Search of human proteins with 219555700

Search of human proteins with 219555700

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|219555700 leucine rich repeat containing 27 isoform a [Homo
sapiens]
         (530 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|219555700 leucine rich repeat containing 27 isoform a [Homo s...  1041   0.0  
gi|55741567 leucine rich repeat containing 27 isoform a [Homo sa...  1041   0.0  
gi|219555702 leucine rich repeat containing 27 isoform b [Homo s...   707   0.0  
gi|219555704 leucine rich repeat containing 27 isoform c [Homo s...   619   e-177
gi|53729363 leucine rich repeat and sterile alpha motif containi...    76   7e-14
gi|53729361 leucine rich repeat and sterile alpha motif containi...    76   7e-14
gi|53729359 leucine rich repeat and sterile alpha motif containi...    76   7e-14
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom...    70   6e-12
gi|28872863 CCR4-NOT transcription complex, subunit 6 [Homo sapi...    59   1e-08
gi|115583679 CCR4-NOT transcription complex, subunit 6-like [Hom...    59   1e-08
gi|167466264 leucine rich repeat containing 18 [Homo sapiens]          57   5e-08
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]           57   5e-08
gi|61742786 leucine rich repeat and death domain containing prot...    55   1e-07
gi|61742784 leucine rich repeat and death domain containing prot...    55   1e-07
gi|33285015 leucine rich repeat containing 28 [Homo sapiens]           55   1e-07
gi|4503743 flightless I homolog [Homo sapiens]                         54   5e-07
gi|197333692 leucine rich repeat containing 8 family, member B [...    54   5e-07
gi|21245134 leucine rich repeat containing 8 family, member B [H...    54   5e-07
gi|62241040 leucine rich repeat containing 8 family, member A [H...    53   6e-07
gi|187829877 leucine rich repeat containing 8 family, member A [...    53   6e-07
gi|187829871 leucine rich repeat containing 8 family, member A [...    53   6e-07
gi|95113664 leucine rich repeat containing 1 [Homo sapiens]            53   6e-07
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]         52   1e-06
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]          52   1e-06
gi|193788651 leucine rich repeat containing 69 [Homo sapiens]          52   1e-06
gi|61742782 leucine rich repeat and death domain containing prot...    52   1e-06
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]           52   1e-06
gi|21361633 leucine rich repeat containing 40 [Homo sapiens]           52   1e-06
gi|21389431 leucine rich repeat containing 39 [Homo sapiens]           51   2e-06
gi|40254924 leucine rich repeat containing 59 [Homo sapiens]           50   4e-06

>gi|219555700 leucine rich repeat containing 27 isoform a [Homo
           sapiens]
          Length = 530

 Score = 1041 bits (2691), Expect = 0.0
 Identities = 530/530 (100%), Positives = 530/530 (100%)

Query: 1   MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRL 60
           MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRL
Sbjct: 1   MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRL 60

Query: 61  EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
           EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL
Sbjct: 61  EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120

Query: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRN 180
           LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRN
Sbjct: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRN 180

Query: 181 PTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDL 240
           PTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDL
Sbjct: 181 PTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDL 240

Query: 241 SELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKE 300
           SELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKE
Sbjct: 241 SELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKE 300

Query: 301 LPKPRHVFRRKTASSRSILPDLLSPYQMAIRAKRLEESRAAALRELQEKQALMEQQRREK 360
           LPKPRHVFRRKTASSRSILPDLLSPYQMAIRAKRLEESRAAALRELQEKQALMEQQRREK
Sbjct: 301 LPKPRHVFRRKTASSRSILPDLLSPYQMAIRAKRLEESRAAALRELQEKQALMEQQRREK 360

Query: 361 RALQEWRERAQRMRKRKEELSKLLPPRRSMVASKIPSATDLIDNRKVPLNPPGKMKPSKE 420
           RALQEWRERAQRMRKRKEELSKLLPPRRSMVASKIPSATDLIDNRKVPLNPPGKMKPSKE
Sbjct: 361 RALQEWRERAQRMRKRKEELSKLLPPRRSMVASKIPSATDLIDNRKVPLNPPGKMKPSKE 420

Query: 421 KSPQASKEMSALQERNLEEKIKQHVLQMREQRRFHGQAPLEEMRKAAEDLEIATELQDEV 480
           KSPQASKEMSALQERNLEEKIKQHVLQMREQRRFHGQAPLEEMRKAAEDLEIATELQDEV
Sbjct: 421 KSPQASKEMSALQERNLEEKIKQHVLQMREQRRFHGQAPLEEMRKAAEDLEIATELQDEV 480

Query: 481 LKLKLGLTLNKDRRRAALTGNLSLGLPAAQPQNTFFNTKYGESGNVRRYQ 530
           LKLKLGLTLNKDRRRAALTGNLSLGLPAAQPQNTFFNTKYGESGNVRRYQ
Sbjct: 481 LKLKLGLTLNKDRRRAALTGNLSLGLPAAQPQNTFFNTKYGESGNVRRYQ 530


>gi|55741567 leucine rich repeat containing 27 isoform a [Homo
           sapiens]
          Length = 530

 Score = 1041 bits (2691), Expect = 0.0
 Identities = 530/530 (100%), Positives = 530/530 (100%)

Query: 1   MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRL 60
           MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRL
Sbjct: 1   MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRL 60

Query: 61  EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
           EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL
Sbjct: 61  EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120

Query: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRN 180
           LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRN
Sbjct: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRN 180

Query: 181 PTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDL 240
           PTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDL
Sbjct: 181 PTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDL 240

Query: 241 SELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKE 300
           SELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKE
Sbjct: 241 SELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKE 300

Query: 301 LPKPRHVFRRKTASSRSILPDLLSPYQMAIRAKRLEESRAAALRELQEKQALMEQQRREK 360
           LPKPRHVFRRKTASSRSILPDLLSPYQMAIRAKRLEESRAAALRELQEKQALMEQQRREK
Sbjct: 301 LPKPRHVFRRKTASSRSILPDLLSPYQMAIRAKRLEESRAAALRELQEKQALMEQQRREK 360

Query: 361 RALQEWRERAQRMRKRKEELSKLLPPRRSMVASKIPSATDLIDNRKVPLNPPGKMKPSKE 420
           RALQEWRERAQRMRKRKEELSKLLPPRRSMVASKIPSATDLIDNRKVPLNPPGKMKPSKE
Sbjct: 361 RALQEWRERAQRMRKRKEELSKLLPPRRSMVASKIPSATDLIDNRKVPLNPPGKMKPSKE 420

Query: 421 KSPQASKEMSALQERNLEEKIKQHVLQMREQRRFHGQAPLEEMRKAAEDLEIATELQDEV 480
           KSPQASKEMSALQERNLEEKIKQHVLQMREQRRFHGQAPLEEMRKAAEDLEIATELQDEV
Sbjct: 421 KSPQASKEMSALQERNLEEKIKQHVLQMREQRRFHGQAPLEEMRKAAEDLEIATELQDEV 480

Query: 481 LKLKLGLTLNKDRRRAALTGNLSLGLPAAQPQNTFFNTKYGESGNVRRYQ 530
           LKLKLGLTLNKDRRRAALTGNLSLGLPAAQPQNTFFNTKYGESGNVRRYQ
Sbjct: 481 LKLKLGLTLNKDRRRAALTGNLSLGLPAAQPQNTFFNTKYGESGNVRRYQ 530


>gi|219555702 leucine rich repeat containing 27 isoform b [Homo
           sapiens]
          Length = 383

 Score =  707 bits (1824), Expect = 0.0
 Identities = 358/358 (100%), Positives = 358/358 (100%)

Query: 1   MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRL 60
           MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRL
Sbjct: 1   MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRL 60

Query: 61  EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
           EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL
Sbjct: 61  EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120

Query: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRN 180
           LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRN
Sbjct: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRN 180

Query: 181 PTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDL 240
           PTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDL
Sbjct: 181 PTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDL 240

Query: 241 SELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKE 300
           SELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKE
Sbjct: 241 SELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKE 300

Query: 301 LPKPRHVFRRKTASSRSILPDLLSPYQMAIRAKRLEESRAAALRELQEKQALMEQQRR 358
           LPKPRHVFRRKTASSRSILPDLLSPYQMAIRAKRLEESRAAALRELQEKQALMEQQRR
Sbjct: 301 LPKPRHVFRRKTASSRSILPDLLSPYQMAIRAKRLEESRAAALRELQEKQALMEQQRR 358


>gi|219555704 leucine rich repeat containing 27 isoform c [Homo
           sapiens]
          Length = 383

 Score =  619 bits (1596), Expect = e-177
 Identities = 309/318 (97%), Positives = 313/318 (98%)

Query: 1   MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRL 60
           MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRL
Sbjct: 1   MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRL 60

Query: 61  EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
           EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL
Sbjct: 61  EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120

Query: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRN 180
           LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRN
Sbjct: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRN 180

Query: 181 PTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDL 240
           PTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDL
Sbjct: 181 PTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDL 240

Query: 241 SELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKE 300
           SELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKE
Sbjct: 241 SELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKE 300

Query: 301 LPKPRHVFRRKTASSRSI 318
           LPKPRHVFR +    +++
Sbjct: 301 LPKPRHVFRTRVPRKQAL 318


>gi|53729363 leucine rich repeat and sterile alpha motif containing
           1 [Homo sapiens]
          Length = 723

 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 110/479 (22%), Positives = 203/479 (42%), Gaps = 66/479 (13%)

Query: 49  ILDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALP 107
           +LDL ++ L  L +++ ++ +LQ L+++RN L  +P+    L   L  L+++ N++K LP
Sbjct: 85  VLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLT-QLQTLNVKDNKLKELP 143

Query: 108 SGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRF 167
             +G  + L+TL +  N I+ LP  L  V TL+ L+L    + +PP+ V   G  AI +F
Sbjct: 144 DTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQF 203

Query: 168 LRMWAVEHSLPRNPTSQEAPPVREM----TLRDLP-SPGLELSGDHASNQGAVNAQDP-E 221
           L     E  L   P SQ   P+ E       RD P  P    S +    Q   +  +  +
Sbjct: 204 L---CKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTDRFSREELEWQNRFSDYEKRK 260

Query: 222 GAVMKEKASFLPPVE----------------KPDLSELRKSADSSENWPSEEEIRRFWKL 265
              M EK  F   +E                K ++ +  K   S       E  R     
Sbjct: 261 EQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAE 320

