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Search of human proteins with 219555704
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|219555704 leucine rich repeat containing 27 isoform c [Homo
sapiens]
(383 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|219555704 leucine rich repeat containing 27 isoform c [Homo s... 771 0.0
gi|219555702 leucine rich repeat containing 27 isoform b [Homo s... 619 e-177
gi|219555700 leucine rich repeat containing 27 isoform a [Homo s... 619 e-177
gi|55741567 leucine rich repeat containing 27 isoform a [Homo sa... 619 e-177
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 70 4e-12
gi|53729363 leucine rich repeat and sterile alpha motif containi... 69 9e-12
gi|53729361 leucine rich repeat and sterile alpha motif containi... 69 9e-12
gi|53729359 leucine rich repeat and sterile alpha motif containi... 69 9e-12
gi|28872863 CCR4-NOT transcription complex, subunit 6 [Homo sapi... 59 7e-09
gi|115583679 CCR4-NOT transcription complex, subunit 6-like [Hom... 59 7e-09
gi|167466264 leucine rich repeat containing 18 [Homo sapiens] 57 4e-08
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 57 4e-08
gi|61742786 leucine rich repeat and death domain containing prot... 55 8e-08
gi|61742784 leucine rich repeat and death domain containing prot... 55 8e-08
gi|33285015 leucine rich repeat containing 28 [Homo sapiens] 55 8e-08
gi|4503743 flightless I homolog [Homo sapiens] 54 3e-07
gi|197333692 leucine rich repeat containing 8 family, member B [... 54 3e-07
gi|21245134 leucine rich repeat containing 8 family, member B [H... 54 3e-07
gi|62241040 leucine rich repeat containing 8 family, member A [H... 53 4e-07
gi|187829877 leucine rich repeat containing 8 family, member A [... 53 4e-07
gi|187829871 leucine rich repeat containing 8 family, member A [... 53 4e-07
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 53 4e-07
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 52 7e-07
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 52 7e-07
gi|193788651 leucine rich repeat containing 69 [Homo sapiens] 52 7e-07
gi|61742782 leucine rich repeat and death domain containing prot... 52 9e-07
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 52 9e-07
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 52 9e-07
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 51 2e-06
gi|40254924 leucine rich repeat containing 59 [Homo sapiens] 50 3e-06
>gi|219555704 leucine rich repeat containing 27 isoform c [Homo
sapiens]
Length = 383
Score = 771 bits (1990), Expect = 0.0
Identities = 383/383 (100%), Positives = 383/383 (100%)
Query: 1 MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRL 60
MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRL
Sbjct: 1 MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRL 60
Query: 61 EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL
Sbjct: 61 EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
Query: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRN 180
LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRN
Sbjct: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRN 180
Query: 181 PTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDL 240
PTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDL
Sbjct: 181 PTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDL 240
Query: 241 SELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKE 300
SELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKE
Sbjct: 241 SELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKE 300
Query: 301 LPKPRHVFRTRVPRKQALQRLHERKTRIMGVVGRAPTHMGEGRQPPPGASYPTSCHRTKW 360
LPKPRHVFRTRVPRKQALQRLHERKTRIMGVVGRAPTHMGEGRQPPPGASYPTSCHRTKW
Sbjct: 301 LPKPRHVFRTRVPRKQALQRLHERKTRIMGVVGRAPTHMGEGRQPPPGASYPTSCHRTKW 360
Query: 361 RSEQKDWKRAERRRSESSRRSRL 383
RSEQKDWKRAERRRSESSRRSRL
Sbjct: 361 RSEQKDWKRAERRRSESSRRSRL 383
>gi|219555702 leucine rich repeat containing 27 isoform b [Homo
sapiens]
Length = 383
Score = 619 bits (1596), Expect = e-177
Identities = 309/318 (97%), Positives = 313/318 (98%)
Query: 1 MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRL 60
MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRL
Sbjct: 1 MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRL 60
Query: 61 EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL
Sbjct: 61 EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
Query: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRN 180
LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRN
Sbjct: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRN 180
Query: 181 PTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDL 240
PTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDL
Sbjct: 181 PTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDL 240
Query: 241 SELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKE 300
SELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKE
Sbjct: 241 SELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKE 300
Query: 301 LPKPRHVFRTRVPRKQAL 318
LPKPRHVFR + +++
Sbjct: 301 LPKPRHVFRRKTASSRSI 318
>gi|219555700 leucine rich repeat containing 27 isoform a [Homo
sapiens]
Length = 530
Score = 619 bits (1596), Expect = e-177
Identities = 309/318 (97%), Positives = 313/318 (98%)
Query: 1 MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRL 60
MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRL
Sbjct: 1 MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRL 60
Query: 61 EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL
Sbjct: 61 EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
Query: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRN 180
LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRN
Sbjct: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRN 180
Query: 181 PTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDL 240
PTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDL
Sbjct: 181 PTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDL 240
Query: 241 SELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKE 300
SELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKE
Sbjct: 241 SELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKE 300
Query: 301 LPKPRHVFRTRVPRKQAL 318
LPKPRHVFR + +++
Sbjct: 301 LPKPRHVFRRKTASSRSI 318
>gi|55741567 leucine rich repeat containing 27 isoform a [Homo
sapiens]
Length = 530
Score = 619 bits (1596), Expect = e-177
Identities = 309/318 (97%), Positives = 313/318 (98%)
Query: 1 MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRL 60
MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRL
Sbjct: 1 MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRL 60
Query: 61 EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL
Sbjct: 61 EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
Query: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRN 180
LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRN
Sbjct: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRN 180
Query: 181 PTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDL 240
PTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDL
Sbjct: 181 PTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDL 240
Query: 241 SELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKE 300
SELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKE
Sbjct: 241 SELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKE 300
Query: 301 LPKPRHVFRTRVPRKQAL 318
LPKPRHVFR + +++
Sbjct: 301 LPKPRHVFRRKTASSRSI 318
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 69.7 bits (169), Expect = 4e-12
Identities = 42/109 (38%), Positives = 62/109 (56%), Gaps = 1/109 (0%)
Query: 61 EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
E + ++ SL++L+++ N L +P + PNL LD R+N +K LP I Q LK L
Sbjct: 392 EHIRKLQSLKELYIENNHLEYLPVSLGSM-PNLEVLDCRHNLLKQLPDAICQAQALKELR 450
