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Search of human proteins with 222446609
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222446609 rai-like protein [Homo sapiens]
(630 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222446609 rai-like protein [Homo sapiens] 1290 0.0
gi|194239664 SHC (Src homology 2 domain containing) transforming... 473 e-133
gi|194239662 SHC (Src homology 2 domain containing) transforming... 473 e-133
gi|224586793 src homology 2 domain-containing transforming prote... 452 e-127
gi|32261324 SHC (Src homology 2 domain containing) transforming ... 430 e-120
gi|194239668 SHC (Src homology 2 domain containing) transforming... 429 e-120
gi|169790811 SHC (Src homology 2 domain containing) transforming... 374 e-103
gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo ... 127 4e-29
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 72 1e-12
gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens] 59 2e-08
gi|242247193 SH2B adaptor protein 2 [Homo sapiens] 58 3e-08
gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens] 56 1e-07
gi|216547790 SH2 domain containing 3C isoform d [Homo sapiens] 56 1e-07
gi|216547763 SH2 domain containing 3C isoform b [Homo sapiens] 56 1e-07
gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens] 56 1e-07
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 54 6e-07
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] 54 6e-07
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 52 1e-06
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 52 1e-06
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 52 1e-06
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 52 1e-06
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 52 1e-06
gi|224926826 SH2B adaptor protein 1 isoform 1 [Homo sapiens] 52 1e-06
gi|224926824 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 52 2e-06
gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens] 52 2e-06
gi|224926828 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 52 2e-06
gi|224926822 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 52 2e-06
gi|22035548 amyloid beta A4 precursor protein-binding, family A,... 52 2e-06
gi|106879210 Src homology 2 domain containing adaptor protein B ... 52 2e-06
gi|111074524 Src homology 2 domain containing F [Homo sapiens] 52 2e-06
>gi|222446609 rai-like protein [Homo sapiens]
Length = 630
Score = 1290 bits (3337), Expect = 0.0
Identities = 630/630 (100%), Positives = 630/630 (100%)
Query: 1 MRERGQDSLAGLVLYVGLFGHPGMLHRAKYSRFRNESITSLDEGSSGGSVGNKGSPQPPH 60
MRERGQDSLAGLVLYVGLFGHPGMLHRAKYSRFRNESITSLDEGSSGGSVGNKGSPQPPH
Sbjct: 1 MRERGQDSLAGLVLYVGLFGHPGMLHRAKYSRFRNESITSLDEGSSGGSVGNKGSPQPPH 60
Query: 61 PALAPHLPTEDATLPSQESPTPLCTLIPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQ 120
PALAPHLPTEDATLPSQESPTPLCTLIPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQ
Sbjct: 61 PALAPHLPTEDATLPSQESPTPLCTLIPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQ 120
Query: 121 ESRDPGSSGPSSPETSLSRSGTAPPPQQDLVGHRATALTPDSCPLPGPGEPTLRSRQDRH 180
ESRDPGSSGPSSPETSLSRSGTAPPPQQDLVGHRATALTPDSCPLPGPGEPTLRSRQDRH
Sbjct: 121 ESRDPGSSGPSSPETSLSRSGTAPPPQQDLVGHRATALTPDSCPLPGPGEPTLRSRQDRH 180
Query: 181 FLQHLLGMGMNYCVRYMGCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIKKRK 240
FLQHLLGMGMNYCVRYMGCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIKKRK
Sbjct: 181 FLQHLLGMGMNYCVRYMGCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIKKRK 240
Query: 241 PPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGGDPDT 300
PPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGGDPDT
Sbjct: 241 PPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGGDPDT 300
Query: 301 TDYVAYVAKDPVNQRACHILECHNGMAQDVISTIGQAFELRFKQYLKNPSLNTSCESEEV 360
TDYVAYVAKDPVNQRACHILECHNGMAQDVISTIGQAFELRFKQYLKNPSLNTSCESEEV
Sbjct: 301 TDYVAYVAKDPVNQRACHILECHNGMAQDVISTIGQAFELRFKQYLKNPSLNTSCESEEV 360
Query: 361 HIDSHAEEREDHEYYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPIQCEKLCYLPGNSKC 420
HIDSHAEEREDHEYYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPIQCEKLCYLPGNSKC
Sbjct: 361 HIDSHAEEREDHEYYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPIQCEKLCYLPGNSKC 420
Query: 421 SSVYENCLEQSRAIGNVHPRGVQSQRDTSLLKHTCRVDLFDDPCYINTQALQSTPGSAGN 480
