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Search of human proteins with 219521878
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
(459 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 942 0.0
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 833 0.0
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 833 0.0
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 833 0.0
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 569 e-162
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 569 e-162
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 546 e-155
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 545 e-155
gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [H... 487 e-138
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 350 2e-96
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 348 6e-96
gi|4502023 AKT2 kinase [Homo sapiens] 329 3e-90
gi|62241015 AKT1 kinase [Homo sapiens] 326 3e-89
gi|62241013 AKT1 kinase [Homo sapiens] 326 3e-89
gi|62241011 AKT1 kinase [Homo sapiens] 326 3e-89
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 308 7e-84
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 306 2e-83
gi|4506067 protein kinase C, alpha [Homo sapiens] 299 3e-81
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 299 4e-81
gi|4885563 protein kinase C, epsilon [Homo sapiens] 296 3e-80
gi|133908623 protein kinase C, iota [Homo sapiens] 294 1e-79
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 289 4e-78
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 289 4e-78
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 289 4e-78
gi|13384594 protein kinase C, gamma [Homo sapiens] 288 5e-78
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 287 1e-77
gi|28557781 protein kinase C, eta [Homo sapiens] 286 4e-77
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 284 1e-76
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 283 2e-76
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 283 2e-76
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 942 bits (2434), Expect = 0.0
Identities = 459/459 (100%), Positives = 459/459 (100%)
Query: 1 MSSQSSSLSEACSREAYSSHNWALPPASRSNPQPAYPWATRRMKEEAIKPPLKAFMKQRR 60
MSSQSSSLSEACSREAYSSHNWALPPASRSNPQPAYPWATRRMKEEAIKPPLKAFMKQRR
Sbjct: 1 MSSQSSSLSEACSREAYSSHNWALPPASRSNPQPAYPWATRRMKEEAIKPPLKAFMKQRR 60
Query: 61 MGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPH 120
MGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPH
Sbjct: 61 MGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPH 120
Query: 121 AKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLK 180
AKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLK
Sbjct: 121 AKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLK 180
Query: 181 NVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGY 240
NVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGY
Sbjct: 181 NVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGY 240
Query: 241 LHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQ 300
LHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQ
Sbjct: 241 LHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQ 300
Query: 301 PYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLL 360
PYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLL
Sbjct: 301 PYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLL 360
Query: 361 QKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 420
QKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE
Sbjct: 361 QKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 420
Query: 421 PVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 459
PVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
Sbjct: 421 PVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 459
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 833 bits (2153), Expect = 0.0
Identities = 407/408 (99%), Positives = 407/408 (99%)
Query: 52 LKAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQI 111
L AFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQI
Sbjct: 24 LIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQI 83
Query: 112 NLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHI 171
NLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHI
Sbjct: 84 NLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHI 143
Query: 172 MSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYA 231
MSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYA
Sbjct: 144 MSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYA 203
Query: 232 AEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEY 291
AEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEY
Sbjct: 204 AEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEY 263
Query: 292 LAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNS 351
LAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNS
Sbjct: 264 LAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNS 323
Query: 352 ARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLR 411
ARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLR
Sbjct: 324 ARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLR 383
Query: 412 HFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 459
HFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
Sbjct: 384 HFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 431
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 833 bits (2152), Expect = 0.0
Identities = 406/406 (100%), Positives = 406/406 (100%)
Query: 54 AFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINL 113
AFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINL
Sbjct: 40 AFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINL 99
Query: 114 GPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMS 173
GPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMS
Sbjct: 100 GPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMS 159
Query: 174 ERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAE 233
ERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAE
Sbjct: 160 ERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAE 219
