Search of human proteins with 223468705

Search of human proteins with 223468705

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|223468705 5-hydroxytryptamine receptor 3 subunit D isoform 1
[Homo sapiens]
         (404 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|223468705 5-hydroxytryptamine receptor 3 subunit D isoform 1 ...   830   0.0  
gi|47519877 5-hydroxytryptamine receptor 3 subunit D isoform 2 [...   547   e-156
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]   447   e-126
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]   374   e-104
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform...   144   1e-34
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform...   144   1e-34
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform...   144   2e-34
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi...    91   1e-18
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [...    81   2e-15
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor...    77   3e-14
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec...    76   6e-14
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre...    76   6e-14
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [...    70   3e-12
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ...    70   3e-12
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H...    64   2e-10
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec...    63   4e-10
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec...    62   9e-10
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec...    62   1e-09
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]     59   8e-09
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]    58   1e-08
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]    58   2e-08
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]               57   2e-08
gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]               57   2e-08
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr...    57   2e-08
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]      54   3e-07
gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ...    49   6e-06
gi|206725456 zinc activated ligand-gated ion channel [Homo sapiens]    44   3e-04
gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p...    42   0.001
gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta pre...    35   0.12 
gi|88702793 slit-like 2 [Homo sapiens]                                 35   0.12 

>gi|223468705 5-hydroxytryptamine receptor 3 subunit D isoform 1
           [Homo sapiens]
          Length = 404

 Score =  830 bits (2144), Expect = 0.0
 Identities = 404/404 (100%), Positives = 404/404 (100%)

Query: 1   MERGWFHGKGFLLGFILHLLLQDSHLQLVTSFLWLNMWNPDECGGIKKSGMATENLWLSD 60
           MERGWFHGKGFLLGFILHLLLQDSHLQLVTSFLWLNMWNPDECGGIKKSGMATENLWLSD
Sbjct: 1   MERGWFHGKGFLLGFILHLLLQDSHLQLVTSFLWLNMWNPDECGGIKKSGMATENLWLSD 60

Query: 61  VFIEESVDQTPAGLMASMSIVKATSNTISQCGWSASANWTPSISPSMDRGERSPSALSPT 120
           VFIEESVDQTPAGLMASMSIVKATSNTISQCGWSASANWTPSISPSMDRGERSPSALSPT
Sbjct: 61  VFIEESVDQTPAGLMASMSIVKATSNTISQCGWSASANWTPSISPSMDRGERSPSALSPT 120

Query: 121 QVTRAWRRMSRSFQIHHRTSFRTRREWVLLGIQKRTIKVTVATNQYEQAIFHVAIRRRCR 180
           QVTRAWRRMSRSFQIHHRTSFRTRREWVLLGIQKRTIKVTVATNQYEQAIFHVAIRRRCR
Sbjct: 121 QVTRAWRRMSRSFQIHHRTSFRTRREWVLLGIQKRTIKVTVATNQYEQAIFHVAIRRRCR 180

Query: 181 PSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTS 240
           PSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTS
Sbjct: 181 PSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTS 240

Query: 241 SHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLL 300
           SHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLL
Sbjct: 241 SHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLL 300

Query: 301 HCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQRE 360
           HCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQRE
Sbjct: 301 HCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQRE 360

Query: 361 HEAQKQHSVELWVQFSHAMDALLFRLYLLFMASSIITVICLWNT 404
           HEAQKQHSVELWVQFSHAMDALLFRLYLLFMASSIITVICLWNT
Sbjct: 361 HEAQKQHSVELWVQFSHAMDALLFRLYLLFMASSIITVICLWNT 404


>gi|47519877 5-hydroxytryptamine receptor 3 subunit D isoform 2
           [Homo sapiens]
          Length = 279

 Score =  547 bits (1410), Expect = e-156
 Identities = 279/330 (84%), Positives = 279/330 (84%), Gaps = 51/330 (15%)

Query: 75  MASMSIVKATSNTISQCGWSASANWTPSISPSMDRGERSPSALSPTQVTRAWRRMSRSFQ 134
           MASMSIVKATSNTISQCGWSASANWTPSISPSMDRGERSPSALSPTQ             
Sbjct: 1   MASMSIVKATSNTISQCGWSASANWTPSISPSMDRGERSPSALSPTQ------------- 47

Query: 135 IHHRTSFRTRREWVLLGIQKRTIKVTVATNQYEQAIFHVAIRRRCRPSPYVVNFLVPSGI 194
                                                 VAIRRRCRPSPYVVNFLVPSGI
Sbjct: 48  --------------------------------------VAIRRRCRPSPYVVNFLVPSGI 69

Query: 195 LIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQ 254
           LIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQ
Sbjct: 70  LIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQ 129

Query: 255 KRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQ 314
           KRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQ
Sbjct: 130 KRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQ 189

Query: 315 KGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQ 374
           KGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQ
Sbjct: 190 KGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQ 249

Query: 375 FSHAMDALLFRLYLLFMASSIITVICLWNT 404
           FSHAMDALLFRLYLLFMASSIITVICLWNT
Sbjct: 250 FSHAMDALLFRLYLLFMASSIITVICLWNT 279


>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
          Length = 471

 Score =  447 bits (1150), Expect = e-126
 Identities = 248/414 (59%), Positives = 283/414 (68%), Gaps = 47/414 (11%)

Query: 13  LGFILHLLLQ-DSHLQLVTSFLWLNM--------WNPDECGGIKKSGMATENLWLSDVFI 63
           + F +  +L  +  L L++SFLWL M        WNP+EC GI K  MA +NLWL D+FI
Sbjct: 83  ISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMSMAAKNLWLPDIFI 142

Query: 64  EE--SVDQTPAGLMASMSI-----VKATSNTISQCGWSA------SANWTPSISPSMDRG 110
            E   VD+TP GL A +S       K      S C            N T + S  +   
Sbjct: 143 IELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFL--- 199

Query: 111 ERSPSALSPTQVTRAWRRMSRSFQIHHRTSFRTRREWVLLGIQKRTIKVTVATNQYEQAI 170
             +  ++        W     S     R   +T  EW LLG+ K T K++   N Y+Q +
Sbjct: 200 -YTVDSMLLDMEKEVWEITDAS-----RNILQTHGEWELLGLSKATAKLSRGGNLYDQIV 253

Query: 171 FHVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMM 230
           F+VAIRRR  PS YV+N LVPSG L+AIDALSFYLP++SGN  PFK+T+LLGY+VFLLMM
Sbjct: 254 FYVAIRRR--PSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMM 311

