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Search of human proteins with 217416398
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|217416398 hyaluronan-mediated motility receptor isoform c
[Homo sapiens]
(709 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|217416398 hyaluronan-mediated motility receptor isoform c [Ho... 1358 0.0
gi|217416394 hyaluronan-mediated motility receptor isoform b [Ho... 1348 0.0
gi|217272802 hyaluronan-mediated motility receptor isoform a [Ho... 1348 0.0
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho... 1211 0.0
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 132 1e-30
gi|9910266 kinesin family member 15 [Homo sapiens] 131 2e-30
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 127 5e-29
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 123 7e-28
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 122 1e-27
gi|156104908 myosin heavy chain 6 [Homo sapiens] 122 1e-27
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 119 1e-26
gi|38044112 restin isoform b [Homo sapiens] 119 1e-26
gi|4506751 restin isoform a [Homo sapiens] 119 1e-26
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 118 2e-26
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 117 4e-26
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 117 5e-26
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 116 6e-26
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 116 6e-26
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 116 6e-26
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 116 8e-26
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 116 8e-26
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 116 8e-26
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 116 8e-26
gi|31982906 cingulin-like 1 [Homo sapiens] 115 2e-25
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 114 2e-25
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 113 5e-25
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 112 1e-24
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 111 2e-24
gi|34577114 cytomatrix protein p110 [Homo sapiens] 111 3e-24
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 110 3e-24
>gi|217416398 hyaluronan-mediated motility receptor isoform c [Homo
sapiens]
Length = 709
Score = 1358 bits (3516), Expect = 0.0
Identities = 709/709 (100%), Positives = 709/709 (100%)
Query: 1 MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT 60
MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT
Sbjct: 1 MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT 60
Query: 61 TLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNAT 120
TLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNAT
Sbjct: 61 TLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNAT 120
Query: 121 LEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKL 180
LEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKL
Sbjct: 121 LEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKL 180
Query: 181 QVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIA 240
QVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIA
Sbjct: 181 QVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIA 240
Query: 241 QLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLN 300
QLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLN
Sbjct: 241 QLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLN 300
Query: 301 AEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFE 360
AEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFE
Sbjct: 301 AEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFE 360
Query: 361 EELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHT 420
EELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHT
Sbjct: 361 EELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHT 420
Query: 421 QATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQ 480
QATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQ
Sbjct: 421 QATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQ 480
Query: 481 HQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQL 540
HQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQL
Sbjct: 481 HQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQL 540
Query: 541 EDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQ 600
EDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQ
Sbjct: 541 EDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQ 600
Query: 601 EQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEE 660
EQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEE
Sbjct: 601 EQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEE 660
Query: 661 LNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQESWK 709
LNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQESWK
Sbjct: 661 LNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQESWK 709
>gi|217416394 hyaluronan-mediated motility receptor isoform b [Homo
sapiens]
Length = 724
Score = 1348 bits (3490), Expect = 0.0
Identities = 709/724 (97%), Positives = 709/724 (97%), Gaps = 15/724 (2%)
Query: 1 MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT 60
MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT
Sbjct: 1 MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT 60
Query: 61 TLPASARKVKSSESK---------------IRVLLQERGAQDRRIQDLETELEKMEARLN 105
TLPASARKVKSSESK IRVLLQERGAQDRRIQDLETELEKMEARLN
Sbjct: 61 TLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLN 120
Query: 106 AALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETK 165
AALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETK
Sbjct: 121 AALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETK 180
Query: 166 MRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI 225
MRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI
Sbjct: 181 MRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI 240
Query: 226 SCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK 285
SCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK
Sbjct: 241 SCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK 300
Query: 286 EDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKL 345
EDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKL
Sbjct: 301 EDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKL 360
Query: 346 CSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKL 405
CSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKL
Sbjct: 361 CSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKL 420
Query: 406 KGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSL 465
KGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSL
Sbjct: 421 KGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSL 480
Query: 466 QEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDL 525
QEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDL
Sbjct: 481 QEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDL 540
Query: 526 QNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF 585
QNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF
Sbjct: 541 QNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF 600
Query: 586 EVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRC 645
EVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRC
Sbjct: 601 EVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRC 660
Query: 646 QLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQ 705
QLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQ
Sbjct: 661 QLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQ 720
Query: 706 ESWK 709
ESWK
Sbjct: 721 ESWK 724
>gi|217272802 hyaluronan-mediated motility receptor isoform a [Homo
sapiens]
Length = 725
Score = 1348 bits (3489), Expect = 0.0
Identities = 709/725 (97%), Positives = 709/725 (97%), Gaps = 16/725 (2%)
Query: 1 MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT 60
MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT
Sbjct: 1 MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT 60
Query: 61 TLPASARKVKSSESK----------------IRVLLQERGAQDRRIQDLETELEKMEARL 104
TLPASARKVKSSESK IRVLLQERGAQDRRIQDLETELEKMEARL
Sbjct: 61 TLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARL 120
Query: 105 NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET 164
NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET
Sbjct: 121 NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET 180
Query: 165 KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE 224
KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE
Sbjct: 181 KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE 240
Query: 225 ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE 284
ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE
Sbjct: 241 ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE 300
Query: 285 KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 344
KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK
Sbjct: 301 KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 360
Query: 345 LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 404
LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK
Sbjct: 361 LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 420
Query: 405 LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS 464
LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS
Sbjct: 421 LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS 480
Query: 465 LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 524
LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD
Sbjct: 481 LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 540
Query: 525 LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA 584
LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA
Sbjct: 541 LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA 600
Query: 585 FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR 644
FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR
Sbjct: 601 FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR 660
Query: 645 CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMEC 704
CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMEC
Sbjct: 661 CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMEC 720
Query: 705 QESWK 709
QESWK
Sbjct: 721 QESWK 725
>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
sapiens]
Length = 638
Score = 1211 bits (3132), Expect = 0.0
Identities = 634/634 (100%), Positives = 634/634 (100%)
Query: 76 IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL 135
IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL
Sbjct: 5 IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL 64
Query: 136 KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA 195
KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA
Sbjct: 65 KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA 124
Query: 196 QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 255
QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS
Sbjct: 125 QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 184
Query: 256 LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ 315
LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ
Sbjct: 185 LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ 244
Query: 316 EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQ 375
EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQ
Sbjct: 245 EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQ 304
Query: 376 KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 435
KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ
Sbjct: 305 KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 364
Query: 436 SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR 495
SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR
Sbjct: 365 SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR 424
Query: 496 MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA 555
MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA
Sbjct: 425 MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA 484
Query: 556 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG 615
ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG
Sbjct: 485 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG 544
Query: 616 HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKA 675
HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKA
Sbjct: 545 HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKA 604
Query: 676 FHHESKENFALKTPLKEGNTNCYRAPMECQESWK 709
FHHESKENFALKTPLKEGNTNCYRAPMECQESWK
Sbjct: 605 FHHESKENFALKTPLKEGNTNCYRAPMECQESWK 638