Query: 234 IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLA 293
IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLA
Sbjct: 220 IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLA 279
Query: 294 PEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSAR 353
PEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSAR
Sbjct: 280 PEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSAR 339
Query: 354 HLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 413
HLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF
Sbjct: 340 HLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 399
Query: 414 DPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 459
DPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
Sbjct: 400 DPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 445
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 833 bits (2152), Expect = 0.0
Identities = 406/406 (100%), Positives = 406/406 (100%)
Query: 54 AFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINL 113
AFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINL
Sbjct: 121 AFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINL 180
Query: 114 GPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMS 173
GPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMS
Sbjct: 181 GPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMS 240
Query: 174 ERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAE 233
ERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAE
Sbjct: 241 ERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAE 300
Query: 234 IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLA 293
IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLA
Sbjct: 301 IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLA 360
Query: 294 PEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSAR 353
PEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSAR
Sbjct: 361 PEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSAR 420
Query: 354 HLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 413
HLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF
Sbjct: 421 HLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 480
Query: 414 DPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 459
DPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
Sbjct: 481 DPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 526
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 569 bits (1466), Expect = e-162
Identities = 277/411 (67%), Positives = 330/411 (80%), Gaps = 13/411 (3%)
Query: 55 FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPP--------- 105
F+KQRR GLN+FIQ + HP+V++ L++ P+ ++PS
Sbjct: 86 FIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH----QSDPSEDEDERSSQKLH 141
Query: 106 SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKK 165
S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K + FYAVKVLQKK +L +
Sbjct: 142 STSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNR 201
Query: 166 KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEP 225
KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD++NGGELF+HLQRER F E
Sbjct: 202 KEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEH 261
Query: 226 RARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTF 285
RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VLTDFGLCKE I + TT+TF
Sbjct: 262 RARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTF 321
Query: 286 CGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK 345
CGTPEYLAPEV+ KQPYD TVDWWCLGAVLYEMLYGLPPFY R+ AEMYDNIL+KPL L+
Sbjct: 322 CGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLR 381
Query: 346 PNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 405
P ++ +A +LE LL+KDR RLGAK+DF+EI++H FF ++W DL+ KKI PPFNPNV+
Sbjct: 382 PGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVA 441
Query: 406 GPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTD 456
GP+D+R+FD FTEE VP S+ S D +V ASV EA +AF+GFSYAPP++
Sbjct: 442 GPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSE 492
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 569 bits (1466), Expect = e-162
Identities = 277/411 (67%), Positives = 330/411 (80%), Gaps = 13/411 (3%)
Query: 55 FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPP--------- 105
F+KQRR GLN+FIQ + HP+V++ L++ P+ ++PS
Sbjct: 86 FIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH----QSDPSEDEDERSSQKLH 141
Query: 106 SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKK 165
S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K + FYAVKVLQKK +L +
Sbjct: 142 STSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNR 201
Query: 166 KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEP 225
KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD++NGGELF+HLQRER F E
Sbjct: 202 KEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEH 261
Query: 226 RARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTF 285
RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VLTDFGLCKE I + TT+TF
Sbjct: 262 RARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTF 321
Query: 286 CGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK 345
CGTPEYLAPEV+ KQPYD TVDWWCLGAVLYEMLYGLPPFY R+ AEMYDNIL+KPL L+
Sbjct: 322 CGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLR 381
Query: 346 PNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 405
P ++ +A +LE LL+KDR RLGAK+DF+EI++H FF ++W DL+ KKI PPFNPNV+
Sbjct: 382 PGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVA 441
Query: 406 GPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTD 456
GP+D+R+FD FTEE VP S+ S D +V ASV EA +AF+GFSYAPP++
Sbjct: 442 GPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSE 492
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 546 bits (1408), Expect = e-155
Identities = 266/391 (68%), Positives = 321/391 (82%), Gaps = 14/391 (3%)
Query: 80 PEVQSILKISQPQEPEL------MNANPSPPPSPSQQ-----INLGPSSNPHAKPSDFHF 128
P ++ + P PEL MN++P+ PSP INLGPS+NP+A+P+DF F
Sbjct: 38 PPTPTLSCLLLPVPPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDF 97
Query: 129 LKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLV 188