Query: 231 NDLLPATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLP 290
           +DLLP + T     L+          GVYFALCLSLMVGSLLETIFITHLLHVATTQP P
Sbjct: 312 SDLLPTSGTP----LI----------GVYFALCLSLMVGSLLETIFITHLLHVATTQPPP 357

Query: 291 LPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTG 350
           LPRWLHSLLLHC   GRCCPTAPQK NKGPGLTPTHLPGVKEPEVSAGQMPGP EAELTG
Sbjct: 358 LPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTG 417

Query: 351 GSEWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLLFMASSIITVICLWNT 404
           GSEWTRAQREHEAQKQHSVELW+QFSHAMDA+LFRLYLLFMASSIITVICLWNT
Sbjct: 418 GSEWTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLYLLFMASSIITVICLWNT 471


>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
          Length = 447

 Score =  374 bits (960), Expect = e-104
 Identities = 221/414 (53%), Positives = 259/414 (62%), Gaps = 56/414 (13%)

Query: 13  LGFILHLLLQ-DSHLQLVTSFLWLNM--------WNPDECGGIKKSGMATENLWLSDVFI 63
           + F L  +L  D+ LQL+TSFLW+++        WNP EC GI K  +  ENLWL D+FI
Sbjct: 68  ISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAENLWLPDIFI 127

Query: 64  EES--VDQTPAGLMASMSI-----VKATSNTISQCGWSA------SANWTPSISPSMDRG 110
            ES  VDQTP+GL A +S              S C            N T + S  +   
Sbjct: 128 VESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTFSSFLYTV 187

Query: 111 ERSPSALSPTQVTRAWRRMSRSFQIHHRTSFRTRREWVLLGIQKRTIKVTVATNQYEQAI 170
           +     +        W     S     R   +T+ EW LLGI K T K+++  N Y+Q +
Sbjct: 188 DSMLLGMDK----EVWEITDTS-----RKVIQTQGEWELLGINKATPKMSMGNNLYDQIM 238

Query: 171 FHVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMM 230
           F+VAIRRR  PS Y++N LVPS  L+AIDALSFYLP ES N APFK+T+LLGY+VFLLMM
Sbjct: 239 FYVAIRRR--PSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMM 296

Query: 231 NDLLPATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLP 290
           NDLLPA+ T   +              VYFALCLSLMV SLLET+FIT+LLHVATTQP P
Sbjct: 297 NDLLPASGTPLIS--------------VYFALCLSLMVVSLLETVFITYLLHVATTQPPP 342

Query: 291 LPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTG 350
           +PRWLHSLLLHCT  GRCCPTAPQKGNKG GLT THLPG KEP   AG+  GP E E  G
Sbjct: 343 MPRWLHSLLLHCTSPGRCCPTAPQKGNKGLGLTLTHLPGPKEPGELAGKKLGPRETEPDG 402

Query: 351 GSEWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLLFMASSIITVICLWNT 404
           GS WT+ Q          +ELWVQFSHAMD LLFRLYLLFMASSI+TVI LWNT
Sbjct: 403 GSGWTKTQ---------LMELWVQFSHAMDTLLFRLYLLFMASSILTVIVLWNT 447


>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
           precursor [Homo sapiens]
          Length = 484

 Score =  144 bits (363), Expect = 1e-34
 Identities = 127/446 (28%), Positives = 201/446 (45%), Gaps = 70/446 (15%)

Query: 3   RGWFHGKGFLLGFILHLLLQ-DSHLQLVTSFLWLNM--------WNPDECGGIKKSGMAT 53
           R W       +  I++ +L  D   Q++T+++W           WNP++   I K  + T
Sbjct: 59  RDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPT 118

Query: 54  ENLWLSDVFIEESVDQTPAGLMASMSIVKATSNTISQCGWSASANWTPS---ISPSMDRG 110
           +++W+ D+ I E VD    G   ++  V        Q       N+ P     + S+D  
Sbjct: 119 DSIWVPDILINEFVD---VGKSPNIPYVYIRHQGEVQ-------NYKPLQVVTACSLDIY 168

Query: 111 ERSPSALSPTQVTRAWRRMSRSFQIH----------HRTSFRTRREWVLLGIQKRTIKVT 160
                  + +    +W    +   I            R+ F  + EW LLG+     + +
Sbjct: 169 NFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFS 228

Query: 161 V-ATNQYEQAIFHVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTV 219
           + ++N Y +  F+V IRRR  P  YVV+ L+PS  L+ +D + FYLP  SG    FK+T+
Sbjct: 229 MESSNYYAEMKFYVVIRRR--PLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITL 286

Query: 220 LLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITH 279
           LLGYSVFL++++D LPAT+  +               GVYF +C++L+V SL ETIFI  
Sbjct: 287 LLGYSVFLIIVSDTLPATAIGTPLI------------GVYFVVCMALLVISLAETIFIVR 334

Query: 280 LLHVATTQPLPLPRWLHSLLLHCTGQGRCC--------PTAPQKGNK-----GPGLTPTH 326
           L+H    Q  P+P WL  L+L       C         P A  +  K       G   +H
Sbjct: 335 LVHKQDLQQ-PVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSH 393

Query: 327 LPG----VKEPEVSAGQMPGPGEAELT--GGSEWTRAQREHEAQKQHSVEL---WVQFSH 377
           + G     K P       P P EA L   G  +   + R+   ++    E+   W++   
Sbjct: 394 MGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGS 453

Query: 378 AMDALLFRLYLLFMASSIITVICLWN 403
            +D LLF +YLL + +  IT++ LW+
Sbjct: 454 VLDKLLFHIYLLAVLAYSITLVMLWS 479


>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
           [Homo sapiens]
          Length = 463

 Score =  144 bits (363), Expect = 1e-34
 Identities = 127/446 (28%), Positives = 201/446 (45%), Gaps = 70/446 (15%)

Query: 3   RGWFHGKGFLLGFILHLLLQ-DSHLQLVTSFLWLNM--------WNPDECGGIKKSGMAT 53
           R W       +  I++ +L  D   Q++T+++W           WNP++   I K  + T
Sbjct: 38  RDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPT 97

Query: 54  ENLWLSDVFIEESVDQTPAGLMASMSIVKATSNTISQCGWSASANWTPS---ISPSMDRG 110
           +++W+ D+ I E VD    G   ++  V        Q       N+ P     + S+D  
Sbjct: 98  DSIWVPDILINEFVD---VGKSPNIPYVYIRHQGEVQ-------NYKPLQVVTACSLDIY 147

