Guide to the Human Genome
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Search of human proteins with 221316705

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|221316705 NADPH dependent diflavin oxidoreductase 1 isoform
a [Homo sapiens]
         (606 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|221316705 NADPH dependent diflavin oxidoreductase 1 isoform a...  1234   0.0  
gi|7657393 NADPH dependent diflavin oxidoreductase 1 isoform b [...  1209   0.0  
gi|221316709 NADPH dependent diflavin oxidoreductase 1 isoform c...  1187   0.0  
gi|221316707 NADPH dependent diflavin oxidoreductase 1 isoform d...  1006   0.0  
gi|127139033 cytochrome P450 reductase [Homo sapiens]                 284   1e-76
gi|40254422 nitric oxide synthase 3 isoform 1 [Homo sapiens]          194   2e-49
gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]          188   1e-47
gi|24041029 nitric oxide synthase 2A [Homo sapiens]                   187   3e-47
gi|169790958 methionine synthase reductase isoform 1 [Homo sapiens]   181   2e-45
gi|169790956 methionine synthase reductase isoform 2 [Homo sapiens]   181   2e-45
gi|231571329 nitric oxide synthase 3 isoform 3 [Homo sapiens]          60   8e-09
gi|231571356 nitric oxide synthase 3 isoform 4 [Homo sapiens]          57   4e-08
gi|231571314 nitric oxide synthase 3 isoform 2 [Homo sapiens]          57   4e-08
gi|50726981 radical S-adenosyl methionine and flavodoxin domains...    47   5e-05
gi|18959210 WIRE protein [Homo sapiens]                                38   0.024
gi|224282123 tRNA-yW synthesizing protein 1 homolog B isoform 1 ...    35   0.20 
gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [...    35   0.20 
gi|221139926 NHS-like 1 [Homo sapiens]                                 34   0.34 
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap...    34   0.34 
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap...    34   0.34 
gi|27312029 hypothetical protein LOC145376 [Homo sapiens]              33   0.58 
gi|145587088 hypothetical protein LOC165186 [Homo sapiens]             33   0.99 
gi|239753314 PREDICTED: similar to RIKEN cDNA C230030N03 [Homo s...    31   2.9  
gi|151301053 RNA binding motif protein 33 [Homo sapiens]               31   2.9  
gi|68161504 Wiskott-Aldrich syndrome protein family member 1 [Ho...    31   3.8  
gi|68161502 Wiskott-Aldrich syndrome protein family member 1 [Ho...    31   3.8  
gi|68161500 Wiskott-Aldrich syndrome protein family member 1 [Ho...    31   3.8  
gi|4507913 Wiskott-Aldrich syndrome protein family member 1 [Hom...    31   3.8  
gi|239757699 PREDICTED: hypothetical protein [Homo sapiens]            31   3.8  
gi|239756047 PREDICTED: heparan sulfate 6-O-sulfotransferase 3 [...    31   3.8  

>gi|221316705 NADPH dependent diflavin oxidoreductase 1 isoform a
           [Homo sapiens]
          Length = 606

 Score = 1234 bits (3192), Expect = 0.0
 Identities = 606/606 (100%), Positives = 606/606 (100%)

Query: 1   MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 60
           MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT
Sbjct: 1   MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 60

Query: 61  TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120
           TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG
Sbjct: 61  TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120

Query: 121 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 180
           GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF
Sbjct: 121 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 180

Query: 181 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 240
           LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI
Sbjct: 181 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 240

Query: 241 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 300
           SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS
Sbjct: 241 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 300

Query: 301 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 360
           HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF
Sbjct: 301 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 360

Query: 361 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 420
           PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS
Sbjct: 361 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 420

Query: 421 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 480
           WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN
Sbjct: 421 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 480

Query: 481 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQPPALFSALQEQKVYVQHRLREL 540
           FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQPPALFSALQEQKVYVQHRLREL
Sbjct: 481 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQPPALFSALQEQKVYVQHRLREL 540

Query: 541 GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF 600
           GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF
Sbjct: 541 GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF 600

Query: 601 QTETWA 606
           QTETWA
Sbjct: 601 QTETWA 606


>gi|7657393 NADPH dependent diflavin oxidoreductase 1 isoform b
           [Homo sapiens]
          Length = 597

 Score = 1209 bits (3127), Expect = 0.0
 Identities = 597/606 (98%), Positives = 597/606 (98%), Gaps = 9/606 (1%)

Query: 1   MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 60
           MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT
Sbjct: 1   MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 60

Query: 61  TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120
           TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG
Sbjct: 61  TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120

Query: 121 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 180
           GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF
Sbjct: 121 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 180

Query: 181 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 240
           LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI
Sbjct: 181 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 240

Query: 241 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 300
           SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS
Sbjct: 241 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 300

Query: 301 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 360
           HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF
Sbjct: 301 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 360

Query: 361 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 420
           PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS
Sbjct: 361 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 420

Query: 421 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 480
           WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN
Sbjct: 421 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 480

Query: 481 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQPPALFSALQEQKVYVQHRLREL 540
           FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSRE         QEQKVYVQHRLREL
Sbjct: 481 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSRE---------QEQKVYVQHRLREL 531

Query: 541 GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF 600
           GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF
Sbjct: 532 GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF 591

