Search of human proteins with 222537752

Search of human proteins with 222537752

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|222537752 Src homology 2 domain containing transforming
protein D [Homo sapiens]
         (340 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|222537752 Src homology 2 domain containing transforming prote...   718   0.0  
gi|106879210 Src homology 2 domain containing adaptor protein B ...   249   2e-66
gi|111074524 Src homology 2 domain containing F [Homo sapiens]        245   5e-65
gi|58219064 Src homology 2 domain containing E [Homo sapiens]         202   3e-52
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]              68   1e-11
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]                68   1e-11
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]              68   1e-11
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]              68   1e-11
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]              68   1e-11
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...    62   7e-10
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...    62   7e-10
gi|194239668 SHC (Src homology 2 domain containing) transforming...    56   5e-08
gi|194239662 SHC (Src homology 2 domain containing) transforming...    56   5e-08
gi|194239664 SHC (Src homology 2 domain containing) transforming...    55   7e-08
gi|32261324 SHC (Src homology 2 domain containing) transforming ...    55   7e-08
gi|239787762 SH2 domain protein 2A isoform 4 [Homo sapiens]            55   1e-07
gi|239787758 SH2 domain protein 2A isoform 3 [Homo sapiens]            55   1e-07
gi|239787750 SH2 domain protein 2A isoform 2 [Homo sapiens]            55   1e-07
gi|239787783 SH2 domain protein 2A isoform 2 [Homo sapiens]            55   1e-07
gi|5453754 NCK adaptor protein 1 [Homo sapiens]                        53   4e-07
gi|4885455 SH2B adaptor protein 3 [Homo sapiens]                       52   6e-07
gi|242247193 SH2B adaptor protein 2 [Homo sapiens]                     52   1e-06
gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]               49   5e-06
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]        49   6e-06
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]       49   6e-06
gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo ...    49   8e-06
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]             49   8e-06
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]             49   8e-06
gi|4503787 fyn-related kinase [Homo sapiens]                           49   8e-06
gi|169790811 SHC (Src homology 2 domain containing) transforming...    49   8e-06

>gi|222537752 Src homology 2 domain containing transforming protein
           D [Homo sapiens]
          Length = 340

 Score =  718 bits (1853), Expect = 0.0
 Identities = 340/340 (100%), Positives = 340/340 (100%)

Query: 1   MAKWLRDYLSFGGRRPPPQPPTPDYTESDILRAYRAQKNLDFEDPYEDAESRLEPDPAGP 60
           MAKWLRDYLSFGGRRPPPQPPTPDYTESDILRAYRAQKNLDFEDPYEDAESRLEPDPAGP
Sbjct: 1   MAKWLRDYLSFGGRRPPPQPPTPDYTESDILRAYRAQKNLDFEDPYEDAESRLEPDPAGP 60

Query: 61  GDSKNPGDAKYGSPKHRLIKVEAADMARAKALLGGPGEELEADTEYLDPFDAQPHPAPPD 120
           GDSKNPGDAKYGSPKHRLIKVEAADMARAKALLGGPGEELEADTEYLDPFDAQPHPAPPD
Sbjct: 61  GDSKNPGDAKYGSPKHRLIKVEAADMARAKALLGGPGEELEADTEYLDPFDAQPHPAPPD 120

Query: 121 DGYMEPYDAQWVMSELPGRGVQLYDTPYEEQDPETADGPPSGQKPRQSRMPQEDERPADE 180
           DGYMEPYDAQWVMSELPGRGVQLYDTPYEEQDPETADGPPSGQKPRQSRMPQEDERPADE
Sbjct: 121 DGYMEPYDAQWVMSELPGRGVQLYDTPYEEQDPETADGPPSGQKPRQSRMPQEDERPADE 180

Query: 181 YDQPWEWKKDHISRAFAVQFDSPEWERTPGSAKELRRPPPRSPQPAERVDPALPLEKQPW 240
           YDQPWEWKKDHISRAFAVQFDSPEWERTPGSAKELRRPPPRSPQPAERVDPALPLEKQPW
Sbjct: 181 YDQPWEWKKDHISRAFAVQFDSPEWERTPGSAKELRRPPPRSPQPAERVDPALPLEKQPW 240

