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Search of human proteins with 221316705
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|221316705 NADPH dependent diflavin oxidoreductase 1 isoform
a [Homo sapiens]
(606 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|221316705 NADPH dependent diflavin oxidoreductase 1 isoform a... 1234 0.0
gi|7657393 NADPH dependent diflavin oxidoreductase 1 isoform b [... 1209 0.0
gi|221316709 NADPH dependent diflavin oxidoreductase 1 isoform c... 1187 0.0
gi|221316707 NADPH dependent diflavin oxidoreductase 1 isoform d... 1006 0.0
gi|127139033 cytochrome P450 reductase [Homo sapiens] 284 1e-76
gi|40254422 nitric oxide synthase 3 isoform 1 [Homo sapiens] 194 2e-49
gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens] 188 1e-47
gi|24041029 nitric oxide synthase 2A [Homo sapiens] 187 3e-47
gi|169790958 methionine synthase reductase isoform 1 [Homo sapiens] 181 2e-45
gi|169790956 methionine synthase reductase isoform 2 [Homo sapiens] 181 2e-45
gi|231571329 nitric oxide synthase 3 isoform 3 [Homo sapiens] 60 8e-09
gi|231571356 nitric oxide synthase 3 isoform 4 [Homo sapiens] 57 4e-08
gi|231571314 nitric oxide synthase 3 isoform 2 [Homo sapiens] 57 4e-08
gi|50726981 radical S-adenosyl methionine and flavodoxin domains... 47 5e-05
gi|18959210 WIRE protein [Homo sapiens] 38 0.024
gi|224282123 tRNA-yW synthesizing protein 1 homolog B isoform 1 ... 35 0.20
gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [... 35 0.20
gi|221139926 NHS-like 1 [Homo sapiens] 34 0.34
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap... 34 0.34
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap... 34 0.34
gi|27312029 hypothetical protein LOC145376 [Homo sapiens] 33 0.58
gi|145587088 hypothetical protein LOC165186 [Homo sapiens] 33 0.99
gi|239753314 PREDICTED: similar to RIKEN cDNA C230030N03 [Homo s... 31 2.9
gi|151301053 RNA binding motif protein 33 [Homo sapiens] 31 2.9
gi|68161504 Wiskott-Aldrich syndrome protein family member 1 [Ho... 31 3.8
gi|68161502 Wiskott-Aldrich syndrome protein family member 1 [Ho... 31 3.8
gi|68161500 Wiskott-Aldrich syndrome protein family member 1 [Ho... 31 3.8
gi|4507913 Wiskott-Aldrich syndrome protein family member 1 [Hom... 31 3.8
gi|239757699 PREDICTED: hypothetical protein [Homo sapiens] 31 3.8
gi|239756047 PREDICTED: heparan sulfate 6-O-sulfotransferase 3 [... 31 3.8
>gi|221316705 NADPH dependent diflavin oxidoreductase 1 isoform a
[Homo sapiens]
Length = 606
Score = 1234 bits (3192), Expect = 0.0
Identities = 606/606 (100%), Positives = 606/606 (100%)
Query: 1 MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 60
MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT
Sbjct: 1 MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 60
Query: 61 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120
TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG
Sbjct: 61 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120
Query: 121 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 180
GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF
Sbjct: 121 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 180
Query: 181 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 240
LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI
Sbjct: 181 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 240
Query: 241 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 300
SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS
Sbjct: 241 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 300
Query: 301 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 360
HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF
Sbjct: 301 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 360
Query: 361 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 420
PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS
Sbjct: 361 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 420
Query: 421 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 480
WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN
Sbjct: 421 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 480
Query: 481 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQPPALFSALQEQKVYVQHRLREL 540
FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQPPALFSALQEQKVYVQHRLREL
Sbjct: 481 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQPPALFSALQEQKVYVQHRLREL 540
Query: 541 GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF 600
GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF
Sbjct: 541 GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF 600
Query: 601 QTETWA 606
QTETWA
Sbjct: 601 QTETWA 606
>gi|7657393 NADPH dependent diflavin oxidoreductase 1 isoform b
[Homo sapiens]
Length = 597
Score = 1209 bits (3127), Expect = 0.0
Identities = 597/606 (98%), Positives = 597/606 (98%), Gaps = 9/606 (1%)
Query: 1 MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 60
MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT
Sbjct: 1 MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 60
Query: 61 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120
TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG
Sbjct: 61 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120
Query: 121 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 180
GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF
Sbjct: 121 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 180
Query: 181 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 240
LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI
Sbjct: 181 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 240
Query: 241 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 300
SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS
Sbjct: 241 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 300
Query: 301 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 360
HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF
Sbjct: 301 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 360
Query: 361 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 420
PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS
Sbjct: 361 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 420
Query: 421 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 480
WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN
Sbjct: 421 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 480
Query: 481 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQPPALFSALQEQKVYVQHRLREL 540
FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSRE QEQKVYVQHRLREL
Sbjct: 481 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSRE---------QEQKVYVQHRLREL 531
Query: 541 GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF 600
GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF
Sbjct: 532 GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF 591
Query: 601 QTETWA 606
QTETWA
Sbjct: 592 QTETWA 597
>gi|221316709 NADPH dependent diflavin oxidoreductase 1 isoform c
[Homo sapiens]
Length = 590
Score = 1187 bits (3071), Expect = 0.0
Identities = 590/606 (97%), Positives = 590/606 (97%), Gaps = 16/606 (2%)
Query: 1 MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 60
MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT
Sbjct: 1 MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 60
Query: 61 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120
TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG
Sbjct: 61 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120
Query: 121 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 180
GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF
Sbjct: 121 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 180
Query: 181 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 240
LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI
Sbjct: 181 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 240
Query: 241 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 300
SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS
Sbjct: 241 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 300
Query: 301 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 360
HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF
Sbjct: 301 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 360
Query: 361 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 420
PHTAAAIPPDYLLDLIPVIRPRAFSIASSLL ILVAVVQFQTRLKEPRRGLCSS
Sbjct: 361 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLL-------ILVAVVQFQTRLKEPRRGLCSS 413
Query: 421 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 480
WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN
Sbjct: 414 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 473
Query: 481 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQPPALFSALQEQKVYVQHRLREL 540
FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSRE QEQKVYVQHRLREL
Sbjct: 474 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSRE---------QEQKVYVQHRLREL 524