Query: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLR 169
LE N + LP L S+ LK L L P+E PP+ V +G AI ++L+
Sbjct: 451 LEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLK 499
Score = 48.1 bits (113), Expect = 1e-05
Identities = 45/128 (35%), Positives = 67/128 (52%), Gaps = 8/128 (6%)
Query: 36 HKGVGGIIFSSSPILDLSESGLC--RLEEVFRI----PSLQQLHLQRNALCVIPQDFFQL 89
H + I S + + ++E GL RLE+V R+ SL L+L L + + F+
Sbjct: 243 HNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRL-RGSFRC 301
Query: 90 LPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCP- 148
L NL +LDL N + P I A ++L+ L L+ N I LP ELGS++ LK L L
Sbjct: 302 LVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEF 361
Query: 149 LEFPPQLV 156
L FP +++
Sbjct: 362 LSFPEEVL 369
Score = 46.2 bits (108), Expect = 5e-05
Identities = 42/143 (29%), Positives = 70/143 (48%), Gaps = 7/143 (4%)
Query: 43 IFSSSPILDLSESGL--CRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRY 100
+ SS LDLS + + L V + +L++L L + L IP F+ L +L L L
Sbjct: 92 LLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTG 151
Query: 101 NRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKG 160
N +K LP I L+ + L+RN ++ P EL + TL+ ++L + P+ +
Sbjct: 152 NHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGH-- 209
Query: 161 LVAIQRFLRMWAVEHSLPRNPTS 183
L +Q+F + ++LP P S
Sbjct: 210 LTGLQKF---YMASNNLPVLPAS 229
Score = 46.2 bits (108), Expect = 5e-05
Identities = 30/97 (30%), Positives = 49/97 (50%), Gaps = 1/97 (1%)
Query: 58 CRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLK 117
C +E+ L++++L+RN V PQ+ +L L +DL N+I A+P IG L+
Sbjct: 156 CLPKEIVNQTKLREIYLKRNQFEVFPQELC-VLYTLEIIDLDENKIGAIPEEIGHLTGLQ 214
Query: 118 TLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQ 154
+ N + +LP L + L L+L H L P+
Sbjct: 215 KFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPK 251
Score = 40.8 bits (94), Expect = 0.002
Identities = 26/78 (33%), Positives = 42/78 (53%), Gaps = 2/78 (2%)
Query: 50 LDLSESGLCRLE-EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
+D S L + E+F L+++HL+ N + IPQ+ Q L N+ L L N +++L
Sbjct: 30 IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQE-IQRLKNIRVLYLDKNNLRSLCP 88
Query: 109 GIGAHQHLKTLLLERNPI 126
+G L++L L NPI
Sbjct: 89 ALGLLSSLESLDLSYNPI 106
Score = 40.4 bits (93), Expect = 0.003
Identities = 36/100 (36%), Positives = 51/100 (51%), Gaps = 2/100 (2%)
Query: 44 FSSSPILDLSESGLCRLEEVFR-IPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNR 102
++S +L L +GL RL FR + +L+ L L +N L P L NL L L N+
Sbjct: 279 WTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICAL-KNLEVLGLDDNK 337
Query: 103 IKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKAL 142
I LPS +G+ LK L L N P E+ S+ +L+ L
Sbjct: 338 IGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKL 377
Score = 40.4 bits (93), Expect = 0.003
Identities = 33/113 (29%), Positives = 55/113 (48%), Gaps = 3/113 (2%)
Query: 49 ILDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQL--LPNLTWLDLRYNRIKA 105
+L L ++ + +L E+ + L+ L L N P++ L L L + ++
Sbjct: 330 VLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTY 389
Query: 106 LPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQ 158
+P I Q LK L +E N ++ LPV LGS+ L+ L+ RH L+ P + Q
Sbjct: 390 VPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQ 442
>gi|53729363 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 68.6 bits (166), Expect = 9e-12
Identities = 48/144 (33%), Positives = 79/144 (54%), Gaps = 5/144 (3%)
Query: 49 ILDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALP 107
+LDL ++ L L +++ ++ +LQ L+++RN L +P+ L L L+++ N++K LP
Sbjct: 85 VLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLT-QLQTLNVKDNKLKELP 143
Query: 108 SGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRF 167
+G + L+TL + N I+ LP L V TL+ L+L + +PP+ V G AI +F
Sbjct: 144 DTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQF 203
Query: 168 LRMWAVEHSLPRNPTSQEAPPVRE 191
L E L P SQ P+ E
Sbjct: 204 L---CKESGLEYYPPSQYLLPILE 224
Score = 46.6 bits (109), Expect = 4e-05
Identities = 37/117 (31%), Positives = 55/117 (47%), Gaps = 12/117 (10%)
Query: 49 ILDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLLPN---------LTWLDLR 99
ILD+S+ C L E+ LQ+ L V LLP + LDL
Sbjct: 33 ILDISK---CELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLH 89
Query: 100 YNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLV 156
N++ ALP +G L+ L +ERN + LP +G++T L+ LN++ L+ P V
Sbjct: 90 DNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTV 146
>gi|53729361 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 68.6 bits (166), Expect = 9e-12
Identities = 48/144 (33%), Positives = 79/144 (54%), Gaps = 5/144 (3%)
Query: 49 ILDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALP 107
+LDL ++ L L +++ ++ +LQ L+++RN L +P+ L L L+++ N++K LP
Sbjct: 85 VLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLT-QLQTLNVKDNKLKELP 143
Query: 108 SGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRF 167
+G + L+TL + N I+ LP L V TL+ L+L + +PP+ V G AI +F
Sbjct: 144 DTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQF 203
Query: 168 LRMWAVEHSLPRNPTSQEAPPVRE 191
L E L P SQ P+ E
Sbjct: 204 L---CKESGLEYYPPSQYLLPILE 224
Score = 46.6 bits (109), Expect = 4e-05
Identities = 37/117 (31%), Positives = 55/117 (47%), Gaps = 12/117 (10%)
Query: 49 ILDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLLPN---------LTWLDLR 99
ILD+S+ C L E+ LQ+ L V LLP + LDL
Sbjct: 33 ILDISK---CELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLH 89
Query: 100 YNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLV 156
N++ ALP +G L+ L +ERN + LP +G++T L+ LN++ L+ P V
Sbjct: 90 DNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTV 146
>gi|53729359 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 68.6 bits (166), Expect = 9e-12
Identities = 48/144 (33%), Positives = 79/144 (54%), Gaps = 5/144 (3%)
Query: 49 ILDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALP 107
+LDL ++ L L +++ ++ +LQ L+++RN L +P+ L L L+++ N++K LP
Sbjct: 85 VLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLT-QLQTLNVKDNKLKELP 143
Query: 108 SGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRF 167
+G + L+TL + N I+ LP L V TL+ L+L + +PP+ V G AI +F
Sbjct: 144 DTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQF 203
Query: 168 LRMWAVEHSLPRNPTSQEAPPVRE 191
L E L P SQ P+ E
Sbjct: 204 L---CKESGLEYYPPSQYLLPILE 224
Score = 46.6 bits (109), Expect = 4e-05
Identities = 37/117 (31%), Positives = 55/117 (47%), Gaps = 12/117 (10%)
Query: 49 ILDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLLPN---------LTWLDLR 99
ILD+S+ C L E+ LQ+ L V LLP + LDL
Sbjct: 33 ILDISK---CELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLH 89
Query: 100 YNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLV 156
N++ ALP +G L+ L +ERN + LP +G++T L+ LN++ L+ P V
Sbjct: 90 DNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTV 146
>gi|28872863 CCR4-NOT transcription complex, subunit 6 [Homo
sapiens]
Length = 557
Score = 58.9 bits (141), Expect = 7e-09
Identities = 34/87 (39%), Positives = 52/87 (59%), Gaps = 1/87 (1%)
Query: 63 VFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLE 122
++ + L LHL N+L IP D +L NL +LDL N+I++LP+ +G L+ L L
Sbjct: 47 LWSLTHLTALHLSDNSLSRIPSDIAKL-HNLVYLDLSSNKIRSLPAELGNMVSLRELHLN 105
Query: 123 RNPIKMLPVELGSVTTLKALNLRHCPL 149
N +++LP ELG + L+ L L+ PL
Sbjct: 106 NNLLRVLPFELGKLFQLQTLGLKGNPL 132
Score = 39.3 bits (90), Expect = 0.006
Identities = 24/64 (37%), Positives = 35/64 (54%)
Query: 90 LPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPL 149
L +LT L L N + +PS I +L L L N I+ LP ELG++ +L+ L+L + L
Sbjct: 50 LTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLL 109
Query: 150 EFPP 153
P
Sbjct: 110 RVLP 113
>gi|115583679 CCR4-NOT transcription complex, subunit 6-like [Homo
sapiens]
Length = 555
Score = 58.9 bits (141), Expect = 7e-09