Query: 241 FHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVVLG 300
           FHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVVLG
Sbjct: 241 FHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVVLG 300

Query: 301 QHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP 340
           QHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP
Sbjct: 301 QHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP 340


>gi|106879210 Src homology 2 domain containing adaptor protein B
           [Homo sapiens]
          Length = 509

 Score =  249 bits (637), Expect = 2e-66
 Identities = 183/510 (35%), Positives = 233/510 (45%), Gaps = 173/510 (33%)

Query: 1   MAKWLRDYLSFGGRRP--PPQPPTPDYTE------------------------------- 27
           MAKWL  Y S G  +   PPQPP PDY E                               
Sbjct: 1   MAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATA 60

Query: 28  -----------------SDILRAYRAQKNLDFEDPYEDAESRLEPDPA-----GPGDSKN 65
                            SD++RAYRAQK  DFEDPY    S L    A       G S  
Sbjct: 61  SCFSASSGSLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGE 120

Query: 66  PG------------------------------DAKYGSP--------------------- 74
           PG                               +  GSP                     
Sbjct: 121 PGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGSPHLYRSSSERRPATPAEVRYIS 180

Query: 75  -KHRLIKVEAADMARAKALLG---------------------------------GPGEEL 100
            KHRLIKVE+A    A   LG                                 G  +++
Sbjct: 181 PKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKV 240

Query: 101 EADTEYLDPFDAQ-----PHPAPPDDGYMEPYDAQWVMSEL--------PGRGVQLYDTP 147
               +Y DPFDA+             GYMEPY+AQ +M+E           +G+QLYDTP
Sbjct: 241 TIADDYSDPFDAKNDLKSKAGKGESAGYMEPYEAQRIMTEFQRQESVRSQHKGIQLYDTP 300

Query: 148 YEEQDPETADGPPSGQKP--RQSRMPQEDERPADEYDQPWEWKKDHISRAFAVQFDSPEW 205
           YE +         S   P  R+S++PQ+D+RPADEYDQPWEW +  I  A A QF+  E 
Sbjct: 301 YEPEGQSVDSDSESTVSPRLRESKLPQDDDRPADEYDQPWEWNRVTIP-ALAAQFNGNEK 359

Query: 206 ERTPGSAKELRRPPPRSP----QP------------AERVDPALPLEKQPWFHGPLNRAD 249
            ++  S    RR   R+P    +P             ERVDPA+PLEKQ W+HG ++R D
Sbjct: 360 RQSSPSPSRDRRRQLRAPGGGFKPIKHGSPEFCGILGERVDPAVPLEKQIWYHGAISRGD 419

Query: 250 AESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSV 309
           AE+LL LCKE SYLVR S+T+  D SLSLRS+QGF+H+K A+T+E + VLGQ+S PF SV
Sbjct: 420 AENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKE-KYVLGQNSPPFDSV 478

Query: 310 PELVLHYSSRPLPVQGAEHLALLYPVVTQT 339
           PE++ +Y++R LP++GAEHL+LLYPV  +T
Sbjct: 479 PEVIHYYTTRKLPIKGAEHLSLLYPVAVRT 508


>gi|111074524 Src homology 2 domain containing F [Homo sapiens]
          Length = 423

 Score =  245 bits (625), Expect = 5e-65
 Identities = 149/367 (40%), Positives = 199/367 (54%), Gaps = 93/367 (25%)

Query: 55  PDPAGPGDSKNPGDAKYGSPKHRLIKVEAADMARAKALLGGPGEELEADTEYLDPFDAQ- 113
           P P   G  +        + + R+I++      R  A+L           +Y DPFD Q 
Sbjct: 67  PQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAIL----------EDYADPFDVQE 116

Query: 114 -----------PHPAPPDDGYMEPYDAQWVMSELPG------RGVQLYDTPYE-EQDPET 155
                      P   P +DGYMEPY+AQ +M+E+ G      + + LYDTPYE E+D  T
Sbjct: 117 TGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGAT 176

