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Search of human proteins with 221316609
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|221316609 sperm-associated cation channel 1 [Homo sapiens]
(780 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|221316609 sperm-associated cation channel 1 [Homo sapiens] 1629 0.0
gi|62122917 filaggrin family member 2 [Homo sapiens] 96 2e-19
gi|38505290 voltage-dependent calcium channel alpha 1G subunit i... 94 4e-19
gi|38505286 voltage-dependent calcium channel alpha 1G subunit i... 94 4e-19
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i... 93 8e-19
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i... 93 8e-19
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i... 93 8e-19
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i... 93 8e-19
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i... 93 8e-19
gi|38505268 voltage-dependent calcium channel alpha 1G subunit i... 93 8e-19
gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I... 93 8e-19
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I... 93 8e-19
gi|62988334 cation channel, sperm associated 4 [Homo sapiens] 92 2e-18
gi|20070163 voltage-dependent calcium channel alpha 1G subunit i... 89 1e-17
gi|38505284 voltage-dependent calcium channel alpha 1G subunit i... 89 1e-17
gi|38505282 voltage-dependent calcium channel alpha 1G subunit i... 89 1e-17
gi|38505280 voltage-dependent calcium channel alpha 1G subunit i... 89 1e-17
gi|38505278 voltage-dependent calcium channel alpha 1G subunit i... 89 1e-17
gi|38505270 voltage-dependent calcium channel alpha 1G subunit i... 89 1e-17
gi|193788732 calcium channel, voltage-dependent, L type, alpha 1... 89 2e-17
gi|193788730 calcium channel, voltage-dependent, L type, alpha 1... 89 2e-17
gi|193788728 calcium channel, voltage-dependent, L type, alpha 1... 89 2e-17
gi|193788724 calcium channel, voltage-dependent, L type, alpha 1... 89 2e-17
gi|193788720 calcium channel, voltage-dependent, L type, alpha 1... 89 2e-17
gi|120433602 calcium channel, voltage-dependent, L type, alpha 1... 89 2e-17
gi|193788548 calcium channel, voltage-dependent, L type, alpha 1... 89 2e-17
gi|193788544 calcium channel, voltage-dependent, L type, alpha 1... 89 2e-17
gi|193788542 calcium channel, voltage-dependent, L type, alpha 1... 89 2e-17
gi|193788540 calcium channel, voltage-dependent, L type, alpha 1... 89 2e-17
gi|193788538 calcium channel, voltage-dependent, L type, alpha 1... 89 2e-17
>gi|221316609 sperm-associated cation channel 1 [Homo sapiens]
Length = 780
Score = 1629 bits (4219), Expect = 0.0
Identities = 780/780 (100%), Positives = 780/780 (100%)
Query: 1 MDQNSVPEKAQNEADTNNADRFFRSHSSPPHHRPGHSRALHHYELHHHGVPHQRGESHHP 60
MDQNSVPEKAQNEADTNNADRFFRSHSSPPHHRPGHSRALHHYELHHHGVPHQRGESHHP
Sbjct: 1 MDQNSVPEKAQNEADTNNADRFFRSHSSPPHHRPGHSRALHHYELHHHGVPHQRGESHHP 60
Query: 61 PEFQDFHDQALSSHVHQSHHHSEARNHGRAHGPTGFGLAPSQGAVPSHRSYGEDYHDELQ 120
PEFQDFHDQALSSHVHQSHHHSEARNHGRAHGPTGFGLAPSQGAVPSHRSYGEDYHDELQ
Sbjct: 61 PEFQDFHDQALSSHVHQSHHHSEARNHGRAHGPTGFGLAPSQGAVPSHRSYGEDYHDELQ 120
Query: 121 RDGRRHHDGSQYGGFHQQSDSHYHRGSHHGRPQYLGENLSHYSSGVPHHGEASHHGGSYL 180
RDGRRHHDGSQYGGFHQQSDSHYHRGSHHGRPQYLGENLSHYSSGVPHHGEASHHGGSYL
Sbjct: 121 RDGRRHHDGSQYGGFHQQSDSHYHRGSHHGRPQYLGENLSHYSSGVPHHGEASHHGGSYL 180
Query: 181 PHGPNPYSESFHHSEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHGKS 240
PHGPNPYSESFHHSEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHGKS
Sbjct: 181 PHGPNPYSESFHHSEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHGKS 240
Query: 241 PHHGETISPHSSVGSYQRGISDYHSEYHQGDHHPSEYHHGDHPHHTQHHYHQTHRHRDYH 300
PHHGETISPHSSVGSYQRGISDYHSEYHQGDHHPSEYHHGDHPHHTQHHYHQTHRHRDYH
Sbjct: 241 PHHGETISPHSSVGSYQRGISDYHSEYHQGDHHPSEYHHGDHPHHTQHHYHQTHRHRDYH 300
Query: 301 QHQDHHGAYHSSYLHGDYVQSTSQLSIPHTSRSLIHDAPGPAASRTGVFPYHVAHPRGSA 360
QHQDHHGAYHSSYLHGDYVQSTSQLSIPHTSRSLIHDAPGPAASRTGVFPYHVAHPRGSA
Sbjct: 301 QHQDHHGAYHSSYLHGDYVQSTSQLSIPHTSRSLIHDAPGPAASRTGVFPYHVAHPRGSA 360
Query: 361 HSMTRSSSTIRSRVTQMSKKVHTQDISTKHSEDWGKEEGQFQKRKTGRLQRTRKKGHSTN 420
HSMTRSSSTIRSRVTQMSKKVHTQDISTKHSEDWGKEEGQFQKRKTGRLQRTRKKGHSTN
Sbjct: 361 HSMTRSSSTIRSRVTQMSKKVHTQDISTKHSEDWGKEEGQFQKRKTGRLQRTRKKGHSTN 420
Query: 421 LFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYF 480
LFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYF
Sbjct: 421 LFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYF 480
Query: 481 MALDSIFFCIYVVEALLKIIALGLSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQS 540
MALDSIFFCIYVVEALLKIIALGLSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQS
Sbjct: 481 MALDSIFFCIYVVEALLKIIALGLSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQS 540
Query: 541 LFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAV 600
LFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAV
Sbjct: 541 LFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAV 600
Query: 601 LRALFRKSDPKRFQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYF 660
LRALFRKSDPKRFQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYF
Sbjct: 601 LRALFRKSDPKRFQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYF 660
Query: 661 IFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTML 720
IFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTML
Sbjct: 661 IFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTML 720
Query: 721 KRLIEKKFGTMTEKQQELLFHYLQLVASVEQEQQKFRSQAAVIDEIVDTTFEAGEEDFRN 780
KRLIEKKFGTMTEKQQELLFHYLQLVASVEQEQQKFRSQAAVIDEIVDTTFEAGEEDFRN
Sbjct: 721 KRLIEKKFGTMTEKQQELLFHYLQLVASVEQEQQKFRSQAAVIDEIVDTTFEAGEEDFRN 780
>gi|62122917 filaggrin family member 2 [Homo sapiens]
Length = 2391
Score = 95.5 bits (236), Expect = 2e-19
Identities = 113/438 (25%), Positives = 158/438 (36%), Gaps = 77/438 (17%)
Query: 31 HHRPGHSRALHHYELHHHGVPHQ--------RGESHHPPEFQDFHDQALSSHVHQSHHHS 82
H + G + HY HHG+ Q RG H E+ D + SH H H H
Sbjct: 1696 HGQTGDTTRHAHY---HHGLTTQTGSRTTGRRGSGHS--EYSDSEGYSGVSHTHSGHTHG 1750
Query: 83 EARN------------HGRAHGPTGFGLAPSQGAVPSHRSYGEDYHDELQRDGRRHHDGS 130
+AR+ HG HG TG +H +G+ + GRR S
Sbjct: 1751 QARSQHGESESIVHERHGTIHGQTG------DTTRHAHSGHGQSTQTGSRTTGRRSSGHS 1804
Query: 131 QYG------GF----HQQSDSHYHRGSHHGRPQYL------------GENLSHYSSGVPH 168
+Y GF H + +H GS HG + + G+ H SG
Sbjct: 1805 EYSDSEGHSGFSQRPHSRGHTHGQAGSQHGESESIVDERHGTTHGQTGDTSGHSQSG--- 1861
Query: 169 HGEASHHGGSYLPHGPNPYSESFH---HSEASHL-SGLQHDESQHHQVPHRGWPHHHQVH 224
HG+++ G S + +SES HS SH SG H +++ H
Sbjct: 1862 HGQSTQSGSSTTGRRRSGHSESSDSEVHSGGSHTHSGHTHSQARSQHGESESTVHKRHQT 1921
Query: 225 HHGRSRHHEAHQHGKSPHHGETISPHSSVGSYQRGISDYHSEYHQGDHHPSEYH-HGDHP 283
HG++ H H P HG+TI S +RG HSEY + H H H
Sbjct: 1922 THGQTGDTTEHGH---PSHGQTIQTGSRTTG-RRGSG--HSEYSDSEGPSGVSHTHSGHT 1975
Query: 284 HHTQHHYHQTHRHRDYHQHQDHHGAYHSSYLHGD--YVQSTSQLSIPHTSRSLIHDAPGP 341
H ++ + +H HG + HG + QST + S R+ H
Sbjct: 1976 HGQAGSHYPESGSSVHERHGTTHGQTADTTRHGHSGHGQSTQRGSRTTGRRASGHSEYSD 2035
Query: 342 AASRTGVFPYHVAHPRGSAHSMTRSSSTIRSRVTQMSKKVHTQ-DISTKHSEDWGKEEGQ 400
+ +GV H H G A S S S V + H Q +T+H+ + Q
Sbjct: 2036 SEGHSGVSHTHSGHAHGQAGSQHGESG---SSVHERHGTTHGQTGDTTRHAHSGHGQSTQ 2092
Query: 401 FQKRKTGRLQRTRKKGHS 418
R GR R GHS
Sbjct: 2093 RGSRTAGR----RGSGHS 2106
Score = 88.6 bits (218), Expect = 2e-17
Identities = 110/405 (27%), Positives = 150/405 (37%), Gaps = 74/405 (18%)
Query: 55 GESHHPPEFQDFHDQALSSHVHQSH--HHSEARNHGRAHGPTGFGLAPSQGAVPSHRSYG 112
G SH P + H QA S H H +G+ TG G H +G
Sbjct: 1358 GVSHRPHSQEQTHSQAGSQHGESESTVHERHETTYGQTGEATGHG----------HSGHG 1407
Query: 113 EDYHDELQRDGRRHHDGSQYGGFHQQSDSHYHRGSHHGRPQYLGENLSHYSSGVPHHGEA 172
+ + GRR GS G + SDS H G H RPQ + +H +G HGE+
Sbjct: 1408 QSTQRGSRTTGRR---GS---GHSESSDSEVHSGGSH-RPQ--SQEQTHGQAG-SQHGES 1457
Query: 173 S-----HHGGSYLPHGPNPYSESFHHSEASHLS-------GLQHDESQHHQVPHRGWPHH 220
HG ++ G +HH +++ G H ES +V H G H
Sbjct: 1458 GSTVHGRHGTTHGQTGDTTRHAHYHHGKSTQRGSSTTGRRGSGHSESSDSEV-HSGGSHT 1516
Query: 221 HQVHHHGRSRHHEAHQHGKSPH---------HGET--ISPHSSVGSYQRGISDYHSEYHQ 269
H H HG+S QHG+S HG+T + HS G Q + + Q
Sbjct: 1517 HSGHTHGQS----GSQHGESESIIHDRHRITHGQTGDTTRHSYSGHEQTTQTGSRTTGRQ 1572
Query: 270 GDHHP----SEYHHGD--HPHHTQHHYHQT---HRHRDYHQHQDHHGAYH------SSYL 314
H SE H G PH +H Y Q H ++ H+ HG H + +
Sbjct: 1573 RTSHSESTDSEVHSGGSHRPHSREHTYGQAGSQHEEPEFTVHE-RHGTTHGQIGDTTGHS 1631
Query: 315 HGDYVQSTSQLSIPHTSRSLIHDAPGPAASRTGVFPYHVAHPRGSAHSMTRSSSTIRSRV 374
H + QST + S + H + +GV H H G A S S +I V
Sbjct: 1632 HSGHGQSTQRGSRTTGRQRSSHSESSDSEVHSGVSHTHTGHTHGQAGSQHGQSESI---V 1688
Query: 375 TQMSKKVHTQ-DISTKHSEDWGKEEGQFQKRKTGRLQRTRKKGHS 418
+ H Q +T+H+ Q R TGR R GHS
Sbjct: 1689 PERHGTTHGQTGDTTRHAHYHHGLTTQTGSRTTGR----RGSGHS 1729
Score = 85.5 bits (210), Expect = 2e-16
Identities = 121/435 (27%), Positives = 152/435 (34%), Gaps = 83/435 (19%)
Query: 35 GHSRALHHYELHHHGVPHQRGESHHPPEFQDFHDQALSSHVHQSHHHSEA---------- 84
GHS + H R S H E D + SH H H H +A
Sbjct: 1629 GHSHSGHGQSTQRGSRTTGRQRSSHS-ESSDSEVHSGVSHTHTGHTHGQAGSQHGQSESI 1687
Query: 85 --RNHGRAHGPTG---------FGLAPSQGAVPSHR--SYGEDYHDELQRDGRRH-HDGS 130
HG HG TG GL G+ + R S +Y D G H H G
Sbjct: 1688 VPERHGTTHGQTGDTTRHAHYHHGLTTQTGSRTTGRRGSGHSEYSDSEGYSGVSHTHSGH 1747
Query: 131 QYG---GFHQQSDS--HYHRGSHHGRPQYLGENLSHYSSGVPHHGEASHHGGSYLPHGPN 185
+G H +S+S H G+ HG+ G+ H SG HG+++ G
Sbjct: 1748 THGQARSQHGESESIVHERHGTIHGQT---GDTTRHAHSG---HGQSTQTGSRTTGR--- 1798
Query: 186 PYSESFHHSEASHLSGLQHDESQHHQVPH-RGWPHHHQVHHHGRS------RHHEAHQ-- 236
S HSE S G S Q PH RG H HG S RH H
Sbjct: 1799 ---RSSGHSEYSDSEG----HSGFSQRPHSRGHTHGQAGSQHGESESIVDERHGTTHGQT 1851
Query: 237 -----HGKSPHHGETISPHSSVGSYQRGISDYH-SEYHQGDHHPSEYHHGDHPHHTQHHY 290
H +S H T S S+ G + G S+ SE H G H H H H
Sbjct: 1852 GDTSGHSQSGHGQSTQSGSSTTGRRRSGHSESSDSEVHSGGSHT----HSGHTHSQARSQ 1907
Query: 291 HQTHRHRDYHQHQDHHG-----AYHSSYLHGDYVQSTSQLSIPHTS-RSLIHDAPGPAAS 344
H + +HQ HG H HG +Q+ S+ + S S D+ GP
Sbjct: 1908 HGESESTVHKRHQTTHGQTGDTTEHGHPSHGQTIQTGSRTTGRRGSGHSEYSDSEGP--- 1964
Query: 345 RTGVFPYHVAHPRGSAHSMTRSSSTIRSRVTQMSKKVHTQDI-STKHSEDWGKEEGQFQK 403
+GV H H G A S S S V + H Q +T+H + Q
Sbjct: 1965 -SGVSHTHSGHTHGQAGSHYPESG---SSVHERHGTTHGQTADTTRHGHSGHGQSTQRGS 2020
Query: 404 RKTGRLQRTRKKGHS 418
R TGR R GHS
Sbjct: 2021 RTTGR----RASGHS 2031
Score = 62.4 bits (150), Expect = 2e-09
Identities = 94/396 (23%), Positives = 137/396 (34%), Gaps = 52/396 (13%)
Query: 3 QNSVPEKAQNEADTNNADRFFRSHSSPPHHRPGHSRALHHYELHHHGVPHQRGESHHPPE 62
++S + Q+ + R RS S HS+ H + H H + SH+P
Sbjct: 1248 RHSQSGQGQSTQTGSRVTRRRRSSQSENSDSEVHSKVSHRHSEHIH----TQAGSHYPKS 1303
Query: 63 FQDFHDQALSSHVHQSHHHSEARNHGRAHGPTGFGLAPSQGAVPSHRSYGEDYHDELQRD 122
+ ++H R HG +G G + G+ R+ G
Sbjct: 1304 GSTVRRRQGTTHGQ--------RGDTTRHGHSGHGQSTQTGS----RTSGRQRFSHSDAT 1351
Query: 123 GRRHHDGSQYGGFHQQSDSHYHRGSHHGRPQYLGENLSHYSSGVPHHGEASHHGGSYLPH 182
H G + H Q +H GS HG + + G GEA+ HG S H
Sbjct: 1352 DSEVHSGVSHRP-HSQEQTHSQAGSQHGESESTVHERHETTYG--QTGEATGHGHS--GH 1406
Query: 183 GPNPYSESFHHSEASHLSGLQHDESQHHQVPHRGWPHHHQVHH--HGRSRHHEAHQHGKS 240
G + S + G H ES +V H G H Q HG++ QHG+S
Sbjct: 1407 GQSTQ----RGSRTTGRRGSGHSESSDSEV-HSGGSHRPQSQEQTHGQA----GSQHGES 1457
Query: 241 PHHGETISPHSSVGSYQRGISDYHSEYHQGDHHPSEYHHGDHPHHTQHHYHQTHRHRDYH 300
G T+ Q G + H+ Y HH G + H + H
Sbjct: 1458 ---GSTVHGRHGTTHGQTGDTTRHAHY----HHGKSTQRGSSTTGRRGSGHSESSDSEVH 1510
Query: 301 QHQDHHGAYHSSYLHGDYVQSTSQLSIPHTSRSLIHDAPGPAASRTGVFPYHVAHPRGSA 360
H HS + HG QS SQ S S+IHD +TG H ++
Sbjct: 1511 SGGSH---THSGHTHG---QSGSQHG---ESESIIHDRHRITHGQTGDTTRH-SYSGHEQ 1560
Query: 361 HSMTRSSSTIRSRVT---QMSKKVHTQDISTKHSED 393
+ T S +T R R + +VH+ HS +
Sbjct: 1561 TTQTGSRTTGRQRTSHSESTDSEVHSGGSHRPHSRE 1596
Score = 55.8 bits (133), Expect = 1e-07
Identities = 89/322 (27%), Positives = 114/322 (35%), Gaps = 64/322 (19%)
Query: 48 HGVPHQRGE-------SHHPPEFQDFHDQALSSHVHQSHHHSEA------------RNHG 88
HG QRG S H E+ D + SH H H H +A HG
Sbjct: 2012 HGQSTQRGSRTTGRRASGHS-EYSDSEGHSGVSHTHSGHAHGQAGSQHGESGSSVHERHG 2070
Query: 89 RAHGPTGFGLAPSQGAVPSHRSYGEDYHDELQRDGRRHHDGSQYGGFHQQSDSHYHRG-S 147
HG TG +H +G+ + GRR GS G + SDS H G S
Sbjct: 2071 TTHGQTG------DTTRHAHSGHGQSTQRGSRTAGRR---GS---GHSESSDSEVHSGVS 2118
Query: 148 H-HGRPQYLGENLSHYSSGVPHHG-EASHHG--GSYLPHGPNPYSESFHHSEASHLSGLQ 203
H H Y H SG HG + + HG G HG + + +S S +G Q
Sbjct: 2119 HTHSGHTYGQARSQHGESGSAIHGRQGTIHGQTGDTTRHGQSGHGQSTQ--TGSRTTGRQ 2176
Query: 204 ---HDESQHHQV------PHRGWPHHHQVHHHGRSRHHEAHQHGKSPHHGET--ISPHSS 252
H ES +V H G H HG+S + G + HG+T + H+
Sbjct: 2177 RSSHSESSDSEVHSEASPTHSGHTHSQAGSRHGQSGSSGHGRQGTT--HGQTGDTTRHAH 2234
Query: 253 VGSYQRGISDYHSEYHQGDHH----PSEYHH-GDHPH--HTQHHYHQTHRHRDYHQH--- 302
G Q + +G H SE H G H H H Q R H
Sbjct: 2235 YGYGQSTQRGSRTTGRRGSGHSESSDSEVHSWGSHTHSGHIQGQAGSQQRQPGSTVHGRL 2294
Query: 303 QDHHGAYHSSYLHG--DYVQST 322
+ HG + HG Y QST
Sbjct: 2295 ETTHGQTGDTTRHGHSGYGQST 2316
Score = 52.0 bits (123), Expect = 2e-06
Identities = 94/395 (23%), Positives = 127/395 (32%), Gaps = 56/395 (14%)
Query: 66 FHDQALSSHVHQSHHHSEARNHGRAHGPTGFGLAPSQGAVPSHRSYGEDYHDELQRDGRR 125
F S + E+R+H ++G G G + S G S G+ + R G
Sbjct: 897 FGQHGTGSGQYSGFGQHESRSHQSSYGQHGSGSSQSSGYGQHGSSSGQTFGFGQHRSGSG 956
Query: 126 HHDG-SQYGGFHQQSDSHYHRGSHHGRPQYLGENLSHYS-SGVPHHGEASHHGGSYLPHG 183
G Q+G QS S G+ G++ S S S HG S Y HG
Sbjct: 957 QSSGFGQHGSGSGQSSGFGQHESGSGKSSGFGQHESRSSQSNYGQHGSGSSQSSGYGQHG 1016
Query: 184 PNPYSES---FHHSEASHLSGLQHDESQHHQVPHRGWPHHHQ--------VHHHGRSRHH 232
+ + H S + SG S Q G+ H + RSR
Sbjct: 1017 SSSGQTTGFGQHRSSSGQYSGFGQHGSGSDQ--SSGFGQHGTGSGQSSGFGQYESRSRQS 1074
Query: 233 EAHQHGKSP-------HHGETISPHSSVGSYQ--RGISDYHSEYHQGDHHPSEYHHGDHP 283
QHG HG S G ++ G S +Y G S + G H
Sbjct: 1075 SYGQHGSGSSQSSGYGQHGSNSGQTSGFGQHRPGSGQSSGFGQYGSGSGQSSGF--GQHG 1132
Query: 284 HHT-------QHHYHQTHRHRDYHQHQDHHGAYHSSYLHGDYVQSTSQLSIPHTSRSLIH 336
T QH Y Y QH H T+ H S S
Sbjct: 1133 SGTGKSSGFAQHEYRS--GQSSYGQHGTGSSQSSGCGQHESGSGPTTSFG-QHVSGSDNF 1189
Query: 337 DAPGPAASRTGVFPYHVAHPRGSAHS---------MTRSSSTIRSRVTQMSKKVHTQDI- 386
+ G S +G + GS S S ST+ R + H Q I
Sbjct: 1190 SSSGQHISDSGQSTGFGQYGSGSGQSTGLGQGESQQVESGSTVHGR----QETTHGQTIN 1245
Query: 387 STKHSEDWGKEEGQFQKRKTG-RLQRTRKKGHSTN 420
+T+HS + GQ Q +TG R+ R R+ S N
Sbjct: 1246 TTRHS-----QSGQGQSTQTGSRVTRRRRSSQSEN 1275
Score = 42.0 bits (97), Expect = 0.002
Identities = 56/218 (25%), Positives = 82/218 (37%), Gaps = 31/218 (14%)
Query: 57 SHHPPEFQDFHDQALSSHVHQSHHHSEARNHGRAHGPTGFGLAPS----QGAVPSHRSYG 112
SH + H +A S H H HS+A + G +G G + G H YG
Sbjct: 2179 SHSESSDSEVHSEA--SPTHSGHTHSQAGSRHGQSGSSGHGRQGTTHGQTGDTTRHAHYG 2236
Query: 113 EDYHDELQRDGRRHHDGSQYGGFHQQSDSHYHR-GSHHGRPQYLGENLSHY-SSGVPHHG 170
Y QR R G + G + SDS H GSH G+ S G HG
Sbjct: 2237 --YGQSTQRGSRT--TGRRGSGHSESSDSEVHSWGSHTHSGHIQGQAGSQQRQPGSTVHG 2292
Query: 171 --EASH-HGGSYLPHGPNPYSESFHHSEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHG 227
E +H G HG + Y +S +G + + H Q H + HG
Sbjct: 2293 RLETTHGQTGDTTRHGHSGYGQSTQ-------TGSRSSRASHFQ------SHSSERQRHG 2339
Query: 228 RSRHHEAHQHGKSPH-HGETISPHSSVGSYQRGISDYH 264
S+ + +G + + +G T + G ++ IS+ H
Sbjct: 2340 SSQVWKHGSYGPAEYDYGHT--GYGPSGGSRKSISNSH 2375
Score = 40.8 bits (94), Expect = 0.005
Identities = 59/252 (23%), Positives = 78/252 (30%), Gaps = 32/252 (12%)
Query: 83 EARNHGRAHGPTGFGLAPSQGAVPSHRSYGEDYHDELQRDGRRHHDGS--------QYGG 134
E+R+ ++G GFG + S G YG+ Q G H+ S Q+G
Sbjct: 685 ESRSGHSSYGQHGFGSSQSSG-------YGQHGSSSGQTSGFGQHELSSGQSSSFGQHGS 737
Query: 135 FHQQSDSHYHRGSHHGRPQYLGENLSHYS-SGVPHHGEASHHGGSYLPHGPNPYSESFHH 193
QS GS G+ G++ S S H S Y HG S H
Sbjct: 738 GSGQSSGFGQHGSGSGQSSGFGQHESRSGQSSYGQHSSGSSQSSGYGQHGSRQTSGFGQH 797
Query: 194 -SEASHLSGLQHDESQHHQVPHRGWPHHHQV--------HHHGRSRHHEAHQHGKSPHHG 244
S +S +G S Q G+ H H RS QHG
Sbjct: 798 GSGSSQSTGFGQYGSGSGQ--SAGFGQHGSGSGQSSGFGQHESRSHQSSYGQHGSGSSQS 855
Query: 245 ETISPHSSVGSYQRGISDYHSEYHQ----GDH-HPSEYHHGDHPHHTQHHYHQTHRHRDY 299
H S G + S Q G H S G H T + +
Sbjct: 856 SGYGQHGSSSGQTSGFGQHRSSSGQYSGFGQHGSGSGQSSGFGQHGTGSGQYSGFGQHES 915
Query: 300 HQHQDHHGAYHS 311
HQ +G + S
Sbjct: 916 RSHQSSYGQHGS 927
Score = 40.4 bits (93), Expect = 0.006
Identities = 54/210 (25%), Positives = 76/210 (36%), Gaps = 20/210 (9%)
Query: 11 QNEADTNNADRFFRSHSSPPHHRPGHSRALHHYELHHHGVPHQRGESHHPPEFQDFHDQA 70
Q + + ++D S +SP H HS+A HG Q G S H + H Q
Sbjct: 2176 QRSSHSESSDSEVHSEASPTHSGHTHSQA-----GSRHG---QSGSSGHGRQ-GTTHGQT 2226
Query: 71 --LSSHVHQSHHHSEARNHGRAHGPTGFGLAPSQGA-VPSHRSYGEDYHDELQRDGRRHH 127
+ H H + S R R G G G + S + V S S+ H + Q ++
Sbjct: 2227 GDTTRHAHYGYGQSTQRG-SRTTGRRGSGHSESSDSEVHSWGSHTHSGHIQGQAGSQQRQ 2285
Query: 128 DGSQYGG-----FHQQSDSHYHRGSHHGRPQYLGENLSHYSSGVPHHGEASHHGGSYL-P 181
GS G Q D+ H S +G+ G S S H E HG S +
Sbjct: 2286 PGSTVHGRLETTHGQTGDTTRHGHSGYGQSTQTGSRSSRASHFQSHSSERQRHGSSQVWK 2345
Query: 182 HGP-NPYSESFHHSEASHLSGLQHDESQHH 210
HG P + H+ G + S H
Sbjct: 2346 HGSYGPAEYDYGHTGYGPSGGSRKSISNSH 2375
Score = 35.8 bits (81), Expect = 0.16
Identities = 61/261 (23%), Positives = 81/261 (31%), Gaps = 31/261 (11%)
Query: 83 EARNHGRAHGPTGFGLAPSQGAVPSHRSYGEDYHDELQRDGRRHHDGS-------QYGGF 135
E+R+ ++G G G + S G YG+ E G+ H GS QYG
Sbjct: 535 ESRSRQSSYGQHGSGSSQSSG-------YGQYGSRETSGFGQ-HGLGSGQSTGFGQYGSG 586
Query: 136 HQQSDSHYHRGSHHGRPQYLGENLSHYS-SGVPHHGEASHHGGSYLPHGPNPYSESFHH- 193
QS GS G+ G++ S S H S Y HG S H
Sbjct: 587 SGQSSGFGQHGSGSGQSSGFGQHESRSGQSSYGQHSSGSSQSSGYGQHGSRQTSGFGQHG 646
Query: 194 SEASHLSGLQHDESQHHQVPHRGWPHHHQV--------HHHGRSRHHEAHQHGKSPHHGE 245
S +S +G S Q G+ H H RS H QHG
Sbjct: 647 SGSSQSTGFGQYGSGSGQ--SSGFGQHVSGSGQSSGFGQHESRSGHSSYGQHGFGSSQSS 704
Query: 246 TISPHSSVGSYQRGISDYHSEYHQGDHHPSEYHHGDHPHHTQHHYHQTHRHRDYHQHQDH 305
H S G + Q H + + + QH+
Sbjct: 705 GYGQHGSSSGQTSGFGQHELSSGQSSSFGQHGSGSGQSSGFGQHGSGSGQSSGFGQHESR 764
Query: 306 HGAYHSSYLHGDYVQSTSQLS 326
G SSY G + +SQ S
Sbjct: 765 SG--QSSY--GQHSSGSSQSS 781
>gi|38505290 voltage-dependent calcium channel alpha 1G subunit
isoform 13 [Homo sapiens]
Length = 2243
Score = 94.4 bits (233), Expect = 4e-19
Identities = 82/326 (25%), Positives = 154/326 (47%), Gaps = 35/326 (10%)
Query: 396 KEEGQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFF 455
+EE + ++R+ RL+R KK + + FR ++ +L S + FI
Sbjct: 1524 QEEEEARRREEKRLRRLEKKRRKAQCKPYYSD-----YSRFRLLVHHLCTSHYLDLFITG 1578
Query: 456 VVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIALGLSYFF-DFWNNL 514
V+ LN V + + + + +I E + IF I+V+E++ K++A G FF D WN L
Sbjct: 1579 VIGLNVVTMAMEHYQQPQILDE-ALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQL 1637
Query: 515 DFFIMAMAVLDFLL--MQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEV 572
D I+ ++++ L ++ ++ + ++ RI++V LR RVL+ L ++ +
Sbjct: 1638 DLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRV------LRIARVLKLLKMAVGMRAL 1691
Query: 573 TGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRKSD------------PKRFQNIFTTI 620
T+ Q+LP + + +L F+F+A+ LF + F+N
Sbjct: 1692 LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAF 1751
Query: 621 FTLFTLLTLDDWSLIYMDS----RAQGAWY---IIPI-LVIYIIIQYFIFLNLVITVLVD 672
TLF + T D+W+ I D+ + Y I PI V +++ F+ +N+VI VL+
Sbjct: 1752 LTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMK 1811
Query: 673 SFQTALFKGLEKAKQERAARIQEKLL 698
+ + + E+A+ E ++ K L
Sbjct: 1812 HLEESNKEAKEEAELEAELELEMKTL 1837
Score = 77.0 bits (188), Expect = 6e-14