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 132 bits (332), Expect = 1e-30
Identities = 162/691 (23%), Positives = 312/691 (45%), Gaps = 71/691 (10%)
Query: 36 VSFQKSQ----RFKQQKESKQNLNVDKDTTLPASARKVKS-SESKIRVLLQERGAQDRRI 90
V+ +KSQ + Q+KE +++L +++ L + + + SE+K+R L QE RI
Sbjct: 513 VALEKSQSEYLKISQEKEQQESLALEE---LELQKKAILTESENKLRDLQQEAETYRTRI 569
Query: 91 QDLETELEK-MEARLNAALREKTSLSANNATLEKQL---IELTRTN-ELLKSKFSENGNQ 145
+LE+ LEK ++ N + L A K++ +E +T E LK + +
Sbjct: 570 LELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTE 629
Query: 146 KNLRILS----LELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGK-IAQLEGK 200
K L++L E+ KLR K E + ++ +E + Q +EE K + +L+ K
Sbjct: 630 K-LQVLKQQYQTEMEKLREKCEQEKETLLKDKE------IIFQAHIEEMNEKTLEKLDVK 682
Query: 201 LVSIEK--EKIDEKSETEKLLEYIEEISCASDQVEKYKLDI-AQLEENLKEKNDEILSLK 257
+E ++ E + LE EE+S DQ +K K ++ A+++E ++ S+
Sbjct: 683 QTELESLSSELSEVLKARHKLE--EELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSII 740
Query: 258 QSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQER 317
+ E +I K ++D + +LL KE++ H+ ++ H ENL A+++ + + +
Sbjct: 741 KEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKL 800
Query: 318 EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKE 377
+ Q + + +E + L QKL + E + E Q D +L +
Sbjct: 801 DVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHK 860
Query: 378 EQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSL 437
Q + L++QLE++ +++K L + E++LE + Q +L EK + ++Q
Sbjct: 861 IQVQDLMQQLEKQNSEMEQKVKSLTQVY---ESKLEDGNKEQEQTKQILVEKENMILQMR 917
Query: 438 E-----------DVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILAT 486
E ++A+ +S L K + +++ KA + E ++ ++L
Sbjct: 918 EGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQ 977
Query: 487 ESS-NQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEED--------FR 537
E+ +E L+L K ++ E+ + I+D ++L+ +++ R
Sbjct: 978 EAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHR 1037
Query: 538 KQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQAL----- 592
++L D +K N AE +EI++ +L +E + + ++ F EK+ +
Sbjct: 1038 RELNDVISIWEKKLNQQAEELQEIHEIQL--QEKEQEVAELKQKILLFGCEKEEMNKEIT 1095
Query: 593 -LNEHGAAQE-QLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKK 650
L E G Q+ LN+++ + LKQK HV L + ++LK+ + KL L K
Sbjct: 1096 WLKEEGVKQDTTLNELQ---------EQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKS 1146
Query: 651 KQSETKLQEELNKVLGIKHFDPSKAFHHESK 681
+ T LQE+L ++ + D K SK
Sbjct: 1147 LKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
Score = 112 bits (279), Expect = 2e-24
Identities = 166/742 (22%), Positives = 317/742 (42%), Gaps = 111/742 (14%)
Query: 17 CAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKI 76
C + + KT E++ +S K+ + Q+ L V E+++
Sbjct: 1221 CKKTEALLEAKTNELIN--ISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQL 1278
Query: 77 RVLLQERGAQD-------RRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELT 129
R L +E+ + ++++ E +++ M+A + + + EK +L ++ E
Sbjct: 1279 RQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKE 1338
Query: 130 RTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLE- 188
LK + SEN N ++ LMK K + K E + Q+T +++
Sbjct: 1339 SCITQLKKELSENIN-------AVTLMKEELKEK--------KVEISSLSKQLTDLNVQL 1383
Query: 189 ESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKE 248
++ +++ E + S+ K+ +EK E LL+ ++++S D + K K+ + ++
Sbjct: 1384 QNSISLSEKEAAISSLRKQYDEEKCE---LLDQVQDLSFKVDTLSKEKISALEQVDDWSN 1440
Query: 249 KNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE---KEDHVNRNREHNENLNAEMQN 305
K E K+ + V++L ++ +L KE K++ +N +E + N
Sbjct: 1441 KFSE---WKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDC 1497
Query: 306 LKQKFILEQQEREKLQQKELQIDSLLQQEK----ELSSSLHQKLCSFQE--EMVK----E 355
LK + + ++ K+++KE +++ L+ + EL + QK + E++K +
Sbjct: 1498 LKGEM---EDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQ 1554
Query: 356 KNLFEEELKQTLDELDKLQQKEE----QAERLVKQLEEEAKSRAEEL------------- 398
K++ +EL Q L +L ++++ +AE + LE + S EL
Sbjct: 1555 KDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLS 1614
Query: 399 -KLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMV--QSLEDVTAQFESYKALTASEI 455
K EE+LK E LE SAA E+ + + Q L + + E YK T S +
Sbjct: 1615 VKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHL 1674
Query: 456 EDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKE-- 513
+L N+ LQE+ + ++ ++ + ESS E +++ K+ TE +E
Sbjct: 1675 SEL---NTKLQERE----REVHILEEKLKSVESSQSE--TLIVPRSAKNVAAYTEQEEAD 1725
Query: 514 ----ITVSFLQKITDLQNQLKQQEEDFRKQLEDEE--------------GRKAEKENTTA 555
+ ++ +KI+ LQ L ++E+ ++ +++E R + E+ A
Sbjct: 1726 SQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEA 1785
Query: 556 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKL-- 613
+ E+ + L EEL K K + L + A VEK+ N A Q N D L
Sbjct: 1786 KQHEDQSMIGHLQEELEEKNKKYSL-IVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQE 1844
Query: 614 --LGHQNLKQKIKH----VVKLKD----ENSQLKSEVSKLRC-QLAKKKQSETKLQEELN 662
L Q L+QKIK +V+ K+ E +L S+ KL+ Q + T+L EE
Sbjct: 1845 KELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENT 1904
Query: 663 KVLGIKHF-DPSKAFHHESKEN 683
+ H P + E++ N
Sbjct: 1905 EEKSKSHLVQPKLLSNMEAQHN 1926
Score = 97.8 bits (242), Expect = 3e-20
Identities = 152/678 (22%), Positives = 278/678 (41%), Gaps = 99/678 (14%)
Query: 75 KIRVLLQERGAQDRRIQDLETELEKMEARLNAALRE-KTSLSANNATLEKQLIELTRTNE 133
K ++LQ R Q + I+ L +L E ++ E +T +EK + E
Sbjct: 909 KENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQE 968
Query: 134 LLKSKF--SENGNQKNLRILSLELMKLRNKRETKMRGM-MAKQEGME---MKLQVTQRSL 187
LK K E +K L +LEL + + KM M A G+ +L+ Q+
Sbjct: 969 TLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQ 1028
Query: 188 EESQGKIAQLE-GKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENL 246
ES ++ + E ++SI ++K+++++E L+ I EI Q+++ + ++A+L++ +
Sbjct: 1029 IESLTEVHRRELNDVISIWEKKLNQQAEE---LQEIHEI-----QLQEKEQEVAELKQKI 1080
Query: 247 -------KEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENL 299
+E N EI LK+ + L++ E L K+K HVN + L
Sbjct: 1081 LLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQL--------KQKSAHVNSLAQDETKL 1132
Query: 300 NAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLF 359
A ++ L+ +E LQ++ +++ L +++K S L KL + EE K+
Sbjct: 1133 KAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSH 1192
Query: 360 EEELKQTLDE-LDKLQQKEEQAERL---VKQLEEEAKSRAEELKLLEEK----------- 404
E+ K D+ L+ + EE A +L K+ E +++ EL +
Sbjct: 1193 EKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISH 1252
Query: 405 -----LKGKEA---------ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKAL 450
K KEA ELE T+ L + LE+ Q +S KA
Sbjct: 1253 CQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKA- 1311
Query: 451 TASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETE 510
+IE L E +LQ++ + A + + I + E + + ++ + K+ E
Sbjct: 1312 ---DIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVE 1368
Query: 511 IKEITVSFLQKITDLQNQLKQQEED-----FRKQLEDEEGRKAE-------------KEN 552
I ++ LQN + E++ RKQ ++E+ + KE
Sbjct: 1369 ISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEK 1428
Query: 553 TTAELTEEINKWRLLYEEL-----------YNKTKPFQLQLDAFEVEKQALLNEHGAAQE 601
+A E+++ W + E N K Q+QL+ E + +E
Sbjct: 1429 ISA--LEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKE 1486
Query: 602 QLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEEL 661
+L++ + L G K K K + ++LKS+ +++ +L +T E L
Sbjct: 1487 ELDQQNKRFDCLKGEME-DDKSKMEKKESNLETELKSQTARI-MELEDHITQKTIEIESL 1544
Query: 662 NKVLGIKHFDPSKAFHHE 679
N+VL K+++ K H+
Sbjct: 1545 NEVL--KNYNQQKDIEHK 1560
Score = 90.5 bits (223), Expect = 5e-18
Identities = 143/675 (21%), Positives = 294/675 (43%), Gaps = 106/675 (15%)
Query: 68 KVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIE 127
+ S ES R+ L A D+++E E + S S N L ++L
Sbjct: 95 RTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGN---------SDSLNKEQLIQRLRR 145
Query: 128 LTRTNELLKSKFSENGNQKNLRILSLELMKLRN----KRETKMRGMMAKQEGMEMKLQVT 183
+ R+ + K+SE ++L E KL+ ++ +R + +E ++M Q
Sbjct: 146 MERSLSSYRGKYSELVTA--YQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAK 203
Query: 184 QR-------SLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYK 236
+ SLEE I+ L+ + VS+ K+++ +L+ + ++ ++ K +
Sbjct: 204 KHLQEEFDASLEEKDQYISVLQTQ-VSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEE 262
Query: 237 LDIAQ----LEENLKEKNDEILSLKQSLEENIVILSKQ-VEDLNVKCQLLEKEKEDHVNR 291
+ +E+ K E L + +EN++ K+ ++ +C LL EKE
Sbjct: 263 NPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKE----- 317
Query: 292 NREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEK--------ELSSSLHQ 343
E L+ +Q L++ L E+ KL + +L++Q + E +H+
Sbjct: 318 --ALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHE 375
Query: 344 KLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEE 403
L +EE+ + ++ +KQ + ++L++++E++ER + E+A S A++ +
Sbjct: 376 TLEMKEEEIAQLRS----RIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARR 431
Query: 404 KLKGKEAE----LEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLK 459
KLK + E +EK+S + + LQ++ + Q + DV + + ++ + +
Sbjct: 432 KLKAEMDEQIKTIEKTSE---EERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKE 488
Query: 460 LENSSLQEKAAKAGKNAEDVQHQI-LATESSNQEYVRML-------------LDLQTKSA 505
L QE K + Q Q+ +A E S EY+++ L+LQ K+
Sbjct: 489 LARKE-QELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAI 547
Query: 506 LKETE-----IKEITVSFLQKITDLQNQLKQQEEDFRKQLED-EEGRKAEKENTTAELTE 559
L E+E +++ ++ +I +L++ L++ ++ + Q +D +AEK E+T
Sbjct: 548 LTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITV 607
Query: 560 EINKWRLLYEELYNK-----TKPFQLQLDAFEVEKQALLNEHGAAQEQLNK--------- 605
+ K + E L ++ T+ Q+ ++ E + L + +E L K
Sbjct: 608 MVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAH 667
Query: 606 IRDSYAKLLGHQNLKQ--------------KIKHVVKLKDENSQLKSEVSKLRCQL-AKK 650
I + K L ++KQ K +H KL++E S LK + K++ +L AK
Sbjct: 668 IEEMNEKTLEKLDVKQTELESLSSELSEVLKARH--KLEEELSVLKDQTDKMKQELEAKM 725
Query: 651 KQSETKLQEELNKVL 665
+ + Q++++ ++
Sbjct: 726 DEQKNHHQQQVDSII 740
Score = 75.9 bits (185), Expect = 1e-13
Identities = 132/602 (21%), Positives = 249/602 (41%), Gaps = 123/602 (20%)
Query: 29 LEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQ-- 86
+ +K + Q ++ +Q K+ ++ + +T L R+V E K++ + +
Sbjct: 1648 IAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLI 1707
Query: 87 -DRRIQDLETELEKMEARLNAALR----EKTSLSANNATLEKQLIE-LTRTNELLKSKFS 140
R +++ E+ EA ++ EK S+ N T +++L++ + + E S
Sbjct: 1708 VPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHF 1767
Query: 141 ENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQ----VTQRSLEESQGKI-- 194
E Q R++ LE + + + M G + QE +E K + + + +E+ GK
Sbjct: 1768 EMRCQYQERLIKLEHAEAKQHEDQSMIGHL--QEELEEKNKKYSLIVAQHVEKEGGKNNI 1825
Query: 195 ---AQLEGKLVSIEKEKIDEKSETEKLLEY-IEEI-SCASDQVEKYKLDIAQLEENLKEK 249
LE ++K + EK T ++LE I+E+ SC Q E +++++ E L K
Sbjct: 1826 QAKQNLENVFDDVQKT-LQEKELTCQILEQKIKELDSCLVRQKEVHRVEM----EELTSK 1880
Query: 250 NDEILSLKQS---------LEENIVILSK--------------QVEDLNVKCQLLEKEKE 286
+++ +L+Q LEEN SK Q DL K E+EK+
Sbjct: 1881 YEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQ 1940
Query: 287 -----------DHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQID------- 328
D +EH + E++ LK+++ E++E+ K +Q++L++
Sbjct: 1941 KLGKEIVRLQKDLRMLRKEHQQ----ELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQ 1996
Query: 329 -------SLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAE 381
L Q+E+EL ++ + + QE E L E ++T L K+ +K++ +
Sbjct: 1997 LMREFNTQLAQKEQELEMTIKETINKAQEV---EAELLESHQEETNQLLKKIAEKDDDLK 2053
Query: 382 RLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLED-- 439
R K+ EE +R EE + K++ + +LE+ LQ+KY ++ E+
Sbjct: 2054 RTAKRYEEILDAREEE---MTAKVRDLQTQLEE-----------LQKKYQQKLEQEENPG 2099
Query: 440 ----VTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILAT--------- 486
+ ++ A + I D KL+ +E+ + + + AT
Sbjct: 2100 NDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTPYKGG 2159
Query: 487 -----------ESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEED 535
E + EY+R +L +T K IT + K D Q Q + ED
Sbjct: 2160 NLYHTDVSLFGEPTEFEYLRKVLFEYMMGRETKTMAKVITT--VLKFPDDQTQKILERED 2217
Query: 536 FR 537
R
Sbjct: 2218 AR 2219
>gi|9910266 kinesin family member 15 [Homo sapiens]
Length = 1388
Score = 131 bits (330), Expect = 2e-30
Identities = 149/684 (21%), Positives = 296/684 (43%), Gaps = 110/684 (16%)
Query: 67 RKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAAL--------REKTSLSANN 118
R V+ S ++ L E ++ ++Q +LE ++ +++ L +
Sbjct: 720 RTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQL 779
Query: 119 ATLEKQLIELTRTNELLKSKFSE-----NGNQKNLRILSLELMKLRNKRETKMRGMMAKQ 173