Query: 541 GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF 600
GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF
Sbjct: 525 GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF 584
Query: 601 QTETWA 606
QTETWA
Sbjct: 585 QTETWA 590
>gi|221316707 NADPH dependent diflavin oxidoreductase 1 isoform d
[Homo sapiens]
Length = 521
Score = 1006 bits (2600), Expect = 0.0
Identities = 508/551 (92%), Positives = 508/551 (92%), Gaps = 43/551 (7%)
Query: 1 MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 60
MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT
Sbjct: 1 MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 60
Query: 61 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120
TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG
Sbjct: 61 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120
Query: 121 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 180
GSALLPVCLGDDQHELG LPSKFTLLF
Sbjct: 121 GSALLPVCLGDDQHELG----------------------------------LPSKFTLLF 146
Query: 181 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 240
LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI
Sbjct: 147 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 206
Query: 241 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 300
SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS
Sbjct: 207 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 266
Query: 301 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 360
HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF
Sbjct: 267 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 326
Query: 361 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 420
PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS
Sbjct: 327 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 386
Query: 421 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 480
WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN
Sbjct: 387 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 446
Query: 481 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQPPALFSALQEQKVYVQHRLREL 540
FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSRE QEQKVYVQHRLREL
Sbjct: 447 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSRE---------QEQKVYVQHRLREL 497
Query: 541 GSLVWELLDRQ 551
GSLVWELLDRQ
Sbjct: 498 GSLVWELLDRQ 508
>gi|127139033 cytochrome P450 reductase [Homo sapiens]
Length = 680
Score = 284 bits (727), Expect = 1e-76
Identities = 197/618 (31%), Positives = 313/618 (50%), Gaps = 37/618 (5%)
Query: 6 LLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNL-----INEPLVIFVCAT 60
++V +GSQTGTA++ + RL ++A R + + Y + +L I+ LV+F AT
Sbjct: 83 IIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMAT 142
Query: 61 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 120
G+GDP DN ++F+ ++ ++ L + FAV GLG+ +Y FN + K + +RL QLG
Sbjct: 143 YGEGDPTDNAQDFYDWLQETDVD---LSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLG 199
Query: 121 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 180
+ + LGDD L D W W V + T +
Sbjct: 200 AQRIFELGLGDDDGNLEEDFIT--WREQFWPAVCEHFGVEA--TGEESSIRQYELVVHTD 255
Query: 181 LQEAPSTGSEGQRVAHPGSQEPPSESK-PFLAPMISNQRVTGPSHFQDVRLIEFDILGSG 239
+ A E R+ +Q+PP ++K PFLA + +N+++ + + + +E DI S
Sbjct: 256 IDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTE-RHLMHLELDISDSK 314
Query: 240 ISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLV 299
I + +GD V + P+N +A V + ++LG D D + L + + + P P S R +
Sbjct: 315 IRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHPFPCPTSYRTAL 374
Query: 300 SHYLDIASVPRRSFFELLACLSLHELEREKL--LEFSSAQGQEELFEYCNRPRRTILEVL 357
++YLDI + PR + LA + E+E L + SS +G+E + RR IL +L
Sbjct: 375 TYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAIL 434
Query: 358 CDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGL 417
D P + P D+L +L+P ++ R +SIASS HP+ + I VV+++T+ +G+
Sbjct: 435 QDCP--SLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGV 492
Query: 418 CSSWLASLDP---GQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVA 474
++WL + +P G VP++VR P TPVIMVGPGTGVAPF IQER
Sbjct: 493 ATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAW 552
Query: 475 QGQTG-----NFLFFGCRWRDQDFYWEAEWQELEKRDCLT-LIPAFSREQPPALFSALQE 528
Q G L++GCR D+D+ + E + + LT L AFSRE Q
Sbjct: 553 LRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSRE---------QS 603
Query: 529 QKVYVQHRLRELGSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAA 588
KVYVQH L++ +W+L++ GA+ Y+ G+A++M DV I E G + A
Sbjct: 604 HKVYVQHLLKQDREHLWKLIE-GGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAV 662