Identities = 34/87 (39%), Positives = 52/87 (59%), Gaps = 1/87 (1%)
Query: 63 VFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLE 122
++ + L LHL N L IP D +L NL +LDL N++++LP+ +G L+ LLL
Sbjct: 52 LWSLTHLTALHLNDNYLSRIPPDIAKL-HNLVYLDLSSNKLRSLPAELGNMVSLRELLLN 110
Query: 123 RNPIKMLPVELGSVTTLKALNLRHCPL 149
N +++LP ELG + L+ L L+ PL
Sbjct: 111 NNLLRVLPYELGRLFQLQTLGLKGNPL 137
Score = 35.0 bits (79), Expect = 0.11
Identities = 22/64 (34%), Positives = 33/64 (51%)
Query: 90 LPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPL 149
L +LT L L N + +P I +L L L N ++ LP ELG++ +L+ L L + L
Sbjct: 55 LTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLL 114
Query: 150 EFPP 153
P
Sbjct: 115 RVLP 118
>gi|167466264 leucine rich repeat containing 18 [Homo sapiens]
Length = 261
Score = 56.6 bits (135), Expect = 4e-08
Identities = 48/163 (29%), Positives = 75/163 (46%), Gaps = 10/163 (6%)
Query: 42 IIFSSSPILDLSESGLCRLEE-VFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRY 100
I F LDLS+ G+ + + R+ + +L L RN + IP D NL WLDL
Sbjct: 24 ITFDGKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIP-DSISKFQNLRWLDLHS 82
Query: 101 NRIKALPSGIGAHQHLKTLLLERNPIKM--LPVELGSVTTLKALNLRHCPLEFPPQLVVQ 158
N I LP IG L L + N + LPVEL + ++A+NL L+ P
Sbjct: 83 NYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTT--- 139
Query: 159 KGLVAIQRFLRMWAVEHSLPRNPTS-QEAPPVREMTLRDLPSP 200
L A++ + ++ L P S + P ++++ ++ P P
Sbjct: 140 --LGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFP 180
Score = 42.4 bits (98), Expect = 7e-04
Identities = 35/128 (27%), Positives = 67/128 (52%), Gaps = 6/128 (4%)
Query: 50 LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCV--IPQDFFQLLPNLTWLDLRYNRIKAL 106
LDL + + +L E + ++ SL L++ N L +P + QL N+ ++L N + ++
Sbjct: 78 LDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQL-KNIRAVNLGLNHLDSV 136
Query: 107 PSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQR 166
P+ +GA + L + L N + +PV + + LK LN++ P FP + + +I+R
Sbjct: 137 PTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNP--FPKPGESEIFIDSIRR 194
Query: 167 FLRMWAVE 174
++ VE
Sbjct: 195 LENLYVVE 202
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 56.6 bits (135), Expect = 4e-08
Identities = 44/140 (31%), Positives = 76/140 (54%), Gaps = 4/140 (2%)
Query: 49 ILDLSESGLCRLEEV-FRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALP 107
+LDL + L + V +R+ SL L+L+ N + + +D + L L+ L +R N+IK LP
Sbjct: 173 MLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDI-KNLSKLSMLSIRENKIKQLP 231
Query: 108 SGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCP-LEFPPQLVVQKGLVAI-Q 165
+ IG +L TL + N ++ LP E+G+ T + L+L+H L+ P + L +
Sbjct: 232 AEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGL 291
Query: 166 RFLRMWAVEHSLPRNPTSQE 185
R+ R+ A+ SL + +E
Sbjct: 292 RYNRLSAIPRSLAKCSALEE 311
Score = 54.7 bits (130), Expect = 1e-07
Identities = 49/167 (29%), Positives = 79/167 (47%), Gaps = 14/167 (8%)
Query: 52 LSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIG 111
+ E CR E R L L + ++ ++P +L LT L L N++++LP+ +G
Sbjct: 91 IKELNKCREENSMR------LDLSKRSIHILPSSIKELT-QLTELYLYSNKLQSLPAEVG 143
Query: 112 AHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVA--IQRFLR 169
+L TL L N + LP L ++ L+ L+LRH L P +V + + RF R
Sbjct: 144 CLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNR 203
Query: 170 MWAVEHSLPRNPTSQEAPPVREMTLRDLPSPGLELSG----DHASNQ 212
+ VE + +N + +RE ++ LP+ EL D A NQ
Sbjct: 204 ITTVEKDI-KNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQ 249
Score = 53.9 bits (128), Expect = 2e-07
Identities = 38/106 (35%), Positives = 55/106 (51%), Gaps = 2/106 (1%)
Query: 50 LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
L LSE+ L L + + + L+ L L+ N L IP ++L +LT L LR+NRI +
Sbjct: 151 LALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRL-DSLTTLYLRFNRITTVEK 209
Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQ 154
I L L + N IK LP E+G + L L++ H LE P+
Sbjct: 210 DIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPK 255
Score = 47.0 bits (110), Expect = 3e-05
Identities = 38/106 (35%), Positives = 55/106 (51%), Gaps = 4/106 (3%)
Query: 50 LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
LD++ + L L +E+ + L LQ N L +P D L +L+ L LRYNR+ A+P
Sbjct: 243 LDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLP-DTIGNLSSLSRLGLRYNRLSAIPR 301
Query: 109 GIGAHQHLKTLLLERNPIKMLPVE-LGSVTTLKALNL-RHCPLEFP 152
+ L+ L LE N I LP L S+ L +L L R+C +P
Sbjct: 302 SLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYP 347
Score = 44.7 bits (104), Expect = 1e-04
Identities = 44/161 (27%), Positives = 73/161 (45%), Gaps = 28/161 (17%)
Query: 35 VHKGVGGIIFSSSPILDLSESGLCRLEE-VFRIPSLQQLHLQRNALCVIPQDFFQLLPNL 93
+ + V G++ S +L LS + L +L + + L++L L+ N L +P + L +L
Sbjct: 417 IPEDVSGLV--SLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEI-AYLKDL 473
Query: 94 TWLDLRYNRIKALPSG-----------------------IGAHQHLKTLLLERNP-IKML 129
L L N++ LP G IG ++L+ L L NP + L
Sbjct: 474 QKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSL 533
Query: 130 PVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRM 170
P EL + L +++ +CPL P +V G I +FL+M
Sbjct: 534 PFELALCSKLSIMSIENCPLSHLPPQIVAGGPSFIIQFLKM 574
Score = 43.9 bits (102), Expect = 2e-04
Identities = 31/87 (35%), Positives = 48/87 (55%), Gaps = 1/87 (1%)
Query: 68 SLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIK 127
S+ +L+L N L IP+D L+ +L L L N +K LP G+G + L+ L LE N ++
Sbjct: 403 SMVELNLATNQLTKIPEDVSGLV-SLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLE 461
Query: 128 MLPVELGSVTTLKALNLRHCPLEFPPQ 154
LP E+ + L+ L L + L P+
Sbjct: 462 SLPNEIAYLKDLQKLVLTNNQLTTLPR 488
Score = 43.1 bits (100), Expect = 4e-04
Identities = 32/96 (33%), Positives = 52/96 (54%), Gaps = 2/96 (2%)
Query: 50 LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
L+L+ + L ++ E+V + SL+ L L N L +P L L LDL N++++LP+
Sbjct: 407 LNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLR-KLRELDLEENKLESLPN 465
Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNL 144
I + L+ L+L N + LP +G +T L L L
Sbjct: 466 EIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGL 501
Score = 37.0 bits (84), Expect = 0.030
Identities = 30/111 (27%), Positives = 53/111 (47%), Gaps = 2/111 (1%)
Query: 45 SSSPILDLSESGLCRLE-EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRI 103
S +L + E+ + +L E+ + +L L + N L +P++ +T LDL++N +
Sbjct: 215 SKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCT-QITNLDLQHNEL 273
Query: 104 KALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQ 154
LP IG L L L N + +P L + L+ LNL + + P+
Sbjct: 274 LDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPE 324
Score = 37.0 bits (84), Expect = 0.030
Identities = 32/123 (26%), Positives = 59/123 (47%), Gaps = 27/123 (21%)
Query: 68 SLQQLHLQRNALCVIPQDF----------------FQLLP--------NLTWLDLRYNRI 103
+L++L+L+ N + +P+ FQL P + L++ +NRI
Sbjct: 308 ALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRI 367
Query: 104 KALPSGIGAH-QHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLV 162
+P GI + + L L ++ N + LP++ G+ T++ LNL L P+ V GLV
Sbjct: 368 NKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDV--SGLV 425
Query: 163 AIQ 165
+++
Sbjct: 426 SLE 428
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 55.5 bits (132), Expect = 8e-08
Identities = 57/186 (30%), Positives = 85/186 (45%), Gaps = 10/186 (5%)
Query: 50 LDLSESGLCRLEE-VFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
LDLS + L L V ++ L L L N L +P+ LP LT+L + +NR++ LP
Sbjct: 130 LDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEAL-GALPALTFLTVTHNRLQTLPP 188
Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLE-FPPQLVVQKGLVAIQRF 167
+GA L+ L L +N + LP E+G + +L LNL L+ P L + L +
Sbjct: 189 ALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLH 248
Query: 168 LRMWA-VEHSLPRNPTSQEAPPVREMTLRDLP-----SPGLELSGDHASNQGAVNAQDPE 221
