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Search of human proteins with 223718019
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens]
(575 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens] 1171 0.0
gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens] 1171 0.0
gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens] 1165 0.0
gi|170650674 phosphodiesterase 6A [Homo sapiens] 923 0.0
gi|157364939 phosphodiesterase 6C [Homo sapiens] 838 0.0
gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens] 326 3e-89
gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens] 326 3e-89
gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens] 326 3e-89
gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens] 326 3e-89
gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens] 312 6e-85
gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens] 312 6e-85
gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens] 312 6e-85
gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens] 249 5e-66
gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens] 249 5e-66
gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens] 249 5e-66
gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens] 223 3e-58
gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens] 223 3e-58
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 142 1e-33
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 142 1e-33
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 141 1e-33
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 141 1e-33
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 141 1e-33
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 141 1e-33
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 136 6e-32
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 136 6e-32
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 136 6e-32
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 132 1e-30
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 132 1e-30
gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens] 132 1e-30
gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens] 132 1e-30
>gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens]
Length = 575
Score = 1171 bits (3029), Expect = 0.0
Identities = 575/575 (100%), Positives = 575/575 (100%)
Query: 1 MTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWA 60
MTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWA
Sbjct: 1 MTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWA 60
Query: 61 LASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVA 120
LASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVA
Sbjct: 61 LASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVA 120
Query: 121 TFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 180
TFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD
Sbjct: 121 TFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 180
Query: 181 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 240
RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC
Sbjct: 181 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 240
Query: 241 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLK 300
GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLK
Sbjct: 241 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLK 300
Query: 301 SYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSE 360
SYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSE
Sbjct: 301 SYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSE 360
Query: 361 ETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYL 420
ETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYL
Sbjct: 361 ETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYL 420
Query: 421 SLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMM 480
SLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMM
Sbjct: 421 SLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMM 480
Query: 481 DRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVK 540
DRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVK
Sbjct: 481 DRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVK 540
Query: 541 ALEEKEEEERVAAKKVGTEICNGGPAPKSSTCCIL 575
ALEEKEEEERVAAKKVGTEICNGGPAPKSSTCCIL
Sbjct: 541 ALEEKEEEERVAAKKVGTEICNGGPAPKSSTCCIL 575
>gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens]
Length = 854
Score = 1171 bits (3029), Expect = 0.0
Identities = 575/575 (100%), Positives = 575/575 (100%)
Query: 1 MTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWA 60
MTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWA
Sbjct: 280 MTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWA 339
Query: 61 LASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVA 120
LASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVA
Sbjct: 340 LASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVA 399
Query: 121 TFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 180
TFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD
Sbjct: 400 TFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 459
Query: 181 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 240
RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC
Sbjct: 460 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 519
Query: 241 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLK 300
GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLK
Sbjct: 520 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLK 579
Query: 301 SYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSE 360
SYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSE
Sbjct: 580 SYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSE 639
Query: 361 ETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYL 420
ETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYL
Sbjct: 640 ETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYL 699
Query: 421 SLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMM 480
SLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMM
Sbjct: 700 SLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMM 759
Query: 481 DRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVK 540
DRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVK
Sbjct: 760 DRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVK 819
Query: 541 ALEEKEEEERVAAKKVGTEICNGGPAPKSSTCCIL 575
ALEEKEEEERVAAKKVGTEICNGGPAPKSSTCCIL
Sbjct: 820 ALEEKEEEERVAAKKVGTEICNGGPAPKSSTCCIL 854
>gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens]
Length = 853
Score = 1165 bits (3013), Expect = 0.0
Identities = 574/575 (99%), Positives = 574/575 (99%), Gaps = 1/575 (0%)
Query: 1 MTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWA 60
MTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWA
Sbjct: 280 MTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWA 339
Query: 61 LASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVA 120
LASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVA
Sbjct: 340 LASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVA 399
Query: 121 TFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 180
TFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD
Sbjct: 400 TFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 459
Query: 181 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 240
RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC
Sbjct: 460 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 519
Query: 241 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLK 300
GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLK
Sbjct: 520 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLK 579
Query: 301 SYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSE 360
SYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSE
Sbjct: 580 SYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSE 639
Query: 361 ETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYL 420
ETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYL
Sbjct: 640 ETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYL 699
Query: 421 SLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMM 480
SLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMM
Sbjct: 700 SLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMM 759
Query: 481 DRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVK 540
DRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVK
Sbjct: 760 DRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVK 819
Query: 541 ALEEKEEEERVAAKKVGTEICNGGPAPKSSTCCIL 575
ALEEKEEEERVAAKK GTEICNGGPAPKSSTCCIL
Sbjct: 820 ALEEKEEEERVAAKK-GTEICNGGPAPKSSTCCIL 853
>gi|170650674 phosphodiesterase 6A [Homo sapiens]
Length = 860
Score = 923 bits (2386), Expect = 0.0
Identities = 446/578 (77%), Positives = 496/578 (85%), Gaps = 4/578 (0%)
Query: 1 MTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWA 60
MTK+KEFFDVW VLMGE PYSGPRTPDGREI FYKVIDYILHGKE+IKVIP P DHWA
Sbjct: 282 MTKQKEFFDVWPVLMGEVPPYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWA 341
Query: 61 LASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVA 120
L SGLP+YVA++G ICNIMNA A++ F FQ+ LD+SGW+IKNVLSMPIVNKKEEIVGVA
Sbjct: 342 LVSGLPAYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVA 401
Query: 121 TFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 180
TFYNRKDGKPFDE DE LMESLTQFLGWSV+N DTY+ MNKLENRKDI QD+V YHVKCD
Sbjct: 402 TFYNRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCD 461
Query: 181 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 240
+EIQ IL TR GKEP +C+E+EL EIL+ ELP ++I +FHFSDL TEL+LVKC
Sbjct: 462 NEEIQKILKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKC 521
Query: 241 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLK 300
GIQMYYEL VV KF IPQE LVRF++S+SKGYR+ITYHNWRHGFNV QTMF+LL+TGKLK
Sbjct: 522 GIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLK 581
Query: 301 SYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSE 360
Y+TDLEA AMVTA CHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGK LL +
Sbjct: 582 RYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRD 641
Query: 361 ETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYL 420
E+LNI+QNLNRRQHEH IH+MDIAIIATDLALYFKKR MFQKIVD+SK Y+ ++ W +Y+
Sbjct: 642 ESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYM 701
Query: 421 SLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMM 480
LE TRKEIVMAMMMTACDLSAITKPWEVQS+VALLVAAEFWEQGDLERTVL Q PIPMM
Sbjct: 702 MLEQTRKEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMM 761
Query: 481 DRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVK 540
DRNKA ELPKLQVGFIDFVCTFVYKEFSRFHEEI PM D + NNRKEWKALADEY+AK+K
Sbjct: 762 DRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMK 821
Query: 541 ALEEKEEEERVAAKKVGTEICNGGPAP----KSSTCCI 574
EEK+++++ A G P+P S +CCI
Sbjct: 822 VQEEKKQKQQSAKSAAAGNQPGGNPSPGGATTSKSCCI 859
Score = 45.1 bits (105), Expect = 2e-04
Identities = 51/190 (26%), Positives = 82/190 (43%), Gaps = 33/190 (17%)
Query: 61 LASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVA 120
L G+ +VA S I N+ N DE F L + + KN+L+ PI+N K+ +V +
Sbjct: 136 LDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTE--YKTKNILASPIMNGKD-VVAII 192
Query: 121 TFYNRKDGKPFDEQD-EVLMESLT----------------------QFLGWSVMNTDTYD 157
N+ DG F ++D E+L++ L Q L WS + ++
Sbjct: 193 MAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQILLWS--GSKVFE 250
Query: 158 KMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGP 217
++ +E + A V + CDR + L+ T+ KE D +GE+ GP
Sbjct: 251 ELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQ---KEFFDVWPVLMGEV--PPYSGP 305
Query: 218 TTFDIYEFHF 227
T D E +F
Sbjct: 306 RTPDGREINF 315
>gi|157364939 phosphodiesterase 6C [Homo sapiens]
Length = 858
Score = 838 bits (2164), Expect = 0.0
Identities = 397/576 (68%), Positives = 481/576 (83%), Gaps = 2/576 (0%)
Query: 1 MTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWA 60
MTKEKEF+D W + +GE +PY GP+TPDGRE+ FYK+IDYILHGKEEIKVIPTP ADHW
Sbjct: 284 MTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWT 343
Query: 61 LASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVA 120
L SGLP+YVAE+GFICN+MNA ADE F FQ+G +D++GW+IKNVLS+PIVNKKE+IVGVA
Sbjct: 344 LISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVA 403
Query: 121 TFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 180
TFYNRKDGKPFDE DE + E+LTQFLGWS++NTDTYDKMNKLENRKDIAQ+M++ K
Sbjct: 404 TFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKAT 463
Query: 181 RDEIQLILPTRARLGKEPAD-CDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVK 239
+EI+ IL + +L + D C+E +L ILKE+LP P + ++YEF FSD TE L+K
Sbjct: 464 PEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIK 523
Query: 240 CGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKL 299
CGI++++E+ VV KF++P EVL R+++++ KGYR +TYHNWRHGFNV QTMFTLLMTG+L
Sbjct: 524 CGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRL 583
Query: 300 KSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLS 359
K YYTDLEAFAM+ A CHDIDHRGTNNLYQMKS +PLA+LHGSSILERHHLE+ K LL
Sbjct: 584 KKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQ 643
Query: 360 EETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEY 419
+E+LNI+QNLN+RQ E VIHL ++AIIATDLALYFKKR MFQKIVD + Q ++ ++Y
Sbjct: 644 DESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKY 703
Query: 420 LSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPM 479
++++ T+KEI+MAMMMTACDLSAITKPWEVQS+VAL+VA EFWEQGDLERTVL QQPIPM
Sbjct: 704 VTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPM 763
Query: 480 MDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKV 539
MDRNK ELPKLQVGFIDFVCTFVYKEFSRFH+EI PM LQNNR EWK+LADEY+AK+
Sbjct: 764 MDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKM 823
Query: 540 KALEEKEEEERVAAKKVGTEICNGGPAPKSSTCCIL 575
K +EE+ +++ A+K E GG KS TC +L
Sbjct: 824 KVIEEEAKKQEGGAEK-AAEDSGGGDDKKSKTCLML 858
Score = 37.0 bits (84), Expect = 0.049
Identities = 52/227 (22%), Positives = 93/227 (40%), Gaps = 35/227 (15%)
Query: 25 RTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNASAD 84
R+ +G V +++D K E ++ + L G+ + A + N+ + +
Sbjct: 102 RSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKN 161
Query: 85 EMFK-FQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMESL- 142
F F + +G++ KN+L+ PIV K E++ V N+ + F +QDE +
Sbjct: 162 SHFSDFMD---KQTGYVTKNLLATPIVVGK-EVLAVIMAVNKVNASEFSKQDEEVFSKYL 217
Query: 143 ----------------------TQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 180
+Q L WS ++++ +E + A V ++ C+
Sbjct: 218 NFVSIILRLHHTSYMYNIESRRSQILMWSA--NKVFEELTDVERQFHKALYTVRSYLNCE 275
Query: 181 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHF 227
R I L+ T+ KE D +LGE+ E GP T D E +F
Sbjct: 276 RYSIGLLDMTKE---KEFYDEWPIKLGEV--EPYKGPKTPDGREVNF 317
>gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens]
Length = 575