Identities = 80/344 (23%), Positives = 147/344 (42%), Gaps = 56/344 (16%)
Query: 426 WEKLTFLIQG-FREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALD 484
W F Q FR + + F+ + ++ LN + + + E F+ L
Sbjct: 1231 WSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLS 1290
Query: 485 S-IFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYH 538
+ IF +++ E +K++ALG +Y WN LD ++ ++V+D L+ ++
Sbjct: 1291 NYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILV------SMVS 1344
Query: 539 QSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFS 598
S +IL + + LR LR +R LR +S ++ V TL SL I I+++ +F
Sbjct: 1345 DSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1404
Query: 599 AVLRALFR----------------KSD-----------PKRFQNIFTTIFTLFTLLTLDD 631
+ LF+ KSD F N+ + +LF L + D
Sbjct: 1405 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1464
Query: 632 W-SLIYMDSRAQGA----------WYIIPILVIYIIIQYFIFLNLVITVLVDSFQTALFK 680
W ++Y A G W ++ + +I+ +F+ LN+ + V+V++F K
Sbjct: 1465 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFV-LNMFVGVVVENFH----K 1519
Query: 681 GLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLI 724
+ ++E A R +EK L + R A+ K S+ + + L+
Sbjct: 1520 CRQHQEEEEARRREEKRLRRLEKKRRKAQCKPYYSDYSRFRLLV 1563
Score = 70.5 bits (171), Expect = 6e-12
Identities = 56/251 (22%), Positives = 115/251 (45%), Gaps = 29/251 (11%)
Query: 438 EMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALL 497
+ R + S F I + +NT+ + + + E ++ + +F ++ +E LL
Sbjct: 734 DTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEIS-NIVFTSLFALEMLL 792
Query: 498 KIIALG-LSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALRA 556
K++ G Y + +N D I+ ++V + + Q ++ LR R
Sbjct: 793 KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSV--------------LRTFRL 838
Query: 557 IRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF----------- 605
+RVL+ + FL ++Q L +++ ++A +L+ +F+FS + LF
Sbjct: 839 MRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGD 898
Query: 606 RKSDPKRFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLN 664
D K F ++ I T+F +LT +DW+ ++Y + +W + + + Y +F N
Sbjct: 899 TLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLF-N 957
Query: 665 LVITVLVDSFQ 675
L++ +LV+ FQ
Sbjct: 958 LLVAILVEGFQ 968
Score = 61.6 bits (148), Expect = 3e-09
Identities = 38/124 (30%), Positives = 65/124 (52%), Gaps = 19/124 (15%)
Query: 482 ALDSIFFCIYVVEALLKIIALGL----SYFFDFWNNLDFFIMAMAVLDFLL-MQTHSFAI 536
A D F + VE ++K++ALG+ Y D WN LDFFI+ +L++ L +Q SF+
Sbjct: 119 AFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS- 177
Query: 537 YHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFL 596
++R +R +R LR ++ + S++ + L +LP + +L+L F F+
Sbjct: 178 -------------AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFI 224
Query: 597 FSAV 600
F V
Sbjct: 225 FGIV 228
Score = 32.7 bits (73), Expect = 1.3
Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 7/112 (6%)
Query: 613 FQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVD 672
F NI +F ++TL+ W I ++Y ++ II+ F +NL + V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Query: 673 SFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLI 724
F + + +++R + L ++ T +EP E +LK L+
Sbjct: 397 QFSETKQRESQLMREQRV-----RFLSNASTLASFSEPGSCYEE--LLKYLV 441
Score = 30.8 bits (68), Expect = 5.0
Identities = 25/97 (25%), Positives = 32/97 (32%), Gaps = 18/97 (18%)
Query: 194 SEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHG--KSPHHGETISPHS 251
S + L G + S HR HH VHHH HH +G ++P I
Sbjct: 466 SSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRD 525
Query: 252 SVGSYQ----------------RGISDYHSEYHQGDH 272
+ GS + G HS YH H
Sbjct: 526 ANGSRRLMLPPPSTPALSGAPPGGAESVHSFYHADCH 562
>gi|38505286 voltage-dependent calcium channel alpha 1G subunit
isoform 10 [Homo sapiens]
Length = 2266
Score = 94.4 bits (233), Expect = 4e-19
Identities = 82/326 (25%), Positives = 154/326 (47%), Gaps = 35/326 (10%)
Query: 396 KEEGQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFF 455
+EE + ++R+ RL+R KK + + FR ++ +L S + FI
Sbjct: 1547 QEEEEARRREEKRLRRLEKKRRKAQCKPYYSD-----YSRFRLLVHHLCTSHYLDLFITG 1601
Query: 456 VVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIALGLSYFF-DFWNNL 514
V+ LN V + + + + +I E + IF I+V+E++ K++A G FF D WN L
Sbjct: 1602 VIGLNVVTMAMEHYQQPQILDE-ALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQL 1660
Query: 515 DFFIMAMAVLDFLL--MQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEV 572
D I+ ++++ L ++ ++ + ++ RI++V LR RVL+ L ++ +
Sbjct: 1661 DLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRV------LRIARVLKLLKMAVGMRAL 1714
Query: 573 TGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRKSD------------PKRFQNIFTTI 620
T+ Q+LP + + +L F+F+A+ LF + F+N
Sbjct: 1715 LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAF 1774
Query: 621 FTLFTLLTLDDWSLIYMDS----RAQGAWY---IIPI-LVIYIIIQYFIFLNLVITVLVD 672
TLF + T D+W+ I D+ + Y I PI V +++ F+ +N+VI VL+
Sbjct: 1775 LTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMK 1834
Query: 673 SFQTALFKGLEKAKQERAARIQEKLL 698
+ + + E+A+ E ++ K L
Sbjct: 1835 HLEESNKEAKEEAELEAELELEMKTL 1860
Score = 77.0 bits (188), Expect = 6e-14
Identities = 80/344 (23%), Positives = 147/344 (42%), Gaps = 56/344 (16%)
Query: 426 WEKLTFLIQG-FREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALD 484
W F Q FR + + F+ + ++ LN + + + E F+ L
Sbjct: 1254 WSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLS 1313
Query: 485 S-IFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYH 538
+ IF +++ E +K++ALG +Y WN LD ++ ++V+D L+ ++
Sbjct: 1314 NYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILV------SMVS 1367
Query: 539 QSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFS 598
S +IL + + LR LR +R LR +S ++ V TL SL I I+++ +F
Sbjct: 1368 DSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1427
Query: 599 AVLRALFR----------------KSD-----------PKRFQNIFTTIFTLFTLLTLDD 631
+ LF+ KSD F N+ + +LF L + D
Sbjct: 1428 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1487
Query: 632 W-SLIYMDSRAQGA----------WYIIPILVIYIIIQYFIFLNLVITVLVDSFQTALFK 680
W ++Y A G W ++ + +I+ +F+ LN+ + V+V++F K
Sbjct: 1488 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFV-LNMFVGVVVENFH----K 1542
Query: 681 GLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLI 724
+ ++E A R +EK L + R A+ K S+ + + L+
Sbjct: 1543 CRQHQEEEEARRREEKRLRRLEKKRRKAQCKPYYSDYSRFRLLV 1586
Score = 70.5 bits (171), Expect = 6e-12
Identities = 56/251 (22%), Positives = 115/251 (45%), Gaps = 29/251 (11%)
Query: 438 EMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALL 497
+ R + S F I + +NT+ + + + E ++ + +F ++ +E LL
Sbjct: 734 DTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEIS-NIVFTSLFALEMLL 792
Query: 498 KIIALG-LSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALRA 556
K++ G Y + +N D I+ ++V + + Q ++ LR R
Sbjct: 793 KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSV--------------LRTFRL 838
Query: 557 IRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF----------- 605
+RVL+ + FL ++Q L +++ ++A +L+ +F+FS + LF
Sbjct: 839 MRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGD 898
Query: 606 RKSDPKRFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLN 664
D K F ++ I T+F +LT +DW+ ++Y + +W + + + Y +F N
Sbjct: 899 TLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLF-N 957
Query: 665 LVITVLVDSFQ 675
L++ +LV+ FQ
Sbjct: 958 LLVAILVEGFQ 968
Score = 61.6 bits (148), Expect = 3e-09
Identities = 38/124 (30%), Positives = 65/124 (52%), Gaps = 19/124 (15%)
Query: 482 ALDSIFFCIYVVEALLKIIALGL----SYFFDFWNNLDFFIMAMAVLDFLL-MQTHSFAI 536
A D F + VE ++K++ALG+ Y D WN LDFFI+ +L++ L +Q SF+
Sbjct: 119 AFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS- 177
Query: 537 YHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFL 596
++R +R +R LR ++ + S++ + L +LP + +L+L F F+
Sbjct: 178 -------------AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFI 224
Query: 597 FSAV 600
F V
Sbjct: 225 FGIV 228
Score = 32.7 bits (73), Expect = 1.3
Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 7/112 (6%)
Query: 613 FQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVD 672
F NI +F ++TL+ W I ++Y ++ II+ F +NL + V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Query: 673 SFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLI 724
F + + +++R + L ++ T +EP E +LK L+
Sbjct: 397 QFSETKQRESQLMREQRV-----RFLSNASTLASFSEPGSCYEE--LLKYLV 441
Score = 30.8 bits (68), Expect = 5.0
Identities = 25/97 (25%), Positives = 32/97 (32%), Gaps = 18/97 (18%)
Query: 194 SEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHG--KSPHHGETISPHS 251
S + L G + S HR HH VHHH HH +G ++P I
Sbjct: 466 SSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRD 525
Query: 252 SVGSYQ----------------RGISDYHSEYHQGDH 272
+ GS + G HS YH H
Sbjct: 526 ANGSRRLMLPPPSTPALSGAPPGGAESVHSFYHADCH 562
>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
isoform 3 [Homo sapiens]
Length = 2343
Score = 93.2 bits (230), Expect = 8e-19
Identities = 83/328 (25%), Positives = 156/328 (47%), Gaps = 32/328 (9%)
Query: 396 KEEGQFQKRKTGRLQRTRKKGHSTN--LFQWLWEKLTFLIQGFREMIRNLTQSLAFETFI 453
+EE + ++R+ RL+R KK S + + + FR ++ +L S + FI
Sbjct: 1524 QEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFI 1583
Query: 454 FFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIALGLSYFF-DFWN 512
V+ LN V + + + + +I E + IF I+V+E++ K++A G FF D WN
Sbjct: 1584 TGVIGLNVVTMAMEHYQQPQILDE-ALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWN 1642
Query: 513 NLDFFIMAMAVLDFLL--MQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQ 570
LD I+ ++++ L ++ ++ + ++ RI++V LR RVL+ L ++
Sbjct: 1643 QLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRV------LRIARVLKLLKMAVGMR 1696
Query: 571 EVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRKSD------------PKRFQNIFT 618
+ T+ Q+LP + + +L F+F+A+ LF + F+N
Sbjct: 1697 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGM 1756
Query: 619 TIFTLFTLLTLDDWSLIYMDS----RAQGAWY---IIPI-LVIYIIIQYFIFLNLVITVL 670
TLF + T D+W+ I D+ + Y I PI V +++ F+ +N+VI VL
Sbjct: 1757 AFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVL 1816
Query: 671 VDSFQTALFKGLEKAKQERAARIQEKLL 698
+ + + + E+A+ E ++ K L
Sbjct: 1817 MKHLEESNKEAKEEAELEAELELEMKTL 1844
Score = 75.9 bits (185), Expect = 1e-13
Identities = 79/334 (23%), Positives = 145/334 (43%), Gaps = 57/334 (17%)
Query: 426 WEKLTFLIQG-FREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALD 484
W F Q FR + + F+ + ++ LN + + + E F+ L
Sbjct: 1231 WSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLS 1290
Query: 485 S-IFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYH 538
+ IF +++ E +K++ALG +Y WN LD ++ ++V+D L+ ++
Sbjct: 1291 NYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILV------SMVS 1344
Query: 539 QSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFS 598
S +IL + + LR LR +R LR +S ++ V TL SL I I+++ +F
Sbjct: 1345 DSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1404
Query: 599 AVLRALFR----------------KSD-----------PKRFQNIFTTIFTLFTLLTLDD 631
+ LF+ KSD F N+ + +LF L + D
Sbjct: 1405 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1464
Query: 632 W-SLIYMDSRAQGA----------WYIIPILVIYIIIQYFIFLNLVITVLVDSFQTALFK 680
W ++Y A G W ++ + +I+ +F+ LN+ + V+V++F K
Sbjct: 1465 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFV-LNMFVGVVVENFH----K 1519
Query: 681 GLEKAKQERAARIQEKLLEDSLTELRAAEPKEVA 714
+ ++E A R +EK L L + R ++ K++A
Sbjct: 1520 CRQHQEEEEARRREEKRLR-RLEKKRRSKEKQMA 1552
Score = 70.5 bits (171), Expect = 6e-12
Identities = 56/251 (22%), Positives = 115/251 (45%), Gaps = 29/251 (11%)
Query: 438 EMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALL 497
+ R + S F I + +NT+ + + + E ++ + +F ++ +E LL
Sbjct: 734 DTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEIS-NIVFTSLFALEMLL 792
Query: 498 KIIALG-LSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALRA 556
K++ G Y + +N D I+ ++V + + Q ++ LR R
Sbjct: 793 KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSV--------------LRTFRL 838
Query: 557 IRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF----------- 605
+RVL+ + FL ++Q L +++ ++A +L+ +F+FS + LF
Sbjct: 839 MRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGD 898
Query: 606 RKSDPKRFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLN 664
D K F ++ I T+F +LT +DW+ ++Y + +W + + + Y +F N
Sbjct: 899 TLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLF-N 957
Query: 665 LVITVLVDSFQ 675
L++ +LV+ FQ
Sbjct: 958 LLVAILVEGFQ 968
Score = 61.6 bits (148), Expect = 3e-09
Identities = 38/124 (30%), Positives = 65/124 (52%), Gaps = 19/124 (15%)
Query: 482 ALDSIFFCIYVVEALLKIIALGL----SYFFDFWNNLDFFIMAMAVLDFLL-MQTHSFAI 536
A D F + VE ++K++ALG+ Y D WN LDFFI+ +L++ L +Q SF+
Sbjct: 119 AFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS- 177
Query: 537 YHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFL 596
++R +R +R LR ++ + S++ + L +LP + +L+L F F+
Sbjct: 178 -------------AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFI 224
Query: 597 FSAV 600
F V
Sbjct: 225 FGIV 228
Score = 32.7 bits (73), Expect = 1.3
Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 7/112 (6%)
Query: 613 FQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVD 672
F NI +F ++TL+ W I ++Y ++ II+ F +NL + V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Query: 673 SFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLI 724
F + + +++R + L ++ T +EP E +LK L+
Sbjct: 397 QFSETKQRESQLMREQRV-----RFLSNASTLASFSEPGSCYEE--LLKYLV 441
Score = 30.8 bits (68), Expect = 5.0
Identities = 25/97 (25%), Positives = 32/97 (32%), Gaps = 18/97 (18%)
Query: 194 SEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHG--KSPHHGETISPHS 251
S + L G + S HR HH VHHH HH +G ++P I
Sbjct: 466 SSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRD 525
Query: 252 SVGSYQ----------------RGISDYHSEYHQGDH 272
+ GS + G HS YH H
Sbjct: 526 ANGSRRLMLPPPSTPALSGAPPGGAESVHSFYHADCH 562
>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
isoform 12 [Homo sapiens]
Length = 2250
Score = 93.2 bits (230), Expect = 8e-19
Identities = 83/328 (25%), Positives = 156/328 (47%), Gaps = 32/328 (9%)
Query: 396 KEEGQFQKRKTGRLQRTRKKGHSTN--LFQWLWEKLTFLIQGFREMIRNLTQSLAFETFI 453
+EE + ++R+ RL+R KK S + + + FR ++ +L S + FI
Sbjct: 1524 QEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFI 1583
Query: 454 FFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIALGLSYFF-DFWN 512
V+ LN V + + + + +I E + IF I+V+E++ K++A G FF D WN
Sbjct: 1584 TGVIGLNVVTMAMEHYQQPQILDE-ALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWN 1642
Query: 513 NLDFFIMAMAVLDFLL--MQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQ 570
LD I+ ++++ L ++ ++ + ++ RI++V LR RVL+ L ++
Sbjct: 1643 QLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRV------LRIARVLKLLKMAVGMR 1696
Query: 571 EVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRKSD------------PKRFQNIFT 618
+ T+ Q+LP + + +L F+F+A+ LF + F+N
Sbjct: 1697 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGM 1756
Query: 619 TIFTLFTLLTLDDWSLIYMDS----RAQGAWY---IIPI-LVIYIIIQYFIFLNLVITVL 670
TLF + T D+W+ I D+ + Y I PI V +++ F+ +N+VI VL
Sbjct: 1757 AFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVL 1816
Query: 671 VDSFQTALFKGLEKAKQERAARIQEKLL 698
+ + + + E+A+ E ++ K L
Sbjct: 1817 MKHLEESNKEAKEEAELEAELELEMKTL 1844
Score = 75.9 bits (185), Expect = 1e-13
Identities = 79/334 (23%), Positives = 145/334 (43%), Gaps = 57/334 (17%)
Query: 426 WEKLTFLIQG-FREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALD 484
W F Q FR + + F+ + ++ LN + + + E F+ L
Sbjct: 1231 WSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLS 1290
Query: 485 S-IFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYH 538
+ IF +++ E +K++ALG +Y WN LD ++ ++V+D L+ ++
Sbjct: 1291 NYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILV------SMVS 1344
Query: 539 QSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFS 598
S +IL + + LR LR +R LR +S ++ V TL SL I I+++ +F
Sbjct: 1345 DSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1404
Query: 599 AVLRALFR----------------KSD-----------PKRFQNIFTTIFTLFTLLTLDD 631
+ LF+ KSD F N+ + +LF L + D
Sbjct: 1405 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1464
Query: 632 W-SLIYMDSRAQGA----------WYIIPILVIYIIIQYFIFLNLVITVLVDSFQTALFK 680
W ++Y A G W ++ + +I+ +F+ LN+ + V+V++F K
Sbjct: 1465 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFV-LNMFVGVVVENFH----K 1519
Query: 681 GLEKAKQERAARIQEKLLEDSLTELRAAEPKEVA 714
+ ++E A R +EK L L + R ++ K++A
Sbjct: 1520 CRQHQEEEEARRREEKRLR-RLEKKRRSKEKQMA 1552
Score = 70.5 bits (171), Expect = 6e-12
Identities = 56/251 (22%), Positives = 115/251 (45%), Gaps = 29/251 (11%)
Query: 438 EMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALL 497
+ R + S F I + +NT+ + + + E ++ + +F ++ +E LL
Sbjct: 734 DTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEIS-NIVFTSLFALEMLL 792
Query: 498 KIIALG-LSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALRA 556
K++ G Y + +N D I+ ++V + + Q ++ LR R
Sbjct: 793 KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSV--------------LRTFRL 838
Query: 557 IRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF----------- 605
+RVL+ + FL ++Q L +++ ++A +L+ +F+FS + LF
Sbjct: 839 MRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGD 898
Query: 606 RKSDPKRFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLN 664
D K F ++ I T+F +LT +DW+ ++Y + +W + + + Y +F N
Sbjct: 899 TLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLF-N 957
Query: 665 LVITVLVDSFQ 675
L++ +LV+ FQ
Sbjct: 958 LLVAILVEGFQ 968
Score = 61.6 bits (148), Expect = 3e-09
Identities = 38/124 (30%), Positives = 65/124 (52%), Gaps = 19/124 (15%)
Query: 482 ALDSIFFCIYVVEALLKIIALGL----SYFFDFWNNLDFFIMAMAVLDFLL-MQTHSFAI 536
A D F + VE ++K++ALG+ Y D WN LDFFI+ +L++ L +Q SF+
Sbjct: 119 AFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS- 177
Query: 537 YHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFL 596
++R +R +R LR ++ + S++ + L +LP + +L+L F F+
Sbjct: 178 -------------AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFI 224
Query: 597 FSAV 600
F V
Sbjct: 225 FGIV 228
Score = 32.7 bits (73), Expect = 1.3
Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 7/112 (6%)
Query: 613 FQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVD 672
F NI +F ++TL+ W I ++Y ++ II+ F +NL + V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Query: 673 SFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLI 724
F + + +++R + L ++ T +EP E +LK L+
Sbjct: 397 QFSETKQRESQLMREQRV-----RFLSNASTLASFSEPGSCYEE--LLKYLV 441
Score = 30.8 bits (68), Expect = 5.0
Identities = 25/97 (25%), Positives = 32/97 (32%), Gaps = 18/97 (18%)
Query: 194 SEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHG--KSPHHGETISPHS 251
S + L G + S HR HH VHHH HH +G ++P I
Sbjct: 466 SSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRD 525
Query: 252 SVGSYQ----------------RGISDYHSEYHQGDH 272
+ GS + G HS YH H
Sbjct: 526 ANGSRRLMLPPPSTPALSGAPPGGAESVHSFYHADCH 562
>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
isoform 5 [Homo sapiens]
Length = 2321