Query: 589 AYLARLQQTRRFQTETWA 606
Y+ +L R+ + W+
Sbjct: 663 DYIKKLMTKGRYSLDVWS 680
>gi|40254422 nitric oxide synthase 3 isoform 1 [Homo sapiens]
Length = 1203
Score = 194 bits (493), Expect = 2e-49
Identities = 187/663 (28%), Positives = 299/663 (45%), Gaps = 93/663 (14%)
Query: 8 VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67
+L+GS+TG AQ +++LGR R+ RV +D Y VV+L +E LV+ V +T G GDPP
Sbjct: 522 ILYGSETGRAQSYAQQLGR-LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPP 580
Query: 68 DNMKNF---------------------------------------WRFIFRKNLPST--- 85
+N ++F WR RK S+
Sbjct: 581 ENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSISCSDPLVSSWR---RKRKESSNTD 637
Query: 86 ---ALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGPDAAV 142
AL + F V GLG +Y F A+ + RL +LGG LL + GD+ G + A
Sbjct: 638 SAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDEL--CGQEEAF 695
Query: 143 DPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEP 202
W + + + + P + + + S +EG ++ PG
Sbjct: 696 RGWAQAAFQAACETFCVGEDAKAAARDIFSPKR-SWKRQRYRLSAQAEGLQLL-PGLIHV 753
Query: 203 PSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGS-GISFAAGDVVLIQPSNSAAHVQR 261
K F A + S + + + L+ D G G+ + GD + + P N V+
Sbjct: 754 -HRRKMFQATIRSVENLQSSKSTRATILVRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEA 812
Query: 262 FCQVLG-----LDPDQLFMLQPREPDVSSP-----TRLPQPCSMRHLVSHYLDIASVPRR 311
+ +P + L+ P P RLP PC++R ++ +LDI S P
Sbjct: 813 LLSRVEDPPAPTEPVAVEQLEKGSPGGPPPGWVRDPRLP-PCTLRQALTFFLDITSPPSP 871
Query: 312 SFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPDY 371
LL+ L+ E+++L S + E +++ P T+LEVL FP + A+P
Sbjct: 872 QLLRLLSTLAEEPREQQELEALSQDPRRYEEWKWFRCP--TLLEVLEQFP--SVALPAPL 927
Query: 372 LLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTR--LKEPRRGLCSSWLASLDPGQ 429
LL +P+++PR +S++S+ THP + + VAV+ ++T+ L G+CS+WL+ L PG
Sbjct: 928 LLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAVLAYRTQDGLGPLHYGVCSTWLSQLKPGD 987
Query: 430 GPVRVPLWVRPG-SLAFPETPDTPVIMVGPGTGVAPFRAAIQERV----AQG--QTGNFL 482
VP ++R S P P P I+VGPGTG+APFR QER+ ++G T L
Sbjct: 988 P---VPCFIRGAPSFRLPPDPSLPCILVGPGTGIAPFRGFWQERLHDIESKGLQPTPMTL 1044
Query: 483 FFGCRWRDQDFYWEAEWQELEKRDCL-TLIPAFSREQPPALFSALQEQKVYVQHRLR-EL 540
FGCR D + E Q ++R ++ AFSRE K YVQ LR EL
Sbjct: 1045 VFGCRCSQLDHLYRDEVQNAQQRGVFGRVLTAFSREP--------DNPKTYVQDILRTEL 1096
Query: 541 GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF 600
+ V +L + + ++ G+ +M +V + + I EG + +A + L+ +R+
Sbjct: 1097 AAEVHRVLCLERGHMFVCGDV-TMATNVLQTVQRILATEGDMELDEAGDVIGVLRDQQRY 1155
Query: 601 QTE 603
+
Sbjct: 1156 HED 1158
>gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]
Length = 1434
Score = 188 bits (477), Expect = 1e-47
Identities = 178/666 (26%), Positives = 292/666 (43%), Gaps = 99/666 (14%)
Query: 8 VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67
+L+ ++TG +Q ++ L E + +V +++ Y +V+L +E LV+ V +T G GDPP
Sbjct: 762 ILYATETGKSQAYAKTLC-EIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPP 820
Query: 68 DNMKNFWRFIFRKNLPSTA---------------------------------------LC 88
+N + F + P++ L
Sbjct: 821 ENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLA 880
Query: 89 QMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGPDAAVDPWLRD 148
+ F+V GLG +Y F + L +LGG +L + GD+ G + A W +
Sbjct: 881 NVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDEL--CGQEEAFRTWAKK 938
Query: 149 LWDRVLGLYPPPPGLTEIPPGVPLPS--------KFTLLFLQEAPSTGSEGQRVAHPGSQ 200
++ ++ + L S KF L F+ EAP ++G H
Sbjct: 939 VFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPEL-TQGLSNVH---- 993
Query: 201 EPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSG-ISFAAGDVVLIQPSNSAAHV 259
+ + A ++S Q + P + + GS + + GD + + P N V
Sbjct: 994 ----KKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLV 1049
Query: 260 QRFCQVLGLDPD-----QLFMLQPREPDV------SSPTRLPQPCSMRHLVSHYLDIASV 308
+ L P ++ +L+ R + + RLP PC++ +YLDI +
Sbjct: 1050 NALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLP-PCTIFQAFKYYLDITTP 1108
Query: 309 PRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIP 368
P + A L+ E E+++LL S + E +++ P TI+EVL +FP + +P
Sbjct: 1109 PTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNP--TIVEVLEEFP--SIQMP 1164
Query: 369 PDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEP--RRGLCSSWLASLD 426
LL + +++PR +SI+SS +P + + VA+V ++TR E G+CSSWL +
Sbjct: 1165 ATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRI- 1223
Query: 427 PGQGPVRVPLWVRPG-SLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGNF---- 481