SSVYENCLEQSRAIGNVHPRGVQSQRDTSLLKHTCRVDLFDDPCYINTQALQSTPGSAGN
Sbjct: 421 SSVYENCLEQSRAIGNVHPRGVQSQRDTSLLKHTCRVDLFDDPCYINTQALQSTPGSAGN 480
Query: 481 QRSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLL 540
QRSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLL
Sbjct: 481 QRSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLL 540
Query: 541 VKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDN 600
VKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDN
Sbjct: 541 VKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDN 600
Query: 601 SLPIISSGSEVSLKQPVRKDNNPALLHSNK 630
SLPIISSGSEVSLKQPVRKDNNPALLHSNK
Sbjct: 601 SLPIISSGSEVSLKQPVRKDNNPALLHSNK 630
>gi|194239664 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 3 [Homo sapiens]
Length = 584
Score = 473 bits (1218), Expect = e-133
Identities = 300/640 (46%), Positives = 370/640 (57%), Gaps = 111/640 (17%)
Query: 27 RAKYSRFRNESITSLDEGSSGGSVGNKGSPQPPHPALAPHLPTEDATLPSQESPTPLCTL 86
+ KY+ RNES++SL+EG+SG S + P P +L P LP LP +SPT LC+
Sbjct: 7 KPKYNPLRNESLSSLEEGASG-STPPEELPSPSASSLGPILPP----LPGDDSPTTLCSF 61
Query: 87 IPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQESRDPGSSGPSSPETSLSRSGTAPPP 146
PRM++++LANPA PGS G G A
Sbjct: 62 FPRMSNLRLANPA----------------------GGRPGSKG---------EPGRAADD 90
Query: 147 QQDLVGHRATALTPDSCPLP----------GPGEPTL--------------------RSR 176
+ +VG A PDS PLP G G T +R
Sbjct: 91 GEGIVG----AAMPDSGPLPLLQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTR 146
Query: 177 QDRHFLQHLLGMGMNYCVRYMGCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAI 236
H ++G G++Y VRYMGCVEVLQSMR+LDF RTQVTREAIS +CEAVPGA GA
Sbjct: 147 GWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGAT 206
Query: 237 KKRKPPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGG 296
++RKP + LS++LG+SNL+F+GM I LT+ST SL LM D +QIIANHHMQSISFASGG
Sbjct: 207 RRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGG 266
Query: 297 DPDTTDYVAYVAKDPVNQRACHILECHNGMAQDVISTIGQAFELRFKQYLKNPSLNTSCE 356
DPDT +YVAYVAKDPVNQRACHILEC G+AQDVISTIGQAFELRFKQYL+NP +
Sbjct: 267 DPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPH 326
Query: 357 SEEVHIDSHA-----EEREDHEYYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPIQCEKL 411
D A EE DH+YYN+ PGK+PP+GGV DMR++ A
Sbjct: 327 DRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAA------------- 373
Query: 412 CYLPGNSKCSSVYENCLEQSRAIGNVHPRGVQSQRDTSLLKH-----TCRV--DLFDDPC 464
PG ++ ++ N S +G P G D + K C +LFDDP
Sbjct: 374 ---PGAARPTA--PNAQTPSH-LGATLPVGQPVGGDPEVRKQMPPPPPCPAGRELFDDPS 427
Query: 465 YINTQALQSTPGSAGNQRSAQPLGSPWHCGKAPE---TVQP--GATAQPASSHSLPHIKQ 519
Y+N Q L + G P + G AP ++P A P S+ + +
Sbjct: 428 YVNVQNLDKARQAVGGAGPPNPAIN----GSAPRDLFDMKPFEDALRVPPPPQSV-SMAE 482
Query: 520 QLWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGK 579
QL E +HGKLSR+ AE+LL +GDFLVRES T+PGQYVL+GLQ GQ KHLLLVDPEG
Sbjct: 483 QLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGV 542
Query: 580 VRTKDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRK 619
VRTKDH F++V HLI YHMDN LPIIS+GSE+ L+QPV +
Sbjct: 543 VRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVER 582
>gi|194239662 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 1 [Homo sapiens]
Length = 583
Score = 473 bits (1216), Expect = e-133
Identities = 300/639 (46%), Positives = 370/639 (57%), Gaps = 110/639 (17%)
Query: 27 RAKYSRFRNESITSLDEGSSGGSVGNKGSPQPPHPALAPHLPTEDATLPSQESPTPLCTL 86
+ KY+ RNES++SL+EG+SG S + P P +L P LP LP +SPT LC+
Sbjct: 7 KPKYNPLRNESLSSLEEGASG-STPPEELPSPSASSLGPILPP----LPGDDSPTTLCSF 61
Query: 87 IPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQESRDPGSSGPSSPETSLSRSGTAPPP 146
PRM++++LANPA PGS G G A
Sbjct: 62 FPRMSNLRLANPA----------------------GGRPGSKG---------EPGRAADD 90
Query: 147 QQDLVGHRATALTPDSCPLP----------GPGEPTL--------------------RSR 176
+ +VG A PDS PLP G G T +R
Sbjct: 91 GEGIVG----AAMPDSGPLPLLQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTR 146
Query: 177 QDRHFLQHLLGMGMNYCVRYMGCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAI 236
H ++G G++Y VRYMGCVEVLQSMR+LDF RTQVTREAIS +CEAVPGA GA
Sbjct: 147 GWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGAT 206
Query: 237 KKRKPPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGG 296