Query: 266 RQEIVEHVK----------ADVLGDQLLTRELPPNLKAALNIEKELPKPRHVFRRKTASS 315
           RQ + E +K            +L D    ++    LK+  N    + +   + + +T S 
Sbjct: 321 RQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLENERIRMEQLMSITQEETESL 380

Query: 316 R-----SILPDLLSP------YQMAIRAKR--LEESRAAALRELQEK--QALMEQQRREK 360
           R     S +  +L+        QMA  ++R  L +   +++ E+ E+  Q L  QQ  + 
Sbjct: 381 RRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSSMAEMDERFQQILSWQQMDQN 440

Query: 361 RALQEWRERAQRMRKRKEELSKLLPPRRSMVASKIPSATDLIDNRKVPLNPPGKMKPSKE 420
           +A+ +  + +   +   E L      ++ ++  +I S   LI+   + L    +++  ++
Sbjct: 441 KAISQILQESAMQKAAFEALQ----VKKDLMHRQIRSQIKLIETELLQLT---QLELKRK 493

Query: 421 KSPQASKEMSALQERNLEEKIKQHVLQMREQRRFHGQAPLEEMRKAAEDLEIATELQDE 479
                S +    ++R     + Q +L+ ++QR        EE+R+   +LE  +E + E
Sbjct: 494 SLDTESLQEMISEQRWALSSLLQQLLKEKQQRE-------EELREILTELEAKSETRQE 545



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 102/462 (22%), Positives = 192/462 (41%), Gaps = 40/462 (8%)

Query: 49  ILDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLLPN---------LTWLDLR 99
           ILD+S+   C L E+          LQ+  L V       LLP          +  LDL 
Sbjct: 33  ILDISK---CELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLH 89

Query: 100 YNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQK 159
            N++ ALP  +G    L+ L +ERN +  LP  +G++T L+ LN++   L+  P  V   
Sbjct: 90  DNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTV--- 146

Query: 160 GLVAIQRFLRMWAVE-HSLPRNPTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQ 218
           G +   R L +   E   LP+         +  +    +  P  E+ G   +       +
Sbjct: 147 GELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQFLCK 206

Query: 219 DPEGAVMKEKASFLPPVEKPDLSELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVL 278
           +            LP +E+  +   R S D   +  S EE+   W+ R    E  K   +
Sbjct: 207 ESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTDRFSREELE--WQNRFSDYEKRKEQKM 264

Query: 279 GDQL-LTRELPPNLKAALNIEKELPKPRHVFRRKTASSRSILPDLLSPYQMAIRA--KRL 335
            ++L   R L    +    + ++    +    +     +S L   LS +Q  + A  +RL
Sbjct: 265 LEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRL 324

Query: 336 EESRAAALRELQEK-QALMEQQRREK------RALQEWRERAQRMRKRKEELSKLLPPRR 388
           +E      + +  + Q L++  +R+K      ++L+  R R +++    +E ++ L  RR
Sbjct: 325 QEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLENERIRMEQLMSITQEETESL-RRR 383

Query: 389 SMVASKIPSATDLIDNRKVPLNPPGKMKPSKEKSPQASKEMSALQERNLEEKIKQHV-LQ 447
            + ++     T+   NR +      +M    ++     +  S++ E  ++E+ +Q +  Q
Sbjct: 384 DVASAMQQMLTESCKNRLI------QMAYESQRQNLVQQACSSMAE--MDERFQQILSWQ 435

Query: 448 MREQRRFHGQAPLEE-MRKAA-EDLEIATELQDEVLKLKLGL 487
             +Q +   Q   E  M+KAA E L++  +L    ++ ++ L
Sbjct: 436 QMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKL 477


>gi|53729361 leucine rich repeat and sterile alpha motif containing
           1 [Homo sapiens]
          Length = 723

 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 110/479 (22%), Positives = 203/479 (42%), Gaps = 66/479 (13%)

Query: 49  ILDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALP 107
           +LDL ++ L  L +++ ++ +LQ L+++RN L  +P+    L   L  L+++ N++K LP
Sbjct: 85  VLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLT-QLQTLNVKDNKLKELP 143

Query: 108 SGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRF 167
             +G  + L+TL +  N I+ LP  L  V TL+ L+L    + +PP+ V   G  AI +F
Sbjct: 144 DTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQF 203

Query: 168 LRMWAVEHSLPRNPTSQEAPPVREM----TLRDLP-SPGLELSGDHASNQGAVNAQDP-E 221
           L     E  L   P SQ   P+ E       RD P  P    S +    Q   +  +  +
Sbjct: 204 L---CKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTDRFSREELEWQNRFSDYEKRK 260

Query: 222 GAVMKEKASFLPPVE----------------KPDLSELRKSADSSENWPSEEEIRRFWKL 265
              M EK  F   +E                K ++ +  K   S       E  R     
Sbjct: 261 EQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAE 320

Query: 266 RQEIVEHVK----------ADVLGDQLLTRELPPNLKAALNIEKELPKPRHVFRRKTASS 315
           RQ + E +K            +L D    ++    LK+  N    + +   + + +T S 
Sbjct: 321 RQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLENERIRMEQLMSITQEETESL 380

Query: 316 R-----SILPDLLSP------YQMAIRAKR--LEESRAAALRELQEK--QALMEQQRREK 360
           R     S +  +L+        QMA  ++R  L +   +++ E+ E+  Q L  QQ  + 
Sbjct: 381 RRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSSMAEMDERFQQILSWQQMDQN 440

Query: 361 RALQEWRERAQRMRKRKEELSKLLPPRRSMVASKIPSATDLIDNRKVPLNPPGKMKPSKE 420
           +A+ +  + +   +   E L      ++ ++  +I S   LI+   + L    +++  ++
Sbjct: 441 KAISQILQESAMQKAAFEALQ----VKKDLMHRQIRSQIKLIETELLQLT---QLELKRK 493

Query: 421 KSPQASKEMSALQERNLEEKIKQHVLQMREQRRFHGQAPLEEMRKAAEDLEIATELQDE 479
                S +    ++R     + Q +L+ ++QR        EE+R+   +LE  +E + E
Sbjct: 494 SLDTESLQEMISEQRWALSSLLQQLLKEKQQRE-------EELREILTELEAKSETRQE 545



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 102/462 (22%), Positives = 192/462 (41%), Gaps = 40/462 (8%)

Query: 49  ILDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLLPN---------LTWLDLR 99
           ILD+S+   C L E+          LQ+  L V       LLP          +  LDL 
Sbjct: 33  ILDISK---CELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLH 89

Query: 100 YNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQK 159
            N++ ALP  +G    L+ L +ERN +  LP  +G++T L+ LN++   L+  P  V   
Sbjct: 90  DNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTV--- 146

Query: 160 GLVAIQRFLRMWAVE-HSLPRNPTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQ 218
           G +   R L +   E   LP+         +  +    +  P  E+ G   +       +
Sbjct: 147 GELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQFLCK 206

Query: 219 DPEGAVMKEKASFLPPVEKPDLSELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVL 278
           +            LP +E+  +   R S D   +  S EE+   W+ R    E  K   +
Sbjct: 207 ESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTDRFSREELE--WQNRFSDYEKRKEQKM 264

Query: 279 GDQL-LTRELPPNLKAALNIEKELPKPRHVFRRKTASSRSILPDLLSPYQMAIRA--KRL 335
            ++L   R L    +    + ++    +    +     +S L   LS +Q  + A  +RL
Sbjct: 265 LEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRL 324

Query: 336 EESRAAALRELQEK-QALMEQQRREK------RALQEWRERAQRMRKRKEELSKLLPPRR 388
           +E      + +  + Q L++  +R+K      ++L+  R R +++    +E ++ L  RR
Sbjct: 325 QEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLENERIRMEQLMSITQEETESL-RRR 383

Query: 389 SMVASKIPSATDLIDNRKVPLNPPGKMKPSKEKSPQASKEMSALQERNLEEKIKQHV-LQ 447
            + ++     T+   NR +      +M    ++     +  S++ E  ++E+ +Q +  Q
Sbjct: 384 DVASAMQQMLTESCKNRLI------QMAYESQRQNLVQQACSSMAE--MDERFQQILSWQ 435

Query: 448 MREQRRFHGQAPLEE-MRKAA-EDLEIATELQDEVLKLKLGL 487
             +Q +   Q   E  M+KAA E L++  +L    ++ ++ L
Sbjct: 436 QMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKL 477


>gi|53729359 leucine rich repeat and sterile alpha motif containing
           1 [Homo sapiens]
          Length = 723

 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 110/479 (22%), Positives = 203/479 (42%), Gaps = 66/479 (13%)

Query: 49  ILDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALP 107
           +LDL ++ L  L +++ ++ +LQ L+++RN L  +P+    L   L  L+++ N++K LP
Sbjct: 85  VLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLT-QLQTLNVKDNKLKELP 143

Query: 108 SGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRF 167
             +G  + L+TL +  N I+ LP  L  V TL+ L+L    + +PP+ V   G  AI +F
Sbjct: 144 DTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQF 203

Query: 168 LRMWAVEHSLPRNPTSQEAPPVREM----TLRDLP-SPGLELSGDHASNQGAVNAQDP-E 221
           L     E  L   P SQ   P+ E       RD P  P    S +    Q   +  +  +
Sbjct: 204 L---CKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTDRFSREELEWQNRFSDYEKRK 260

Query: 222 GAVMKEKASFLPPVE----------------KPDLSELRKSADSSENWPSEEEIRRFWKL 265
              M EK  F   +E                K ++ +  K   S       E  R     
Sbjct: 261 EQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAE 320

Query: 266 RQEIVEHVK----------ADVLGDQLLTRELPPNLKAALNIEKELPKPRHVFRRKTASS 315
           RQ + E +K            +L D    ++    LK+  N    + +   + + +T S 
Sbjct: 321 RQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLENERIRMEQLMSITQEETESL 380

Query: 316 R-----SILPDLLSP------YQMAIRAKR--LEESRAAALRELQEK--QALMEQQRREK 360
           R     S +  +L+        QMA  ++R  L +   +++ E+ E+  Q L  QQ  + 
Sbjct: 381 RRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSSMAEMDERFQQILSWQQMDQN 440

Query: 361 RALQEWRERAQRMRKRKEELSKLLPPRRSMVASKIPSATDLIDNRKVPLNPPGKMKPSKE 420
           +A+ +  + +   +   E L      ++ ++  +I S   LI+   + L    +++  ++
Sbjct: 441 KAISQILQESAMQKAAFEALQ----VKKDLMHRQIRSQIKLIETELLQLT---QLELKRK 493