LEKQL E N+ LKS+ + + K L + LE + +E + + +
Sbjct: 780 NVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERH 839
Query: 174 EGMEMKL---QVTQRSLEESQG---------------KIAQLEGKLVSIEKEKIDEKSET 215
++++L ++ L ES+ +I QL L + +KE KS+
Sbjct: 840 MHVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDL 899
Query: 216 EKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLN 275
L+E +E +++ KL + Q EE+ + + EIL + +++ + + + E
Sbjct: 900 NNLMELLE-----AEKERNNKLSL-QFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQM 953
Query: 276 VKCQLLEK-----EKE-DHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDS 329
K Q LE+ EK + ++R+ ++ + A++ N Q+ R + +K ID+
Sbjct: 954 AKVQKLEESLLATEKVISSLEKSRDSDKKVVADLMNQIQEL------RTSVCEKTETIDT 1007
Query: 330 LLQQEKELSSSLHQKLCSFQEEMVK------------------------EKNLFEEELKQ 365
L Q+ K+++ + L +E V E+++ E+L
Sbjct: 1008 LKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAH 1067
Query: 366 TLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLL 425
++L+ L + ++ L++ +EE + ++ L+ KL K+ E+E+ +
Sbjct: 1068 ATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQ 1127
Query: 426 LQEKYDSMVQSLED--VTAQFESYKA----LTASEIEDLKLENSSLQEKAAKAGKNAEDV 479
L+ DS + + F+++ A EIED + +SL+ K ++ E
Sbjct: 1128 LEHVMDSAAEDPQSPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVK 1187
Query: 480 QHQILATESSNQEYVRMLLDLQT---KSALKETEIKEITVSFLQKITDLQN-----QLKQ 531
+IL + +E + L+ Q K+ L + ++ +I QK QN QLK
Sbjct: 1188 NAEILRMKEQLREMENLRLESQQLIEKNWLLQGQLDDIK---RQKENSDQNHPDNQQLKN 1244
Query: 532 QEEDFRKQ-----------------LEDEEGRKAEKENTTAELTEEINKWRLLYEELYNK 574
++E+ K+ LE+ + KE +T+E+ + + L + + +
Sbjct: 1245 EQEESIKERLAKSKIVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQE 1304
Query: 575 TKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENS 634
+ + +L+ E++ E ++Q+ + + KL+GHQNL QKI++VV+LK EN
Sbjct: 1305 KEQLRSKLEEMYEERERTSQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENV 1364
Query: 635 QLKSEVSKLRCQ---LAKKKQSET 655
+L E KLR + L +KK+SE+
Sbjct: 1365 RLAEETEKLRAENVFLKEKKRSES 1388
Score = 75.1 bits (183), Expect = 2e-13
Identities = 155/738 (21%), Positives = 316/738 (42%), Gaps = 126/738 (17%)
Query: 38 FQKSQRFKQQKESK----QNLNVDKDTTLPASARKVKSSESKI----RVLLQERGA---- 85
F+KS++ K+ K ++L + K+ + ++ VK E +I ++ + RG
Sbjct: 425 FKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLHKESRGGFLPE 484
Query: 86 -QDRRIQDLETELEKMEARL------------NAALREKT-------------SLSANN- 118
QDR + +L E++ + ++ N +LRE+ + A
Sbjct: 485 EQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMDAQTI 544
Query: 119 ATLEKQLIELTRTNELLKSK--FSENGNQKNLRILSLELMKLRNKR-ETKMRGMMAKQEG 175
A LEK E++ + K++ FS ++ + E +K + + +T++ +KQE
Sbjct: 545 AKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNN--SKQEY 602
Query: 176 MEMKLQVTQRSLE-ESQGKIAQ-----LEGKLVSIEKEKIDEKSETEKLLEYIEEISCAS 229
E K +R LE ES+ + Q LE L + + K E S+ K+ + E + +
Sbjct: 603 EEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEVSQLNKI--HAETLKIIT 660
Query: 230 DQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHV 289
+ Y+L + + + E+ S +N IL + + V ++ E+ E
Sbjct: 661 TPTKAYQLH----SRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAIS 716
Query: 290 NRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQ 349
R E ++A L+ K E+ + KLQQ +++ Q +EL SS Q
Sbjct: 717 EELRTVQEQMSA----LQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQ 772
Query: 350 EEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLK-GK 408
EE++ + N+ E++L++T + D L+ + ++ ++E S +KL K +
Sbjct: 773 EELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSS----VKLEYSSFKTNQ 828
Query: 409 EAELEKSSAAHTQATL-----------------LLQEKYDSMVQSLEDVTAQFESYKALT 451
E E K S H L LQ+ YD++ + ++ Q
Sbjct: 829 EKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNF 888
Query: 452 ASEIEDLKLENSSLQE--KAAKAGKNAEDVQHQILATESSNQEYVRML----LDLQTKSA 505
E E LK + ++L E +A K N +Q + E+S++E +++L + Q ++A
Sbjct: 889 KKENETLKSDLNNLMELLEAEKERNNKLSLQFE-EDKENSSKEILKVLEAVRQEKQKETA 947
Query: 506 LKETEIKEI------------TVSFLQK--------ITDLQNQLKQQEEDFRKQLEDEEG 545
E ++ ++ +S L+K + DL NQ+++ ++ E +
Sbjct: 948 KCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDT 1007
Query: 546 RKAEKENTTAELTEEI---NKWRLLYE----ELYNKTKPFQLQLDAFEVEKQALLNEHGA 598
K E ++ + + + R+L + ++ + + +L++ + ++E+ L +
Sbjct: 1008 LKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAH 1067
Query: 599 AQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQ 658
A EQLN + ++ K H L Q ++E ++ ++ + +L+ +L +KK+ + +
Sbjct: 1068 ATEQLNMLTEASKK---HSGLLQ------SAQEELTKKEALIQELQHKLNQKKEEVEQKK 1118
Query: 659 EELN-KVLGIKHFDPSKA 675
E N K+ ++H S A
Sbjct: 1119 NEYNFKMRQLEHVMDSAA 1136
Score = 39.7 bits (91), Expect = 0.010
Identities = 98/483 (20%), Positives = 191/483 (39%), Gaps = 110/483 (22%)
Query: 306 LKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQ 365
+K K ++ + + + Q + ++ L +Q EL+S ++ + K+
Sbjct: 363 IKNKAVVNEDTQGNVSQLQAEVKRLKEQLAELASG-----------QTPPESFLTRDKKK 411
Query: 366 TLDELDKLQQKEEQAERLVKQLEEEAKS------RAEELKLLEEK--------LKGKEAE 411
T + ++A K+ E+E KS + E+L L +EK +K +E +
Sbjct: 412 T-----NYMEYFQEAMLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQ 466
Query: 412 LEKSSAAHTQAT-LLLQEKYDSMVQSL----EDVTAQFESYKALTASEIEDLKLENSSLQ 466
+ + H ++ L E+ D ++ L + + Q E + + +E+ L + +
Sbjct: 467 IIRLEKLHKESRGGFLPEEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRR 526
Query: 467 EKAAKAGKNAEDVQHQILA------TESSNQEYVRMLLDLQTKSALKE----TEIKEITV 516
+ + K A+++ Q +A +E S E + A KE +++
Sbjct: 527 LRLLEPVKRAQEMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKA 586
Query: 517 SFLQKITDLQNQLKQQEEDF-----RKQLE-DEEGRKAEKEN---------TTAELTEEI 561
LQ T+L N KQ+ E+F ++QLE + E + +K N T A +E+
Sbjct: 587 QLLQIQTELNNS-KQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEV 645
Query: 562 NKWRLLYEE----LYNKTKPFQL----------QLDAF--------EVEKQALLNE---- 595
++ ++ E + TK +QL ++ +F + +LNE
Sbjct: 646 SQLNKIHAETLKIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPP 705
Query: 596 ------HGAAQEQLNKIRDSYAKLLG------HQNLKQKIKHVVKLKDENSQLKSEVSKL 643
A E+L +++ + L H+NLK + +HV KL+ ++Q++ S
Sbjct: 706 EMNEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQ-QHVDKLEHHSTQMQELFSSE 764
Query: 644 RCQLAKKKQS--------ETKLQE--ELNKVLGIKHFDPSKAFHHESKENFALKTPLKEG 693
R K+++ E +LQE N L + D H KE ++K
Sbjct: 765 RIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSF 824
Query: 694 NTN 696
TN
Sbjct: 825 KTN 827
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 127 bits (318), Expect = 5e-29
Identities = 146/703 (20%), Positives = 316/703 (44%), Gaps = 90/703 (12%)
Query: 32 LKGPVSFQKSQRFKQQKESKQN--LNVDKDTTLPASARKVKSSESKIRVLLQERGA---Q 86
LK ++ ++S R + + E +N L +KD + +++ ++ +L +++ A +
Sbjct: 219 LKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRI----DRLALLNEKQAASPLE 274
Query: 87 DRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQK 146
+ +++L + E + RL+ L++ L + +++++ +L+ N L K E +
Sbjct: 275 PKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFAS-- 332
Query: 147 NLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVT---QRSLEES----QGKIAQLEG 199
+L+ L L +L + + + KQ +E +L ++ LEE QGK++QLE
Sbjct: 333 HLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEE 392
Query: 200 KLVSIEKEKIDEKSETE----KLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 255
L ++ EK E +L +E + + + + + LE ++ ++L+
Sbjct: 393 HLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLA 452
Query: 256 LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFI---- 311
+ EE LS + DL L + KE+ ++ H L A++ +L +
Sbjct: 453 ERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNA 512
Query: 312 -----------LEQQEREK-------LQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMV 353
L+QQ +EK LQQ+E L Q ++LSSSL QK +E
Sbjct: 513 TIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAE 572
Query: 354 KEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELE 413
K++ ++ +Q ++ + + + +KQLE K +A +L++L+++L+ +
Sbjct: 573 KQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARD 632
Query: 414 KSSAAHTQA---TLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAA 470
+ + TQA L K + + +E TA+ E ++A +++ +L+L+ S Q+KA
Sbjct: 633 SAQTSVTQAQREKAELSRKVEELQACVE--TARQEQHEA--QAQVAELELQLRSEQQKAT 688
Query: 471 KAGKNAED---VQHQILA-------TESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQ 520
+ + A++ +Q Q+ A T+ S +E R D + +E+K T S ++
Sbjct: 689 EKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVE 748
Query: 521 KITDLQNQLKQQE---------------------EDFRKQLEDEEGRKAEKENTTAELTE 559
+ + +L+++ E R++L + + E+ +L +
Sbjct: 749 QHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVK 808
Query: 560 EINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNL 619
E+ WR YE+ + + F+ + L E A+++L + ++ A + H L
Sbjct: 809 EVAAWRERYEDSQQEEAQYGAM---FQEQLMTLKEECEKARQELQEAKEKVAGIESHSEL 865
Query: 620 KQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELN 662
+ + + ++E ++L + +++ Q+ +K+ KL ++L+
Sbjct: 866 Q-----ISRQQNELAELHANLARALQQVQEKEVRAQKLADDLS 903
Score = 99.8 bits (247), Expect = 8e-21
Identities = 154/679 (22%), Positives = 281/679 (41%), Gaps = 95/679 (13%)
Query: 81 QERGAQDRRIQDLETELEKMEA--RLNAALREKTSLSANNATLEKQLIELTRTNELLKSK 138
+ERG Q+R + L E + +A L A R + + NA L +Q +E E L
Sbjct: 997 EERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNA-LNEQRVEFATLQEALAHA 1055
Query: 139 FSENGNQKNLRILSLELMKLRNKRETKMRGMMA-KQEGMEMKLQVTQRSLEESQGKIAQL 197
+E + EL KLR +++ + +Q ++K Q+ ++ E + G AQ
Sbjct: 1056 LTEKEGKDQ------ELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQS 1109
Query: 198 EG---------KLVSIEKEKIDEKSETEKLLEYIEEI--SCASDQVEKYKLDIA--QLEE 244
E KL ++ E + + +K E + + S +++ + + D A L+
Sbjct: 1110 EAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQG 1169
Query: 245 NLKEKNDEI---LSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNA 301
L+EK E+ S S + + +V+D + E E + V R R+ E N+
Sbjct: 1170 QLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKA----EDEWKAQVARGRQEAERKNS 1225
Query: 302 EMQNLKQKF-ILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFE 360
+ +L+++ IL +Q EK + + ++ L+ E E S L ++L Q E
Sbjct: 1226 LISSLEEEVSILNRQVLEK-EGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAA 1284
Query: 361 EELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAE-------ELKLLEEKLKGKEAELE 413
E +E+ L+++ E+ + L +E S+AE ELK +EK KE L
Sbjct: 1285 ERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALS 1344
Query: 414 KSSAAHTQATLLLQEKYDS--MVQSLEDVTAQFE---------SYKALTASEIEDLKLEN 462
HT L+ E + + Q L+ A E S +A E L+ +
Sbjct: 1345 TLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQR 1404
Query: 463 S-----SLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSA------------ 505
L++K A+ + A+ Q+ A ++S E + ML A
Sbjct: 1405 ELGELIPLRQKVAEQERTAQ----QLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANL 1460
Query: 506 ---LKETEIKEITVSFLQKI----TDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELT 558
E E+ + ++Q++ D + +L + + + + + E A+ E ++
Sbjct: 1461 GRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVL 1520
Query: 559 EEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDS-YAKLLGHQ 617
EE R ++E K QL+ F+ E+ +E K+ DS A + Q
Sbjct: 1521 EE----RQRFQEERQKLTAQVEQLEVFQREQTK------QVEELSKKLADSDQASKVQQQ 1570
Query: 618 NLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQS--ETKLQEELNKVLGIKHFDPSKA 675
LK + + E +L++++++L+ QL++K+Q+ KLQ E K H+D K
Sbjct: 1571 KLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKT----HYDAKKQ 1626
Query: 676 FHHESKENFALKTPLKEGN 694
+ E +E L++ N
Sbjct: 1627 QNQELQEQLRSLEQLQKEN 1645
Score = 90.9 bits (224), Expect = 4e-18
Identities = 144/707 (20%), Positives = 292/707 (41%), Gaps = 109/707 (15%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETE-- 96
Q S KQ+++ + + ++ T A+++ ++ + L+ER A ++++ LE E
Sbjct: 555 QLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKA 614
Query: 97 --LEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFS---ENGNQKNLRIL 151
LE ++ +L A + S + +++ EL+R E L++ + ++ ++
Sbjct: 615 AKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVA 674
Query: 152 SLEL-MKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEK-- 208
LEL ++ ++ T+ + +++ ++ +LQ + SL+ ++G + + + + +E+
Sbjct: 675 ELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQR 734
Query: 209 -IDE-KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVI 266
I E K+ET L +E+ ++E+ + LE L++ + + + L +
Sbjct: 735 CISELKAETRSL---VEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAE 791
Query: 267 LSKQVEDLNVKCQLLEKEK-------EDHVNRNREHNENLNAEMQNLKQKFILEQQEREK 319
+C+ L KE ED ++ ++ LK++ +QE ++
Sbjct: 792 AMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQE 851
