (356), Expect = 2e-33
 Identities = 108/367 (29%), Positives = 188/367 (51%), Gaps = 34/367 (9%)

Query: 487 EILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFS 546
           E+L +EL     + +  F  SD       L      ++ E  +++KF+IP + +V ++ +
Sbjct: 302 ELLAQELENLNKWGLNIFCVSDYAGGR-SLTCIMYMIFQERDLLKKFRIPVDTMVTYMLT 360

Query: 547 ISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTN 605
           +   Y   + YHN  H  +V Q+   LL T  L + +TDLE  A + A   HD+DH G +
Sbjct: 361 LEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVS 420

Query: 606 NLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAI 664
           N + + + + LA ++   S+LE HHL  G  LL E+  +I+QNL++RQ + +  ++   +
Sbjct: 421 NQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMV 480

Query: 665 IATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITK 724
           +ATD++ +    A  + +V+  K      S V  L   + R +++  M+  A DLS  TK
Sbjct: 481 LATDMSKHMTLLADLKTMVETKK---VTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 536

Query: 725 PWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYK 784
           P E+  +    + AEF++QGD ER     +  PM D++  A + K QVGFID++   +++
Sbjct: 537 PLELYRQWTDRIMAEFFQQGDRERE-RGMEISPMCDKH-TASVEKSQVGFIDYIVHPLWE 594

Query: 785 EFSRF-HEEILPMFDRLQNNRKEW----------------------KALADEYEAKVKAL 821
            ++   H +   + D L++NR +W                        L D+++ ++  L
Sbjct: 595 TWADLVHPDAQEILDTLEDNR-DWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFEL-TL 652

Query: 822 EEKEEEE 828
           EE+EEEE
Sbjct: 653 EEEEEEE 659


>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
          Length = 860

 Score =  141 bits (356), Expect = 2e-33
 Identities = 108/367 (29%), Positives = 188/367 (51%), Gaps = 34/367 (9%)

Query: 487 EILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFS 546
           E+L +EL     + +  F  SD       L      ++ E  +++KF+IP + +V ++ +
Sbjct: 337 ELLAQELENLNKWGLNIFCVSDYAGGR-SLTCIMYMIFQERDLLKKFRIPVDTMVTYMLT 395

Query: 547 ISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTN 605
           +   Y   + YHN  H  +V Q+   LL T  L + +TDLE  A + A   HD+DH G +
Sbjct: 396 LEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVS 455

Query: 606 NLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAI 664
           N + + + + LA ++   S+LE HHL  G  LL E+  +I+QNL++RQ + +  ++   +
Sbjct: 456 NQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMV 515

Query: 665 IATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITK 724
           +ATD++ +    A  + +V+  K      S V  L   + R +++  M+  A DLS  TK
Sbjct: 516 LATDMSKHMTLLADLKTMVETKK---VTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 571

Query: 725 PWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYK 784
           P E+  +    + AEF++QGD ER     +  PM D++  A + K QVGFID++   +++
Sbjct: 572 PLELYRQWTDRIMAEFFQQGDRERE-RGMEISPMCDKH-TASVEKSQVGFIDYIVHPLWE 629

Query: 785 EFSRF-HEEILPMFDRLQNNRKEW----------------------KALADEYEAKVKAL 821
            ++   H +   + D L++NR +W                        L D+++ ++  L
Sbjct: 630 TWADLVHPDAQEILDTLEDNR-DWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFEL-TL 687

Query: 822 EEKEEEE 828
           EE+EEEE
Sbjct: 688 EEEEEEE 694


>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
          Length = 886

 Score =  141 bits (356), Expect = 2e-33
 Identities = 108/367 (29%), Positives = 188/367 (51%), Gaps = 34/367 (9%)