Query: 156 ADGPPSGQKPRQSRMPQEDERPADEYDQPWEWKKDHISRAFAV----------------- 198
            +G      PR+SR+P++DERP +EYDQPWEWKK+ IS+AFAV                 
Sbjct: 177 PEGE-GAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQL 235

Query: 199 ------------------------------QFDSPEWE-RTPGSAKELRRPP------PR 221
                                         QF+ PE    +PG  ++ R PP      P+
Sbjct: 236 DSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPK 295

Query: 222 SPQP---------AERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSETNPQ 272
           S +P          E  DPALPLE Q W+HG ++R DAE+LL LCKE SYLVR SET+  
Sbjct: 296 SAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKN 355

Query: 273 DCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALL 332
           D SLSL+SSQGF+H+K +RT+E++ VLGQ+S PF SVPE+V HY+SR LP++GAEH++LL
Sbjct: 356 DFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLL 415

Query: 333 YPVVTQT 339
           YPV  +T
Sbjct: 416 YPVAIRT 422


>gi|58219064 Src homology 2 domain containing E [Homo sapiens]
          Length = 495

 Score =  202 bits (514), Expect = 3e-52
 Identities = 116/293 (39%), Positives = 158/293 (53%), Gaps = 67/293 (22%)

Query: 105 EYLDPFDAQPHPAPPD-------DGYMEPYDAQWVMSELPGRGV---------------- 141
           +Y DP+DA+      D       DGYMEPYDAQ +++E+  RG                 
Sbjct: 203 DYADPYDAKRTKGQRDAERVGENDGYMEPYDAQQMITEIRRRGSKDPLVKALQLLDSPCE 262

Query: 142 -------------------------QLYDTPYEEQDPETADGPPSGQ---KPRQSRMPQE 173
                                    QLYDTPYE      A+G P  +   +P  SR+P+ 
Sbjct: 263 PADGGLKSETLAKRRSSKDLLGKPPQLYDTPYEP-----AEGGPRAEGKARPPDSRLPEN 317

Query: 174 DERPADEYDQPWEWKKDHISRAFAVQFDSPE-----------WERTPGSAKELRRPPPRS 222
           DERPA EY+QPWEWKK+ I RA +VQF+  E             R     +++ +P    
Sbjct: 318 DERPAAEYEQPWEWKKEQIVRALSVQFEGAERPSFREETVRQHHRQKSWTQKILKPALSD 377

Query: 223 PQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQ 282
               E+VDP LPLEKQPW+HG ++RA+AES L  CKE  YLVR SE+     S++L++SQ
Sbjct: 378 HSEGEKVDPGLPLEKQPWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQ 437

Query: 283 GFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPV 335
           G +H+  A+T++N+  L Q S  F S+PE+V +YS+  LP +GAEH+ LLYPV
Sbjct: 438 GCVHIIVAQTKDNKYTLNQTSAVFDSIPEVVHYYSNEKLPFKGAEHMTLLYPV 490


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 40/109 (36%), Positives = 60/109 (55%), Gaps = 1/109 (0%)

Query: 210 GSAKELRRPPPRSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSET 269
           G   E+R    +   P+  + P   LEK  W+HGP++R+ AE LLS    GS+LVR SE+
Sbjct: 128 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESES 187

Query: 270 NPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSS 318
           +P   S+SLR      H +   T + +V +   S  F ++ ELV H+S+
Sbjct: 188 SPGQLSISLRYEGRVYHYRINTTADGKVYVTAES-RFSTLAELVHHHST 235


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 40/109 (36%), Positives = 60/109 (55%), Gaps = 1/109 (0%)

Query: 210 GSAKELRRPPPRSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSET 269
           G   E+R    +   P+  + P   LEK  W+HGP++R+ AE LLS    GS+LVR SE+
Sbjct: 143 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESES 202

Query: 270 NPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSS 318
           +P   S+SLR      H +   T + +V +   S  F ++ ELV H+S+
Sbjct: 203 SPGQLSISLRYEGRVYHYRINTTADGKVYVTAES-RFSTLAELVHHHST 250