+ A V L R P +R+ LRDLP +P + L G+ P
Sbjct: 249 SNLLASVPADLARLPLLTRL-DLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPV 307
Query: 222 GAVMKE 227
A++ E
Sbjct: 308 AALIPE 313
Score = 38.9 bits (89), Expect = 0.008
Identities = 24/67 (35%), Positives = 36/67 (53%), Gaps = 1/67 (1%)
Query: 90 LPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPL 149
L +L LDL +N ++ LP+ + + L LLL N + LP LG++ L L + H L
Sbjct: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
Query: 150 E-FPPQL 155
+ PP L
Sbjct: 184 QTLPPAL 190
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 55.5 bits (132), Expect = 8e-08
Identities = 57/186 (30%), Positives = 85/186 (45%), Gaps = 10/186 (5%)
Query: 50 LDLSESGLCRLEE-VFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
LDLS + L L V ++ L L L N L +P+ LP LT+L + +NR++ LP
Sbjct: 130 LDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEAL-GALPALTFLTVTHNRLQTLPP 188
Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLE-FPPQLVVQKGLVAIQRF 167
+GA L+ L L +N + LP E+G + +L LNL L+ P L + L +
Sbjct: 189 ALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLH 248
Query: 168 LRMWA-VEHSLPRNPTSQEAPPVREMTLRDLP-----SPGLELSGDHASNQGAVNAQDPE 221
+ A V L R P +R+ LRDLP +P + L G+ P
Sbjct: 249 SNLLASVPADLARLPLLTRL-DLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPV 307
Query: 222 GAVMKE 227
A++ E
Sbjct: 308 AALIPE 313
Score = 38.9 bits (89), Expect = 0.008
Identities = 24/67 (35%), Positives = 36/67 (53%), Gaps = 1/67 (1%)
Query: 90 LPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPL 149
L +L LDL +N ++ LP+ + + L LLL N + LP LG++ L L + H L
Sbjct: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
Query: 150 E-FPPQL 155
+ PP L
Sbjct: 184 QTLPPAL 190
>gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
Length = 367
Score = 55.5 bits (132), Expect = 8e-08
Identities = 31/88 (35%), Positives = 54/88 (61%), Gaps = 1/88 (1%)
Query: 69 LQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKM 128
L++L+++RN+L +P++ Q LPNL L L N I +P IG+ L+ L L N +++
Sbjct: 43 LERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEI 102
Query: 129 LPVELGSVTTLKALNLRHCPLEF-PPQL 155
+ E+G + L+ L L + L+F PP++
Sbjct: 103 VCPEIGRLRALRHLRLANNQLQFLPPEV 130
Score = 44.3 bits (103), Expect = 2e-04
Identities = 34/124 (27%), Positives = 63/124 (50%), Gaps = 5/124 (4%)
Query: 65 RIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERN 124
++P+L +L+L N + V+P+ L+ L LDL N ++ + IG + L+ L L N
Sbjct: 63 KLPNLVELYLHSNNIVVVPEAIGSLV-KLQCLDLSDNALEIVCPEIGRLRALRHLRLANN 121
Query: 125 PIKMLPVELGSVTTLKALNLRHCPLEFPPQ---LVVQKGLVAIQRFLRMWAVEHSLPRNP 181
++ LP E+G + L+ L++ L P+ + + + + R R+W V L + P
Sbjct: 122 QLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDR-NRLWYVPRHLCQLP 180
Query: 182 TSQE 185
+ E
Sbjct: 181 SLNE 184
Score = 40.4 bits (93), Expect = 0.003
Identities = 32/105 (30%), Positives = 52/105 (49%), Gaps = 2/105 (1%)
Query: 50 LDLSESGL-CRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
LDLS++ L E+ R+ +L+ L L N L +P + L L LD+ NR+ LP
Sbjct: 93 LDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDL-KELQTLDISTNRLLTLPE 151
Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPP 153
+ L+ L ++RN + +P L + +L L++ L F P
Sbjct: 152 RLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLP 196
Score = 38.5 bits (88), Expect = 0.010
Identities = 29/83 (34%), Positives = 45/83 (54%), Gaps = 3/83 (3%)
Query: 50 LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
LD+S + L L E + SLQ L + RN L +P+ QL P+L L + NR+ LP
Sbjct: 139 LDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQL-PSLNELSMAGNRLAFLPL 197
Query: 109 GIGAHQHLKTLLLERN-PIKMLP 130
+G + L+ + ++ N +K LP
Sbjct: 198 DLGRSRELQYVYVDNNIHLKGLP 220
Score = 31.2 bits (69), Expect = 1.6
Identities = 21/73 (28%), Positives = 35/73 (47%), Gaps = 1/73 (1%)
Query: 62 EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLL 121
EV + LQ L + N L +P+ L +L +L + NR+ +P + L L +
Sbjct: 129 EVGDLKELQTLDISTNRLLTLPERLHMCL-SLQYLTVDRNRLWYVPRHLCQLPSLNELSM 187
Query: 122 ERNPIKMLPVELG 134
N + LP++LG
Sbjct: 188 AGNRLAFLPLDLG 200
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 53.5 bits (127), Expect = 3e-07
Identities = 40/125 (32%), Positives = 67/125 (53%), Gaps = 4/125 (3%)
Query: 25 RSLPATPSKDVHKGVGGIIFSSSP--ILDLSESGLCRL-EEVFRIPSLQQLHLQRNALCV 81
R++ A + + GV IF +LDLS + L E+ ++ L+L N++
Sbjct: 82 RAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDT 141
Query: 82 IPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPV-ELGSVTTLK 140
IP F L +L +LDL NR+++LP + HL+TL+L NP+ + +L ++T L+
Sbjct: 142 IPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQ 201
Query: 141 ALNLR 145
L+LR
Sbjct: 202 TLHLR 206
Score = 40.8 bits (94), Expect = 0.002
Identities = 36/130 (27%), Positives = 60/130 (46%), Gaps = 5/130 (3%)
Query: 66 IPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNP 125
+ +L + L N L +P+ + L P+L L+L N+I L I H++TL L RN
Sbjct: 222 LSNLADVDLSCNDLTRVPECLYTL-PSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQ 280
Query: 126 IKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRNPTSQ- 184
+ LP + ++ LK L L L+F + G+ + A ++L P S
Sbjct: 281 LTSLPSAICKLSKLKKLYLNSNKLDFDG---LPSGIGKLTNLEEFMAANNNLELVPESLC 337
Query: 185 EAPPVREMTL 194
P +R++ L
Sbjct: 338 RCPKLRKLVL 347
Score = 37.4 bits (85), Expect = 0.023
Identities = 28/107 (26%), Positives = 51/107 (47%), Gaps = 4/107 (3%)
Query: 61 EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
E V + SL+ L L R LC +P++ L L L + +N + L + + L+ ++
Sbjct: 27 ENVKAMTSLRWLKLNRTGLCYLPEE-LAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIV 85
Query: 121 LERNPIKM--LPVELGSVTTLKALNLRHCPL-EFPPQLVVQKGLVAI 164
N +K +P ++ + L L+L H L E P +L K ++ +
Sbjct: 86 ARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVL 132
Score = 32.7 bits (73), Expect = 0.56
Identities = 26/90 (28%), Positives = 43/90 (47%), Gaps = 3/90 (3%)
Query: 69 LQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIK--ALPSGIGAHQHLKTLLLERNPI 126
++ L+L RN L +P +L L L L N++ LPSGIG +L+ + N +
Sbjct: 271 VETLNLSRNQLTSLPSAICKL-SKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNL 329
Query: 127 KMLPVELGSVTTLKALNLRHCPLEFPPQLV 156
+++P L L+ L L L P+ +
Sbjct: 330 ELVPESLCRCPKLRKLVLNKNHLVTLPEAI 359
>gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
Length = 803
Score = 53.5 bits (127), Expect = 3e-07
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 5/102 (4%)
Query: 58 CRLEEV----FRIPSLQQLHLQRNALCVIPQDF-FQLLPNLTWLDLRYNRIKALPSGIGA 112
C LE + F + +L +L L+ N L + + FQ L NL+ L L +N I +P+ IGA
Sbjct: 595 CDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGA 654
Query: 113 HQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQ 154
+L+ L L+ N I+ LP++L T L L+L + L F P+
Sbjct: 655 LSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPE 696
Score = 44.3 bits (103), Expect = 2e-04
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 2/95 (2%)
Query: 62 EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLL 121
++F L L L N L IP++ Q L NL + + N I+ LP G+ + L+ LLL
Sbjct: 674 QLFLCTKLHYLDLSYNHLTFIPEEI-QYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLL 732
Query: 122 ERNPIKMLPVELGSVTTLKALNLRHCPLE-FPPQL 155
+N + L +G ++ L L L LE PP+L
Sbjct: 733 GKNSLMNLSPHVGELSNLTHLELIGNYLETLPPEL 767
Score = 30.8 bits (68), Expect = 2.1
Identities = 24/71 (33%), Positives = 38/71 (53%), Gaps = 3/71 (4%)
Query: 63 VFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLK--TLL 120
+F+ LQ L L +N+L + +L NLT L+L N ++ LP + Q LK L+
Sbjct: 721 LFQCKKLQCLLLGKNSLMNLSPHVGEL-SNLTHLELIGNYLETLPPELEGCQSLKRNCLI 779
Query: 121 LERNPIKMLPV 131
+E N + LP+
Sbjct: 780 VEENLLNTLPL 790
>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
sapiens]
Length = 803
Score = 53.5 bits (127), Expect = 3e-07
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 5/102 (4%)
Query: 58 CRLEEV----FRIPSLQQLHLQRNALCVIPQDF-FQLLPNLTWLDLRYNRIKALPSGIGA 112