Query: 320 LQQK--------ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD 371
++K ELQI + EL ++L + L QE+ V+ + L D+L
Sbjct: 852 AKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKL--------ADDLS 903
Query: 372 KLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA-----------ELEKSSAAHT 420
LQ+K + V +LE + E+ + +L + A E + T
Sbjct: 904 TLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCST 963
Query: 421 QATL-LLQEKYDSMVQSLEDVTA-------QFESYKALTASEIEDLKLENSSLQ-----E 467
QA L ++ + + M LE + A Q + + E+ L E Q E
Sbjct: 964 QAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALE 1023
Query: 468 KAAKAG-----KNA------------EDVQHQILATESSNQEYVRMLLDLQTKSALKETE 510
KAA+A +NA E + H + E +QE ++ L+ +
Sbjct: 1024 KAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKL-------RGLEAAQ 1076
Query: 511 IKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEE 570
IKE L+++ QLK+Q K+ G ++E T ++ R +
Sbjct: 1077 IKE-----LEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSK 1131
Query: 571 LYNKTKPFQLQLDAFE---VEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN--------- 618
L + + Q Q D+ E ++A E +A E L + A+ LGH
Sbjct: 1132 LEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRE 1191
Query: 619 ---LKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELN 662
+ K++ K +DE K++V++ R + +K + L+EE++
Sbjct: 1192 LAAFRTKVQDHSKAEDE---WKAQVARGRQEAERKNSLISSLEEEVS 1235
Score = 88.2 bits (217), Expect = 2e-17
Identities = 136/625 (21%), Positives = 257/625 (41%), Gaps = 67/625 (10%)
Query: 45 KQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQ-DRRIQDLETELEKMEAR 103
K Q + K N +++ L R+ S +++ L E + + Q+ + ++E
Sbjct: 306 KSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKE 365
Query: 104 LNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLR---- 159
L+AAL++K L N L+ +L +L L+ + + +L LE +K
Sbjct: 366 LSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATL 425
Query: 160 --NKRETKMRGMMAKQEG--MEMKLQVTQRSLEESQGKIAQLEGKL------VSIEKEKI 209
N + + R M + E E KL + EE + +++ L L +S KE++
Sbjct: 426 AANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEEL 485
Query: 210 DEKSE------TEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEEN 263
++ S+ T ++ E++ + +++ ++A L++ KEK ++ Q E+
Sbjct: 486 EQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQA 545
Query: 264 IVILSKQVEDLNVKCQLLEKE-----------KEDHVNRNREHNENLNAEMQN----LKQ 308
L QVE L+ + E++ ++DH + E A ++ LKQ
Sbjct: 546 SQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQ 605
Query: 309 KFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLD 368
LE+++ KL+ + Q LQ E S + Q E + EE Q
Sbjct: 606 LEALEKEKAAKLEILQQQ----LQVANEARDSAQTSVTQAQREKAELSRKVEE--LQACV 659
Query: 369 ELDKLQQKEEQAE--RLVKQLEEEAKSRAEELKLLEEKLKGKEA-ELEKSSAAHTQATLL 425
E + +Q E QA+ L QL E + E+ ++ +EK + +E + K S T+ +L
Sbjct: 660 ETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSL- 718
Query: 426 LQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILA 485
+E+ +LE+ KA T S +E K E L+E+ +AG+ + + Q L
Sbjct: 719 -EEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEE--RAGRKGLEARLQQLG 775
Query: 486 ------TESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD-----------LQNQ 528
TE +E + T + E +KE+ ++ ++ D Q Q
Sbjct: 776 EAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVA-AWRERYEDSQQEEAQYGAMFQEQ 834
Query: 529 LKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVE 588
L +E+ K ++ + K + + +I++ + EL+ Q+ EV
Sbjct: 835 LMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVR 894
Query: 589 KQALLNEHGAAQEQLNKIRDSYAKL 613
Q L ++ QE++ A+L
Sbjct: 895 AQKLADDLSTLQEKMAATSKEVARL 919
Score = 63.9 bits (154), Expect = 5e-10
Identities = 78/394 (19%), Positives = 174/394 (44%), Gaps = 38/394 (9%)
Query: 42 QRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLE------- 94
++F Q++++ L ++ +T + + + ++ ++ A+ R ++LE
Sbjct: 1334 EKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAG 1393
Query: 95 ---TEL--------EKMEARLNAALREKTS--LSANNATLEKQLIELTRTNELLKSKFSE 141
EL E + R A +E+T+ L A A+ +QL L + + LL +
Sbjct: 1394 GLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRG 1453
Query: 142 NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKL 201
G + NL LE+ +L RE ++ + A + E +L QR E+Q +LE
Sbjct: 1454 LGERANLGRQFLEV-ELDQAREKYVQELAAVRADAETRLAEVQR---EAQSTARELEVMT 1509
Query: 202 VSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLE 261
E K+ E ++ E ++++ +Q+E ++ + + E L +K + + +
Sbjct: 1510 AKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQ 1569
Query: 262 ENIVILSKQVEDLNVKCQLLE---KEKEDHVNRNREHNENLNAEMQNLKQKFILEQQERE 318
+ + + Q + + Q L+ E + +++ + E+ +M+ K + ++Q+ +
Sbjct: 1570 QKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQ 1629
Query: 319 KLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD-KLQQKE 377
+LQ++ ++ L ++ KEL + + Q+ +K K E +QT L +++ E
Sbjct: 1630 ELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTK-----EAEQTCRHLTAQVRSLE 1684
Query: 378 EQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAE 411
Q +QL + K ++ + LK +E +
Sbjct: 1685 AQVAHADQQLRDLGK-----FQVATDALKSREPQ 1713
Score = 57.4 bits (137), Expect = 5e-08
Identities = 94/433 (21%), Positives = 183/433 (42%), Gaps = 82/433 (18%)
Query: 39 QKSQRFKQ-----QKESKQNLN--VDKDTTLPASARKVKSSESKIRV----LLQERGAQD 87
+KSQ+ ++ Q E+ N ++ + L + ++ K RV L QE +Q
Sbjct: 1260 EKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQA 1319
Query: 88 RRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKN 147
R ++L EL+ + + + ++L + + + + EL L + +E +
Sbjct: 1320 ERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEK 1379
Query: 148 LRILSLELMK----------LRNKRET----KMRGMMAKQEGMEMKLQVTQRSLEESQGK 193
LE K LR +RE +R +A+QE +L+ + S E
Sbjct: 1380 RHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSM 1439
Query: 194 IAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQV-EKYKLDIAQLEENLKEKNDE 252
+ + G L++ E + E++ + +E DQ EKY ++A + + + + E
Sbjct: 1440 LKKAHG-LLAEENRGLGERANLGRQFLEVE-----LDQAREKYVQELAAVRADAETRLAE 1493
Query: 253 ILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLK----- 307
+ QS + +++ + E VK +LE+ + R +E + L A+++ L+
Sbjct: 1494 VQREAQSTARELEVMTAKYEGAKVK--VLEERQ-----RFQEERQKLTAQVEQLEVFQRE 1546
Query: 308 --------QKFILEQQEREKLQQKEL------------QIDSLLQQEKELSSSLHQKLCS 347
K + + + K+QQ++L + L Q EL + L QK +
Sbjct: 1547 QTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQA 1606
Query: 348 ---FQEEMVKEKNLFE------EELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEEL 398
++ +M K K ++ +EL++ L L++LQ++ K+L EA+ EL
Sbjct: 1607 AEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKEN-------KELRAEAERLGHEL 1659
Query: 399 KLLEEKLKGKEAE 411
+ + LK KEAE
Sbjct: 1660 Q--QAGLKTKEAE 1670
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 123 bits (308), Expect = 7e-28
Identities = 121/546 (22%), Positives = 249/546 (45%), Gaps = 50/546 (9%)
Query: 156 MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 213
MKL K + ++ ++E MK + T+ L +++ K +LE K+V++ +EK D +
Sbjct: 834 MKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQL 893
Query: 214 ETEKLLEYIEEISCASDQVEKYKL-------DIAQLEENLKEKNDEILSLKQSLEENIVI 266
+ + + + + DQ+ K K+ ++ + E+ +E N E+ + K+ LE+
Sbjct: 894 QVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 953
Query: 267 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQ 326
L K ++DL + +EKEK H N+ +NL EM L + +E++ LQ+ Q
Sbjct: 954 LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1009
Query: 327 IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 386
LQ E++ ++L + ++++ + E+E K +D L++ + + E +K
Sbjct: 1010 TLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMD----LERAKRKLEGDLKL 1065
Query: 387 LEEEAKSRAEELKLLEEKLKGKEAELE--KSSAAHTQA-TLLLQEKYDSMVQSLEDVTAQ 443
+E + + L EKLK KE E+ + QA + LQ+K + +E++ +
Sbjct: 1066 AQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEE 1125
Query: 444 FESYKALTA---SEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDL 500
E+ +A A + DL E + E+ +AG QI + E+ +M DL
Sbjct: 1126 IEAERASRAKAEKQRSDLSRELEEISERLEEAG---GATSAQIEMNKKREAEFQKMRRDL 1182
Query: 501 QTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEE 560
+ + E + + +L Q+ + +++LE E+ + N A E
Sbjct: 1183 EESTLQHEATAAALRKKHADSVAELGEQIDSLQR-VKQKLEKEKSELKMEINDLASNMET 1241
Query: 561 INKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLL------ 614
++K + +E++ + ++ E E+Q L+NE A + +L+ +++ L
Sbjct: 1242 VSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAM 1301
Query: 615 ------GHQNLKQKIKHVVKLKDENSQLKSEVSK-----------LRCQLAKKKQSETKL 657
G Q Q+I+ + + +E ++ KS ++ LR Q ++++++ +L
Sbjct: 1302 VSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAEL 1361
Query: 658 QEELNK 663
Q ++K
Sbjct: 1362 QRGMSK 1367
Score = 114 bits (285), Expect = 3e-25
Identities = 143/678 (21%), Positives = 300/678 (44%), Gaps = 82/678 (12%)
Query: 40 KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEK 99
K + ++ E ++ +N + L A RK++ S+++ + I DLE L K
Sbjct: 922 KIKEVTERAEDEEEINAE----LTAKKRKLEDECSELK----------KDIDDLELTLAK 967
Query: 100 MEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLR 159
+E +A + +L+ A L++ + +LT+ + L + +Q+ L L +E K+
Sbjct: 968 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKAL-----QEAHQQTLDDLQMEEDKVN 1022
Query: 160 --NKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEK 217
K +TK+ + EG + + LE ++ K LEG L ++ +D +++ ++
Sbjct: 1023 TLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRK---LEGDLKLAQESTMDTENDKQQ 1079
Query: 218 LLEYIE----EISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVED 273
L E ++ E+S ++E + QL++ +KE I L++ +E +K +
Sbjct: 1080 LNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQ 1139
Query: 274 LNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQID----S 329
+ L +E E+ R E +A+++ K++ Q+ R L++ LQ + +
Sbjct: 1140 RSD----LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAA 1195
Query: 330 LLQQEKELSSSLHQKLCSFQ---EEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 386
L ++ + + L +++ S Q +++ KEK+ + E+ ++ + + + E++ +
Sbjct: 1196 LRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRT 1255
Query: 387 LEE---EAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQ 443
LE+ E K++ EE + L +L ++A L S ++ L EK D+MV L
Sbjct: 1256 LEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQ---LDEK-DAMVSQLSRGKQA 1311
Query: 444 FESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTK 503
F ++E+ S+L A + + ++ Q + + E R + ++
Sbjct: 1312 FTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSE 1371
Query: 504 SALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK 563
A T+ + + +++ + + +L Q+ +D + +E + A E T L E+
Sbjct: 1372 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVED 1431
Query: 564 WRLLYEE-------LYNKTKPFQLQL-------DAFEVEKQALLNEHGAAQEQLNKIRDS 609
+ E L K + F L + + E +A E + +L K++++
Sbjct: 1432 LMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNA 1491
Query: 610 YAKLLGH--------QNLKQKI-----------KHVVKLKDENSQLKSEVSKLRCQLAKK 650
Y + L H +NL+Q+I KH+ +L+ QL E S+L+ L
Sbjct: 1492 YEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSL--- 1548
Query: 651 KQSETKLQEELNKVLGIK 668
+++E L+ E K+L I+
Sbjct: 1549 EEAEASLEHEEGKILRIQ 1566
Score = 102 bits (253), Expect = 2e-21
Identities = 136/661 (20%), Positives = 293/661 (44%), Gaps = 68/661 (10%)
Query: 52 QNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALREK 111
Q +D + K+K E ++ L + + L+ ++++++AR+ E
Sbjct: 1067 QESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEI 1126
Query: 112 TSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMA 171
+ A+ A EKQ +L+R E + + E G + +I ++ KRE + + M
Sbjct: 1127 EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI------EMNKKREAEFQKMRR 1180
Query: 172 KQEGMEMKLQVTQRSLEESQG-KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASD 230
E ++ + T +L + +A+L ++ S+++ K + E +L I +++ +
Sbjct: 1181 DLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNME 1240
Query: 231 QVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK---EKED 287
V K K + ++ L+++ EI + ++ + I LS Q L+ + + EK+
Sbjct: 1241 TVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDA 1300
Query: 288 HVNRNREHNENLNAEMQNLKQKFILEQQEREK------LQQKELQIDSLLQQ---EKELS 338
V++ + +++ LK++ LE++ + K LQ D L +Q E+E
Sbjct: 1301 MVSQLSRGKQAFTQQIEELKRQ--LEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAK 1358
Query: 339 SSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD----KLQQKEEQAERLVKQLEEEAKSR 394
+ L + + E+ + + +E + Q +EL+ KL Q+ + AE V+ + + S
Sbjct: 1359 AELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASL 1418
Query: 395 AEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASE 454
+ + L+ +++ ++E+S+A A + L +K ++ + V A+++ T +E
Sbjct: 1419 EKTKQRLQNEVEDLMIDVERSNA----ACIALDKKQ----RNFDKVLAEWKQKYEETQAE 1470