Query: 421 KSPQASKEMSALQERNLEEKIKQHVLQMREQRRFHGQAPLEEMRKAAEDLEIATELQDE 479
                S +    ++R     + Q +L+ ++QR        EE+R+   +LE  +E + E
Sbjct: 494 SLDTESLQEMISEQRWALSSLLQQLLKEKQQRE-------EELREILTELEAKSETRQE 545



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 102/462 (22%), Positives = 192/462 (41%), Gaps = 40/462 (8%)

Query: 49  ILDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLLPN---------LTWLDLR 99
           ILD+S+   C L E+          LQ+  L V       LLP          +  LDL 
Sbjct: 33  ILDISK---CELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLH 89

Query: 100 YNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQK 159
            N++ ALP  +G    L+ L +ERN +  LP  +G++T L+ LN++   L+  P  V   
Sbjct: 90  DNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTV--- 146

Query: 160 GLVAIQRFLRMWAVE-HSLPRNPTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQ 218
           G +   R L +   E   LP+         +  +    +  P  E+ G   +       +
Sbjct: 147 GELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQFLCK 206

Query: 219 DPEGAVMKEKASFLPPVEKPDLSELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVL 278
           +            LP +E+  +   R S D   +  S EE+   W+ R    E  K   +
Sbjct: 207 ESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTDRFSREELE--WQNRFSDYEKRKEQKM 264

Query: 279 GDQL-LTRELPPNLKAALNIEKELPKPRHVFRRKTASSRSILPDLLSPYQMAIRA--KRL 335
            ++L   R L    +    + ++    +    +     +S L   LS +Q  + A  +RL
Sbjct: 265 LEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRL 324

Query: 336 EESRAAALRELQEK-QALMEQQRREK------RALQEWRERAQRMRKRKEELSKLLPPRR 388
           +E      + +  + Q L++  +R+K      ++L+  R R +++    +E ++ L  RR
Sbjct: 325 QEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLENERIRMEQLMSITQEETESL-RRR 383

Query: 389 SMVASKIPSATDLIDNRKVPLNPPGKMKPSKEKSPQASKEMSALQERNLEEKIKQHV-LQ 447
            + ++     T+   NR +      +M    ++     +  S++ E  ++E+ +Q +  Q
Sbjct: 384 DVASAMQQMLTESCKNRLI------QMAYESQRQNLVQQACSSMAE--MDERFQQILSWQ 435

Query: 448 MREQRRFHGQAPLEE-MRKAA-EDLEIATELQDEVLKLKLGL 487
             +Q +   Q   E  M+KAA E L++  +L    ++ ++ L
Sbjct: 436 QMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKL 477


>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
           sapiens]
          Length = 560

 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 42/109 (38%), Positives = 62/109 (56%), Gaps = 1/109 (0%)

Query: 61  EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
           E + ++ SL++L+++ N L  +P     + PNL  LD R+N +K LP  I   Q LK L 
Sbjct: 392 EHIRKLQSLKELYIENNHLEYLPVSLGSM-PNLEVLDCRHNLLKQLPDAICQAQALKELR 450

Query: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLR 169
           LE N +  LP  L S+  LK L L   P+E PP+ V  +G  AI ++L+
Sbjct: 451 LEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLK 499



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 45/128 (35%), Positives = 67/128 (52%), Gaps = 8/128 (6%)

Query: 36  HKGVGGIIFSSSPILDLSESGLC--RLEEVFRI----PSLQQLHLQRNALCVIPQDFFQL 89
           H  +  I  S + +  ++E GL   RLE+V R+     SL  L+L    L  + +  F+ 
Sbjct: 243 HNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRL-RGSFRC 301

Query: 90  LPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCP- 148
           L NL +LDL  N +   P  I A ++L+ L L+ N I  LP ELGS++ LK L L     
Sbjct: 302 LVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEF 361

Query: 149 LEFPPQLV 156
           L FP +++
Sbjct: 362 LSFPEEVL 369



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 42/143 (29%), Positives = 70/143 (48%), Gaps = 7/143 (4%)

Query: 43  IFSSSPILDLSESGL--CRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRY 100
           + SS   LDLS + +    L  V  + +L++L L +  L  IP   F+ L +L  L L  
Sbjct: 92  LLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTG 151

Query: 101 NRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKG 160
           N +K LP  I     L+ + L+RN  ++ P EL  + TL+ ++L    +   P+ +    
Sbjct: 152 NHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGH-- 209

Query: 161 LVAIQRFLRMWAVEHSLPRNPTS 183
           L  +Q+F   +   ++LP  P S
Sbjct: 210 LTGLQKF---YMASNNLPVLPAS 229



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 30/97 (30%), Positives = 49/97 (50%), Gaps = 1/97 (1%)

Query: 58  CRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLK 117
           C  +E+     L++++L+RN   V PQ+   +L  L  +DL  N+I A+P  IG    L+
Sbjct: 156 CLPKEIVNQTKLREIYLKRNQFEVFPQELC-VLYTLEIIDLDENKIGAIPEEIGHLTGLQ 214

Query: 118 TLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQ 154
              +  N + +LP  L   + L  L+L H  L   P+
Sbjct: 215 KFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPK 251



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 26/78 (33%), Positives = 42/78 (53%), Gaps = 2/78 (2%)

Query: 50  LDLSESGLCRLE-EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
           +D S   L  +  E+F    L+++HL+ N +  IPQ+  Q L N+  L L  N +++L  
Sbjct: 30  IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQE-IQRLKNIRVLYLDKNNLRSLCP 88

Query: 109 GIGAHQHLKTLLLERNPI 126
            +G    L++L L  NPI
Sbjct: 89  ALGLLSSLESLDLSYNPI 106



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 36/100 (36%), Positives = 51/100 (51%), Gaps = 2/100 (2%)

Query: 44  FSSSPILDLSESGLCRLEEVFR-IPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNR 102
           ++S  +L L  +GL RL   FR + +L+ L L +N L   P     L  NL  L L  N+
Sbjct: 279 WTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICAL-KNLEVLGLDDNK 337

Query: 103 IKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKAL 142
           I  LPS +G+   LK L L  N     P E+ S+ +L+ L
Sbjct: 338 IGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKL 377



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 33/113 (29%), Positives = 55/113 (48%), Gaps = 3/113 (2%)

Query: 49  ILDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQL--LPNLTWLDLRYNRIKA 105
           +L L ++ + +L  E+  +  L+ L L  N     P++   L  L  L     +  ++  
Sbjct: 330 VLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTY 389

Query: 106 LPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQ 158
           +P  I   Q LK L +E N ++ LPV LGS+  L+ L+ RH  L+  P  + Q
Sbjct: 390 VPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQ 442


>gi|28872863 CCR4-NOT transcription complex, subunit 6 [Homo
           sapiens]
          Length = 557

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 34/87 (39%), Positives = 52/87 (59%), Gaps = 1/87 (1%)

Query: 63  VFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLE 122
           ++ +  L  LHL  N+L  IP D  +L  NL +LDL  N+I++LP+ +G    L+ L L 
Sbjct: 47  LWSLTHLTALHLSDNSLSRIPSDIAKL-HNLVYLDLSSNKIRSLPAELGNMVSLRELHLN 105

Query: 123 RNPIKMLPVELGSVTTLKALNLRHCPL 149
            N +++LP ELG +  L+ L L+  PL
Sbjct: 106 NNLLRVLPFELGKLFQLQTLGLKGNPL 132



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 24/64 (37%), Positives = 35/64 (54%)

Query: 90  LPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPL 149
           L +LT L L  N +  +PS I    +L  L L  N I+ LP ELG++ +L+ L+L +  L
Sbjct: 50  LTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLL 109

Query: 150 EFPP 153
              P
Sbjct: 110 RVLP 113


>gi|115583679 CCR4-NOT transcription complex, subunit 6-like [Homo
           sapiens]
          Length = 555

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 34/87 (39%), Positives = 52/87 (59%), Gaps = 1/87 (1%)

Query: 63  VFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLE 122
           ++ +  L  LHL  N L  IP D  +L  NL +LDL  N++++LP+ +G    L+ LLL 
Sbjct: 52  LWSLTHLTALHLNDNYLSRIPPDIAKL-HNLVYLDLSSNKLRSLPAELGNMVSLRELLLN 110

Query: 123 RNPIKMLPVELGSVTTLKALNLRHCPL 149
            N +++LP ELG +  L+ L L+  PL
Sbjct: 111 NNLLRVLPYELGRLFQLQTLGLKGNPL 137



 Score = 35.0 bits (79), Expect = 0.17
 Identities = 22/64 (34%), Positives = 33/64 (51%)

Query: 90  LPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPL 149
           L +LT L L  N +  +P  I    +L  L L  N ++ LP ELG++ +L+ L L +  L
Sbjct: 55  LTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLL 114

Query: 150 EFPP 153
              P
Sbjct: 115 RVLP 118


>gi|167466264 leucine rich repeat containing 18 [Homo sapiens]
          Length = 261

 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 48/163 (29%), Positives = 75/163 (46%), Gaps = 10/163 (6%)

Query: 42  IIFSSSPILDLSESGLCRLEE-VFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRY 100
           I F     LDLS+ G+    + + R+  + +L L RN +  IP D      NL WLDL  
Sbjct: 24  ITFDGKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIP-DSISKFQNLRWLDLHS 82

Query: 101 NRIKALPSGIGAHQHLKTLLLERNPIKM--LPVELGSVTTLKALNLRHCPLEFPPQLVVQ 158
           N I  LP  IG    L  L +  N +    LPVEL  +  ++A+NL    L+  P     
Sbjct: 83  NYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTT--- 139

Query: 159 KGLVAIQRFLRMWAVEHSLPRNPTS-QEAPPVREMTLRDLPSP 200
             L A++    +   ++ L   P S  + P ++++ ++  P P
Sbjct: 140 --LGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFP 180



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 35/128 (27%), Positives = 67/128 (52%), Gaps = 6/128 (4%)

Query: 50  LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCV--IPQDFFQLLPNLTWLDLRYNRIKAL 106
           LDL  + + +L E + ++ SL  L++  N L    +P +  QL  N+  ++L  N + ++
Sbjct: 78  LDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQL-KNIRAVNLGLNHLDSV 136

Query: 107 PSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQR 166
           P+ +GA + L  + L  N +  +PV +  +  LK LN++  P  FP     +  + +I+R
Sbjct: 137 PTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNP--FPKPGESEIFIDSIRR 194