Query: 601 QTETWA 606
           QTETWA
Sbjct: 592 QTETWA 597


>gi|221316709 NADPH dependent diflavin oxidoreductase 1 isoform c
           [Homo sapiens]
          Length = 590

 Score = 1187 bits (3071), Expect = 0.0
 Identities = 590/606 (97%), Positives = 590/606 (97%), Gaps = 16/606 (2%)

Query: 1   MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 60
           MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT
Sbjct: 1   MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 60

Query: 61  TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120
           TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG
Sbjct: 61  TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120

Query: 121 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 180
           GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF
Sbjct: 121 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 180

Query: 181 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 240
           LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI
Sbjct: 181 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 240

Query: 241 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 300
           SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS
Sbjct: 241 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 300

Query: 301 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 360
           HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF
Sbjct: 301 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 360

Query: 361 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 420
           PHTAAAIPPDYLLDLIPVIRPRAFSIASSLL       ILVAVVQFQTRLKEPRRGLCSS
Sbjct: 361 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLL-------ILVAVVQFQTRLKEPRRGLCSS 413

Query: 421 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 480
           WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN
Sbjct: 414 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 473

Query: 481 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQPPALFSALQEQKVYVQHRLREL 540
           FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSRE         QEQKVYVQHRLREL
Sbjct: 474 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSRE---------QEQKVYVQHRLREL 524

Query: 541 GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF 600
           GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF
Sbjct: 525 GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF 584

Query: 601 QTETWA 606
           QTETWA
Sbjct: 585 QTETWA 590


>gi|221316707 NADPH dependent diflavin oxidoreductase 1 isoform d
           [Homo sapiens]
          Length = 521

 Score = 1006 bits (2600), Expect = 0.0
 Identities = 508/551 (92%), Positives = 508/551 (92%), Gaps = 43/551 (7%)

Query: 1   MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 60
           MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT
Sbjct: 1   MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 60

Query: 61  TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120
           TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG
Sbjct: 61  TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120

Query: 121 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 180
           GSALLPVCLGDDQHELG                                  LPSKFTLLF
Sbjct: 121 GSALLPVCLGDDQHELG----------------------------------LPSKFTLLF 146

Query: 181 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 240
           LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI
Sbjct: 147 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 206

Query: 241 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 300
           SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS
Sbjct: 207 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 266

Query: 301 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 360
           HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF
Sbjct: 267 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 326

Query: 361 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 420
           PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS
Sbjct: 327 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 386

Query: 421 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 480
           WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN
Sbjct: 387 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 446

Query: 481 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQPPALFSALQEQKVYVQHRLREL 540
           FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSRE         QEQKVYVQHRLREL
Sbjct: 447 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSRE---------QEQKVYVQHRLREL 497

Query: 541 GSLVWELLDRQ 551
           GSLVWELLDRQ
Sbjct: 498 GSLVWELLDRQ 508


>gi|127139033 cytochrome P450 reductase [Homo sapiens]
          Length = 680

 Score =  284 bits (727), Expect = 1e-76
 Identities = 197/618 (31%), Positives = 313/618 (50%), Gaps = 37/618 (5%)

Query: 6   LLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNL-----INEPLVIFVCAT 60
           ++V +GSQTGTA++ + RL ++A R  +       + Y + +L     I+  LV+F  AT
Sbjct: 83  IIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMAT 142

Query: 61  TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120
            G+GDP DN ++F+ ++   ++    L  + FAV GLG+ +Y  FN + K + +RL QLG
Sbjct: 143 YGEGDPTDNAQDFYDWLQETDVD---LSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLG 199

Query: 121 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 180
              +  + LGDD   L  D     W    W  V   +      T     +          
Sbjct: 200 AQRIFELGLGDDDGNLEEDFIT--WREQFWPAVCEHFGVEA--TGEESSIRQYELVVHTD 255

Query: 181 LQEAPSTGSEGQRVAHPGSQEPPSESK-PFLAPMISNQRVTGPSHFQDVRLIEFDILGSG 239
           +  A     E  R+    +Q+PP ++K PFLA + +N+++   +  + +  +E DI  S 
Sbjct: 256 IDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTE-RHLMHLELDISDSK 314

Query: 240 ISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLV 299
           I + +GD V + P+N +A V +  ++LG D D +  L   + + +     P P S R  +
Sbjct: 315 IRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHPFPCPTSYRTAL 374

Query: 300 SHYLDIASVPRRSFFELLACLSLHELEREKL--LEFSSAQGQEELFEYCNRPRRTILEVL 357
           ++YLDI + PR +    LA  +    E+E L  +  SS +G+E    +    RR IL +L
Sbjct: 375 TYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAIL 434

Query: 358 CDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGL 417
            D P  +   P D+L +L+P ++ R +SIASS   HP+ + I   VV+++T+     +G+
Sbjct: 435 QDCP--SLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGV 492

Query: 418 CSSWLASLDP---GQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVA 474
            ++WL + +P     G   VP++VR      P    TPVIMVGPGTGVAPF   IQER  
Sbjct: 493 ATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAW 552

Query: 475 QGQTG-----NFLFFGCRWRDQDFYWEAEWQELEKRDCLT-LIPAFSREQPPALFSALQE 528
             Q G       L++GCR  D+D+ +  E  +  +   LT L  AFSRE         Q 
Sbjct: 553 LRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSRE---------QS 603

Query: 529 QKVYVQHRLRELGSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAA 588
            KVYVQH L++    +W+L++  GA+ Y+ G+A++M  DV      I  E G +    A 
Sbjct: 604 HKVYVQHLLKQDREHLWKLIE-GGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAV 662

Query: 589 AYLARLQQTRRFQTETWA 606
            Y+ +L    R+  + W+
Sbjct: 663 DYIKKLMTKGRYSLDVWS 680


>gi|40254422 nitric oxide synthase 3 isoform 1 [Homo sapiens]
          Length = 1203

 Score =  194 bits (493), Expect = 2e-49
 Identities = 187/663 (28%), Positives = 299/663 (45%), Gaps = 93/663 (14%)

Query: 8    VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67
            +L+GS+TG AQ  +++LGR   R+    RV  +D Y VV+L +E LV+ V +T G GDPP
Sbjct: 522  ILYGSETGRAQSYAQQLGR-LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPP 580

Query: 68   DNMKNF---------------------------------------WRFIFRKNLPST--- 85
            +N ++F                                       WR   RK   S+   
Sbjct: 581  ENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSISCSDPLVSSWR---RKRKESSNTD 637

Query: 86   ---ALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGPDAAV 142
               AL  + F V GLG  +Y  F   A+ +  RL +LGG  LL +  GD+    G + A 
Sbjct: 638  SAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDEL--CGQEEAF 695

Query: 143  DPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEP 202
              W +  +      +            +  P + +    +   S  +EG ++  PG    
Sbjct: 696  RGWAQAAFQAACETFCVGEDAKAAARDIFSPKR-SWKRQRYRLSAQAEGLQLL-PGLIHV 753

Query: 203  PSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGS-GISFAAGDVVLIQPSNSAAHVQR 261
                K F A + S + +      +   L+  D  G  G+ +  GD + + P N    V+ 
Sbjct: 754  -HRRKMFQATIRSVENLQSSKSTRATILVRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEA 812

Query: 262  FCQVLG-----LDPDQLFMLQPREPDVSSP-----TRLPQPCSMRHLVSHYLDIASVPRR 311
                +       +P  +  L+   P    P      RLP PC++R  ++ +LDI S P  
Sbjct: 813  LLSRVEDPPAPTEPVAVEQLEKGSPGGPPPGWVRDPRLP-PCTLRQALTFFLDITSPPSP 871

Query: 312  SFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPDY 371
                LL+ L+    E+++L   S    + E +++   P  T+LEVL  FP  + A+P   
Sbjct: 872  QLLRLLSTLAEEPREQQELEALSQDPRRYEEWKWFRCP--TLLEVLEQFP--SVALPAPL 927

Query: 372  LLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTR--LKEPRRGLCSSWLASLDPGQ 429
            LL  +P+++PR +S++S+  THP  + + VAV+ ++T+  L     G+CS+WL+ L PG 
Sbjct: 928  LLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAVLAYRTQDGLGPLHYGVCSTWLSQLKPGD 987

Query: 430  GPVRVPLWVRPG-SLAFPETPDTPVIMVGPGTGVAPFRAAIQERV----AQG--QTGNFL 482
                VP ++R   S   P  P  P I+VGPGTG+APFR   QER+    ++G   T   L
Sbjct: 988  P---VPCFIRGAPSFRLPPDPSLPCILVGPGTGIAPFRGFWQERLHDIESKGLQPTPMTL 1044

Query: 483  FFGCRWRDQDFYWEAEWQELEKRDCL-TLIPAFSREQPPALFSALQEQKVYVQHRLR-EL 540
             FGCR    D  +  E Q  ++R     ++ AFSRE            K YVQ  LR EL
Sbjct: 1045 VFGCRCSQLDHLYRDEVQNAQQRGVFGRVLTAFSREP--------DNPKTYVQDILRTEL 1096

Query: 541  GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF 600
             + V  +L  +  + ++ G+  +M  +V + +  I   EG +   +A   +  L+  +R+
Sbjct: 1097 AAEVHRVLCLERGHMFVCGDV-TMATNVLQTVQRILATEGDMELDEAGDVIGVLRDQQRY 1155

Query: 601  QTE 603
              +
Sbjct: 1156 HED 1158


>gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]
          Length = 1434

 Score =  188 bits (477), Expect = 1e-47
 Identities = 178/666 (26%), Positives = 292/666 (43%), Gaps = 99/666 (14%)

Query: 8    VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67
            +L+ ++TG +Q  ++ L  E  +     +V +++ Y +V+L +E LV+ V +T G GDPP
Sbjct: 762  ILYATETGKSQAYAKTLC-EIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPP 820

Query: 68   DNMKNFWRFIFRKNLPSTA---------------------------------------LC 88
            +N + F   +     P++                                        L 
Sbjct: 821  ENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLA 880

Query: 89   QMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGPDAAVDPWLRD 148
             + F+V GLG  +Y  F      +   L +LGG  +L +  GD+    G + A   W + 
Sbjct: 881  NVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDEL--CGQEEAFRTWAKK 938