++RKP + LS++LG+SNL+F+GM I LT+ST SL LM D +QIIANHHMQSISFASGG
Sbjct: 207 RRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGG 266
Query: 297 DPDTTDYVAYVAKDPVNQRACHILECHNGMAQDVISTIGQAFELRFKQYLKNPSLNTSCE 356
DPDT +YVAYVAKDPVNQRACHILEC G+AQDVISTIGQAFELRFKQYL+NP +
Sbjct: 267 DPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPH 326
Query: 357 SEEVHIDSHA-----EEREDHEYYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPIQCEKL 411
D A EE DH+YYN+ PGK+PP+GGV DMR++ A
Sbjct: 327 DRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAA------------- 373
Query: 412 CYLPGNSKCSSVYENCLEQSRAIGNVHPRGVQSQRDTSLLKH-----TC-RVDLFDDPCY 465
PG ++ ++ N S +G P G D + K C +LFDDP Y
Sbjct: 374 ---PGAARPTA--PNAQTPSH-LGATLPVGQPVGGDPEVRKQMPPPPPCPGRELFDDPSY 427
Query: 466 INTQALQSTPGSAGNQRSAQPLGSPWHCGKAPE---TVQP--GATAQPASSHSLPHIKQQ 520
+N Q L + G P + G AP ++P A P S+ + +Q
Sbjct: 428 VNVQNLDKARQAVGGAGPPNPAIN----GSAPRDLFDMKPFEDALRVPPPPQSV-SMAEQ 482
Query: 521 LWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKV 580
L E +HGKLSR+ AE+LL +GDFLVRES T+PGQYVL+GLQ GQ KHLLLVDPEG V
Sbjct: 483 LRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVV 542
Query: 581 RTKDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRK 619
RTKDH F++V HLI YHMDN LPIIS+GSE+ L+QPV +
Sbjct: 543 RTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVER 581
>gi|224586793 src homology 2 domain-containing transforming protein
C3 [Homo sapiens]
Length = 594
Score = 452 bits (1162), Expect = e-127
Identities = 278/633 (43%), Positives = 371/633 (58%), Gaps = 78/633 (12%)
Query: 24 MLHRAKYSRFRNESITSLDE-----GSSGGSVGNKGSPQPPHPALAPHLPTEDATLPS-Q 77
ML R KY+RFRN+S+TS+D+ SGG G K S PA AP+L + +A +
Sbjct: 1 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGG--GGKVSAARATPAAAPYLVSGEALRKAPD 58
Query: 78 ESPTPLCTLIPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQESRDPGSSGPSSPETSL 137
+ P L L+ +++ +KL++ L+ +E +L SG S +
Sbjct: 59 DGPGSLGHLLHKVSHLKLSSSG----LRGLSSAARERAGARL--------SGSCSAPSLA 106
Query: 138 SRSGTAPPPQQDLVGHRATALTPDSCPLPGPGEPTLRSRQDRHFLQHLLGMGMNYCVRYM 197
+ G+AP + A P PLP P R H +LG G+ Y V+Y+
Sbjct: 107 APDGSAPSAPRAPAMSAARKGRPGDEPLPRP------PRGAPHASDQVLGPGVTYVVKYL 160
Query: 198 GCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIKKRKPPVKFLSTVLGKSNLQF 257
GC+EVL+SMRSLDF RTQ+TREAISR+CEAVPGA GA KKRKPP K LS++LGKSNLQF
Sbjct: 161 GCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQF 220
Query: 258 SGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGGDPDTTDYVAYVAKDPVNQRAC 317
+GM+I LTIST SL L D++QIIANHHM+SISFASGGDPDTTDYVAYVAKDPVN+RAC
Sbjct: 221 AGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRAC 280
Query: 318 HILECHNGMAQDVISTIGQAFELRFKQYLKNPSLNTSCESEEVHIDSHAEERE----DHE 373
HILEC +G+AQDVI +IGQAFELRFKQYL+ P+ + +D E E DH
Sbjct: 281 HILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHP 340
Query: 374 YYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPIQCEKLCYLPGNSKCSSVYENCLEQSRA 433
YYN IP K PP GG D R+K + + P ++ + E Q R
Sbjct: 341 YYNSIPSKMPPPGGFLDTRLKPRP---------------HAPDTAQFAG-KEQTYYQGRH 384
Query: 434 IGNVHPRGVQS---QRDTSLLKHTCRVDLF-----DDPCYINTQAL--QSTPGSAGNQRS 483
+G+ Q ++ +S + T L + P Y+NTQ + Q+ P + + S
Sbjct: 385 LGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQAWPAAVSSAES 444
Query: 484 A-----------------QPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEEC 526
+ QPLG + E + P + P + + ++L +E
Sbjct: 445 SPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAK-----MLEELQAETW 499
Query: 527 YHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHV 586
Y G++SRK AE LL KDGDFLVR+S T+PG +VL+G+ GQAKHLLLVDPEG +RTKD V
Sbjct: 500 YQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIRTKDRV 559
Query: 587 FDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRK 619
FD++ HLI +H+++SLPI+S+GSE+ L+QPV +
Sbjct: 560 FDSISHLINHHLESSLPIVSAGSELCLQQPVER 592
>gi|32261324 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 2 [Homo sapiens]
Length = 474
Score = 430 bits (1106), Expect = e-120
Identities = 246/452 (54%), Positives = 299/452 (66%), Gaps = 41/452 (9%)
Query: 185 LLGMGMNYCVRYMGCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIKKRKPPVK 244
++G G++Y VRYMGCVEVLQSMR+LDF RTQVTREAIS +CEAVPGA GA ++RKP +
Sbjct: 45 VMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSR 104