Query: 455 IEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEI 514
+E + E+ SL + K E+ + + N+ + + DL + A I E+
Sbjct: 1471 LEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHEL 1530
Query: 515 TVSFLQKITDLQNQLKQQEEDFRKQLEDEEGR-----------KAEKENTTAELTEEINK 563
+++ +++L+ E+ LE EEG+ K+E + AE EE+++
Sbjct: 1531 E-KVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQ 1589
Query: 564 WR---LLYEELYNKTKPFQLQL--DAFEVEK--QALLNE--------HGAAQEQLNKIRD 608
+ L E T +++ DA ++K + LNE + A E L +R+
Sbjct: 1590 LKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRN 1649
Query: 609 SYAKLLGHQ-NLKQKIKHVVKLKDENSQ-------LKSEVSKLRCQLAKKKQSETKLQEE 660
+ L Q +L I+ LK++ + +++EV +LR L + ++ ++E
Sbjct: 1650 TQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQE 1709
Query: 661 L 661
L
Sbjct: 1710 L 1710
Score = 87.4 bits (215), Expect = 4e-17
Identities = 139/642 (21%), Positives = 275/642 (42%), Gaps = 111/642 (17%)
Query: 42 QRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKME 101
QR ++ +E+K+ L A++++ +E + + + + ++ Q L+ E+E +
Sbjct: 1385 QRTEELEEAKKKL-----------AQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLM 1433
Query: 102 ARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNK 161
+ + +L +K L E + E +++ +QK R LS EL K++N
Sbjct: 1434 IDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELE--ASQKESRSLSTELFKVKNA 1491
Query: 162 RETKMRGMMA-KQEGMEMKLQVTQRSLEESQG--KIAQLEGKLVSIEKEKIDEKSETEKL 218
E + + K+E ++ +++ + + ++G I +LE ++K+ EKSE +
Sbjct: 1492 YEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELE----KVKKQLDHEKSELQTS 1547
Query: 219 LEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKC 278
LE E AS + E+ K+ QLE N +K ++ I ++++ L
Sbjct: 1548 LEEAE----ASLEHEEGKILRIQLELN---------QVKSEIDRKIAEKDEELDQL---- 1590
Query: 279 QLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELS 338
K +H+ L+AE+++ ++++ L + E+Q++ +Q E
Sbjct: 1591 ------KRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEAL 1644
Query: 339 SSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEEL 398
+L + ++K+ L L + D L+++ ER ++ E + L
Sbjct: 1645 RNLRNT-----QGILKDTQL---HLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASL 1696
Query: 399 KLLEEKLKGKEAEL----EKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASE 454
+ E K E EL E+ HTQ T L+ K + LE +Q + E
Sbjct: 1697 ERTERGRKMAEQELLDASERVQLLHTQNTSLINTK-----KKLETDISQIQG-------E 1744
Query: 455 IEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRM-------------LLDLQ 501
+ED+ E + +EKA KA +A + ++ + ++ RM LD
Sbjct: 1745 MEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEA 1804
Query: 502 TKSALK--ETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTE 559
+ ALK + +I+++ + ++++++ K E K L E R E T E +
Sbjct: 1805 EQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAV-KGLRKHERRVKELTYQTEEDRK 1863
Query: 560 EINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNL 619
I + + L ++L K K ++ Q A E E+Q+ +N L K R
Sbjct: 1864 NILRLQDLVDKLQTKVKAYKRQ--AEEAEEQSNVN--------LAKFR------------ 1901
Query: 620 KQKIKHVVKLKDENSQL-KSEVSKLRCQLAKKKQSETKLQEE 660
K++H ++ E + + +S+V+KLR K ++ TK+ E
Sbjct: 1902 --KLQHELEEAKERADIAESQVNKLR---VKSREVHTKVISE 1938
Score = 66.6 bits (161), Expect = 7e-11
Identities = 88/430 (20%), Positives = 195/430 (45%), Gaps = 54/430 (12%)
Query: 28 TLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKI-RVLL---QER 83
T ++ +G + ++ K+Q + +++ + T+L + ++ E KI R+ L Q +
Sbjct: 1517 TEQIAEGGKHIHELEKVKKQLDHEKS---ELQTSLEEAEASLEHEEGKILRIQLELNQVK 1573
Query: 84 GAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENG 143
DR+I + + EL++++ LR S+ + TL+ E+ N+ L+ K G
Sbjct: 1574 SEIDRKIAEKDEELDQLKRN---HLRVVESMQS---TLDA---EIRSRNDALRIKKKMEG 1624
Query: 144 NQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVS 203
+ + I + N++ + + +G+ L+ TQ L+++ L+ +L
Sbjct: 1625 DLNEMEIQ----LNHANRQAAEALRNLRNTQGI---LKDTQLHLDDAIRGQDDLKEQLAM 1677
Query: 204 IEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEEN 263
+E+ ++E E+L +E E+ LD ++ + L +N +++ K+ LE +
Sbjct: 1678 VERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETD 1737
Query: 264 IVILSKQVEDLNVKCQLLEKEKE----------DHVNRNREHNENLNAEMQNLKQ----- 308
I + ++ED+ + + E++ + + + + ++ + +L +N++Q
Sbjct: 1738 ISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDL 1797
Query: 309 KFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQ---------KLCSFQEEMVKEKNLF 359
+ L++ E+ L+ + QI L + +EL S + K E VKE
Sbjct: 1798 QLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQ 1857
Query: 360 EEELKQTL----DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKS 415
EE ++ + D +DKLQ K + +R ++ EE++ + + L+ +L E E++
Sbjct: 1858 TEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHEL---EEAKERA 1914
Query: 416 SAAHTQATLL 425
A +Q L
Sbjct: 1915 DIAESQVNKL 1924
Score = 61.2 bits (147), Expect = 3e-09
Identities = 78/362 (21%), Positives = 159/362 (43%), Gaps = 42/362 (11%)
Query: 67 RKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEK--- 123
R V+S +S + ++ R R + +E +L +ME +LN A R+ N +
Sbjct: 1596 RVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILK 1655
Query: 124 ----QLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGM-MAKQEGMEM 178
L + R + LK + + + NL + E+ +LR E RG MA+QE ++
Sbjct: 1656 DTQLHLDDAIRGQDDLKEQLAMVERRANL--MQAEVEELRASLERTERGRKMAEQELLDA 1713
Query: 179 KLQV------------TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEIS 226
+V T++ LE I+Q++G++ I +E ++ EK + I + +
Sbjct: 1714 SERVQLLHTQNTSLINTKKKLETD---ISQIQGEMEDIVQEA---RNAEEKAKKAITDAA 1767
Query: 227 CASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE 286
+++++K + A LE K + L+ L+E + K + K + +E E
Sbjct: 1768 MMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELE 1827
Query: 287 DHVNRNREHN----ENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLH 342
V ++HN + L + +K+ +++R+ + + + +D L + K
Sbjct: 1828 SEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQ-- 1885
Query: 343 QKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLE 402
EE ++ N+ + ++ EL++ +++ + AE V +L KSR K++
Sbjct: 1886 ------AEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKL--RVKSREVHTKVIS 1937
Query: 403 EK 404
E+
Sbjct: 1938 EE 1939
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 122 bits (305), Expect = 1e-27
Identities = 175/745 (23%), Positives = 313/745 (42%), Gaps = 123/745 (16%)
Query: 25 DVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKI---RVLLQ 81
D ++ + + QK ++ + K L DTT + K + + L +
Sbjct: 1126 DFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEE 1185
Query: 82 ERGAQDRRIQDLE----TELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKS 137
E + +IQD+ T LE++ +L A R K +L N LE EL ++L+
Sbjct: 1186 ETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQ 1245
Query: 138 KFSENGNQKN------------------LRI-LSLELMKLRNK--------RETKMRGMM 170
+E+ +++ LR+ L+ + KL+N+ E + +G+
Sbjct: 1246 VKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIK 1305
Query: 171 AKQEG--MEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCA 228
++ +E +LQ TQ L+E + L ++ +E+EK L E EE A
Sbjct: 1306 FAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEK-------NSLQEQQEEEEEA 1358
Query: 229 SDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDH 288
+EK L + + K+K D+ L +SLEE L K E L+ + + EK
Sbjct: 1359 RKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLE----EKALA 1414
Query: 289 VNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK---- 344
++ + L E+ +L ++Q L++K+ + D LL +EK +S+ ++
Sbjct: 1415 YDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRA 1474
Query: 345 -------------LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEA 391
L EE ++ K FE + KQ +++ L ++ + V +LE+
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSK 1534
Query: 392 KSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALT 451
++ ++++ + +L+ E EL+ + A + + +Q + L+ Q E K L
Sbjct: 1535 RALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLL 1594
Query: 452 ASEIEDL--KLENSSLQEKAAKAGK-----NAEDVQHQILATESSNQEYVRMLLDLQTKS 504
++ +L +LE+ Q A A K + +D++ QI A + E ++ L LQ +
Sbjct: 1595 IKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQM 1654
Query: 505 ALKETEIKEITVS----FLQ-------------KITDLQNQLKQQE------EDFRKQLE 541
+ E++E S F Q +I LQ +L E E R +L
Sbjct: 1655 KDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELA 1714
Query: 542 DE-----EGRKA---EK---ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQ 590
DE G+ A EK E A+L EE+ + + E L ++ + LQ+D E
Sbjct: 1715 DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAE-- 1772
Query: 591 ALLNEHGAAQEQLNKIRDSYAKLLGHQN--LKQKIKHV-----VKLKDENSQLKSEVSKL 643
L E AAQ+ D+ + L QN LK K++ + K K S L++++ +L
Sbjct: 1773 -LAAERSAAQKS-----DNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQL 1826
Query: 644 RCQL---AKKKQSETKLQEELNKVL 665
QL AK++ + KL K L
Sbjct: 1827 EEQLEQEAKERAAANKLVRRTEKKL 1851
Score = 106 bits (264), Expect = 8e-23
Identities = 134/637 (21%), Positives = 289/637 (45%), Gaps = 52/637 (8%)
Query: 40 KSQRFKQQKESKQNLNVDK---DTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETE 96
+++ F + +E + L K + L +V+ E + ++L E+ IQDLE +
Sbjct: 899 ETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQ 958
Query: 97 LEKMEARLNAALREKTSLSANNATLEKQLIELTRTN-------ELLKSKFSENGNQ-KNL 148
L++ E EK + A +E++++ L N +L++ + +E +Q
Sbjct: 959 LDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE 1018
Query: 149 RILSLELMKLRNKRETKMRGM---MAKQEGMEMKLQVTQRSLE----ESQGKIAQLEGKL 201
+ L K+RNK+E + + + K+E +L+ +R L+ + Q +IA+L+ ++
Sbjct: 1019 EEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQI 1078
Query: 202 VSIEKEKIDEKSETEKLLEYIEEISC----ASDQVEKYKLDIAQLEENL---KEKNDEIL 254
++ + ++ E + L ++ + A V + + IA+L+E+ K ++
Sbjct: 1079 DELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAE 1138
Query: 255 SLKQSLEENIVILSKQVE---DLNVKCQLLEKEKEDHVNRNR----EHNENLNAEMQNLK 307
K+ L E + L ++E D Q L ++E V + E +N A++Q+++
Sbjct: 1139 KQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMR 1198
Query: 308 QKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL 367
Q+ +E + ++ + + L++ K+ + +++L + + + K E + K+
Sbjct: 1199 QRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLD 1258
Query: 368 DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQ 427
++ +L K + +RL +L E+A EL + L +EAE + A A+L
Sbjct: 1259 AQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLL--EEAEKKGIKFAKDAASL--- 1313
Query: 428 EKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 487
+S +Q +++ + K +S I L+ E +SLQE+ + + ++++ Q+LA +
Sbjct: 1314 ---ESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQ 1370
Query: 488 SSNQEYVRML-LDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGR 546
S + + + DL T +L+E + +K+ L Q+ E+ + E
Sbjct: 1371 SQLADTKKKVDDDLGTIESLEEAK---------KKLLKDAEALSQRLEEKALAYDKLEKT 1421
Query: 547 KAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKI 606
K + +LT +++ R + L K K F QL A E A E E +
Sbjct: 1422 KNRLQQELDDLTVDLDHQRQVASNLEKKQKKFD-QLLAEEKSISARYAEERDRAEAEARE 1480
Query: 607 RDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKL 643
+++ A L + L++ ++ + + +N QL++++ L
Sbjct: 1481 KETKALSLA-RALEEALEAKEEFERQNKQLRADMEDL 1516
Score = 101 bits (252), Expect = 2e-21
Identities = 153/693 (22%), Positives = 308/693 (44%), Gaps = 106/693 (15%)
Query: 42 QRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKME 101
+R K++++++Q L K RK+ + ++ + E AQ I +L+ +L K E
Sbjct: 1041 ERLKKEEKTRQELEKAK--------RKLDGETTDLQDQIAELQAQ---IDELKLQLAKKE 1089
Query: 102 ARLNAALR--EKTSLSANNAT-----LEKQLIELTRTNELLKSKFSENGNQKNLRILSLE 154
L AL + +L NNA L+ Q+ EL E K S N +K R LS E
Sbjct: 1090 EELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFE--SEKASRNKAEKQKRDLSEE 1147
Query: 155 LMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSE 214
L L+ + E + A+QE T+R E ++ K A +E+E + +++
Sbjct: 1148 LEALKTELEDTLDTTAAQQELR------TKREQEVAELKKA--------LEEETKNHEAQ 1193
Query: 215 TEKLLEY----IEEISCASDQVEKYKLDIAQLEENLKEKNDEIL-------SLKQSLEEN 263
+ + + +EE+S +Q +++K ++ + ++ L+ N E+ +K E
Sbjct: 1194 IQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHK 1253
Query: 264 IVILSKQVEDLNVKCQ---LLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKL 320
L QV++L+ K L E + ++ + +N++ ++ ++K I ++ L
Sbjct: 1254 RKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASL 1313
Query: 321 QQKELQIDSLLQQEKELSSSLHQKLCSFQEEM--VKEKNLFEEELKQTLD--------EL 370
+ + LLQ+E +L ++ +EE ++E+ EEE ++ L+ +L
Sbjct: 1314 ESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQL 1373
Query: 371 DKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKY 430
++K + ++ LEE K ++ + L ++L+ K +K + LQ++
Sbjct: 1374 ADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNR----LQQEL 1429