LKVIGKG++GKVLLA+ K++ FYAVKVLQKK+ILKKKE+ HIM+ER+VLLKNV+HPFLV
Sbjct: 98 LKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLV 157
Query: 189 GLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVY 248
GL +SFQT +KLYFVLDY+NGGELF+HLQRER FLEPRARFYAAE+ASA+GYLHSLNI+Y
Sbjct: 158 GLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIY 217
Query: 249 RDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDW 308
RDLKPENILLD QGH+VLTDFGLCKE +E TTSTFCGTPEYLAPEVL K+PYDR VDW
Sbjct: 218 RDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDW 277
Query: 309 WCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL 368
WCLGAVLYEML+GLPPFYS++ ++MY+NIL++PLQ+ T +A LL+ LL KD+ +RL
Sbjct: 278 WCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRL 337
Query: 369 GAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGK 428
G+K DF+EIK+HVFFS INWDDL +K++TPPFNPNV+GP DL+HFDPEFT+E V SIG
Sbjct: 338 GSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGC 397
Query: 429 SPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 459
+PD+V AS A+ AFLGFSYAP D L
Sbjct: 398 TPDTV---ASSSGASSAFLGFSYAPEDDDIL 425
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 545 bits (1404), Expect = e-155
Identities = 261/368 (70%), Positives = 313/368 (85%), Gaps = 8/368 (2%)
Query: 97 MNANPSPPPSPSQQ-----INLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVF 151
MN++P+ PSP INLGPS+NP+A+P+DF FLKVIGKG++GKVLLA+ K++ F
Sbjct: 1 MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF 60
Query: 152 YAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGE 211
YAVKVLQKK+ILKKKE+ HIM+ER+VLLKNV+HPFLVGL +SFQT +KLYFVLDY+NGGE
Sbjct: 61 YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGE 120
Query: 212 LFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGL 271
LF+HLQRER FLEPRARFYAAE+ASA+GYLHSLNI+YRDLKPENILLD QGH+VLTDFGL
Sbjct: 121 LFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL 180
Query: 272 CKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTA 331
CKE +E TTSTFCGTPEYLAPEVL K+PYDR VDWWCLGAVLYEML+GLPPFYS++ +
Sbjct: 181 CKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVS 240
Query: 332 EMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDL 391
+MY+NIL++PLQ+ T +A LL+ LL KD+ +RLG+K DF+EIK+HVFFS INWDDL
Sbjct: 241 QMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDL 300
Query: 392 INKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 451
+K++TPPFNPNV+GP DL+HFDPEFT+E V SIG +PD+V AS A+ AFLGFSY
Sbjct: 301 YHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTV---ASSSGASSAFLGFSY 357
Query: 452 APPTDSFL 459
AP D L
Sbjct: 358 APEDDDIL 365
>gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [Homo
sapiens]
Length = 464
Score = 487 bits (1254), Expect = e-138
Identities = 248/411 (60%), Positives = 300/411 (72%), Gaps = 45/411 (10%)
Query: 55 FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPP--------- 105
F+KQRR GLN+FIQ + HP+V++ L++ P+ ++PS
Sbjct: 86 FIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH----QSDPSEDEDERSSQKLH 141
Query: 106 SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKK 165
S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K + FYAVKVLQKK +L +
Sbjct: 142 STSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNR 201
Query: 166 KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEP 225
KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD++NGGELF+HLQRER F E
Sbjct: 202 KEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEH 261
Query: 226 RARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTF 285
RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VLTDFGLCKE I + TT+TF
Sbjct: 262 RARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTF 321
Query: 286 CGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK 345
CGTPE PPFY R+ AEMYDNIL+KPL L+
Sbjct: 322 CGTPE--------------------------------PPFYCRDVAEMYDNILHKPLSLR 349
Query: 346 PNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 405
P ++ +A +LE LL+KDR RLGAK+DF+EI++H FF ++W DL+ KKI PPFNPNV+
Sbjct: 350 PGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVA 409
Query: 406 GPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTD 456
GP+D+R+FD FTEE VP S+ S D +V ASV EA +AF+GFSYAPP++
Sbjct: 410 GPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSE 460
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 350 bits (897), Expect = 2e-96
Identities = 179/374 (47%), Positives = 241/374 (64%), Gaps = 4/374 (1%)
Query: 82 VQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPS--DFHFLKVIGKGSFGK 139
+Q++ Q QE E MN +P+ + + S+ H + + DF +LK++GKG+FGK
Sbjct: 102 IQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGK 161
Query: 140 VLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADK 199
V+L R KA +YA+K+L+K+ I+ K E H ++E VL KN +HPFL L +SFQT D+
Sbjct: 162 VILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDR 220
Query: 200 LYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLD 259
L FV++Y+NGGELF+HL RER F E R RFY AEI SAL YLHS IVYRDLK EN++LD
Sbjct: 221 LCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLD 280
Query: 260 SQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 319
GHI +TDFGLCKE I +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+
Sbjct: 281 KDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 340
Query: 320 YGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIK 378
G PFY+++ ++++ IL + ++ +++ A+ LL GLL KD KRL G DD EI
Sbjct: 341 CGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIM 400
Query: 379 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTAS 438
H FFS +NW D+ +KK+ PPF P V+ D R+FD EFT + + + + D +
Sbjct: 401 RHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCM 460
Query: 439 VKEAAEAFLGFSYA 452
E F FSY+
Sbjct: 461 DNERRPHFPQFSYS 474
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 348 bits (893), Expect = 6e-96
Identities = 173/344 (50%), Positives = 231/344 (67%), Gaps = 4/344 (1%)
Query: 82 VQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPS--DFHFLKVIGKGSFGK 139
+Q++ Q QE E MN +P+ + + S+ H + + DF +LK++GKG+FGK
Sbjct: 102 IQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGK 161
Query: 140 VLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADK 199