Query: 245 FLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGGDPDTTDYV 304
LS++LG+SNL+F+GM I LT+ST SL LM D +QIIANHHMQSISFASGGDPDT +YV
Sbjct: 105 PLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYV 164
Query: 305 AYVAKDPVNQRACHILECHNGMAQDVISTIGQAFELRFKQYLKNPSLNTSCESEEVHIDS 364
AYVAKDPVNQRACHILEC G+AQDVISTIGQAFELRFKQYL+NP + D
Sbjct: 165 AYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDG 224
Query: 365 HA-----EEREDHEYYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPIQCEKLCYLPGNSK 419
A EE DH+YYN+ PGK+PP+GGV DMR++ A PG ++
Sbjct: 225 SAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAA----------------PGAAR 268
Query: 420 CSSVYENCLEQSRAIGNVHPRGVQSQRDTSLLKH-----TCRV--DLFDDPCYINTQALQ 472
++ N S +G P G D + K C +LFDDP Y+N Q L
Sbjct: 269 PTA--PNAQTPSH-LGATLPVGQPVGGDPEVRKQMPPPPPCPAGRELFDDPSYVNVQNLD 325
Query: 473 STPGSAGNQRSAQPLGSPWHCGKAPE---TVQP--GATAQPASSHSLPHIKQQLWSEECY 527
+ G P + G AP ++P A P S+ + +QL E +
Sbjct: 326 KARQAVGGAGPPNPAIN----GSAPRDLFDMKPFEDALRVPPPPQSV-SMAEQLRGEPWF 380
Query: 528 HGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVF 587
HGKLSR+ AE+LL +GDFLVRES T+PGQYVL+GLQ GQ KHLLLVDPEG VRTKDH F
Sbjct: 381 HGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRF 440
Query: 588 DNVGHLIRYHMDNSLPIISSGSEVSLKQPVRK 619
++V HLI YHMDN LPIIS+GSE+ L+QPV +
Sbjct: 441 ESVSHLISYHMDNHLPIISAGSELCLQQPVER 472
>gi|194239668 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 4 [Homo sapiens]
Length = 473
Score = 429 bits (1104), Expect = e-120
Identities = 246/451 (54%), Positives = 299/451 (66%), Gaps = 40/451 (8%)
Query: 185 LLGMGMNYCVRYMGCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIKKRKPPVK 244
++G G++Y VRYMGCVEVLQSMR+LDF RTQVTREAIS +CEAVPGA GA ++RKP +
Sbjct: 45 VMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSR 104
Query: 245 FLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGGDPDTTDYV 304
LS++LG+SNL+F+GM I LT+ST SL LM D +QIIANHHMQSISFASGGDPDT +YV
Sbjct: 105 PLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYV 164
Query: 305 AYVAKDPVNQRACHILECHNGMAQDVISTIGQAFELRFKQYLKNPSLNTSCESEEVHIDS 364
AYVAKDPVNQRACHILEC G+AQDVISTIGQAFELRFKQYL+NP + D
Sbjct: 165 AYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDG 224
Query: 365 HA-----EEREDHEYYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPIQCEKLCYLPGNSK 419
A EE DH+YYN+ PGK+PP+GGV DMR++ A PG ++
Sbjct: 225 SAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAA----------------PGAAR 268
Query: 420 CSSVYENCLEQSRAIGNVHPRGVQSQRDTSLLKH-----TC-RVDLFDDPCYINTQALQS 473
++ N S +G P G D + K C +LFDDP Y+N Q L
Sbjct: 269 PTA--PNAQTPSH-LGATLPVGQPVGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDK 325
Query: 474 TPGSAGNQRSAQPLGSPWHCGKAPE---TVQP--GATAQPASSHSLPHIKQQLWSEECYH 528
+ G P + G AP ++P A P S+ + +QL E +H
Sbjct: 326 ARQAVGGAGPPNPAIN----GSAPRDLFDMKPFEDALRVPPPPQSV-SMAEQLRGEPWFH 380
Query: 529 GKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVFD 588
GKLSR+ AE+LL +GDFLVRES T+PGQYVL+GLQ GQ KHLLLVDPEG VRTKDH F+
Sbjct: 381 GKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFE 440
Query: 589 NVGHLIRYHMDNSLPIISSGSEVSLKQPVRK 619
+V HLI YHMDN LPIIS+GSE+ L+QPV +
Sbjct: 441 SVSHLISYHMDNHLPIISAGSELCLQQPVER 471
>gi|169790811 SHC (Src homology 2 domain containing) transforming
protein 2 [Homo sapiens]
Length = 582
Score = 374 bits (961), Expect = e-103
Identities = 243/619 (39%), Positives = 319/619 (51%), Gaps = 92/619 (14%)
Query: 51 GNKGSPQPPHPALAPHLPTEDATLPSQESPTPLCTLIPRMASMKLANPATLLSLKNFCLG 110
G + P PP P P E+PT C L+PRM K A P L
Sbjct: 6 GGRAPPAPPAP-------------PEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAA-- 50
Query: 111 TKEVPRLKLQESRDPGSSGPSSPETSLSRSGTAPPPQQDLVGHRATALTPDSCPLP---- 166
+R G+SG + P+ + G P ++G CPLP
Sbjct: 51 -----------ARAAGASGGADPQPEPAGPGGVPALAAAVLG-ACEPRCAAPCPLPALSR 98
Query: 167 ----------------GPGEPTLRSRQDR-------------HFLQHLLGMGMNYCVRYM 197
G G+ + R H +LG G++Y VRYM
Sbjct: 99 CRGAGSRGSRGGRGAAGSGDAAAAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRYM 158
Query: 198 GCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIKKRKPPVKFLSTVLGKSNLQF 257
GC+EVL+SMRSLDF RTQVTREAI+RL EAVPG G+ KK K P K L++VLGKSNL+F
Sbjct: 159 GCIEVLRSMRSLDFNTRTQVTREAINRLHEAVPGVRGSWKK-KAPNKALASVLGKSNLRF 217