Query: 487 EILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFS 546
           E+L +EL     + +  F  SD       L      ++ E  +++KF+IP + +V ++ +
Sbjct: 363 ELLAQELENLNKWGLNIFCVSDYAGGR-SLTCIMYMIFQERDLLKKFRIPVDTMVTYMLT 421

Query: 547 ISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTN 605
           +   Y   + YHN  H  +V Q+   LL T  L + +TDLE  A + A   HD+DH G +
Sbjct: 422 LEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVS 481

Query: 606 NLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAI 664
           N + + + + LA ++   S+LE HHL  G  LL E+  +I+QNL++RQ + +  ++   +
Sbjct: 482 NQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMV 541

Query: 665 IATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITK 724
           +ATD++ +    A  + +V+  K      S V  L   + R +++  M+  A DLS  TK
Sbjct: 542 LATDMSKHMTLLADLKTMVETKK---VTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 597

Query: 725 PWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYK 784
           P E+  +    + AEF++QGD ER     +  PM D++  A + K QVGFID++   +++
Sbjct: 598 PLELYRQWTDRIMAEFFQQGDRERE-RGMEISPMCDKH-TASVEKSQVGFIDYIVHPLWE 655

Query: 785 EFSRF-HEEILPMFDRLQNNRKEW----------------------KALADEYEAKVKAL 821
            ++   H +   + D L++NR +W                        L D+++ ++  L
Sbjct: 656 TWADLVHPDAQEILDTLEDNR-DWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFEL-TL 713

Query: 822 EEKEEEE 828
           EE+EEEE
Sbjct: 714 EEEEEEE 720


>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
          Length = 647

 Score =  141 bits (356), Expect = 2e-33
 Identities = 108/367 (29%), Positives = 188/367 (51%), Gaps = 34/367 (9%)

Query: 487 EILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFS 546
           E+L +EL     + +  F  SD       L      ++ E  +++KF+IP + +V ++ +
Sbjct: 124 ELLAQELENLNKWGLNIFCVSDYAGGR-SLTCIMYMIFQERDLLKKFRIPVDTMVTYMLT 182

Query: 547 ISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTN 605
           +   Y   + YHN  H  +V Q+   LL T  L + +TDLE  A + A   HD+DH G +
Sbjct: 183 LEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVS 242

Query: 606 NLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAI 664
           N + + + + LA ++   S+LE HHL  G  LL E+  +I+QNL++RQ + +  ++   +
Sbjct: 243 NQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMV 302

Query: 665 IATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITK 724
           +ATD++ +    A  + +V+  K      S V  L   + R +++  M+  A DLS  TK
Sbjct: 303 LATDMSKHMTLLADLKTMVETKK---VTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 358

Query: 725 PWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYK 784
           P E+  +    + AEF++QGD ER     +  PM D++  A + K QVGFID++   +++
Sbjct: 359 PLELYRQWTDRIMAEFFQQGDRERE-RGMEISPMCDKH-TASVEKSQVGFIDYIVHPLWE 416

Query: 785 EFSRF-HEEILPMFDRLQNNRKEW----------------------KALADEYEAKVKAL 821
            ++   H +   + D L++NR +W                        L D+++ ++  L
Sbjct: 417 TWADLVHPDAQEILDTLEDNR-DWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFEL-TL 474

Query: 822 EEKEEEE 828
           EE+EEEE
Sbjct: 475 EEEEEEE 481


>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
          Length = 606

 Score =  137 bits (345), Expect = 4e-32
 Identities = 106/371 (28%), Positives = 187/371 (50%), Gaps = 30/371 (8%)

Query: 487 EILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFS 546
           E L +EL     + +  F  ++L      L      ++ E  +++ FQIP + L  +L  
Sbjct: 212 EQLAKELEDTNKWGLDVFKVAELSGNR-PLTAIIFSIFQERDLLKTFQIPADTLATYLLM 270

Query: 547 ISKGYR-RITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTN 605
           +   Y   + YHN  H  +VAQ+   LL T  L++ +TDLE  A + A   HD+DH G +
Sbjct: 271 LEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVS 330