Query: 111 ERSPSALSPTQVTRAWRRMSRSFQIH----------HRTSFRTRREWVLLGIQKRTIKVT 160
                  + +    +W    +   I            R+ F  + EW LLG+     + +
Sbjct: 148 NFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFS 207

Query: 161 V-ATNQYEQAIFHVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTV 219
           + ++N Y +  F+V IRRR  P  YVV+ L+PS  L+ +D + FYLP  SG    FK+T+
Sbjct: 208 MESSNYYAEMKFYVVIRRR--PLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITL 265

Query: 220 LLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITH 279
           LLGYSVFL++++D LPAT+  +               GVYF +C++L+V SL ETIFI  
Sbjct: 266 LLGYSVFLIIVSDTLPATAIGTPLI------------GVYFVVCMALLVISLAETIFIVR 313

Query: 280 LLHVATTQPLPLPRWLHSLLLHCTGQGRCC--------PTAPQKGNK-----GPGLTPTH 326
           L+H    Q  P+P WL  L+L       C         P A  +  K       G   +H
Sbjct: 314 LVHKQDLQQ-PVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSH 372

Query: 327 LPG----VKEPEVSAGQMPGPGEAELT--GGSEWTRAQREHEAQKQHSVEL---WVQFSH 377
           + G     K P       P P EA L   G  +   + R+   ++    E+   W++   
Sbjct: 373 MGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGS 432

Query: 378 AMDALLFRLYLLFMASSIITVICLWN 403
            +D LLF +YLL + +  IT++ LW+
Sbjct: 433 VLDKLLFHIYLLAVLAYSITLVMLWS 458


>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
           precursor [Homo sapiens]
          Length = 516

 Score =  144 bits (362), Expect = 2e-34
 Identities = 131/466 (28%), Positives = 205/466 (43%), Gaps = 78/466 (16%)

Query: 3   RGWFHGKGFLLGFILHLLLQ-DSHLQLVTSFLWLNM--------WNPDECGGIKKSGMAT 53
           R W       +  I++ +L  D   Q++T+++W           WNP++   I K  + T
Sbjct: 59  RDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPT 118

Query: 54  ENLWLSDVFIEESVDQTPAGLMASMSIVKATSNTISQCGWSASANWTPS---ISPSMDRG 110
           +++W+ D+ I E VD    G   ++  V        Q       N+ P     + S+D  
Sbjct: 119 DSIWVPDILINEFVD---VGKSPNIPYVYIRHQGEVQ-------NYKPLQVVTACSLDIY 168

Query: 111 ERSPSALSPTQVTRAWRRMSRSFQIH----------HRTSFRTRREWVLLGIQKRTIKVT 160
                  + +    +W    +   I            R+ F  + EW LLG+     + +
Sbjct: 169 NFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFS 228

Query: 161 V-ATNQYEQAIFHVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTV 219
           + ++N Y +  F+V IRRR  P  YVV+ L+PS  L+ +D + FYLP  SG    FK+T+
Sbjct: 229 MESSNYYAEMKFYVVIRRR--PLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITL 286

Query: 220 LLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQK--------------------RGVY 259
           LLGYSVFL++++D LPAT+  +      P  SR Q                      GVY
Sbjct: 287 LLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVY 346

Query: 260 FALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCC--------PT 311
           F +C++L+V SL ETIFI  L+H    Q  P+P WL  L+L       C         P 
Sbjct: 347 FVVCMALLVISLAETIFIVRLVHKQDLQQ-PVPAWLRHLVLERIAWLLCLREQSTSQRPP 405

Query: 312 APQKGNK-----GPGLTPTHLPG----VKEPEVSAGQMPGPGEAELT--GGSEWTRAQRE 360
           A  +  K       G   +H+ G     K P       P P EA L   G  +   + R+
Sbjct: 406 ATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQ 465

Query: 361 HEAQKQHSVEL---WVQFSHAMDALLFRLYLLFMASSIITVICLWN 403
              ++    E+   W++    +D LLF +YLL + +  IT++ LW+
Sbjct: 466 FLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWS 511


>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
           sapiens]
          Length = 450

 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 97/408 (23%), Positives = 164/408 (40%), Gaps = 60/408 (14%)

Query: 23  DSHLQLVTSFLWLNM--------WNPDECGGIKKSGMATENLWLSDVFIEESVDQTPAGL 74
           D   Q++T +LW+          W+P+  GG+    + +  +W  D+ +    D  P G 
Sbjct: 70  DERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPG- 128

Query: 75  MASMSIVKATSNTISQCGWSASANWTPSISPSMDRGERSPSALSPTQ---VTRAWRRMSR 131
            AS ++V      +    W A     P+I+ S  R + +              +W     
Sbjct: 129 SASTNVVLRHDGAVR---WDA-----PAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGH 180

Query: 132 SFQIHHR------TSFRTRREWVLLGI--QKRTIKVTVATNQYEQAIFHVAIRRRCRPSP 183
              +  R        F    EW +LG+  ++R +     +  Y    F + +RRR   + 
Sbjct: 181 QLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRA--AA 238

Query: 184 YVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHA 243
           YV N L+P  ++  +  L+F+LP +SG      +TVLL  +VF L++ + +P   +    
Sbjct: 239 YVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAES---V 295

Query: 244 SLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCT 303
            L+          G Y+   ++++  S   TI I + LH       P+P W  +LLL   
Sbjct: 296 PLI----------GKYYMATMTMVTFSTALTILIMN-LHYCGPSVRPVPAWARALLLGHL 344

Query: 304 GQGRCCPTAPQKGNK-GPGLTPTHLPGVKEPEVSAGQMPGP---------GEAELTGGSE 353
            +G C     ++G   G    P   P  + PE  AG   GP          EA L   + 
Sbjct: 345 ARGLC---VRERGEPCGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVAT 401

Query: 354 WTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLLFMASSIITVICL 401
                R H A  Q   E W + +  MD   F L + F  + +++++ L
Sbjct: 402 IANTFRSHRA-AQRCHEDWKRLARVMDR--FFLAIFFSMALVMSLLVL 446


>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
           [Homo sapiens]
          Length = 458

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 94/400 (23%), Positives = 169/400 (42%), Gaps = 42/400 (10%)

Query: 16  ILHLLLQDSHLQLVTSFLWLNM--------WNPDECGGIKKSGMATENLWLSDVFIEESV 67
           I  L+  D   QL+T+ +WL          WNPD+ GGI    + +E+LWL D+ + E+ 
Sbjct: 62  ISQLVDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENA 121