Score = 93.2 bits (230), Expect = 8e-19
Identities = 83/328 (25%), Positives = 156/328 (47%), Gaps = 32/328 (9%)
Query: 396 KEEGQFQKRKTGRLQRTRKKGHSTN--LFQWLWEKLTFLIQGFREMIRNLTQSLAFETFI 453
+EE + ++R+ RL+R KK S + + + FR ++ +L S + FI
Sbjct: 1547 QEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFI 1606
Query: 454 FFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIALGLSYFF-DFWN 512
V+ LN V + + + + +I E + IF I+V+E++ K++A G FF D WN
Sbjct: 1607 TGVIGLNVVTMAMEHYQQPQILDE-ALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWN 1665
Query: 513 NLDFFIMAMAVLDFLL--MQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQ 570
LD I+ ++++ L ++ ++ + ++ RI++V LR RVL+ L ++
Sbjct: 1666 QLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRV------LRIARVLKLLKMAVGMR 1719
Query: 571 EVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRKSD------------PKRFQNIFT 618
+ T+ Q+LP + + +L F+F+A+ LF + F+N
Sbjct: 1720 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGM 1779
Query: 619 TIFTLFTLLTLDDWSLIYMDS----RAQGAWY---IIPI-LVIYIIIQYFIFLNLVITVL 670
TLF + T D+W+ I D+ + Y I PI V +++ F+ +N+VI VL
Sbjct: 1780 AFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVL 1839
Query: 671 VDSFQTALFKGLEKAKQERAARIQEKLL 698
+ + + + E+A+ E ++ K L
Sbjct: 1840 MKHLEESNKEAKEEAELEAELELEMKTL 1867
Score = 75.9 bits (185), Expect = 1e-13
Identities = 79/334 (23%), Positives = 145/334 (43%), Gaps = 57/334 (17%)
Query: 426 WEKLTFLIQG-FREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALD 484
W F Q FR + + F+ + ++ LN + + + E F+ L
Sbjct: 1254 WSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLS 1313
Query: 485 S-IFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYH 538
+ IF +++ E +K++ALG +Y WN LD ++ ++V+D L+ ++
Sbjct: 1314 NYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILV------SMVS 1367
Query: 539 QSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFS 598
S +IL + + LR LR +R LR +S ++ V TL SL I I+++ +F
Sbjct: 1368 DSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1427
Query: 599 AVLRALFR----------------KSD-----------PKRFQNIFTTIFTLFTLLTLDD 631
+ LF+ KSD F N+ + +LF L + D
Sbjct: 1428 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1487
Query: 632 W-SLIYMDSRAQGA----------WYIIPILVIYIIIQYFIFLNLVITVLVDSFQTALFK 680
W ++Y A G W ++ + +I+ +F+ LN+ + V+V++F K
Sbjct: 1488 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFV-LNMFVGVVVENFH----K 1542
Query: 681 GLEKAKQERAARIQEKLLEDSLTELRAAEPKEVA 714
+ ++E A R +EK L L + R ++ K++A
Sbjct: 1543 CRQHQEEEEARRREEKRLR-RLEKKRRSKEKQMA 1575
Score = 70.5 bits (171), Expect = 6e-12
Identities = 56/251 (22%), Positives = 115/251 (45%), Gaps = 29/251 (11%)
Query: 438 EMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALL 497
+ R + S F I + +NT+ + + + E ++ + +F ++ +E LL
Sbjct: 734 DTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEIS-NIVFTSLFALEMLL 792
Query: 498 KIIALG-LSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALRA 556
K++ G Y + +N D I+ ++V + + Q ++ LR R
Sbjct: 793 KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSV--------------LRTFRL 838
Query: 557 IRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF----------- 605
+RVL+ + FL ++Q L +++ ++A +L+ +F+FS + LF
Sbjct: 839 MRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGD 898
Query: 606 RKSDPKRFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLN 664
D K F ++ I T+F +LT +DW+ ++Y + +W + + + Y +F N
Sbjct: 899 TLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLF-N 957
Query: 665 LVITVLVDSFQ 675
L++ +LV+ FQ
Sbjct: 958 LLVAILVEGFQ 968
Score = 61.6 bits (148), Expect = 3e-09
Identities = 38/124 (30%), Positives = 65/124 (52%), Gaps = 19/124 (15%)
Query: 482 ALDSIFFCIYVVEALLKIIALGL----SYFFDFWNNLDFFIMAMAVLDFLL-MQTHSFAI 536
A D F + VE ++K++ALG+ Y D WN LDFFI+ +L++ L +Q SF+
Sbjct: 119 AFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS- 177
Query: 537 YHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFL 596
++R +R +R LR ++ + S++ + L +LP + +L+L F F+
Sbjct: 178 -------------AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFI 224
Query: 597 FSAV 600
F V
Sbjct: 225 FGIV 228
Score = 32.7 bits (73), Expect = 1.3
Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 7/112 (6%)
Query: 613 FQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVD 672
F NI +F ++TL+ W I ++Y ++ II+ F +NL + V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Query: 673 SFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLI 724
F + + +++R + L ++ T +EP E +LK L+
Sbjct: 397 QFSETKQRESQLMREQRV-----RFLSNASTLASFSEPGSCYEE--LLKYLV 441
Score = 30.8 bits (68), Expect = 5.0
Identities = 25/97 (25%), Positives = 32/97 (32%), Gaps = 18/97 (18%)
Query: 194 SEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHG--KSPHHGETISPHS 251
S + L G + S HR HH VHHH HH +G ++P I
Sbjct: 466 SSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRD 525
Query: 252 SVGSYQ----------------RGISDYHSEYHQGDH 272
+ GS + G HS YH H
Sbjct: 526 ANGSRRLMLPPPSTPALSGAPPGGAESVHSFYHADCH 562
>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
isoform 7 [Homo sapiens]
Length = 2298
Score = 93.2 bits (230), Expect = 8e-19
Identities = 83/328 (25%), Positives = 156/328 (47%), Gaps = 32/328 (9%)
Query: 396 KEEGQFQKRKTGRLQRTRKKGHSTN--LFQWLWEKLTFLIQGFREMIRNLTQSLAFETFI 453
+EE + ++R+ RL+R KK S + + + FR ++ +L S + FI
Sbjct: 1524 QEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFI 1583
Query: 454 FFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIALGLSYFF-DFWN 512
V+ LN V + + + + +I E + IF I+V+E++ K++A G FF D WN
Sbjct: 1584 TGVIGLNVVTMAMEHYQQPQILDE-ALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWN 1642
Query: 513 NLDFFIMAMAVLDFLL--MQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQ 570
LD I+ ++++ L ++ ++ + ++ RI++V LR RVL+ L ++
Sbjct: 1643 QLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRV------LRIARVLKLLKMAVGMR 1696
Query: 571 EVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRKSD------------PKRFQNIFT 618
+ T+ Q+LP + + +L F+F+A+ LF + F+N
Sbjct: 1697 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGM 1756
Query: 619 TIFTLFTLLTLDDWSLIYMDS----RAQGAWY---IIPI-LVIYIIIQYFIFLNLVITVL 670
TLF + T D+W+ I D+ + Y I PI V +++ F+ +N+VI VL
Sbjct: 1757 AFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVL 1816
Query: 671 VDSFQTALFKGLEKAKQERAARIQEKLL 698
+ + + + E+A+ E ++ K L
Sbjct: 1817 MKHLEESNKEAKEEAELEAELELEMKTL 1844
Score = 75.9 bits (185), Expect = 1e-13
Identities = 79/334 (23%), Positives = 145/334 (43%), Gaps = 57/334 (17%)
Query: 426 WEKLTFLIQG-FREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALD 484
W F Q FR + + F+ + ++ LN + + + E F+ L
Sbjct: 1231 WSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLS 1290
Query: 485 S-IFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYH 538
+ IF +++ E +K++ALG +Y WN LD ++ ++V+D L+ ++
Sbjct: 1291 NYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILV------SMVS 1344
Query: 539 QSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFS 598
S +IL + + LR LR +R LR +S ++ V TL SL I I+++ +F
Sbjct: 1345 DSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1404
Query: 599 AVLRALFR----------------KSD-----------PKRFQNIFTTIFTLFTLLTLDD 631
+ LF+ KSD F N+ + +LF L + D
Sbjct: 1405 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1464
Query: 632 W-SLIYMDSRAQGA----------WYIIPILVIYIIIQYFIFLNLVITVLVDSFQTALFK 680
W ++Y A G W ++ + +I+ +F+ LN+ + V+V++F K
Sbjct: 1465 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFV-LNMFVGVVVENFH----K 1519
Query: 681 GLEKAKQERAARIQEKLLEDSLTELRAAEPKEVA 714
+ ++E A R +EK L L + R ++ K++A
Sbjct: 1520 CRQHQEEEEARRREEKRLR-RLEKKRRSKEKQMA 1552
Score = 70.5 bits (171), Expect = 6e-12
Identities = 56/251 (22%), Positives = 115/251 (45%), Gaps = 29/251 (11%)
Query: 438 EMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALL 497
+ R + S F I + +NT+ + + + E ++ + +F ++ +E LL
Sbjct: 734 DTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEIS-NIVFTSLFALEMLL 792
Query: 498 KIIALG-LSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALRA 556
K++ G Y + +N D I+ ++V + + Q ++ LR R
Sbjct: 793 KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSV--------------LRTFRL 838
Query: 557 IRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF----------- 605
+RVL+ + FL ++Q L +++ ++A +L+ +F+FS + LF
Sbjct: 839 MRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGD 898
Query: 606 RKSDPKRFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLN 664
D K F ++ I T+F +LT +DW+ ++Y + +W + + + Y +F N
Sbjct: 899 TLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLF-N 957
Query: 665 LVITVLVDSFQ 675
L++ +LV+ FQ
Sbjct: 958 LLVAILVEGFQ 968
Score = 61.6 bits (148), Expect = 3e-09
Identities = 38/124 (30%), Positives = 65/124 (52%), Gaps = 19/124 (15%)
Query: 482 ALDSIFFCIYVVEALLKIIALGL----SYFFDFWNNLDFFIMAMAVLDFLL-MQTHSFAI 536
A D F + VE ++K++ALG+ Y D WN LDFFI+ +L++ L +Q SF+
Sbjct: 119 AFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS- 177
Query: 537 YHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFL 596
++R +R +R LR ++ + S++ + L +LP + +L+L F F+
Sbjct: 178 -------------AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFI 224
Query: 597 FSAV 600
F V
Sbjct: 225 FGIV 228
Score = 32.7 bits (73), Expect = 1.3
Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 7/112 (6%)
Query: 613 FQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVD 672
F NI +F ++TL+ W I ++Y ++ II+ F +NL + V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Query: 673 SFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLI 724
F + + +++R + L ++ T +EP E +LK L+
Sbjct: 397 QFSETKQRESQLMREQRV-----RFLSNASTLASFSEPGSCYEE--LLKYLV 441
Score = 30.8 bits (68), Expect = 5.0
Identities = 25/97 (25%), Positives = 32/97 (32%), Gaps = 18/97 (18%)
Query: 194 SEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHG--KSPHHGETISPHS 251
S + L G + S HR HH VHHH HH +G ++P I
Sbjct: 466 SSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRD 525
Query: 252 SVGSYQ----------------RGISDYHSEYHQGDH 272
+ GS + G HS YH H
Sbjct: 526 ANGSRRLMLPPPSTPALSGAPPGGAESVHSFYHADCH 562
>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
isoform 9 [Homo sapiens]
Length = 2273
Score = 93.2 bits (230), Expect = 8e-19
Identities = 83/328 (25%), Positives = 156/328 (47%), Gaps = 32/328 (9%)
Query: 396 KEEGQFQKRKTGRLQRTRKKGHSTN--LFQWLWEKLTFLIQGFREMIRNLTQSLAFETFI 453
+EE + ++R+ RL+R KK S + + + FR ++ +L S + FI
Sbjct: 1547 QEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFI 1606
Query: 454 FFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIALGLSYFF-DFWN 512
V+ LN V + + + + +I E + IF I+V+E++ K++A G FF D WN
Sbjct: 1607 TGVIGLNVVTMAMEHYQQPQILDE-ALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWN 1665
Query: 513 NLDFFIMAMAVLDFLL--MQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQ 570
LD I+ ++++ L ++ ++ + ++ RI++V LR RVL+ L ++
Sbjct: 1666 QLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRV------LRIARVLKLLKMAVGMR 1719
Query: 571 EVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRKSD------------PKRFQNIFT 618
+ T+ Q+LP + + +L F+F+A+ LF + F+N
Sbjct: 1720 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGM 1779
Query: 619 TIFTLFTLLTLDDWSLIYMDS----RAQGAWY---IIPI-LVIYIIIQYFIFLNLVITVL 670
TLF + T D+W+ I D+ + Y I PI V +++ F+ +N+VI VL
Sbjct: 1780 AFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVL 1839
Query: 671 VDSFQTALFKGLEKAKQERAARIQEKLL 698
+ + + + E+A+ E ++ K L
Sbjct: 1840 MKHLEESNKEAKEEAELEAELELEMKTL 1867
Score = 75.9 bits (185), Expect = 1e-13
Identities = 79/334 (23%), Positives = 145/334 (43%), Gaps = 57/334 (17%)
Query: 426 WEKLTFLIQG-FREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALD 484
W F Q FR + + F+ + ++ LN + + + E F+ L
Sbjct: 1254 WSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLS 1313
Query: 485 S-IFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYH 538
+ IF +++ E +K++ALG +Y WN LD ++ ++V+D L+ ++
Sbjct: 1314 NYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILV------SMVS 1367
Query: 539 QSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFS 598
S +IL + + LR LR +R LR +S ++ V TL SL I I+++ +F
Sbjct: 1368 DSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1427
Query: 599 AVLRALFR----------------KSD-----------PKRFQNIFTTIFTLFTLLTLDD 631
+ LF+ KSD F N+ + +LF L + D
Sbjct: 1428 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1487
Query: 632 W-SLIYMDSRAQGA----------WYIIPILVIYIIIQYFIFLNLVITVLVDSFQTALFK 680
W ++Y A G W ++ + +I+ +F+ LN+ + V+V++F K
Sbjct: 1488 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFV-LNMFVGVVVENFH----K 1542
Query: 681 GLEKAKQERAARIQEKLLEDSLTELRAAEPKEVA 714
+ ++E A R +EK L L + R ++ K++A
Sbjct: 1543 CRQHQEEEEARRREEKRLR-RLEKKRRSKEKQMA 1575
Score = 70.5 bits (171), Expect = 6e-12
Identities = 56/251 (22%), Positives = 115/251 (45%), Gaps = 29/251 (11%)
Query: 438 EMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALL 497
+ R + S F I + +NT+ + + + E ++ + +F ++ +E LL
Sbjct: 734 DTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEIS-NIVFTSLFALEMLL 792
Query: 498 KIIALG-LSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALRA 556
K++ G Y + +N D I+ ++V + + Q ++ LR R
Sbjct: 793 KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSV--------------LRTFRL 838
Query: 557 IRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF----------- 605
+RVL+ + FL ++Q L +++ ++A +L+ +F+FS + LF
Sbjct: 839 MRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGD 898
Query: 606 RKSDPKRFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLN 664
D K F ++ I T+F +LT +DW+ ++Y + +W + + + Y +F N
Sbjct: 899 TLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLF-N 957
Query: 665 LVITVLVDSFQ 675
L++ +LV+ FQ
Sbjct: 958 LLVAILVEGFQ 968
Score = 61.6 bits (148), Expect = 3e-09
Identities = 38/124 (30%), Positives = 65/124 (52%), Gaps = 19/124 (15%)
Query: 482 ALDSIFFCIYVVEALLKIIALGL----SYFFDFWNNLDFFIMAMAVLDFLL-MQTHSFAI 536
A D F + VE ++K++ALG+ Y D WN LDFFI+ +L++ L +Q SF+
Sbjct: 119 AFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS- 177
Query: 537 YHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFL 596
++R +R +R LR ++ + S++ + L +LP + +L+L F F+
Sbjct: 178 -------------AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFI 224
Query: 597 FSAV 600
F V
Sbjct: 225 FGIV 228
Score = 32.7 bits (73), Expect = 1.3
Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 7/112 (6%)
Query: 613 FQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVD 672
F NI +F ++TL+ W I ++Y ++ II+ F +NL + V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Query: 673 SFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLI 724
F + + +++R + L ++ T +EP E +LK L+
Sbjct: 397 QFSETKQRESQLMREQRV-----RFLSNASTLASFSEPGSCYEE--LLKYLV 441
Score = 30.8 bits (68), Expect = 5.0
Identities = 25/97 (25%), Positives = 32/97 (32%), Gaps = 18/97 (18%)
Query: 194 SEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHG--KSPHHGETISPHS 251
S + L G + S HR HH VHHH HH +G ++P I
Sbjct: 466 SSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRD 525
Query: 252 SVGSYQ----------------RGISDYHSEYHQGDH 272
+ GS + G HS YH H
Sbjct: 526 ANGSRRLMLPPPSTPALSGAPPGGAESVHSFYHADCH 562
>gi|38505268 voltage-dependent calcium channel alpha 1G subunit
isoform 14 [Homo sapiens]
Length = 2171
Score = 93.2 bits (230), Expect = 8e-19
Identities = 83/328 (25%), Positives = 156/328 (47%), Gaps = 32/328 (9%)
Query: 396 KEEGQFQKRKTGRLQRTRKKGHSTN--LFQWLWEKLTFLIQGFREMIRNLTQSLAFETFI 453
+EE + ++R+ RL+R KK S + + + FR ++ +L S + FI
Sbjct: 1524 QEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFI 1583
Query: 454 FFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIALGLSYFF-DFWN 512
V+ LN V + + + + +I E + IF I+V+E++ K++A G FF D WN
Sbjct: 1584 TGVIGLNVVTMAMEHYQQPQILDE-ALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWN 1642
Query: 513 NLDFFIMAMAVLDFLL--MQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQ 570
LD I+ ++++ L ++ ++ + ++ RI++V LR RVL+ L ++
Sbjct: 1643 QLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRV------LRIARVLKLLKMAVGMR 1696
Query: 571 EVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRKSD------------PKRFQNIFT 618
+ T+ Q+LP + + +L F+F+A+ LF + F+N
Sbjct: 1697 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGM 1756
Query: 619 TIFTLFTLLTLDDWSLIYMDS----RAQGAWY---IIPI-LVIYIIIQYFIFLNLVITVL 670
TLF + T D+W+ I D+ + Y I PI V +++ F+ +N+VI VL
Sbjct: 1757 AFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVL 1816
Query: 671 VDSFQTALFKGLEKAKQERAARIQEKLL 698
+ + + + E+A+ E ++ K L
Sbjct: 1817 MKHLEESNKEAKEEAELEAELELEMKTL 1844
Score = 75.9 bits (185), Expect = 1e-13
Identities = 79/334 (23%), Positives = 145/334 (43%), Gaps = 57/334 (17%)
Query: 426 WEKLTFLIQG-FREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALD 484
W F Q FR + + F+ + ++ LN + + + E F+ L
Sbjct: 1231 WSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLS 1290
Query: 485 S-IFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYH 538
+ IF +++ E +K++ALG +Y WN LD ++ ++V+D L+ ++
Sbjct: 1291 NYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILV------SMVS 1344
Query: 539 QSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFS 598
S +IL + + LR LR +R LR +S ++ V TL SL I I+++ +F
Sbjct: 1345 DSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1404
Query: 599 AVLRALFR----------------KSD-----------PKRFQNIFTTIFTLFTLLTLDD 631
+ LF+ KSD F N+ + +LF L + D
Sbjct: 1405 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1464
Query: 632 W-SLIYMDSRAQGA----------WYIIPILVIYIIIQYFIFLNLVITVLVDSFQTALFK 680
W ++Y A G W ++ + +I+ +F+ LN+ + V+V++F K
Sbjct: 1465 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFV-LNMFVGVVVENFH----K 1519
Query: 681 GLEKAKQERAARIQEKLLEDSLTELRAAEPKEVA 714
+ ++E A R +EK L L + R ++ K++A
Sbjct: 1520 CRQHQEEEEARRREEKRLR-RLEKKRRSKEKQMA 1552
Score = 70.5 bits (171), Expect = 6e-12
Identities = 56/251 (22%), Positives = 115/251 (45%), Gaps = 29/251 (11%)
Query: 438 EMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALL 497
+ R + S F I + +NT+ + + + E ++ + +F ++ +E LL
Sbjct: 734 DTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEIS-NIVFTSLFALEMLL 792
Query: 498 KIIALG-LSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALRA 556
K++ G Y + +N D I+ ++V + + Q ++ LR R
Sbjct: 793 KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSV--------------LRTFRL 838
Query: 557 IRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF----------- 605
+RVL+ + FL ++Q L +++ ++A +L+ +F+FS + LF
Sbjct: 839 MRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGD 898
Query: 606 RKSDPKRFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLN 664
D K F ++ I T+F +LT +DW+ ++Y + +W + + + Y +F N
Sbjct: 899 TLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLF-N 957
Query: 665 LVITVLVDSFQ 675
L++ +LV+ FQ
Sbjct: 958 LLVAILVEGFQ 968
Score = 61.6 bits (148), Expect = 3e-09
Identities = 38/124 (30%), Positives = 65/124 (52%), Gaps = 19/124 (15%)
Query: 482 ALDSIFFCIYVVEALLKIIALGL----SYFFDFWNNLDFFIMAMAVLDFLL-MQTHSFAI 536
A D F + VE ++K++ALG+ Y D WN LDFFI+ +L++ L +Q SF+