V+L R KA +YA+K+L+K+ I+ K E H ++E VL KN +HPFL L +SFQT D+
Sbjct: 162 VILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDR 220
Query: 200 LYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLD 259
L FV++Y+NGGELF+HL RER F E R RFY AEI SAL YLHS IVYRDLK EN++LD
Sbjct: 221 LCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLD 280
Query: 260 SQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 319
GHI +TDFGLCKE I +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+
Sbjct: 281 KDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 340
Query: 320 YGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIK 378
G PFY+++ ++++ IL + ++ +++ A+ LL GLL KD KRL G DD EI
Sbjct: 341 CGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIM 400
Query: 379 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPV 422
H FFS +NW D+ +KK+ PPF P V+ D R+FD EFT + +
Sbjct: 401 RHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTI 444
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 329 bits (844), Expect = 3e-90
Identities = 168/344 (48%), Positives = 225/344 (65%), Gaps = 4/344 (1%)
Query: 82 VQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPS--DFHFLKVIGKGSFGK 139
V + LK P E + SP S + + S AK + DF +LK++GKG+FGK
Sbjct: 106 VANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGK 165
Query: 140 VLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADK 199
V+L R KA +YA+K+L+K+ I+ K E H ++E VL +N +HPFL L ++FQT D+
Sbjct: 166 VILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL-QNTRHPFLTALKYAFQTHDR 224
Query: 200 LYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLD 259
L FV++Y NGGELF+HL RER F E RARFY AEI SAL YLHS ++VYRD+K EN++LD
Sbjct: 225 LCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLD 284
Query: 260 SQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 319
GHI +TDFGLCKE I +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+
Sbjct: 285 KDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 344
Query: 320 YGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIK 378
G PFY+++ +++ IL + ++ ++ A+ LL GLL+KD +RL G D E+
Sbjct: 345 CGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVM 404
Query: 379 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPV 422
H FF INW D++ KK+ PPF P V+ D R+FD EFT + +
Sbjct: 405 EHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSI 448
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 326 bits (835), Expect = 3e-89
Identities = 172/370 (46%), Positives = 240/370 (64%), Gaps = 7/370 (1%)
Query: 86 LKISQPQEPELMNANPSPPPSPSQQINLGPSSNPH-AKPSDFHFLKVIGKGSFGKVLLAR 144
LK + +E + + +PS S ++++ + + H ++F +LK++GKG+FGKV+L +
Sbjct: 110 LKKQEEEEMDFRSGSPSDN-SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168
Query: 145 HKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVL 204
KA +YA+K+L+K+ I+ K E H ++E VL +N +HPFL L +SFQT D+L FV+
Sbjct: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVM 227
Query: 205 DYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRDLKPENILLDSQGH 263
+Y NGGELF+HL RER F E RARFY AEI SAL YLHS N+VYRDLK EN++LD GH
Sbjct: 228 EYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287
Query: 264 IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLP 323
I +TDFGLCKE I+ +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+ G
Sbjct: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347
Query: 324 PFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIKSHVF 382
PFY+++ ++++ IL + ++ + A+ LL GLL+KD +RL G +D EI H F
Sbjct: 348 PFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407
Query: 383 FSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEA 442
F+ I W + KK++PPF P V+ D R+FD EFT + + + DS+ S E
Sbjct: 408 FAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDS--ER 465
Query: 443 AEAFLGFSYA 452
F FSY+
Sbjct: 466 RPHFPQFSYS 475
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 326 bits (835), Expect = 3e-89
Identities = 172/370 (46%), Positives = 240/370 (64%), Gaps = 7/370 (1%)
Query: 86 LKISQPQEPELMNANPSPPPSPSQQINLGPSSNPH-AKPSDFHFLKVIGKGSFGKVLLAR 144
LK + +E + + +PS S ++++ + + H ++F +LK++GKG+FGKV+L +
Sbjct: 110 LKKQEEEEMDFRSGSPSDN-SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168
Query: 145 HKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVL 204
KA +YA+K+L+K+ I+ K E H ++E VL +N +HPFL L +SFQT D+L FV+
Sbjct: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVM 227
Query: 205 DYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRDLKPENILLDSQGH 263
+Y NGGELF+HL RER F E RARFY AEI SAL YLHS N+VYRDLK EN++LD GH
Sbjct: 228 EYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287
Query: 264 IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLP 323
I +TDFGLCKE I+ +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+ G
Sbjct: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347
Query: 324 PFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIKSHVF 382
PFY+++ ++++ IL + ++ + A+ LL GLL+KD +RL G +D EI H F
Sbjct: 348 PFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407
Query: 383 FSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEA 442
F+ I W + KK++PPF P V+ D R+FD EFT + + + DS+ S E
Sbjct: 408 FAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDS--ER 465
Query: 443 AEAFLGFSYA 452
F FSY+
Sbjct: 466 RPHFPQFSYS 475
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 326 bits (835), Expect = 3e-89
Identities = 172/370 (46%), Positives = 240/370 (64%), Gaps = 7/370 (1%)
Query: 86 LKISQPQEPELMNANPSPPPSPSQQINLGPSSNPH-AKPSDFHFLKVIGKGSFGKVLLAR 144
LK + +E + + +PS S ++++ + + H ++F +LK++GKG+FGKV+L +
Sbjct: 110 LKKQEEEEMDFRSGSPSDN-SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168
Query: 145 HKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVL 204
KA +YA+K+L+K+ I+ K E H ++E VL +N +HPFL L +SFQT D+L FV+
Sbjct: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVM 227
Query: 205 DYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRDLKPENILLDSQGH 263
+Y NGGELF+HL RER F E RARFY AEI SAL YLHS N+VYRDLK EN++LD GH
Sbjct: 228 EYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287
Query: 264 IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLP 323