Score = 326 bits (836), Expect = 3e-89
Identities = 175/478 (36%), Positives = 266/478 (55%), Gaps = 35/478 (7%)
Query: 55 SADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKE 114
S W + + + VA +G NI +A D F + + SG+ I++VL +PI N
Sbjct: 107 SYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNSNH 164
Query: 115 EIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVL 174
+I+GVA NR DGKPFD+ D+ L E+ F G + NT YD++ K ++ +A D++
Sbjct: 165 QIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLS 224
Query: 175 YHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTE 234
YH C + E+ L E A I + HF D
Sbjct: 225 YHATCSKAEVDKFKAANIPLVSELA----------------------IDDIHFDDFSLDV 262
Query: 235 LDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLL 294
++ ++M+ ELG+V+KF+I E L R+L ++ K YR + YHNWRH FNV Q MF +L
Sbjct: 263 DAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAML 322
Query: 295 MTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEF 353
T + T++E A++ LCHD+DHRGTNN +Q KS + LA+L+G S+ LE HH
Sbjct: 323 TTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNH 382
Query: 354 GKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDK 413
+L E NI+ NL+ +++ ++ L+ +I+ATDL LYF++R F ++V +
Sbjct: 383 AVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKG------ 436
Query: 414 KSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLD 473
EY ++I +M+MTACDL A+TKPWE+ +VA LV +EF+EQGD ER L
Sbjct: 437 ----EYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELK 492
Query: 474 QQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKAL 531
P + DRN+ ELP+LQ+ +ID +C +Y+ + + ++ PM D + NR +W+ L
Sbjct: 493 LTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL 550
>gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens]
Length = 683
Score = 326 bits (836), Expect = 3e-89
Identities = 175/478 (36%), Positives = 266/478 (55%), Gaps = 35/478 (7%)
Query: 55 SADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKE 114
S W + + + VA +G NI +A D F + + SG+ I++VL +PI N
Sbjct: 215 SYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNSNH 272
Query: 115 EIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVL 174
+I+GVA NR DGKPFD+ D+ L E+ F G + NT YD++ K ++ +A D++
Sbjct: 273 QIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLS 332
Query: 175 YHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTE 234
YH C + E+ L E A I + HF D
Sbjct: 333 YHATCSKAEVDKFKAANIPLVSELA----------------------IDDIHFDDFSLDV 370
Query: 235 LDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLL 294
++ ++M+ ELG+V+KF+I E L R+L ++ K YR + YHNWRH FNV Q MF +L
Sbjct: 371 DAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAML 430
Query: 295 MTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEF 353
T + T++E A++ LCHD+DHRGTNN +Q KS + LA+L+G S+ LE HH
Sbjct: 431 TTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNH 490
Query: 354 GKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDK 413
+L E NI+ NL+ +++ ++ L+ +I+ATDL LYF++R F ++V +
Sbjct: 491 AVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKG------ 544
Query: 414 KSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLD 473
EY ++I +M+MTACDL A+TKPWE+ +VA LV +EF+EQGD ER L
Sbjct: 545 ----EYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELK 600
Query: 474 QQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKAL 531
P + DRN+ ELP+LQ+ +ID +C +Y+ + + ++ PM D + NR +W+ L
Sbjct: 601 LTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL 658
Score = 46.2 bits (108), Expect = 8e-05
Identities = 36/140 (25%), Positives = 63/140 (45%), Gaps = 8/140 (5%)
Query: 97 SGWLIKNVLSMPIVNKKEEIVGVATFYNR-KDGKPFDEQDEVLMESLTQFLGWSVMNTDT 155
+G+ K++L MPI + EI+GVA N+ +G PF E DE +M+ F G ++ N
Sbjct: 66 TGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQL 125
Query: 156 YDKMNKLENRKDIAQDMV--LYHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEE 213
+ K R ++V L+ + D ++I + RA+ + C +L E+
Sbjct: 126 FAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERC-----SVLLLED 180
Query: 214 LPGPTTFDIYEFHFSDLECT 233
+ P F +C+
Sbjct: 181 IESPVVKFTKSFELMSPKCS 200
>gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens]
Length = 489
Score = 326 bits (836), Expect = 3e-89
Identities = 175/478 (36%), Positives = 266/478 (55%), Gaps = 35/478 (7%)
Query: 55 SADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKE 114
S W + + + VA +G NI +A D F + + SG+ I++VL +PI N
Sbjct: 21 SYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNSNH 78
Query: 115 EIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVL 174
+I+GVA NR DGKPFD+ D+ L E+ F G + NT YD++ K ++ +A D++
Sbjct: 79 QIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLS 138
Query: 175 YHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTE 234
YH C + E+ L E A I + HF D
Sbjct: 139 YHATCSKAEVDKFKAANIPLVSELA----------------------IDDIHFDDFSLDV 176
Query: 235 LDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLL 294
++ ++M+ ELG+V+KF+I E L R+L ++ K YR + YHNWRH FNV Q MF +L
Sbjct: 177 DAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAML 236
Query: 295 MTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEF 353
T + T++E A++ LCHD+DHRGTNN +Q KS + LA+L+G S+ LE HH
Sbjct: 237 TTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNH 296
Query: 354 GKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDK 413
+L E NI+ NL+ +++ ++ L+ +I+ATDL LYF++R F ++V +
Sbjct: 297 AVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKG------ 350
Query: 414 KSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLD 473
EY ++I +M+MTACDL A+TKPWE+ +VA LV +EF+EQGD ER L
Sbjct: 351 ----EYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELK 406
Query: 474 QQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKAL 531
P + DRN+ ELP+LQ+ +ID +C +Y+ + + ++ PM D + NR +W+ L
Sbjct: 407 LTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL 464
>gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens]
Length = 933
Score = 326 bits (836), Expect = 3e-89
Identities = 175/478 (36%), Positives = 266/478 (55%), Gaps = 35/478 (7%)
Query: 55 SADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKE 114
S W + + + VA +G NI +A D F + + SG+ I++VL +PI N
Sbjct: 465 SYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNSNH 522
Query: 115 EIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVL 174
+I+GVA NR DGKPFD+ D+ L E+ F G + NT YD++ K ++ +A D++
Sbjct: 523 QIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLS 582
Query: 175 YHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTE 234
YH C + E+ L E A I + HF D
Sbjct: 583 YHATCSKAEVDKFKAANIPLVSELA----------------------IDDIHFDDFSLDV 620
Query: 235 LDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLL 294
++ ++M+ ELG+V+KF+I E L R+L ++ K YR + YHNWRH FNV Q MF +L
Sbjct: 621 DAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAML 680
Query: 295 MTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEF 353
T + T++E A++ LCHD+DHRGTNN +Q KS + LA+L+G S+ LE HH
Sbjct: 681 TTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNH 740
Query: 354 GKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDK 413
+L E NI+ NL+ +++ ++ L+ +I+ATDL LYF++R F ++V +
Sbjct: 741 AVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKG------ 794
Query: 414 KSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLD 473
EY ++I +M+MTACDL A+TKPWE+ +VA LV +EF+EQGD ER L
Sbjct: 795 ----EYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELK 850