Query: 68  DQTPAGLMASMSIVKATSNTISQCGWSASANWTPSISPSM-----DRGERSPSALSPTQV 122
           D    G + +  IVK+    +    W+  A++  S +  +     DR   S    S T  
Sbjct: 122 DGRFEGSLMTKVIVKSNGTVV----WTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYD 177

Query: 123 TRAWRRMSRSFQIHHRTSFRTRREWVLLGIQKRTIKVTVATNQYEQAIFHVAIRRRCRPS 182
                 +  +  +  R  F    EW +L  +            Y    +   +RR   P 
Sbjct: 178 GTMVDLILINENVD-RKDFFDNGEWEILNAKGMKGNRRDGVYSYPFITYSFVLRRL--PL 234

Query: 183 PYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSH 242
            Y +  ++P   L  +  L FYLP + G       +VL+  +VFLL++ +++P  S+S  
Sbjct: 235 FYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIP--SSSKV 292

Query: 243 ASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHC 302
             L+          G Y    +  +  S++ T+F+ ++ H +++   P+  W+  L L  
Sbjct: 293 IPLI----------GEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQK 342

Query: 303 TGQGRCCP------TAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTR 356
             +  C        ++P+K    P +    L   K+ ++S G+      A L   ++  R
Sbjct: 343 LPKLLCMKDHVDRYSSPEKEESQPVVKGKVLEKKKQKQLSDGEK--VLVAFLEKAADSIR 400

Query: 357 AQREHEAQKQHSVELWVQFSHAMDALLFRLYL-LFMASSI 395
               H  +K+H +   VQ    +  +L R++L LF+  S+
Sbjct: 401 YISRH-VKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSV 439


>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
           [Homo sapiens]
          Length = 441

 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 97/420 (23%), Positives = 161/420 (38%), Gaps = 59/420 (14%)

Query: 5   WFHGKGFLLGFILHLLLQ-DSHLQLVTSFLWLN--------MWNPDECGGIKKSGMATEN 55
           W       L   +H +L  D+  Q++ + +W           WN      I++  +    
Sbjct: 53  WTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSA 112

Query: 56  LWLSDVFIEESVD-----QTPAGLMASMSIVKATS--NTISQCGWSASANWTPSISPSMD 108
           +W  D+ I E VD       P   + S   ++       +S C     A      + S+ 
Sbjct: 113 IWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLT 172

Query: 109 RGERSPSALSPTQ-VTRAWRRMSRSFQIHHRTSFRTRREWVLLGIQKRTIKVTVATNQYE 167
                 S L   + V  A+ R     Q H + +F    EW LL +      +  +   + 
Sbjct: 173 ----FKSILHTVEDVDLAFLRSPEDIQ-HDKKAFLNDSEWELLSVSSTYSILQSSAGGFA 227

Query: 168 QAIFHVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFL 227
           Q  F+V +RR   P  YVV+ L+PS  L+ +D  SFYLP        FK +VL+GY+VF 
Sbjct: 228 QIQFNVVMRRH--PLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFR 285

Query: 228 LMMNDLLPATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQ 287
           + M++ +P +  S+               G +F +C++ +V SL ++I +   LH     
Sbjct: 286 VNMSNQVPRSVGSTPLI------------GHFFTICMAFLVLSLAKSIVLVKFLHDEQRG 333

Query: 288 PLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGE-- 345
               P      L   T   R  P    +  +           V E  +    +  PG   
Sbjct: 334 GQEQP---FLCLRGDTDADR--PRVEPRAQRAV---------VTESSLYGEHLAQPGTLK 379

Query: 346 ---AELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLLFMASSIITVICLW 402
              ++L   S + + Q + + Q+      W+      D LLF+ YL  +    IT+  LW
Sbjct: 380 EVWSQLQSISNYLQTQDQTDQQEAE----WLVLLSRFDRLLFQSYLFMLGIYTITLCSLW 435


>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
           precursor [Homo sapiens]
          Length = 457

 Score = 75.9 bits (185), Expect = 6e-14
 Identities = 89/420 (21%), Positives = 161/420 (38%), Gaps = 86/420 (20%)

Query: 16  ILHLLLQDSHLQLVTSFLWLNM--------WNPDECGGIKKSGMATENLWLSDVFIEESV 67
           ++ L+  D   Q+VT+ + L          WNPD+ GG+KK  + +E +W  D+ +  + 
Sbjct: 57  LIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNA 116

Query: 68  DQTPAGLMASMSIVKATSNTISQCGWSASANWTPS---------ISPSMDRGERSPSALS 118
           D          +IVK T   +   G      WTP          I       E++ S   
Sbjct: 117 D-------GDFAIVKFTKVLLQYTG---HITWTPPAIFKSYCEIIVTHFPFDEQNCSMKL 166

Query: 119 PTQVTRAWRRMSRSFQIHHRT------SFRTRREWVLLGIQKRTIKVTVAT---NQYEQA 169
            T     W        I+  +      +F    EWV+   +     VT +      Y   
Sbjct: 167 GT-----WTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDI 221

Query: 170 IFHVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLM 229
            +H  ++R   P  ++VN ++P  +   +  L FYLP +SG      ++VLL  +VFLL+
Sbjct: 222 TYHFVMQRL--PLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLV 279

Query: 230 MNDLLPATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPL 289
           + +L+P  STSS   L+          G Y    +  ++ S++ T+ + +  H + +  +
Sbjct: 280 IVELIP--STSSAVPLI----------GKYMLFTMVFVIASIIITVIVINTHHRSPSTHV 327

Query: 290 PLPRWLHSLLLHCTGQGRCCPTAPQ--------------------KGNKGPGLTPTHLPG 329
            +P W+  + +          T  +                     G  GP     H P 
Sbjct: 328 -MPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPL 386

Query: 330 VKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLL 389
           +K PEV +             G ++     + + +  ++   W   +  MD +L  +++L
Sbjct: 387 IKHPEVKSA----------IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFML 436


>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
           precursor [Homo sapiens]
          Length = 482

 Score = 75.9 bits (185), Expect = 6e-14
 Identities = 87/404 (21%), Positives = 154/404 (38%), Gaps = 78/404 (19%)

Query: 24  SHLQLVTSFLWLNMWNPDECGGIKKSGMATENLWLSDVFIEESVDQTPAGLMASMSIVKA 83
           SHLQ      +   WNPD+ GG+KK  + +E +W  D+ +  + D          +IVK 
Sbjct: 98  SHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNAD-------GDFAIVKF 150

Query: 84  TSNTISQCGWSASANWTPS---------ISPSMDRGERSPSALSPTQVTRAWRRMSRSFQ 134
           T   +   G      WTP          I       E++ S    T     W        
Sbjct: 151 TKVLLQYTG---HITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGT-----WTYDGSVVA 202