C LE + F + +L +L L+ N L + + FQ L NL+ L L +N I +P+ IGA
Sbjct: 595 CDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGA 654
Query: 113 HQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQ 154
+L+ L L+ N I+ LP++L T L L+L + L F P+
Sbjct: 655 LSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPE 696
Score = 44.3 bits (103), Expect = 2e-04
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 2/95 (2%)
Query: 62 EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLL 121
++F L L L N L IP++ Q L NL + + N I+ LP G+ + L+ LLL
Sbjct: 674 QLFLCTKLHYLDLSYNHLTFIPEEI-QYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLL 732
Query: 122 ERNPIKMLPVELGSVTTLKALNLRHCPLE-FPPQL 155
+N + L +G ++ L L L LE PP+L
Sbjct: 733 GKNSLMNLSPHVGELSNLTHLELIGNYLETLPPEL 767
Score = 30.8 bits (68), Expect = 2.1
Identities = 24/71 (33%), Positives = 38/71 (53%), Gaps = 3/71 (4%)
Query: 63 VFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLK--TLL 120
+F+ LQ L L +N+L + +L NLT L+L N ++ LP + Q LK L+
Sbjct: 721 LFQCKKLQCLLLGKNSLMNLSPHVGEL-SNLTHLELIGNYLETLPPELEGCQSLKRNCLI 779
Query: 121 LERNPIKMLPV 131
+E N + LP+
Sbjct: 780 VEENLLNTLPL 790
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 53.1 bits (126), Expect = 4e-07
Identities = 40/119 (33%), Positives = 61/119 (51%), Gaps = 7/119 (5%)
Query: 42 IIFSSSPILDLSESGLCRLE------EVFRIPSLQQLHLQRNALCVIPQDF-FQLLPNLT 94
++ S + +L+E L R + +F + +LQ++ L+ N L I + FQ L LT
Sbjct: 583 VLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLT 642
Query: 95 WLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPP 153
L L YN I +P IG +L+ L L RN I+ +P +L L+ L+L H L F P
Sbjct: 643 CLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLP 701
Score = 53.1 bits (126), Expect = 4e-07
Identities = 33/95 (34%), Positives = 53/95 (55%), Gaps = 1/95 (1%)
Query: 62 EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLL 121
++ + +L++L+L RN + IP F L +LDL +N + LP+ IG Q+L+ L +
Sbjct: 657 QIGNLTNLERLYLNRNKIEKIPTQLFYCR-KLRYLDLSHNNLTFLPADIGLLQNLQNLAI 715
Query: 122 ERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLV 156
N I+ LP EL L+AL+L + L+ P V
Sbjct: 716 TANRIETLPPELFQCRKLRALHLGNNVLQSLPSRV 750
Score = 45.8 bits (107), Expect = 6e-05
Identities = 32/92 (34%), Positives = 46/92 (50%), Gaps = 1/92 (1%)
Query: 62 EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLL 121
++F L+ L L N L +P D LL NL L + NRI+ LP + + L+ L L
Sbjct: 680 QLFYCRKLRYLDLSHNNLTFLPADI-GLLQNLQNLAITANRIETLPPELFQCRKLRALHL 738
Query: 122 ERNPIKMLPVELGSVTTLKALNLRHCPLEFPP 153
N ++ LP +G +T L + LR LE P
Sbjct: 739 GNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770
Score = 45.4 bits (106), Expect = 8e-05
Identities = 33/96 (34%), Positives = 50/96 (52%), Gaps = 2/96 (2%)
Query: 50 LDLSESGLCRLE-EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
LDLS + L L ++ + +LQ L + N + +P + FQ L L L N +++LPS
Sbjct: 690 LDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCR-KLRALHLGNNVLQSLPS 748
Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNL 144
+G +L + L N ++ LPVELG LK L
Sbjct: 749 RVGELTNLTQIELRGNRLECLPVELGECPLLKRSGL 784
Score = 40.0 bits (92), Expect = 0.004
Identities = 34/119 (28%), Positives = 58/119 (48%), Gaps = 5/119 (4%)
Query: 50 LDLSESGLCRLEEVFRIPSLQQL---HLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKAL 106
+DL ++ L +EE+ L +L L N + IP L NL L L N+I+ +
Sbjct: 619 IDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLT-NLERLYLNRNKIEKI 677
Query: 107 PSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLE-FPPQLVVQKGLVAI 164
P+ + + L+ L L N + LP ++G + L+ L + +E PP+L + L A+
Sbjct: 678 PTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRAL 736
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 53.1 bits (126), Expect = 4e-07
Identities = 40/119 (33%), Positives = 61/119 (51%), Gaps = 7/119 (5%)
Query: 42 IIFSSSPILDLSESGLCRLE------EVFRIPSLQQLHLQRNALCVIPQDF-FQLLPNLT 94
++ S + +L+E L R + +F + +LQ++ L+ N L I + FQ L LT
Sbjct: 583 VLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLT 642
Query: 95 WLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPP 153
L L YN I +P IG +L+ L L RN I+ +P +L L+ L+L H L F P
Sbjct: 643 CLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLP 701
Score = 53.1 bits (126), Expect = 4e-07
Identities = 33/95 (34%), Positives = 53/95 (55%), Gaps = 1/95 (1%)
Query: 62 EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLL 121
++ + +L++L+L RN + IP F L +LDL +N + LP+ IG Q+L+ L +
Sbjct: 657 QIGNLTNLERLYLNRNKIEKIPTQLFYCR-KLRYLDLSHNNLTFLPADIGLLQNLQNLAI 715
Query: 122 ERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLV 156
N I+ LP EL L+AL+L + L+ P V
Sbjct: 716 TANRIETLPPELFQCRKLRALHLGNNVLQSLPSRV 750
Score = 45.8 bits (107), Expect = 6e-05
Identities = 32/92 (34%), Positives = 46/92 (50%), Gaps = 1/92 (1%)
Query: 62 EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLL 121
++F L+ L L N L +P D LL NL L + NRI+ LP + + L+ L L
Sbjct: 680 QLFYCRKLRYLDLSHNNLTFLPADI-GLLQNLQNLAITANRIETLPPELFQCRKLRALHL 738
Query: 122 ERNPIKMLPVELGSVTTLKALNLRHCPLEFPP 153
N ++ LP +G +T L + LR LE P
Sbjct: 739 GNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770
Score = 45.4 bits (106), Expect = 8e-05
Identities = 33/96 (34%), Positives = 50/96 (52%), Gaps = 2/96 (2%)
Query: 50 LDLSESGLCRLE-EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
LDLS + L L ++ + +LQ L + N + +P + FQ L L L N +++LPS
Sbjct: 690 LDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCR-KLRALHLGNNVLQSLPS 748
Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNL 144
+G +L + L N ++ LPVELG LK L
Sbjct: 749 RVGELTNLTQIELRGNRLECLPVELGECPLLKRSGL 784
Score = 40.0 bits (92), Expect = 0.004
Identities = 34/119 (28%), Positives = 58/119 (48%), Gaps = 5/119 (4%)
Query: 50 LDLSESGLCRLEEVFRIPSLQQL---HLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKAL 106
+DL ++ L +EE+ L +L L N + IP L NL L L N+I+ +
Sbjct: 619 IDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLT-NLERLYLNRNKIEKI 677
Query: 107 PSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLE-FPPQLVVQKGLVAI 164
P+ + + L+ L L N + LP ++G + L+ L + +E PP+L + L A+
Sbjct: 678 PTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRAL 736
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 53.1 bits (126), Expect = 4e-07
Identities = 40/119 (33%), Positives = 61/119 (51%), Gaps = 7/119 (5%)
Query: 42 IIFSSSPILDLSESGLCRLE------EVFRIPSLQQLHLQRNALCVIPQDF-FQLLPNLT 94
++ S + +L+E L R + +F + +LQ++ L+ N L I + FQ L LT
Sbjct: 583 VLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLT 642
Query: 95 WLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPP 153
L L YN I +P IG +L+ L L RN I+ +P +L L+ L+L H L F P
Sbjct: 643 CLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLP 701
Score = 53.1 bits (126), Expect = 4e-07
Identities = 33/95 (34%), Positives = 53/95 (55%), Gaps = 1/95 (1%)
Query: 62 EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLL 121
++ + +L++L+L RN + IP F L +LDL +N + LP+ IG Q+L+ L +
Sbjct: 657 QIGNLTNLERLYLNRNKIEKIPTQLFYCR-KLRYLDLSHNNLTFLPADIGLLQNLQNLAI 715
Query: 122 ERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLV 156
N I+ LP EL L+AL+L + L+ P V
Sbjct: 716 TANRIETLPPELFQCRKLRALHLGNNVLQSLPSRV 750
Score = 45.8 bits (107), Expect = 6e-05
Identities = 32/92 (34%), Positives = 46/92 (50%), Gaps = 1/92 (1%)
Query: 62 EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLL 121
++F L+ L L N L +P D LL NL L + NRI+ LP + + L+ L L
Sbjct: 680 QLFYCRKLRYLDLSHNNLTFLPADI-GLLQNLQNLAITANRIETLPPELFQCRKLRALHL 738
Query: 122 ERNPIKMLPVELGSVTTLKALNLRHCPLEFPP 153
N ++ LP +G +T L + LR LE P
Sbjct: 739 GNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770
Score = 45.4 bits (106), Expect = 8e-05
Identities = 33/96 (34%), Positives = 50/96 (52%), Gaps = 2/96 (2%)
Query: 50 LDLSESGLCRLE-EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
LDLS + L L ++ + +LQ L + N + +P + FQ L L L N +++LPS