Query: 431 DSMV----------QSLEDVTAQFESY----KALTASEIEDLKLENSSLQEKAAKAGKNA 476
D + +LE +F+ K+++A E+ + +EK KA A
Sbjct: 1430 DDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLA 1489
Query: 477 EDVQHQILATESSNQEYVRMLLDLQTKSALKET------EIKEITVSFLQKITDLQNQLK 530
++ + A E ++ ++ D++ + K+ E+++ + Q++ +++ QL+
Sbjct: 1490 RALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLE 1549
Query: 531 QQE------EDFRKQLE-DEEGRKAEKEN---TTAELTEE-----INKWRLLYEELYNKT 575
+ E ED + +LE + + KA+ E T E EE I + R L EL ++
Sbjct: 1550 ELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDER 1609
Query: 576 KPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQ 635
K L + A + + + L + A E NK RD K L + L+ ++K + +E
Sbjct: 1610 KQRALAV-ASKKKMEIDLKDLEAQIEAANKARDEVIKQL--RKLQAQMKDYQRELEEARA 1666
Query: 636 LKSEVSKLRCQLAKKKQSETKLQEELNKVLGIK 668
+ E+ A+ K+SE KL+ ++L ++
Sbjct: 1667 SRDEI------FAQSKESEKKLKSLEAEILQLQ 1693
Score = 101 bits (251), Expect = 3e-21
Identities = 168/730 (23%), Positives = 315/730 (43%), Gaps = 113/730 (15%)
Query: 67 RKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSAN--------- 117
R+ + ++K LL+ + Q + +E ELE+ME + L EK L+
Sbjct: 849 RQEEELQAKDEELLKVKEKQTK----VEGELEEMERKHQQLLEEKNILAEQLQAETELFA 904
Query: 118 -----NATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAK 172
A L + EL L+S+ E ++ +IL E K++ + + + +
Sbjct: 905 EAEEMRARLAAKKQELEEILHDLESRVEE--EEERNQILQNEKKKMQAHIQ-DLEEQLDE 961
Query: 173 QEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQV 232
+EG KLQ+ + + E KI ++E +++ +E + + K EK L C+S
Sbjct: 962 EEGARQKLQLEKVTAE---AKIKKMEEEILLLEDQ--NSKFIKEKKLMEDRIAECSSQLA 1016
Query: 233 E-------------KYKLDIAQLEENLKEK---NDEILSLKQSLEENIVILSKQVEDL-- 274
E K ++ I+ LEE LK++ E+ K+ L+ L Q+ +L
Sbjct: 1017 EEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQA 1076
Query: 275 ---NVKCQLLEKEKE------------DHVNRNREHNENLNAEMQNLKQKFILEQQEREK 319
+K QL +KE+E H N + L A++ L++ F E+ R K
Sbjct: 1077 QIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNK 1136
Query: 320 LQQKELQIDSLLQQEK-ELSSSL-----HQKLCSFQEEMVKE-KNLFEEELKQTLDELDK 372
++++ + L+ K EL +L Q+L + +E+ V E K EEE K ++
Sbjct: 1137 AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQD 1196
Query: 373 LQQKEEQA-ERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLL----- 426
++Q+ A E L +QLE+ + +A LE+ +G E + K A + +
Sbjct: 1197 MRQRHATALEELSEQLEQAKRFKAN----LEKNKQGLETD-NKELACEVKVLQQVKAESE 1251
Query: 427 --QEKYDSMVQSLEDVTAQFESYKALTASEIEDL--KLEN-SSLQEKAAKAG----KNAE 477
++K D+ VQ L ++ + + A + L +L+N S+L E+A K G K+A
Sbjct: 1252 HKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAA 1311
Query: 478 DVQHQILATESSNQEYVRMLLDL--------QTKSALKE--TEIKEITVSFLQKITDLQN 527
++ Q+ T+ QE R L+L + K++L+E E +E + +++ LQ+
Sbjct: 1312 SLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQS 1371
Query: 528 QL---KQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA 584
QL K++ +D +E E K + L++ + + L Y++L Q +LD
Sbjct: 1372 QLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDD 1431
Query: 585 FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN------LKQKIKHVVKLKDENSQLKS 638
V+ L+ L K + + +LL + +++ + + +++ ++ S
Sbjct: 1432 LTVD----LDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALS 1487
Query: 639 EVSKLRCQLAKKKQSE---TKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNT 695
L L K++ E +L+ ++ ++ K D K H K AL+ ++E T
Sbjct: 1488 LARALEEALEAKEEFERQNKQLRADMEDLMSSKD-DVGKNVHELEKSKRALEQQVEEMRT 1546
Query: 696 NCYRAPMECQ 705
E Q
Sbjct: 1547 QLEELEDELQ 1556
Score = 73.6 bits (179), Expect = 6e-13
Identities = 100/410 (24%), Positives = 174/410 (42%), Gaps = 49/410 (11%)
Query: 267 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ---EREKLQQK 323
+++Q E+L K + L K KE E E Q L++K IL +Q E E +
Sbjct: 847 VTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEA 906
Query: 324 ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 383
E L +++EL LH E V+E EEE Q L K Q Q L
Sbjct: 907 EEMRARLAAKKQELEEILHDL-----ESRVEE----EEERNQILQNEKKKMQAHIQD--L 955
Query: 384 VKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQ 443
+QL+EE +R ++ +LEK +A +A + +K + + LED ++
Sbjct: 956 EEQLDEEEGAR-------------QKLQLEKVTA---EAKI---KKMEEEILLLEDQNSK 996
Query: 444 FESYKALTASEIEDLKLENSSLQEKAAKAGK--NAEDVQHQILATESSNQEYVRMLLDLQ 501
F K L I + + + +EKA K N ++V L +E R L+
Sbjct: 997 FIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKA 1056
Query: 502 TKSALKETEIKEITVSFLQ-KITDLQNQLKQQEEDFRKQLEDEEGRKAEKENT------- 553
+ ET + ++ LQ +I +L+ QL ++EE+ + L + K N
Sbjct: 1057 KRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVREL 1116
Query: 554 ---TAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSY 610
AEL E+ + + + + +L+A + E + L+ A QE K
Sbjct: 1117 QAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEV 1176
Query: 611 AKLLGHQNLKQKIK-HVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 659
A+L + L+++ K H +++D + + + +L QL + K+ + L++
Sbjct: 1177 AEL--KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEK 1224
Score = 72.8 bits (177), Expect = 1e-12
Identities = 100/441 (22%), Positives = 191/441 (43%), Gaps = 71/441 (16%)
Query: 30 EVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRR 89
E L+ F++ KQ + ++L KD + V E R L Q+ +
Sbjct: 1494 EALEAKEEFERQN--KQLRADMEDLMSSKDDV----GKNVHELEKSKRALEQQVEEMRTQ 1547
Query: 90 IQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNEL-----------LKSK 138
+++LE EL+ E +A LR + ++ A A E+ L NE L+++
Sbjct: 1548 LEELEDELQATE---DAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAE 1604
Query: 139 FSENGNQKNLRILSLELMKLRNK-------RETKMRGMMAKQ-EGMEMKLQVTQRSLEES 190
+ Q+ L + S + M++ K K R + KQ ++ +++ QR LEE+
Sbjct: 1605 LEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEA 1664
Query: 191 ---------------------QGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI---- 225
+ +I QL+ +L S E+ + + E ++L + I
Sbjct: 1665 RASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGK 1724
Query: 226 SCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVK--CQLLEK 283
S D+ + + IAQLEE L+E+ + L + + QV+ LN + +
Sbjct: 1725 SALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTL----QVDTLNAELAAERSAA 1780
Query: 284 EKEDHVNRNREH-NENLNAEMQNL----KQKFILEQQEREKLQQKELQIDSLLQQEKELS 338
+K D+ + E N+ L A++Q L K KF + L+ K Q++ L+QE +
Sbjct: 1781 QKSDNARQQLERQNKELKAKLQELEGAVKSKF---KATISALEAKIGQLEEQLEQEAKER 1837
Query: 339 SSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEEL 398
++ + KL E+ +KE + E+ ++ D+ +++ E+A +KQL+ + + EE
Sbjct: 1838 AAAN-KLVRRTEKKLKEIFMQVEDERR---HADQYKEQMEKANARMKQLKRQLEEAEEEA 1893
Query: 399 KLLEEKLKGKEAELEKSSAAH 419
+ + EL+ ++ A+
Sbjct: 1894 TRANASRRKLQRELDDATEAN 1914
Score = 70.9 bits (172), Expect = 4e-12
Identities = 82/400 (20%), Positives = 178/400 (44%), Gaps = 41/400 (10%)
Query: 317 REKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLF-----EEELKQTLDELD 371
R+ +K+ Q+ +L ++ ++ L + + K K L EEEL+ +EL
Sbjct: 803 RKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELL 862
Query: 372 KLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLK------GKEAELEKSSAAHTQATLL 425
K+++K+ + E ++++E + + EE +L E+L+ + E+ AA Q
Sbjct: 863 KVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEE 922
Query: 426 LQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLE-------NSSLQEKAAKAGKNAED 478
+ +S V+ E+ ++ K + I+DL+ + LQ + A +
Sbjct: 923 ILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKK 982
Query: 479 VQHQILATESSNQEYV--RMLLD---LQTKSALKETEIKEITVSFLQK-----ITDLQNQ 528
++ +IL E N +++ + L++ + S L E E K ++ ++ I+DL+ +
Sbjct: 983 MEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEER 1042
Query: 529 LKQQE---EDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF 585
LK++E ++ K +G + ++ AEL +I++ +L + + + + D
Sbjct: 1043 LKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDE 1102
Query: 586 EVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRC 645
+ K L Q Q+ ++++ + +N +K K L +E LK+E+
Sbjct: 1103 TLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKR--DLSEELEALKTELEDTLD 1160
Query: 646 QLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFA 685
A +++ TK ++E+ ++ KA E+K + A
Sbjct: 1161 TTAAQQELRTKREQEVAEL--------KKALEEETKNHEA 1192
Score = 67.4 bits (163), Expect = 4e-11
Identities = 80/389 (20%), Positives = 170/389 (43%), Gaps = 26/389 (6%)
Query: 43 RFKQQKESKQNLNVDKDTTLPASARKVKSS---ESKIRVL-LQERGAQDRRIQDLETELE 98
+F++ +++ N +K L R++++ E K R L + + + ++DLE ++E
Sbjct: 1575 QFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIE 1634
Query: 99 KMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKL 158
+ +++ L A +++L E + + + ++ E+ +K L+ L E+++L
Sbjct: 1635 AANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKES--EKKLKSLEAEILQL 1692
Query: 159 RNKRETKMRGMM-AKQEGMEMKLQVTQRSLEESQ--GKIAQLEGKLVSIEKEKIDEKSET 215
+ + + R A+QE E+ ++T + +S + +LE ++ +E+E +E+S
Sbjct: 1693 QEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNM 1752
Query: 216 EKLLEYIEEISCASDQVEKY---KLDIAQLEEN----LKEKNDEILSLKQSLEENIVILS 268
E L + + + D + + AQ +N L+ +N E+ + Q LE +
Sbjct: 1753 ELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKF 1812
Query: 269 KQ-VEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQI 327
K + L K LE++ E N+ + + LK+ F+ + ER Q + Q+
Sbjct: 1813 KATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQM 1872
Query: 328 DSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQL 387
+ + K+L L + EE N +L++ ELD + E R V L
Sbjct: 1873 EKANARMKQLKRQLEE-----AEEEATRANASRRKLQR---ELDDATEANEGLSREVSTL 1924
Query: 388 EEEAKSRAEELKLLEEKLKGKEAELEKSS 416
+ + R + + ++ LE +S
Sbjct: 1925 KNRLR-RGGPISFSSSRSGRRQLHLEGAS 1952
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 122 bits (305), Expect = 1e-27
Identities = 134/550 (24%), Positives = 258/550 (46%), Gaps = 58/550 (10%)
Query: 156 MKLRNKRETKMRGMMAKQEGMEMKLQV--TQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 213
MKL K + ++ ++E MK + + +LE+S+ + +LE K+VS+ +EK D +
Sbjct: 832 MKLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQL 891
Query: 214 ETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND----------EILSLKQSLEEN 263
+ + + + + DQ+ K K+ QLE +KE N+ E+ + K+ LE+
Sbjct: 892 QVQAEQDNLNDAEERCDQLIKNKI---QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE 948
Query: 264 IVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK 323
L K ++DL + +EKEK H N+ +NL EM L + +E++ LQ+
Sbjct: 949 CSELKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDEIIAKLTKEKKALQEA 1004
Query: 324 ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 383
Q LQ E++ +SL + ++++ + E+E K +D L++ + + E
Sbjct: 1005 HQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMD----LERAKRKLEGD 1060
Query: 384 VKQLEEEAKSRAEELKLLEEKLKGKEAEL-EKSSAAHTQATLLLQ-----EKYDSMVQSL 437
+K +E + LEEKLK KE ++ +++S + L LQ ++ + ++ L
Sbjct: 1061 LKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEEL 1120
Query: 438 EDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRML 497
E+ + +A DL E + E+ +AG A V QI + E+ +M
Sbjct: 1121 EEELEAERTARAKVEKLRSDLSRELEEISERLEEAG-GATSV--QIEMNKKREAEFQKMR 1177
Query: 498 LDLQ--------TKSALKETEIKEITVSFLQKITDLQ---NQLKQQEEDFRKQLEDEEGR 546
DL+ T +AL++ + ++I +LQ +L++++ +F+ +L+D
Sbjct: 1178 RDLEEATLQHEATAAALRKKHADSV-AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSN 1236
Query: 547 -------KAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQAL---LNEH 596
KA E + L ++ N++R+ EE F Q + E L L E
Sbjct: 1237 MEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEK 1296
Query: 597 GAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKK-QSET 655
A QL + + SY + + ++LK++++ K K+ + + ++ C L +++ + ET
Sbjct: 1297 EALISQLTRGKLSYTQQM--EDLKRQLEEEGKAKNALAH-ALQSARHDCDLLREQYEEET 1353
Query: 656 KLQEELNKVL 665
+ + EL +VL
Sbjct: 1354 EAKAELQRVL 1363
Score = 111 bits (278), Expect = 2e-24
Identities = 161/703 (22%), Positives = 301/703 (42%), Gaps = 86/703 (12%)
Query: 30 EVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRR 89
E + ++ +K + + E K++++ D + TL ++ ++E+K++ L +E D
Sbjct: 932 EEMNAELTAKKRKLEDECSELKKDID-DLELTLAKVEKEKHATENKVKNLTEEMAGLDEI 990
Query: 90 IQDLETELEKMEARLNAALREK-------TSLSANNATLEKQLIELTRTNE--------L 134
I L E + ++ AL + SLS + LE+Q+ +L + E L
Sbjct: 991 IAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDL 1050
Query: 135 LKSKFSENGNQKNLR--ILSLELMKLR-----NKRETKMRGMMAKQEGMEMKLQVTQRSL 187
++K G+ K + I+ LE KL+ K+E + +K E ++ Q+ L
Sbjct: 1051 ERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKL 1110
Query: 188 EESQGKIAQLEGKL-------VSIEKEKIDEKSETEKLLEYIEEISCASD-QVEKYKLDI 239
+E+Q +I +LE +L +EK + D E E++ E +EE A+ Q+E K
Sbjct: 1111 KENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKRE 1170