Query: 135 IHHRT------SFRTRREWVLLGIQKRTIKVTVAT---NQYEQAIFHVAIRRRCRPSPYV 185
           I+  +      +F    EWV+   +     VT +      Y    +H  ++R   P  ++
Sbjct: 203 INPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRL--PLYFI 260

Query: 186 VNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASL 245
           VN ++P  +   +  L FYLP +SG      ++VLL  +VFLL++ +L+P  STSS   L
Sbjct: 261 VNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIP--STSSAVPL 318

Query: 246 VRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQ 305
           +          G Y    +  ++ S++ T+ + +  H + +  + +P W+  + +     
Sbjct: 319 I----------GKYMLFTMVFVIASIIITVIVINTHHRSPSTHV-MPNWVRKVFIDTIPN 367

Query: 306 GRCCPTAPQ--------------------KGNKGPGLTPTHLPGVKEPEVSAGQMPGPGE 345
                T  +                     G  GP     H P +K PEV +        
Sbjct: 368 IMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA------- 420

Query: 346 AELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLL 389
                G ++     + + +  ++   W   +  MD +L  +++L
Sbjct: 421 ---IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFML 461


>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
           [Homo sapiens]
          Length = 479

 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 67/297 (22%), Positives = 125/297 (42%), Gaps = 44/297 (14%)

Query: 23  DSHLQLVTSFLWLNM--------WNPDECGGIKKSGMATENLWLSDVFIEESVDQTPAGL 74
           D   Q++T++LW+          W+ D+  G+    + ++ +W  D+ +    D   +  
Sbjct: 71  DERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEP 130

Query: 75  MASMSIVKATSNTISQCGWSASANWTPSISPSMDRGERSPSALSPTQVTR---AWRRMSR 131
           + + ++V      I+   W A     P+I+ S    + +       Q      +W     
Sbjct: 131 V-NTNVVLRYDGLIT---WDA-----PAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGN 181

Query: 132 SFQIHHR------TSFRTRREWVLLGIQ--KRTIKVTVATNQYEQAIFHVAIRRRCRPSP 183
              I +       + F    EW + G+   K  I     +  Y    F + ++RR   S 
Sbjct: 182 QVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRS--SF 239

Query: 184 YVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHA 243
           Y+VN L+P  ++  +  LSFYLP  SG      +T+LL  +VF LM+ +++PA   S + 
Sbjct: 240 YIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPA---SENV 296

Query: 244 SLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLL 300
            L+          G Y+   ++L+  S   TI + + +H    +  P+P W   ++L
Sbjct: 297 PLI----------GKYYIATMALITASTALTIMVMN-IHFCGAEARPVPHWARVVIL 342


>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
           (neuronal) [Homo sapiens]
          Length = 529

 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 67/301 (22%), Positives = 120/301 (39%), Gaps = 33/301 (10%)

Query: 16  ILHLLLQDSHLQLVTSFLWLNM--------WNPDECGGIKKSGMATENLWLSDVFIEESV 67
           I  L+  D   Q++T+ +WL          WNP + G I    + +E +W+ D+ +  + 
Sbjct: 92  IAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNA 151

Query: 68  DQTPAGLMASMSIVKATSNTISQCGWSASANWTPSISPSMD----RGERSPSALSPTQVT 123
           D    G  A   + KA   +     W   A +  S S  +       +            
Sbjct: 152 D----GEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYD 207

Query: 124 RAWRRMSRSFQIHHRTSFRTRREWVLLGIQK--RTIKVTVATNQYEQAIFHVAIRRRCRP 181
           +A   + +  Q      +    EW ++       + K       Y    +   IRR   P
Sbjct: 208 KAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRL--P 265

Query: 182 SPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSS 241
             Y +N ++P  ++  +  L FYLP + G      ++VLL  +VFLL++ +++P+T    
Sbjct: 266 LFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPST---- 321

Query: 242 HASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLH 301
             SLV P        G Y    +  +  S++ T+F+ + +H  +     +P W+   LL 
Sbjct: 322 --SLVIP------LIGEYLLFTMIFVTLSIVITVFVLN-VHHRSPSTHTMPHWVRGALLG 372

Query: 302 C 302
           C
Sbjct: 373 C 373


>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
           sapiens]
          Length = 502

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 80/352 (22%), Positives = 138/352 (39%), Gaps = 53/352 (15%)

Query: 16  ILHLLLQDSHLQLVTSFLWLNM--------WNPDECGGIKKSGMATENLWLSDVFIEESV 67
           +L ++  D   Q++T+ +WL M        WN  E  G+K        +W  D+ +  S 
Sbjct: 59  LLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSA 118

Query: 68  DQTPAGLMASMSIVKATSNT------ISQCGWSASANWTPSISP--SMDRGERSPSALSP 119
           D+       +  +V ++ +       I +        W P       +  G  S    S 
Sbjct: 119 DERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWS- 177

Query: 120 TQVTRAWRRMSRSFQIHHRTSFRTRREWVLLGIQ-KRTIKVTVATNQ-YEQAIFHVAIRR 177
                    +    Q    + +    EW L+GI  KR+ +      + Y    F V +RR
Sbjct: 178 ---------LDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRR 228

Query: 178 RCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPAT 237
           R     Y +N L+P  ++ A+  L F LP +SG      +TVLL  +VF+L++ +++PAT
Sbjct: 229 RTLY--YGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPAT 286

Query: 238 STSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHS 297
           S S    L+            YFA  + ++  S++ T+ +    H        +P+W   
Sbjct: 287 SDS--VPLI----------AQYFASTMIIVGLSVVVTVIVLQ-YHHHDPDGGKMPKWTRV 333

Query: 298 LLLH-CT--------GQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQM 340
           +LL+ C         G+ +  P    K  +   L    +  V  P  S G +
Sbjct: 334 ILLNWCAWFLRMKRPGEDKVRPACQHK-QRRCSLASVEMSAVAPPPASNGNL 384


>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
           precursor [Homo sapiens]
          Length = 502

 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 65/292 (22%), Positives = 121/292 (41%), Gaps = 44/292 (15%)

Query: 27  QLVTSFLWLNM--------WNPDECGGIKKSGMATENLWLSDVFIEESVDQTPAGLMASM 78
           Q++T+ +WL          W P+E   +KK  + ++++WL DV +  + D         M
Sbjct: 75  QIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNAD--------GM 126

Query: 79  SIVKATSNTISQCGWSASANWTP-SISPSMDRGERSPSALSPTQVTRAWRRMSRS----- 132
             V   SN +    +  S  W P +I  S  + E           T  +R  +       
Sbjct: 127 YEVSFYSNAV--VSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEID 184