Sbjct: 690 LDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCR-KLRALHLGNNVLQSLPS 748
Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNL 144
+G +L + L N ++ LPVELG LK L
Sbjct: 749 RVGELTNLTQIELRGNRLECLPVELGECPLLKRSGL 784
Score = 40.0 bits (92), Expect = 0.004
Identities = 34/119 (28%), Positives = 58/119 (48%), Gaps = 5/119 (4%)
Query: 50 LDLSESGLCRLEEVFRIPSLQQL---HLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKAL 106
+DL ++ L +EE+ L +L L N + IP L NL L L N+I+ +
Sbjct: 619 IDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLT-NLERLYLNRNKIEKI 677
Query: 107 PSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLE-FPPQLVVQKGLVAI 164
P+ + + L+ L L N + LP ++G + L+ L + +E PP+L + L A+
Sbjct: 678 PTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRAL 736
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 53.1 bits (126), Expect = 4e-07
Identities = 35/94 (37%), Positives = 48/94 (51%), Gaps = 1/94 (1%)
Query: 61 EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
E + + +L L L+ N L +P QL L LDL N I LP IGA HLK L
Sbjct: 145 ENIGNLYNLASLELRENLLTYLPDSLTQLR-RLEELDLGNNEIYNLPESIGALLHLKDLW 203
Query: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQ 154
L+ N + LP E+G++ L L++ LE P+
Sbjct: 204 LDGNQLSELPQEIGNLKNLLCLDVSENRLERLPE 237
Score = 49.3 bits (116), Expect = 6e-06
Identities = 35/95 (36%), Positives = 50/95 (52%), Gaps = 2/95 (2%)
Query: 50 LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
LD+SE+ L RL EE+ + SL L + +N L IP D L L+ L + NR+ LP
Sbjct: 225 LDVSENRLERLPEEISGLTSLTDLVISQNLLETIP-DGIGKLKKLSILKVDQNRLTQLPE 283
Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALN 143
+G + L L+L N + LP +G + L LN
Sbjct: 284 AVGECESLTELVLTENQLLTLPKSIGKLKKLSNLN 318
Score = 42.4 bits (98), Expect = 7e-04
Identities = 32/108 (29%), Positives = 52/108 (48%), Gaps = 2/108 (1%)
Query: 50 LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
LDL + + L E + + L+ L L N L +PQ+ L NL LD+ NR++ LP
Sbjct: 179 LDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNL-KNLLCLDVSENRLERLPE 237
Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLV 156
I L L++ +N ++ +P +G + L L + L P+ V
Sbjct: 238 EISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAV 285
Score = 37.7 bits (86), Expect = 0.017
Identities = 32/107 (29%), Positives = 50/107 (46%), Gaps = 7/107 (6%)
Query: 49 ILDLSESGLCRLEE-VFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALP 107
IL + ++ L +L E V SL +L L N L +P+ +L L+ L+ N++ +LP
Sbjct: 270 ILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKL-KKLSNLNADRNKLVSLP 328
Query: 108 SGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALN-----LRHCPL 149
IG L + N + +P E+ T L L+ L H PL
Sbjct: 329 KEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPL 375
Score = 37.0 bits (84), Expect = 0.030
Identities = 30/117 (25%), Positives = 47/117 (40%), Gaps = 23/117 (19%)
Query: 61 EEVFRIP-SLQQLHLQRNALCVIPQDFFQLLP----------------------NLTWLD 97
EE++R SL++L L N L +P+ FFQL+ L LD
Sbjct: 29 EEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELD 88
Query: 98 LRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQ 154
+ N I +P I + L+ NP+ LP + L L++ L+ P+
Sbjct: 89 VSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPE 145
Score = 37.0 bits (84), Expect = 0.030
Identities = 29/96 (30%), Positives = 48/96 (50%), Gaps = 2/96 (2%)
Query: 50 LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
LD+S + + + E + +LQ N L +P+ F +L NLT L + +++LP
Sbjct: 87 LDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPEL-QNLTCLSVNDISLQSLPE 145
Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNL 144
IG +L +L L N + LP L + L+ L+L
Sbjct: 146 NIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDL 181
Score = 32.3 bits (72), Expect = 0.73
Identities = 46/169 (27%), Positives = 72/169 (42%), Gaps = 11/169 (6%)
Query: 50 LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
L L+E+ L L + + ++ L L+ RN L +P++ +LT +R NR+ +P+
Sbjct: 294 LVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCC-SLTVFCVRDNRLTRIPA 352
Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGL-VAIQRF 167
+ L L + N + LP+ S+T LK L + P L Q
Sbjct: 353 EVSQATELHVLDVAGNRLLHLPL---SLTALKLKALWLSDNQSQPLLTFQTDTDYTTGEK 409
Query: 168 LRMWAVEHSLPRNPTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVN 216
+ + LP PT QE P R L +L + D A N+ AVN
Sbjct: 410 ILTCVLLPQLPSEPTCQENLP-RCGALENLVND----VSDEAWNERAVN 453
Score = 29.6 bits (65), Expect = 4.8
Identities = 22/85 (25%), Positives = 40/85 (47%), Gaps = 1/85 (1%)
Query: 78 ALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVT 137
+L +P++ ++ +L L L N+++ LP L+ L L N I+ LP E+ +
Sbjct: 23 SLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFM 82
Query: 138 TLKALNLRHCPL-EFPPQLVVQKGL 161
L L++ + E P + K L
Sbjct: 83 QLVELDVSRNEIPEIPESISFCKAL 107
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 52.4 bits (124), Expect = 7e-07
Identities = 34/117 (29%), Positives = 60/117 (51%), Gaps = 4/117 (3%)
Query: 50 LDLSESGLCRLEEVF-RIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
LDL + + EV ++ L++ + N L IP F L LT+LD+ N I+ +
Sbjct: 189 LDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIP-GFIGSLKQLTYLDVSKNNIEMVEE 247
Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQ 165
GI ++L+ LLL N ++ LP +GS+ + L + L + P + GL++++
Sbjct: 248 GISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSI--GGLISVE 302
Score = 48.9 bits (115), Expect = 8e-06
Identities = 32/104 (30%), Positives = 53/104 (50%), Gaps = 2/104 (1%)
Query: 52 LSESGLCRLEEVF-RIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGI 110
LS + L +L E + ++ L + N L +P L+ ++ LD +N ++ALPS I
Sbjct: 260 LSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLI-SVEELDCSFNEVEALPSSI 318
Query: 111 GAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQ 154
G +L+T + N ++ LP E+GS + L L LE P+
Sbjct: 319 GQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPE 362
Score = 44.7 bits (104), Expect = 1e-04
Identities = 37/138 (26%), Positives = 65/138 (47%), Gaps = 8/138 (5%)
Query: 50 LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
L + E+ L L + + + S+++L N + +P QL NL +N ++ LP
Sbjct: 281 LKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLT-NLRTFAADHNYLQQLPP 339
Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFL 168
IG+ +++ L L N ++ LP E+G + LK +NL L+ P +Q+
Sbjct: 340 EIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP-----FSFTKLQQLT 394
Query: 169 RMWAVEH-SLPRNPTSQE 185
MW ++ S P P +E
Sbjct: 395 AMWLSDNQSKPLIPLQKE 412
Score = 43.9 bits (102), Expect = 2e-04
Identities = 34/110 (30%), Positives = 54/110 (49%), Gaps = 2/110 (1%)
Query: 50 LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
LD+S++G+ E + L + N + +P F QLL NLT L L ++ LP+
Sbjct: 97 LDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLL-NLTQLYLNDAFLEFLPA 155
Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQ 158
G L+ L L N +KMLP + +T L+ L+L P+++ Q
Sbjct: 156 NFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQ 205
Score = 40.0 bits (92), Expect = 0.004
Identities = 30/93 (32%), Positives = 41/93 (44%), Gaps = 1/93 (1%)
Query: 61 EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
+++F SL +L L N L +P L+ NL LD+ N I+ P I + L +
Sbjct: 63 KQLFNCQSLHKLSLPDNDLTTLPASIANLI-NLRELDVSKNGIQEFPENIKNCKVLTIVE 121
Query: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPP 153
NPI LP + L L L LEF P
Sbjct: 122 ASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLP 154
Score = 35.0 bits (79), Expect = 0.11
Identities = 29/117 (24%), Positives = 54/117 (46%), Gaps = 6/117 (5%)
Query: 65 RIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERN 124
R+ LQ L L+ N L ++P+ +L L LDL N +P + LK ++ N
Sbjct: 159 RLTKLQILELRENQLKMLPKTMNRLT-QLERLDLGSNEFTEVPEVLEQLSGLKEFWMDAN 217
Query: 125 PIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRNP 181
+ +P +GS+ L L++ +E +V++G+ + + +SL + P