Query: 606 NLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAI 664
           N + + + + LA ++  +S+LE HHL  G  LL  E  +I+QNL+ +Q   +  ++   +
Sbjct: 331 NQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMV 390

Query: 665 IATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTAC-DLSAIT 723
           +ATD++ +    A  + +V+       K + +  L L+     I +   +  C DLS  T
Sbjct: 391 LATDMSKHMNLLADLKTMVETK-----KVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPT 445

Query: 724 KPWEVQSKVALLVAAEFWEQGDLER-TVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFV 782
           KP  +  +    + AEF++QGD ER + LD    PM D++  A + K QVGFID++   +
Sbjct: 446 KPLPLYRQWTDRIMAEFFQQGDRERESGLDIS--PMCDKH-TASVEKSQVGFIDYIAHPL 502

Query: 783 YKEFSRF-HEEILPMFDRLQNNRKEWKAL---------------ADEYEAKVKALEEKEE 826
           ++ ++   H +   + D L++NR+ +++                 D ++ ++  LEE EE
Sbjct: 503 WETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFEL-TLEEAEE 561

Query: 827 EERVAAKKGTE 837
           E+    ++G E
Sbjct: 562 EDEEEEEEGEE 572


>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
          Length = 680

 Score =  137 bits (345), Expect = 4e-32
 Identities = 106/371 (28%), Positives = 187/371 (50%), Gaps = 30/371 (8%)

Query: 487 EILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFS 546
           E L +EL     + +  F  ++L      L      ++ E  +++ FQIP + L  +L  
Sbjct: 286 EQLAKELEDTNKWGLDVFKVAELSGNR-PLTAIIFSIFQERDLLKTFQIPADTLATYLLM 344

Query: 547 ISKGYR-RITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTN 605
           +   Y   + YHN  H  +VAQ+   LL T  L++ +TDLE  A + A   HD+DH G +
Sbjct: 345 LEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVS 404

Query: 606 NLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAI 664
           N + + + + LA ++  +S+LE HHL  G  LL  E  +I+QNL+ +Q   +  ++   +
Sbjct: 405 NQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMV 464

Query: 665 IATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTAC-DLSAIT 723
           +ATD++ +    A  + +V+       K + +  L L+     I +   +  C DLS  T
Sbjct: 465 LATDMSKHMNLLADLKTMVETK-----KVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPT 519

Query: 724 KPWEVQSKVALLVAAEFWEQGDLER-TVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFV 782
           KP  +  +    + AEF++QGD ER + LD    PM D++  A + K QVGFID++   +
Sbjct: 520 KPLPLYRQWTDRIMAEFFQQGDRERESGLDIS--PMCDKH-TASVEKSQVGFIDYIAHPL 576

Query: 783 YKEFSRF-HEEILPMFDRLQNNRKEWKAL---------------ADEYEAKVKALEEKEE 826
           ++ ++   H +   + D L++NR+ +++                 D ++ ++  LEE EE
Sbjct: 577 WETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFEL-TLEEAEE 635

Query: 827 EERVAAKKGTE 837
           E+    ++G E
Sbjct: 636 EDEEEEEEGEE 646


>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
          Length = 712

 Score =  137 bits (345), Expect = 4e-32
 Identities = 106/371 (28%), Positives = 187/371 (50%), Gaps = 30/371 (8%)

Query: 487 EILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFS 546
           E L +EL     + +  F  ++L      L      ++ E  +++ FQIP + L  +L  
Sbjct: 318 EQLAKELEDTNKWGLDVFKVAELSGNR-PLTAIIFSIFQERDLLKTFQIPADTLATYLLM 376

Query: 547 ISKGYR-RITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTN 605
           +   Y   + YHN  H  +VAQ+   LL T  L++ +TDLE  A + A   HD+DH G +
Sbjct: 377 LEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVS 436