I +TDFGLCKE I+ +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+ G
Sbjct: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347
Query: 324 PFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIKSHVF 382
PFY+++ ++++ IL + ++ + A+ LL GLL+KD +RL G +D EI H F
Sbjct: 348 PFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407
Query: 383 FSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEA 442
F+ I W + KK++PPF P V+ D R+FD EFT + + + DS+ S E
Sbjct: 408 FAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDS--ER 465
Query: 443 AEAFLGFSYA 452
F FSY+
Sbjct: 466 RPHFPQFSYS 475
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 308 bits (789), Expect = 7e-84
Identities = 163/351 (46%), Positives = 225/351 (64%), Gaps = 18/351 (5%)
Query: 111 INLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEE---VFYAVKVLQKKAILKK-K 166
+N GP +P F L+V+GKG +GKV R +A+KVL+K I++ K
Sbjct: 79 VNRGPEK---IRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK 135
Query: 167 EEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPR 226
+ H +ERN+L + VKHPF+V L ++FQT KLY +L+Y++GGELF L+RE F+E
Sbjct: 136 DTAHTKAERNIL-EEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDT 194
Query: 227 ARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFC 286
A FY AEI+ ALG+LH I+YRDLKPENI+L+ QGH+ LTDFGLCKE+I + T TFC
Sbjct: 195 ACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFC 254
Query: 287 GTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKP 346
GT EY+APE+L + ++R VDWW LGA++Y+ML G PPF N + D IL L L P
Sbjct: 255 GTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPP 314
Query: 347 NITNSARHLLEGLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 405
+T AR LL+ LL+++ RLGA D E+++H FF INW++L+ +K+ PPF P +
Sbjct: 315 YLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQ 374
Query: 406 GPNDLRHFDPEFTEE-PVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPT 455
D+ FD +FT + PV SPD ++ S A + FLGF+Y P+
Sbjct: 375 SEEDVSQFDSKFTRQTPV-----DSPDDSTLSES---ANQVFLGFTYVAPS 417
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 306 bits (785), Expect = 2e-83
Identities = 166/353 (47%), Positives = 228/353 (64%), Gaps = 22/353 (6%)
Query: 111 INLGPSS-NPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEV----FYAVKVLQKKAILKK 165
+N+GP PH F L+V+GKG +GKV R K + YA+KVL+K I++
Sbjct: 55 VNVGPERIGPHC----FELLRVLGKGGYGKVFQVR-KVQGTNLGKIYAMKVLRKAKIVRN 109
Query: 166 -KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLE 224
K+ H +ERN+L ++VKHPF+V L ++FQT KLY +L+ ++GGELF HL+RE FLE
Sbjct: 110 AKDTAHTRAERNIL-ESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLE 168
Query: 225 PRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTST 284
A FY AEI ALG+LHS I+YRDLKPENI+L SQGHI LTDFGLCKE+I + T T
Sbjct: 169 DTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHT 228
Query: 285 FCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQL 344
FCGT EY+APE+L + ++R VDWW LGA++Y+ML G PPF + N + D I+ L L
Sbjct: 229 FCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLAL 288
Query: 345 KPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPN 403
P +T AR L++ L+++ ++R+ G D +++ H FF +NWDDL+ ++ PPF P
Sbjct: 289 PPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPC 348
Query: 404 VSGPNDLRHFDPEFTEE-PVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPT 455
+ D+ FD FT + PV SPD TA + A +AFLGF+Y P+
Sbjct: 349 LQSEEDVSQFDTRFTRQTPV-----DSPDD---TALSESANQAFLGFTYVAPS 393
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 299 bits (766), Expect = 3e-81
Identities = 164/418 (39%), Positives = 241/418 (57%), Gaps = 29/418 (6%)
Query: 55 FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLG 114
FM G+++ ++ A+ Y + E + P+ E N ++ LG
Sbjct: 255 FMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELR---QKFEKAKLG 311
Query: 115 PSSNPHAKPS----------------DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQ 158
P+ N PS DF+FL V+GKGSFGKV+LA K E YA+K+L+
Sbjct: 312 PAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILK 371
Query: 159 KKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQR 218
K +++ + + M E+ VL K PFL LH FQT D+LYFV++Y+NGG+L YH+Q+
Sbjct: 372 KDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQ 431
Query: 219 ERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEH 278
F EP+A FYAAEI+ L +LH I+YRDLK +N++LDS+GHI + DFG+CKE++
Sbjct: 432 VGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMD 491
Query: 279 NSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNIL 338
TT TFCGTP+Y+APE++ QPY ++VDWW G +LYEML G PPF + E++ +I+
Sbjct: 492 GVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIM 551
Query: 339 NKPLQLKPNITNSARHLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKIT 397
+ +++ A + +GL+ K KRLG + +++ H FF I+W+ L N++I
Sbjct: 552 EHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQ 611
Query: 398 PPFNPNVSGPNDLRHFDPEFTE-EPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 454
PPF P V G +FD FT +PV +P LV A++ ++ F GFSY P
Sbjct: 612 PPFKPKVCG-KGAENFDKFFTRGQPV-----LTPPDQLVIANIDQS--DFEGFSYVNP 661
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 299 bits (765), Expect = 4e-81
Identities = 150/334 (44%), Positives = 210/334 (62%), Gaps = 7/334 (2%)
Query: 122 KPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKN 181
K +DF+FL V+GKGSFGKV+L+ K + YAVK+L+K +++ + + M E+ VL
Sbjct: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397
Query: 182 VKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYL 241
K PFL LH FQT D+LYFV++Y+NGG+L YH+Q+ F EP A FYAAEIA L +L
Sbjct: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457
Query: 242 HSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQP 301
S I+YRDLK +N++LDS+GHI + DFG+CKENI TT TFCGTP+Y+APE++ QP
Sbjct: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517
Query: 302 YDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQ 361
Y ++VDWW G +LYEML G PF + E++ +I+ + +++ A + +GL+
Sbjct: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMT 577
Query: 362 KDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 420
K KRLG + +IK H FF I+W+ L K+I PP+ P D +FD EFT +
Sbjct: 578 KHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQ 637