Query: 149  LWDRVLGLYPPPPGLTEIPPGVPLPS--------KFTLLFLQEAPSTGSEGQRVAHPGSQ 200
            ++     ++     +        L S        KF L F+ EAP   ++G    H    
Sbjct: 939  VFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPEL-TQGLSNVH---- 993

Query: 201  EPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSG-ISFAAGDVVLIQPSNSAAHV 259
                + +   A ++S Q +  P   +    +     GS  + +  GD + + P N    V
Sbjct: 994  ----KKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLV 1049

Query: 260  QRFCQVLGLDPD-----QLFMLQPREPDV------SSPTRLPQPCSMRHLVSHYLDIASV 308
                + L   P      ++ +L+ R   +      +   RLP PC++     +YLDI + 
Sbjct: 1050 NALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLP-PCTIFQAFKYYLDITTP 1108

Query: 309  PRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIP 368
            P     +  A L+  E E+++LL  S    + E +++   P  TI+EVL +FP  +  +P
Sbjct: 1109 PTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNP--TIVEVLEEFP--SIQMP 1164

Query: 369  PDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEP--RRGLCSSWLASLD 426
               LL  + +++PR +SI+SS   +P  + + VA+V ++TR  E     G+CSSWL  + 
Sbjct: 1165 ATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRI- 1223

Query: 427  PGQGPVRVPLWVRPG-SLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGNF---- 481
              Q    VP +VR   S   P  P  P I+VGPGTG+APFR+  Q+R    Q        
Sbjct: 1224 --QADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCP 1281

Query: 482  --LFFGCRWRDQD-FYWEAEWQELEKRDCLTLIPAFSREQPPALFSALQEQKVYVQHRLR 538
              L FGCR    D  Y E   Q   K     L  A+SRE          + K YVQ  L+
Sbjct: 1282 MVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREP--------DKPKKYVQDILQ 1333

Query: 539  E-LGSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQT 597
            E L   V+  L  QG + Y+ G+  +M ADV +A+  I  ++G L + DA  +++R++  
Sbjct: 1334 EQLAESVYRALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSAEDAGVFISRMRDD 1392

Query: 598  RRFQTE 603
             R+  +
Sbjct: 1393 NRYHED 1398


>gi|24041029 nitric oxide synthase 2A [Homo sapiens]
          Length = 1153

 Score =  187 bits (474), Expect = 3e-47
 Identities = 175/623 (28%), Positives = 292/623 (46%), Gaps = 58/623 (9%)

Query: 5    QLLVLFGSQTGTAQDVSERLGREARRRRLGC----RVQALDSYPVVNLINEPLVIFVCAT 60
            ++ +LF ++TG ++ ++  LG         C    +V  +D Y +  L  E L++ V +T
Sbjct: 538  RVTILFATETGKSEALAWDLGA-----LFSCAFNPKVVCMDKYRLSCLEEERLLLVVTST 592

Query: 61   TGQGDPPDNMKNFWRFIFR-KNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQL 119
             G GD P N +   + +F  K L +    +  +AV GLG S Y +F   A  + ++L  L
Sbjct: 593  FGNGDCPGNGEKLKKSLFMLKELNN----KFRYAVFGLGSSMYPRFCAFAHDIDQKLSHL 648

Query: 120  GGSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFT-- 177
            G S L P+  GD+    G + A   W    +      +            + +P  +T  
Sbjct: 649  GASQLTPMGEGDELS--GQEDAFRSWAVQTFKAACETFD-----VRGKQHIQIPKLYTSN 701

Query: 178  LLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDIL- 236
            + +         + Q +    +         F   + S Q +  P+  +   L+E     
Sbjct: 702  VTWDPHHYRLVQDSQPLDLSKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCED 761

Query: 237  GSGISFAAGDVVLIQPSNSAAHVQRFCQ--VLGLDPDQLFMLQPREPDVS---SPTRLPQ 291
            G G+++  G+ + + P N  A VQ   +  V G  P Q   L+  +   S   S  RLP 
Sbjct: 762  GQGLNYLPGEHLGVCPGNQPALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLP- 820

Query: 292  PCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRR 351
            PCS+   ++++LDI + P +   + LA ++  E ER++L E      +   +++ N P  
Sbjct: 821  PCSLSQALTYFLDITTPPTQLLLQKLAQVATEEPERQRL-EALCQPSEYSKWKFTNSP-- 877

Query: 352  TILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLK 411
            T LEVL +FP  +  +   +LL  +P+++PR +SI+SS    P+ + + VAVV + TR  
Sbjct: 878  TFLEVLEEFP--SLRVSAGFLLSQLPILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDG 935

Query: 412  EP--RRGLCSSWLASLDPGQGPVRVPLWVRPGS-LAFPETPDTPVIMVGPGTGVAPFRAA 468
            +     G+CS+WL SL P Q PV  P +VR  S    PE P  P I++GPGTG+APFR+ 
Sbjct: 936  QGPLHHGVCSTWLNSLKP-QDPV--PCFVRNASGFHLPEDPSHPCILIGPGTGIAPFRSF 992

Query: 469  IQERVAQGQTGNF------LFFGCRWRDQDFYWEAEWQELEKRDCLTLI-PAFSREQPPA 521
             Q+R+   Q          L FGCR  D+D  ++ E  E+ ++  L  +  A+SR     
Sbjct: 993  WQQRLHDSQHKGVRGGRMTLVFGCRRPDEDHIYQEEMLEMAQKGVLHAVHTAYSR----- 1047