Query: 474 QQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKAL 531
P + DRN+ ELP+LQ+ +ID +C +Y+ + + ++ PM D + NR +W+ L
Sbjct: 851 LTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL 908
Score = 56.6 bits (135), Expect = 6e-08
Identities = 47/173 (27%), Positives = 77/173 (44%), Gaps = 10/173 (5%)
Query: 64 GLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFY 123
G+ YV E G NI +A D F + L +G+ K++L MPI + EI+GVA
Sbjct: 285 GIIGYVGEHGETVNIPDAYQDRRFNDEIDKL--TGYKTKSLLCMPIRSSDGEIIGVAQAI 342
Query: 124 NR-KDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMV--LYHVKCD 180
N+ +G PF E DE +M+ F G ++ N + K R ++V L+ + D
Sbjct: 343 NKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTD 402
Query: 181 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECT 233
++I + RA+ + C +L E++ P F +C+
Sbjct: 403 LEKIVKKIMHRAQTLLKCERC-----SVLLLEDIESPVVKFTKSFELMSPKCS 450
>gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens]
Length = 875
Score = 312 bits (799), Expect = 6e-85
Identities = 169/478 (35%), Positives = 274/478 (57%), Gaps = 39/478 (8%)
Query: 68 YVAESGFICNIMNASADEMFKFQ-EGALDDSGWLIKNVLSMPIVN-KKEEIVGVATFYNR 125
YV + NI + S D+ F + E + + I+++L PI N KK +++GV N+
Sbjct: 414 YVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNK 473
Query: 126 KDG-----KPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 180
+ KPF+ DE +E+ F G + NT Y+ + + ++ + +++ YH
Sbjct: 474 MEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAA 533
Query: 181 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 240
+E + EL + +P T I +F FSD E ++L+ C
Sbjct: 534 EEETR-------------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALC 574
Query: 241 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKL 299
I+M+ +L +V+ FQ+ EVL R++ S+ K YR+ + YHNWRH FN AQ MF L GK+
Sbjct: 575 TIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKI 634
Query: 300 KSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLS 359
++ TDLE A++ A L HD+DHRG NN Y +S++PLA+L+ SI+E HH + +L+
Sbjct: 635 QNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILN 694
Query: 360 EETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESK-NYQDKKSWVE 418
I L+ +++ + ++ AI+ATDLALY K+R F +++ +++ N +D
Sbjct: 695 SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPH---- 750
Query: 419 YLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIP 478
+KE+ +AM+MTACDLSAITKPW +Q ++A LVA EF++QGD ER L+ +P
Sbjct: 751 -------QKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTD 803
Query: 479 MMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYE 536
+M+R K ++P +QVGFID +C +Y+ + E+ P+ D + NR++W+ALA++ E
Sbjct: 804 LMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 861
Score = 52.0 bits (123), Expect = 1e-06
Identities = 35/106 (33%), Positives = 56/106 (52%), Gaps = 5/106 (4%)
Query: 64 GLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFY 123
G+ +VA G NI +A D F + + +G+ +++L MPI N +EE+VGVA
Sbjct: 228 GIVGHVAALGEPLNIKDAYEDPRFNAEVDQI--TGYKTQSILCMPIKNHREEVVGVAQAI 285
Query: 124 NRKDGK--PFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKD 167
N+K G F E+DE + F G + N Y+ + LEN+++
Sbjct: 286 NKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYE-TSLLENKRN 330
>gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens]
Length = 823
Score = 312 bits (799), Expect = 6e-85
Identities = 169/478 (35%), Positives = 274/478 (57%), Gaps = 39/478 (8%)
Query: 68 YVAESGFICNIMNASADEMFKFQ-EGALDDSGWLIKNVLSMPIVN-KKEEIVGVATFYNR 125
YV + NI + S D+ F + E + + I+++L PI N KK +++GV N+
Sbjct: 362 YVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNK 421
Query: 126 KDG-----KPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 180
+ KPF+ DE +E+ F G + NT Y+ + + ++ + +++ YH
Sbjct: 422 MEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAA 481
Query: 181 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 240
+E + EL + +P T I +F FSD E ++L+ C
Sbjct: 482 EEETR-------------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALC 522
Query: 241 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKL 299
I+M+ +L +V+ FQ+ EVL R++ S+ K YR+ + YHNWRH FN AQ MF L GK+
Sbjct: 523 TIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKI 582
Query: 300 KSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLS 359
++ TDLE A++ A L HD+DHRG NN Y +S++PLA+L+ SI+E HH + +L+
Sbjct: 583 QNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILN 642
Query: 360 EETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESK-NYQDKKSWVE 418
I L+ +++ + ++ AI+ATDLALY K+R F +++ +++ N +D
Sbjct: 643 SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPH---- 698
Query: 419 YLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIP 478
+KE+ +AM+MTACDLSAITKPW +Q ++A LVA EF++QGD ER L+ +P
Sbjct: 699 -------QKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTD 751
Query: 479 MMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYE 536
+M+R K ++P +QVGFID +C +Y+ + E+ P+ D + NR++W+ALA++ E
Sbjct: 752 LMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 809
Score = 52.0 bits (123), Expect = 1e-06
Identities = 35/106 (33%), Positives = 56/106 (52%), Gaps = 5/106 (4%)
Query: 64 GLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFY 123
G+ +VA G NI +A D F + + +G+ +++L MPI N +EE+VGVA
Sbjct: 176 GIVGHVAALGEPLNIKDAYEDPRFNAEVDQI--TGYKTQSILCMPIKNHREEVVGVAQAI 233
Query: 124 NRKDGK--PFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKD 167
N+K G F E+DE + F G + N Y+ + LEN+++
Sbjct: 234 NKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYE-TSLLENKRN 278
>gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens]
Length = 833
Score = 312 bits (799), Expect = 6e-85
Identities = 169/478 (35%), Positives = 274/478 (57%), Gaps = 39/478 (8%)
Query: 68 YVAESGFICNIMNASADEMFKFQ-EGALDDSGWLIKNVLSMPIVN-KKEEIVGVATFYNR 125
YV + NI + S D+ F + E + + I+++L PI N KK +++GV N+
Sbjct: 372 YVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNK 431
Query: 126 KDG-----KPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 180
+ KPF+ DE +E+ F G + NT Y+ + + ++ + +++ YH
Sbjct: 432 MEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAA 491
Query: 181 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 240
+E + EL + +P T I +F FSD E ++L+ C
Sbjct: 492 EEETR-------------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALC 532
Query: 241 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKL 299
I+M+ +L +V+ FQ+ EVL R++ S+ K YR+ + YHNWRH FN AQ MF L GK+
Sbjct: 533 TIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKI 592
Query: 300 KSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLS 359
++ TDLE A++ A L HD+DHRG NN Y +S++PLA+L+ SI+E HH + +L+
Sbjct: 593 QNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILN 652
Query: 360 EETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESK-NYQDKKSWVE 418
I L+ +++ + ++ AI+ATDLALY K+R F +++ +++ N +D
Sbjct: 653 SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPH---- 708
Query: 419 YLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIP 478
+KE+ +AM+MTACDLSAITKPW +Q ++A LVA EF++QGD ER L+ +P
Sbjct: 709 -------QKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTD 761
Query: 479 MMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYE 536
+M+R K ++P +QVGFID +C +Y+ + E+ P+ D + NR++W+ALA++ E
Sbjct: 762 LMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 819
Score = 52.0 bits (123), Expect = 1e-06
Identities = 35/106 (33%), Positives = 56/106 (52%), Gaps = 5/106 (4%)