Q VP +VR S P P P I+VGPGTG+APFR+ Q+R Q
Sbjct: 1224 --QADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCP 1281
Query: 482 --LFFGCRWRDQD-FYWEAEWQELEKRDCLTLIPAFSREQPPALFSALQEQKVYVQHRLR 538
L FGCR D Y E Q K L A+SRE + K YVQ L+
Sbjct: 1282 MVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREP--------DKPKKYVQDILQ 1333
Query: 539 E-LGSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQT 597
E L V+ L QG + Y+ G+ +M ADV +A+ I ++G L + DA +++R++
Sbjct: 1334 EQLAESVYRALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSAEDAGVFISRMRDD 1392
Query: 598 RRFQTE 603
R+ +
Sbjct: 1393 NRYHED 1398
>gi|24041029 nitric oxide synthase 2A [Homo sapiens]
Length = 1153
Score = 187 bits (474), Expect = 3e-47
Identities = 175/623 (28%), Positives = 292/623 (46%), Gaps = 58/623 (9%)
Query: 5 QLLVLFGSQTGTAQDVSERLGREARRRRLGC----RVQALDSYPVVNLINEPLVIFVCAT 60
++ +LF ++TG ++ ++ LG C +V +D Y + L E L++ V +T
Sbjct: 538 RVTILFATETGKSEALAWDLGA-----LFSCAFNPKVVCMDKYRLSCLEEERLLLVVTST 592
Query: 61 TGQGDPPDNMKNFWRFIFR-KNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQL 119
G GD P N + + +F K L + + +AV GLG S Y +F A + ++L L
Sbjct: 593 FGNGDCPGNGEKLKKSLFMLKELNN----KFRYAVFGLGSSMYPRFCAFAHDIDQKLSHL 648
Query: 120 GGSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFT-- 177
G S L P+ GD+ G + A W + + + +P +T
Sbjct: 649 GASQLTPMGEGDELS--GQEDAFRSWAVQTFKAACETFD-----VRGKQHIQIPKLYTSN 701
Query: 178 LLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDIL- 236
+ + + Q + + F + S Q + P+ + L+E
Sbjct: 702 VTWDPHHYRLVQDSQPLDLSKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCED 761
Query: 237 GSGISFAAGDVVLIQPSNSAAHVQRFCQ--VLGLDPDQLFMLQPREPDVS---SPTRLPQ 291
G G+++ G+ + + P N A VQ + V G P Q L+ + S S RLP
Sbjct: 762 GQGLNYLPGEHLGVCPGNQPALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLP- 820
Query: 292 PCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRR 351
PCS+ ++++LDI + P + + LA ++ E ER++L E + +++ N P
Sbjct: 821 PCSLSQALTYFLDITTPPTQLLLQKLAQVATEEPERQRL-EALCQPSEYSKWKFTNSP-- 877
Query: 352 TILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLK 411
T LEVL +FP + + +LL +P+++PR +SI+SS P+ + + VAVV + TR
Sbjct: 878 TFLEVLEEFP--SLRVSAGFLLSQLPILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDG 935
Query: 412 EP--RRGLCSSWLASLDPGQGPVRVPLWVRPGS-LAFPETPDTPVIMVGPGTGVAPFRAA 468
+ G+CS+WL SL P Q PV P +VR S PE P P I++GPGTG+APFR+
Sbjct: 936 QGPLHHGVCSTWLNSLKP-QDPV--PCFVRNASGFHLPEDPSHPCILIGPGTGIAPFRSF 992
Query: 469 IQERVAQGQTGNF------LFFGCRWRDQDFYWEAEWQELEKRDCLTLI-PAFSREQPPA 521
Q+R+ Q L FGCR D+D ++ E E+ ++ L + A+SR
Sbjct: 993 WQQRLHDSQHKGVRGGRMTLVFGCRRPDEDHIYQEEMLEMAQKGVLHAVHTAYSR----- 1047
Query: 522 LFSALQEQKVYVQHRLR-ELGSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEG 580
+ KVYVQ LR +L S V +L ++ + Y+ G+ + M DV+ L + +
Sbjct: 1048 ---LPGKPKVYVQDILRQQLASEVLRVLHKEPGHLYVCGDVR-MARDVAHTLKQLVAAKL 1103
Query: 581 GLCSPDAAAYLARLQQTRRFQTE 603
L Y +L+ +R+ +
Sbjct: 1104 KLNEEQVEDYFFQLKSQKRYHED 1126
>gi|169790958 methionine synthase reductase isoform 1 [Homo sapiens]
Length = 698
Score = 181 bits (458), Expect = 2e-45
Identities = 138/480 (28%), Positives = 230/480 (47%), Gaps = 48/480 (10%)
Query: 161 PGLTEIPPGVP-LPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRV 219
P L++ +P LP ++ + LQE S G E +V+ S F P+ ++
Sbjct: 233 PPLSQASLNIPGLPPEYLQVHLQE--SLGQEESQVS------VTSADPVFQVPISKAVQL 284
Query: 220 TGPSHFQDVRLIEFDILGSGISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFML--- 276
T + L+E DI + S+ GD + NS + VQ Q L L+ + +
Sbjct: 285 TTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLK 344
Query: 277 ---QPREPDVSSPTRLPQPCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEF 333
++ + P +P CS++ + + L+I ++P+++F L + E+ +L E
Sbjct: 345 IKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQEL 404
Query: 334 SSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTH 393
S QG + + +L++L FP + P LL+ +P ++PR +S ASS L H
Sbjct: 405 CSKQGAADYSRFVRDACACLLDLLLAFP--SCQPPLSLLLEHLPKLQPRPYSCASSSLFH 462
Query: 394 PSRLQILVAVVQFQTRLKEP--RRGLCSSWLASL--------------DPGQGPVRVPLW 437
P +L + +V+F + R+G+C+ WLA L D G+ + +
Sbjct: 463 PGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKA-LAPKIS 521
Query: 438 VRP---GSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVA---QGQTGNF----LFFGCR 487
+ P S P+ P P+IMVGPGTG+APF +Q R Q GNF LFFGCR
Sbjct: 522 ISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCR 581
Query: 488 WRDQDFYWEAEWQELEKRDCLT-LIPAFSREQPPALFSALQEQKVYVQHRLRELGSLVWE 546
+D+D+ + E + K LT L +FSR+ P A + YVQ ++ G V