Sbjct: 119 AFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS- 177
Query: 537 YHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFL 596
++R +R +R LR ++ + S++ + L +LP + +L+L F F+
Sbjct: 178 -------------AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFI 224
Query: 597 FSAV 600
F V
Sbjct: 225 FGIV 228
Score = 32.7 bits (73), Expect = 1.3
Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 7/112 (6%)
Query: 613 FQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVD 672
F NI +F ++TL+ W I ++Y ++ II+ F +NL + V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Query: 673 SFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLI 724
F + + +++R + L ++ T +EP E +LK L+
Sbjct: 397 QFSETKQRESQLMREQRV-----RFLSNASTLASFSEPGSCYEE--LLKYLV 441
Score = 30.8 bits (68), Expect = 5.0
Identities = 25/97 (25%), Positives = 32/97 (32%), Gaps = 18/97 (18%)
Query: 194 SEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHG--KSPHHGETISPHS 251
S + L G + S HR HH VHHH HH +G ++P I
Sbjct: 466 SSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRD 525
Query: 252 SVGSYQ----------------RGISDYHSEYHQGDH 272
+ GS + G HS YH H
Sbjct: 526 ANGSRRLMLPPPSTPALSGAPPGGAESVHSFYHADCH 562
>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform b [Homo sapiens]
Length = 2188
Score = 93.2 bits (230), Expect = 8e-19
Identities = 79/325 (24%), Positives = 152/325 (46%), Gaps = 38/325 (11%)
Query: 396 KEEGQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFF 455
+E + ++R+ RL+R KK + T+ R +I ++ S + FI F
Sbjct: 1406 QEAEEARRREEKRLRRLEKKRRKAQRLPYY---ATYCHT--RLLIHSMCTSHYLDIFITF 1460
Query: 456 VVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIALGLSYFF-DFWNNL 514
++CLN V + + + + E + +F ++V+EA+LK++A GL FF D WN L
Sbjct: 1461 IICLNVVTMSLEHYNQPTSL-ETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQL 1519
Query: 515 DFFIMAMAVLDFLL--MQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEV 572
D I+ ++V+ L ++ ++ + ++ RI++V LR RVL+ L T ++ +
Sbjct: 1520 DLAIVLLSVMGITLEEIEINAALPINPTIIRIMRV------LRIARVLKLLKMATGMRAL 1573
Query: 573 TGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRK------------SDPKRFQNIFTTI 620
T+ Q+LP + + +L F+++A+ LF K S F+N
Sbjct: 1574 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAF 1633
Query: 621 FTLFTLLTLDDWSLIYMD----------SRAQGAWYIIPI-LVIYIIIQYFIFLNLVITV 669
TLF + T D+W+ I D S ++ P+ V +++ F+ +N+V+ V
Sbjct: 1634 LTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAV 1693
Query: 670 LVDSFQTALFKGLEKAKQERAARIQ 694
L+ + + E A+ + ++
Sbjct: 1694 LMKHLDDSNKEAQEDAEMDAELELE 1718
Score = 72.4 bits (176), Expect = 2e-12
Identities = 115/522 (22%), Positives = 199/522 (38%), Gaps = 107/522 (20%)
Query: 243 HGETISPHSSVGSYQRGISDYHSEYHQGDHHPSEYH-HGDHPHHTQHHYHQTHRHRDYHQ 301
H + H S+ S +RG E + P H H HH H H HRHR
Sbjct: 961 HKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHR---- 1016
Query: 302 HQDHHGAYHSSYLHGDYVQSTSQLSIPHTSRSLIHDAPGPAASRTGVFPYHVAHPRGS-- 359
H R+L D + + P AHPR +
Sbjct: 1017 ---------------------------HHRRTLSLDNRD-SVDLAELVPAVGAHPRAAWR 1048
Query: 360 AHSMTRSSSTIRSRVTQMSKKVHTQDISTKHSE--DWGKEEGQFQKRKTGRLQRTRKKGH 417
A R+ ++K D+ TK + D G++E + R+ +K
Sbjct: 1049 AAGPAPGHEDCNGRMPSIAK-----DVFTKMGDRGDRGEDEEEIDYTLCFRV----RKMI 1099
Query: 418 STNLFQWL-----WEKLTFLIQG-FREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAE 471
W W F + FR + + + F+ + + LN + + +
Sbjct: 1100 DVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQI 1159
Query: 472 VEIRGEWYFMALDS-IFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLD 525
E F+ + + IF I+V E LK+++LGL +Y WN LD F++ ++++D
Sbjct: 1160 EAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIID 1219
Query: 526 FLLMQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAA 585
++ + +IL V + LR LR +R LR +S ++ V TL SL I
Sbjct: 1220 IVVSLASAGGA------KILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGN 1273
Query: 586 ILILMFTCLFLFSAVLRALFR----------------KSD-----------PKRFQNIFT 618
I+++ +F + LF+ +SD F N+
Sbjct: 1274 IVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQ 1333
Query: 619 TIFTLFTLLTLDDW-SLIY--MDSRA--------QGAWYIIPILVIYIIIQYFIFLNLVI 667
+ +LF L + D W +++Y +D+ A W ++ + +I+ +F+ LN+ +
Sbjct: 1334 ALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFV-LNMFV 1392
Query: 668 TVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAE 709
V+V++F K + + E A R +EK L + R A+
Sbjct: 1393 GVVVENFH----KCRQHQEAEEARRREEKRLRRLEKKRRKAQ 1430
Score = 69.7 bits (169), Expect = 1e-11
Identities = 52/252 (20%), Positives = 112/252 (44%), Gaps = 28/252 (11%)
Query: 437 REMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEAL 496
R +R + S F I + +NTV + + + E + +F ++ +E +
Sbjct: 595 RAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTN-ILEICNVVFTSMFALEMI 653
Query: 497 LKIIALGL-SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALR 555
LK+ A GL Y + +N D I+ +++ + + ++ LR R
Sbjct: 654 LKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSV--------------LRTFR 699
Query: 556 AIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF---------- 605
+RVL+ + F+ +++ L +++ ++A +L+ +F+FS + +F
Sbjct: 700 LLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDT 759
Query: 606 --RKSDPKRFQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYFIFL 663
D K F ++ I T+F +LT +DW+++ + A + + V + ++
Sbjct: 760 GDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLF 819
Query: 664 NLVITVLVDSFQ 675
NL++ +LV+ FQ
Sbjct: 820 NLLVAILVEGFQ 831
Score = 55.8 bits (133), Expect = 1e-07
Identities = 40/160 (25%), Positives = 77/160 (48%), Gaps = 22/160 (13%)
Query: 449 FETFIFFVVCLNTVML-VAQTFAEVEIRGEW--YFMALDSIFFCIYVVEALLKIIALGL- 504
FE V+ LN V L + Q +++ + D F + +E +LK++ALG+
Sbjct: 81 FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140
Query: 505 ---SYFFDFWNNLDFFIMAMAVLDFLL-MQTHSFAIYHQSLFRILKVFKSLRALRAIRVL 560
Y D WN LDFFI+ ++++ L +Q + + ++R +R +R L
Sbjct: 141 GKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLS--------------AIRTVRVLRPL 186
Query: 561 RRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAV 600
+ ++ + S++ + L +LP + +L+L F F+F +
Sbjct: 187 KAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGII 226
Score = 33.5 bits (75), Expect = 0.78
Identities = 25/104 (24%), Positives = 41/104 (39%), Gaps = 6/104 (5%)
Query: 613 FQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVD 672
F NI +F ++TL+ W I ++Y ++ II+ F +NL + V+
Sbjct: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 399
Query: 673 SFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASE 716
F K ++ R Q + S T AEP + E
Sbjct: 400 QFSET------KQREHRLMLEQRQRYLSSSTVASYAEPGDCYEE 437
>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform a [Homo sapiens]
Length = 2223
Score = 93.2 bits (230), Expect = 8e-19
Identities = 79/325 (24%), Positives = 152/325 (46%), Gaps = 38/325 (11%)
Query: 396 KEEGQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFF 455
+E + ++R+ RL+R KK + T+ R +I ++ S + FI F
Sbjct: 1441 QEAEEARRREEKRLRRLEKKRRKAQRLPYY---ATYCHT--RLLIHSMCTSHYLDIFITF 1495
Query: 456 VVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIALGLSYFF-DFWNNL 514
++CLN V + + + + E + +F ++V+EA+LK++A GL FF D WN L
Sbjct: 1496 IICLNVVTMSLEHYNQPTSL-ETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQL 1554
Query: 515 DFFIMAMAVLDFLL--MQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEV 572
D I+ ++V+ L ++ ++ + ++ RI++V LR RVL+ L T ++ +
Sbjct: 1555 DLAIVLLSVMGITLEEIEINAALPINPTIIRIMRV------LRIARVLKLLKMATGMRAL 1608
Query: 573 TGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRK------------SDPKRFQNIFTTI 620
T+ Q+LP + + +L F+++A+ LF K S F+N
Sbjct: 1609 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAF 1668
Query: 621 FTLFTLLTLDDWSLIYMD----------SRAQGAWYIIPI-LVIYIIIQYFIFLNLVITV 669
TLF + T D+W+ I D S ++ P+ V +++ F+ +N+V+ V
Sbjct: 1669 LTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAV 1728
Query: 670 LVDSFQTALFKGLEKAKQERAARIQ 694
L+ + + E A+ + ++
Sbjct: 1729 LMKHLDDSNKEAQEDAEMDAELELE 1753
Score = 74.3 bits (181), Expect = 4e-13
Identities = 87/434 (20%), Positives = 165/434 (38%), Gaps = 63/434 (14%)
Query: 270 GDHHPSEYHHGDHPHHTQHHYHQTHRHRDYHQHQDHHGAYHSSYLHGDYV----QSTSQL 325
G P+ G H +H++ +T D +H G+ H LHG S +L
Sbjct: 468 GPEAPAPAKPGPHAKEPRHYHGKTKGQGDEGRHL---GSRHCQTLHGPASPGNDHSGREL 524
Query: 326 SIPH-----TSRSLIHDAPGPAASRTGVFP--YHVAHPRGSAHSMTRSSSTIRSRVTQMS 378
H T +L+ P AS P H R S T S +
Sbjct: 525 CPQHSPLDATPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAG 584
Query: 379 KKVHTQDISTKHSEDWGKEEGQFQKRKTGRLQRTRKKGHSTNLFQWL----WEKLTFLIQ 434
+ + SED E L + ++ + WL W +
Sbjct: 585 GEDEADGDGARSSEDGASSE----------LGKEEEEEEQADGAVWLCGDVWRET----- 629
Query: 435 GFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVE 494
R +R + S F I + +NTV + + + E + +F ++ +E
Sbjct: 630 --RAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTN-ILEICNVVFTSMFALE 686
Query: 495 ALLKIIALGL-SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRA 553
+LK+ A GL Y + +N D I+ +++ + + ++ LR
Sbjct: 687 MILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSV--------------LRT 732
Query: 554 LRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF-------- 605
R +RVL+ + F+ +++ L +++ ++A +L+ +F+FS + +F
Sbjct: 733 FRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRT 792
Query: 606 ----RKSDPKRFQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYFI 661
D K F ++ I T+F +LT +DW+++ + A + + V + ++
Sbjct: 793 DTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYV 852
Query: 662 FLNLVITVLVDSFQ 675
NL++ +LV+ FQ
Sbjct: 853 LFNLLVAILVEGFQ 866
Score = 72.4 bits (176), Expect = 2e-12
Identities = 115/522 (22%), Positives = 199/522 (38%), Gaps = 107/522 (20%)
Query: 243 HGETISPHSSVGSYQRGISDYHSEYHQGDHHPSEYH-HGDHPHHTQHHYHQTHRHRDYHQ 301
H + H S+ S +RG E + P H H HH H H HRHR
Sbjct: 996 HKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHR---- 1051
Query: 302 HQDHHGAYHSSYLHGDYVQSTSQLSIPHTSRSLIHDAPGPAASRTGVFPYHVAHPRGS-- 359
H R+L D + + P AHPR +
Sbjct: 1052 ---------------------------HHRRTLSLDNRD-SVDLAELVPAVGAHPRAAWR 1083
Query: 360 AHSMTRSSSTIRSRVTQMSKKVHTQDISTKHSE--DWGKEEGQFQKRKTGRLQRTRKKGH 417
A R+ ++K D+ TK + D G++E + R+ +K
Sbjct: 1084 AAGPAPGHEDCNGRMPSIAK-----DVFTKMGDRGDRGEDEEEIDYTLCFRV----RKMI 1134
Query: 418 STNLFQWL-----WEKLTFLIQG-FREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAE 471
W W F + FR + + + F+ + + LN + + +
Sbjct: 1135 DVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQI 1194
Query: 472 VEIRGEWYFMALDS-IFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLD 525
E F+ + + IF I+V E LK+++LGL +Y WN LD F++ ++++D
Sbjct: 1195 EAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIID 1254
Query: 526 FLLMQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAA 585
++ + +IL V + LR LR +R LR +S ++ V TL SL I
Sbjct: 1255 IVVSLASAGGA------KILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGN 1308
Query: 586 ILILMFTCLFLFSAVLRALFR----------------KSD-----------PKRFQNIFT 618
I+++ +F + LF+ +SD F N+
Sbjct: 1309 IVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQ 1368
Query: 619 TIFTLFTLLTLDDW-SLIY--MDSRA--------QGAWYIIPILVIYIIIQYFIFLNLVI 667
+ +LF L + D W +++Y +D+ A W ++ + +I+ +F+ LN+ +
Sbjct: 1369 ALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFV-LNMFV 1427
Query: 668 TVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAE 709
V+V++F K + + E A R +EK L + R A+
Sbjct: 1428 GVVVENFH----KCRQHQEAEEARRREEKRLRRLEKKRRKAQ 1465
Score = 55.8 bits (133), Expect = 1e-07
Identities = 40/160 (25%), Positives = 77/160 (48%), Gaps = 22/160 (13%)
Query: 449 FETFIFFVVCLNTVML-VAQTFAEVEIRGEW--YFMALDSIFFCIYVVEALLKIIALGL- 504
FE V+ LN V L + Q +++ + D F + +E +LK++ALG+
Sbjct: 81 FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140
Query: 505 ---SYFFDFWNNLDFFIMAMAVLDFLL-MQTHSFAIYHQSLFRILKVFKSLRALRAIRVL 560
Y D WN LDFFI+ ++++ L +Q + + ++R +R +R L
Sbjct: 141 GKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLS--------------AIRTVRVLRPL 186
Query: 561 RRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAV 600
+ ++ + S++ + L +LP + +L+L F F+F +
Sbjct: 187 KAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGII 226
Score = 33.5 bits (75), Expect = 0.78
Identities = 25/104 (24%), Positives = 41/104 (39%), Gaps = 6/104 (5%)
Query: 613 FQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVD 672
F NI +F ++TL+ W I ++Y ++ II+ F +NL + V+
Sbjct: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 399
Query: 673 SFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASE 716
F K ++ R Q + S T AEP + E
Sbjct: 400 QFSET------KQREHRLMLEQRQRYLSSSTVASYAEPGDCYEE 437
>gi|62988334 cation channel, sperm associated 4 [Homo sapiens]
Length = 472
Score = 92.0 bits (227), Expect = 2e-18
Identities = 71/269 (26%), Positives = 130/269 (48%), Gaps = 23/269 (8%)
Query: 426 WEKLTFLIQGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDS 485
W+ F+ + I+ L + AF+ + ++ +N + + +T + ++ + F +D
Sbjct: 74 WDMQEFITHMY---IKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDD 130
Query: 486 IFFCIYVVEALLKIIALGLSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRIL 545
I I + E LL + ++ D WN L+F I+ + +L F + + + +I +
Sbjct: 131 IVLTILLCEVLLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINY------- 183
Query: 546 KVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF 605
+LRALR + V + L + V + QS+P +A I++L+ + +FS LF
Sbjct: 184 ----TLRALRLVHVCMAVEPLARIIRV---ILQSVPDMANIMVLILFFMLVFSVFGVTLF 236
Query: 606 RKSDPKRFQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPI-----LVIYIIIQYF 660
PK FQNI ++TLF +T D W IY D + + Y + I I+I I F
Sbjct: 237 GAFVPKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAF 296
Query: 661 IFLNLVITVLVDSFQTALFKGLEKAKQER 689
I +NL + V+ + + + K E+ +Q+R
Sbjct: 297 IGINLFVIVVTTNLE-QMMKAGEQGQQQR 324
>gi|20070163 voltage-dependent calcium channel alpha 1G subunit
isoform 1 [Homo sapiens]
Length = 2377
Score = 89.4 bits (220), Expect = 1e-17
Identities = 74/286 (25%), Positives = 138/286 (48%), Gaps = 30/286 (10%)
Query: 436 FREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEA 495
FR ++ +L S + FI V+ LN V + + + + +I E + IF I+V+E+
Sbjct: 1600 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDE-ALKICNYIFTVIFVLES 1658
Query: 496 LLKIIALGLSYFF-DFWNNLDFFIMAMAVLDFLL--MQTHSFAIYHQSLFRILKVFKSLR 552
+ K++A G FF D WN LD I+ ++++ L ++ ++ + ++ RI++V
Sbjct: 1659 VFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRV----- 1713
Query: 553 ALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRKSD--- 609
LR RVL+ L ++ + T+ Q+LP + + +L F+F+A+ LF +
Sbjct: 1714 -LRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDE 1772
Query: 610 ---------PKRFQNIFTTIFTLFTLLTLDDWSLIYMDS----RAQGAWY---IIPI-LV 652
F+N TLF + T D+W+ I D+ + Y I PI V
Sbjct: 1773 THPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFV 1832
Query: 653 IYIIIQYFIFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLL 698
+++ F+ +N+VI VL+ + + + E+A+ E ++ K L
Sbjct: 1833 SFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTL 1878
Score = 73.6 bits (179), Expect = 7e-13
Identities = 75/318 (23%), Positives = 136/318 (42%), Gaps = 56/318 (17%)
Query: 426 WEKLTFLIQG-FREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALD 484
W F Q FR + + F+ + ++ LN + + + E F+ L
Sbjct: 1254 WSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLS 1313
Query: 485 S-IFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYH 538
+ IF +++ E +K++ALG +Y WN LD ++ ++V+D L+ ++
Sbjct: 1314 NYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILV------SMVS 1367
Query: 539 QSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFS 598
S +IL + + LR LR +R LR +S ++ V TL SL I I+++ +F
Sbjct: 1368 DSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1427
Query: 599 AVLRALFR----------------KSD-----------PKRFQNIFTTIFTLFTLLTLDD 631
+ LF+ KSD F N+ + +LF L + D
Sbjct: 1428 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1487
Query: 632 W-SLIYMDSRAQGA----------WYIIPILVIYIIIQYFIFLNLVITVLVDSFQTALFK 680
W ++Y A G W ++ + +I+ +F+ LN+ + V+V++F K
Sbjct: 1488 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFV-LNMFVGVVVENFH----K 1542
Query: 681 GLEKAKQERAARIQEKLL 698
+ ++E A R +EK L
Sbjct: 1543 CRQHQEEEEARRREEKRL 1560
Score = 70.5 bits (171), Expect = 6e-12
Identities = 56/251 (22%), Positives = 115/251 (45%), Gaps = 29/251 (11%)
Query: 438 EMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALL 497
+ R + S F I + +NT+ + + + E ++ + +F ++ +E LL
Sbjct: 734 DTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEIS-NIVFTSLFALEMLL 792
Query: 498 KIIALG-LSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALRA 556
K++ G Y + +N D I+ ++V + + Q ++ LR R
Sbjct: 793 KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSV--------------LRTFRL 838
Query: 557 IRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF----------- 605
+RVL+ + FL ++Q L +++ ++A +L+ +F+FS + LF
Sbjct: 839 MRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGD 898
Query: 606 RKSDPKRFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLN 664
D K F ++ I T+F +LT +DW+ ++Y + +W + + + Y +F N
Sbjct: 899 TLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLF-N 957
Query: 665 LVITVLVDSFQ 675
L++ +LV+ FQ
Sbjct: 958 LLVAILVEGFQ 968
Score = 61.6 bits (148), Expect = 3e-09
Identities = 38/124 (30%), Positives = 65/124 (52%), Gaps = 19/124 (15%)
Query: 482 ALDSIFFCIYVVEALLKIIALGL----SYFFDFWNNLDFFIMAMAVLDFLL-MQTHSFAI 536
A D F + VE ++K++ALG+ Y D WN LDFFI+ +L++ L +Q SF+
Sbjct: 119 AFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS- 177
Query: 537 YHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFL 596
++R +R +R LR ++ + S++ + L +LP + +L+L F F+
Sbjct: 178 -------------AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFI 224
Query: 597 FSAV 600
F V
Sbjct: 225 FGIV 228
Score = 32.7 bits (73), Expect = 1.3
Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 7/112 (6%)
Query: 613 FQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVD 672
F NI +F ++TL+ W I ++Y ++ II+ F +NL + V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Query: 673 SFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLI 724
F + + +++R + L ++ T +EP E +LK L+
Sbjct: 397 QFSETKQRESQLMREQRV-----RFLSNASTLASFSEPGSCYEE--LLKYLV 441
Score = 30.8 bits (68), Expect = 5.0
Identities = 25/97 (25%), Positives = 32/97 (32%), Gaps = 18/97 (18%)
Query: 194 SEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHG--KSPHHGETISPHS 251
S + L G + S HR HH VHHH HH +G ++P I
Sbjct: 466 SSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRD 525
Query: 252 SVGSYQ----------------RGISDYHSEYHQGDH 272
+ GS + G HS YH H
Sbjct: 526 ANGSRRLMLPPPSTPALSGAPPGGAESVHSFYHADCH 562
>gi|38505284 voltage-dependent calcium channel alpha 1G subunit
isoform 4 [Homo sapiens]
Length = 2332
Score = 89.4 bits (220), Expect = 1e-17
Identities = 74/286 (25%), Positives = 138/286 (48%), Gaps = 30/286 (10%)
Query: 436 FREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEA 495
FR ++ +L S + FI V+ LN V + + + + +I E + IF I+V+E+
Sbjct: 1600 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDE-ALKICNYIFTVIFVLES 1658
Query: 496 LLKIIALGLSYFF-DFWNNLDFFIMAMAVLDFLL--MQTHSFAIYHQSLFRILKVFKSLR 552