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 40/109 (36%), Positives = 60/109 (55%), Gaps = 1/109 (0%)

Query: 210 GSAKELRRPPPRSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSET 269
           G   E+R    +   P+  + P   LEK  W+HGP++R+ AE LLS    GS+LVR SE+
Sbjct: 122 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESES 181

Query: 270 NPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSS 318
           +P   S+SLR      H +   T + +V +   S  F ++ ELV H+S+
Sbjct: 182 SPGQLSISLRYEGRVYHYRINTTADGKVYVTAES-RFSTLAELVHHHST 229


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 40/109 (36%), Positives = 60/109 (55%), Gaps = 1/109 (0%)

Query: 210 GSAKELRRPPPRSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSET 269
           G   E+R    +   P+  + P   LEK  W+HGP++R+ AE LLS    GS+LVR SE+
Sbjct: 128 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESES 187

Query: 270 NPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSS 318
           +P   S+SLR      H +   T + +V +   S  F ++ ELV H+S+
Sbjct: 188 SPGQLSISLRYEGRVYHYRINTTADGKVYVTAES-RFSTLAELVHHHST 235


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 40/109 (36%), Positives = 60/109 (55%), Gaps = 1/109 (0%)

Query: 210 GSAKELRRPPPRSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSET 269
           G   E+R    +   P+  + P   LEK  W+HGP++R+ AE LLS    GS+LVR SE+
Sbjct: 107 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESES 166

Query: 270 NPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSS 318
           +P   S+SLR      H +   T + +V +   S  F ++ ELV H+S+
Sbjct: 167 SPGQLSISLRYEGRVYHYRINTTADGKVYVTAES-RFSTLAELVHHHST 214


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 35/94 (37%), Positives = 53/94 (56%), Gaps = 1/94 (1%)

Query: 225 PAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGF 284
           P+  + P   LEK  W+HGP++R  AE LLS    GS+LVR SE++P   S+SLR     
Sbjct: 112 PSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRV 171

Query: 285 LHLKFARTRENQVVLGQHSGPFPSVPELVLHYSS 318
            H +     + ++ +   S  F ++ ELV H+S+
Sbjct: 172 YHYRINTASDGKLYVSSES-RFNTLAELVHHHST 204


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 35/94 (37%), Positives = 53/94 (56%), Gaps = 1/94 (1%)

Query: 225 PAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGF 284
           P+  + P   LEK  W+HGP++R  AE LLS    GS+LVR SE++P   S+SLR     
Sbjct: 131 PSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRV 190

Query: 285 LHLKFARTRENQVVLGQHSGPFPSVPELVLHYSS 318
            H +     + ++ +   S  F ++ ELV H+S+
Sbjct: 191 YHYRINTASDGKLYVSSES-RFNTLAELVHHHST 223


>gi|194239668 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 4 [Homo sapiens]
          Length = 473

 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 60/188 (31%), Positives = 82/188 (43%), Gaps = 15/188 (7%)

Query: 158 GPPSGQKPR-QSRMPQEDERPADE-YDQPWEWKKDHISRAF-AVQFDSPEWERTPGSA-K 213
           G P G  P  + +MP     P  E +D P      ++ +A  AV    P      GSA +
Sbjct: 287 GQPVGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPR 346

Query: 214 ELRRPPP-----RSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSE 268
           +L    P     R P P + V  A  L  +PWFHG L+R +AE+LL L   G +LVR S 
Sbjct: 347 DLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQL--NGDFLVREST 404

Query: 269 TNPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGA-E 327
           T P    L+   S    HL      + + V+      F SV  L+ ++    LP+  A  
Sbjct: 405 TTPGQYVLTGLQSGQPKHLLLV---DPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 461

Query: 328 HLALLYPV 335
            L L  PV
Sbjct: 462 ELCLQQPV 469


>gi|194239662 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 1 [Homo sapiens]
          Length = 583

 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 60/188 (31%), Positives = 82/188 (43%), Gaps = 15/188 (7%)