Query: 606 NLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAI 664
           N + + + + LA ++  +S+LE HHL  G  LL  E  +I+QNL+ +Q   +  ++   +
Sbjct: 437 NQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMV 496

Query: 665 IATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTAC-DLSAIT 723
           +ATD++ +    A  + +V+       K + +  L L+     I +   +  C DLS  T
Sbjct: 497 LATDMSKHMNLLADLKTMVETK-----KVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPT 551

Query: 724 KPWEVQSKVALLVAAEFWEQGDLER-TVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFV 782
           KP  +  +    + AEF++QGD ER + LD    PM D++  A + K QVGFID++   +
Sbjct: 552 KPLPLYRQWTDRIMAEFFQQGDRERESGLDIS--PMCDKH-TASVEKSQVGFIDYIAHPL 608

Query: 783 YKEFSRF-HEEILPMFDRLQNNRKEWKAL---------------ADEYEAKVKALEEKEE 826
           ++ ++   H +   + D L++NR+ +++                 D ++ ++  LEE EE
Sbjct: 609 WETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFEL-TLEEAEE 667

Query: 827 EERVAAKKGTE 837
           E+    ++G E
Sbjct: 668 EDEEEEEEGEE 678


>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
          Length = 386

 Score =  134 bits (336), Expect = 5e-31
 Identities = 95/335 (28%), Positives = 175/335 (52%), Gaps = 28/335 (8%)

Query: 515 DLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLM 574
           +++ C   MY++LG+VR F I    L R+LF +   YR   +HN+RH F VAQ M++++ 
Sbjct: 63  EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVW 122

Query: 575 TGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLA-KLHGSSILERHHLEFG 633
              L+  ++  +   ++TA +CHD+DH G NN YQ+ ++  LA + +  S LE HH    
Sbjct: 123 LCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVA 182

Query: 634 KFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKK 693
             +L+E   NI+ N+     + +   M   I+ATD+A +        +I+D   ++++K 
Sbjct: 183 FQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARH-------AEIMD---SFKEKM 232

Query: 694 SWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQ 753
              +Y + E     ++  +++  CD+S   +P EV       +  E++ Q D E++  + 
Sbjct: 233 ENFDYSNEE--HMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKS--EG 288

Query: 754 QPI-PMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALAD 812
            P+ P MDR+K  +    Q+GFI FV   +++  ++    + PM + +   +  W++  D
Sbjct: 289 LPVAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTK----LFPMVEEIM-LQPLWES-RD 341

Query: 813 EYEAKVKALEEKEEEERVAAKKGTEICNGGPAPKS 847
            YE ++K +++  +E     +K T+    G   KS
Sbjct: 342 RYE-ELKRIDDAMKE----LQKKTDSLTSGATEKS 371


>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
          Length = 386

 Score =  134 bits (336), Expect = 5e-31
 Identities = 95/335 (28%), Positives = 175/335 (52%), Gaps = 28/335 (8%)

Query: 515 DLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLM 574
           +++ C   MY++LG+VR F I    L R+LF +   YR   +HN+RH F VAQ M++++ 
Sbjct: 63  EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVW 122

Query: 575 TGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLA-KLHGSSILERHHLEFG 633
              L+  ++  +   ++TA +CHD+DH G NN YQ+ ++  LA + +  S LE HH    
Sbjct: 123 LCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVA 182

Query: 634 KFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKK 693
             +L+E   NI+ N+     + +   M   I+ATD+A +        +I+D   ++++K 
Sbjct: 183 FQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARH-------AEIMD---SFKEKM 232

Query: 694 SWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQ 753
              +Y + E     ++  +++  CD+S   +P EV       +  E++ Q D E++  + 
Sbjct: 233 ENFDYSNEE--HMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKS--EG 288