+ K++A G FF D WN LD I+ ++++ L ++ ++ + ++ RI++V
Sbjct: 1659 VFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRV----- 1713
Query: 553 ALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRKSD--- 609
LR RVL+ L ++ + T+ Q+LP + + +L F+F+A+ LF +
Sbjct: 1714 -LRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDE 1772
Query: 610 ---------PKRFQNIFTTIFTLFTLLTLDDWSLIYMDS----RAQGAWY---IIPI-LV 652
F+N TLF + T D+W+ I D+ + Y I PI V
Sbjct: 1773 THPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFV 1832
Query: 653 IYIIIQYFIFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLL 698
+++ F+ +N+VI VL+ + + + E+A+ E ++ K L
Sbjct: 1833 SFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTL 1878
Score = 73.6 bits (179), Expect = 7e-13
Identities = 75/318 (23%), Positives = 136/318 (42%), Gaps = 56/318 (17%)
Query: 426 WEKLTFLIQG-FREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALD 484
W F Q FR + + F+ + ++ LN + + + E F+ L
Sbjct: 1254 WSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLS 1313
Query: 485 S-IFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYH 538
+ IF +++ E +K++ALG +Y WN LD ++ ++V+D L+ ++
Sbjct: 1314 NYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILV------SMVS 1367
Query: 539 QSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFS 598
S +IL + + LR LR +R LR +S ++ V TL SL I I+++ +F
Sbjct: 1368 DSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1427
Query: 599 AVLRALFR----------------KSD-----------PKRFQNIFTTIFTLFTLLTLDD 631
+ LF+ KSD F N+ + +LF L + D
Sbjct: 1428 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1487
Query: 632 W-SLIYMDSRAQGA----------WYIIPILVIYIIIQYFIFLNLVITVLVDSFQTALFK 680
W ++Y A G W ++ + +I+ +F+ LN+ + V+V++F K
Sbjct: 1488 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFV-LNMFVGVVVENFH----K 1542
Query: 681 GLEKAKQERAARIQEKLL 698
+ ++E A R +EK L
Sbjct: 1543 CRQHQEEEEARRREEKRL 1560
Score = 70.5 bits (171), Expect = 6e-12
Identities = 56/251 (22%), Positives = 115/251 (45%), Gaps = 29/251 (11%)
Query: 438 EMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALL 497
+ R + S F I + +NT+ + + + E ++ + +F ++ +E LL
Sbjct: 734 DTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEIS-NIVFTSLFALEMLL 792
Query: 498 KIIALG-LSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALRA 556
K++ G Y + +N D I+ ++V + + Q ++ LR R
Sbjct: 793 KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSV--------------LRTFRL 838
Query: 557 IRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF----------- 605
+RVL+ + FL ++Q L +++ ++A +L+ +F+FS + LF
Sbjct: 839 MRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGD 898
Query: 606 RKSDPKRFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLN 664
D K F ++ I T+F +LT +DW+ ++Y + +W + + + Y +F N
Sbjct: 899 TLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLF-N 957
Query: 665 LVITVLVDSFQ 675
L++ +LV+ FQ
Sbjct: 958 LLVAILVEGFQ 968
Score = 61.6 bits (148), Expect = 3e-09
Identities = 38/124 (30%), Positives = 65/124 (52%), Gaps = 19/124 (15%)
Query: 482 ALDSIFFCIYVVEALLKIIALGL----SYFFDFWNNLDFFIMAMAVLDFLL-MQTHSFAI 536
A D F + VE ++K++ALG+ Y D WN LDFFI+ +L++ L +Q SF+
Sbjct: 119 AFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS- 177
Query: 537 YHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFL 596
++R +R +R LR ++ + S++ + L +LP + +L+L F F+
Sbjct: 178 -------------AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFI 224
Query: 597 FSAV 600
F V
Sbjct: 225 FGIV 228
Score = 32.7 bits (73), Expect = 1.3
Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 7/112 (6%)
Query: 613 FQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVD 672
F NI +F ++TL+ W I ++Y ++ II+ F +NL + V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Query: 673 SFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLI 724
F + + +++R + L ++ T +EP E +LK L+
Sbjct: 397 QFSETKQRESQLMREQRV-----RFLSNASTLASFSEPGSCYEE--LLKYLV 441
Score = 30.8 bits (68), Expect = 5.0
Identities = 25/97 (25%), Positives = 32/97 (32%), Gaps = 18/97 (18%)
Query: 194 SEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHG--KSPHHGETISPHS 251
S + L G + S HR HH VHHH HH +G ++P I
Sbjct: 466 SSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRD 525
Query: 252 SVGSYQ----------------RGISDYHSEYHQGDH 272
+ GS + G HS YH H
Sbjct: 526 ANGSRRLMLPPPSTPALSGAPPGGAESVHSFYHADCH 562
>gi|38505282 voltage-dependent calcium channel alpha 1G subunit
isoform 8 [Homo sapiens]
Length = 2284
Score = 89.4 bits (220), Expect = 1e-17
Identities = 74/286 (25%), Positives = 138/286 (48%), Gaps = 30/286 (10%)
Query: 436 FREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEA 495
FR ++ +L S + FI V+ LN V + + + + +I E + IF I+V+E+
Sbjct: 1600 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDE-ALKICNYIFTVIFVLES 1658
Query: 496 LLKIIALGLSYFF-DFWNNLDFFIMAMAVLDFLL--MQTHSFAIYHQSLFRILKVFKSLR 552
+ K++A G FF D WN LD I+ ++++ L ++ ++ + ++ RI++V
Sbjct: 1659 VFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRV----- 1713
Query: 553 ALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRKSD--- 609
LR RVL+ L ++ + T+ Q+LP + + +L F+F+A+ LF +
Sbjct: 1714 -LRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDE 1772
Query: 610 ---------PKRFQNIFTTIFTLFTLLTLDDWSLIYMDS----RAQGAWY---IIPI-LV 652
F+N TLF + T D+W+ I D+ + Y I PI V
Sbjct: 1773 THPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFV 1832
Query: 653 IYIIIQYFIFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLL 698
+++ F+ +N+VI VL+ + + + E+A+ E ++ K L
Sbjct: 1833 SFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTL 1878
Score = 73.6 bits (179), Expect = 7e-13
Identities = 75/318 (23%), Positives = 136/318 (42%), Gaps = 56/318 (17%)
Query: 426 WEKLTFLIQG-FREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALD 484
W F Q FR + + F+ + ++ LN + + + E F+ L
Sbjct: 1254 WSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLS 1313
Query: 485 S-IFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYH 538
+ IF +++ E +K++ALG +Y WN LD ++ ++V+D L+ ++
Sbjct: 1314 NYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILV------SMVS 1367
Query: 539 QSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFS 598
S +IL + + LR LR +R LR +S ++ V TL SL I I+++ +F
Sbjct: 1368 DSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1427
Query: 599 AVLRALFR----------------KSD-----------PKRFQNIFTTIFTLFTLLTLDD 631
+ LF+ KSD F N+ + +LF L + D
Sbjct: 1428 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1487
Query: 632 W-SLIYMDSRAQGA----------WYIIPILVIYIIIQYFIFLNLVITVLVDSFQTALFK 680
W ++Y A G W ++ + +I+ +F+ LN+ + V+V++F K
Sbjct: 1488 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFV-LNMFVGVVVENFH----K 1542
Query: 681 GLEKAKQERAARIQEKLL 698
+ ++E A R +EK L
Sbjct: 1543 CRQHQEEEEARRREEKRL 1560
Score = 70.5 bits (171), Expect = 6e-12
Identities = 56/251 (22%), Positives = 115/251 (45%), Gaps = 29/251 (11%)
Query: 438 EMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALL 497
+ R + S F I + +NT+ + + + E ++ + +F ++ +E LL
Sbjct: 734 DTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEIS-NIVFTSLFALEMLL 792
Query: 498 KIIALG-LSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALRA 556
K++ G Y + +N D I+ ++V + + Q ++ LR R
Sbjct: 793 KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSV--------------LRTFRL 838
Query: 557 IRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF----------- 605
+RVL+ + FL ++Q L +++ ++A +L+ +F+FS + LF
Sbjct: 839 MRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGD 898
Query: 606 RKSDPKRFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLN 664
D K F ++ I T+F +LT +DW+ ++Y + +W + + + Y +F N
Sbjct: 899 TLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLF-N 957
Query: 665 LVITVLVDSFQ 675
L++ +LV+ FQ
Sbjct: 958 LLVAILVEGFQ 968
Score = 61.6 bits (148), Expect = 3e-09
Identities = 38/124 (30%), Positives = 65/124 (52%), Gaps = 19/124 (15%)
Query: 482 ALDSIFFCIYVVEALLKIIALGL----SYFFDFWNNLDFFIMAMAVLDFLL-MQTHSFAI 536
A D F + VE ++K++ALG+ Y D WN LDFFI+ +L++ L +Q SF+
Sbjct: 119 AFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS- 177
Query: 537 YHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFL 596
++R +R +R LR ++ + S++ + L +LP + +L+L F F+
Sbjct: 178 -------------AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFI 224
Query: 597 FSAV 600
F V
Sbjct: 225 FGIV 228
Score = 32.7 bits (73), Expect = 1.3
Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 7/112 (6%)
Query: 613 FQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVD 672
F NI +F ++TL+ W I ++Y ++ II+ F +NL + V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Query: 673 SFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLI 724
F + + +++R + L ++ T +EP E +LK L+
Sbjct: 397 QFSETKQRESQLMREQRV-----RFLSNASTLASFSEPGSCYEE--LLKYLV 441
Score = 30.8 bits (68), Expect = 5.0
Identities = 25/97 (25%), Positives = 32/97 (32%), Gaps = 18/97 (18%)
Query: 194 SEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHG--KSPHHGETISPHS 251
S + L G + S HR HH VHHH HH +G ++P I
Sbjct: 466 SSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRD 525
Query: 252 SVGSYQ----------------RGISDYHSEYHQGDH 272
+ GS + G HS YH H
Sbjct: 526 ANGSRRLMLPPPSTPALSGAPPGGAESVHSFYHADCH 562
>gi|38505280 voltage-dependent calcium channel alpha 1G subunit
isoform 6 [Homo sapiens]
Length = 2306
Score = 89.4 bits (220), Expect = 1e-17
Identities = 74/286 (25%), Positives = 138/286 (48%), Gaps = 30/286 (10%)
Query: 436 FREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEA 495
FR ++ +L S + FI V+ LN V + + + + +I E + IF I+V+E+
Sbjct: 1577 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDE-ALKICNYIFTVIFVLES 1635
Query: 496 LLKIIALGLSYFF-DFWNNLDFFIMAMAVLDFLL--MQTHSFAIYHQSLFRILKVFKSLR 552
+ K++A G FF D WN LD I+ ++++ L ++ ++ + ++ RI++V
Sbjct: 1636 VFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRV----- 1690
Query: 553 ALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRKSD--- 609
LR RVL+ L ++ + T+ Q+LP + + +L F+F+A+ LF +
Sbjct: 1691 -LRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDE 1749
Query: 610 ---------PKRFQNIFTTIFTLFTLLTLDDWSLIYMDS----RAQGAWY---IIPI-LV 652
F+N TLF + T D+W+ I D+ + Y I PI V
Sbjct: 1750 THPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFV 1809
Query: 653 IYIIIQYFIFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLL 698
+++ F+ +N+VI VL+ + + + E+A+ E ++ K L
Sbjct: 1810 SFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTL 1855
Score = 73.6 bits (179), Expect = 7e-13
Identities = 75/318 (23%), Positives = 136/318 (42%), Gaps = 56/318 (17%)
Query: 426 WEKLTFLIQG-FREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALD 484
W F Q FR + + F+ + ++ LN + + + E F+ L
Sbjct: 1231 WSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLS 1290
Query: 485 S-IFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYH 538
+ IF +++ E +K++ALG +Y WN LD ++ ++V+D L+ ++
Sbjct: 1291 NYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILV------SMVS 1344
Query: 539 QSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFS 598
S +IL + + LR LR +R LR +S ++ V TL SL I I+++ +F
Sbjct: 1345 DSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1404
Query: 599 AVLRALFR----------------KSD-----------PKRFQNIFTTIFTLFTLLTLDD 631
+ LF+ KSD F N+ + +LF L + D
Sbjct: 1405 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1464
Query: 632 W-SLIYMDSRAQGA----------WYIIPILVIYIIIQYFIFLNLVITVLVDSFQTALFK 680
W ++Y A G W ++ + +I+ +F+ LN+ + V+V++F K
Sbjct: 1465 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFV-LNMFVGVVVENFH----K 1519
Query: 681 GLEKAKQERAARIQEKLL 698
+ ++E A R +EK L
Sbjct: 1520 CRQHQEEEEARRREEKRL 1537
Score = 70.5 bits (171), Expect = 6e-12
Identities = 56/251 (22%), Positives = 115/251 (45%), Gaps = 29/251 (11%)
Query: 438 EMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALL 497
+ R + S F I + +NT+ + + + E ++ + +F ++ +E LL
Sbjct: 734 DTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEIS-NIVFTSLFALEMLL 792
Query: 498 KIIALG-LSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALRA 556
K++ G Y + +N D I+ ++V + + Q ++ LR R
Sbjct: 793 KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSV--------------LRTFRL 838
Query: 557 IRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF----------- 605
+RVL+ + FL ++Q L +++ ++A +L+ +F+FS + LF
Sbjct: 839 MRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGD 898
Query: 606 RKSDPKRFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLN 664
D K F ++ I T+F +LT +DW+ ++Y + +W + + + Y +F N
Sbjct: 899 TLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLF-N 957
Query: 665 LVITVLVDSFQ 675
L++ +LV+ FQ
Sbjct: 958 LLVAILVEGFQ 968
Score = 61.6 bits (148), Expect = 3e-09
Identities = 38/124 (30%), Positives = 65/124 (52%), Gaps = 19/124 (15%)
Query: 482 ALDSIFFCIYVVEALLKIIALGL----SYFFDFWNNLDFFIMAMAVLDFLL-MQTHSFAI 536
A D F + VE ++K++ALG+ Y D WN LDFFI+ +L++ L +Q SF+
Sbjct: 119 AFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS- 177
Query: 537 YHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFL 596
++R +R +R LR ++ + S++ + L +LP + +L+L F F+
Sbjct: 178 -------------AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFI 224
Query: 597 FSAV 600
F V
Sbjct: 225 FGIV 228
Score = 32.7 bits (73), Expect = 1.3
Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 7/112 (6%)
Query: 613 FQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVD 672
F NI +F ++TL+ W I ++Y ++ II+ F +NL + V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Query: 673 SFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLI 724
F + + +++R + L ++ T +EP E +LK L+
Sbjct: 397 QFSETKQRESQLMREQRV-----RFLSNASTLASFSEPGSCYEE--LLKYLV 441
Score = 30.8 bits (68), Expect = 5.0
Identities = 25/97 (25%), Positives = 32/97 (32%), Gaps = 18/97 (18%)
Query: 194 SEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHG--KSPHHGETISPHS 251
S + L G + S HR HH VHHH HH +G ++P I
Sbjct: 466 SSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRD 525
Query: 252 SVGSYQ----------------RGISDYHSEYHQGDH 272
+ GS + G HS YH H
Sbjct: 526 ANGSRRLMLPPPSTPALSGAPPGGAESVHSFYHADCH 562
>gi|38505278 voltage-dependent calcium channel alpha 1G subunit
isoform 11 [Homo sapiens]
Length = 2261
Score = 89.4 bits (220), Expect = 1e-17
Identities = 74/286 (25%), Positives = 138/286 (48%), Gaps = 30/286 (10%)
Query: 436 FREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEA 495
FR ++ +L S + FI V+ LN V + + + + +I E + IF I+V+E+
Sbjct: 1577 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDE-ALKICNYIFTVIFVLES 1635
Query: 496 LLKIIALGLSYFF-DFWNNLDFFIMAMAVLDFLL--MQTHSFAIYHQSLFRILKVFKSLR 552
+ K++A G FF D WN LD I+ ++++ L ++ ++ + ++ RI++V
Sbjct: 1636 VFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRV----- 1690
Query: 553 ALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRKSD--- 609
LR RVL+ L ++ + T+ Q+LP + + +L F+F+A+ LF +
Sbjct: 1691 -LRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDE 1749
Query: 610 ---------PKRFQNIFTTIFTLFTLLTLDDWSLIYMDS----RAQGAWY---IIPI-LV 652
F+N TLF + T D+W+ I D+ + Y I PI V
Sbjct: 1750 THPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFV 1809
Query: 653 IYIIIQYFIFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLL 698
+++ F+ +N+VI VL+ + + + E+A+ E ++ K L
Sbjct: 1810 SFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTL 1855
Score = 73.6 bits (179), Expect = 7e-13
Identities = 75/318 (23%), Positives = 136/318 (42%), Gaps = 56/318 (17%)
Query: 426 WEKLTFLIQG-FREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALD 484
W F Q FR + + F+ + ++ LN + + + E F+ L
Sbjct: 1231 WSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLS 1290
Query: 485 S-IFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYH 538
+ IF +++ E +K++ALG +Y WN LD ++ ++V+D L+ ++
Sbjct: 1291 NYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILV------SMVS 1344
Query: 539 QSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFS 598
S +IL + + LR LR +R LR +S ++ V TL SL I I+++ +F
Sbjct: 1345 DSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1404
Query: 599 AVLRALFR----------------KSD-----------PKRFQNIFTTIFTLFTLLTLDD 631
+ LF+ KSD F N+ + +LF L + D
Sbjct: 1405 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1464
Query: 632 W-SLIYMDSRAQGA----------WYIIPILVIYIIIQYFIFLNLVITVLVDSFQTALFK 680
W ++Y A G W ++ + +I+ +F+ LN+ + V+V++F K
Sbjct: 1465 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFV-LNMFVGVVVENFH----K 1519
Query: 681 GLEKAKQERAARIQEKLL 698
+ ++E A R +EK L
Sbjct: 1520 CRQHQEEEEARRREEKRL 1537
Score = 70.5 bits (171), Expect = 6e-12
Identities = 56/251 (22%), Positives = 115/251 (45%), Gaps = 29/251 (11%)
Query: 438 EMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALL 497
+ R + S F I + +NT+ + + + E ++ + +F ++ +E LL
Sbjct: 734 DTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEIS-NIVFTSLFALEMLL 792
Query: 498 KIIALG-LSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALRA 556
K++ G Y + +N D I+ ++V + + Q ++ LR R
Sbjct: 793 KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSV--------------LRTFRL 838
Query: 557 IRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF----------- 605
+RVL+ + FL ++Q L +++ ++A +L+ +F+FS + LF
Sbjct: 839 MRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGD 898
Query: 606 RKSDPKRFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLN 664
D K F ++ I T+F +LT +DW+ ++Y + +W + + + Y +F N
Sbjct: 899 TLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLF-N 957
Query: 665 LVITVLVDSFQ 675
L++ +LV+ FQ
Sbjct: 958 LLVAILVEGFQ 968
Score = 61.6 bits (148), Expect = 3e-09
Identities = 38/124 (30%), Positives = 65/124 (52%), Gaps = 19/124 (15%)
Query: 482 ALDSIFFCIYVVEALLKIIALGL----SYFFDFWNNLDFFIMAMAVLDFLL-MQTHSFAI 536
A D F + VE ++K++ALG+ Y D WN LDFFI+ +L++ L +Q SF+
Sbjct: 119 AFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS- 177
Query: 537 YHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFL 596
++R +R +R LR ++ + S++ + L +LP + +L+L F F+
Sbjct: 178 -------------AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFI 224
Query: 597 FSAV 600
F V
Sbjct: 225 FGIV 228
Score = 32.7 bits (73), Expect = 1.3
Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 7/112 (6%)
Query: 613 FQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVD 672
F NI +F ++TL+ W I ++Y ++ II+ F +NL + V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Query: 673 SFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLI 724
F + + +++R + L ++ T +EP E +LK L+
Sbjct: 397 QFSETKQRESQLMREQRV-----RFLSNASTLASFSEPGSCYEE--LLKYLV 441
Score = 30.8 bits (68), Expect = 5.0
Identities = 25/97 (25%), Positives = 32/97 (32%), Gaps = 18/97 (18%)
Query: 194 SEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHG--KSPHHGETISPHS 251
S + L G + S HR HH VHHH HH +G ++P I
Sbjct: 466 SSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRD 525
Query: 252 SVGSYQ----------------RGISDYHSEYHQGDH 272
+ GS + G HS YH H
Sbjct: 526 ANGSRRLMLPPPSTPALSGAPPGGAESVHSFYHADCH 562
>gi|38505270 voltage-dependent calcium channel alpha 1G subunit