Sbjct: 218 RLTFIPGFIGSLKQLTYLDVSKNNIE-----MVEEGISTCENLQDLLLSSNSLQQLP 269
Score = 34.3 bits (77), Expect = 0.19
Identities = 31/109 (28%), Positives = 54/109 (49%), Gaps = 2/109 (1%)
Query: 49 ILDLSESGLCRLEEVF-RIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALP 107
I++ S + + +L + F ++ +L QL+L L +P +F +L L L+LR N++K LP
Sbjct: 119 IVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLT-KLQILELRENQLKMLP 177
Query: 108 SGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLV 156
+ L+ L L N +P L ++ LK + L F P +
Sbjct: 178 KTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFI 226
Score = 32.3 bits (72), Expect = 0.73
Identities = 23/85 (27%), Positives = 41/85 (48%), Gaps = 1/85 (1%)
Query: 82 IPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKA 141
+P++ F L L L N+I+ LP + Q L L L N + LP + ++ L+
Sbjct: 37 VPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRE 96
Query: 142 LNL-RHCPLEFPPQLVVQKGLVAIQ 165
L++ ++ EFP + K L ++
Sbjct: 97 LDVSKNGIQEFPENIKNCKVLTIVE 121
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 52.4 bits (124), Expect = 7e-07
Identities = 34/117 (29%), Positives = 60/117 (51%), Gaps = 4/117 (3%)
Query: 50 LDLSESGLCRLEEVF-RIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
LDL + + EV ++ L++ + N L IP F L LT+LD+ N I+ +
Sbjct: 189 LDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIP-GFIGSLKQLTYLDVSKNNIEMVEE 247
Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQ 165
GI ++L+ LLL N ++ LP +GS+ + L + L + P + GL++++
Sbjct: 248 GISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSI--GGLISVE 302
Score = 48.9 bits (115), Expect = 8e-06
Identities = 32/104 (30%), Positives = 53/104 (50%), Gaps = 2/104 (1%)
Query: 52 LSESGLCRLEEVF-RIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGI 110
LS + L +L E + ++ L + N L +P L+ ++ LD +N ++ALPS I
Sbjct: 260 LSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLI-SVEELDCSFNEVEALPSSI 318
Query: 111 GAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQ 154
G +L+T + N ++ LP E+GS + L L LE P+
Sbjct: 319 GQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPE 362
Score = 44.7 bits (104), Expect = 1e-04
Identities = 37/138 (26%), Positives = 65/138 (47%), Gaps = 8/138 (5%)
Query: 50 LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
L + E+ L L + + + S+++L N + +P QL NL +N ++ LP
Sbjct: 281 LKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLT-NLRTFAADHNYLQQLPP 339
Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFL 168
IG+ +++ L L N ++ LP E+G + LK +NL L+ P +Q+
Sbjct: 340 EIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP-----FSFTKLQQLT 394
Query: 169 RMWAVEH-SLPRNPTSQE 185
MW ++ S P P +E
Sbjct: 395 AMWLSDNQSKPLIPLQKE 412
Score = 43.9 bits (102), Expect = 2e-04
Identities = 34/110 (30%), Positives = 54/110 (49%), Gaps = 2/110 (1%)
Query: 50 LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
LD+S++G+ E + L + N + +P F QLL NLT L L ++ LP+
Sbjct: 97 LDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLL-NLTQLYLNDAFLEFLPA 155
Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQ 158
G L+ L L N +KMLP + +T L+ L+L P+++ Q
Sbjct: 156 NFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQ 205
Score = 40.0 bits (92), Expect = 0.004
Identities = 30/93 (32%), Positives = 41/93 (44%), Gaps = 1/93 (1%)
Query: 61 EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
+++F SL +L L N L +P L+ NL LD+ N I+ P I + L +
Sbjct: 63 KQLFNCQSLHKLSLPDNDLTTLPASIANLI-NLRELDVSKNGIQEFPENIKNCKVLTIVE 121
Query: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPP 153
NPI LP + L L L LEF P
Sbjct: 122 ASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLP 154
Score = 35.0 bits (79), Expect = 0.11
Identities = 29/117 (24%), Positives = 54/117 (46%), Gaps = 6/117 (5%)
Query: 65 RIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERN 124
R+ LQ L L+ N L ++P+ +L L LDL N +P + LK ++ N
Sbjct: 159 RLTKLQILELRENQLKMLPKTMNRLT-QLERLDLGSNEFTEVPEVLEQLSGLKEFWMDAN 217
Query: 125 PIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRNP 181
+ +P +GS+ L L++ +E +V++G+ + + +SL + P
Sbjct: 218 RLTFIPGFIGSLKQLTYLDVSKNNIE-----MVEEGISTCENLQDLLLSSNSLQQLP 269
Score = 34.3 bits (77), Expect = 0.19
Identities = 31/109 (28%), Positives = 54/109 (49%), Gaps = 2/109 (1%)
Query: 49 ILDLSESGLCRLEEVF-RIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALP 107
I++ S + + +L + F ++ +L QL+L L +P +F +L L L+LR N++K LP
Sbjct: 119 IVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLT-KLQILELRENQLKMLP 177
Query: 108 SGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLV 156
+ L+ L L N +P L ++ LK + L F P +
Sbjct: 178 KTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFI 226
Score = 32.3 bits (72), Expect = 0.73
Identities = 23/85 (27%), Positives = 41/85 (48%), Gaps = 1/85 (1%)
Query: 82 IPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKA 141
+P++ F L L L N+I+ LP + Q L L L N + LP + ++ L+
Sbjct: 37 VPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRE 96
Query: 142 LNL-RHCPLEFPPQLVVQKGLVAIQ 165
L++ ++ EFP + K L ++
Sbjct: 97 LDVSKNGIQEFPENIKNCKVLTIVE 121
>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
Length = 347
Score = 52.4 bits (124), Expect = 7e-07
Identities = 35/97 (36%), Positives = 56/97 (57%), Gaps = 2/97 (2%)
Query: 49 ILDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALP 107
+L+L+ + L +L +EV R+ SL + + N L IP++ L NL L L YN++ +P
Sbjct: 111 LLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELC-FLENLVELQLNYNQLICIP 169
Query: 108 SGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNL 144
I + L+ LLL RN I +LP EL + L+ L++
Sbjct: 170 EEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDI 206
Score = 40.8 bits (94), Expect = 0.002
Identities = 31/108 (28%), Positives = 49/108 (45%), Gaps = 2/108 (1%)
Query: 61 EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
EE+ + SL+ LHL N +C L NL L+L N + LP + + L +
Sbjct: 77 EEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMS 136
Query: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFL 168
+ N + +P EL + L L L + L P+ + K L +Q+ L
Sbjct: 137 INYNQLASIPRELCFLENLVELQLNYNQLICIPEEI--KFLKKLQKLL 182
Score = 35.0 bits (79), Expect = 0.11
Identities = 22/63 (34%), Positives = 34/63 (53%)
Query: 92 NLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEF 151
N + L ++ +PS +G LKTL+L+ N I + EL ++T L LNL + LE
Sbjct: 15 NTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEE 74
Query: 152 PPQ 154
P+
Sbjct: 75 VPE 77
>gi|61742782 leucine rich repeat and death domain containing protein
isoform 2 [Homo sapiens]
Length = 753
Score = 52.0 bits (123), Expect = 9e-07
Identities = 50/166 (30%), Positives = 75/166 (45%), Gaps = 9/166 (5%)
Query: 69 LQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKM 128
L L L N L +P+ LP LT+L + +NR++ LP +GA L+ L L +N +
Sbjct: 4 LGALLLSHNCLSELPEAL-GALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDT 62
Query: 129 LPVELGSVTTLKALNLRHCPLE-FPPQLVVQKGLVAIQRFLRMWA-VEHSLPRNPTSQEA 186
LP E+G + +L LNL L+ P L + L + + A V L R P
Sbjct: 63 LPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRL 122
Query: 187 PPVREMTLRDLP-----SPGLELSGDHASNQGAVNAQDPEGAVMKE 227
+R+ LRDLP +P + L G+ P A++ E
Sbjct: 123 -DLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPE 167
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 52.0 bits (123), Expect = 9e-07
Identities = 38/118 (32%), Positives = 62/118 (52%), Gaps = 4/118 (3%)
Query: 32 SKDVHKGVGGIIFSSSPILDLSESGLCRLEEV---FRIPSLQQLHLQRNALCVIPQDFFQ 88
SK + K V + P +D+S+ G+ + +V F + + QL L N L ++P + +
Sbjct: 2 SKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAE 61
Query: 89 LLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRH 146
L NL L+ N+I+ LP+ I + Q LK L L N + LP GS+ L+ L+L +
Sbjct: 62 L-KNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTY 118
Score = 43.9 bits (102), Expect = 2e-04
Identities = 40/154 (25%), Positives = 68/154 (44%), Gaps = 10/154 (6%)