Query: 522  LFSALQEQKVYVQHRLR-ELGSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEG 580
                  + KVYVQ  LR +L S V  +L ++  + Y+ G+ + M  DV+  L  +   + 
Sbjct: 1048 ---LPGKPKVYVQDILRQQLASEVLRVLHKEPGHLYVCGDVR-MARDVAHTLKQLVAAKL 1103

Query: 581  GLCSPDAAAYLARLQQTRRFQTE 603
             L       Y  +L+  +R+  +
Sbjct: 1104 KLNEEQVEDYFFQLKSQKRYHED 1126


>gi|169790958 methionine synthase reductase isoform 1 [Homo sapiens]
          Length = 698

 Score =  181 bits (458), Expect = 2e-45
 Identities = 138/480 (28%), Positives = 230/480 (47%), Gaps = 48/480 (10%)

Query: 161 PGLTEIPPGVP-LPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRV 219
           P L++    +P LP ++  + LQE  S G E  +V+        S    F  P+    ++
Sbjct: 233 PPLSQASLNIPGLPPEYLQVHLQE--SLGQEESQVS------VTSADPVFQVPISKAVQL 284

Query: 220 TGPSHFQDVRLIEFDILGSGISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFML--- 276
           T     +   L+E DI  +  S+  GD   +   NS + VQ   Q L L+  +   +   
Sbjct: 285 TTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLK 344

Query: 277 ---QPREPDVSSPTRLPQPCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEF 333
                ++   + P  +P  CS++ + +  L+I ++P+++F   L   +    E+ +L E 
Sbjct: 345 IKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQEL 404

Query: 334 SSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTH 393
            S QG  +   +       +L++L  FP  +   P   LL+ +P ++PR +S ASS L H
Sbjct: 405 CSKQGAADYSRFVRDACACLLDLLLAFP--SCQPPLSLLLEHLPKLQPRPYSCASSSLFH 462

Query: 394 PSRLQILVAVVQFQTRLKEP--RRGLCSSWLASL--------------DPGQGPVRVPLW 437
           P +L  +  +V+F +       R+G+C+ WLA L              D G+  +   + 
Sbjct: 463 PGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKA-LAPKIS 521

Query: 438 VRP---GSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVA---QGQTGNF----LFFGCR 487
           + P    S   P+ P  P+IMVGPGTG+APF   +Q R     Q   GNF    LFFGCR
Sbjct: 522 ISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCR 581

Query: 488 WRDQDFYWEAEWQELEKRDCLT-LIPAFSREQPPALFSALQEQKVYVQHRLRELGSLVWE 546
            +D+D+ +  E +   K   LT L  +FSR+ P     A  +   YVQ  ++  G  V  
Sbjct: 582 HKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGEEEAPAK---YVQDNIQLHGQQVAR 638

Query: 547 LLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTETWA 606
           +L ++  + Y+ G+AK+M  DV +AL+ I  +E G+   +A   LA L++ +R+  + W+
Sbjct: 639 ILLQENGHIYVCGDAKNMAKDVHDALVQIISKEVGVEKLEAMKTLATLKEEKRYLQDIWS 698



 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 51/172 (29%), Positives = 82/172 (47%), Gaps = 5/172 (2%)

Query: 5   QLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINE--PLVIFVCATTG 62
           + L+L+ +Q G A+ ++E +  +A        +  +      +L  E  PLV+ V +TTG
Sbjct: 3   RFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVV-STTG 61

Query: 63  QGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGS 122
            GDPPD  + F + I  + LP      + + +LGLGDS Y  F    K + +RL +LG  
Sbjct: 62  TGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGAR 121

Query: 123 ALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPS 174
                   DD   +G +  V+PW+  LW  +   +    G  EI   +P+ S
Sbjct: 122 HFYDTGHADDC--VGLELVVEPWIAGLWPALRKHFRSSRGQEEISGALPVAS 171


>gi|169790956 methionine synthase reductase isoform 2 [Homo sapiens]
          Length = 725

 Score =  181 bits (458), Expect = 2e-45
 Identities = 138/480 (28%), Positives = 230/480 (47%), Gaps = 48/480 (10%)

Query: 161 PGLTEIPPGVP-LPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRV 219
           P L++    +P LP ++  + LQE  S G E  +V+        S    F  P+    ++
Sbjct: 260 PPLSQASLNIPGLPPEYLQVHLQE--SLGQEESQVS------VTSADPVFQVPISKAVQL 311

Query: 220 TGPSHFQDVRLIEFDILGSGISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFML--- 276
           T     +   L+E DI  +  S+  GD   +   NS + VQ   Q L L+  +   +   
Sbjct: 312 TTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLK 371

Query: 277 ---QPREPDVSSPTRLPQPCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEF 333
                ++   + P  +P  CS++ + +  L+I ++P+++F   L   +    E+ +L E 
Sbjct: 372 IKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQEL 431

Query: 334 SSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTH 393
            S QG  +   +       +L++L  FP  +   P   LL+ +P ++PR +S ASS L H
Sbjct: 432 CSKQGAADYSRFVRDACACLLDLLLAFP--SCQPPLSLLLEHLPKLQPRPYSCASSSLFH 489