isoform 2 [Homo sapiens]
Length = 2354
Score = 89.4 bits (220), Expect = 1e-17
Identities = 74/286 (25%), Positives = 138/286 (48%), Gaps = 30/286 (10%)
Query: 436 FREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEA 495
FR ++ +L S + FI V+ LN V + + + + +I E + IF I+V+E+
Sbjct: 1577 FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDE-ALKICNYIFTVIFVLES 1635
Query: 496 LLKIIALGLSYFF-DFWNNLDFFIMAMAVLDFLL--MQTHSFAIYHQSLFRILKVFKSLR 552
+ K++A G FF D WN LD I+ ++++ L ++ ++ + ++ RI++V
Sbjct: 1636 VFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRV----- 1690
Query: 553 ALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRKSD--- 609
LR RVL+ L ++ + T+ Q+LP + + +L F+F+A+ LF +
Sbjct: 1691 -LRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDE 1749
Query: 610 ---------PKRFQNIFTTIFTLFTLLTLDDWSLIYMDS----RAQGAWY---IIPI-LV 652
F+N TLF + T D+W+ I D+ + Y I PI V
Sbjct: 1750 THPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFV 1809
Query: 653 IYIIIQYFIFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLL 698
+++ F+ +N+VI VL+ + + + E+A+ E ++ K L
Sbjct: 1810 SFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTL 1855
Score = 73.6 bits (179), Expect = 7e-13
Identities = 75/318 (23%), Positives = 136/318 (42%), Gaps = 56/318 (17%)
Query: 426 WEKLTFLIQG-FREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALD 484
W F Q FR + + F+ + ++ LN + + + E F+ L
Sbjct: 1231 WSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLS 1290
Query: 485 S-IFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYH 538
+ IF +++ E +K++ALG +Y WN LD ++ ++V+D L+ ++
Sbjct: 1291 NYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILV------SMVS 1344
Query: 539 QSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFS 598
S +IL + + LR LR +R LR +S ++ V TL SL I I+++ +F
Sbjct: 1345 DSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1404
Query: 599 AVLRALFR----------------KSD-----------PKRFQNIFTTIFTLFTLLTLDD 631
+ LF+ KSD F N+ + +LF L + D
Sbjct: 1405 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1464
Query: 632 W-SLIYMDSRAQGA----------WYIIPILVIYIIIQYFIFLNLVITVLVDSFQTALFK 680
W ++Y A G W ++ + +I+ +F+ LN+ + V+V++F K
Sbjct: 1465 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFV-LNMFVGVVVENFH----K 1519
Query: 681 GLEKAKQERAARIQEKLL 698
+ ++E A R +EK L
Sbjct: 1520 CRQHQEEEEARRREEKRL 1537
Score = 70.5 bits (171), Expect = 6e-12
Identities = 56/251 (22%), Positives = 115/251 (45%), Gaps = 29/251 (11%)
Query: 438 EMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALL 497
+ R + S F I + +NT+ + + + E ++ + +F ++ +E LL
Sbjct: 734 DTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEIS-NIVFTSLFALEMLL 792
Query: 498 KIIALG-LSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALRA 556
K++ G Y + +N D I+ ++V + + Q ++ LR R
Sbjct: 793 KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSV--------------LRTFRL 838
Query: 557 IRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF----------- 605
+RVL+ + FL ++Q L +++ ++A +L+ +F+FS + LF
Sbjct: 839 MRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGD 898
Query: 606 RKSDPKRFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLN 664
D K F ++ I T+F +LT +DW+ ++Y + +W + + + Y +F N
Sbjct: 899 TLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLF-N 957
Query: 665 LVITVLVDSFQ 675
L++ +LV+ FQ
Sbjct: 958 LLVAILVEGFQ 968
Score = 61.6 bits (148), Expect = 3e-09
Identities = 38/124 (30%), Positives = 65/124 (52%), Gaps = 19/124 (15%)
Query: 482 ALDSIFFCIYVVEALLKIIALGL----SYFFDFWNNLDFFIMAMAVLDFLL-MQTHSFAI 536
A D F + VE ++K++ALG+ Y D WN LDFFI+ +L++ L +Q SF+
Sbjct: 119 AFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS- 177
Query: 537 YHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFL 596
++R +R +R LR ++ + S++ + L +LP + +L+L F F+
Sbjct: 178 -------------AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFI 224
Query: 597 FSAV 600
F V
Sbjct: 225 FGIV 228
Score = 32.7 bits (73), Expect = 1.3
Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 7/112 (6%)
Query: 613 FQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVD 672
F NI +F ++TL+ W I ++Y ++ II+ F +NL + V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Query: 673 SFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLI 724
F + + +++R + L ++ T +EP E +LK L+
Sbjct: 397 QFSETKQRESQLMREQRV-----RFLSNASTLASFSEPGSCYEE--LLKYLV 441
Score = 30.8 bits (68), Expect = 5.0
Identities = 25/97 (25%), Positives = 32/97 (32%), Gaps = 18/97 (18%)
Query: 194 SEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHG--KSPHHGETISPHS 251
S + L G + S HR HH VHHH HH +G ++P I
Sbjct: 466 SSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRD 525
Query: 252 SVGSYQ----------------RGISDYHSEYHQGDH 272
+ GS + G HS YH H
Sbjct: 526 ANGSRRLMLPPPSTPALSGAPPGGAESVHSFYHADCH 562
>gi|193788732 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 5 [Homo sapiens]
Length = 2166
Score = 89.0 bits (219), Expect = 2e-17
Identities = 79/306 (25%), Positives = 145/306 (47%), Gaps = 27/306 (8%)
Query: 437 REMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEAL 496
R R +S F + F+V LNT+ + ++ + + E A + ++ E L
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA-NKALLALFTAEML 572
Query: 497 LKIIALGL-SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALR 555
LK+ +LGL +YF +N D F++ +L+ +L++T + S+ LR +R
Sbjct: 573 LKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISV---------LRCVR 623
Query: 556 AIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF--------RK 607
+R+ + + S+ + +L S+ SIA++L+L+F + +FS + LF +
Sbjct: 624 LLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQ 683
Query: 608 SDPKRFQNIFTTIFTLFTLLTLDDW-SLIYMDSRAQGAWYIIPILV-IYIIIQY----FI 661
+ F N ++ T+F +LT +DW S++Y A G +LV IY II + +I
Sbjct: 684 TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYI 743
Query: 662 FLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLK 721
LN+ + + VD+ A + L A++E + K L + + + E E + G +
Sbjct: 744 LLNVFLAIAVDNLADA--ESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKE 801
Query: 722 RLIEKK 727
IE K
Sbjct: 802 EKIELK 807
Score = 62.0 bits (149), Expect = 2e-09
Identities = 79/380 (20%), Positives = 146/380 (38%), Gaps = 82/380 (21%)
Query: 380 KVHTQDISTKHSED---------WGKEEGQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLT 430
K++ D+ +ED G+E+ + + G R + H + E
Sbjct: 820 KINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 431 FLI----QGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSI 486
F I FR + F I F + L+++ L A+ + D +
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 487 FFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSL 541
F I+ +E LK+ A G S+ +++N LD +++++++ F + +
Sbjct: 940 FTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS---------- 989
Query: 542 FRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVL 601
+ V K LR LR +R LR ++ ++ V + ++ +I I+I+ F+F+ +
Sbjct: 990 --AINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIG 1047
Query: 602 RALFRK-----SDPKR----------------------------------FQNIFTTIFT 622
LF+ SD + F N+ +
Sbjct: 1048 VQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMA 1107
Query: 623 LFTLLTLDDW-SLIY--MDSRAQ--GAWY-----IIPILVIYIIIQYFIFLNLVITVLVD 672
LFT+ T + W L+Y +DS + G Y I +IYIII F +N+ + ++
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 673 SFQ---TALFKGLEKAKQER 689
+FQ +K E K +R
Sbjct: 1168 TFQEQGEQEYKNCELDKNQR 1187
Score = 59.7 bits (143), Expect = 1e-08
Identities = 71/277 (25%), Positives = 118/277 (42%), Gaps = 64/277 (23%)
Query: 483 LDSIFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIY 537
++ +F I+ VEA LK+IA GL +Y + WN LDF I+ + + +L Q + A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQA-TKADG 220
Query: 538 HQSLFRILKVF--KSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLF 595
+L F K+LRA R +R LR +S + S+Q V ++ +++ + I +L+ +
Sbjct: 221 ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 280
Query: 596 LFSAVLRALF------------------RKSDPK-------------------------- 611
+++ + LF + DP
Sbjct: 281 IYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPK 340
Query: 612 ----RFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLV 666
F N + T+F +T++ W+ ++Y + A G + V III F LNLV
Sbjct: 341 HGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLV 400
Query: 667 ITVLVDSFQTALFKGLEKAKQE---RAARIQEKLLED 700
+ VL F K EKAK + R +++L ED
Sbjct: 401 LGVLSGEFS----KEREKAKARGDFQKLREKQQLEED 433
Score = 57.0 bits (136), Expect = 7e-08
Identities = 60/297 (20%), Positives = 120/297 (40%), Gaps = 69/297 (23%)
Query: 443 LTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIAL 502
+ S FE +F ++ LNT+ L Q + + + L+ +F ++ VE +LK+IA
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQ-SCLFKIAMNILNMLFTGLFTVEMILKLIAF 1273
Query: 503 G-LSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSL---------- 551
YF D WN DF I+ +++D +L +T+ + + F L V S+
Sbjct: 1274 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNP 1333
Query: 552 -----------------------RALRAIRVLRRLSFLTSVQEVTGTL---GQSLPSIAA 585
R R +R+++ LS ++ + T Q+LP +A
Sbjct: 1334 AEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1393
Query: 586 ILILMFTCLFLFSAVLRALFRK---------SDPKRFQNIFTTIFTLFTLLTLDDWSLIY 636
+++++F F+++ + +F K + FQ + LF T + W I
Sbjct: 1394 LIVMLF---FIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIM 1450
Query: 637 M-------------------DSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVDSF 674
+ G+ + + + + ++ F+ +NL + V++D+F
Sbjct: 1451 LACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1507
>gi|193788730 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 4 [Homo sapiens]
Length = 2173
Score = 89.0 bits (219), Expect = 2e-17
Identities = 79/306 (25%), Positives = 145/306 (47%), Gaps = 27/306 (8%)
Query: 437 REMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEAL 496
R R +S F + F+V LNT+ + ++ + + E A + ++ E L
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA-NKALLALFTAEML 572
Query: 497 LKIIALGL-SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALR 555
LK+ +LGL +YF +N D F++ +L+ +L++T + S+ LR +R
Sbjct: 573 LKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISV---------LRCVR 623
Query: 556 AIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF--------RK 607
+R+ + + S+ + +L S+ SIA++L+L+F + +FS + LF +
Sbjct: 624 LLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQ 683
Query: 608 SDPKRFQNIFTTIFTLFTLLTLDDW-SLIYMDSRAQGAWYIIPILV-IYIIIQY----FI 661
+ F N ++ T+F +LT +DW S++Y A G +LV IY II + +I
Sbjct: 684 TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYI 743
Query: 662 FLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLK 721
LN+ + + VD+ A + L A++E + K L + + + E E + G +
Sbjct: 744 LLNVFLAIAVDNLADA--ESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKE 801
Query: 722 RLIEKK 727
IE K
Sbjct: 802 EKIELK 807
Score = 60.8 bits (146), Expect = 5e-09
Identities = 79/380 (20%), Positives = 147/380 (38%), Gaps = 82/380 (21%)
Query: 380 KVHTQDISTKHSED---------WGKEEGQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLT 430
K++ D+ +ED G+E+ + + G R + H + E
Sbjct: 820 KINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 431 FLI----QGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSI 486
F I FR + F I F + L+++ L A+ + D +
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYV 939
Query: 487 FFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSL 541
F I+ +E +LK+ A G S+ +++N LD +++++++ F + +
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS---------- 989
Query: 542 FRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVL 601
+ V K LR LR +R LR ++ ++ V + ++ +I I+I+ F+F+ +
Sbjct: 990 --AINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIG 1047
Query: 602 RALFRK-----SDPKR----------------------------------FQNIFTTIFT 622
LF+ SD + F N+ +
Sbjct: 1048 VQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMA 1107
Query: 623 LFTLLTLDDW-SLIY--MDSRAQ--GAWY-----IIPILVIYIIIQYFIFLNLVITVLVD 672
LFT+ T + W L+Y +DS + G Y I +IYIII F +N+ + ++
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 673 SFQ---TALFKGLEKAKQER 689
+FQ +K E K +R
Sbjct: 1168 TFQEQGEQEYKNCELDKNQR 1187
Score = 59.7 bits (143), Expect = 1e-08
Identities = 71/277 (25%), Positives = 118/277 (42%), Gaps = 64/277 (23%)
Query: 483 LDSIFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIY 537
++ +F I+ VEA LK+IA GL +Y + WN LDF I+ + + +L Q + A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQA-TKADG 220
Query: 538 HQSLFRILKVF--KSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLF 595
+L F K+LRA R +R LR +S + S+Q V ++ +++ + I +L+ +
Sbjct: 221 ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 280
Query: 596 LFSAVLRALF------------------RKSDPK-------------------------- 611
+++ + LF + DP
Sbjct: 281 IYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPK 340
Query: 612 ----RFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLV 666
F N + T+F +T++ W+ ++Y + A G + V III F LNLV
Sbjct: 341 HGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLV 400
Query: 667 ITVLVDSFQTALFKGLEKAKQE---RAARIQEKLLED 700
+ VL F K EKAK + R +++L ED
Sbjct: 401 LGVLSGEFS----KEREKAKARGDFQKLREKQQLEED 433
Score = 59.3 bits (142), Expect = 1e-08
Identities = 54/269 (20%), Positives = 118/269 (43%), Gaps = 41/269 (15%)
Query: 443 LTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIAL 502
+ S FE +F ++ LNT+ L Q + + + L+ +F ++ VE +LK+IA
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQ-SCLFKIAMNILNMLFTGLFTVEMILKLIAF 1273
Query: 503 GLSYFF-DFWNNLDFFIMAMAVLDFLLMQTH-------SFAIYHQSLFRI-LKVFKSLRA 553
++F D WN D I+ +++D + + + S ++ + RI + F+ R
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333
Query: 554 LRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRK------ 607
+R +++L R + ++ Q+LP +A +++++F F+++ + +F K
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLF---FIYAVIGMQVFGKIALNDT 1390
Query: 608 ---SDPKRFQNIFTTIFTLFTLLTLDDWSLIYM-------------------DSRAQGAW 645
+ FQ + LF T + W I + G+
Sbjct: 1391 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1450
Query: 646 YIIPILVIYIIIQYFIFLNLVITVLVDSF 674
+ + + + ++ F+ +NL + V++D+F
Sbjct: 1451 FAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
>gi|193788728 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 3 [Homo sapiens]
Length = 2179
Score = 89.0 bits (219), Expect = 2e-17
Identities = 79/306 (25%), Positives = 145/306 (47%), Gaps = 27/306 (8%)
Query: 437 REMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEAL 496
R R +S F + F+V LNT+ + ++ + + E A + ++ E L
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA-NKALLALFTAEML 572
Query: 497 LKIIALGL-SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALR 555
LK+ +LGL +YF +N D F++ +L+ +L++T + S+ LR +R
Sbjct: 573 LKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISV---------LRCVR 623
Query: 556 AIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF--------RK 607
+R+ + + S+ + +L S+ SIA++L+L+F + +FS + LF +
Sbjct: 624 LLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQ 683
Query: 608 SDPKRFQNIFTTIFTLFTLLTLDDW-SLIYMDSRAQGAWYIIPILV-IYIIIQY----FI 661
+ F N ++ T+F +LT +DW S++Y A G +LV IY II + +I
Sbjct: 684 TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYI 743
Query: 662 FLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLK 721
LN+ + + VD+ A + L A++E + K L + + + E E + G +
Sbjct: 744 LLNVFLAIAVDNLADA--ESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKE 801
Query: 722 RLIEKK 727
IE K
Sbjct: 802 EKIELK 807
Score = 62.0 bits (149), Expect = 2e-09
Identities = 79/380 (20%), Positives = 146/380 (38%), Gaps = 82/380 (21%)
Query: 380 KVHTQDISTKHSED---------WGKEEGQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLT 430
K++ D+ +ED G+E+ + + G R + H + E
Sbjct: 820 KINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 431 FLI----QGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSI 486
F I FR + F I F + L+++ L A+ + D +
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 487 FFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSL 541
F I+ +E LK+ A G S+ +++N LD +++++++ F + +
Sbjct: 940 FTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS---------- 989
Query: 542 FRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVL 601
+ V K LR LR +R LR ++ ++ V + ++ +I I+I+ F+F+ +
Sbjct: 990 --AINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIG 1047
Query: 602 RALFRK-----SDPKR----------------------------------FQNIFTTIFT 622
LF+ SD + F N+ +
Sbjct: 1048 VQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMA 1107
Query: 623 LFTLLTLDDW-SLIY--MDSRAQ--GAWY-----IIPILVIYIIIQYFIFLNLVITVLVD 672
LFT+ T + W L+Y +DS + G Y I +IYIII F +N+ + ++
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 673 SFQ---TALFKGLEKAKQER 689
+FQ +K E K +R
Sbjct: 1168 TFQEQGEQEYKNCELDKNQR 1187
Score = 59.7 bits (143), Expect = 1e-08
Identities = 71/277 (25%), Positives = 118/277 (42%), Gaps = 64/277 (23%)
Query: 483 LDSIFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIY 537
++ +F I+ VEA LK+IA GL +Y + WN LDF I+ + + +L Q + A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQA-TKADG 220
Query: 538 HQSLFRILKVF--KSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLF 595
+L F K+LRA R +R LR +S + S+Q V ++ +++ + I +L+ +
Sbjct: 221 ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 280
Query: 596 LFSAVLRALF------------------RKSDPK-------------------------- 611
+++ + LF + DP
Sbjct: 281 IYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPK 340
Query: 612 ----RFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLV 666
F N + T+F +T++ W+ ++Y + A G + V III F LNLV
Sbjct: 341 HGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLV 400
Query: 667 ITVLVDSFQTALFKGLEKAKQE---RAARIQEKLLED 700
+ VL F K EKAK + R +++L ED
Sbjct: 401 LGVLSGEFS----KEREKAKARGDFQKLREKQQLEED 433
Score = 50.8 bits (120), Expect = 5e-06
Identities = 52/291 (17%), Positives = 115/291 (39%), Gaps = 63/291 (21%)
Query: 443 LTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIAL 502
+ S FE +F ++ LNT+ L Q + + + L+ +F ++ VE +LK+IA
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQ-SCLFKIAMNILNMLFTGLFTVEMILKLIAF 1273
Query: 503 GLSYFF-DFWNNLDFFIMAMAVLDFLLMQTH----------------------------- 532
++F D WN D I+ +++D + + +
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMGPSCSHPPLAVLTAPPVA 1333
Query: 533 -SFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMF 591
F ++ + F+ R +R +++L R + ++ Q+LP +A +++++F
Sbjct: 1334 DGFQNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLF 1393
Query: 592 TCLFLFSAVLRALFRK---------SDPKRFQNIFTTIFTLFTLLTLDDWSLIYM----- 637
F+++ + +F K + FQ + LF T + W I +
Sbjct: 1394 ---FIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPG 1450
Query: 638 --------------DSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVDSF 674
G+ + + + + ++ F+ +NL + V++D+F
Sbjct: 1451 KKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1501
>gi|193788724 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 2 [Homo sapiens]
Length = 2186
Score = 89.0 bits (219), Expect = 2e-17
Identities = 79/306 (25%), Positives = 145/306 (47%), Gaps = 27/306 (8%)