Query: 167 FLRMWAVE 174
              ++ VE
Sbjct: 195 LENLYVVE 202


>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
          Length = 582

 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 44/140 (31%), Positives = 76/140 (54%), Gaps = 4/140 (2%)

Query: 49  ILDLSESGLCRLEEV-FRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALP 107
           +LDL  + L  +  V +R+ SL  L+L+ N +  + +D  + L  L+ L +R N+IK LP
Sbjct: 173 MLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDI-KNLSKLSMLSIRENKIKQLP 231

Query: 108 SGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCP-LEFPPQLVVQKGLVAI-Q 165
           + IG   +L TL +  N ++ LP E+G+ T +  L+L+H   L+ P  +     L  +  
Sbjct: 232 AEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGL 291

Query: 166 RFLRMWAVEHSLPRNPTSQE 185
           R+ R+ A+  SL +    +E
Sbjct: 292 RYNRLSAIPRSLAKCSALEE 311



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 49/167 (29%), Positives = 79/167 (47%), Gaps = 14/167 (8%)

Query: 52  LSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIG 111
           + E   CR E   R      L L + ++ ++P    +L   LT L L  N++++LP+ +G
Sbjct: 91  IKELNKCREENSMR------LDLSKRSIHILPSSIKELT-QLTELYLYSNKLQSLPAEVG 143

Query: 112 AHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVA--IQRFLR 169
              +L TL L  N +  LP  L ++  L+ L+LRH  L   P +V +   +     RF R
Sbjct: 144 CLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNR 203

Query: 170 MWAVEHSLPRNPTSQEAPPVREMTLRDLPSPGLELSG----DHASNQ 212
           +  VE  + +N +      +RE  ++ LP+   EL      D A NQ
Sbjct: 204 ITTVEKDI-KNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQ 249



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 38/106 (35%), Positives = 55/106 (51%), Gaps = 2/106 (1%)

Query: 50  LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
           L LSE+ L  L + +  +  L+ L L+ N L  IP   ++L  +LT L LR+NRI  +  
Sbjct: 151 LALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRL-DSLTTLYLRFNRITTVEK 209

Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQ 154
            I     L  L +  N IK LP E+G +  L  L++ H  LE  P+
Sbjct: 210 DIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPK 255



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 38/106 (35%), Positives = 55/106 (51%), Gaps = 4/106 (3%)

Query: 50  LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
           LD++ + L  L +E+     +  L LQ N L  +P D    L +L+ L LRYNR+ A+P 
Sbjct: 243 LDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLP-DTIGNLSSLSRLGLRYNRLSAIPR 301

Query: 109 GIGAHQHLKTLLLERNPIKMLPVE-LGSVTTLKALNL-RHCPLEFP 152
            +     L+ L LE N I  LP   L S+  L +L L R+C   +P
Sbjct: 302 SLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYP 347



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 44/161 (27%), Positives = 73/161 (45%), Gaps = 28/161 (17%)

Query: 35  VHKGVGGIIFSSSPILDLSESGLCRLEE-VFRIPSLQQLHLQRNALCVIPQDFFQLLPNL 93
           + + V G++  S  +L LS + L +L   +  +  L++L L+ N L  +P +    L +L
Sbjct: 417 IPEDVSGLV--SLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEI-AYLKDL 473

Query: 94  TWLDLRYNRIKALPSG-----------------------IGAHQHLKTLLLERNP-IKML 129
             L L  N++  LP G                       IG  ++L+ L L  NP +  L
Sbjct: 474 QKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSL 533

Query: 130 PVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRM 170
           P EL   + L  +++ +CPL   P  +V  G   I +FL+M
Sbjct: 534 PFELALCSKLSIMSIENCPLSHLPPQIVAGGPSFIIQFLKM 574



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 31/87 (35%), Positives = 48/87 (55%), Gaps = 1/87 (1%)

Query: 68  SLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIK 127
           S+ +L+L  N L  IP+D   L+ +L  L L  N +K LP G+G  + L+ L LE N ++
Sbjct: 403 SMVELNLATNQLTKIPEDVSGLV-SLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLE 461

Query: 128 MLPVELGSVTTLKALNLRHCPLEFPPQ 154
            LP E+  +  L+ L L +  L   P+
Sbjct: 462 SLPNEIAYLKDLQKLVLTNNQLTTLPR 488



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 32/96 (33%), Positives = 52/96 (54%), Gaps = 2/96 (2%)

Query: 50  LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
           L+L+ + L ++ E+V  + SL+ L L  N L  +P     L   L  LDL  N++++LP+
Sbjct: 407 LNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLR-KLRELDLEENKLESLPN 465

Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNL 144
            I   + L+ L+L  N +  LP  +G +T L  L L
Sbjct: 466 EIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGL 501



 Score = 37.0 bits (84), Expect = 0.045
 Identities = 30/111 (27%), Positives = 53/111 (47%), Gaps = 2/111 (1%)

Query: 45  SSSPILDLSESGLCRLE-EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRI 103
           S   +L + E+ + +L  E+  + +L  L +  N L  +P++       +T LDL++N +
Sbjct: 215 SKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCT-QITNLDLQHNEL 273

Query: 104 KALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQ 154
             LP  IG    L  L L  N +  +P  L   + L+ LNL +  +   P+
Sbjct: 274 LDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPE 324



 Score = 37.0 bits (84), Expect = 0.045
 Identities = 32/123 (26%), Positives = 59/123 (47%), Gaps = 27/123 (21%)

Query: 68  SLQQLHLQRNALCVIPQDF----------------FQLLP--------NLTWLDLRYNRI 103
           +L++L+L+ N +  +P+                  FQL P         +  L++ +NRI
Sbjct: 308 ALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRI 367

Query: 104 KALPSGIGAH-QHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLV 162
             +P GI +  + L  L ++ N +  LP++ G+ T++  LNL    L   P+ V   GLV
Sbjct: 368 NKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDV--SGLV 425

Query: 163 AIQ 165
           +++
Sbjct: 426 SLE 428


>gi|61742786 leucine rich repeat and death domain containing protein
           isoform 3 [Homo sapiens]
          Length = 893

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 57/186 (30%), Positives = 85/186 (45%), Gaps = 10/186 (5%)

Query: 50  LDLSESGLCRLEE-VFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
           LDLS + L  L   V ++  L  L L  N L  +P+     LP LT+L + +NR++ LP 
Sbjct: 130 LDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEAL-GALPALTFLTVTHNRLQTLPP 188

Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLE-FPPQLVVQKGLVAIQRF 167
            +GA   L+ L L +N +  LP E+G + +L  LNL    L+  P  L   + L  +   
Sbjct: 189 ALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLH 248

Query: 168 LRMWA-VEHSLPRNPTSQEAPPVREMTLRDLP-----SPGLELSGDHASNQGAVNAQDPE 221
             + A V   L R P       +R+  LRDLP     +P + L G+            P 
Sbjct: 249 SNLLASVPADLARLPLLTRL-DLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPV 307

Query: 222 GAVMKE 227
            A++ E
Sbjct: 308 AALIPE 313



 Score = 38.9 bits (89), Expect = 0.012
 Identities = 24/67 (35%), Positives = 36/67 (53%), Gaps = 1/67 (1%)

Query: 90  LPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPL 149
           L +L  LDL +N ++ LP+ +   + L  LLL  N +  LP  LG++  L  L + H  L
Sbjct: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183

Query: 150 E-FPPQL 155
           +  PP L
Sbjct: 184 QTLPPAL 190


>gi|61742784 leucine rich repeat and death domain containing protein
           isoform 1 [Homo sapiens]
          Length = 910

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 57/186 (30%), Positives = 85/186 (45%), Gaps = 10/186 (5%)

Query: 50  LDLSESGLCRLEE-VFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
           LDLS + L  L   V ++  L  L L  N L  +P+     LP LT+L + +NR++ LP 
Sbjct: 130 LDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEAL-GALPALTFLTVTHNRLQTLPP 188

Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLE-FPPQLVVQKGLVAIQRF 167
            +GA   L+ L L +N +  LP E+G + +L  LNL    L+  P  L   + L  +   
Sbjct: 189 ALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLH 248

Query: 168 LRMWA-VEHSLPRNPTSQEAPPVREMTLRDLP-----SPGLELSGDHASNQGAVNAQDPE 221
             + A V   L R P       +R+  LRDLP     +P + L G+            P 
Sbjct: 249 SNLLASVPADLARLPLLTRL-DLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPV 307

Query: 222 GAVMKE 227
            A++ E
Sbjct: 308 AALIPE 313



 Score = 38.9 bits (89), Expect = 0.012
 Identities = 24/67 (35%), Positives = 36/67 (53%), Gaps = 1/67 (1%)

Query: 90  LPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPL 149
           L +L  LDL +N ++ LP+ +   + L  LLL  N +  LP  LG++  L  L + H  L
Sbjct: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183

Query: 150 E-FPPQL 155
           +  PP L
Sbjct: 184 QTLPPAL 190


>gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
          Length = 367

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 31/88 (35%), Positives = 54/88 (61%), Gaps = 1/88 (1%)

Query: 69  LQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKM 128
           L++L+++RN+L  +P++  Q LPNL  L L  N I  +P  IG+   L+ L L  N +++
Sbjct: 43  LERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEI 102

Query: 129 LPVELGSVTTLKALNLRHCPLEF-PPQL 155
           +  E+G +  L+ L L +  L+F PP++
Sbjct: 103 VCPEIGRLRALRHLRLANNQLQFLPPEV 130



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 34/124 (27%), Positives = 63/124 (50%), Gaps = 5/124 (4%)

Query: 65  RIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERN 124
           ++P+L +L+L  N + V+P+    L+  L  LDL  N ++ +   IG  + L+ L L  N
Sbjct: 63  KLPNLVELYLHSNNIVVVPEAIGSLV-KLQCLDLSDNALEIVCPEIGRLRALRHLRLANN 121

Query: 125 PIKMLPVELGSVTTLKALNLRHCPLEFPPQ---LVVQKGLVAIQRFLRMWAVEHSLPRNP 181
            ++ LP E+G +  L+ L++    L   P+   + +    + + R  R+W V   L + P
Sbjct: 122 QLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDR-NRLWYVPRHLCQLP 180

Query: 182 TSQE 185
           +  E
Sbjct: 181 SLNE 184



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 32/105 (30%), Positives = 52/105 (49%), Gaps = 2/105 (1%)