Query: 64 GLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFY 123
G+ +VA G NI +A D F + + +G+ +++L MPI N +EE+VGVA
Sbjct: 186 GIVGHVAALGEPLNIKDAYEDPRFNAEVDQI--TGYKTQSILCMPIKNHREEVVGVAQAI 243
Query: 124 NRKDGK--PFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKD 167
N+K G F E+DE + F G + N Y+ + LEN+++
Sbjct: 244 NKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYE-TSLLENKRN 288
>gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens]
Length = 932
Score = 249 bits (636), Expect = 5e-66
Identities = 142/474 (29%), Positives = 251/474 (52%), Gaps = 37/474 (7%)
Query: 64 GLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFY 123
G+ +VA +G I NI +A A +F G D +G+ +N+L PI N+ +E++GVA
Sbjct: 455 GIAGHVATTGQILNIPDAYAHPLF--YRGVDDSTGFRTRNILCFPIKNENQEVIGVAELV 512
Query: 124 NRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDE 183
N+ +G F + DE L + + + G S+ ++ Y K+N+ + R +A +M++YH+K DE
Sbjct: 513 NKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDE 572
Query: 184 IQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQ 243
+L G +P + F ++ E D +
Sbjct: 573 YTKLLHD----GIQPVAAIDSNFAS----------------FTYTPRSLPEDDTSMAILS 612
Query: 244 MYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYY 303
M ++ + ++I L RF + KGYR YHNW H F+V+ + L +L +Y
Sbjct: 613 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 672
Query: 304 TDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGS--SILERHHLEFGKFLLSEE 361
D+E FA+ + +CHD+DHRGTNN +Q+ S++ LA L+ S S++ERHH +L+
Sbjct: 673 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 732
Query: 362 TLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLS 421
NI+ + +R+ ++ ++ LM I+ATDLA + + QK+ + + +K+
Sbjct: 733 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQ------- 785
Query: 422 LETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMD 481
+++ ++MT+CDLS TK W+ K+A L+ EF+ QGDLE+ + +P+ MMD
Sbjct: 786 ----HHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMD 840
Query: 482 RNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEY 535
R K A +P+LQ+ F++ + +YK + +++R+ +NR+ W ++ ++
Sbjct: 841 REK-AYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKF 893
Score = 31.2 bits (69), Expect = 2.7
Identities = 14/67 (20%), Positives = 39/67 (58%), Gaps = 1/67 (1%)
Query: 98 GWLIKNVLSMPIVNKK-EEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTY 156
G ++ +L +P++++ +++V +A +N+ +G F ++DE +++ + + +T +
Sbjct: 315 GCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAF 374
Query: 157 DKMNKLE 163
K KL+
Sbjct: 375 QKEQKLK 381
>gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens]
Length = 934
Score = 249 bits (636), Expect = 5e-66
Identities = 142/474 (29%), Positives = 251/474 (52%), Gaps = 37/474 (7%)
Query: 64 GLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFY 123
G+ +VA +G I NI +A A +F G D +G+ +N+L PI N+ +E++GVA
Sbjct: 457 GIAGHVATTGQILNIPDAYAHPLF--YRGVDDSTGFRTRNILCFPIKNENQEVIGVAELV 514
Query: 124 NRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDE 183
N+ +G F + DE L + + + G S+ ++ Y K+N+ + R +A +M++YH+K DE
Sbjct: 515 NKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDE 574
Query: 184 IQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQ 243
+L G +P + F ++ E D +
Sbjct: 575 YTKLLHD----GIQPVAAIDSNFAS----------------FTYTPRSLPEDDTSMAILS 614
Query: 244 MYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYY 303
M ++ + ++I L RF + KGYR YHNW H F+V+ + L +L +Y
Sbjct: 615 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 674
Query: 304 TDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGS--SILERHHLEFGKFLLSEE 361
D+E FA+ + +CHD+DHRGTNN +Q+ S++ LA L+ S S++ERHH +L+
Sbjct: 675 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 734
Query: 362 TLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLS 421
NI+ + +R+ ++ ++ LM I+ATDLA + + QK+ + + +K+
Sbjct: 735 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQ------- 787
Query: 422 LETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMD 481
+++ ++MT+CDLS TK W+ K+A L+ EF+ QGDLE+ + +P+ MMD
Sbjct: 788 ----HHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMD 842
Query: 482 RNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEY 535
R K A +P+LQ+ F++ + +YK + +++R+ +NR+ W ++ ++
Sbjct: 843 REK-AYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKF 895
Score = 31.2 bits (69), Expect = 2.7
Identities = 14/67 (20%), Positives = 39/67 (58%), Gaps = 1/67 (1%)
Query: 98 GWLIKNVLSMPIVNKK-EEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTY 156
G ++ +L +P++++ +++V +A +N+ +G F ++DE +++ + + +T +
Sbjct: 317 GCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAF 376
Query: 157 DKMNKLE 163
K KL+
Sbjct: 377 QKEQKLK 383
>gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens]
Length = 941
Score = 249 bits (636), Expect = 5e-66
Identities = 142/474 (29%), Positives = 251/474 (52%), Gaps = 37/474 (7%)
Query: 64 GLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFY 123
G+ +VA +G I NI +A A +F G D +G+ +N+L PI N+ +E++GVA
Sbjct: 464 GIAGHVATTGQILNIPDAYAHPLF--YRGVDDSTGFRTRNILCFPIKNENQEVIGVAELV 521
Query: 124 NRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDE 183
N+ +G F + DE L + + + G S+ ++ Y K+N+ + R +A +M++YH+K DE
Sbjct: 522 NKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDE 581
Query: 184 IQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQ 243
+L G +P + F ++ E D +
Sbjct: 582 YTKLLHD----GIQPVAAIDSNFAS----------------FTYTPRSLPEDDTSMAILS 621
Query: 244 MYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYY 303
M ++ + ++I L RF + KGYR YHNW H F+V+ + L +L +Y
Sbjct: 622 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 681
Query: 304 TDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGS--SILERHHLEFGKFLLSEE 361
D+E FA+ + +CHD+DHRGTNN +Q+ S++ LA L+ S S++ERHH +L+
Sbjct: 682 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 741
Query: 362 TLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLS 421
NI+ + +R+ ++ ++ LM I+ATDLA + + QK+ + + +K+
Sbjct: 742 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQ------- 794
Query: 422 LETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMD 481
+++ ++MT+CDLS TK W+ K+A L+ EF+ QGDLE+ + +P+ MMD
Sbjct: 795 ----HHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMD 849
Query: 482 RNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEY 535
R K A +P+LQ+ F++ + +YK + +++R+ +NR+ W ++ ++
Sbjct: 850 REK-AYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKF 902
Score = 31.2 bits (69), Expect = 2.7
Identities = 14/67 (20%), Positives = 39/67 (58%), Gaps = 1/67 (1%)
Query: 98 GWLIKNVLSMPIVNKK-EEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTY 156
G ++ +L +P++++ +++V +A +N+ +G F ++DE +++ + + +T +
Sbjct: 324 GCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAF 383
Query: 157 DKMNKLE 163
K KL+
Sbjct: 384 QKEQKLK 390
>gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens]
Length = 779
Score = 223 bits (569), Expect = 3e-58
Identities = 155/491 (31%), Positives = 237/491 (48%), Gaps = 53/491 (10%)
Query: 45 KEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNV 104
KE V +++ G+ VA +G + NI +A AD F + +G+ +N+
Sbjct: 310 KEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLY--TGYTTRNI 367
Query: 105 LSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLEN 164
L MPIV++ ++GV N+ G F + DE + F ++ + Y ++ E
Sbjct: 368 LCMPIVSRGS-VIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSEC 426