Query: 44 FSSSPILDLSESGLCRLEE------VFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLD 97
F S P L++ + L E F + +L+ L+L N ++P D +L L L
Sbjct: 105 FGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLT-KLQILS 163
Query: 98 LRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTL---KALNLRHCPLEFPPQ 154
LR N + +LP IG LK L ++ N + +LP ELG++ + + P P
Sbjct: 164 LRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIA 223
Query: 155 LVVQKGLVAIQRFLRMWAVEHSLPRNPTSQEAPP 188
Q G+ + ++R ++ R+ + PP
Sbjct: 224 DQFQLGVSHVFEYIRSETYKYLYGRHMQANPEPP 257
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 52.0 bits (123), Expect = 9e-07
Identities = 36/102 (35%), Positives = 52/102 (50%), Gaps = 2/102 (1%)
Query: 61 EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
EE+ + +L+ L+LQ N L I + F QL NL LDL N + +P+ + L L
Sbjct: 145 EEITNLRNLKCLYLQHNELTCISEGFEQL-SNLEDLDLSNNHLTTVPASFSSLSSLVRLN 203
Query: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLE-FPPQLVVQKGL 161
L N +K LP E+ + LK L+ LE PP+L + L
Sbjct: 204 LSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESL 245
Score = 51.2 bits (121), Expect = 2e-06
Identities = 43/149 (28%), Positives = 72/149 (48%), Gaps = 5/149 (3%)
Query: 46 SSPILDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKA 105
S +L L + L L E L++LH+ N + ++ + + L ++ LDLR N++K+
Sbjct: 244 SLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKS 303
Query: 106 LPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQ 165
+P I + L+ L L N I LP LG++ LK L L PL + ++ KG +
Sbjct: 304 VPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVL 362
Query: 166 RFLRMWAVEHSLPRNPTSQEAPPVREMTL 194
++LR + P+ E+ MTL
Sbjct: 363 KYLRSKIKDD----GPSQSESATETAMTL 387
Score = 50.1 bits (118), Expect = 3e-06
Identities = 29/78 (37%), Positives = 47/78 (60%), Gaps = 1/78 (1%)
Query: 69 LQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKM 128
L +L + N L + D +LLP LT LD+ N++ +LPS I ++L+ L + N +K+
Sbjct: 84 LTKLIISNNKLQSLTDDL-RLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKI 142
Query: 129 LPVELGSVTTLKALNLRH 146
LP E+ ++ LK L L+H
Sbjct: 143 LPEEITNLRNLKCLYLQH 160
Score = 44.3 bits (103), Expect = 2e-04
Identities = 40/145 (27%), Positives = 66/145 (45%), Gaps = 26/145 (17%)
Query: 50 LDLSESGLCRLE-EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALP- 107
+DLS + L + E+ + L L L+ N L +P++ L+ L ++L +NR K LP
Sbjct: 454 VDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLV-RLQTINLSFNRFKMLPE 512
Query: 108 ---------------SGIGA--------HQHLKTLLLERNPIKMLPVELGSVTTLKALNL 144
+ +G+ ++L TL L+ N + +P ELG+ L+ L L
Sbjct: 513 VLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLL 572
Query: 145 RHCPLEFPPQLVVQKGLVAIQRFLR 169
P P ++ KG AI +LR
Sbjct: 573 DGNPFRVPRAAILMKGTAAILEYLR 597
Score = 40.8 bits (94), Expect = 0.002
Identities = 29/112 (25%), Positives = 56/112 (50%), Gaps = 4/112 (3%)
Query: 49 ILDLSESGLCRL-EEVF---RIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIK 104
ILD S+ + +EVF + + ++ +N LC IP+ +L ++ +DL +N++
Sbjct: 403 ILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLS 462
Query: 105 ALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLV 156
+ + Q L L L N + LP E+ S+ L+ +NL + P+++
Sbjct: 463 FISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVL 514
Score = 40.4 bits (93), Expect = 0.003
Identities = 31/102 (30%), Positives = 52/102 (50%), Gaps = 3/102 (2%)
Query: 50 LDLSESGLCRLEEVFR-IPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
LDLS + L + F + SL +L+L N L +P + ++ L LD N ++ +P
Sbjct: 179 LDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRM-KRLKHLDCNSNLLETIPP 237
Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLE 150
+ + L+ L L RN ++ LP E S + LK L++ +E
Sbjct: 238 ELAGMESLELLYLRRNKLRFLP-EFPSCSLLKELHVGENQIE 278
Score = 38.5 bits (88), Expect = 0.010
Identities = 30/97 (30%), Positives = 52/97 (53%), Gaps = 7/97 (7%)
Query: 50 LDLSESGLCRLEEVFRIPSLQQL----HLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKA 105
++ S++ LC + + R+ L+++ L N L I + +L LT+LDLR N + +
Sbjct: 430 INFSKNQLCEIPK--RMVELKEMVSDVDLSFNKLSFISLELC-VLQKLTFLDLRNNFLNS 486
Query: 106 LPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKAL 142
LP + + L+T+ L N KMLP L + TL+ +
Sbjct: 487 LPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETI 523
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 51.2 bits (121), Expect = 2e-06
Identities = 31/82 (37%), Positives = 43/82 (52%), Gaps = 1/82 (1%)
Query: 63 VFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLE 122
+ ++ LQ+ L R L IP+ F NL LDL N I +P GIG L+ L+L
Sbjct: 79 LLKLNQLQEWQLHRTGLLKIPE-FIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILS 137
Query: 123 RNPIKMLPVELGSVTTLKALNL 144
N IK +P EL + +L+ L L
Sbjct: 138 YNKIKTVPKELSNCASLEKLEL 159
Score = 48.5 bits (114), Expect = 1e-05
Identities = 33/98 (33%), Positives = 49/98 (50%), Gaps = 2/98 (2%)
Query: 57 LCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQH 115
+C L +E+ + L L L N IP + P L WLD+ N+++ LP I Q+
Sbjct: 165 ICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNM-PALEWLDMGSNKLEQLPDTIERMQN 223
Query: 116 LKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPP 153
L TL L+RN I LP + ++ L L L + L+ P
Sbjct: 224 LHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIP 261
Score = 48.5 bits (114), Expect = 1e-05
Identities = 35/112 (31%), Positives = 57/112 (50%), Gaps = 2/112 (1%)
Query: 50 LDLSESGLCRLE-EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
LDLS + + V +P+L+ L + N L +P D + + NL L L+ N I LP
Sbjct: 181 LDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLP-DTIERMQNLHTLWLQRNEITCLPQ 239
Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKG 160
I ++L TL+L N ++ +PV + + L+ +N R PL+ L +G
Sbjct: 240 TISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEG 291
Score = 37.4 bits (85), Expect = 0.023
Identities = 34/95 (35%), Positives = 47/95 (49%), Gaps = 3/95 (3%)
Query: 52 LSESGLCRLEE-VFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGI 110
L +GL ++ E + R +L L L RN + IP LL L L L YN+IK +P +
Sbjct: 90 LHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGI-GLLTRLQELILSYNKIKTVPKEL 148
Query: 111 GAHQHLKTLLLERN-PIKMLPVELGSVTTLKALNL 144
L+ L L N I LP EL ++ L L+L
Sbjct: 149 SNCASLEKLELAVNRDICDLPQELSNLLKLTHLDL 183
>gi|40254924 leucine rich repeat containing 59 [Homo sapiens]
Length = 307
Score = 50.4 bits (119), Expect = 3e-06
Identities = 34/101 (33%), Positives = 52/101 (51%), Gaps = 1/101 (0%)
Query: 50 LDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSG 109
L LS+ ++E+ +P L L N L +P DF L +L LDL N+++ LP+
Sbjct: 22 LSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLT-HLVKLDLSKNKLQQLPAD 80
Query: 110 IGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLE 150
G +L+ L L N + LPV + LK L+L+ PL+
Sbjct: 81 FGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLD 121
Score = 43.1 bits (100), Expect = 4e-04
Identities = 25/74 (33%), Positives = 37/74 (50%)
Query: 71 QLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLP 130
+L L + L +P LP T LDL N++ LPS HL L L +N ++ LP
Sbjct: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
Query: 131 VELGSVTTLKALNL 144
+ G + L+ L+L
Sbjct: 79 ADFGRLVNLQHLDL 92
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,880,115
Number of Sequences: 37866
Number of extensions: 847976
Number of successful extensions: 3851
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 179
Number of HSP's successfully gapped in prelim test: 82
Number of HSP's that attempted gapping in prelim test: 2942
Number of HSP's gapped (non-prelim): 761
length of query: 383
length of database: 18,247,518
effective HSP length: 104
effective length of query: 279
effective length of database: 14,309,454
effective search space: 3992337666
effective search space used: 3992337666
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.