Query: 50  LDLSESGL-CRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
           LDLS++ L     E+ R+ +L+ L L  N L  +P +   L   L  LD+  NR+  LP 
Sbjct: 93  LDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDL-KELQTLDISTNRLLTLPE 151

Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPP 153
            +     L+ L ++RN +  +P  L  + +L  L++    L F P
Sbjct: 152 RLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLP 196



 Score = 38.5 bits (88), Expect = 0.015
 Identities = 29/83 (34%), Positives = 45/83 (54%), Gaps = 3/83 (3%)

Query: 50  LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
           LD+S + L  L E +    SLQ L + RN L  +P+   QL P+L  L +  NR+  LP 
Sbjct: 139 LDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQL-PSLNELSMAGNRLAFLPL 197

Query: 109 GIGAHQHLKTLLLERN-PIKMLP 130
            +G  + L+ + ++ N  +K LP
Sbjct: 198 DLGRSRELQYVYVDNNIHLKGLP 220



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 21/73 (28%), Positives = 35/73 (47%), Gaps = 1/73 (1%)

Query: 62  EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLL 121
           EV  +  LQ L +  N L  +P+     L +L +L +  NR+  +P  +     L  L +
Sbjct: 129 EVGDLKELQTLDISTNRLLTLPERLHMCL-SLQYLTVDRNRLWYVPRHLCQLPSLNELSM 187

Query: 122 ERNPIKMLPVELG 134
             N +  LP++LG
Sbjct: 188 AGNRLAFLPLDLG 200


>gi|4503743 flightless I homolog [Homo sapiens]
          Length = 1269

 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 40/125 (32%), Positives = 67/125 (53%), Gaps = 4/125 (3%)

Query: 25  RSLPATPSKDVHKGVGGIIFSSSP--ILDLSESGLCRL-EEVFRIPSLQQLHLQRNALCV 81
           R++ A  +   + GV   IF      +LDLS + L     E+    ++  L+L  N++  
Sbjct: 82  RAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDT 141

Query: 82  IPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPV-ELGSVTTLK 140
           IP   F  L +L +LDL  NR+++LP  +    HL+TL+L  NP+    + +L ++T L+
Sbjct: 142 IPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQ 201

Query: 141 ALNLR 145
            L+LR
Sbjct: 202 TLHLR 206



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 36/130 (27%), Positives = 60/130 (46%), Gaps = 5/130 (3%)

Query: 66  IPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNP 125
           + +L  + L  N L  +P+  + L P+L  L+L  N+I  L   I    H++TL L RN 
Sbjct: 222 LSNLADVDLSCNDLTRVPECLYTL-PSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQ 280

Query: 126 IKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRNPTSQ- 184
           +  LP  +  ++ LK L L    L+F     +  G+  +       A  ++L   P S  
Sbjct: 281 LTSLPSAICKLSKLKKLYLNSNKLDFDG---LPSGIGKLTNLEEFMAANNNLELVPESLC 337

Query: 185 EAPPVREMTL 194
             P +R++ L
Sbjct: 338 RCPKLRKLVL 347



 Score = 37.4 bits (85), Expect = 0.034
 Identities = 28/107 (26%), Positives = 51/107 (47%), Gaps = 4/107 (3%)

Query: 61  EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
           E V  + SL+ L L R  LC +P++    L  L  L + +N +  L   + +   L+ ++
Sbjct: 27  ENVKAMTSLRWLKLNRTGLCYLPEE-LAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIV 85

Query: 121 LERNPIKM--LPVELGSVTTLKALNLRHCPL-EFPPQLVVQKGLVAI 164
              N +K   +P ++  +  L  L+L H  L E P +L   K ++ +
Sbjct: 86  ARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVL 132



 Score = 32.7 bits (73), Expect = 0.84
 Identities = 26/90 (28%), Positives = 43/90 (47%), Gaps = 3/90 (3%)

Query: 69  LQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIK--ALPSGIGAHQHLKTLLLERNPI 126
           ++ L+L RN L  +P    +L   L  L L  N++    LPSGIG   +L+  +   N +
Sbjct: 271 VETLNLSRNQLTSLPSAICKL-SKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNL 329

Query: 127 KMLPVELGSVTTLKALNLRHCPLEFPPQLV 156
           +++P  L     L+ L L    L   P+ +
Sbjct: 330 ELVPESLCRCPKLRKLVLNKNHLVTLPEAI 359


>gi|197333692 leucine rich repeat containing 8 family, member B
           [Homo sapiens]
          Length = 803

 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 5/102 (4%)

Query: 58  CRLEEV----FRIPSLQQLHLQRNALCVIPQDF-FQLLPNLTWLDLRYNRIKALPSGIGA 112
           C LE +    F + +L +L L+ N L  + +   FQ L NL+ L L +N I  +P+ IGA
Sbjct: 595 CDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGA 654

Query: 113 HQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQ 154
             +L+ L L+ N I+ LP++L   T L  L+L +  L F P+
Sbjct: 655 LSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPE 696



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 2/95 (2%)

Query: 62  EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLL 121
           ++F    L  L L  N L  IP++  Q L NL +  +  N I+ LP G+   + L+ LLL
Sbjct: 674 QLFLCTKLHYLDLSYNHLTFIPEEI-QYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLL 732

Query: 122 ERNPIKMLPVELGSVTTLKALNLRHCPLE-FPPQL 155
            +N +  L   +G ++ L  L L    LE  PP+L
Sbjct: 733 GKNSLMNLSPHVGELSNLTHLELIGNYLETLPPEL 767



 Score = 30.8 bits (68), Expect = 3.2
 Identities = 24/71 (33%), Positives = 38/71 (53%), Gaps = 3/71 (4%)

Query: 63  VFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLK--TLL 120
           +F+   LQ L L +N+L  +     +L  NLT L+L  N ++ LP  +   Q LK   L+
Sbjct: 721 LFQCKKLQCLLLGKNSLMNLSPHVGEL-SNLTHLELIGNYLETLPPELEGCQSLKRNCLI 779

Query: 121 LERNPIKMLPV 131
           +E N +  LP+
Sbjct: 780 VEENLLNTLPL 790


>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
           sapiens]
          Length = 803

 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 5/102 (4%)

Query: 58  CRLEEV----FRIPSLQQLHLQRNALCVIPQDF-FQLLPNLTWLDLRYNRIKALPSGIGA 112
           C LE +    F + +L +L L+ N L  + +   FQ L NL+ L L +N I  +P+ IGA
Sbjct: 595 CDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGA 654

Query: 113 HQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQ 154
             +L+ L L+ N I+ LP++L   T L  L+L +  L F P+
Sbjct: 655 LSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPE 696



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 2/95 (2%)

Query: 62  EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLL 121
           ++F    L  L L  N L  IP++  Q L NL +  +  N I+ LP G+   + L+ LLL
Sbjct: 674 QLFLCTKLHYLDLSYNHLTFIPEEI-QYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLL 732

Query: 122 ERNPIKMLPVELGSVTTLKALNLRHCPLE-FPPQL 155
            +N +  L   +G ++ L  L L    LE  PP+L
Sbjct: 733 GKNSLMNLSPHVGELSNLTHLELIGNYLETLPPEL 767



 Score = 30.8 bits (68), Expect = 3.2
 Identities = 24/71 (33%), Positives = 38/71 (53%), Gaps = 3/71 (4%)

Query: 63  VFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLK--TLL 120
           +F+   LQ L L +N+L  +     +L  NLT L+L  N ++ LP  +   Q LK   L+
Sbjct: 721 LFQCKKLQCLLLGKNSLMNLSPHVGEL-SNLTHLELIGNYLETLPPELEGCQSLKRNCLI 779

Query: 121 LERNPIKMLPV 131
           +E N +  LP+
Sbjct: 780 VEENLLNTLPL 790


>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
           sapiens]
          Length = 810

 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 40/119 (33%), Positives = 61/119 (51%), Gaps = 7/119 (5%)

Query: 42  IIFSSSPILDLSESGLCRLE------EVFRIPSLQQLHLQRNALCVIPQDF-FQLLPNLT 94
           ++ S   + +L+E  L R +       +F + +LQ++ L+ N L  I +   FQ L  LT
Sbjct: 583 VLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLT 642

Query: 95  WLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPP 153
            L L YN I  +P  IG   +L+ L L RN I+ +P +L     L+ L+L H  L F P
Sbjct: 643 CLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLP 701



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 33/95 (34%), Positives = 53/95 (55%), Gaps = 1/95 (1%)

Query: 62  EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLL 121
           ++  + +L++L+L RN +  IP   F     L +LDL +N +  LP+ IG  Q+L+ L +
Sbjct: 657 QIGNLTNLERLYLNRNKIEKIPTQLFYCR-KLRYLDLSHNNLTFLPADIGLLQNLQNLAI 715

Query: 122 ERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLV 156
             N I+ LP EL     L+AL+L +  L+  P  V
Sbjct: 716 TANRIETLPPELFQCRKLRALHLGNNVLQSLPSRV 750



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 32/92 (34%), Positives = 46/92 (50%), Gaps = 1/92 (1%)

Query: 62  EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLL 121
           ++F    L+ L L  N L  +P D   LL NL  L +  NRI+ LP  +   + L+ L L
Sbjct: 680 QLFYCRKLRYLDLSHNNLTFLPADI-GLLQNLQNLAITANRIETLPPELFQCRKLRALHL 738

Query: 122 ERNPIKMLPVELGSVTTLKALNLRHCPLEFPP 153
             N ++ LP  +G +T L  + LR   LE  P
Sbjct: 739 GNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 33/96 (34%), Positives = 50/96 (52%), Gaps = 2/96 (2%)

Query: 50  LDLSESGLCRLE-EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
           LDLS + L  L  ++  + +LQ L +  N +  +P + FQ    L  L L  N +++LPS
Sbjct: 690 LDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCR-KLRALHLGNNVLQSLPS 748

Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNL 144
            +G   +L  + L  N ++ LPVELG    LK   L
Sbjct: 749 RVGELTNLTQIELRGNRLECLPVELGECPLLKRSGL 784



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 34/119 (28%), Positives = 58/119 (48%), Gaps = 5/119 (4%)

Query: 50  LDLSESGLCRLEEVFRIPSLQQL---HLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKAL 106
           +DL ++ L  +EE+     L +L    L  N +  IP     L  NL  L L  N+I+ +
Sbjct: 619 IDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLT-NLERLYLNRNKIEKI 677