Query: 437 REMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEAL 496
R R +S F + F+V LNT+ + ++ + + E A + ++ E L
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA-NKALLALFTAEML 572
Query: 497 LKIIALGL-SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALR 555
LK+ +LGL +YF +N D F++ +L+ +L++T + S+ LR +R
Sbjct: 573 LKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISV---------LRCVR 623
Query: 556 AIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF--------RK 607
+R+ + + S+ + +L S+ SIA++L+L+F + +FS + LF +
Sbjct: 624 LLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQ 683
Query: 608 SDPKRFQNIFTTIFTLFTLLTLDDW-SLIYMDSRAQGAWYIIPILV-IYIIIQY----FI 661
+ F N ++ T+F +LT +DW S++Y A G +LV IY II + +I
Sbjct: 684 TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYI 743
Query: 662 FLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLK 721
LN+ + + VD+ A + L A++E + K L + + + E E + G +
Sbjct: 744 LLNVFLAIAVDNLADA--ESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKE 801
Query: 722 RLIEKK 727
IE K
Sbjct: 802 EKIELK 807
Score = 59.7 bits (143), Expect = 1e-08
Identities = 71/277 (25%), Positives = 118/277 (42%), Gaps = 64/277 (23%)
Query: 483 LDSIFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIY 537
++ +F I+ VEA LK+IA GL +Y + WN LDF I+ + + +L Q + A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQA-TKADG 220
Query: 538 HQSLFRILKVF--KSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLF 595
+L F K+LRA R +R LR +S + S+Q V ++ +++ + I +L+ +
Sbjct: 221 ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 280
Query: 596 LFSAVLRALF------------------RKSDPK-------------------------- 611
+++ + LF + DP
Sbjct: 281 IYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPK 340
Query: 612 ----RFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLV 666
F N + T+F +T++ W+ ++Y + A G + V III F LNLV
Sbjct: 341 HGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLV 400
Query: 667 ITVLVDSFQTALFKGLEKAKQE---RAARIQEKLLED 700
+ VL F K EKAK + R +++L ED
Sbjct: 401 LGVLSGEFS----KEREKAKARGDFQKLREKQQLEED 433
Score = 57.0 bits (136), Expect = 7e-08
Identities = 60/297 (20%), Positives = 120/297 (40%), Gaps = 69/297 (23%)
Query: 443 LTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIAL 502
+ S FE +F ++ LNT+ L Q + + + L+ +F ++ VE +LK+IA
Sbjct: 1235 VVNSTYFEYLMFVLILLNTICLAMQHYGQ-SCLFKIAMNILNMLFTGLFTVEMILKLIAF 1293
Query: 503 G-LSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSL---------- 551
YF D WN DF I+ +++D +L +T+ + + F L V S+
Sbjct: 1294 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNP 1353
Query: 552 -----------------------RALRAIRVLRRLSFLTSVQEVTGTL---GQSLPSIAA 585
R R +R+++ LS ++ + T Q+LP +A
Sbjct: 1354 AEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1413
Query: 586 ILILMFTCLFLFSAVLRALFRK---------SDPKRFQNIFTTIFTLFTLLTLDDWSLIY 636
+++++F F+++ + +F K + FQ + LF T + W I
Sbjct: 1414 LIVMLF---FIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIM 1470
Query: 637 M-------------------DSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVDSF 674
+ G+ + + + + ++ F+ +NL + V++D+F
Sbjct: 1471 LACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1527
Score = 54.7 bits (130), Expect = 3e-07
Identities = 81/399 (20%), Positives = 141/399 (35%), Gaps = 100/399 (25%)
Query: 380 KVHTQDISTKHSED---------WGKEEGQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLT 430
K++ D+ +ED G+E+ + + G R + H + E
Sbjct: 820 KINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 431 FLI----QGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSI 486
F I FR + F I F + L+++ L A+ + D +
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 487 FFCIYVVEALLKIIALGLSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLF---- 542
F I+ +E LKI+ N D+ ++ L+ +L T A H+ F
Sbjct: 940 FTTIFTIEIALKILG-----------NADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNY 988
Query: 543 --------------------RILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPS 582
+ V K LR LR +R LR ++ ++ V + ++ +
Sbjct: 989 FNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRT 1048
Query: 583 IAAILILMFTCLFLFSAVLRALFRK-----SDPKR------------------------- 612
I I+I+ F+F+ + LF+ SD +
Sbjct: 1049 IGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQP 1108
Query: 613 ---------FQNIFTTIFTLFTLLTLDDW-SLIY--MDSRAQ--GAWY-----IIPILVI 653
F N+ + LFT+ T + W L+Y +DS + G Y I +I
Sbjct: 1109 RSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFII 1168
Query: 654 YIIIQYFIFLNLVITVLVDSFQ---TALFKGLEKAKQER 689
YIII F +N+ + ++ +FQ +K E K +R
Sbjct: 1169 YIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQR 1207
>gi|193788720 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 1 [Homo sapiens]
Length = 2221
Score = 89.0 bits (219), Expect = 2e-17
Identities = 79/306 (25%), Positives = 145/306 (47%), Gaps = 27/306 (8%)
Query: 437 REMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEAL 496
R R +S F + F+V LNT+ + ++ + + E A + ++ E L
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA-NKALLALFTAEML 572
Query: 497 LKIIALGL-SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALR 555
LK+ +LGL +YF +N D F++ +L+ +L++T + S+ LR +R
Sbjct: 573 LKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISV---------LRCVR 623
Query: 556 AIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF--------RK 607
+R+ + + S+ + +L S+ SIA++L+L+F + +FS + LF +
Sbjct: 624 LLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQ 683
Query: 608 SDPKRFQNIFTTIFTLFTLLTLDDW-SLIYMDSRAQGAWYIIPILV-IYIIIQY----FI 661
+ F N ++ T+F +LT +DW S++Y A G +LV IY II + +I
Sbjct: 684 TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYI 743
Query: 662 FLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLK 721
LN+ + + VD+ A + L A++E + K L + + + E E + G +
Sbjct: 744 LLNVFLAIAVDNLADA--ESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKE 801
Query: 722 RLIEKK 727
IE K
Sbjct: 802 EKIELK 807
Score = 59.7 bits (143), Expect = 1e-08
Identities = 71/277 (25%), Positives = 118/277 (42%), Gaps = 64/277 (23%)
Query: 483 LDSIFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIY 537
++ +F I+ VEA LK+IA GL +Y + WN LDF I+ + + +L Q + A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQA-TKADG 220
Query: 538 HQSLFRILKVF--KSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLF 595
+L F K+LRA R +R LR +S + S+Q V ++ +++ + I +L+ +
Sbjct: 221 ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 280
Query: 596 LFSAVLRALF------------------RKSDPK-------------------------- 611
+++ + LF + DP
Sbjct: 281 IYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPK 340
Query: 612 ----RFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLV 666
F N + T+F +T++ W+ ++Y + A G + V III F LNLV
Sbjct: 341 HGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLV 400
Query: 667 ITVLVDSFQTALFKGLEKAKQE---RAARIQEKLLED 700
+ VL F K EKAK + R +++L ED
Sbjct: 401 LGVLSGEFS----KEREKAKARGDFQKLREKQQLEED 433
Score = 57.0 bits (136), Expect = 7e-08
Identities = 60/297 (20%), Positives = 120/297 (40%), Gaps = 69/297 (23%)
Query: 443 LTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIAL 502
+ S FE +F ++ LNT+ L Q + + + L+ +F ++ VE +LK+IA
Sbjct: 1235 VVNSTYFEYLMFVLILLNTICLAMQHYGQ-SCLFKIAMNILNMLFTGLFTVEMILKLIAF 1293
Query: 503 G-LSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSL---------- 551
YF D WN DF I+ +++D +L +T+ + + F L V S+
Sbjct: 1294 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNP 1353
Query: 552 -----------------------RALRAIRVLRRLSFLTSVQEVTGTL---GQSLPSIAA 585
R R +R+++ LS ++ + T Q+LP +A
Sbjct: 1354 AEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVAL 1413
Query: 586 ILILMFTCLFLFSAVLRALFRK---------SDPKRFQNIFTTIFTLFTLLTLDDWSLIY 636
+++++F F+++ + +F K + FQ + LF T + W I
Sbjct: 1414 LIVMLF---FIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIM 1470
Query: 637 M-------------------DSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVDSF 674
+ G+ + + + + ++ F+ +NL + V++D+F
Sbjct: 1471 LACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1527
Score = 54.7 bits (130), Expect = 3e-07
Identities = 81/399 (20%), Positives = 141/399 (35%), Gaps = 100/399 (25%)
Query: 380 KVHTQDISTKHSED---------WGKEEGQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLT 430
K++ D+ +ED G+E+ + + G R + H + E
Sbjct: 820 KINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 431 FLI----QGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSI 486
F I FR + F I F + L+++ L A+ + D +
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 487 FFCIYVVEALLKIIALGLSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLF---- 542
F I+ +E LKI+ N D+ ++ L+ +L T A H+ F
Sbjct: 940 FTTIFTIEIALKILG-----------NADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNY 988
Query: 543 --------------------RILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPS 582
+ V K LR LR +R LR ++ ++ V + ++ +
Sbjct: 989 FNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRT 1048
Query: 583 IAAILILMFTCLFLFSAVLRALFRK-----SDPKR------------------------- 612
I I+I+ F+F+ + LF+ SD +
Sbjct: 1049 IGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQP 1108
Query: 613 ---------FQNIFTTIFTLFTLLTLDDW-SLIY--MDSRAQ--GAWY-----IIPILVI 653
F N+ + LFT+ T + W L+Y +DS + G Y I +I
Sbjct: 1109 RSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFII 1168
Query: 654 YIIIQYFIFLNLVITVLVDSFQ---TALFKGLEKAKQER 689
YIII F +N+ + ++ +FQ +K E K +R
Sbjct: 1169 YIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQR 1207
>gi|120433602 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 18 [Homo sapiens]
Length = 2138
Score = 89.0 bits (219), Expect = 2e-17
Identities = 79/306 (25%), Positives = 145/306 (47%), Gaps = 27/306 (8%)
Query: 437 REMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEAL 496
R R +S F + F+V LNT+ + ++ + + E A + ++ E L
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA-NKALLALFTAEML 572
Query: 497 LKIIALGL-SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALR 555
LK+ +LGL +YF +N D F++ +L+ +L++T + S+ LR +R
Sbjct: 573 LKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISV---------LRCVR 623
Query: 556 AIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF--------RK 607
+R+ + + S+ + +L S+ SIA++L+L+F + +FS + LF +
Sbjct: 624 LLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQ 683
Query: 608 SDPKRFQNIFTTIFTLFTLLTLDDW-SLIYMDSRAQGAWYIIPILV-IYIIIQY----FI 661
+ F N ++ T+F +LT +DW S++Y A G +LV IY II + +I
Sbjct: 684 TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYI 743
Query: 662 FLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLK 721
LN+ + + VD+ A + L A++E + K L + + + E E + G +
Sbjct: 744 LLNVFLAIAVDNLADA--ESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKE 801
Query: 722 RLIEKK 727
IE K
Sbjct: 802 EKIELK 807
Score = 62.0 bits (149), Expect = 2e-09
Identities = 79/380 (20%), Positives = 146/380 (38%), Gaps = 82/380 (21%)
Query: 380 KVHTQDISTKHSED---------WGKEEGQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLT 430
K++ D+ +ED G+E+ + + G R + H + E
Sbjct: 820 KINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 431 FLI----QGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSI 486
F I FR + F I F + L+++ L A+ + D +
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 487 FFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSL 541
F I+ +E LK+ A G S+ +++N LD +++++++ F + +
Sbjct: 940 FTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS---------- 989
Query: 542 FRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVL 601
+ V K LR LR +R LR ++ ++ V + ++ +I I+I+ F+F+ +
Sbjct: 990 --AINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIG 1047
Query: 602 RALFRK-----SDPKR----------------------------------FQNIFTTIFT 622
LF+ SD + F N+ +
Sbjct: 1048 VQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMA 1107
Query: 623 LFTLLTLDDW-SLIY--MDSRAQ--GAWY-----IIPILVIYIIIQYFIFLNLVITVLVD 672
LFT+ T + W L+Y +DS + G Y I +IYIII F +N+ + ++
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 673 SFQ---TALFKGLEKAKQER 689
+FQ +K E K +R
Sbjct: 1168 TFQEQGEQEYKNCELDKNQR 1187
Score = 59.7 bits (143), Expect = 1e-08
Identities = 71/277 (25%), Positives = 118/277 (42%), Gaps = 64/277 (23%)
Query: 483 LDSIFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIY 537
++ +F I+ VEA LK+IA GL +Y + WN LDF I+ + + +L Q + A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQA-TKADG 220
Query: 538 HQSLFRILKVF--KSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLF 595
+L F K+LRA R +R LR +S + S+Q V ++ +++ + I +L+ +
Sbjct: 221 ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 280
Query: 596 LFSAVLRALF------------------RKSDPK-------------------------- 611
+++ + LF + DP
Sbjct: 281 IYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPK 340
Query: 612 ----RFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLV 666
F N + T+F +T++ W+ ++Y + A G + V III F LNLV
Sbjct: 341 HGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLV 400
Query: 667 ITVLVDSFQTALFKGLEKAKQE---RAARIQEKLLED 700
+ VL F K EKAK + R +++L ED
Sbjct: 401 LGVLSGEFS----KEREKAKARGDFQKLREKQQLEED 433
Score = 59.3 bits (142), Expect = 1e-08
Identities = 54/269 (20%), Positives = 118/269 (43%), Gaps = 41/269 (15%)
Query: 443 LTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIAL 502
+ S FE +F ++ LNT+ L Q + + + L+ +F ++ VE +LK+IA
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQ-SCLFKIAMNILNMLFTGLFTVEMILKLIAF 1273
Query: 503 GLSYFF-DFWNNLDFFIMAMAVLDFLLMQTH-------SFAIYHQSLFRI-LKVFKSLRA 553
++F D WN D I+ +++D + + + S ++ + RI + F+ R
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333
Query: 554 LRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRK------ 607
+R +++L R + ++ Q+LP +A +++++F F+++ + +F K
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLF---FIYAVIGMQVFGKIALNDT 1390
Query: 608 ---SDPKRFQNIFTTIFTLFTLLTLDDWSLIYM-------------------DSRAQGAW 645
+ FQ + LF T + W I + G+
Sbjct: 1391 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1450
Query: 646 YIIPILVIYIIIQYFIFLNLVITVLVDSF 674
+ + + + ++ F+ +NL + V++D+F
Sbjct: 1451 FAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
>gi|193788548 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 20 [Homo sapiens]
Length = 2127
Score = 89.0 bits (219), Expect = 2e-17
Identities = 79/306 (25%), Positives = 145/306 (47%), Gaps = 27/306 (8%)
Query: 437 REMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEAL 496
R R +S F + F+V LNT+ + ++ + + E A + ++ E L
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA-NKALLALFTAEML 572
Query: 497 LKIIALGL-SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALR 555
LK+ +LGL +YF +N D F++ +L+ +L++T + S+ LR +R
Sbjct: 573 LKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISV---------LRCVR 623
Query: 556 AIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF--------RK 607
+R+ + + S+ + +L S+ SIA++L+L+F + +FS + LF +
Sbjct: 624 LLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQ 683
Query: 608 SDPKRFQNIFTTIFTLFTLLTLDDW-SLIYMDSRAQGAWYIIPILV-IYIIIQY----FI 661
+ F N ++ T+F +LT +DW S++Y A G +LV IY II + +I
Sbjct: 684 TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYI 743
Query: 662 FLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLK 721
LN+ + + VD+ A + L A++E + K L + + + E E + G +
Sbjct: 744 LLNVFLAIAVDNLADA--ESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKE 801
Query: 722 RLIEKK 727
IE K
Sbjct: 802 EKIELK 807
Score = 63.2 bits (152), Expect = 9e-10
Identities = 57/267 (21%), Positives = 117/267 (43%), Gaps = 48/267 (17%)
Query: 443 LTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIAL 502
+ S FE +F ++ LNT+ L Q + + + L+ +F ++ VE +LK+IA
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQ-SCLFKIAMNILNMLFTGLFTVEMILKLIAF 1273
Query: 503 GLSYFF-DFWNNLDFFIMAMAVLDFLLMQTHS------FAIYHQSLFRILKVFKSLRALR 555
++F D WN D I+ +++D + + ++ +I LFR++++ K L
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGE 1333
Query: 556 AIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRK-------- 607
IR L +F+ S Q+LP +A +++++F F+++ + +F K
Sbjct: 1334 GIRTL-LWTFIKSF--------QALPYVALLIVMLF---FIYAVIGMQVFGKIALNDTTE 1381
Query: 608 -SDPKRFQNIFTTIFTLFTLLTLDDWSLIYM-------------------DSRAQGAWYI 647
+ FQ + LF T + W I + G+ +
Sbjct: 1382 INRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFA 1441
Query: 648 IPILVIYIIIQYFIFLNLVITVLVDSF 674
+ + + ++ F+ +NL + V++D+F
Sbjct: 1442 VFYFISFYMLCAFLIINLFVAVIMDNF 1468
Score = 60.8 bits (146), Expect = 5e-09
Identities = 79/380 (20%), Positives = 147/380 (38%), Gaps = 82/380 (21%)
Query: 380 KVHTQDISTKHSED---------WGKEEGQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLT 430
K++ D+ +ED G+E+ + + G R + H + E
Sbjct: 820 KINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 431 FLI----QGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSI 486
F I FR + F I F + L+++ L A+ + D +
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYV 939
Query: 487 FFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSL 541
F I+ +E +LK+ A G S+ +++N LD +++++++ F + +
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS---------- 989
Query: 542 FRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVL 601
+ V K LR LR +R LR ++ ++ V + ++ +I I+I+ F+F+ +
Sbjct: 990 --AINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIG 1047
Query: 602 RALFRK-----SDPKR----------------------------------FQNIFTTIFT 622
LF+ SD + F N+ +
Sbjct: 1048 VQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMA 1107
Query: 623 LFTLLTLDDW-SLIY--MDSRAQ--GAWY-----IIPILVIYIIIQYFIFLNLVITVLVD 672
LFT+ T + W L+Y +DS + G Y I +IYIII F +N+ + ++
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 673 SFQ---TALFKGLEKAKQER 689
+FQ +K E K +R
Sbjct: 1168 TFQEQGEQEYKNCELDKNQR 1187
Score = 59.7 bits (143), Expect = 1e-08
Identities = 71/277 (25%), Positives = 118/277 (42%), Gaps = 64/277 (23%)
Query: 483 LDSIFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIY 537
++ +F I+ VEA LK+IA GL +Y + WN LDF I+ + + +L Q + A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQA-TKADG 220
Query: 538 HQSLFRILKVF--KSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLF 595
+L F K+LRA R +R LR +S + S+Q V ++ +++ + I +L+ +
Sbjct: 221 ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 280
Query: 596 LFSAVLRALF------------------RKSDPK-------------------------- 611
+++ + LF + DP
Sbjct: 281 IYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPK 340
Query: 612 ----RFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLV 666
F N + T+F +T++ W+ ++Y + A G + V III F LNLV
Sbjct: 341 HGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLV 400
Query: 667 ITVLVDSFQTALFKGLEKAKQE---RAARIQEKLLED 700
+ VL F K EKAK + R +++L ED
Sbjct: 401 LGVLSGEFS----KEREKAKARGDFQKLREKQQLEED 433
>gi|193788544 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 19 [Homo sapiens]
Length = 2135
Score = 89.0 bits (219), Expect = 2e-17
Identities = 79/306 (25%), Positives = 145/306 (47%), Gaps = 27/306 (8%)
Query: 437 REMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEAL 496
R R +S F + F+V LNT+ + ++ + + E A + ++ E L
Sbjct: 511 RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA-NKALLALFTAEML 569