Query: 240 AQLEENLKEKNDEIL-------SLKQSLEENIVILSKQVEDLNVKCQLLEKEKE------ 286
A+ ++ ++ + L +L++ +++ L +Q+++L Q LEKEK
Sbjct: 1171 AEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEL 1230
Query: 287 DHVNRNREHNENLNAEMQNLKQKFILEQQ--------------------EREKLQQKELQ 326
D V N E A ++ + + LE Q +R KLQ + +
Sbjct: 1231 DDVTSNMEQIIKAKANLEKVSRT--LEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGE 1288
Query: 327 IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 386
+ L++++ L S L + S+ ++M K EEE K LQ + L +Q
Sbjct: 1289 LARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQ 1348
Query: 387 LEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFES 446
EEE +++AE ++L + K Q T L+E + Q L+D E+
Sbjct: 1349 YEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEA 1408
Query: 447 YKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSAL 506
A +S L+ LQ + + E A + + + ++L + + K
Sbjct: 1409 VNAKCSS----LEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEE 1464
Query: 507 KETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAE---LTEEINK 563
++E++ S ++ L +L + + + + LE E K E +N E LTE++ +
Sbjct: 1465 SQSELE----SSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGE 1520
Query: 564 WRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE-QLNKIRDSYAKLLGHQNLKQK 622
EL K QL+ ++E Q+ L E A+ E + KI + L +K +
Sbjct: 1521 GGKNVHELEKVRK----QLEVEKLELQSALEEAEASLEHEEGKILRAQ---LEFNQIKAE 1573
Query: 623 IKHVVKLKDEN-SQLKSEVSKLRCQLAKKKQSETKLQEELNKV 664
I+ + KDE Q K ++ L +ET+ + E+ +V
Sbjct: 1574 IERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRV 1616
Score = 101 bits (251), Expect = 3e-21
Identities = 149/690 (21%), Positives = 308/690 (44%), Gaps = 96/690 (13%)
Query: 42 QRFKQQKESKQN---LNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELE 98
QR KQ+ E +++ L +D T+ K K++ K+ L+++ + R +LE
Sbjct: 1213 QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYR------VKLE 1266
Query: 99 KMEARLNAALREKTSLSANNATLEKQLIE--------------LTRTNELLKSKFSENGN 144
+ + LN ++ L N L +QL E T+ E LK + E G
Sbjct: 1267 EAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGK 1326
Query: 145 QKNLRILSLE-------LMKLRNKRETKMRGMMAK----------QEGMEMKLQVTQRS- 186
KN +L+ L++ + + ET+ + + + Q + + QR+
Sbjct: 1327 AKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTE 1386
Query: 187 -LEESQGKIAQ-----------LEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEK 234
LEE++ K+AQ + K S+EK K ++E E L+ +E + A+ ++K
Sbjct: 1387 ELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDK 1446
Query: 235 YKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNRE 294
+ + ++ K+K +E S +S ++ LS ++ K + +E +H+ +
Sbjct: 1447 KQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL----FKLKNAYEESLEHLETFKR 1502
Query: 295 HNENLNAEMQNLKQ------KFILEQQE-REKLQQKELQIDSLLQQEKELSSSLHQKLCS 347
N+NL E+ +L + K + E ++ R++L+ ++L++ S L++ + K+
Sbjct: 1503 ENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILR 1562
Query: 348 FQEEMVKEKNLFEEELKQTLDELDKLQQKEEQ-AERLVKQLEEEAKSRAEELKLLEEKLK 406
Q E + K E +L + +E+++ ++ ++ + L L+ E +SR E L+ +++K++
Sbjct: 1563 AQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLR-VKKKME 1621
Query: 407 GKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQ 466
G E+E + + Q++ S+ L+D Q + A+ A+ +DLK + ++
Sbjct: 1622 GDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDD--AVRAN--DDLKENIAIVE 1677
Query: 467 EKAAKAGKNAEDVQHQILATESS----NQEYVR-----MLLDLQTKSALKETEIKEITVS 517
+ E+++ + TE S QE + LL Q S + + + E ++
Sbjct: 1678 RRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLT 1737
Query: 518 FLQ-KITDLQNQLKQQEEDFRKQLEDEE--GRKAEKENTTAELTEEINKWRLLYEELYNK 574
LQ ++ + + + EE +K + D + +KE T+ E + K +
Sbjct: 1738 QLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK------NMEQT 1791
Query: 575 TKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENS 634
K Q +LD E E+ AL ++QL K+ +L G +QK ++ +K
Sbjct: 1792 IKDLQHRLD--EAEQIAL----KGGKKQLQKLEARVRELEGELEAEQK-RNAESVKGMRK 1844
Query: 635 QLKSEVSKLRCQLAKKKQSETKLQEELNKV 664
+ + +L Q + K++ +LQ+ ++K+
Sbjct: 1845 S-ERRIKELTYQTEEDKKNLLRLQDLVDKL 1873
Score = 70.5 bits (171), Expect = 5e-12
Identities = 88/442 (19%), Positives = 191/442 (43%), Gaps = 53/442 (11%)
Query: 37 SFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETE 96
S + + FK++ ++ Q D L + V E + L E+ +++ E
Sbjct: 1493 SLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEAS 1552
Query: 97 LEKMEARLNAALREKTSLSANNATLEKQLIELT-----------RTNELLKSKFSENGNQ 145
LE E ++ LR + + A +E++L E R + L++
Sbjct: 1553 LEHEEGKI---LRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRS 1609
Query: 146 KN--LRILS-----LELMKLRNKRETKMRGMMAKQ-EGMEMKLQVTQRSLEESQGKIAQL 197
+N LR+ L M+++ +M KQ + ++ L+ TQ L+++ L
Sbjct: 1610 RNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDL 1669
Query: 198 EGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLK 257
+ + +E+ ++E E+L +E+ + E+ ++ ++ + L +N +++ K
Sbjct: 1670 KENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQK 1729
Query: 258 QSLEENIVILSKQVEDLNVKCQLLEKEKE----------DHVNRNREHNENLNAEMQNLK 307
+ +E ++ L +VE+ +C+ E++ + + + + ++ + +L +N++
Sbjct: 1730 KKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNME 1789
Query: 308 Q-----KFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQ---------KLCSFQEEMV 353
Q + L++ E+ L+ + Q+ L + +EL L K E +
Sbjct: 1790 QTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRI 1849
Query: 354 KEKNLFEEELKQTL----DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKE 409
KE EE K+ L D +DKLQ K + +R ++ EE+A + + + ++ +L E
Sbjct: 1850 KELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHEL--DE 1907
Query: 410 AELEKSSAAHTQATLLLQEKYD 431
AE E++ A +Q L + D
Sbjct: 1908 AE-ERADIAESQVNKLRAKSRD 1928
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 119 bits (298), Expect = 1e-26
Identities = 126/549 (22%), Positives = 257/549 (46%), Gaps = 56/549 (10%)
Query: 156 MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKID--- 210
MKL K + ++ ++E MK Q T+ L +S+ K +LE KLV++ +EK D
Sbjct: 831 MKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQL 890
Query: 211 -EKSETEKLL---EYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVI 266
++E+E LL E +++ A Q+E ++ + E+ +E N E+ + K+ LE+
Sbjct: 891 QVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 950
Query: 267 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQ 326
L K ++DL + +EKEK H N+ +NL E+ L + +E++ LQ+ Q
Sbjct: 951 LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEELSGLDETIAKLTREKKALQEAHQQ 1006
Query: 327 IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 386
LQ E++ +SL++ ++++ ++ E+E K +D L++ + + E +K
Sbjct: 1007 ALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVD----LERNKRKLEGDLKL 1062
Query: 387 LEEEAKSRAEELKLLEEKLKGKEAE-LEKSSAAHTQATLLLQ-----EKYDSMVQSLEDV 440
+E + + L+E+LK K+ E + S + TL LQ ++ + ++ LE+
Sbjct: 1063 AQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEE 1122
Query: 441 TAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDL 500
+ +A T + D E L E+ +AG QI + E++++ DL
Sbjct: 1123 IEAERATRAKTEKQRSDYARELEELSERLEEAGGVTST---QIELNKKREAEFLKLRRDL 1179
Query: 501 QTKSALKETEIKEITVSFLQKITDLQNQ----------LKQQEEDFRKQLEDEEG----- 545
+ + E + + + +L Q L++++ +F+ +++D
Sbjct: 1180 EEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESV 1239
Query: 546 --RKAEKENTTAELTEEINKWRLLYEELYNK-----TKPFQLQLDAFEVEKQALLNEHGA 598
KA E L +++++ R EE+ T+ +LQ +A E+ +Q L E +
Sbjct: 1240 SKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQ--LEEKES 1297
Query: 599 AQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL----KSEVSKLRCQLAKKKQSE 654
QL++ + ++ + + LK++++ K K+ + + + LR Q ++++ +
Sbjct: 1298 IVSQLSRSKQAFTQQT--EELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGK 1355
Query: 655 TKLQEELNK 663
+LQ L+K
Sbjct: 1356 AELQRALSK 1364
Score = 109 bits (272), Expect = 1e-23
Identities = 151/689 (21%), Positives = 306/689 (44%), Gaps = 78/689 (11%)
Query: 50 SKQNLNVDKDT-TLPASARKVKSSESKIRVLLQERGAQDRRIQ----DLETELEKMEARL 104
SK N++K TL + + +I+ L E Q R+Q +L +LE+ E+ +
Sbjct: 1240 SKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIV 1299
Query: 105 NAALREKTSLSANNATLEKQLIELTRTN--------------ELLKSKFSENGN-----Q 145
+ R K + + L++QL E + +LL+ ++ E Q
Sbjct: 1300 SQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQ 1359
Query: 146 KNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIE 205
+ L + E+ + R K ET + +E E K ++ QR L++S+ ++ + K S+E
Sbjct: 1360 RALSKANSEVAQWRTKYETD--AIQRTEELEEAKKKLAQR-LQDSEEQVEAVNAKCASLE 1416
Query: 206 KEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS-LKQSLEENI 264
K K + E E L+ +E + + ++K + + ++ K K +E + L+ SL+E
Sbjct: 1417 KTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKE-- 1474
Query: 265 VILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQ------KFILE-QQER 317
S+ + K + +E D + + N+NL E+ +L + K I E ++ R
Sbjct: 1475 ---SRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSR 1531
Query: 318 EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKE 377
++++ ++ I L++ + K+ Q E+ + K+ + ++ + +E+++L++
Sbjct: 1532 KQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNY 1591
Query: 378 EQA-ERLVKQLEEEAKSRAEELKLLEEKLKGKEAELE-KSSAAHTQATLLLQEKYDSMVQ 435
++ E + L+ E +SR E ++L ++K++G E+E + S A+ QA L+ S+
Sbjct: 1592 QRTVETMQSALDAEVRSRNEAIRL-KKKMEGDLNEIEIQLSHANRQAAETLKH-LRSVQG 1649
Query: 436 SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR 495
L+D + AL E DLK + + ++ +A E+++ + TE + + +
Sbjct: 1650 QLKDTQLHLDD--ALRGQE--DLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQ 1705
Query: 496 MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA 555
LLD + L T+ + + + TDL QL+ + ED + + E + + A
Sbjct: 1706 ELLDSNERVQLLHTQNTSLIHTKKKLETDLM-QLQSEVEDASRDARNAEEKAKKAITDAA 1764
Query: 556 ELTEEINK-------WRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRD 608
+ EE+ K + + L K Q +LD E E+ AL Q+ +IR+
Sbjct: 1765 MMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLD--EAEQLALKGGKKQIQKLETRIRE 1822
Query: 609 SYAKLLGHQ-----------NLKQKIKHVVKLKDENS----QLKSEVSKLRCQLAKKKQS 653
+L G Q ++++K + +E+ +L+ V KL+ ++ K+
Sbjct: 1823 LEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQ 1882
Query: 654 ETKLQEELNKVLGIKHFDPSKAFHHESKE 682
+ E+ N H + HE +E
Sbjct: 1883 AEEADEQAN-----AHLTKFRKAQHELEE 1906
Score = 103 bits (257), Expect = 5e-22
Identities = 128/679 (18%), Positives = 302/679 (44%), Gaps = 84/679 (12%)
Query: 40 KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEK 99
K + ++ E ++ +N + L A RK++ S+++ + I DLE L K
Sbjct: 919 KIKEVTERAEDEEEINAE----LTAKKRKLEDECSELK----------KDIDDLELTLAK 964
Query: 100 MEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLR 159
+E +A + +L+ + L++ + +LTR + L + +Q+ L L E K+
Sbjct: 965 VEKEKHATENKVKNLTEELSGLDETIAKLTREKKAL-----QEAHQQALDDLQAEEDKVN 1019
Query: 160 NKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLL 219
+ +TK + + + E +E L+ ++ + + +LEG L ++ +D +++ ++L
Sbjct: 1020 SLNKTKSK-LEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQL- 1077
Query: 220 EYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEE---NIVILSKQVEDLNV 276
++++K + QL+ ++++ L ++ ++E I L +++E
Sbjct: 1078 ---------DERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERA 1128
Query: 277 KCQLLEKEKEDHVNRNREHNENL---------NAEMQNLKQ-KFI-LEQQEREKLQQKEL 325
EK++ D+ E +E L E+ ++ +F+ L + E Q E
Sbjct: 1129 TRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEA 1188
Query: 326 QIDSLLQQEKELSSSLHQKLCSFQ---EEMVKEKNLFEEELKQTLDELDKLQQKEEQAER 382
+ +L ++ + + L +++ + Q +++ KEK+ F+ E+ ++ + + + E+
Sbjct: 1189 MVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEK 1248
Query: 383 LVKQLEE---EAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLED 439
+ + LE+ EA+ + EE++ +L +++ L+ + + + L+EK +S+V L
Sbjct: 1249 ICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAG---ELSRQLEEK-ESIVSQLSR 1304
Query: 440 VTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLD 499
F ++E+ ++L + + + ++ Q + E R L
Sbjct: 1305 SKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSK 1364
Query: 500 LQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENT------ 553
++ A T+ + + +++ + + +L Q+ +D +Q+E + A E T
Sbjct: 1365 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQG 1424
Query: 554 -TAELTEEINKWRLLYEELYNKTKPF-------QLQLDAFEVEKQALLNEHGAAQEQLNK 605
+L ++ + L L K + F + + + + E +A L E + +L K
Sbjct: 1425 EVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFK 1484
Query: 606 IRDSYAKLLG--------HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKK------ 651
++++Y + L ++NL+Q+I + + EN + E+ K R Q+ +K
Sbjct: 1485 LKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLA 1544
Query: 652 --QSETKLQEELNKVLGIK 668
++E L+ E K+L I+
Sbjct: 1545 LEEAEAALEHEEAKILRIQ 1563