Query: 258 SGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGGDPDTTDYVAYVAKDPVNQRAC 317
+GM+I + IST L+L +Q+IANHHM SISFASGGD D TDYVAYVAKDP+NQRAC
Sbjct: 218 AGMSISIHISTDGLSLSVPATRQVIANHHMPSISFASGGDTDMTDYVAYVAKDPINQRAC 277
Query: 318 HILECHNGMAQDVISTIGQAFELRFKQYLKNPSL----NTSCESEEVHIDSHAEEREDHE 373
HILEC G+AQ +IST+GQAFELRFKQYL +P E E+ +H
Sbjct: 278 HILECCEGLAQSIISTVGQAFELRFKQYLHSPPKVALPPERLAGPEESAWGDEEDSLEHN 337
Query: 374 YYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPI------QCEKLCYLP------GNSKCS 421
YYN IPGK+PP+GG+ D R+ + T+ A + C LP G +
Sbjct: 338 YYNSIPGKEPPLGGLVDSRLAL--TQPCALTALDQGPSPSLRDACSLPWDVGSTGTAPPG 395
Query: 422 SVYENCLEQSRAIGNVHPRGVQSQRDTSLLKHTCRVDLFDDPCYINTQALQSTPGSAGNQ 481
Y + H D + + + DLFD + + L +AG
Sbjct: 396 DGYVQADARGPPDHEEHLYVNTQGLDAPEPEDSPKKDLFDMRPFEDALKLHECSVAAGVT 455
Query: 482 RSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLLV 541
+ PL W + P + ++QL E YHG++SR+AAE +L
Sbjct: 456 AAPLPLEDQW-------------PSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLR 502
Query: 542 KDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDNS 601
DGDFLVR+S T+PGQYVL+G+ GQ KHLLLVDPEG VRTKD +F+++ HLI +H+ N
Sbjct: 503 ADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLIDHHLQNG 562
Query: 602 LPIISSGSEVSLKQPVRKD 620
PI+++ SE+ L+ V ++
Sbjct: 563 QPIVAAESELHLRGVVSRE 581
>gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo
sapiens]
Length = 475
Score = 127 bits (318), Expect = 4e-29
Identities = 68/163 (41%), Positives = 97/163 (59%), Gaps = 13/163 (7%)
Query: 458 DLFDDPCYINTQALQSTPGSAGNQRSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHI 517
DLFD + + L +AG + PL W + P +
Sbjct: 325 DLFDMRPFEDALKLHECSVAAGVTAAPLPLEDQW-------------PSPPTRRAPVAPT 371
Query: 518 KQQLWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPE 577
++QL E YHG++SR+AAE +L DGDFLVR+S T+PGQYVL+G+ GQ KHLLLVDPE
Sbjct: 372 EEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPE 431
Query: 578 GKVRTKDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRKD 620
G VRTKD +F+++ HLI +H+ N PI+++ SE+ L+ V ++
Sbjct: 432 GVVRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVSRE 474
Score = 48.9 bits (115), Expect = 1e-05
Identities = 22/28 (78%), Positives = 25/28 (89%)
Query: 196 YMGCVEVLQSMRSLDFGMRTQVTREAIS 223
YMGC+EVL+SMRSLDF RTQVTR+A S
Sbjct: 247 YMGCIEVLRSMRSLDFNTRTQVTRDACS 274
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 72.4 bits (176), Expect = 1e-12
Identities = 44/126 (34%), Positives = 64/126 (50%), Gaps = 1/126 (0%)
Query: 504 ATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGL 563
A A S + ++ L ++ YHG + R A+ LL K GDFLVRES PG+YVLS
Sbjct: 438 ALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSVY 497
Query: 564 QGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRKDNNP 623
GQ +H ++ + R + F N+ LI +H + +I+ S V L P+ KD
Sbjct: 498 SDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHY-TTKQVITKKSGVVLLNPIPKDKKW 556
Query: 624 ALLHSN 629
L H +
Sbjct: 557 ILSHED 562
>gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens]
Length = 825
Score = 58.5 bits (140), Expect = 2e-08
Identities = 37/110 (33%), Positives = 63/110 (57%), Gaps = 10/110 (9%)
Query: 519 QQLWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKH-------L 571
+ L S YHG++ R+ +E+L+ +DGDFLVR+S +SPG +VL+ A+H L
Sbjct: 147 EDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVL 206
Query: 572 LLVDPEGKVRTKDHV--FDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRK 619
L + +V+ + + FD++ L+R ++ N P IS S + QP+ +
Sbjct: 207 RLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRP-ISQQSGAIIFQPINR 255
>gi|242247193 SH2B adaptor protein 2 [Homo sapiens]
Length = 675
Score = 57.8 bits (138), Expect = 3e-08
Identities = 46/147 (31%), Positives = 75/147 (51%), Gaps = 13/147 (8%)
Query: 485 QPLGSPWHCGK-APETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLLVKD 543
Q L SP G + T + GA P + L +L +HG LSR A L++
Sbjct: 423 QTLESPGGSGSDSNNTGEQGAETDPEAEPEL-----ELSDYPWFHGTLSRVKAAQLVLAG 477
Query: 544 GD-----FLVRESATSPGQYVLSGLQGGQAKHL-LLVDPEGKVRTKDHVFDNVGHLIRYH 597
G F++R+S T PG+YVL+ G+AKHL L ++ G+ + F +V ++R+
Sbjct: 478 GPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLDMLRHF 537
Query: 598 MDNSLPIISSGS-EVSLKQPVRKDNNP 623
+ +P+ S GS +++L+ VR + P
Sbjct: 538 HTHPIPLESGGSADITLRSYVRAQDPP 564
>gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens]
Length = 700
Score = 55.8 bits (133), Expect = 1e-07
Identities = 38/108 (35%), Positives = 58/108 (53%), Gaps = 10/108 (9%)
Query: 521 LWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLL---VDPE 577
L S YHG++ R+ +E+L+ ++GDFL+R+S TS G YVL+ QA H + V
Sbjct: 55 LRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKA 114
Query: 578 GKVRT------KDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRK 619
G+ T + FD+V L+RYH+ S +S S + PV +
Sbjct: 115 GESYTHIQYLFEQESFDHVPALVRYHV-GSRKAVSEQSGAIIYCPVNR 161
>gi|216547790 SH2 domain containing 3C isoform d [Homo sapiens]
Length = 702
Score = 55.8 bits (133), Expect = 1e-07
Identities = 38/108 (35%), Positives = 58/108 (53%), Gaps = 10/108 (9%)
Query: 521 LWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLL---VDPE 577
L S YHG++ R+ +E+L+ ++GDFL+R+S TS G YVL+ QA H + V
Sbjct: 57 LRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKA 116
Query: 578 GKVRT------KDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRK 619
G+ T + FD+V L+RYH+ S +S S + PV +
Sbjct: 117 GESYTHIQYLFEQESFDHVPALVRYHV-GSRKAVSEQSGAIIYCPVNR 163
>gi|216547763 SH2 domain containing 3C isoform b [Homo sapiens]
Length = 703
Score = 55.8 bits (133), Expect = 1e-07
Identities = 38/108 (35%), Positives = 58/108 (53%), Gaps = 10/108 (9%)
Query: 521 LWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLL---VDPE 577
L S YHG++ R+ +E+L+ ++GDFL+R+S TS G YVL+ QA H + V
Sbjct: 58 LRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKA 117
Query: 578 GKVRT------KDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRK 619
G+ T + FD+V L+RYH+ S +S S + PV +
Sbjct: 118 GESYTHIQYLFEQESFDHVPALVRYHV-GSRKAVSEQSGAIIYCPVNR 164
>gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens]
Length = 860
Score = 55.8 bits (133), Expect = 1e-07
Identities = 38/108 (35%), Positives = 58/108 (53%), Gaps = 10/108 (9%)
Query: 521 LWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLL---VDPE 577
L S YHG++ R+ +E+L+ ++GDFL+R+S TS G YVL+ QA H + V
Sbjct: 215 LRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKA 274
Query: 578 GKVRT------KDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRK 619
G+ T + FD+V L+RYH+ S +S S + PV +
Sbjct: 275 GESYTHIQYLFEQESFDHVPALVRYHV-GSRKAVSEQSGAIIYCPVNR 321
>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
Length = 764
Score = 53.5 bits (127), Expect = 6e-07
Identities = 36/113 (31%), Positives = 55/113 (48%), Gaps = 2/113 (1%)
Query: 508 PASSHSLPHIKQQLWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQ 567
P +P +++ L + YHG + R LLV GDFLVRES +YVLS L G
Sbjct: 384 PPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRES-QGKQEYVLSVLWDGL 442
Query: 568 AKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRKD 620
+H ++ + R + F ++ LI + + P ++ S V L + V KD
Sbjct: 443 PRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQP-LTKKSGVVLHRAVPKD 494
>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
Length = 822
Score = 53.5 bits (127), Expect = 6e-07
Identities = 36/113 (31%), Positives = 55/113 (48%), Gaps = 2/113 (1%)
Query: 508 PASSHSLPHIKQQLWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQ 567
P +P +++ L + YHG + R LLV GDFLVRES +YVLS L G
Sbjct: 442 PPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRES-QGKQEYVLSVLWDGL 500
Query: 568 AKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRKD 620
+H ++ + R + F ++ LI + + P ++ S V L + V KD
Sbjct: 501 PRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQP-LTKKSGVVLHRAVPKD 552
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 52.4 bits (124), Expect = 1e-06
Identities = 37/103 (35%), Positives = 52/103 (50%), Gaps = 9/103 (8%)
Query: 527 YHGKLSRKAAESLLVK--DGDFLVRESATSPGQYVLSGLQGGQAKHLLL-VDPEGKVR-T 582
YHG +SR AAE LL +G FLVRES +SPGQ +S G+ H + +GKV T
Sbjct: 159 YHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVT 218
Query: 583 KDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRKDNNPAL 625
+ F + L+ +H ++ G +L P K N P +
Sbjct: 219 AESRFSTLAELVHHH-----STVADGLVTTLHYPAPKCNKPTV 256
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 52.4 bits (124), Expect = 1e-06
Identities = 37/103 (35%), Positives = 52/103 (50%), Gaps = 9/103 (8%)
Query: 527 YHGKLSRKAAESLLVK--DGDFLVRESATSPGQYVLSGLQGGQAKHLLL-VDPEGKVR-T 582