Query: 158 GPPSGQKPR-QSRMPQEDERPADE-YDQPWEWKKDHISRAF-AVQFDSPEWERTPGSA-K 213
           G P G  P  + +MP     P  E +D P      ++ +A  AV    P      GSA +
Sbjct: 397 GQPVGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPR 456

Query: 214 ELRRPPP-----RSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSE 268
           +L    P     R P P + V  A  L  +PWFHG L+R +AE+LL L   G +LVR S 
Sbjct: 457 DLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQL--NGDFLVREST 514

Query: 269 TNPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGA-E 327
           T P    L+   S    HL      + + V+      F SV  L+ ++    LP+  A  
Sbjct: 515 TTPGQYVLTGLQSGQPKHLLLV---DPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 571

Query: 328 HLALLYPV 335
            L L  PV
Sbjct: 572 ELCLQQPV 579


>gi|194239664 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 3 [Homo sapiens]
          Length = 584

 Score = 55.5 bits (132), Expect = 7e-08
 Identities = 60/189 (31%), Positives = 82/189 (43%), Gaps = 16/189 (8%)

Query: 158 GPPSGQKPR-QSRMPQEDERPADE--YDQPWEWKKDHISRAF-AVQFDSPEWERTPGSA- 212
           G P G  P  + +MP     PA    +D P      ++ +A  AV    P      GSA 
Sbjct: 397 GQPVGGDPEVRKQMPPPPPCPAGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAP 456

Query: 213 KELRRPPP-----RSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLS 267
           ++L    P     R P P + V  A  L  +PWFHG L+R +AE+LL L   G +LVR S
Sbjct: 457 RDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQL--NGDFLVRES 514

Query: 268 ETNPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGA- 326
            T P    L+   S    HL      + + V+      F SV  L+ ++    LP+  A 
Sbjct: 515 TTTPGQYVLTGLQSGQPKHLLLV---DPEGVVRTKDHRFESVSHLISYHMDNHLPIISAG 571

Query: 327 EHLALLYPV 335
             L L  PV
Sbjct: 572 SELCLQQPV 580


>gi|32261324 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 2 [Homo sapiens]
          Length = 474

 Score = 55.5 bits (132), Expect = 7e-08
 Identities = 60/189 (31%), Positives = 82/189 (43%), Gaps = 16/189 (8%)

Query: 158 GPPSGQKPR-QSRMPQEDERPADE--YDQPWEWKKDHISRAF-AVQFDSPEWERTPGSA- 212
           G P G  P  + +MP     PA    +D P      ++ +A  AV    P      GSA 
Sbjct: 287 GQPVGGDPEVRKQMPPPPPCPAGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAP 346

Query: 213 KELRRPPP-----RSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLS 267
           ++L    P     R P P + V  A  L  +PWFHG L+R +AE+LL L   G +LVR S
Sbjct: 347 RDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQL--NGDFLVRES 404

Query: 268 ETNPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGA- 326
            T P    L+   S    HL      + + V+      F SV  L+ ++    LP+  A 
Sbjct: 405 TTTPGQYVLTGLQSGQPKHLLLV---DPEGVVRTKDHRFESVSHLISYHMDNHLPIISAG 461

Query: 327 EHLALLYPV 335
             L L  PV
Sbjct: 462 SELCLQQPV 470


>gi|239787762 SH2 domain protein 2A isoform 4 [Homo sapiens]
          Length = 361

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 39/102 (38%), Positives = 54/102 (52%), Gaps = 6/102 (5%)

Query: 240 WFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQ-VV 298
           WFHG + R +AE LL    +G YLVR SE +     L+ RS     H   A+ R+ + VV
Sbjct: 67  WFHGFITRREAERLLEPKPQGCYLVRFSE-SAVTFVLTYRSRTCCRHFLLAQLRDGRHVV 125

Query: 299 LGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP 340
           LG+ S     + +L+LHY++ PL   G     L  P+  QTP
Sbjct: 126 LGEDSA-HARLQDLLLHYTAHPLSPYGE---TLTEPLARQTP 163