Query: 133 ----FQIHHRTSFRTRREWVLLGIQKRTIKVTVATNQYEQAIFHVAIRRRCRPSPYVVNF 188
                ++     F    EW ++ +  R  +     + Y    +   IRR+  P  Y +N 
Sbjct: 185 LVLKSEVASLDDFTPSGEWDIVALPGRRNE-NPDDSTYVDITYDFIIRRK--PLFYTINL 241

Query: 189 LVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRP 248
           ++P  ++ ++  L FYLP + G      ++VLL  +VFLL+++ ++P TS      LV  
Sbjct: 242 IIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLD--VPLV-- 297

Query: 249 HPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLL 300
                   G Y    + L+  S++ ++ + ++ H + T     P W+  + L
Sbjct: 298 --------GKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAP-WVKVVFL 340


>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
           precursor [Homo sapiens]
          Length = 501

 Score = 62.0 bits (149), Expect = 9e-10
 Identities = 79/361 (21%), Positives = 136/361 (37%), Gaps = 83/361 (22%)

Query: 38  WNPDECGGIKKSGMATENLWLSDVFIEESVDQTPAGLMASMSIVKATSNTISQCGWSASA 97
           W+P E  GI    +  E++WL DV +  + D        +  +    S  +S  G   S 
Sbjct: 90  WDPAEHDGIDSLRITAESVWLPDVVLLNNND-------GNFDVALDISVVVSSDG---SV 139

Query: 98  NWTPSISPSMDRGERSPSALSPTQVTRAWRRMSRSF------------------------ 133
            W P   P +    RS  ++  T     W+  +  F                        
Sbjct: 140 RWQP---PGI---YRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQ 193

Query: 134 QIH-HRTSFRTRREWVLLGIQKRTIKVTV-----ATNQYEQAIFHVAIRRRCRPSPYVVN 187
           +IH H  +F    +W ++    R I+           Q ++ IF++ IRR+  P  Y+VN
Sbjct: 194 EIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIRRK--PLFYLVN 251

Query: 188 FLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVR 247
            + P  ++  +    FYLP ++G      +  LL  +VFLL++ D +P TS S    +  
Sbjct: 252 VIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIII-- 309

Query: 248 PHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGR 307
                      Y    + L+  S++ ++ + + LH  +     +P W+  + +H      
Sbjct: 310 ----------KYLMFTMVLVTFSVILSVVVLN-LHHRSPHTHQMPLWVRQIFIH------ 352

Query: 308 CCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQH 367
                           P +L  +K P+     MP P     + GS W R   E+  +K  
Sbjct: 353 --------------KLPLYL-RLKRPKPERDLMPEPPHCS-SPGSGWGRGTDEYFIRKPP 396

Query: 368 S 368
           S
Sbjct: 397 S 397


>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
           precursor [Homo sapiens]
          Length = 627

 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 68/301 (22%), Positives = 122/301 (40%), Gaps = 37/301 (12%)

Query: 16  ILHLLLQDSHLQLVTSFLWLNM--------WNPDECGGIKKSGMATENLWLSDVFIEESV 67
           I  L+  D   Q++T+ +W+          W+P +   +    + +E +W  D+ +  + 
Sbjct: 70  IAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNA 129

Query: 68  DQTPAGLMASMSIVKATSNTISQCGWSASANWTPSISPSMDRGERSPSALSPTQVTRAWR 127
           D    G  A   + KA      +  W+  A +  S S  +D         + T    +W 
Sbjct: 130 D----GDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCS--IDVTFFPFDQQNCTMKFGSWT 183

Query: 128 RMSRSFQI---HHRTS---FRTRREWVLLGI--QKRTIKVTVATNQYEQAIFHVAIRRRC 179
                  +   H R     F    EWV++       T K       Y    +   IRR  
Sbjct: 184 YDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRL- 242

Query: 180 RPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATST 239
            P  Y +N ++P  ++  +  L FYLP E G      ++VLL  +VFLL++ +++P+T  
Sbjct: 243 -PLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPST-- 299

Query: 240 SSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLL 299
               SLV P        G Y    +  +  S++ T+F+ + +H  + +   +P W+  + 
Sbjct: 300 ----SLVIP------LIGEYLLFTMIFVTLSIVITVFVLN-VHHRSPRTHTMPTWVRRVF 348

Query: 300 L 300
           L
Sbjct: 349 L 349


>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
          Length = 494

 Score = 58.9 bits (141), Expect = 8e-09
 Identities = 44/162 (27%), Positives = 73/162 (45%), Gaps = 17/162 (10%)

Query: 141 FRTRREWVLLGIQ--KRTIKVTVATNQYEQAIFHVAIRRRCRPSPYVVNFLVPSGILIAI 198
           F    EW ++     K  IK       Y    +   IRR   P  Y +N ++P   +  +
Sbjct: 200 FWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRL--PMFYTINLIIPCLFISFL 257

Query: 199 DALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGV 258
             L FYLP + G      ++VLL  +VFLL++ + +P+T      SLV P        G 
Sbjct: 258 TVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPST------SLVVP------LVGE 305

Query: 259 YFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLL 300
           Y    +  +  S++ T+F+ + +H  T     +PRW+ ++ L
Sbjct: 306 YLLFTMIFVTLSIVVTVFVLN-IHYRTPTTHTMPRWVKTVFL 346


>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 62/303 (20%), Positives = 118/303 (38%), Gaps = 45/303 (14%)

Query: 19  LLLQDSHLQLVTSFLWLNM--------WNPDECGGIKKSGMATENLWLSDVFIEESVDQT 70
           L+  D   Q++ + LWL          WNP + GG +   +  + +W  D+ +  +    
Sbjct: 71  LVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNN---- 126

Query: 71  PAGLMASMSIVKATSNTISQCGWSASANWTPSI----SPSMDRGERSPSALSPTQVTRAW 126
                 ++   +    T +   ++    W P      S  +D         + T    +W
Sbjct: 127 ------AVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSW 180

Query: 127 RRMSRSFQI------HHRTSFRTRREWVLLGIQ--KRTIKVTVATNQYEQAIFHVAIRRR 178
                   +       +   +    EW ++     K  IK       Y    + + IRR 
Sbjct: 181 SYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRL 240

Query: 179 CRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATS 238
             P  Y +N ++P  ++  +  L FYLP + G      ++VLL  +VFLL++ + +P+T 
Sbjct: 241 --PLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPST- 297