YHG +SR AAE LL +G FLVRES +SPGQ +S G+ H + +GKV T
Sbjct: 174 YHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVT 233
Query: 583 KDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRKDNNPAL 625
+ F + L+ +H ++ G +L P K N P +
Sbjct: 234 AESRFSTLAELVHHH-----STVADGLVTTLHYPAPKCNKPTV 271
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 52.4 bits (124), Expect = 1e-06
Identities = 37/103 (35%), Positives = 52/103 (50%), Gaps = 9/103 (8%)
Query: 527 YHGKLSRKAAESLLVK--DGDFLVRESATSPGQYVLSGLQGGQAKHLLL-VDPEGKVR-T 582
YHG +SR AAE LL +G FLVRES +SPGQ +S G+ H + +GKV T
Sbjct: 153 YHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVT 212
Query: 583 KDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRKDNNPAL 625
+ F + L+ +H ++ G +L P K N P +
Sbjct: 213 AESRFSTLAELVHHH-----STVADGLVTTLHYPAPKCNKPTV 250
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 52.4 bits (124), Expect = 1e-06
Identities = 37/103 (35%), Positives = 52/103 (50%), Gaps = 9/103 (8%)
Query: 527 YHGKLSRKAAESLLVK--DGDFLVRESATSPGQYVLSGLQGGQAKHLLL-VDPEGKVR-T 582
YHG +SR AAE LL +G FLVRES +SPGQ +S G+ H + +GKV T
Sbjct: 159 YHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVT 218
Query: 583 KDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRKDNNPAL 625
+ F + L+ +H ++ G +L P K N P +
Sbjct: 219 AESRFSTLAELVHHH-----STVADGLVTTLHYPAPKCNKPTV 256
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 52.4 bits (124), Expect = 1e-06
Identities = 37/103 (35%), Positives = 52/103 (50%), Gaps = 9/103 (8%)
Query: 527 YHGKLSRKAAESLLVK--DGDFLVRESATSPGQYVLSGLQGGQAKHLLL-VDPEGKVR-T 582
YHG +SR AAE LL +G FLVRES +SPGQ +S G+ H + +GKV T
Sbjct: 138 YHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVT 197
Query: 583 KDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRKDNNPAL 625
+ F + L+ +H ++ G +L P K N P +
Sbjct: 198 AESRFSTLAELVHHH-----STVADGLVTTLHYPAPKCNKPTV 235
>gi|224926826 SH2B adaptor protein 1 isoform 1 [Homo sapiens]
Length = 756
Score = 52.4 bits (124), Expect = 1e-06
Identities = 45/157 (28%), Positives = 70/157 (44%), Gaps = 16/157 (10%)
Query: 483 SAQPLGSPWHCGKAPETVQPGATAQ--PASSHSLPHIKQQLWSEECYHGKLSRKAAESLL 540
+ PL +P+ PET Q P + W +HG LSR A L+
Sbjct: 486 TVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPW----FHGMLSRLKAAQLV 541
Query: 541 VKDGD-----FLVRESATSPGQYVLSGLQGGQAKHL-LLVDPEGKVRTKDHVFDNVGHLI 594
+ G FLVR+S T G+YVL+ G+AKHL L ++ EG+ R + F ++ ++
Sbjct: 542 LTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDML 601
Query: 595 RYHMDNSLPIISSGSE----VSLKQPVRKDNNPALLH 627
+ + +P+ S GS VS ++ P H
Sbjct: 602 EHFRVHPIPLESGGSSDVVLVSYVPSSQRQQEPTTSH 638
>gi|224926824 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
Length = 671
Score = 52.0 bits (123), Expect = 2e-06
Identities = 41/135 (30%), Positives = 64/135 (47%), Gaps = 12/135 (8%)
Query: 483 SAQPLGSPWHCGKAPETVQPGATAQ--PASSHSLPHIKQQLWSEECYHGKLSRKAAESLL 540
+ PL +P+ PET Q P + W +HG LSR A L+
Sbjct: 486 TVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPW----FHGMLSRLKAAQLV 541
Query: 541 VKDGD-----FLVRESATSPGQYVLSGLQGGQAKHL-LLVDPEGKVRTKDHVFDNVGHLI 594
+ G FLVR+S T G+YVL+ G+AKHL L ++ EG+ R + F ++ ++
Sbjct: 542 LTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDML 601
Query: 595 RYHMDNSLPIISSGS 609
+ + +P+ S GS
Sbjct: 602 EHFRVHPIPLESGGS 616
>gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens]
Length = 683
Score = 52.0 bits (123), Expect = 2e-06
Identities = 41/135 (30%), Positives = 64/135 (47%), Gaps = 12/135 (8%)
Query: 483 SAQPLGSPWHCGKAPETVQPGATAQ--PASSHSLPHIKQQLWSEECYHGKLSRKAAESLL 540
+ PL +P+ PET Q P + W +HG LSR A L+
Sbjct: 486 TVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPW----FHGMLSRLKAAQLV 541
Query: 541 VKDGD-----FLVRESATSPGQYVLSGLQGGQAKHL-LLVDPEGKVRTKDHVFDNVGHLI 594
+ G FLVR+S T G+YVL+ G+AKHL L ++ EG+ R + F ++ ++
Sbjct: 542 LTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDML 601
Query: 595 RYHMDNSLPIISSGS 609
+ + +P+ S GS
Sbjct: 602 EHFRVHPIPLESGGS 616
>gi|224926828 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
Length = 671
Score = 52.0 bits (123), Expect = 2e-06
Identities = 41/135 (30%), Positives = 64/135 (47%), Gaps = 12/135 (8%)
Query: 483 SAQPLGSPWHCGKAPETVQPGATAQ--PASSHSLPHIKQQLWSEECYHGKLSRKAAESLL 540
+ PL +P+ PET Q P + W +HG LSR A L+