>gi|239787758 SH2 domain protein 2A isoform 3 [Homo sapiens]
          Length = 371

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 39/102 (38%), Positives = 54/102 (52%), Gaps = 6/102 (5%)

Query: 240 WFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQ-VV 298
           WFHG + R +AE LL    +G YLVR SE +     L+ RS     H   A+ R+ + VV
Sbjct: 77  WFHGFITRREAERLLEPKPQGCYLVRFSE-SAVTFVLTYRSRTCCRHFLLAQLRDGRHVV 135

Query: 299 LGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP 340
           LG+ S     + +L+LHY++ PL   G     L  P+  QTP
Sbjct: 136 LGEDSA-HARLQDLLLHYTAHPLSPYGE---TLTEPLARQTP 173


>gi|239787750 SH2 domain protein 2A isoform 2 [Homo sapiens]
          Length = 389

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 39/102 (38%), Positives = 54/102 (52%), Gaps = 6/102 (5%)

Query: 240 WFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQ-VV 298
           WFHG + R +AE LL    +G YLVR SE +     L+ RS     H   A+ R+ + VV
Sbjct: 95  WFHGFITRREAERLLEPKPQGCYLVRFSE-SAVTFVLTYRSRTCCRHFLLAQLRDGRHVV 153

Query: 299 LGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP 340
           LG+ S     + +L+LHY++ PL   G     L  P+  QTP
Sbjct: 154 LGEDSA-HARLQDLLLHYTAHPLSPYGE---TLTEPLARQTP 191


>gi|239787783 SH2 domain protein 2A isoform 2 [Homo sapiens]
          Length = 389

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 39/102 (38%), Positives = 54/102 (52%), Gaps = 6/102 (5%)

Query: 240 WFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQ-VV 298
           WFHG + R +AE LL    +G YLVR SE +     L+ RS     H   A+ R+ + VV
Sbjct: 95  WFHGFITRREAERLLEPKPQGCYLVRFSE-SAVTFVLTYRSRTCCRHFLLAQLRDGRHVV 153

Query: 299 LGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP 340
           LG+ S     + +L+LHY++ PL   G     L  P+  QTP
Sbjct: 154 LGEDSA-HARLQDLLLHYTAHPLSPYGE---TLTEPLARQTP 191


>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
          Length = 377

 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 34/103 (33%), Positives = 54/103 (52%), Gaps = 6/103 (5%)

Query: 222 SPQPAERVDPALP--LEKQPWFHGPLNRADAESLLS-LCKEGSYLVRLSETNPQDCSLSL 278
           SP   + + P+L       PW++G + R  AE  L+    EG +L+R SE++P D S+SL
Sbjct: 262 SPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSL 321

Query: 279 RSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPL 321
           ++     H K  + +E    +GQ    F ++ ELV HY   P+
Sbjct: 322 KAQGKNKHFK-VQLKETVYCIGQRK--FSTMEELVEHYKKAPI 361


>gi|4885455 SH2B adaptor protein 3 [Homo sapiens]
          Length = 575

 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 43/128 (33%), Positives = 62/128 (48%), Gaps = 14/128 (10%)

Query: 225 PAERVDPALP-----LEKQPWFHGPLNRADAESLLSL---CKEGSYLVRLSETNPQDCSL 276
           P   +DPA       L   PWFHGP++R  A  L+ L      G +LVR SET   +  L
Sbjct: 344 PGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVL 403

Query: 277 SLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQ-GAE---HLALL 332
           +        HL+ + T   Q  + QH   FPSV +++ H+   P+P++ GA     L+  
Sbjct: 404 TFNFQGIAKHLRLSLTERGQCRV-QHL-HFPSVVDMLHHFQRSPIPLECGAACDVRLSSY 461

Query: 333 YPVVTQTP 340
             VV+Q P
Sbjct: 462 VVVVSQPP 469


>gi|242247193 SH2B adaptor protein 2 [Homo sapiens]
          Length = 675

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 38/140 (27%), Positives = 62/140 (44%), Gaps = 7/140 (5%)