Query: 421 PVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 454
PV +P L ++ + F GFSY P
Sbjct: 638 PVE----LTPTDKLFIMNLDQ--NEFAGFSYTNP 665
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 296 bits (758), Expect = 3e-80
Identities = 152/332 (45%), Positives = 219/332 (65%), Gaps = 13/332 (3%)
Query: 125 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 184
+F+F+KV+GKGSFGKV+LA K ++ YAVKVL+K IL+ + M+E+ +L KH
Sbjct: 407 EFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKH 466
Query: 185 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 244
P+L L+ FQT D+L+FV++Y+NGG+L + +QR R F EPR+RFYAAE+ SAL +LH
Sbjct: 467 PYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQH 526
Query: 245 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 304
++YRDLK +NILLD++GH L DFG+CKE I + TT+TFCGTP+Y+APE+L + Y
Sbjct: 527 GVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGP 586
Query: 305 TVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDR 364
+VDWW LG ++YEM+ G PPF + N +++++IL+ + ++ A +L+ + K+
Sbjct: 587 SVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNP 646
Query: 365 TKRLG---AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFT-EE 420
KRLG +++ IK H FF I+W L KKI PPF P + D+ +FD +FT EE
Sbjct: 647 HKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREE 706
Query: 421 PVPNSIGKSPDSVLVTASVKEA-AEAFLGFSY 451
PV + + A VK+ E F GFSY
Sbjct: 707 PVLTLVDE--------AIVKQINQEEFKGFSY 730
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 294 bits (752), Expect = 1e-79
Identities = 154/374 (41%), Positives = 227/374 (60%), Gaps = 29/374 (7%)
Query: 92 QEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVF 151
+E E MN S S S + DF L+VIG+GS+ KVLL R K +
Sbjct: 232 EEKEAMNTRESGKASSSLGLQ------------DFDLLRVIGRGSYAKVLLVRLKKTDRI 279
Query: 152 YAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGE 211
YA+KV++K+ + ++ + +E++V + HPFLVGLH FQT +L+FV++Y+NGG+
Sbjct: 280 YAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGD 339
Query: 212 LFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGL 271
L +H+QR+R E ARFY+AEI+ AL YLH I+YRDLK +N+LLDS+GHI LTD+G+
Sbjct: 340 LMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGM 399
Query: 272 CKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPF------ 325
CKE + TTSTFCGTP Y+APE+L + Y +VDWW LG +++EM+ G PF
Sbjct: 400 CKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSS 459
Query: 326 --YSRNTAE-MYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGA--KDDFMEIKSH 380
+NT + ++ IL K +++ +++ A +L+ L KD +RLG + F +I+ H
Sbjct: 460 DNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGH 519
Query: 381 VFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVK 440
FF ++WD + K++ PPF PN+SG L +FD +FT EPV +PD + +
Sbjct: 520 PFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQ----LTPDDDDIVRKID 575
Query: 441 EAAEAFLGFSYAPP 454
++ F GF Y P
Sbjct: 576 QS--EFEGFEYINP 587
>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 289 bits (739), Expect = 4e-78
Identities = 147/339 (43%), Positives = 213/339 (62%), Gaps = 15/339 (4%)
Query: 125 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 184
DF ++VIG+GS+ KVLL R K + YA+KV++K+ + ++ + +E++V + +
Sbjct: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
Query: 185 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 244
PFLVGLH FQT +L+ V++Y+NGG+L +H+QR+R E ARFYAAEI AL +LH
Sbjct: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
Query: 245 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 304
I+YRDLK +N+LLD+ GHI LTD+G+CKE + TTSTFCGTP Y+APE+L + Y
Sbjct: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
Query: 305 TVDWWCLGAVLYEMLYGLPPF------YSRNTAE-MYDNILNKPLQLKPNITNSARHLLE 357
+VDWW LG +++EM+ G PF NT + ++ IL KP+++ ++ A H+L+
Sbjct: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
Query: 358 GLLQKDRTKRLGAKDD--FMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDP 415
G L KD +RLG + F +IKSH FF I+WD L K+ PPF P ++ L +FD
Sbjct: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
Query: 416 EFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 454
+FT EPV +PD + ++ F GF Y P
Sbjct: 368 QFTSEPVQ----LTPDDEDAIKRIDQS--EFEGFEYINP 400
>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 289 bits (739), Expect = 4e-78
Identities = 147/339 (43%), Positives = 213/339 (62%), Gaps = 15/339 (4%)
Query: 125 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 184
DF ++VIG+GS+ KVLL R K + YA+KV++K+ + ++ + +E++V + +
Sbjct: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
Query: 185 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 244
PFLVGLH FQT +L+ V++Y+NGG+L +H+QR+R E ARFYAAEI AL +LH
Sbjct: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
Query: 245 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 304
I+YRDLK +N+LLD+ GHI LTD+G+CKE + TTSTFCGTP Y+APE+L + Y
Sbjct: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
Query: 305 TVDWWCLGAVLYEMLYGLPPF------YSRNTAE-MYDNILNKPLQLKPNITNSARHLLE 357
+VDWW LG +++EM+ G PF NT + ++ IL KP+++ ++ A H+L+
Sbjct: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
Query: 358 GLLQKDRTKRLGAKDD--FMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDP 415
G L KD +RLG + F +IKSH FF I+WD L K+ PPF P ++ L +FD
Sbjct: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
Query: 416 EFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 454
+FT EPV +PD + ++ F GF Y P
Sbjct: 368 QFTSEPVQ----LTPDDEDAIKRIDQS--EFEGFEYINP 400
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 289 bits (739), Expect = 4e-78
Identities = 147/339 (43%), Positives = 213/339 (62%), Gaps = 15/339 (4%)
Query: 125 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 184
DF ++VIG+GS+ KVLL R K + YA+KV++K+ + ++ + +E++V + +
Sbjct: 251 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 310
Query: 185 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 244
PFLVGLH FQT +L+ V++Y+NGG+L +H+QR+R E ARFYAAEI AL +LH
Sbjct: 311 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 370
Query: 245 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 304
I+YRDLK +N+LLD+ GHI LTD+G+CKE + TTSTFCGTP Y+APE+L + Y
Sbjct: 371 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 430