Query: 239 TSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSL 298
                SLV P        G Y    +  +  S++ T+F+ + +H  T     +P W+ ++
Sbjct: 298 -----SLVIP------LIGEYLLFTMIFVTLSIVITVFVLN-VHYRTPTTHTMPSWVKTV 345

Query: 299 LLH 301
            L+
Sbjct: 346 FLN 348


>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
          Length = 468

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 64/310 (20%), Positives = 121/310 (39%), Gaps = 55/310 (17%)

Query: 16  ILHLLLQDSHLQLVTSFLWLNM--------WNPDECGGIKKSGMATENLWLSDVFIEESV 67
           I  L+  D   QL+T+ +WL          WNPD+ GGIK   + ++++W  D+ + ++ 
Sbjct: 80  ISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNA 139

Query: 68  DQTPAGLMASMSIVKATSNTISQCGWSASANWTPSISPSMDRGERSPSALSPTQVTRAWR 127
           D    G           ++T +   ++ +  WTP  +       +S   +  T      +
Sbjct: 140 DGRFEG-----------TSTKTVIRYNGTVTWTPPAN------YKSSCTIDVTFFPFDLQ 182

Query: 128 RMSRSF----------------QIHHRTSFRTRREWVLLGIQKRTIKVTVATNQYEQAIF 171
             S  F                Q   +  F    EW ++         T +   Y    +
Sbjct: 183 NCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPYVTY 242

Query: 172 HVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMN 231
              I+R   P  Y +  ++P   L  +  L FYLP   G       +VL+  +VFLL++ 
Sbjct: 243 SFVIKR--LPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIE 300

Query: 232 DLLPATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPL 291
           +++P  S+S    L+          G Y    +  +  S++ T+F  ++ H +++    +
Sbjct: 301 EIIP--SSSKVIPLI----------GEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAM 348

Query: 292 PRWLHSLLLH 301
              +  + LH
Sbjct: 349 APLVRKIFLH 358


>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
          Length = 412

 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 56/206 (27%), Positives = 92/206 (44%), Gaps = 27/206 (13%)

Query: 146 EWVLLGIQ-KRTIKVTVATNQ-YEQAIFHVAIRRRCRPSPYVVNFLVPSGILIAIDALSF 203
           EW L+GI  KR+ +      + Y    F V +RRR     Y +N L+P  ++ A+  L F
Sbjct: 105 EWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLY--YGLNLLIPCVLISALALLVF 162

Query: 204 YLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGVYFALC 263
            LP +SG      +TVLL  +VF+L++ +++PATS S    L+            YFA  
Sbjct: 163 LLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDS--VPLI----------AQYFAST 210

Query: 264 LSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLH-CT--------GQGRCCPTAPQ 314
           + ++  S++ T+ +    H        +P+W   +LL+ C         G+ +  P    
Sbjct: 211 MIIVGLSVVVTVIVLQ-YHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQH 269

Query: 315 KGNKGPGLTPTHLPGVKEPEVSAGQM 340
           K  +   L    +  V  P  S G +
Sbjct: 270 K-QRRCSLASVEMSAVAPPPASNGNL 294


>gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
          Length = 321

 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 56/206 (27%), Positives = 92/206 (44%), Gaps = 27/206 (13%)

Query: 146 EWVLLGIQ-KRTIKVTVATNQ-YEQAIFHVAIRRRCRPSPYVVNFLVPSGILIAIDALSF 203
           EW L+GI  KR+ +      + Y    F V +RRR     Y +N L+P  ++ A+  L F
Sbjct: 14  EWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLY--YGLNLLIPCVLISALALLVF 71

Query: 204 YLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGVYFALC 263
            LP +SG      +TVLL  +VF+L++ +++PATS S    L+            YFA  
Sbjct: 72  LLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDS--VPLI----------AQYFAST 119

Query: 264 LSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLH-CT--------GQGRCCPTAPQ 314
           + ++  S++ T+ +    H        +P+W   +LL+ C         G+ +  P    
Sbjct: 120 MIIVGLSVVVTVIVLQ-YHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQH 178

Query: 315 KGNKGPGLTPTHLPGVKEPEVSAGQM 340
           K  +   L    +  V  P  S G +
Sbjct: 179 K-QRRCSLASVEMSAVAPPPASNGNL 203


>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 59/232 (25%), Positives = 97/232 (41%), Gaps = 49/232 (21%)

Query: 38  WNPDECGGIKKSGMATENLWLSDVFIEESVDQTPAGLMASMSIVKATSNTISQCGWSASA 97
           WN +E G I    +  + +WL ++ +E + D        S  I  + +  +   G+    
Sbjct: 90  WNAEEFGNISVLRLPPDMVWLPEIVLENNND-------GSFQISYSCNVLVYHYGF---V 139

Query: 98  NWTPSISPSMDRGERSPSALSPTQVTRAWRRMSRSFQ----------IHHRTSFRTRR-- 145
            W P   P++ R   S   +S T     W+  S  F           +  +   +  R  
Sbjct: 140 YWLP---PAIFR---SSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTY 193

Query: 146 --EWVLLG-----------IQKRTIKVTVATN------QYEQAIFHVAIRRRCRPSPYVV 186
             EW+++            I  R  +V V           +   F++ IRR+  P  Y++
Sbjct: 194 PVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRK--PLFYII 251

Query: 187 NFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATS 238
           N LVP  ++  +  L FYLP +SG      ++VLL  SVFLL+++  LPATS
Sbjct: 252 NILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATS 303


>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
          Length = 498

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 61/304 (20%), Positives = 118/304 (38%), Gaps = 44/304 (14%)

Query: 16  ILHLLLQDSHLQLVTSFLWLNM--------WNPDECGGIKKSGMATENLWLSDVFIEESV 67
           +  L+  +   Q++T+ +WL          WN     G+    +  + +WL D+ +  + 
Sbjct: 62  LAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNA 121

Query: 68  DQTPAGLMASMSIVKATSNTISQCGWSASANWTP-SISPSMDRGERSPSALSPTQVT--- 123
           D T    + +  IV++  + +          W P +I  S  + E           T   
Sbjct: 122 DGTYEVSVYTNLIVRSNGSVL----------WLPPAIYKSACKIEVKYFPFDQQNCTLKF 171

Query: 124 RAWRRMSRSFQIHHRT------SFRTRREWVLLGIQKRTIKVTVATNQYEQAIFHVAIRR 177
           R+W        +   T       F    EW ++ +  R   V      Y    +   I+R
Sbjct: 172 RSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVALPGRRT-VNPQDPSYVDVTYDFIIKR 230