Query: 206 ERTPGSAKELRRPPPRSPQPAERVDPALPLEKQPWFHGPLNRADAESLL---SLCKEGSY 262
           E   GS  +      +  +     +P L L   PWFHG L+R  A  L+        G +
Sbjct: 426 ESPGGSGSDSNNTGEQGAETDPEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLF 485

Query: 263 LVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLP 322
           ++R SET P +  L+        HL+ +     Q  + QH   F SV +++ H+ + P+P
Sbjct: 486 VIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHV-QHLW-FQSVLDMLRHFHTHPIP 543

Query: 323 VQ--GAEHLALLYPVVTQTP 340
           ++  G+  + L   V  Q P
Sbjct: 544 LESGGSADITLRSYVRAQDP 563


>gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]
          Length = 330

 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 28/85 (32%), Positives = 45/85 (52%), Gaps = 2/85 (2%)

Query: 240 WFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVVL 299
           WFH  L+R  AE+LL   + G +++R S+++P D S+S+R      H K  R  +    L
Sbjct: 58  WFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL 117

Query: 300 GQHSGPFPSVPELVLHYSSRPLPVQ 324
                 FPS+ +LV +Y +  +  Q
Sbjct: 118 WTEK--FPSLNKLVDYYRTNSISRQ 140


>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
          Length = 1047

 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 31/107 (28%), Positives = 55/107 (51%), Gaps = 13/107 (12%)

Query: 234 PLEKQPWFHGPLNRADAESLL-SLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFART 292
           P E + WFHG +++ +A +LL ++ +  S+LVR S+  P D SL  R+++     K   T
Sbjct: 345 PHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPT 404

Query: 293 RENQVVLGQHSGPFPSVPELVLHYS----------SRPLPVQGAEHL 329
             NQ ++G     + S+ +++ HY             P+P+Q  E +
Sbjct: 405 PNNQFMMGGRY--YNSIGDIIDHYRKEQIVEGYYLKEPVPMQDQEQV 449



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 38/119 (31%), Positives = 56/119 (47%), Gaps = 11/119 (9%)

Query: 227 ERVDPALPLEKQP---WFHGPLNRADAESLLSLC-KEGSYLVRLSETNPQDCSLSLRSSQ 282
           E  + A+PL   P   W+HG L+R  AE  L    K GSYL+R S+  P    LS  S  
Sbjct: 165 EEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQM 224

Query: 283 GFL-HLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP 340
             + H +      +  + G+    F S+ +L+ +YS     ++G +   LLYPV    P
Sbjct: 225 NVVNHFRIIAMCGDYYIGGRR---FSSLSDLIGYYSHVSCLLKGEK---LLYPVAPPEP 277


>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
          Length = 870

 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 31/107 (28%), Positives = 55/107 (51%), Gaps = 13/107 (12%)

Query: 234 PLEKQPWFHGPLNRADAESLL-SLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFART 292
           P E + WFHG +++ +A +LL ++ +  S+LVR S+  P D SL  R+++     K   T
Sbjct: 168 PHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPT 227

Query: 293 RENQVVLGQHSGPFPSVPELVLHYS----------SRPLPVQGAEHL 329
             NQ ++G     + S+ +++ HY             P+P+Q  E +
Sbjct: 228 PNNQFMMGGRY--YNSIGDIIDHYRKEQIVEGYYLKEPVPMQDQEQV 272



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 33/103 (32%), Positives = 49/103 (47%), Gaps = 8/103 (7%)

Query: 240 WFHGPLNRADAESLLSLC-KEGSYLVRLSETNPQDCSLSLRSSQGFL-HLKFARTRENQV 297
           W+HG L+R  AE  L    K GSYL+R S+  P    LS  S    + H +      +  
Sbjct: 4   WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY 63

Query: 298 VLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP 340
           + G+    F S+ +L+ +YS     ++G +   LLYPV    P
Sbjct: 64  IGGRR---FSSLSDLIGYYSHVSCLLKGEK---LLYPVAPPEP 100


>gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo
           sapiens]
          Length = 475