Sbjct: 582 HKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGEEEAPAK---YVQDNIQLHGQQVAR 638
Query: 547 LLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTETWA 606
+L ++ + Y+ G+AK+M DV +AL+ I +E G+ +A LA L++ +R+ + W+
Sbjct: 639 ILLQENGHIYVCGDAKNMAKDVHDALVQIISKEVGVEKLEAMKTLATLKEEKRYLQDIWS 698
Score = 77.0 bits (188), Expect = 5e-14
Identities = 51/172 (29%), Positives = 82/172 (47%), Gaps = 5/172 (2%)
Query: 5 QLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINE--PLVIFVCATTG 62
+ L+L+ +Q G A+ ++E + +A + + +L E PLV+ V +TTG
Sbjct: 3 RFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVV-STTG 61
Query: 63 QGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGS 122
GDPPD + F + I + LP + + +LGLGDS Y F K + +RL +LG
Sbjct: 62 TGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGAR 121
Query: 123 ALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPS 174
DD +G + V+PW+ LW + + G EI +P+ S
Sbjct: 122 HFYDTGHADDC--VGLELVVEPWIAGLWPALRKHFRSSRGQEEISGALPVAS 171
>gi|169790956 methionine synthase reductase isoform 2 [Homo sapiens]
Length = 725
Score = 181 bits (458), Expect = 2e-45
Identities = 138/480 (28%), Positives = 230/480 (47%), Gaps = 48/480 (10%)
Query: 161 PGLTEIPPGVP-LPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRV 219
P L++ +P LP ++ + LQE S G E +V+ S F P+ ++
Sbjct: 260 PPLSQASLNIPGLPPEYLQVHLQE--SLGQEESQVS------VTSADPVFQVPISKAVQL 311
Query: 220 TGPSHFQDVRLIEFDILGSGISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFML--- 276
T + L+E DI + S+ GD + NS + VQ Q L L+ + +
Sbjct: 312 TTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLK 371
Query: 277 ---QPREPDVSSPTRLPQPCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEF 333
++ + P +P CS++ + + L+I ++P+++F L + E+ +L E
Sbjct: 372 IKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQEL 431
Query: 334 SSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTH 393
S QG + + +L++L FP + P LL+ +P ++PR +S ASS L H
Sbjct: 432 CSKQGAADYSRFVRDACACLLDLLLAFP--SCQPPLSLLLEHLPKLQPRPYSCASSSLFH 489
Query: 394 PSRLQILVAVVQFQTRLKEP--RRGLCSSWLASL--------------DPGQGPVRVPLW 437
P +L + +V+F + R+G+C+ WLA L D G+ + +
Sbjct: 490 PGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKA-LAPKIS 548
Query: 438 VRP---GSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVA---QGQTGNF----LFFGCR 487
+ P S P+ P P+IMVGPGTG+APF +Q R Q GNF LFFGCR
Sbjct: 549 ISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCR 608
Query: 488 WRDQDFYWEAEWQELEKRDCLT-LIPAFSREQPPALFSALQEQKVYVQHRLRELGSLVWE 546
+D+D+ + E + K LT L +FSR+ P A + YVQ ++ G V
Sbjct: 609 HKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGEEEAPAK---YVQDNIQLHGQQVAR 665
Query: 547 LLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTETWA 606
+L ++ + Y+ G+AK+M DV +AL+ I +E G+ +A LA L++ +R+ + W+
Sbjct: 666 ILLQENGHIYVCGDAKNMAKDVHDALVQIISKEVGVEKLEAMKTLATLKEEKRYLQDIWS 725
Score = 77.0 bits (188), Expect = 5e-14
Identities = 51/172 (29%), Positives = 82/172 (47%), Gaps = 5/172 (2%)
Query: 5 QLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINE--PLVIFVCATTG 62
+ L+L+ +Q G A+ ++E + +A + + +L E PLV+ V +TTG
Sbjct: 30 RFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVV-STTG 88
Query: 63 QGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGS 122
GDPPD + F + I + LP + + +LGLGDS Y F K + +RL +LG
Sbjct: 89 TGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGAR 148
Query: 123 ALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPS 174
DD +G + V+PW+ LW + + G EI +P+ S
Sbjct: 149 HFYDTGHADDC--VGLELVVEPWIAGLWPALRKHFRSSRGQEEISGALPVAS 198
>gi|231571329 nitric oxide synthase 3 isoform 3 [Homo sapiens]
Length = 614
Score = 59.7 bits (143), Expect = 8e-09
Identities = 34/82 (41%), Positives = 49/82 (59%), Gaps = 2/82 (2%)
Query: 8 VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67
+L+GS+TG AQ +++LGR R+ RV +D Y VV+L +E LV+ V +T G GDPP
Sbjct: 522 ILYGSETGRAQSYAQQLGR-LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPP 580
Query: 68 DNMKNFWRFIFRKNLPSTALCQ 89
+N + W F L S + Q
Sbjct: 581 ENGER-WGFAMLPRLVSNSWVQ 601
>gi|231571356 nitric oxide synthase 3 isoform 4 [Homo sapiens]
Length = 629
Score = 57.4 bits (137), Expect = 4e-08
Identities = 29/62 (46%), Positives = 42/62 (67%), Gaps = 1/62 (1%)
Query: 8 VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67
+L+GS+TG AQ +++LGR R+ RV +D Y VV+L +E LV+ V +T G GDPP
Sbjct: 522 ILYGSETGRAQSYAQQLGR-LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPP 580
Query: 68 DN 69
+N
Sbjct: 581 EN 582
>gi|231571314 nitric oxide synthase 3 isoform 2 [Homo sapiens]