Query: 165 RKDIAQDMVLYHVKCDRDE----IQLILPTRARLGKEPADCDEDELG--EILKEELPGPT 218
+ + + YH C +E +Q LP R C E EL +I E P
Sbjct: 427 IYRVTMEKLSYHSICTSEEWQGLMQFTLPVRL--------CKEIELFHFDIGPFENMWPG 478
Query: 219 TFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYH 278
F +Y H S CG + EL E L RF+ S+ K YRR+ YH
Sbjct: 479 IF-VYMVHRS-----------CGTSCF-EL----------EKLCRFIMSVKKNYRRVPYH 515
Query: 279 NWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLA 338
NW+H VA M+ +L + +TDLE ++ A LCHD+DHRG +N Y K +PLA
Sbjct: 516 NWKHAVTVAHCMYAILQNNH--TLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLA 573
Query: 339 KLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRA 398
L+ +S +E+HH +L E NI+ L+ ++E V+ ++ AIIATDLALYF R
Sbjct: 574 ALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRK 633
Query: 399 MFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVA 458
+++ + +S ++ V+ +MMTACDL ++TK W V A +
Sbjct: 634 QLEEMYQTGSLNLNNQS----------HRDRVIGLMMTACDLCSVTKLWPVTKLTANDIY 683
Query: 459 AEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMF 518
AEFW +GD E L QPIPMMDR+K E+P+ Q+GF + V Y ++ P+
Sbjct: 684 AEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLL 742
Query: 519 DRLQNNRKEWK 529
++N +W+
Sbjct: 743 KACRDNLSQWE 753
Score = 30.0 bits (66), Expect = 6.0
Identities = 18/57 (31%), Positives = 31/57 (54%), Gaps = 2/57 (3%)
Query: 67 SYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFY 123
+YVA+S + + DE +F G +SG I++VL +PIV +++G+ Y
Sbjct: 153 AYVAKSRKTLLVEDILGDE--RFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELY 207
>gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens]
Length = 789
Score = 223 bits (569), Expect = 3e-58
Identities = 155/491 (31%), Positives = 237/491 (48%), Gaps = 53/491 (10%)
Query: 45 KEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNV 104
KE V +++ G+ VA +G + NI +A AD F + +G+ +N+
Sbjct: 320 KEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLY--TGYTTRNI 377
Query: 105 LSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLEN 164
L MPIV++ ++GV N+ G F + DE + F ++ + Y ++ E
Sbjct: 378 LCMPIVSRGS-VIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSEC 436
Query: 165 RKDIAQDMVLYHVKCDRDE----IQLILPTRARLGKEPADCDEDELG--EILKEELPGPT 218
+ + + YH C +E +Q LP R C E EL +I E P
Sbjct: 437 IYRVTMEKLSYHSICTSEEWQGLMQFTLPVRL--------CKEIELFHFDIGPFENMWPG 488
Query: 219 TFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYH 278
F +Y H S CG + EL E L RF+ S+ K YRR+ YH
Sbjct: 489 IF-VYMVHRS-----------CGTSCF-EL----------EKLCRFIMSVKKNYRRVPYH 525
Query: 279 NWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLA 338
NW+H VA M+ +L + +TDLE ++ A LCHD+DHRG +N Y K +PLA
Sbjct: 526 NWKHAVTVAHCMYAILQNNH--TLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLA 583
Query: 339 KLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRA 398
L+ +S +E+HH +L E NI+ L+ ++E V+ ++ AIIATDLALYF R
Sbjct: 584 ALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRK 643
Query: 399 MFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVA 458
+++ + +S ++ V+ +MMTACDL ++TK W V A +
Sbjct: 644 QLEEMYQTGSLNLNNQS----------HRDRVIGLMMTACDLCSVTKLWPVTKLTANDIY 693
Query: 459 AEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMF 518
AEFW +GD E L QPIPMMDR+K E+P+ Q+GF + V Y ++ P+
Sbjct: 694 AEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLL 752
Query: 519 DRLQNNRKEWK 529
++N +W+
Sbjct: 753 KACRDNLSQWE 763
Score = 30.0 bits (66), Expect = 6.0
Identities = 18/57 (31%), Positives = 31/57 (54%), Gaps = 2/57 (3%)
Query: 67 SYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFY 123
+YVA+S + + DE +F G +SG I++VL +PIV +++G+ Y
Sbjct: 163 AYVAKSRKTLLVEDILGDE--RFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELY 217
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 142 bits (357), Expect = 1e-33
Identities = 98/327 (29%), Positives = 175/327 (53%), Gaps = 11/327 (3%)
Query: 205 ELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRF 264
E ++L +EL + ++ F ++L L ++ E +++ F+IP + L+ +
Sbjct: 389 EQEDVLAKELEDVNKWGLHVFRIAELSGNR-PLTVIMHTIFQERDLLKTFKIPVDTLITY 447
Query: 265 LFSISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHR 323
L ++ Y + YHN H +V Q+ LL T L++ +TDLE A + A HD+DH
Sbjct: 448 LMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHP 507
Query: 324 GTNNLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMD 382
G +N + + + + LA ++ SS+LE HHL G LL EE +I+QNL ++Q + + ++
Sbjct: 508 GVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVI 567
Query: 383 IAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSA 442
++ATD++ + A + +V+ K S V L + R +++ M+ A DLS
Sbjct: 568 DIVLATDMSKHMNLLADLKTMVETKK---VTSSGVLLLDNYSDRIQVLQNMVHCA-DLSN 623
Query: 443 ITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTF 502
TKP ++ + + EF+ QGD ER + PM D++ A+ + K QVGFID++
Sbjct: 624 PTKPLQLYRQWTDRIMEEFFRQGDRERE-RGMEISPMCDKHNAS-VEKSQVGFIDYIVHP 681
Query: 503 VYKEFSRF-HEEILPMFDRLQNNRKEW 528
+++ ++ H + + D L++NR EW
Sbjct: 682 LWETWADLVHPDAQDILDTLEDNR-EW 707
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 142 bits (357), Expect = 1e-33
Identities = 98/327 (29%), Positives = 175/327 (53%), Gaps = 11/327 (3%)
Query: 205 ELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRF 264
E ++L +EL + ++ F ++L L ++ E +++ F+IP + L+ +
Sbjct: 253 EQEDVLAKELEDVNKWGLHVFRIAELSGNR-PLTVIMHTIFQERDLLKTFKIPVDTLITY 311
Query: 265 LFSISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHR 323
L ++ Y + YHN H +V Q+ LL T L++ +TDLE A + A HD+DH
Sbjct: 312 LMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHP 371
Query: 324 GTNNLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMD 382
G +N + + + + LA ++ SS+LE HHL G LL EE +I+QNL ++Q + + ++
Sbjct: 372 GVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVI 431
Query: 383 IAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSA 442
++ATD++ + A + +V+ K S V L + R +++ M+ A DLS
Sbjct: 432 DIVLATDMSKHMNLLADLKTMVETKK---VTSSGVLLLDNYSDRIQVLQNMVHCA-DLSN 487
Query: 443 ITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTF 502
TKP ++ + + EF+ QGD ER + PM D++ A+ + K QVGFID++
Sbjct: 488 PTKPLQLYRQWTDRIMEEFFRQGDRERE-RGMEISPMCDKHNAS-VEKSQVGFIDYIVHP 545
Query: 503 VYKEFSRF-HEEILPMFDRLQNNRKEW 528
+++ ++ H + + D L++NR EW
Sbjct: 546 LWETWADLVHPDAQDILDTLEDNR-EW 571
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 141 bits (356), Expect = 1e-33
Identities = 108/367 (29%), Positives = 188/367 (51%), Gaps = 34/367 (9%)
Query: 208 EILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFS 267
E+L +EL + + F SD L ++ E +++KF+IP + +V ++ +
Sbjct: 302 ELLAQELENLNKWGLNIFCVSDYAGGR-SLTCIMYMIFQERDLLKKFRIPVDTMVTYMLT 360
Query: 268 ISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTN 326
+ Y + YHN H +V Q+ LL T L + +TDLE A + A HD+DH G +
Sbjct: 361 LEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVS 420
Query: 327 NLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAI 385
N + + + + LA ++ S+LE HHL G LL E+ +I+QNL++RQ + + ++ +
Sbjct: 421 NQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMV 480
Query: 386 IATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITK 445
+ATD++ + A + +V+ K S V L + R +++ M+ A DLS TK
Sbjct: 481 LATDMSKHMTLLADLKTMVETKK---VTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 536
Query: 446 PWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYK 505
P E+ + + AEF++QGD ER + PM D++ A + K QVGFID++ +++
Sbjct: 537 PLELYRQWTDRIMAEFFQQGDRERE-RGMEISPMCDKH-TASVEKSQVGFIDYIVHPLWE 594