Query: 497 LKIIALGL-SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALR 555
LK+ +LGL +YF +N D F++ +L+ +L++T + S+ LR +R
Sbjct: 570 LKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISV---------LRCVR 620
Query: 556 AIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF--------RK 607
+R+ + + S+ + +L S+ SIA++L+L+F + +FS + LF +
Sbjct: 621 LLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQ 680
Query: 608 SDPKRFQNIFTTIFTLFTLLTLDDW-SLIYMDSRAQGAWYIIPILV-IYIIIQY----FI 661
+ F N ++ T+F +LT +DW S++Y A G +LV IY II + +I
Sbjct: 681 TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYI 740
Query: 662 FLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLK 721
LN+ + + VD+ A + L A++E + K L + + + E E + G +
Sbjct: 741 LLNVFLAIAVDNLADA--ESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKE 798
Query: 722 RLIEKK 727
IE K
Sbjct: 799 EKIELK 804
Score = 64.3 bits (155), Expect = 4e-10
Identities = 58/269 (21%), Positives = 120/269 (44%), Gaps = 41/269 (15%)
Query: 443 LTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIAL 502
+ S FE +F ++ LNT+ L Q + + + L+ +F ++ VE +LK+IA
Sbjct: 1212 VVNSTYFEYLMFVLILLNTICLAMQHYGQ-SCLFKIAMNILNMLFTGLFTVEMILKLIAF 1270
Query: 503 G-LSYFFDFWNNLDFFIMAMAVLDFLLMQTH-------SFAIYHQSLFRI-LKVFKSLRA 553
YF D WN DF I+ +++D +L +T+ S ++ + RI + F+ R
Sbjct: 1271 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRV 1330
Query: 554 LRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRK------ 607
+R +++L R + ++ Q+LP +A +++++F F+++ + +F K
Sbjct: 1331 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLF---FIYAVIGMQVFGKIALNDT 1387
Query: 608 ---SDPKRFQNIFTTIFTLFTLLTLDDWSLIYM-------------------DSRAQGAW 645
+ FQ + LF T + W I + G+
Sbjct: 1388 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1447
Query: 646 YIIPILVIYIIIQYFIFLNLVITVLVDSF 674
+ + + + ++ F+ +NL + V++D+F
Sbjct: 1448 FAVFYFISFYMLCAFLIINLFVAVIMDNF 1476
Score = 62.0 bits (149), Expect = 2e-09
Identities = 79/380 (20%), Positives = 146/380 (38%), Gaps = 82/380 (21%)
Query: 380 KVHTQDISTKHSED---------WGKEEGQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLT 430
K++ D+ +ED G+E+ + + G R + H + E
Sbjct: 817 KINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 876
Query: 431 FLI----QGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSI 486
F I FR + F I F + L+++ L A+ + D +
Sbjct: 877 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 936
Query: 487 FFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSL 541
F I+ +E LK+ A G S+ +++N LD +++++++ F + +
Sbjct: 937 FTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS---------- 986
Query: 542 FRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVL 601
+ V K LR LR +R LR ++ ++ V + ++ +I I+I+ F+F+ +
Sbjct: 987 --AINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIG 1044
Query: 602 RALFRK-----SDPKR----------------------------------FQNIFTTIFT 622
LF+ SD + F N+ +
Sbjct: 1045 VQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMA 1104
Query: 623 LFTLLTLDDW-SLIY--MDSRAQ--GAWY-----IIPILVIYIIIQYFIFLNLVITVLVD 672
LFT+ T + W L+Y +DS + G Y I +IYIII F +N+ + ++
Sbjct: 1105 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1164
Query: 673 SFQ---TALFKGLEKAKQER 689
+FQ +K E K +R
Sbjct: 1165 TFQEQGEQEYKNCELDKNQR 1184
Score = 60.8 bits (146), Expect = 5e-09
Identities = 71/274 (25%), Positives = 118/274 (43%), Gaps = 61/274 (22%)
Query: 483 LDSIFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIY 537
++ +F I+ VEA LK+IA GL +Y + WN LDF I+ + + +L Q + A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQA-TKADG 220
Query: 538 HQSLFRILKVF--KSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLF 595
+L F K+LRA R +R LR +S + S+Q V ++ +++ + I +L+ +
Sbjct: 221 ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 280
Query: 596 LFSAVLRALF---------------RKSDPK----------------------------- 611
+++ + LF + DP
Sbjct: 281 IYAIIGLELFMGKMHKTCYNQEGIAAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGI 340
Query: 612 -RFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLVITV 669
F N + T+F +T++ W+ ++Y + A G + V III F LNLV+ V
Sbjct: 341 TNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGV 400
Query: 670 LVDSFQTALFKGLEKAKQE---RAARIQEKLLED 700
L F K EKAK + R +++L ED
Sbjct: 401 LSGEFS----KEREKAKARGDFQKLREKQQLEED 430
>gi|193788542 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 17 [Homo sapiens]
Length = 2138
Score = 89.0 bits (219), Expect = 2e-17
Identities = 79/306 (25%), Positives = 145/306 (47%), Gaps = 27/306 (8%)
Query: 437 REMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEAL 496
R R +S F + F+V LNT+ + ++ + + E A + ++ E L
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA-NKALLALFTAEML 572
Query: 497 LKIIALGL-SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALR 555
LK+ +LGL +YF +N D F++ +L+ +L++T + S+ LR +R
Sbjct: 573 LKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISV---------LRCVR 623
Query: 556 AIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF--------RK 607
+R+ + + S+ + +L S+ SIA++L+L+F + +FS + LF +
Sbjct: 624 LLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQ 683
Query: 608 SDPKRFQNIFTTIFTLFTLLTLDDW-SLIYMDSRAQGAWYIIPILV-IYIIIQY----FI 661
+ F N ++ T+F +LT +DW S++Y A G +LV IY II + +I
Sbjct: 684 TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYI 743
Query: 662 FLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLK 721
LN+ + + VD+ A + L A++E + K L + + + E E + G +
Sbjct: 744 LLNVFLAIAVDNLADA--ESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKE 801
Query: 722 RLIEKK 727
IE K
Sbjct: 802 EKIELK 807
Score = 60.8 bits (146), Expect = 5e-09
Identities = 79/380 (20%), Positives = 147/380 (38%), Gaps = 82/380 (21%)
Query: 380 KVHTQDISTKHSED---------WGKEEGQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLT 430
K++ D+ +ED G+E+ + + G R + H + E
Sbjct: 820 KINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 431 FLI----QGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSI 486
F I FR + F I F + L+++ L A+ + D +
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYV 939
Query: 487 FFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSL 541
F I+ +E +LK+ A G S+ +++N LD +++++++ F + +
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS---------- 989
Query: 542 FRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVL 601
+ V K LR LR +R LR ++ ++ V + ++ +I I+I+ F+F+ +
Sbjct: 990 --AINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIG 1047
Query: 602 RALFRK-----SDPKR----------------------------------FQNIFTTIFT 622
LF+ SD + F N+ +
Sbjct: 1048 VQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMA 1107
Query: 623 LFTLLTLDDW-SLIY--MDSRAQ--GAWY-----IIPILVIYIIIQYFIFLNLVITVLVD 672
LFT+ T + W L+Y +DS + G Y I +IYIII F +N+ + ++
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 673 SFQ---TALFKGLEKAKQER 689
+FQ +K E K +R
Sbjct: 1168 TFQEQGEQEYKNCELDKNQR 1187
Score = 59.7 bits (143), Expect = 1e-08
Identities = 71/277 (25%), Positives = 118/277 (42%), Gaps = 64/277 (23%)
Query: 483 LDSIFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIY 537
++ +F I+ VEA LK+IA GL +Y + WN LDF I+ + + +L Q + A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQA-TKADG 220
Query: 538 HQSLFRILKVF--KSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLF 595
+L F K+LRA R +R LR +S + S+Q V ++ +++ + I +L+ +
Sbjct: 221 ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 280
Query: 596 LFSAVLRALF------------------RKSDPK-------------------------- 611
+++ + LF + DP
Sbjct: 281 IYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPK 340
Query: 612 ----RFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLV 666
F N + T+F +T++ W+ ++Y + A G + V III F LNLV
Sbjct: 341 HGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLV 400
Query: 667 ITVLVDSFQTALFKGLEKAKQE---RAARIQEKLLED 700
+ VL F K EKAK + R +++L ED
Sbjct: 401 LGVLSGEFS----KEREKAKARGDFQKLREKQQLEED 433
Score = 59.3 bits (142), Expect = 1e-08
Identities = 54/269 (20%), Positives = 118/269 (43%), Gaps = 41/269 (15%)
Query: 443 LTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIAL 502
+ S FE +F ++ LNT+ L Q + + + L+ +F ++ VE +LK+IA
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQ-SCLFKIAMNILNMLFTGLFTVEMILKLIAF 1273
Query: 503 GLSYFF-DFWNNLDFFIMAMAVLDFLLMQTH-------SFAIYHQSLFRI-LKVFKSLRA 553
++F D WN D I+ +++D + + + S ++ + RI + F+ R
Sbjct: 1274 KPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333
Query: 554 LRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRK------ 607
+R +++L R + ++ Q+LP +A +++++F F+++ + +F K
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLF---FIYAVIGMQVFGKIALNDT 1390
Query: 608 ---SDPKRFQNIFTTIFTLFTLLTLDDWSLIYM-------------------DSRAQGAW 645
+ FQ + LF T + W I + G+
Sbjct: 1391 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1450
Query: 646 YIIPILVIYIIIQYFIFLNLVITVLVDSF 674
+ + + + ++ F+ +NL + V++D+F
Sbjct: 1451 FAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
>gi|193788540 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 16 [Homo sapiens]
Length = 2138
Score = 89.0 bits (219), Expect = 2e-17
Identities = 79/306 (25%), Positives = 145/306 (47%), Gaps = 27/306 (8%)
Query: 437 REMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEAL 496
R R +S F + F+V LNT+ + ++ + + E A + ++ E L
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA-NKALLALFTAEML 572
Query: 497 LKIIALGL-SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALR 555
LK+ +LGL +YF +N D F++ +L+ +L++T + S+ LR +R
Sbjct: 573 LKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISV---------LRCVR 623
Query: 556 AIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF--------RK 607
+R+ + + S+ + +L S+ SIA++L+L+F + +FS + LF +
Sbjct: 624 LLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQ 683
Query: 608 SDPKRFQNIFTTIFTLFTLLTLDDW-SLIYMDSRAQGAWYIIPILV-IYIIIQY----FI 661
+ F N ++ T+F +LT +DW S++Y A G +LV IY II + +I
Sbjct: 684 TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYI 743
Query: 662 FLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLK 721
LN+ + + VD+ A + L A++E + K L + + + E E + G +
Sbjct: 744 LLNVFLAIAVDNLADA--ESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKE 801
Query: 722 RLIEKK 727
IE K
Sbjct: 802 EKIELK 807
Score = 64.3 bits (155), Expect = 4e-10
Identities = 58/269 (21%), Positives = 120/269 (44%), Gaps = 41/269 (15%)
Query: 443 LTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIAL 502
+ S FE +F ++ LNT+ L Q + + + L+ +F ++ VE +LK+IA
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQ-SCLFKIAMNILNMLFTGLFTVEMILKLIAF 1273
Query: 503 G-LSYFFDFWNNLDFFIMAMAVLDFLLMQTH-------SFAIYHQSLFRI-LKVFKSLRA 553
YF D WN DF I+ +++D +L +T+ S ++ + RI + F+ R
Sbjct: 1274 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333
Query: 554 LRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRK------ 607
+R +++L R + ++ Q+LP +A +++++F F+++ + +F K
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLF---FIYAVIGMQVFGKIALNDT 1390
Query: 608 ---SDPKRFQNIFTTIFTLFTLLTLDDWSLIYM-------------------DSRAQGAW 645
+ FQ + LF T + W I + G+
Sbjct: 1391 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1450
Query: 646 YIIPILVIYIIIQYFIFLNLVITVLVDSF 674
+ + + + ++ F+ +NL + V++D+F
Sbjct: 1451 FAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
Score = 62.0 bits (149), Expect = 2e-09
Identities = 79/380 (20%), Positives = 146/380 (38%), Gaps = 82/380 (21%)
Query: 380 KVHTQDISTKHSED---------WGKEEGQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLT 430
K++ D+ +ED G+E+ + + G R + H + E
Sbjct: 820 KINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 431 FLI----QGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSI 486
F I FR + F I F + L+++ L A+ + D +
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIV 939
Query: 487 FFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSL 541
F I+ +E LK+ A G S+ +++N LD +++++++ F + +
Sbjct: 940 FTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS---------- 989
Query: 542 FRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVL 601
+ V K LR LR +R LR ++ ++ V + ++ +I I+I+ F+F+ +
Sbjct: 990 --AINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIG 1047
Query: 602 RALFRK-----SDPKR----------------------------------FQNIFTTIFT 622
LF+ SD + F N+ +
Sbjct: 1048 VQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMA 1107
Query: 623 LFTLLTLDDW-SLIY--MDSRAQ--GAWY-----IIPILVIYIIIQYFIFLNLVITVLVD 672
LFT+ T + W L+Y +DS + G Y I +IYIII F +N+ + ++
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 673 SFQ---TALFKGLEKAKQER 689
+FQ +K E K +R
Sbjct: 1168 TFQEQGEQEYKNCELDKNQR 1187
Score = 59.7 bits (143), Expect = 1e-08
Identities = 71/277 (25%), Positives = 118/277 (42%), Gaps = 64/277 (23%)
Query: 483 LDSIFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIY 537
++ +F I+ VEA LK+IA GL +Y + WN LDF I+ + + +L Q + A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQA-TKADG 220
Query: 538 HQSLFRILKVF--KSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLF 595
+L F K+LRA R +R LR +S + S+Q V ++ +++ + I +L+ +
Sbjct: 221 ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 280
Query: 596 LFSAVLRALF------------------RKSDPK-------------------------- 611
+++ + LF + DP
Sbjct: 281 IYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPK 340
Query: 612 ----RFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLV 666
F N + T+F +T++ W+ ++Y + A G + V III F LNLV
Sbjct: 341 HGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLV 400
Query: 667 ITVLVDSFQTALFKGLEKAKQE---RAARIQEKLLED 700
+ VL F K EKAK + R +++L ED
Sbjct: 401 LGVLSGEFS----KEREKAKARGDFQKLREKQQLEED 433
>gi|193788538 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 15 [Homo sapiens]
Length = 2138
Score = 89.0 bits (219), Expect = 2e-17
Identities = 79/306 (25%), Positives = 145/306 (47%), Gaps = 27/306 (8%)
Query: 437 REMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEAL 496
R R +S F + F+V LNT+ + ++ + + E A + ++ E L
Sbjct: 514 RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA-NKALLALFTAEML 572
Query: 497 LKIIALGL-SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALR 555
LK+ +LGL +YF +N D F++ +L+ +L++T + S+ LR +R
Sbjct: 573 LKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISV---------LRCVR 623
Query: 556 AIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF--------RK 607
+R+ + + S+ + +L S+ SIA++L+L+F + +FS + LF +
Sbjct: 624 LLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQ 683
Query: 608 SDPKRFQNIFTTIFTLFTLLTLDDW-SLIYMDSRAQGAWYIIPILV-IYIIIQY----FI 661
+ F N ++ T+F +LT +DW S++Y A G +LV IY II + +I
Sbjct: 684 TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYI 743
Query: 662 FLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLK 721
LN+ + + VD+ A + L A++E + K L + + + E E + G +
Sbjct: 744 LLNVFLAIAVDNLADA--ESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKE 801
Query: 722 RLIEKK 727
IE K
Sbjct: 802 EKIELK 807
Score = 64.3 bits (155), Expect = 4e-10
Identities = 58/269 (21%), Positives = 120/269 (44%), Gaps = 41/269 (15%)
Query: 443 LTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIAL 502
+ S FE +F ++ LNT+ L Q + + + L+ +F ++ VE +LK+IA
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQ-SCLFKIAMNILNMLFTGLFTVEMILKLIAF 1273
Query: 503 G-LSYFFDFWNNLDFFIMAMAVLDFLLMQTH-------SFAIYHQSLFRI-LKVFKSLRA 553
YF D WN DF I+ +++D +L +T+ S ++ + RI + F+ R
Sbjct: 1274 KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRV 1333
Query: 554 LRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRK------ 607
+R +++L R + ++ Q+LP +A +++++F F+++ + +F K
Sbjct: 1334 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLF---FIYAVIGMQVFGKIALNDT 1390
Query: 608 ---SDPKRFQNIFTTIFTLFTLLTLDDWSLIYM-------------------DSRAQGAW 645
+ FQ + LF T + W I + G+
Sbjct: 1391 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1450
Query: 646 YIIPILVIYIIIQYFIFLNLVITVLVDSF 674
+ + + + ++ F+ +NL + V++D+F
Sbjct: 1451 FAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
Score = 60.8 bits (146), Expect = 5e-09
Identities = 79/380 (20%), Positives = 147/380 (38%), Gaps = 82/380 (21%)
Query: 380 KVHTQDISTKHSED---------WGKEEGQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLT 430
K++ D+ +ED G+E+ + + G R + H + E
Sbjct: 820 KINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 879
Query: 431 FLI----QGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSI 486
F I FR + F I F + L+++ L A+ + D +
Sbjct: 880 FFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYV 939
Query: 487 FFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSL 541
F I+ +E +LK+ A G S+ +++N LD +++++++ F + +
Sbjct: 940 FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS---------- 989
Query: 542 FRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVL 601
+ V K LR LR +R LR ++ ++ V + ++ +I I+I+ F+F+ +
Sbjct: 990 --AINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIG 1047
Query: 602 RALFRK-----SDPKR----------------------------------FQNIFTTIFT 622
LF+ SD + F N+ +
Sbjct: 1048 VQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMA 1107
Query: 623 LFTLLTLDDW-SLIY--MDSRAQ--GAWY-----IIPILVIYIIIQYFIFLNLVITVLVD 672
LFT+ T + W L+Y +DS + G Y I +IYIII F +N+ + ++
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 673 SFQ---TALFKGLEKAKQER 689
+FQ +K E K +R
Sbjct: 1168 TFQEQGEQEYKNCELDKNQR 1187
Score = 59.7 bits (143), Expect = 1e-08
Identities = 71/277 (25%), Positives = 118/277 (42%), Gaps = 64/277 (23%)
Query: 483 LDSIFFCIYVVEALLKIIALGL-----SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIY 537
++ +F I+ VEA LK+IA GL +Y + WN LDF I+ + + +L Q + A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQA-TKADG 220
Query: 538 HQSLFRILKVF--KSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLF 595
+L F K+LRA R +R LR +S + S+Q V ++ +++ + I +L+ +
Sbjct: 221 ANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVII 280
Query: 596 LFSAVLRALF------------------RKSDPK-------------------------- 611
+++ + LF + DP
Sbjct: 281 IYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPK 340
Query: 612 ----RFQNIFTTIFTLFTLLTLDDWS-LIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLV 666
F N + T+F +T++ W+ ++Y + A G + V III F LNLV
Sbjct: 341 HGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLV 400
Query: 667 ITVLVDSFQTALFKGLEKAKQE---RAARIQEKLLED 700
+ VL F K EKAK + R +++L ED
Sbjct: 401 LGVLSGEFS----KEREKAKARGDFQKLREKQQLEED 433
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.134 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,381,361
Number of Sequences: 37866
Number of extensions: 1617633
Number of successful extensions: 12548
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 154
Number of HSP's successfully gapped in prelim test: 204
Number of HSP's that attempted gapping in prelim test: 6511
Number of HSP's gapped (non-prelim): 2946
length of query: 780
length of database: 18,247,518
effective HSP length: 110
effective length of query: 670
effective length of database: 14,082,258
effective search space: 9435112860
effective search space used: 9435112860
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.