Query: 754 QPI-PMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALAD 812
            P+ P MDR+K  +    Q+GFI FV   +++  ++    + PM + +   +  W++  D
Sbjct: 289 LPVAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTK----LFPMVEEIM-LQPLWES-RD 341

Query: 813 EYEAKVKALEEKEEEERVAAKKGTEICNGGPAPKS 847
            YE ++K +++  +E     +K T+    G   KS
Sbjct: 342 RYE-ELKRIDDAMKE----LQKKTDSLTSGATEKS 371


>gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]
          Length = 567

 Score =  134 bits (336), Expect = 5e-31
 Identities = 95/335 (28%), Positives = 175/335 (52%), Gaps = 28/335 (8%)

Query: 515 DLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLM 574
           +++ C   MY++LG+VR F I    L R+LF +   YR   +HN+RH F VAQ M++++ 
Sbjct: 244 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVW 303

Query: 575 TGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLA-KLHGSSILERHHLEFG 633
              L+  ++  +   ++TA +CHD+DH G NN YQ+ ++  LA + +  S LE HH    
Sbjct: 304 LCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVA 363

Query: 634 KFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKK 693
             +L+E   NI+ N+     + +   M   I+ATD+A +        +I+D   ++++K 
Sbjct: 364 FQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARH-------AEIMD---SFKEKM 413

Query: 694 SWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQ 753
              +Y + E     ++  +++  CD+S   +P EV       +  E++ Q D E++  + 
Sbjct: 414 ENFDYSNEE--HMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKS--EG 469

Query: 754 QPI-PMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALAD 812
            P+ P MDR+K  +    Q+GFI FV   +++  ++    + PM + +   +  W++  D
Sbjct: 470 LPVAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTK----LFPMVEEIM-LQPLWES-RD 522

Query: 813 EYEAKVKALEEKEEEERVAAKKGTEICNGGPAPKS 847
            YE ++K +++  +E     +K T+    G   KS
Sbjct: 523 RYE-ELKRIDDAMKE----LQKKTDSLTSGATEKS 552


>gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens]
          Length = 552

 Score =  134 bits (336), Expect = 5e-31
 Identities = 95/335 (28%), Positives = 175/335 (52%), Gaps = 28/335 (8%)

Query: 515 DLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLM 574
           +++ C   MY++LG+VR F I    L R+LF +   YR   +HN+RH F VAQ M++++ 
Sbjct: 229 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVW 288

Query: 575 TGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLA-KLHGSSILERHHLEFG 633
              L+  ++  +   ++TA +CHD+DH G NN YQ+ ++  LA + +  S LE HH    
Sbjct: 289 LCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVA 348

Query: 634 KFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKK 693
             +L+E   NI+ N+     + +   M   I+ATD+A +        +I+D   ++++K 
Sbjct: 349 FQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARH-------AEIMD---SFKEKM 398

Query: 694 SWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQ 753
              +Y + E     ++  +++  CD+S   +P EV       +  E++ Q D E++  + 
Sbjct: 399 ENFDYSNEE--HMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKS--EG 454

Query: 754 QPI-PMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALAD 812
            P+ P MDR+K  +    Q+GFI FV   +++  ++    + PM + +   +  W++  D
Sbjct: 455 LPVAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTK----LFPMVEEIM-LQPLWES-RD 507

Query: 813 EYEAKVKALEEKEEEERVAAKKGTEICNGGPAPKS 847
            YE ++K +++  +E     +K T+    G   KS
Sbjct: 508 RYE-ELKRIDDAMKE----LQKKTDSLTSGATEKS 537


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,013,726
Number of Sequences: 37866
Number of extensions: 1427052
Number of successful extensions: 4508
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 4190
Number of HSP's gapped (non-prelim): 113
length of query: 853
length of database: 18,247,518
effective HSP length: 111
effective length of query: 742
effective length of database: 14,044,392
effective search space: 10420938864
effective search space used: 10420938864
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.