Query: 506 EFSRF-HEEILPMFDRLQNNRKEW----------------------KALADEYEAKVKAL 542
++ H + + D L++NR +W L D+++ ++ L
Sbjct: 595 TWADLVHPDAQEILDTLEDNR-DWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFEL-TL 652
Query: 543 EEKEEEE 549
EE+EEEE
Sbjct: 653 EEEEEEE 659
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 141 bits (356), Expect = 1e-33
Identities = 108/367 (29%), Positives = 188/367 (51%), Gaps = 34/367 (9%)
Query: 208 EILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFS 267
E+L +EL + + F SD L ++ E +++KF+IP + +V ++ +
Sbjct: 337 ELLAQELENLNKWGLNIFCVSDYAGGR-SLTCIMYMIFQERDLLKKFRIPVDTMVTYMLT 395
Query: 268 ISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTN 326
+ Y + YHN H +V Q+ LL T L + +TDLE A + A HD+DH G +
Sbjct: 396 LEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVS 455
Query: 327 NLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAI 385
N + + + + LA ++ S+LE HHL G LL E+ +I+QNL++RQ + + ++ +
Sbjct: 456 NQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMV 515
Query: 386 IATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITK 445
+ATD++ + A + +V+ K S V L + R +++ M+ A DLS TK
Sbjct: 516 LATDMSKHMTLLADLKTMVETKK---VTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 571
Query: 446 PWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYK 505
P E+ + + AEF++QGD ER + PM D++ A + K QVGFID++ +++
Sbjct: 572 PLELYRQWTDRIMAEFFQQGDRERE-RGMEISPMCDKH-TASVEKSQVGFIDYIVHPLWE 629
Query: 506 EFSRF-HEEILPMFDRLQNNRKEW----------------------KALADEYEAKVKAL 542
++ H + + D L++NR +W L D+++ ++ L
Sbjct: 630 TWADLVHPDAQEILDTLEDNR-DWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFEL-TL 687
Query: 543 EEKEEEE 549
EE+EEEE
Sbjct: 688 EEEEEEE 694
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 141 bits (356), Expect = 1e-33
Identities = 108/367 (29%), Positives = 188/367 (51%), Gaps = 34/367 (9%)
Query: 208 EILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFS 267
E+L +EL + + F SD L ++ E +++KF+IP + +V ++ +
Sbjct: 363 ELLAQELENLNKWGLNIFCVSDYAGGR-SLTCIMYMIFQERDLLKKFRIPVDTMVTYMLT 421
Query: 268 ISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTN 326
+ Y + YHN H +V Q+ LL T L + +TDLE A + A HD+DH G +
Sbjct: 422 LEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVS 481
Query: 327 NLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAI 385
N + + + + LA ++ S+LE HHL G LL E+ +I+QNL++RQ + + ++ +
Sbjct: 482 NQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMV 541
Query: 386 IATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITK 445
+ATD++ + A + +V+ K S V L + R +++ M+ A DLS TK
Sbjct: 542 LATDMSKHMTLLADLKTMVETKK---VTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 597
Query: 446 PWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYK 505
P E+ + + AEF++QGD ER + PM D++ A + K QVGFID++ +++
Sbjct: 598 PLELYRQWTDRIMAEFFQQGDRERE-RGMEISPMCDKH-TASVEKSQVGFIDYIVHPLWE 655
Query: 506 EFSRF-HEEILPMFDRLQNNRKEW----------------------KALADEYEAKVKAL 542
++ H + + D L++NR +W L D+++ ++ L
Sbjct: 656 TWADLVHPDAQEILDTLEDNR-DWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFEL-TL 713
Query: 543 EEKEEEE 549
EE+EEEE
Sbjct: 714 EEEEEEE 720
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 141 bits (356), Expect = 1e-33
Identities = 108/367 (29%), Positives = 188/367 (51%), Gaps = 34/367 (9%)
Query: 208 EILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFS 267
E+L +EL + + F SD L ++ E +++KF+IP + +V ++ +
Sbjct: 124 ELLAQELENLNKWGLNIFCVSDYAGGR-SLTCIMYMIFQERDLLKKFRIPVDTMVTYMLT 182
Query: 268 ISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTN 326
+ Y + YHN H +V Q+ LL T L + +TDLE A + A HD+DH G +
Sbjct: 183 LEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVS 242
Query: 327 NLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAI 385
N + + + + LA ++ S+LE HHL G LL E+ +I+QNL++RQ + + ++ +
Sbjct: 243 NQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMV 302
Query: 386 IATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITK 445
+ATD++ + A + +V+ K S V L + R +++ M+ A DLS TK
Sbjct: 303 LATDMSKHMTLLADLKTMVETKK---VTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 358
Query: 446 PWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYK 505
P E+ + + AEF++QGD ER + PM D++ A + K QVGFID++ +++
Sbjct: 359 PLELYRQWTDRIMAEFFQQGDRERE-RGMEISPMCDKH-TASVEKSQVGFIDYIVHPLWE 416
Query: 506 EFSRF-HEEILPMFDRLQNNRKEW----------------------KALADEYEAKVKAL 542
++ H + + D L++NR +W L D+++ ++ L
Sbjct: 417 TWADLVHPDAQEILDTLEDNR-DWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFEL-TL 474
Query: 543 EEKEEEE 549
EE+EEEE
Sbjct: 475 EEEEEEE 481
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 136 bits (342), Expect = 6e-32
Identities = 106/365 (29%), Positives = 185/365 (50%), Gaps = 33/365 (9%)
Query: 208 EILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFS 267
E L +EL + + F ++L L ++ E +++ FQIP + L +L
Sbjct: 212 EQLAKELEDTNKWGLDVFKVAELSGNR-PLTAIIFSIFQERDLLKTFQIPADTLATYLLM 270
Query: 268 ISKGYR-RITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTN 326
+ Y + YHN H +VAQ+ LL T L++ +TDLE A + A HD+DH G +
Sbjct: 271 LEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVS 330
Query: 327 NLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAI 385
N + + + + LA ++ +S+LE HHL G LL E +I+QNL+ +Q + ++ +
Sbjct: 331 NQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMV 390
Query: 386 IATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTAC-DLSAIT 444
+ATD++ + A + +V+ K + + L L+ I + + C DLS T
Sbjct: 391 LATDMSKHMNLLADLKTMVETK-----KVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPT 445
Query: 445 KPWEVQSKVALLVAAEFWEQGDLER-TVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFV 503
KP + + + AEF++QGD ER + LD PM D++ A + K QVGFID++ +
Sbjct: 446 KPLPLYRQWTDRIMAEFFQQGDRERESGLDIS--PMCDKH-TASVEKSQVGFIDYIAHPL 502
Query: 504 YKEFSRF-HEEILPMFDRLQNNRKEW------KALAD------------EYEAKVKALEE 544
++ ++ H + + D L++NR EW ++ +D ++E ++ EE
Sbjct: 503 WETWADLVHPDAQDLLDTLEDNR-EWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEE 561
Query: 545 KEEEE 549
++EEE
Sbjct: 562 EDEEE 566
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 136 bits (342), Expect = 6e-32
Identities = 106/365 (29%), Positives = 185/365 (50%), Gaps = 33/365 (9%)
Query: 208 EILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFS 267
E L +EL + + F ++L L ++ E +++ FQIP + L +L
Sbjct: 286 EQLAKELEDTNKWGLDVFKVAELSGNR-PLTAIIFSIFQERDLLKTFQIPADTLATYLLM 344
Query: 268 ISKGYR-RITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTN 326
+ Y + YHN H +VAQ+ LL T L++ +TDLE A + A HD+DH G +
Sbjct: 345 LEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVS 404
Query: 327 NLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAI 385
N + + + + LA ++ +S+LE HHL G LL E +I+QNL+ +Q + ++ +
Sbjct: 405 NQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMV 464
Query: 386 IATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTAC-DLSAIT 444
+ATD++ + A + +V+ K + + L L+ I + + C DLS T
Sbjct: 465 LATDMSKHMNLLADLKTMVETK-----KVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPT 519
Query: 445 KPWEVQSKVALLVAAEFWEQGDLER-TVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFV 503
KP + + + AEF++QGD ER + LD PM D++ A + K QVGFID++ +
Sbjct: 520 KPLPLYRQWTDRIMAEFFQQGDRERESGLDIS--PMCDKH-TASVEKSQVGFIDYIAHPL 576
Query: 504 YKEFSRF-HEEILPMFDRLQNNRKEW------KALAD------------EYEAKVKALEE 544
++ ++ H + + D L++NR EW ++ +D ++E ++ EE