 Score = 48.5 bits (114), Expect = 8e-06
 Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 9/122 (7%)

Query: 223 PQPAERVDPALPLEKQ----PWFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSL 278
           P P  R  P  P E+Q    PW+HG ++R  AE +L    +G +LVR S TNP    L+ 
Sbjct: 359 PSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLR--ADGDFLVRDSVTNPGQYVLTG 416

Query: 279 RSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQ 338
             +    HL      + + V+      F S+  L+ H+     P+  AE    L  VV++
Sbjct: 417 MHAGQPKHLLLV---DPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVSR 473

Query: 339 TP 340
            P
Sbjct: 474 EP 475


>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
          Length = 380

 Score = 48.5 bits (114), Expect = 8e-06
 Identities = 35/97 (36%), Positives = 54/97 (55%), Gaps = 6/97 (6%)

Query: 240 WFHGPLNRADAESLLS-LCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVV 298
           W++G + R  AE  L+    EG +L+R SE++P D S+SL++S    H K  +  +N   
Sbjct: 285 WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFK-VQLVDNVYC 343

Query: 299 LGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPV 335
           +GQ    F ++ ELV HY  +  P+  +EH   LY V
Sbjct: 344 IGQRR--FHTMDELVEHY--KKAPIFTSEHGEKLYLV 376


>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
          Length = 380

 Score = 48.5 bits (114), Expect = 8e-06
 Identities = 35/97 (36%), Positives = 54/97 (55%), Gaps = 6/97 (6%)

Query: 240 WFHGPLNRADAESLLS-LCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVV 298
           W++G + R  AE  L+    EG +L+R SE++P D S+SL++S    H K  +  +N   
Sbjct: 285 WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFK-VQLVDNVYC 343

Query: 299 LGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPV 335
           +GQ    F ++ ELV HY  +  P+  +EH   LY V
Sbjct: 344 IGQRR--FHTMDELVEHY--KKAPIFTSEHGEKLYLV 376


>gi|4503787 fyn-related kinase [Homo sapiens]
          Length = 505

 Score = 48.5 bits (114), Expect = 8e-06
 Identities = 36/114 (31%), Positives = 57/114 (50%), Gaps = 8/114 (7%)

Query: 206 ERTPGSAKELRRPPPRSPQPAERVDPALPLEKQPWFHGPLNRADAES--LLSLCKEGSYL 263
           +R  GS+++L+   P +    +R      L+ +PWF G + R+DAE   L S  K GS+L
Sbjct: 87  KRRDGSSQQLQGYIPSNYVAEDR-----SLQAEPWFFGAIGRSDAEKQLLYSENKTGSFL 141

Query: 264 VRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYS 317
           +R SE+   + SLS+       H +  R  E    L +    F ++ E V HY+
Sbjct: 142 IRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRRR-IFSTLNEFVSHYT 194


>gi|169790811 SHC (Src homology 2 domain containing) transforming
           protein 2 [Homo sapiens]
          Length = 582

 Score = 48.5 bits (114), Expect = 8e-06
 Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 9/122 (7%)

Query: 223 PQPAERVDPALPLEKQ----PWFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSL 278
           P P  R  P  P E+Q    PW+HG ++R  AE +L    +G +LVR S TNP    L+ 
Sbjct: 466 PSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLR--ADGDFLVRDSVTNPGQYVLTG 523

Query: 279 RSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQ 338
             +    HL      + + V+      F S+  L+ H+     P+  AE    L  VV++
Sbjct: 524 MHAGQPKHLLLV---DPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVSR 580

Query: 339 TP 340
            P
Sbjct: 581 EP 582


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.134    0.419 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,083,282
Number of Sequences: 37866
Number of extensions: 1144084
Number of successful extensions: 5344
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 90
Number of HSP's successfully gapped in prelim test: 230
Number of HSP's that attempted gapping in prelim test: 4946
Number of HSP's gapped (non-prelim): 559
length of query: 340
length of database: 18,247,518
effective HSP length: 103
effective length of query: 237
effective length of database: 14,347,320
effective search space: 3400314840
effective search space used: 3400314840
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.