Query: 394 PSRLQILVAVVQFQTRLKEP--RRGLCSSWLASL--------------DPGQGPVRVPLW 437
           P +L  +  +V+F +       R+G+C+ WLA L              D G+  +   + 
Sbjct: 490 PGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKA-LAPKIS 548

Query: 438 VRP---GSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVA---QGQTGNF----LFFGCR 487
           + P    S   P+ P  P+IMVGPGTG+APF   +Q R     Q   GNF    LFFGCR
Sbjct: 549 ISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCR 608

Query: 488 WRDQDFYWEAEWQELEKRDCLT-LIPAFSREQPPALFSALQEQKVYVQHRLRELGSLVWE 546
            +D+D+ +  E +   K   LT L  +FSR+ P     A  +   YVQ  ++  G  V  
Sbjct: 609 HKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGEEEAPAK---YVQDNIQLHGQQVAR 665

Query: 547 LLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTETWA 606
           +L ++  + Y+ G+AK+M  DV +AL+ I  +E G+   +A   LA L++ +R+  + W+
Sbjct: 666 ILLQENGHIYVCGDAKNMAKDVHDALVQIISKEVGVEKLEAMKTLATLKEEKRYLQDIWS 725



 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 51/172 (29%), Positives = 82/172 (47%), Gaps = 5/172 (2%)

Query: 5   QLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINE--PLVIFVCATTG 62
           + L+L+ +Q G A+ ++E +  +A        +  +      +L  E  PLV+ V +TTG
Sbjct: 30  RFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVV-STTG 88

Query: 63  QGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGS 122
            GDPPD  + F + I  + LP      + + +LGLGDS Y  F    K + +RL +LG  
Sbjct: 89  TGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGAR 148

Query: 123 ALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPS 174
                   DD   +G +  V+PW+  LW  +   +    G  EI   +P+ S
Sbjct: 149 HFYDTGHADDC--VGLELVVEPWIAGLWPALRKHFRSSRGQEEISGALPVAS 198


>gi|231571329 nitric oxide synthase 3 isoform 3 [Homo sapiens]
          Length = 614

 Score = 59.7 bits (143), Expect = 8e-09
 Identities = 34/82 (41%), Positives = 49/82 (59%), Gaps = 2/82 (2%)

Query: 8   VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67
           +L+GS+TG AQ  +++LGR   R+    RV  +D Y VV+L +E LV+ V +T G GDPP
Sbjct: 522 ILYGSETGRAQSYAQQLGR-LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPP 580

Query: 68  DNMKNFWRFIFRKNLPSTALCQ 89
           +N +  W F     L S +  Q
Sbjct: 581 ENGER-WGFAMLPRLVSNSWVQ 601


>gi|231571356 nitric oxide synthase 3 isoform 4 [Homo sapiens]
          Length = 629

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 29/62 (46%), Positives = 42/62 (67%), Gaps = 1/62 (1%)

Query: 8   VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67
           +L+GS+TG AQ  +++LGR   R+    RV  +D Y VV+L +E LV+ V +T G GDPP
Sbjct: 522 ILYGSETGRAQSYAQQLGR-LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPP 580

Query: 68  DN 69
           +N
Sbjct: 581 EN 582


>gi|231571314 nitric oxide synthase 3 isoform 2 [Homo sapiens]
          Length = 596

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 29/62 (46%), Positives = 42/62 (67%), Gaps = 1/62 (1%)

Query: 8   VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67
           +L+GS+TG AQ  +++LGR   R+    RV  +D Y VV+L +E LV+ V +T G GDPP
Sbjct: 522 ILYGSETGRAQSYAQQLGR-LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPP 580

Query: 68  DN 69
           +N
Sbjct: 581 EN 582


>gi|50726981 radical S-adenosyl methionine and flavodoxin domains 1
           [Homo sapiens]
          Length = 732

 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 41/134 (30%), Positives = 65/134 (48%), Gaps = 10/134 (7%)

Query: 8   VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSY-PVVNLINEP----LVIFVCATTG 62
           + +GSQTGTA+  +  L        L   +  L  Y P  +LI E     + +F+ AT  
Sbjct: 81  IFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYT 140

Query: 63  QGDPPDNMKNFWRFIFRKNLP----STALCQMDFAVLGLGDSSYAK-FNFVAKKLHRRLL 117
            G P ++ + F +++   ++      T L  M +AV GLG+S+YA  FN V K + + L 
Sbjct: 141 DGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLW 200

Query: 118 QLGGSALLPVCLGD 131
            LG   ++    GD
Sbjct: 201 MLGAHRVMSRGEGD 214


>gi|18959210 WIRE protein [Homo sapiens]
          Length = 440

 Score = 38.1 bits (87), Expect = 0.024
 Identities = 27/68 (39%), Positives = 33/68 (48%), Gaps = 4/68 (5%)

Query: 158 PPPPGLTEIPPGVPLP--SKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMIS 215
           PPPPG     P  PLP  S     + +E P   + GQR+ HPG + PP+       P   
Sbjct: 179 PPPPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRL-HPGREGPPAPPPVKPPPSPV 237

Query: 216 NQRVTGPS 223
           N R TGPS
Sbjct: 238 NIR-TGPS 244


>gi|224282123 tRNA-yW synthesizing protein 1 homolog B isoform 1
           [Homo sapiens]
          Length = 668