Query: 107 PSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLE-FPPQLVVQKGLVAI 164
           P+ +   + L+ L L  N +  LP ++G +  L+ L +    +E  PP+L   + L A+
Sbjct: 678 PTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRAL 736


>gi|187829877 leucine rich repeat containing 8 family, member A
           [Homo sapiens]
          Length = 810

 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 40/119 (33%), Positives = 61/119 (51%), Gaps = 7/119 (5%)

Query: 42  IIFSSSPILDLSESGLCRLE------EVFRIPSLQQLHLQRNALCVIPQDF-FQLLPNLT 94
           ++ S   + +L+E  L R +       +F + +LQ++ L+ N L  I +   FQ L  LT
Sbjct: 583 VLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLT 642

Query: 95  WLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPP 153
            L L YN I  +P  IG   +L+ L L RN I+ +P +L     L+ L+L H  L F P
Sbjct: 643 CLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLP 701



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 33/95 (34%), Positives = 53/95 (55%), Gaps = 1/95 (1%)

Query: 62  EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLL 121
           ++  + +L++L+L RN +  IP   F     L +LDL +N +  LP+ IG  Q+L+ L +
Sbjct: 657 QIGNLTNLERLYLNRNKIEKIPTQLFYCR-KLRYLDLSHNNLTFLPADIGLLQNLQNLAI 715

Query: 122 ERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLV 156
             N I+ LP EL     L+AL+L +  L+  P  V
Sbjct: 716 TANRIETLPPELFQCRKLRALHLGNNVLQSLPSRV 750



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 32/92 (34%), Positives = 46/92 (50%), Gaps = 1/92 (1%)

Query: 62  EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLL 121
           ++F    L+ L L  N L  +P D   LL NL  L +  NRI+ LP  +   + L+ L L
Sbjct: 680 QLFYCRKLRYLDLSHNNLTFLPADI-GLLQNLQNLAITANRIETLPPELFQCRKLRALHL 738

Query: 122 ERNPIKMLPVELGSVTTLKALNLRHCPLEFPP 153
             N ++ LP  +G +T L  + LR   LE  P
Sbjct: 739 GNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 33/96 (34%), Positives = 50/96 (52%), Gaps = 2/96 (2%)

Query: 50  LDLSESGLCRLE-EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
           LDLS + L  L  ++  + +LQ L +  N +  +P + FQ    L  L L  N +++LPS
Sbjct: 690 LDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCR-KLRALHLGNNVLQSLPS 748

Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNL 144
            +G   +L  + L  N ++ LPVELG    LK   L
Sbjct: 749 RVGELTNLTQIELRGNRLECLPVELGECPLLKRSGL 784



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 34/119 (28%), Positives = 58/119 (48%), Gaps = 5/119 (4%)

Query: 50  LDLSESGLCRLEEVFRIPSLQQL---HLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKAL 106
           +DL ++ L  +EE+     L +L    L  N +  IP     L  NL  L L  N+I+ +
Sbjct: 619 IDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLT-NLERLYLNRNKIEKI 677

Query: 107 PSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLE-FPPQLVVQKGLVAI 164
           P+ +   + L+ L L  N +  LP ++G +  L+ L +    +E  PP+L   + L A+
Sbjct: 678 PTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRAL 736


>gi|187829871 leucine rich repeat containing 8 family, member A
           [Homo sapiens]
          Length = 810

 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 40/119 (33%), Positives = 61/119 (51%), Gaps = 7/119 (5%)

Query: 42  IIFSSSPILDLSESGLCRLE------EVFRIPSLQQLHLQRNALCVIPQDF-FQLLPNLT 94
           ++ S   + +L+E  L R +       +F + +LQ++ L+ N L  I +   FQ L  LT
Sbjct: 583 VLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLT 642

Query: 95  WLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPP 153
            L L YN I  +P  IG   +L+ L L RN I+ +P +L     L+ L+L H  L F P
Sbjct: 643 CLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLP 701



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 33/95 (34%), Positives = 53/95 (55%), Gaps = 1/95 (1%)

Query: 62  EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLL 121
           ++  + +L++L+L RN +  IP   F     L +LDL +N +  LP+ IG  Q+L+ L +
Sbjct: 657 QIGNLTNLERLYLNRNKIEKIPTQLFYCR-KLRYLDLSHNNLTFLPADIGLLQNLQNLAI 715

Query: 122 ERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLV 156
             N I+ LP EL     L+AL+L +  L+  P  V
Sbjct: 716 TANRIETLPPELFQCRKLRALHLGNNVLQSLPSRV 750



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 32/92 (34%), Positives = 46/92 (50%), Gaps = 1/92 (1%)

Query: 62  EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLL 121
           ++F    L+ L L  N L  +P D   LL NL  L +  NRI+ LP  +   + L+ L L
Sbjct: 680 QLFYCRKLRYLDLSHNNLTFLPADI-GLLQNLQNLAITANRIETLPPELFQCRKLRALHL 738

Query: 122 ERNPIKMLPVELGSVTTLKALNLRHCPLEFPP 153
             N ++ LP  +G +T L  + LR   LE  P
Sbjct: 739 GNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 33/96 (34%), Positives = 50/96 (52%), Gaps = 2/96 (2%)

Query: 50  LDLSESGLCRLE-EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
           LDLS + L  L  ++  + +LQ L +  N +  +P + FQ    L  L L  N +++LPS
Sbjct: 690 LDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCR-KLRALHLGNNVLQSLPS 748

Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNL 144
            +G   +L  + L  N ++ LPVELG    LK   L
Sbjct: 749 RVGELTNLTQIELRGNRLECLPVELGECPLLKRSGL 784



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 34/119 (28%), Positives = 58/119 (48%), Gaps = 5/119 (4%)

Query: 50  LDLSESGLCRLEEVFRIPSLQQL---HLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKAL 106
           +DL ++ L  +EE+     L +L    L  N +  IP     L  NL  L L  N+I+ +
Sbjct: 619 IDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLT-NLERLYLNRNKIEKI 677

Query: 107 PSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLE-FPPQLVVQKGLVAI 164
           P+ +   + L+ L L  N +  LP ++G +  L+ L +    +E  PP+L   + L A+
Sbjct: 678 PTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRAL 736


>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
          Length = 524

 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 35/94 (37%), Positives = 48/94 (51%), Gaps = 1/94 (1%)

Query: 61  EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
           E +  + +L  L L+ N L  +P    QL   L  LDL  N I  LP  IGA  HLK L 
Sbjct: 145 ENIGNLYNLASLELRENLLTYLPDSLTQLR-RLEELDLGNNEIYNLPESIGALLHLKDLW 203

Query: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQ 154
           L+ N +  LP E+G++  L  L++    LE  P+
Sbjct: 204 LDGNQLSELPQEIGNLKNLLCLDVSENRLERLPE 237



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 35/95 (36%), Positives = 50/95 (52%), Gaps = 2/95 (2%)

Query: 50  LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
           LD+SE+ L RL EE+  + SL  L + +N L  IP D    L  L+ L +  NR+  LP 
Sbjct: 225 LDVSENRLERLPEEISGLTSLTDLVISQNLLETIP-DGIGKLKKLSILKVDQNRLTQLPE 283

Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALN 143
            +G  + L  L+L  N +  LP  +G +  L  LN
Sbjct: 284 AVGECESLTELVLTENQLLTLPKSIGKLKKLSNLN 318



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 32/108 (29%), Positives = 52/108 (48%), Gaps = 2/108 (1%)

Query: 50  LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
           LDL  + +  L E +  +  L+ L L  N L  +PQ+   L  NL  LD+  NR++ LP 
Sbjct: 179 LDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNL-KNLLCLDVSENRLERLPE 237

Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLV 156
            I     L  L++ +N ++ +P  +G +  L  L +    L   P+ V
Sbjct: 238 EISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAV 285



 Score = 37.7 bits (86), Expect = 0.026
 Identities = 32/107 (29%), Positives = 50/107 (46%), Gaps = 7/107 (6%)

Query: 49  ILDLSESGLCRLEE-VFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALP 107
           IL + ++ L +L E V    SL +L L  N L  +P+   +L   L+ L+   N++ +LP
Sbjct: 270 ILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKL-KKLSNLNADRNKLVSLP 328

Query: 108 SGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALN-----LRHCPL 149
             IG    L    +  N +  +P E+   T L  L+     L H PL
Sbjct: 329 KEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPL 375



 Score = 37.0 bits (84), Expect = 0.045
 Identities = 30/117 (25%), Positives = 47/117 (40%), Gaps = 23/117 (19%)

Query: 61  EEVFRIP-SLQQLHLQRNALCVIPQDFFQLLP----------------------NLTWLD 97
           EE++R   SL++L L  N L  +P+ FFQL+                        L  LD
Sbjct: 29  EEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELD 88

Query: 98  LRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQ 154
           +  N I  +P  I   + L+      NP+  LP     +  L  L++    L+  P+
Sbjct: 89  VSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPE 145



 Score = 37.0 bits (84), Expect = 0.045
 Identities = 29/96 (30%), Positives = 48/96 (50%), Gaps = 2/96 (2%)

Query: 50  LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
           LD+S + +  + E +    +LQ      N L  +P+ F +L  NLT L +    +++LP 
Sbjct: 87  LDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPEL-QNLTCLSVNDISLQSLPE 145

Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNL 144
            IG   +L +L L  N +  LP  L  +  L+ L+L
Sbjct: 146 NIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDL 181



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 46/169 (27%), Positives = 72/169 (42%), Gaps = 11/169 (6%)

Query: 50  LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
           L L+E+ L  L + + ++  L  L+  RN L  +P++      +LT   +R NR+  +P+
Sbjct: 294 LVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCC-SLTVFCVRDNRLTRIPA 352

Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGL-VAIQRF 167
            +     L  L +  N +  LP+   S+T LK   L     +  P L  Q          
Sbjct: 353 EVSQATELHVLDVAGNRLLHLPL---SLTALKLKALWLSDNQSQPLLTFQTDTDYTTGEK 409

Query: 168 LRMWAVEHSLPRNPTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVN 216
           +    +   LP  PT QE  P R   L +L +       D A N+ AVN
Sbjct: 410 ILTCVLLPQLPSEPTCQENLP-RCGALENLVND----VSDEAWNERAVN 453



 Score = 29.6 bits (65), Expect = 7.1
 Identities = 22/85 (25%), Positives = 40/85 (47%), Gaps = 1/85 (1%)

Query: 78  ALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVT 137
           +L  +P++ ++   +L  L L  N+++ LP        L+ L L  N I+ LP E+ +  
Sbjct: 23  SLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFM 82