Query: 305 TVDWWCLGAVLYEMLYGLPPF------YSRNTAE-MYDNILNKPLQLKPNITNSARHLLE 357
+VDWW LG +++EM+ G PF NT + ++ IL KP+++ ++ A H+L+
Sbjct: 431 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 490
Query: 358 GLLQKDRTKRLGAKDD--FMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDP 415
G L KD +RLG + F +IKSH FF I+WD L K+ PPF P ++ L +FD
Sbjct: 491 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 550
Query: 416 EFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 454
+FT EPV +PD + ++ F GF Y P
Sbjct: 551 QFTSEPVQ----LTPDDEDAIKRIDQS--EFEGFEYINP 583
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 288 bits (738), Expect = 5e-78
Identities = 159/387 (41%), Positives = 231/387 (59%), Gaps = 20/387 (5%)
Query: 76 ACKHP-EVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNP-HAKPSDFHFLKVIG 133
AC +P E+ +++ P PSP PSP+ ++P SDF FL V+G
Sbjct: 304 ACNYPLELYERVRMGPSSSPI-----PSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLG 358
Query: 134 KGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP-----FLV 188
KGSFGKV+LA + + YA+K+L+K I++ + + E+ VL + P FL
Sbjct: 359 KGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLT 418
Query: 189 GLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVY 248
LH +FQT D+LYFV++Y+ GG+L YH+Q+ F EP A FYAAEIA L +LH+ I+Y
Sbjct: 419 QLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIY 478
Query: 249 RDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDW 308
RDLK +N++LD++GHI +TDFG+CKEN+ +TT TFCGTP+Y+APE++ QPY ++VDW
Sbjct: 479 RDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDW 538
Query: 309 WCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL 368
W G +LYEML G PPF + E++ I+ + + +++ A + +G L K KRL
Sbjct: 539 WSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRL 598
Query: 369 GA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIG 427
G+ D I++H FF I+W+ L +I PPF P G + +FD FT +
Sbjct: 599 GSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSG-ENFDKFFTRA----APA 653
Query: 428 KSPDSVLVTASVKEAAEAFLGFSYAPP 454
+P LV AS+ +A F GF+Y P
Sbjct: 654 LTPPDRLVLASIDQA--DFQGFTYVNP 678
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 287 bits (735), Expect = 1e-77
Identities = 141/301 (46%), Positives = 196/301 (65%), Gaps = 2/301 (0%)
Query: 122 KPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKN 181
K +DF+FL V+GKGSFGKV+L+ K + YAVK+L+K +++ + + M E+ VL
Sbjct: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397
Query: 182 VKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYL 241
K PFL LH FQT D+LYFV++Y+NGG+L YH+Q+ F EP A FYAAEIA L +L
Sbjct: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457
Query: 242 HSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQP 301
S I+YRDLK +N++LDS+GHI + DFG+CKENI TT TFCGTP+Y+APE++ QP
Sbjct: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517
Query: 302 YDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQ 361
Y ++VDWW G +LYEML G PF + E++ +I+ + +++ A + +GL+
Sbjct: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMT 577
Query: 362 KDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 420
K KRLG + +IK H FF I+W+ L K+I PP+ P G N +FD FT
Sbjct: 578 KHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRN-AENFDRFFTRH 636
Query: 421 P 421
P
Sbjct: 637 P 637
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 286 bits (731), Expect = 4e-77
Identities = 150/345 (43%), Positives = 213/345 (61%), Gaps = 10/345 (2%)
Query: 113 LGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIM 172
+G +S+ +F F++V+GKGSFGKV+LAR K YAVKVL+K IL+ + + M
Sbjct: 342 IGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTM 401
Query: 173 SERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAA 232
+E+ +L HPFL L FQT D+L+FV++++NGG+L +H+Q+ R F E RARFYAA
Sbjct: 402 TEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAA 461
Query: 233 EIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYL 292
EI SAL +LH I+YRDLK +N+LLD +GH L DFG+CKE I + TT+TFCGTP+Y+
Sbjct: 462 EIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYI 521
Query: 293 APEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSA 352
APE+L + Y VDWW +G +LYEML G PF + N ++++ ILN + + A
Sbjct: 522 APEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDA 581
Query: 353 RHLLEGLLQKDRTKRLGAKDDFME--IKSHVFFSLINWDDLINKKITPPFNPNVSGPNDL 410
+L+ + K+ T RLG+ E I H FF I+W L +++I PPF P + D+
Sbjct: 582 TGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDV 641
Query: 411 RHFDPEF-TEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 454
+FDP+F EEPV I + ++ + F FSY P
Sbjct: 642 SNFDPDFIKEEPVLTPIDEGHLPMI-------NQDEFRNFSYVSP 679
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 284 bits (727), Expect = 1e-76
Identities = 153/339 (45%), Positives = 210/339 (61%), Gaps = 14/339 (4%)
Query: 121 AKPSDFHFLKVIGKGSFGKVLLARHKA---EEVFYAVKVLQKKAILKKKEEKHIMSERNV 177
A PS F LKV+G+GSFGKV L + + YA+KVL KKA LK ++ ER++
Sbjct: 63 ADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVL-KKATLKVRDRVRTKMERDI 121
Query: 178 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 237
L++ V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 122 LVE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 180
Query: 238 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 297
L +LHSL I+YRDLKPENILLD +GHI LTDFGL KE+I+H +FCGT EY+APEV+
Sbjct: 181 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 240
Query: 298 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 357
+++ + ++ DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 241 NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLR 300
Query: 358 GLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 416
L +++ RLGA D EIK H FFS I+W+ L ++I PPF P P D +FDPE
Sbjct: 301 MLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPE 360
Query: 417 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPT 455
FT + +S G P + A + F GFS+ T
Sbjct: 361 FTAKTPKDSPGIPPSA--------NAHQLFRGFSFVAIT 391
Score = 118 bits (296), Expect = 1e-26
Identities = 91/310 (29%), Positives = 146/310 (47%), Gaps = 25/310 (8%)
Query: 132 IGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLH 191
IG GS+ HKA + +AVK++ K ++ E +LL+ +HP ++ L