 Score = 35.0 bits (79), Expect = 0.20
 Identities = 25/85 (29%), Positives = 45/85 (52%), Gaps = 5/85 (5%)

Query: 41  DSYPVVNLINEPLVIFVCATTGQGDPPDNMKNFWRFIFRKNLP----STALCQMDFAVLG 96
           D + +  + ++ + +F+ AT   G P ++ + F +++   ++      T L  M  AV G
Sbjct: 73  DDHLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRDAVFG 132

Query: 97  LGDSSYAK-FNFVAKKLHRRLLQLG 120
           LG+S+YA  FN V K + + L  LG
Sbjct: 133 LGNSAYASHFNKVGKNVDKWLWMLG 157


>gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [Homo
            sapiens]
          Length = 1584

 Score = 35.0 bits (79), Expect = 0.20
 Identities = 21/56 (37%), Positives = 24/56 (42%), Gaps = 2/56 (3%)

Query: 158  PPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPM 213
            PPPP     PP  PLP    L      PS G  G+  AHPG    PS     +A +
Sbjct: 1412 PPPPPPPPPPPQQPLPPPPNLE--PAPPSLGDPGEPAAHPGPSTGPSTKNENVATL 1465


>gi|221139926 NHS-like 1 [Homo sapiens]
          Length = 1606

 Score = 34.3 bits (77), Expect = 0.34
 Identities = 31/92 (33%), Positives = 38/92 (41%), Gaps = 8/92 (8%)

Query: 123  ALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGL--TEIPPGVPLPSKFTLLF 180
            AL+P C   D     P  A+ P L D     + L  PPP L  +E PP  PL  KF    
Sbjct: 978  ALIPFCSPPDWCLSPPRPALSPILPD---SPVSLPLPPPLLPSSEPPPAPPLDPKF---M 1031

Query: 181  LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAP 212
                P   + GQ  +  GS  PPS  +    P
Sbjct: 1032 KDTRPPFTNSGQPESSRGSLRPPSTKEETSRP 1063


>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo
           sapiens]
          Length = 1758

 Score = 34.3 bits (77), Expect = 0.34
 Identities = 22/57 (38%), Positives = 29/57 (50%), Gaps = 4/57 (7%)

Query: 156 LYPPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSE-SKPFLA 211
           LYPPPP    +PPGVP P +F+  F    P     G  V  PG    P+  S P+++
Sbjct: 564 LYPPPPHTLPLPPGVP-PPQFSPQFPPGQPPPA--GYSVPPPGFPPAPANLSTPWVS 617


>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo
           sapiens]
          Length = 1792

 Score = 34.3 bits (77), Expect = 0.34
 Identities = 22/57 (38%), Positives = 29/57 (50%), Gaps = 4/57 (7%)

Query: 156 LYPPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSE-SKPFLA 211
           LYPPPP    +PPGVP P +F+  F    P     G  V  PG    P+  S P+++
Sbjct: 564 LYPPPPHTLPLPPGVP-PPQFSPQFPPGQPPPA--GYSVPPPGFPPAPANLSTPWVS 617


>gi|27312029 hypothetical protein LOC145376 [Homo sapiens]
          Length = 422

 Score = 33.5 bits (75), Expect = 0.58
 Identities = 27/81 (33%), Positives = 38/81 (46%), Gaps = 5/81 (6%)

Query: 1   MPSPQLLVLFGSQTGTAQDVSERLGREARRR---RLGCRVQALDSYP--VVNLINEPLVI 55
           M SP +  L  S    AQ+V E+   +   R    +   V  LDS P  VV ++ EP  +
Sbjct: 312 MRSPVMSTLLPSLREKAQNVFEKKYHQVDVRFPAEMQKHVGTLDSVPMPVVGILGEPRCL 371

Query: 56  FVCATTGQGDPPDNMKNFWRF 76
           F   T    DP +N K+F R+
Sbjct: 372 FNPHTLHPLDPEENTKSFGRY 392


>gi|145587088 hypothetical protein LOC165186 [Homo sapiens]
          Length = 1019

 Score = 32.7 bits (73), Expect = 0.99
 Identities = 18/35 (51%), Positives = 23/35 (65%), Gaps = 2/35 (5%)

Query: 404 VQFQTRLKEPR--RGLCSSWLASLDPGQGPVRVPL 436
           +Q + +LK+ R   GL +S  ASLDPG GP  VPL
Sbjct: 122 IQIKDKLKKRRLSEGLAASSRASLDPGGGPQGVPL 156


>gi|239753314 PREDICTED: similar to RIKEN cDNA C230030N03 [Homo
           sapiens]
          Length = 1183

 Score = 31.2 bits (69), Expect = 2.9
 Identities = 29/126 (23%), Positives = 46/126 (36%), Gaps = 18/126 (14%)

Query: 141 AVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQ 200
           A +P  R  + +V       P  TE P GVP P+     +    P         A  G  
Sbjct: 715 AQEPGKRPTFSKVTSFRKGRPLATESPGGVPAPTTEGRRWGSSGPEGLPRENPPAAAGRD 774