Query: 138 TLKALNLRHCPL-EFPPQLVVQKGL 161
            L  L++    + E P  +   K L
Sbjct: 83  QLVELDVSRNEIPEIPESISFCKAL 107


>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
          Length = 1302

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 34/117 (29%), Positives = 60/117 (51%), Gaps = 4/117 (3%)

Query: 50  LDLSESGLCRLEEVF-RIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
           LDL  +    + EV  ++  L++  +  N L  IP  F   L  LT+LD+  N I+ +  
Sbjct: 189 LDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIP-GFIGSLKQLTYLDVSKNNIEMVEE 247

Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQ 165
           GI   ++L+ LLL  N ++ LP  +GS+  +  L +    L + P  +   GL++++
Sbjct: 248 GISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSI--GGLISVE 302



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 32/104 (30%), Positives = 53/104 (50%), Gaps = 2/104 (1%)

Query: 52  LSESGLCRLEEVF-RIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGI 110
           LS + L +L E    + ++  L +  N L  +P     L+ ++  LD  +N ++ALPS I
Sbjct: 260 LSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLI-SVEELDCSFNEVEALPSSI 318

Query: 111 GAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQ 154
           G   +L+T   + N ++ LP E+GS   +  L L    LE  P+
Sbjct: 319 GQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPE 362



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 37/138 (26%), Positives = 65/138 (47%), Gaps = 8/138 (5%)

Query: 50  LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
           L + E+ L  L + +  + S+++L    N +  +P    QL  NL      +N ++ LP 
Sbjct: 281 LKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLT-NLRTFAADHNYLQQLPP 339

Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFL 168
            IG+ +++  L L  N ++ LP E+G +  LK +NL    L+  P          +Q+  
Sbjct: 340 EIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP-----FSFTKLQQLT 394

Query: 169 RMWAVEH-SLPRNPTSQE 185
            MW  ++ S P  P  +E
Sbjct: 395 AMWLSDNQSKPLIPLQKE 412



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 34/110 (30%), Positives = 54/110 (49%), Gaps = 2/110 (1%)

Query: 50  LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
           LD+S++G+    E +     L  +    N +  +P  F QLL NLT L L    ++ LP+
Sbjct: 97  LDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLL-NLTQLYLNDAFLEFLPA 155

Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQ 158
             G    L+ L L  N +KMLP  +  +T L+ L+L        P+++ Q
Sbjct: 156 NFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQ 205



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 30/93 (32%), Positives = 41/93 (44%), Gaps = 1/93 (1%)

Query: 61  EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
           +++F   SL +L L  N L  +P     L+ NL  LD+  N I+  P  I   + L  + 
Sbjct: 63  KQLFNCQSLHKLSLPDNDLTTLPASIANLI-NLRELDVSKNGIQEFPENIKNCKVLTIVE 121

Query: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPP 153
              NPI  LP     +  L  L L    LEF P
Sbjct: 122 ASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLP 154



 Score = 35.0 bits (79), Expect = 0.17
 Identities = 29/117 (24%), Positives = 54/117 (46%), Gaps = 6/117 (5%)

Query: 65  RIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERN 124
           R+  LQ L L+ N L ++P+   +L   L  LDL  N    +P  +     LK   ++ N
Sbjct: 159 RLTKLQILELRENQLKMLPKTMNRLT-QLERLDLGSNEFTEVPEVLEQLSGLKEFWMDAN 217

Query: 125 PIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRNP 181
            +  +P  +GS+  L  L++    +E     +V++G+   +    +    +SL + P
Sbjct: 218 RLTFIPGFIGSLKQLTYLDVSKNNIE-----MVEEGISTCENLQDLLLSSNSLQQLP 269



 Score = 34.3 bits (77), Expect = 0.29
 Identities = 31/109 (28%), Positives = 54/109 (49%), Gaps = 2/109 (1%)

Query: 49  ILDLSESGLCRLEEVF-RIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALP 107
           I++ S + + +L + F ++ +L QL+L    L  +P +F +L   L  L+LR N++K LP
Sbjct: 119 IVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLT-KLQILELRENQLKMLP 177

Query: 108 SGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLV 156
             +     L+ L L  N    +P  L  ++ LK   +    L F P  +
Sbjct: 178 KTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFI 226



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 23/85 (27%), Positives = 41/85 (48%), Gaps = 1/85 (1%)

Query: 82  IPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKA 141
           +P++ F     L  L L  N+I+ LP  +   Q L  L L  N +  LP  + ++  L+ 
Sbjct: 37  VPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRE 96

Query: 142 LNL-RHCPLEFPPQLVVQKGLVAIQ 165
           L++ ++   EFP  +   K L  ++
Sbjct: 97  LDVSKNGIQEFPENIKNCKVLTIVE 121


>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
          Length = 1371

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 34/117 (29%), Positives = 60/117 (51%), Gaps = 4/117 (3%)

Query: 50  LDLSESGLCRLEEVF-RIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
           LDL  +    + EV  ++  L++  +  N L  IP  F   L  LT+LD+  N I+ +  
Sbjct: 189 LDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIP-GFIGSLKQLTYLDVSKNNIEMVEE 247

Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQ 165
           GI   ++L+ LLL  N ++ LP  +GS+  +  L +    L + P  +   GL++++
Sbjct: 248 GISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSI--GGLISVE 302



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 32/104 (30%), Positives = 53/104 (50%), Gaps = 2/104 (1%)

Query: 52  LSESGLCRLEEVF-RIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGI 110
           LS + L +L E    + ++  L +  N L  +P     L+ ++  LD  +N ++ALPS I
Sbjct: 260 LSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLI-SVEELDCSFNEVEALPSSI 318

Query: 111 GAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQ 154
           G   +L+T   + N ++ LP E+GS   +  L L    LE  P+
Sbjct: 319 GQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPE 362



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 37/138 (26%), Positives = 65/138 (47%), Gaps = 8/138 (5%)

Query: 50  LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
           L + E+ L  L + +  + S+++L    N +  +P    QL  NL      +N ++ LP 
Sbjct: 281 LKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLT-NLRTFAADHNYLQQLPP 339

Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFL 168
            IG+ +++  L L  N ++ LP E+G +  LK +NL    L+  P          +Q+  
Sbjct: 340 EIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP-----FSFTKLQQLT 394

Query: 169 RMWAVEH-SLPRNPTSQE 185
            MW  ++ S P  P  +E
Sbjct: 395 AMWLSDNQSKPLIPLQKE 412



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 34/110 (30%), Positives = 54/110 (49%), Gaps = 2/110 (1%)

Query: 50  LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
           LD+S++G+    E +     L  +    N +  +P  F QLL NLT L L    ++ LP+
Sbjct: 97  LDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLL-NLTQLYLNDAFLEFLPA 155

Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQ 158
             G    L+ L L  N +KMLP  +  +T L+ L+L        P+++ Q
Sbjct: 156 NFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQ 205



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 30/93 (32%), Positives = 41/93 (44%), Gaps = 1/93 (1%)

Query: 61  EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
           +++F   SL +L L  N L  +P     L+ NL  LD+  N I+  P  I   + L  + 
Sbjct: 63  KQLFNCQSLHKLSLPDNDLTTLPASIANLI-NLRELDVSKNGIQEFPENIKNCKVLTIVE 121

Query: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPP 153
              NPI  LP     +  L  L L    LEF P
Sbjct: 122 ASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLP 154



 Score = 35.0 bits (79), Expect = 0.17
 Identities = 29/117 (24%), Positives = 54/117 (46%), Gaps = 6/117 (5%)

Query: 65  RIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERN 124
           R+  LQ L L+ N L ++P+   +L   L  LDL  N    +P  +     LK   ++ N
Sbjct: 159 RLTKLQILELRENQLKMLPKTMNRLT-QLERLDLGSNEFTEVPEVLEQLSGLKEFWMDAN 217

Query: 125 PIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRNP 181
            +  +P  +GS+  L  L++    +E     +V++G+   +    +    +SL + P
Sbjct: 218 RLTFIPGFIGSLKQLTYLDVSKNNIE-----MVEEGISTCENLQDLLLSSNSLQQLP 269



 Score = 34.3 bits (77), Expect = 0.29
 Identities = 31/109 (28%), Positives = 54/109 (49%), Gaps = 2/109 (1%)

Query: 49  ILDLSESGLCRLEEVF-RIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALP 107
           I++ S + + +L + F ++ +L QL+L    L  +P +F +L   L  L+LR N++K LP
Sbjct: 119 IVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLT-KLQILELRENQLKMLP 177

Query: 108 SGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLV 156
             +     L+ L L  N    +P  L  ++ LK   +    L F P  +
Sbjct: 178 KTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFI 226



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 23/85 (27%), Positives = 41/85 (48%), Gaps = 1/85 (1%)

Query: 82  IPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKA 141
           +P++ F     L  L L  N+I+ LP  +   Q L  L L  N +  LP  + ++  L+ 
Sbjct: 37  VPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRE 96

Query: 142 LNL-RHCPLEFPPQLVVQKGLVAIQ 165
           L++ ++   EFP  +   K L  ++
Sbjct: 97  LDVSKNGIQEFPENIKNCKVLTIVE 121


>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
          Length = 347

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 35/97 (36%), Positives = 56/97 (57%), Gaps = 2/97 (2%)

Query: 49  ILDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALP 107
           +L+L+ + L +L +EV R+ SL  + +  N L  IP++    L NL  L L YN++  +P
Sbjct: 111 LLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELC-FLENLVELQLNYNQLICIP 169

Query: 108 SGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNL 144
             I   + L+ LLL RN I +LP EL  +  L+ L++
Sbjct: 170 EEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDI 206



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 31/108 (28%), Positives = 49/108 (45%), Gaps = 2/108 (1%)

Query: 61  EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
           EE+  + SL+ LHL  N +C         L NL  L+L  N +  LP  +   + L  + 
Sbjct: 77  EEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMS 136

Query: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFL 168
           +  N +  +P EL  +  L  L L +  L   P+ +  K L  +Q+ L
Sbjct: 137 INYNQLASIPRELCFLENLVELQLNYNQLICIPEEI--KFLKKLQKLL 182



 Score = 35.0 bits (79), Expect = 0.17
 Identities = 22/63 (34%), Positives = 34/63 (53%)

Query: 92  NLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEF 151
           N   + L   ++  +PS +G    LKTL+L+ N I  +  EL ++T L  LNL +  LE 
Sbjct: 15  NTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEE 74