Sbjct: 486 TVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPW----FHGMLSRLKAAQLV 541
Query: 541 VKDGD-----FLVRESATSPGQYVLSGLQGGQAKHL-LLVDPEGKVRTKDHVFDNVGHLI 594
+ G FLVR+S T G+YVL+ G+AKHL L ++ EG+ R + F ++ ++
Sbjct: 542 LTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDML 601
Query: 595 RYHMDNSLPIISSGS 609
+ + +P+ S GS
Sbjct: 602 EHFRVHPIPLESGGS 616
>gi|224926822 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
Length = 671
Score = 52.0 bits (123), Expect = 2e-06
Identities = 41/135 (30%), Positives = 64/135 (47%), Gaps = 12/135 (8%)
Query: 483 SAQPLGSPWHCGKAPETVQPGATAQ--PASSHSLPHIKQQLWSEECYHGKLSRKAAESLL 540
+ PL +P+ PET Q P + W +HG LSR A L+
Sbjct: 486 TVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPW----FHGMLSRLKAAQLV 541
Query: 541 VKDGD-----FLVRESATSPGQYVLSGLQGGQAKHL-LLVDPEGKVRTKDHVFDNVGHLI 594
+ G FLVR+S T G+YVL+ G+AKHL L ++ EG+ R + F ++ ++
Sbjct: 542 LTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDML 601
Query: 595 RYHMDNSLPIISSGS 609
+ + +P+ S GS
Sbjct: 602 EHFRVHPIPLESGGS 616
>gi|22035548 amyloid beta A4 precursor protein-binding, family A,
member 1 [Homo sapiens]
Length = 837
Score = 52.0 bits (123), Expect = 2e-06
Identities = 60/262 (22%), Positives = 112/262 (42%), Gaps = 47/262 (17%)
Query: 121 ESRDPGSSGPSSPETSLSRSGTAPPPQQDL--VGHRATALTPDSCPLPGPGEPTLRSRQD 178
+S PGSS P E+S + + P + ++ A P +PGP +P
Sbjct: 400 DSPSPGSSSPLGAESSSTSLHPSDPVEASTNKESRKSLASFPTYVEVPGPCDP------- 452
Query: 179 RHFLQHLLGMGMNYCVRYMGCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIKK 238
+ L+ G+ + Y+G ++L S ++ +R +EA+SR+ A A +K
Sbjct: 453 ----EDLID-GIIFAANYLGSTQLL-SDKTPSKNVRMMQAQEAVSRIKMAQKLAKS--RK 504
Query: 239 RKPPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISF------ 292
+ P G+S + L IST + ++N D Q+ + +H +++IS+
Sbjct: 505 KAPE--------GESQPM---TEVDLFISTQRIKVLNADTQETMMDHPLRTISYIADIGN 553
Query: 293 -----ASGGDPDTTDYVAYVAKDPVN------QRACHILECHNGMAQDVISTIGQAFELR 341
A P + A P + CH+ E + AQ + +IGQAF +
Sbjct: 554 IVVLMARRRMPRSNSQENVEASHPSQDGKRQYKMICHVFESED--AQLIAQSIGQAFSVA 611
Query: 342 FKQYLKNPSLNTSCESEEVHID 363
++++L+ +N S++ + D
Sbjct: 612 YQEFLRANGINPEDLSQKEYSD 633
>gi|106879210 Src homology 2 domain containing adaptor protein B
[Homo sapiens]
Length = 509
Score = 52.0 bits (123), Expect = 2e-06
Identities = 44/134 (32%), Positives = 59/134 (44%), Gaps = 20/134 (14%)
Query: 488 GSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESL--LVKDGD 545
GSP CG E V P +++Q+W YHG +SR AE+L L K+
Sbjct: 387 GSPEFCGILGERVDPAVP-----------LEKQIW----YHGAISRGDAENLLRLCKECS 431
Query: 546 FLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGK--VRTKDHVFDNVGHLIRYHMDNSLP 603
+LVR S TS Y LS H+ L + K + FD+V +I Y+ LP
Sbjct: 432 YLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKEKYVLGQNSPPFDSVPEVIHYYTTRKLP 491
Query: 604 IISSGSEVSLKQPV 617
I +SL PV
Sbjct: 492 -IKGAEHLSLLYPV 504
>gi|111074524 Src homology 2 domain containing F [Homo sapiens]
Length = 423
Score = 51.6 bits (122), Expect = 2e-06
Identities = 46/152 (30%), Positives = 70/152 (46%), Gaps = 34/152 (22%)
Query: 477 SAGNQRSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAA 536
SAGN +SA+PL +++P + + +LP ++ Q+W YHG +SR A
Sbjct: 290 SAGNPKSAKPL-----------SMEPSSPLGEWTDPALP-LENQVW----YHGAISRTDA 333
Query: 537 ESL--LVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDH--------- 585
E+L L K+ +LVR S TS + LS H+ L RTK+H
Sbjct: 334 ENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL------SRTKEHKYVLGQNSP 387
Query: 586 VFDNVGHLIRYHMDNSLPIISSGSEVSLKQPV 617
F +V ++ ++ LP I +SL PV
Sbjct: 388 PFSSVPEIVHHYASRKLP-IKGAEHMSLLYPV 418
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,540,029
Number of Sequences: 37866
Number of extensions: 1497394
Number of successful extensions: 8338
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 61
Number of HSP's successfully gapped in prelim test: 249
Number of HSP's that attempted gapping in prelim test: 7826
Number of HSP's gapped (non-prelim): 682
length of query: 630
length of database: 18,247,518
effective HSP length: 108
effective length of query: 522
effective length of database: 14,157,990
effective search space: 7390470780
effective search space used: 7390470780
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.