Sbjct: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKS-------KRDPTEEIEILLRYGQHPNIITLK 480
Query: 192 FSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDL 251
+ +Y V + + GGEL + R++ F E A I + YLH+ +V+RDL
Sbjct: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540
Query: 252 KPENIL-LDSQGH---IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVD 307
KP NIL +D G+ I + DFG K+ N T C T ++APEVL +Q YD D
Sbjct: 541 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACD 600
Query: 308 WWCLGAVLYEMLYGLPPFYS---RNTAEMYDNILNKPLQLK----PNITNSARHLLEGLL 360
W LG +LY ML G PF + E+ I + L +++++A+ L+ +L
Sbjct: 601 IWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKML 660
Query: 361 QKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPN-VSGPNDLRHFDPEFTE 419
D +RL A + H + +++WD L ++ P+ V G + +
Sbjct: 661 HVDPHQRLTA----ALVLRHPW--IVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQ 714
Query: 420 EPVPNSIGKS 429
PV +G+S
Sbjct: 715 SPVLEPVGRS 724
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 283 bits (725), Expect = 2e-76
Identities = 154/335 (45%), Positives = 207/335 (61%), Gaps = 14/335 (4%)
Query: 121 AKPSDFHFLKVIGKGSFGKVLLARH-KAEEV--FYAVKVLQKKAILKKKEEKHIMSERNV 177
A PS F LKV+G+GS+GKV L R K + YA+KVL KKA LK ++ ER++
Sbjct: 62 ADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKMERDI 120
Query: 178 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 237
L + V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 121 LAE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 179
Query: 238 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 297
L +LHSL I+YRDLKPENILLD +GHI +TDFGL KE I+H+ +FCGT EY+APEV+
Sbjct: 180 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 239
Query: 298 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 357
+++ + ++ DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 240 NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLR 299
Query: 358 GLLQKDRTKRLGAK-DDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 416
L +++ RLGA D EIK H FF I+W+ L K+I PPF P V P D HFDPE
Sbjct: 300 ALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPE 359
Query: 417 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 451
FT +S G P + A F GFS+
Sbjct: 360 FTARTPTDSPGVPPSA--------NAHHLFRGFSF 386
Score = 121 bits (303), Expect = 2e-27
Identities = 83/246 (33%), Positives = 118/246 (47%), Gaps = 15/246 (6%)
Query: 84 SILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLA 143
S + S QEP + + P QQ++ +N H + + IG GS+
Sbjct: 385 SFVASSLIQEPSQQDLHKVPVHPIVQQLH---GNNIHFTDG-YEIKEDIGVGSYSVCKRC 440
Query: 144 RHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFV 203
HKA + YAVK++ K ++ E +LL+ +HP ++ L + +Y V
Sbjct: 441 VHKATDTEYAVKIIDKS-------KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLV 493
Query: 204 LDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILL-DSQG 262
++ + GGEL + R+R F E A I + YLHS +V+RDLKP NIL D G
Sbjct: 494 MELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESG 553
Query: 263 ---HIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 319
I + DFG K+ N T C T ++APEVL +Q YD D W LG +LY ML
Sbjct: 554 SPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTML 613
Query: 320 YGLPPF 325
G PF
Sbjct: 614 AGFTPF 619
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 283 bits (725), Expect = 2e-76
Identities = 154/335 (45%), Positives = 207/335 (61%), Gaps = 14/335 (4%)
Query: 121 AKPSDFHFLKVIGKGSFGKVLLARH-KAEEV--FYAVKVLQKKAILKKKEEKHIMSERNV 177
A PS F LKV+G+GS+GKV L R K + YA+KVL KKA LK ++ ER++
Sbjct: 54 ADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKMERDI 112
Query: 178 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 237
L + V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 113 LAE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 171
Query: 238 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 297
L +LHSL I+YRDLKPENILLD +GHI +TDFGL KE I+H+ +FCGT EY+APEV+
Sbjct: 172 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 231
Query: 298 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 357
+++ + ++ DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 232 NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLR 291
Query: 358 GLLQKDRTKRLGAK-DDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 416
L +++ RLGA D EIK H FF I+W+ L K+I PPF P V P D HFDPE
Sbjct: 292 ALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPE 351
Query: 417 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 451
FT +S G P + A F GFS+
Sbjct: 352 FTARTPTDSPGVPPSA--------NAHHLFRGFSF 378
Score = 121 bits (303), Expect = 2e-27
Identities = 83/246 (33%), Positives = 118/246 (47%), Gaps = 15/246 (6%)
Query: 84 SILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLA 143
S + S QEP + + P QQ++ +N H + + IG GS+
Sbjct: 377 SFVASSLIQEPSQQDLHKVPVHPIVQQLH---GNNIHFTDG-YEIKEDIGVGSYSVCKRC 432
Query: 144 RHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFV 203
HKA + YAVK++ K ++ E +LL+ +HP ++ L + +Y V
Sbjct: 433 VHKATDTEYAVKIIDKS-------KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLV 485
Query: 204 LDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILL-DSQG 262
++ + GGEL + R+R F E A I + YLHS +V+RDLKP NIL D G
Sbjct: 486 MELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESG 545
Query: 263 ---HIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 319
I + DFG K+ N T C T ++APEVL +Q YD D W LG +LY ML
Sbjct: 546 SPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTML 605
Query: 320 YGLPPF 325
G PF
Sbjct: 606 AGFTPF 611
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,514,713
Number of Sequences: 37866
Number of extensions: 959445
Number of successful extensions: 7219
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 726
Number of HSP's successfully gapped in prelim test: 113
Number of HSP's that attempted gapping in prelim test: 4709
Number of HSP's gapped (non-prelim): 1146
length of query: 459
length of database: 18,247,518
effective HSP length: 106
effective length of query: 353
effective length of database: 14,233,722
effective search space: 5024503866
effective search space used: 5024503866
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.