Query: 152 PPQ 154
            P+
Sbjct: 75  VPE 77


>gi|61742782 leucine rich repeat and death domain containing protein
           isoform 2 [Homo sapiens]
          Length = 753

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 50/166 (30%), Positives = 75/166 (45%), Gaps = 9/166 (5%)

Query: 69  LQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKM 128
           L  L L  N L  +P+     LP LT+L + +NR++ LP  +GA   L+ L L +N +  
Sbjct: 4   LGALLLSHNCLSELPEAL-GALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDT 62

Query: 129 LPVELGSVTTLKALNLRHCPLE-FPPQLVVQKGLVAIQRFLRMWA-VEHSLPRNPTSQEA 186
           LP E+G + +L  LNL    L+  P  L   + L  +     + A V   L R P     
Sbjct: 63  LPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRL 122

Query: 187 PPVREMTLRDLP-----SPGLELSGDHASNQGAVNAQDPEGAVMKE 227
             +R+  LRDLP     +P + L G+            P  A++ E
Sbjct: 123 -DLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPE 167


>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
          Length = 277

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 38/118 (32%), Positives = 62/118 (52%), Gaps = 4/118 (3%)

Query: 32  SKDVHKGVGGIIFSSSPILDLSESGLCRLEEV---FRIPSLQQLHLQRNALCVIPQDFFQ 88
           SK + K V      + P +D+S+ G+  + +V   F +  + QL L  N L ++P +  +
Sbjct: 2   SKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAE 61

Query: 89  LLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRH 146
           L  NL  L+   N+I+ LP+ I + Q LK L L  N +  LP   GS+  L+ L+L +
Sbjct: 62  L-KNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTY 118



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 40/154 (25%), Positives = 68/154 (44%), Gaps = 10/154 (6%)

Query: 44  FSSSPILDLSESGLCRLEE------VFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLD 97
           F S P L++ +     L E       F + +L+ L+L  N   ++P D  +L   L  L 
Sbjct: 105 FGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLT-KLQILS 163

Query: 98  LRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTL---KALNLRHCPLEFPPQ 154
           LR N + +LP  IG    LK L ++ N + +LP ELG++      +     + P   P  
Sbjct: 164 LRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIA 223

Query: 155 LVVQKGLVAIQRFLRMWAVEHSLPRNPTSQEAPP 188
              Q G+  +  ++R    ++   R+  +   PP
Sbjct: 224 DQFQLGVSHVFEYIRSETYKYLYGRHMQANPEPP 257


>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
          Length = 602

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 36/102 (35%), Positives = 52/102 (50%), Gaps = 2/102 (1%)

Query: 61  EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLL 120
           EE+  + +L+ L+LQ N L  I + F QL  NL  LDL  N +  +P+   +   L  L 
Sbjct: 145 EEITNLRNLKCLYLQHNELTCISEGFEQL-SNLEDLDLSNNHLTTVPASFSSLSSLVRLN 203

Query: 121 LERNPIKMLPVELGSVTTLKALNLRHCPLE-FPPQLVVQKGL 161
           L  N +K LP E+  +  LK L+     LE  PP+L   + L
Sbjct: 204 LSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESL 245



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 43/149 (28%), Positives = 72/149 (48%), Gaps = 5/149 (3%)

Query: 46  SSPILDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKA 105
           S  +L L  + L  L E      L++LH+  N + ++  +  + L ++  LDLR N++K+
Sbjct: 244 SLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKS 303

Query: 106 LPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQ 165
           +P  I   + L+ L L  N I  LP  LG++  LK L L   PL    + ++ KG   + 
Sbjct: 304 VPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVL 362

Query: 166 RFLRMWAVEHSLPRNPTSQEAPPVREMTL 194
           ++LR    +      P+  E+     MTL
Sbjct: 363 KYLRSKIKDD----GPSQSESATETAMTL 387



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 29/78 (37%), Positives = 47/78 (60%), Gaps = 1/78 (1%)

Query: 69  LQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKM 128
           L +L +  N L  +  D  +LLP LT LD+  N++ +LPS I   ++L+ L +  N +K+
Sbjct: 84  LTKLIISNNKLQSLTDDL-RLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKI 142

Query: 129 LPVELGSVTTLKALNLRH 146
           LP E+ ++  LK L L+H
Sbjct: 143 LPEEITNLRNLKCLYLQH 160



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 40/145 (27%), Positives = 66/145 (45%), Gaps = 26/145 (17%)

Query: 50  LDLSESGLCRLE-EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALP- 107
           +DLS + L  +  E+  +  L  L L+ N L  +P++   L+  L  ++L +NR K LP 
Sbjct: 454 VDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLV-RLQTINLSFNRFKMLPE 512

Query: 108 ---------------SGIGA--------HQHLKTLLLERNPIKMLPVELGSVTTLKALNL 144
                          + +G+         ++L TL L+ N +  +P ELG+   L+ L L
Sbjct: 513 VLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLL 572

Query: 145 RHCPLEFPPQLVVQKGLVAIQRFLR 169
              P   P   ++ KG  AI  +LR
Sbjct: 573 DGNPFRVPRAAILMKGTAAILEYLR 597



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 29/112 (25%), Positives = 56/112 (50%), Gaps = 4/112 (3%)

Query: 49  ILDLSESGLCRL-EEVF---RIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIK 104
           ILD S+     + +EVF   +   +  ++  +N LC IP+   +L   ++ +DL +N++ 
Sbjct: 403 ILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLS 462

Query: 105 ALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLV 156
            +   +   Q L  L L  N +  LP E+ S+  L+ +NL     +  P+++
Sbjct: 463 FISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVL 514



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 31/102 (30%), Positives = 52/102 (50%), Gaps = 3/102 (2%)

Query: 50  LDLSESGLCRLEEVFR-IPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
           LDLS + L  +   F  + SL +L+L  N L  +P +  ++   L  LD   N ++ +P 
Sbjct: 179 LDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRM-KRLKHLDCNSNLLETIPP 237

Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLE 150
            +   + L+ L L RN ++ LP E  S + LK L++    +E
Sbjct: 238 ELAGMESLELLYLRRNKLRFLP-EFPSCSLLKELHVGENQIE 278



 Score = 38.5 bits (88), Expect = 0.015
 Identities = 30/97 (30%), Positives = 52/97 (53%), Gaps = 7/97 (7%)

Query: 50  LDLSESGLCRLEEVFRIPSLQQL----HLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKA 105
           ++ S++ LC + +  R+  L+++     L  N L  I  +   +L  LT+LDLR N + +
Sbjct: 430 INFSKNQLCEIPK--RMVELKEMVSDVDLSFNKLSFISLELC-VLQKLTFLDLRNNFLNS 486

Query: 106 LPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKAL 142
           LP  + +   L+T+ L  N  KMLP  L  + TL+ +
Sbjct: 487 LPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETI 523


>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
          Length = 335

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 31/82 (37%), Positives = 43/82 (52%), Gaps = 1/82 (1%)

Query: 63  VFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLE 122
           + ++  LQ+  L R  L  IP+ F     NL  LDL  N I  +P GIG    L+ L+L 
Sbjct: 79  LLKLNQLQEWQLHRTGLLKIPE-FIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILS 137

Query: 123 RNPIKMLPVELGSVTTLKALNL 144
            N IK +P EL +  +L+ L L
Sbjct: 138 YNKIKTVPKELSNCASLEKLEL 159



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 33/98 (33%), Positives = 49/98 (50%), Gaps = 2/98 (2%)

Query: 57  LCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQH 115
           +C L +E+  +  L  L L  N    IP     + P L WLD+  N+++ LP  I   Q+
Sbjct: 165 ICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNM-PALEWLDMGSNKLEQLPDTIERMQN 223

Query: 116 LKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPP 153
           L TL L+RN I  LP  + ++  L  L L +  L+  P
Sbjct: 224 LHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIP 261



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 35/112 (31%), Positives = 57/112 (50%), Gaps = 2/112 (1%)

Query: 50  LDLSESGLCRLE-EVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPS 108
           LDLS +    +   V  +P+L+ L +  N L  +P D  + + NL  L L+ N I  LP 
Sbjct: 181 LDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLP-DTIERMQNLHTLWLQRNEITCLPQ 239

Query: 109 GIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKG 160
            I   ++L TL+L  N ++ +PV +  +  L+ +N R  PL+    L   +G
Sbjct: 240 TISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEG 291



 Score = 37.4 bits (85), Expect = 0.034
 Identities = 34/95 (35%), Positives = 47/95 (49%), Gaps = 3/95 (3%)

Query: 52  LSESGLCRLEE-VFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGI 110
           L  +GL ++ E + R  +L  L L RN +  IP     LL  L  L L YN+IK +P  +
Sbjct: 90  LHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGI-GLLTRLQELILSYNKIKTVPKEL 148

Query: 111 GAHQHLKTLLLERN-PIKMLPVELGSVTTLKALNL 144
                L+ L L  N  I  LP EL ++  L  L+L
Sbjct: 149 SNCASLEKLELAVNRDICDLPQELSNLLKLTHLDL 183


>gi|40254924 leucine rich repeat containing 59 [Homo sapiens]
          Length = 307

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 34/101 (33%), Positives = 52/101 (51%), Gaps = 1/101 (0%)

Query: 50  LDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSG 109
           L LS+     ++E+  +P    L L  N L  +P DF  L  +L  LDL  N+++ LP+ 
Sbjct: 22  LSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLT-HLVKLDLSKNKLQQLPAD 80

Query: 110 IGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLE 150
            G   +L+ L L  N +  LPV    +  LK L+L+  PL+
Sbjct: 81  FGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLD 121



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 25/74 (33%), Positives = 37/74 (50%)

Query: 71  QLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLP 130
           +L L  + L  +P      LP  T LDL  N++  LPS      HL  L L +N ++ LP
Sbjct: 19  ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78

Query: 131 VELGSVTTLKALNL 144
            + G +  L+ L+L
Sbjct: 79  ADFGRLVNLQHLDL 92


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.131    0.371 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,481,640
Number of Sequences: 37866
Number of extensions: 1051679
Number of successful extensions: 9926
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 276
Number of HSP's successfully gapped in prelim test: 622
Number of HSP's that attempted gapping in prelim test: 6009
Number of HSP's gapped (non-prelim): 2926
length of query: 530
length of database: 18,247,518
effective HSP length: 107
effective length of query: 423
effective length of database: 14,195,856
effective search space: 6004847088
effective search space used: 6004847088
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.