Query: 201 EPP-----SESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGISFAAGDVVLIQPSNS 255
            PP     + + P   P  +  R  GP+             G+G +  +GD+    PS+ 
Sbjct: 775 APPLHHGDASAWPEFVPQAAGDRTAGPA-------------GAGHTGTSGDLGSRGPSSE 821

Query: 256 AAHVQR 261
           + + +R
Sbjct: 822 SCNAKR 827


>gi|151301053 RNA binding motif protein 33 [Homo sapiens]
          Length = 1170

 Score = 31.2 bits (69), Expect = 2.9
 Identities = 14/40 (35%), Positives = 21/40 (52%)

Query: 158 PPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHP 197
           PPPP  T +    P+P++  L F Q  P+   +GQ+   P
Sbjct: 484 PPPPPPTLLNSSHPVPTQSPLPFTQPGPAFNQQGQQPVFP 523


>gi|68161504 Wiskott-Aldrich syndrome protein family member 1 [Homo
           sapiens]
          Length = 559

 Score = 30.8 bits (68), Expect = 3.8
 Identities = 21/65 (32%), Positives = 25/65 (38%), Gaps = 7/65 (10%)

Query: 153 VLGLYPPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAP 212
           V GL PPPP     PPG+   S  T+  L   PS         HP     P    P + P
Sbjct: 420 VQGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSG-------LHPTPSTAPGPHVPLMPP 472

Query: 213 MISNQ 217
              +Q
Sbjct: 473 SPPSQ 477


>gi|68161502 Wiskott-Aldrich syndrome protein family member 1 [Homo
           sapiens]
          Length = 559

 Score = 30.8 bits (68), Expect = 3.8
 Identities = 21/65 (32%), Positives = 25/65 (38%), Gaps = 7/65 (10%)

Query: 153 VLGLYPPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAP 212
           V GL PPPP     PPG+   S  T+  L   PS         HP     P    P + P
Sbjct: 420 VQGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSG-------LHPTPSTAPGPHVPLMPP 472

Query: 213 MISNQ 217
              +Q
Sbjct: 473 SPPSQ 477


>gi|68161500 Wiskott-Aldrich syndrome protein family member 1 [Homo
           sapiens]
          Length = 559

 Score = 30.8 bits (68), Expect = 3.8
 Identities = 21/65 (32%), Positives = 25/65 (38%), Gaps = 7/65 (10%)

Query: 153 VLGLYPPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAP 212
           V GL PPPP     PPG+   S  T+  L   PS         HP     P    P + P
Sbjct: 420 VQGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSG-------LHPTPSTAPGPHVPLMPP 472

Query: 213 MISNQ 217
              +Q
Sbjct: 473 SPPSQ 477


>gi|4507913 Wiskott-Aldrich syndrome protein family member 1 [Homo
           sapiens]
          Length = 559

 Score = 30.8 bits (68), Expect = 3.8
 Identities = 21/65 (32%), Positives = 25/65 (38%), Gaps = 7/65 (10%)

Query: 153 VLGLYPPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAP 212
           V GL PPPP     PPG+   S  T+  L   PS         HP     P    P + P
Sbjct: 420 VQGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSG-------LHPTPSTAPGPHVPLMPP 472

Query: 213 MISNQ 217
              +Q
Sbjct: 473 SPPSQ 477


>gi|239757699 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 270

 Score = 30.8 bits (68), Expect = 3.8
 Identities = 26/89 (29%), Positives = 36/89 (40%), Gaps = 3/89 (3%)

Query: 126 PVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLFLQEAP 185
           P+CL   Q    P ++   W   L DR+LG      G  E PP     S+          
Sbjct: 79  PICLPHPQGPRPPSSS-PRWPWGLGDRLLGARASRSGPQEPPPPGSTVSRRKAG--NRPR 135

Query: 186 STGSEGQRVAHPGSQEPPSESKPFLAPMI 214
             G+ G +   PG+ E PS   P L P++
Sbjct: 136 LRGTAGGKAQGPGNPEGPSSLLPRLLPLL 164


>gi|239756047 PREDICTED: heparan sulfate 6-O-sulfotransferase 3
           [Homo sapiens]
          Length = 471

 Score = 30.8 bits (68), Expect = 3.8
 Identities = 31/114 (27%), Positives = 45/114 (39%), Gaps = 19/114 (16%)

Query: 135 ELGPDAAVDPWLR-----DLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLFLQEA--PST 187
           E GP A   P  R     + W+R   L PPP G  E P G   P +      +E   P  
Sbjct: 45  EAGPPAVPGPARRAQAPPEEWERRPQLPPPPRGPPEGPRGAAAPEEED----EEPGDPRE 100

Query: 188 GSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDV-RLIEFDILGSGI 240
           G E +    P  + P + S P   P  +          +D+ R ++F+I G  +
Sbjct: 101 GEEEEEEDEPDPEAPENGSLPRFVPRFN-------FSLKDLTRFVDFNIKGRDV 147


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.139    0.433 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,622,686
Number of Sequences: 37866
Number of extensions: 1450529
Number of successful extensions: 4361
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 42
Number of HSP's that attempted gapping in prelim test: 4248
Number of HSP's gapped (non-prelim): 91
length of query: 606
length of database: 18,247,518
effective HSP length: 108
effective length of query: 498
effective length of database: 14,157,990
effective search space: 7050679020
effective search space used: 7050679020
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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