Query: 178 RCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPAT 237
           +  P  Y +N ++P  +   +  L FYLP + G      ++VLL  + FLL+++ ++P T
Sbjct: 231 K--PLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPT 288

Query: 238 STSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHS 297
           S      L+          G Y    + L+  S++ ++ + ++ H + +     P W+  
Sbjct: 289 SLD--VPLI----------GKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAP-WVKR 335

Query: 298 LLLH 301
             LH
Sbjct: 336 CFLH 339


>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
           precursor [Homo sapiens]
          Length = 493

 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 54/262 (20%), Positives = 107/262 (40%), Gaps = 55/262 (20%)

Query: 16  ILHLLLQDSHLQLVTSFLWLNM--------WNPDECGGIKKSGMATENLWLSDVFIEESV 67
           + +L+  +   + +T+ +W+ +        ++ D+ GGI+   + +E +WL ++ +E ++
Sbjct: 57  LTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNI 116

Query: 68  DQTPAGLMASMSIVKATSNTISQCGWSASANWTPSISPSMDRGERSPSALSPTQVTRAWR 127
           D            V   +N +   G   S  W P   P++    RS  A+  T     W+
Sbjct: 117 D--------GQFGVAYDANVLVYEG--GSVTWLP---PAI---YRSVCAVEVTYFPFDWQ 160

Query: 128 RMSRSFQIHHRTSFRTRREWVLLGIQKRTIKVTVATNQYEQ------------------- 168
             S  F+     +      + +    K   K+ + T  Y +                   
Sbjct: 161 NCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGG 220

Query: 169 ---------AIFHVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLES-GNCAPFKMT 218
                     I+ + IRR+  P  YV+N +VP  ++  +  L+++LP ++ G      + 
Sbjct: 221 ATDGPGETDVIYSLIIRRK--PLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSIN 278

Query: 219 VLLGYSVFLLMMNDLLPATSTS 240
           VLL  +VFL ++   +P TS S
Sbjct: 279 VLLAQTVFLFLIAQKIPETSLS 300


>gi|206725456 zinc activated ligand-gated ion channel [Homo sapiens]
          Length = 412

 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 46/173 (26%), Positives = 70/173 (40%), Gaps = 29/173 (16%)

Query: 129 MSRSFQIHHRTSF-RTRREWVLLGIQKRTIKVTVATNQYEQAIFHVAIRRRCRPSPYVVN 187
           M   FQ H        +RE+V+  ++      T    Q     F V +R +      ++ 
Sbjct: 183 MELEFQAHVVNEIVSVKREYVVYDLK------TQVPPQQLVPCFQVTLRLKNTALKSIIA 236

Query: 188 FLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVR 247
            LVP+  L+  D     LPL +     +K+T+LL Y V                H+SLV+
Sbjct: 237 LLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVL---------------HSSLVQ 281

Query: 248 PHPSRDQKRGV---YFALCLSLMVGSLLETIFITHLLH----VATTQPLPLPR 293
             PS      +   YF + L L+  S +ET+ +  LL      A + P P PR
Sbjct: 282 ALPSSSSCNPLLIYYFTILLLLLFLSTIETVLLAGLLARGNLGAKSGPSPAPR 334


>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 55/262 (20%), Positives = 109/262 (41%), Gaps = 60/262 (22%)

Query: 16  ILHLLLQDSHLQLVTSFLWLNM--------WNPDECGGIKKSGMATENLWLSDVFIEESV 67
           + +L+  +   + +T+ +W+ M        W+P +  G+    + +  +W  D+ +E +V
Sbjct: 59  LTNLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNV 118

Query: 68  DQTPAGLMASMSIVKATSNTISQCGWSASANWTPSISPSMDRGERSPSALSPTQVTRAWR 127
           D           +    +  +S  G      W P   P++ R   S  ++S T     W+
Sbjct: 119 DGV-------FEVALYCNVLVSPDG---CIYWLP---PAIFR---SACSISVTYFPFDWQ 162

Query: 128 RMSRSFQIHHRTSFRTRR-------------EWVLL-----------GIQKRTIKVTV-- 161
             S  FQ     ++ T               EW+ +            IQ R  K+ +  
Sbjct: 163 NCSLIFQSQ---TYSTNEIDLQLSQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDP 219

Query: 162 -ATNQ---YEQAIFHVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLES-GNCAPFK 216
            A  Q   +++ +F++ I+R+  P  YV+N + P  ++ ++  L  +LP ++ G      
Sbjct: 220 AAPAQEAGHQKVVFYLLIQRK--PLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVA 277

Query: 217 MTVLLGYSVFLLMMNDLLPATS 238
           + VLL  +VFL ++   +P TS
Sbjct: 278 INVLLAQTVFLFLVAKKVPETS 299


>gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta
           precursor [Homo sapiens]
          Length = 452

 Score = 35.0 bits (79), Expect = 0.12
 Identities = 28/115 (24%), Positives = 52/115 (45%), Gaps = 14/115 (12%)

Query: 162 ATNQYEQAIFHVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLL 221
           +  Q+ +   H  +RR      Y++   +PS +L+A+  +SF++     + A     V L
Sbjct: 230 SAGQFPRLSLHFHLRRN--RGVYIIQSYMPSVLLVAMSWVSFWI-----SQAAVPARVSL 282

Query: 222 GYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIF 276
           G +  L M   ++ A S+   AS ++          VYF +C   +  +L+E  F
Sbjct: 283 GITTVLTMTTLMVSARSSLPRASAIK-------ALDVYFWICYVFVFAALVEYAF 330


>gi|88702793 slit-like 2 [Homo sapiens]
          Length = 673

 Score = 35.0 bits (79), Expect = 0.12
 Identities = 25/55 (45%), Positives = 27/55 (49%), Gaps = 3/55 (5%)

Query: 301 HCTGQGRCCPTAPQ-KGNKGPGLTPTHLPGVKEP-EVSAGQMPGPGEAELTGGSE 353
           +C  +GR    A Q KG  GPG  P  L GVK P E       G GEA L  GSE
Sbjct: 597 YCVRRGRAMAAAAQDKGQVGPGAGPLELEGVKVPLEPGPKATEGGGEA-LPSGSE 650


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.135    0.429 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,803,564
Number of Sequences: 37866
Number of extensions: 821749
Number of successful extensions: 2649
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 27
Number of HSP's that attempted gapping in prelim test: 2547
Number of HSP's gapped (non-prelim): 90
length of query: 404
length of database: 18,247,518
effective HSP length: 105
effective length of query: 299
effective length of database: 14,271,588
effective search space: 4267204812
effective search space used: 4267204812
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.