Length = 596
Score = 57.4 bits (137), Expect = 4e-08
Identities = 29/62 (46%), Positives = 42/62 (67%), Gaps = 1/62 (1%)
Query: 8 VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67
+L+GS+TG AQ +++LGR R+ RV +D Y VV+L +E LV+ V +T G GDPP
Sbjct: 522 ILYGSETGRAQSYAQQLGR-LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPP 580
Query: 68 DN 69
+N
Sbjct: 581 EN 582
>gi|50726981 radical S-adenosyl methionine and flavodoxin domains 1
[Homo sapiens]
Length = 732
Score = 47.0 bits (110), Expect = 5e-05
Identities = 41/134 (30%), Positives = 65/134 (48%), Gaps = 10/134 (7%)
Query: 8 VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSY-PVVNLINEP----LVIFVCATTG 62
+ +GSQTGTA+ + L L + L Y P +LI E + +F+ AT
Sbjct: 81 IFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYT 140
Query: 63 QGDPPDNMKNFWRFIFRKNLP----STALCQMDFAVLGLGDSSYAK-FNFVAKKLHRRLL 117
G P ++ + F +++ ++ T L M +AV GLG+S+YA FN V K + + L
Sbjct: 141 DGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLW 200
Query: 118 QLGGSALLPVCLGD 131
LG ++ GD
Sbjct: 201 MLGAHRVMSRGEGD 214
>gi|18959210 WIRE protein [Homo sapiens]
Length = 440
Score = 38.1 bits (87), Expect = 0.024
Identities = 27/68 (39%), Positives = 33/68 (48%), Gaps = 4/68 (5%)
Query: 158 PPPPGLTEIPPGVPLP--SKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMIS 215
PPPPG P PLP S + +E P + GQR+ HPG + PP+ P
Sbjct: 179 PPPPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRL-HPGREGPPAPPPVKPPPSPV 237
Query: 216 NQRVTGPS 223
N R TGPS
Sbjct: 238 NIR-TGPS 244
>gi|224282123 tRNA-yW synthesizing protein 1 homolog B isoform 1
[Homo sapiens]
Length = 668
Score = 35.0 bits (79), Expect = 0.20
Identities = 25/85 (29%), Positives = 45/85 (52%), Gaps = 5/85 (5%)
Query: 41 DSYPVVNLINEPLVIFVCATTGQGDPPDNMKNFWRFIFRKNLP----STALCQMDFAVLG 96
D + + + ++ + +F+ AT G P ++ + F +++ ++ T L M AV G
Sbjct: 73 DDHLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRDAVFG 132
Query: 97 LGDSSYAK-FNFVAKKLHRRLLQLG 120
LG+S+YA FN V K + + L LG
Sbjct: 133 LGNSAYASHFNKVGKNVDKWLWMLG 157
>gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [Homo
sapiens]
Length = 1584
Score = 35.0 bits (79), Expect = 0.20
Identities = 21/56 (37%), Positives = 24/56 (42%), Gaps = 2/56 (3%)
Query: 158 PPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPM 213
PPPP PP PLP L PS G G+ AHPG PS +A +
Sbjct: 1412 PPPPPPPPPPPQQPLPPPPNLE--PAPPSLGDPGEPAAHPGPSTGPSTKNENVATL 1465
>gi|221139926 NHS-like 1 [Homo sapiens]
Length = 1606
Score = 34.3 bits (77), Expect = 0.34
Identities = 31/92 (33%), Positives = 38/92 (41%), Gaps = 8/92 (8%)
Query: 123 ALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGL--TEIPPGVPLPSKFTLLF 180
AL+P C D P A+ P L D + L PPP L +E PP PL KF
Sbjct: 978 ALIPFCSPPDWCLSPPRPALSPILPD---SPVSLPLPPPLLPSSEPPPAPPLDPKF---M 1031
Query: 181 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAP 212
P + GQ + GS PPS + P
Sbjct: 1032 KDTRPPFTNSGQPESSRGSLRPPSTKEETSRP 1063
>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo
sapiens]
Length = 1758
Score = 34.3 bits (77), Expect = 0.34
Identities = 22/57 (38%), Positives = 29/57 (50%), Gaps = 4/57 (7%)
Query: 156 LYPPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSE-SKPFLA 211
LYPPPP +PPGVP P +F+ F P G V PG P+ S P+++
Sbjct: 564 LYPPPPHTLPLPPGVP-PPQFSPQFPPGQPPPA--GYSVPPPGFPPAPANLSTPWVS 617
>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo
sapiens]
Length = 1792
Score = 34.3 bits (77), Expect = 0.34
Identities = 22/57 (38%), Positives = 29/57 (50%), Gaps = 4/57 (7%)
Query: 156 LYPPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSE-SKPFLA 211
LYPPPP +PPGVP P +F+ F P G V PG P+ S P+++
Sbjct: 564 LYPPPPHTLPLPPGVP-PPQFSPQFPPGQPPPA--GYSVPPPGFPPAPANLSTPWVS 617
>gi|27312029 hypothetical protein LOC145376 [Homo sapiens]
Length = 422
Score = 33.5 bits (75), Expect = 0.58
Identities = 27/81 (33%), Positives = 38/81 (46%), Gaps = 5/81 (6%)
Query: 1 MPSPQLLVLFGSQTGTAQDVSERLGREARRR---RLGCRVQALDSYP--VVNLINEPLVI 55
M SP + L S AQ+V E+ + R + V LDS P VV ++ EP +
Sbjct: 312 MRSPVMSTLLPSLREKAQNVFEKKYHQVDVRFPAEMQKHVGTLDSVPMPVVGILGEPRCL 371
Query: 56 FVCATTGQGDPPDNMKNFWRF 76
F T DP +N K+F R+
Sbjct: 372 FNPHTLHPLDPEENTKSFGRY 392
>gi|145587088 hypothetical protein LOC165186 [Homo sapiens]
Length = 1019
Score = 32.7 bits (73), Expect = 0.99
Identities = 18/35 (51%), Positives = 23/35 (65%), Gaps = 2/35 (5%)
Query: 404 VQFQTRLKEPR--RGLCSSWLASLDPGQGPVRVPL 436
+Q + +LK+ R GL +S ASLDPG GP VPL
Sbjct: 122 IQIKDKLKKRRLSEGLAASSRASLDPGGGPQGVPL 156
>gi|239753314 PREDICTED: similar to RIKEN cDNA C230030N03 [Homo