Sbjct: 577 WETWADLVHPDAQDLLDTLEDNR-EWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEE 635
Query: 545 KEEEE 549
++EEE
Sbjct: 636 EDEEE 640
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 136 bits (342), Expect = 6e-32
Identities = 106/365 (29%), Positives = 185/365 (50%), Gaps = 33/365 (9%)
Query: 208 EILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFS 267
E L +EL + + F ++L L ++ E +++ FQIP + L +L
Sbjct: 318 EQLAKELEDTNKWGLDVFKVAELSGNR-PLTAIIFSIFQERDLLKTFQIPADTLATYLLM 376
Query: 268 ISKGYR-RITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTN 326
+ Y + YHN H +VAQ+ LL T L++ +TDLE A + A HD+DH G +
Sbjct: 377 LEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVS 436
Query: 327 NLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAI 385
N + + + + LA ++ +S+LE HHL G LL E +I+QNL+ +Q + ++ +
Sbjct: 437 NQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMV 496
Query: 386 IATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTAC-DLSAIT 444
+ATD++ + A + +V+ K + + L L+ I + + C DLS T
Sbjct: 497 LATDMSKHMNLLADLKTMVETK-----KVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPT 551
Query: 445 KPWEVQSKVALLVAAEFWEQGDLER-TVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFV 503
KP + + + AEF++QGD ER + LD PM D++ A + K QVGFID++ +
Sbjct: 552 KPLPLYRQWTDRIMAEFFQQGDRERESGLDIS--PMCDKH-TASVEKSQVGFIDYIAHPL 608
Query: 504 YKEFSRF-HEEILPMFDRLQNNRKEW------KALAD------------EYEAKVKALEE 544
++ ++ H + + D L++NR EW ++ +D ++E ++ EE
Sbjct: 609 WETWADLVHPDAQDLLDTLEDNR-EWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEE 667
Query: 545 KEEEE 549
++EEE
Sbjct: 668 EDEEE 672
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 132 bits (331), Expect = 1e-30
Identities = 92/317 (29%), Positives = 166/317 (52%), Gaps = 23/317 (7%)
Query: 236 DLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLM 295
+++ C MY++LG+VR F I L R+LF + YR +HN+RH F VAQ M++++
Sbjct: 63 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVW 122
Query: 296 TGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLA-KLHGSSILERHHLEFG 354
L+ ++ + ++TA +CHD+DH G NN YQ+ ++ LA + + S LE HH
Sbjct: 123 LCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVA 182
Query: 355 KFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKK 414
+L+E NI+ N+ + + M I+ATD+A + +I+D ++++K
Sbjct: 183 FQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARH-------AEIMD---SFKEKM 232
Query: 415 SWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQ 474
+Y + E ++ +++ CD+S +P EV + E++ Q D E++ +
Sbjct: 233 ENFDYSNEE--HMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKS--EG 288
Query: 475 QPI-PMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFH---EEILPMFDRLQNNRKEWKA 530
P+ P MDR+K + Q+GFI FV +++ ++ EEI M L +R ++
Sbjct: 289 LPVAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEI--MLQPLWESRDRYEE 345
Query: 531 LADEYEAKVKALEEKEE 547
L + +K L++K +
Sbjct: 346 L-KRIDDAMKELQKKTD 361
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 132 bits (331), Expect = 1e-30
Identities = 92/317 (29%), Positives = 166/317 (52%), Gaps = 23/317 (7%)
Query: 236 DLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLM 295
+++ C MY++LG+VR F I L R+LF + YR +HN+RH F VAQ M++++
Sbjct: 63 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVW 122
Query: 296 TGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLA-KLHGSSILERHHLEFG 354
L+ ++ + ++TA +CHD+DH G NN YQ+ ++ LA + + S LE HH
Sbjct: 123 LCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVA 182
Query: 355 KFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKK 414
+L+E NI+ N+ + + M I+ATD+A + +I+D ++++K
Sbjct: 183 FQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARH-------AEIMD---SFKEKM 232
Query: 415 SWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQ 474
+Y + E ++ +++ CD+S +P EV + E++ Q D E++ +
Sbjct: 233 ENFDYSNEE--HMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKS--EG 288
Query: 475 QPI-PMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFH---EEILPMFDRLQNNRKEWKA 530
P+ P MDR+K + Q+GFI FV +++ ++ EEI M L +R ++
Sbjct: 289 LPVAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEI--MLQPLWESRDRYEE 345
Query: 531 LADEYEAKVKALEEKEE 547
L + +K L++K +
Sbjct: 346 L-KRIDDAMKELQKKTD 361
>gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]
Length = 567
Score = 132 bits (331), Expect = 1e-30
Identities = 92/317 (29%), Positives = 166/317 (52%), Gaps = 23/317 (7%)
Query: 236 DLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLM 295
+++ C MY++LG+VR F I L R+LF + YR +HN+RH F VAQ M++++
Sbjct: 244 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVW 303
Query: 296 TGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLA-KLHGSSILERHHLEFG 354
L+ ++ + ++TA +CHD+DH G NN YQ+ ++ LA + + S LE HH
Sbjct: 304 LCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVA 363
Query: 355 KFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKK 414
+L+E NI+ N+ + + M I+ATD+A + +I+D ++++K
Sbjct: 364 FQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARH-------AEIMD---SFKEKM 413
Query: 415 SWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQ 474
+Y + E ++ +++ CD+S +P EV + E++ Q D E++ +
Sbjct: 414 ENFDYSNEE--HMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKS--EG 469
Query: 475 QPI-PMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFH---EEILPMFDRLQNNRKEWKA 530
P+ P MDR+K + Q+GFI FV +++ ++ EEI M L +R ++
Sbjct: 470 LPVAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEI--MLQPLWESRDRYEE 526
Query: 531 LADEYEAKVKALEEKEE 547
L + +K L++K +
Sbjct: 527 L-KRIDDAMKELQKKTD 542
>gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens]
Length = 552
Score = 132 bits (331), Expect = 1e-30
Identities = 92/317 (29%), Positives = 166/317 (52%), Gaps = 23/317 (7%)
Query: 236 DLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLM 295
+++ C MY++LG+VR F I L R+LF + YR +HN+RH F VAQ M++++
Sbjct: 229 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVW 288
Query: 296 TGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLA-KLHGSSILERHHLEFG 354
L+ ++ + ++TA +CHD+DH G NN YQ+ ++ LA + + S LE HH
Sbjct: 289 LCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVA 348
Query: 355 KFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKK 414
+L+E NI+ N+ + + M I+ATD+A + +I+D ++++K
Sbjct: 349 FQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARH-------AEIMD---SFKEKM 398
Query: 415 SWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQ 474
+Y + E ++ +++ CD+S +P EV + E++ Q D E++ +
Sbjct: 399 ENFDYSNEE--HMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKS--EG 454
Query: 475 QPI-PMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFH---EEILPMFDRLQNNRKEWKA 530
P+ P MDR+K + Q+GFI FV +++ ++ EEI M L +R ++
Sbjct: 455 LPVAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEI--MLQPLWESRDRYEE 511
Query: 531 LADEYEAKVKALEEKEE 547
L + +K L++K +
Sbjct: 512 L-KRIDDAMKELQKKTD 527
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,710,124
Number of Sequences: 37866
Number of extensions: 974804
Number of successful extensions: 3302
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 3041
Number of HSP's gapped (non-prelim): 99
length of query: 575
length of database: 18,247,518
effective HSP length: 108
effective length of query: 467
effective length of database: 14,157,990
effective search space: 6611781330
effective search space used: 6611781330
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.