sapiens]
Length = 1183
Score = 31.2 bits (69), Expect = 2.9
Identities = 29/126 (23%), Positives = 46/126 (36%), Gaps = 18/126 (14%)
Query: 141 AVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQ 200
A +P R + +V P TE P GVP P+ + P A G
Sbjct: 715 AQEPGKRPTFSKVTSFRKGRPLATESPGGVPAPTTEGRRWGSSGPEGLPRENPPAAAGRD 774
Query: 201 EPP-----SESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGISFAAGDVVLIQPSNS 255
PP + + P P + R GP+ G+G + +GD+ PS+
Sbjct: 775 APPLHHGDASAWPEFVPQAAGDRTAGPA-------------GAGHTGTSGDLGSRGPSSE 821
Query: 256 AAHVQR 261
+ + +R
Sbjct: 822 SCNAKR 827
>gi|151301053 RNA binding motif protein 33 [Homo sapiens]
Length = 1170
Score = 31.2 bits (69), Expect = 2.9
Identities = 14/40 (35%), Positives = 21/40 (52%)
Query: 158 PPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHP 197
PPPP T + P+P++ L F Q P+ +GQ+ P
Sbjct: 484 PPPPPPTLLNSSHPVPTQSPLPFTQPGPAFNQQGQQPVFP 523
>gi|68161504 Wiskott-Aldrich syndrome protein family member 1 [Homo
sapiens]
Length = 559
Score = 30.8 bits (68), Expect = 3.8
Identities = 21/65 (32%), Positives = 25/65 (38%), Gaps = 7/65 (10%)
Query: 153 VLGLYPPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAP 212
V GL PPPP PPG+ S T+ L PS HP P P + P
Sbjct: 420 VQGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSG-------LHPTPSTAPGPHVPLMPP 472
Query: 213 MISNQ 217
+Q
Sbjct: 473 SPPSQ 477
>gi|68161502 Wiskott-Aldrich syndrome protein family member 1 [Homo
sapiens]
Length = 559
Score = 30.8 bits (68), Expect = 3.8
Identities = 21/65 (32%), Positives = 25/65 (38%), Gaps = 7/65 (10%)
Query: 153 VLGLYPPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAP 212
V GL PPPP PPG+ S T+ L PS HP P P + P
Sbjct: 420 VQGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSG-------LHPTPSTAPGPHVPLMPP 472
Query: 213 MISNQ 217
+Q
Sbjct: 473 SPPSQ 477
>gi|68161500 Wiskott-Aldrich syndrome protein family member 1 [Homo
sapiens]
Length = 559
Score = 30.8 bits (68), Expect = 3.8
Identities = 21/65 (32%), Positives = 25/65 (38%), Gaps = 7/65 (10%)
Query: 153 VLGLYPPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAP 212
V GL PPPP PPG+ S T+ L PS HP P P + P
Sbjct: 420 VQGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSG-------LHPTPSTAPGPHVPLMPP 472
Query: 213 MISNQ 217
+Q
Sbjct: 473 SPPSQ 477
>gi|4507913 Wiskott-Aldrich syndrome protein family member 1 [Homo
sapiens]
Length = 559
Score = 30.8 bits (68), Expect = 3.8
Identities = 21/65 (32%), Positives = 25/65 (38%), Gaps = 7/65 (10%)
Query: 153 VLGLYPPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAP 212
V GL PPPP PPG+ S T+ L PS HP P P + P
Sbjct: 420 VQGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSG-------LHPTPSTAPGPHVPLMPP 472
Query: 213 MISNQ 217
+Q
Sbjct: 473 SPPSQ 477
>gi|239757699 PREDICTED: hypothetical protein [Homo sapiens]
Length = 270
Score = 30.8 bits (68), Expect = 3.8
Identities = 26/89 (29%), Positives = 36/89 (40%), Gaps = 3/89 (3%)
Query: 126 PVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLFLQEAP 185
P+CL Q P ++ W L DR+LG G E PP S+
Sbjct: 79 PICLPHPQGPRPPSSS-PRWPWGLGDRLLGARASRSGPQEPPPPGSTVSRRKAG--NRPR 135
Query: 186 STGSEGQRVAHPGSQEPPSESKPFLAPMI 214
G+ G + PG+ E PS P L P++
Sbjct: 136 LRGTAGGKAQGPGNPEGPSSLLPRLLPLL 164
>gi|239756047 PREDICTED: heparan sulfate 6-O-sulfotransferase 3
[Homo sapiens]
Length = 471
Score = 30.8 bits (68), Expect = 3.8
Identities = 31/114 (27%), Positives = 45/114 (39%), Gaps = 19/114 (16%)
Query: 135 ELGPDAAVDPWLR-----DLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLFLQEA--PST 187
E GP A P R + W+R L PPP G E P G P + +E P
Sbjct: 45 EAGPPAVPGPARRAQAPPEEWERRPQLPPPPRGPPEGPRGAAAPEEED----EEPGDPRE 100
Query: 188 GSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDV-RLIEFDILGSGI 240
G E + P + P + S P P + +D+ R ++F+I G +
Sbjct: 101 GEEEEEEDEPDPEAPENGSLPRFVPRFN-------FSLKDLTRFVDFNIKGRDV 147
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.139 0.433
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,622,686
Number of Sequences: 37866
Number of extensions: 1450529
Number of successful extensions: 4361
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 42
Number of HSP's that attempted gapping in prelim test: 4248
Number of HSP's gapped (non-prelim): 91
length of query: 606
length of database: 18,247,518
effective HSP length: 108
effective length of query: 498
effective length of database: 14,157,990
effective search space: 7050679020
effective search space used: 7050679020
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.