Score = 97.1 bits (240), Expect = 5e-20
Identities = 150/714 (21%), Positives = 301/714 (42%), Gaps = 103/714 (14%)
Query: 69 VKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAAL-REKTSLSANNATLEKQLIE 127
+++ E K+ L + + +++++DLE+ LE+ E +L L R K L + ++ +++
Sbjct: 1011 LQAEEDKVNSLNKTKSKLEQQVEDLESSLEQ-EKKLRVDLERNKRKLEGDLKLAQESILD 1069
Query: 128 LTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSL 187
L + L + + E +L++K E + + Q+ K++ Q +
Sbjct: 1070 LENDKQQLDERLKKK---------DFEYCQLQSKVEDEQTLGLQFQK----KIKELQARI 1116
Query: 188 EESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEIS-CASDQVEKYKLDIAQ----- 241
EE + +I EK++ D E E+L E +EE S Q+E K A+
Sbjct: 1117 EELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLR 1176
Query: 242 --LEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK-------------- 285
LEE + + +L++ +++ L +Q+++L Q LEKEK
Sbjct: 1177 RDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSM 1236
Query: 286 -----------------EDHVNRNREHNENLNAEMQNLK-QKFILEQQERE---KLQQKE 324
ED ++ R NE + + L QK L+ + E +L++KE
Sbjct: 1237 ESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKE 1296
Query: 325 LQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLV 384
I S L + K+ + ++L EE K KN L+ + + D L+++ E+ +
Sbjct: 1297 -SIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGK 1355
Query: 385 KQL------------------EEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLL 426
+L E +A R EEL+ ++KL + + E+ A L
Sbjct: 1356 AELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASL 1415
Query: 427 QEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILAT 486
++ + +ED+ E +L A+ + + + L E K ++ +++ + +
Sbjct: 1416 EKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKES 1475
Query: 487 ESSNQEYVRMLLDLQTKSALKETE-IKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEG 545
S + E + L + AL + E +K + Q+I DL Q+ + + E E+
Sbjct: 1476 RSLSTELFK--LKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIH---ELEKS 1530
Query: 546 RK-AEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLN 604
RK E E +L E + L +EE K ++QL+ +V K + + E++
Sbjct: 1531 RKQIELEKADIQLALEEAEAALEHEE----AKILRIQLELTQV-KSEIDRKIAEKDEEIE 1585
Query: 605 KIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLK----SEVSKLRCQLAKKKQSETKLQEE 660
+++ +Y + + + ++ + V+ ++E +LK +++++ QL+ + + +
Sbjct: 1586 QLKRNYQRTV--ETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKH 1643
Query: 661 LNKVLG-IK----HFDPSKAFHHESKENFAL---KTPLKEGNTNCYRAPMECQE 706
L V G +K H D + + KE A+ + L + RA +E E
Sbjct: 1644 LRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTE 1697
Score = 73.6 bits (179), Expect = 6e-13
Identities = 110/509 (21%), Positives = 211/509 (41%), Gaps = 77/509 (15%)
Query: 51 KQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALRE 110
K+ N DK L K + S++++ L+E + + L+ E+ +L RE
Sbjct: 1445 KKQRNFDK--VLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRE 1502
Query: 111 KTSLSANNATLEKQLIELTRT-NELLKSKFS-------------------ENGNQKNLRI 150
+L A L +Q+ E +T +EL KS+ E+ K LRI
Sbjct: 1503 NKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRI 1562
Query: 151 LSLELMKLRNKRETKM-----------RGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEG 199
LEL +++++ + K+ R E M+ L RS E+ ++EG
Sbjct: 1563 -QLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEG 1621
Query: 200 KLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQS 259
L IE + + + L+++ + + + D + +E+LKE+ L++
Sbjct: 1622 DLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQ----LAI--- 1674
Query: 260 LEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREK 319
+E +L +VE+L + E+ ++ L ++ +L+ ER
Sbjct: 1675 VERRANLLQAEVEELRATLEQTERARK-------------------LAEQELLDSNER-- 1713
Query: 320 LQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL-------DELDK 372
+Q Q SL+ +K+L + L Q L S E+ ++ EE+ K+ + +EL K
Sbjct: 1714 VQLLHTQNTSLIHTKKKLETDLMQ-LQSEVEDASRDARNAEEKAKKAITDAAMMAEELKK 1772
Query: 373 LQQKEEQAERLVKQLEEEAKSRAEELKLLEE-KLKGKEAELEKSSAAHTQATLLLQEKYD 431
Q ER+ K LE+ K L E+ LKG + +++K + L+ +
Sbjct: 1773 EQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQK 1832
Query: 432 SMVQSLEDVTAQFESYKALTASEIED----LKLEN--SSLQEKAAKAGKNAEDVQHQILA 485
+S++ + K LT ED L+L++ LQ K + AE+ Q A
Sbjct: 1833 KNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANA 1892
Query: 486 TESSNQEYVRMLLDLQTKSALKETEIKEI 514
+ ++ L + + ++ + E+++ ++
Sbjct: 1893 HLTKFRKAQHELEEAEERADIAESQVNKL 1921
Score = 58.2 bits (139), Expect = 3e-08
Identities = 82/417 (19%), Positives = 175/417 (41%), Gaps = 75/417 (17%)
Query: 62 LPASARKVKSSESKIRVLLQERGA----QDRRIQDLETELEKMEARLNAALREKTSLSAN 117
L S ++++ ++ I++ L+E A ++ +I ++ EL ++++ ++ + EK
Sbjct: 1527 LEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEK------ 1580
Query: 118 NATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGME 177
+ +E+ RT E ++S +N E ++L+ K E + + +
Sbjct: 1581 DEEIEQLKRNYQRTVETMQSALDAEVRSRN------EAIRLKKKMEGDLNEIEIQLSHAN 1634
Query: 178 MKLQVTQRSLEESQGKIAQ--------------LEGKLVSIEKEKIDEKSETEKLLEYIE 223
+ T + L QG++ L+ +L +E+ ++E E+L +E
Sbjct: 1635 RQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLE 1694
Query: 224 EISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK 283
+ A E+ LD + + L +N ++ K+ LE +++ L +VED + + E+
Sbjct: 1695 QTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEE 1754
Query: 284 EKE----------DHVNRNREHNENLNAEMQNLKQ-----KFILEQQEREKLQQKELQID 328
+ + + + + ++ + +L +NL+Q + L++ E+ L+ + QI
Sbjct: 1755 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQ 1814
Query: 329 SLLQQEKELSSSLHQ---------KLCSFQEEMVKEKNLFEEELKQTL----DELDKLQQ 375
L + +EL L K E VKE EE ++ + D +DKLQ
Sbjct: 1815 KLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQV 1874
Query: 376 KEEQAERLVKQLEE-----------------EAKSRAEELKLLEEKLKGKEAELEKS 415
K + +R ++ +E EA+ RA+ + KL+ K + S
Sbjct: 1875 KVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSS 1931
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 119 bits (297), Expect = 1e-26
Identities = 151/649 (23%), Positives = 299/649 (46%), Gaps = 76/649 (11%)
Query: 61 TLPASARKVKSSESKIRVLLQERGAQDRRIQDLET-----ELEKMEARLNAALREK-TSL 114
T A ++K+ K+R+ Q + QD E E+E + A+L ++EK SL
Sbjct: 605 TETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSL 664
Query: 115 SANNATLEK----QLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMM 170
A + L+K L+E+ T L+ + +++ LE+++ + +TK+
Sbjct: 665 EAIRSKLDKAEDQHLVEMEDTLNKLQ--------EAEIKVKELEVLQAKCNEQTKVIDNF 716
Query: 171 AKQ----EGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKE----KIDEKSETEKLLEYI 222
Q E + L +++ E + ++ +L +L + EK+ +I++ +E+ K
Sbjct: 717 TSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKA---- 772
Query: 223 EEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLE 282
S + +++ +L + L+ENL E + +K++LE+ + IL ++ + + + ++
Sbjct: 773 ---SSITRELQGRELKLTNLQENLSE----VSQVKETLEKELQILKEKFAEASEEAVSVQ 825
Query: 283 KEKEDHVNRNREHNENLN---AEMQNLKQ-------KFILEQQEREKLQQKELQIDSLLQ 332
+ ++ VN+ + E N ++++ L++ KF + + E+L + + ++++ +
Sbjct: 826 RSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIA 885
Query: 333 QEKELSSSLHQKLCSFQEEM-VKEKNLFEEELKQT-LDELDKLQQK--EEQAERLVKQLE 388
+ ++S +L +E+ +KE+++ E +LK T +E QK E+ + + +
Sbjct: 886 EIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQ 945
Query: 389 EEAKSRAEELKLLEEKLKGKEAELEKS-------SAAHTQATLLLQEKYDSMVQSLEDVT 441
E AK EE K LE KL E ++E S A + +AT + K++ ++Q+L+
Sbjct: 946 EAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1005
Query: 442 AQFESYKALTASEIEDLKLENSSLQEKA--AKAGKNAEDVQHQILATESSNQEYVRMLLD 499
E E L E L+++A AKA + AED + E + L D
Sbjct: 1006 LDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLED 1065
Query: 500 LQTKSA--------LKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKE 551
+ +A LKE +K V L K +L Q+ E+FRK++E + A+K
Sbjct: 1066 TKQTNAKLQNELDTLKENNLK--NVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKS 1123
Query: 552 NTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNK-IRDSY 610
+ L EE K L EEL +++ E E+ L N+ +++ +K I+D+
Sbjct: 1124 QQLSALQEENVK---LAEEL-GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDAD 1179
Query: 611 AKLLGHQNLKQKIKHVVKLKD-ENSQLKSEVSKLRCQLAKKKQSETKLQ 658
+ Q ++ KD E +L++EV+ LR + A K + +Q
Sbjct: 1180 EEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQ 1228
Score = 94.0 bits (232), Expect = 4e-19
Identities = 145/673 (21%), Positives = 282/673 (41%), Gaps = 63/673 (9%)
Query: 32 LKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQ 91
+ G + Q++ + KQQ + L ++D A+ + L R D+ +
Sbjct: 347 ISGTTALQEALKEKQQHI--EQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVL 404
Query: 92 DLETELEKMEARLNAALREKTSLSANNATLEKQLIE----LTRTNELLKSKFSENGNQKN 147
+LE +++++ + AA REK L N EK+ +E + K +
Sbjct: 405 ELEAKMDQLRTMVEAADREKVEL-LNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEK 463
Query: 148 LRILSLE---LMKLRNKRETKMRGMMAKQEG-MEMKLQVTQR--SLEESQGKIAQLEGKL 201
RI+ LE ++++ E + R K G ++M L + Q SL+E +
Sbjct: 464 SRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQRE 523
Query: 202 VSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDI-AQLEENLKEKNDEILSLKQSL 260
++ KE + ET + + I+ + A++++ K + ++LE KE +D I K L
Sbjct: 524 ITSLKEHFGAREETHQ--KEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKL 581
Query: 261 EENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKL 320
E I + +E+L V + + E + + Q+ + +Q
Sbjct: 582 ETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAA 641
Query: 321 QQKELQI--DSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEE 378
KE++ L++ KE +SL + + ++ K ++ E++ TL++L + + K +
Sbjct: 642 HAKEMEALRAKLMKVIKEKENSLE----AIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVK 697
Query: 379 QAERLVKQLEEEAK---SRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQ--EKYDSM 433
+ E L + E+ K + +LK EEKL +A + SS ++ L Q E +
Sbjct: 698 ELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQ 757
Query: 434 VQSLEDVTAQFESYKALTAS-EIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQE 492
++ LE + ES KA + + E++ +L+ ++LQE ++ + E ++ ++ +
Sbjct: 758 IKHLE-IEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE---- 812
Query: 493 YVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKEN 552
K E E VS + + + N+L Q+EE F D E + +
Sbjct: 813 --------------KFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLAD 858
Query: 553 TTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAK 612
A+ E+ + EE K K +L+ D E+ K + G QL K+ D
Sbjct: 859 MEAKFREKDER-----EEQLIKAKE-KLENDIAEIMKMS-----GDNSSQLTKMNDELR- 906
Query: 613 LLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDP 672
L +++++ + K + S L+ + + + + +Q K EE K L K D
Sbjct: 907 -LKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDL 965
Query: 673 SKAF---HHESKE 682
K H++ +E
Sbjct: 966 EKKMETSHNQCQE 978
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 119 bits (297), Expect = 1e-26
Identities = 151/649 (23%), Positives = 299/649 (46%), Gaps = 76/649 (11%)
Query: 61 TLPASARKVKSSESKIRVLLQERGAQDRRIQDLET-----ELEKMEARLNAALREK-TSL 114
T A ++K+ K+R+ Q + QD E E+E + A+L ++EK SL
Sbjct: 640 TETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSL 699
Query: 115 SANNATLEK----QLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMM 170
A + L+K L+E+ T L+ + +++ LE+++ + +TK+
Sbjct: 700 EAIRSKLDKAEDQHLVEMEDTLNKLQ--------EAEIKVKELEVLQAKCNEQTKVIDNF 751
Query: 171 AKQ----EGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKE----KIDEKSETEKLLEYI 222
Q E + L +++ E + ++ +L +L + EK+ +I++ +E+ K
Sbjct: 752 TSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKA---- 807
Query: 223 EEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLE 282
S + +++ +L + L+ENL E + +K++LE+ + IL ++ + + + ++
Sbjct: 808 ---SSITRELQGRELKLTNLQENLSE----VSQVKETLEKELQILKEKFAEASEEAVSVQ 860
Query: 283 KEKEDHVNRNREHNENLN---AEMQNLKQ-------KFILEQQEREKLQQKELQIDSLLQ 332
+ ++ VN+ + E N ++++ L++ KF + + E+L + + ++++ +
Sbjct: 861 RSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIA 920
Query: 333 QEKELSSSLHQKLCSFQEEM-VKEKNLFEEELKQT-LDELDKLQQK--EEQAERLVKQLE 388
+ ++S +L +E+ +KE+++ E +LK T +E QK E+ + + +
Sbjct: 921 EIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQ 980
Query: 389 EEAKSRAEELKLLEEKLKGKEAELEKS-------SAAHTQATLLLQEKYDSMVQSLEDVT 441
E AK EE K LE KL E ++E S A + +AT + K++ ++Q+L+
Sbjct: 981 EAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1040
Query: 442 AQFESYKALTASEIEDLKLENSSLQEKA--AKAGKNAEDVQHQILATESSNQEYVRMLLD 499
E E L E L+++A AKA + AED + E + L D
Sbjct: 1041 LDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLED 1100
Query: 500 LQTKSA--------LKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKE 551
+ +A LKE +K V L K +L Q+ E+FRK++E + A+K
Sbjct: 1101 TKQTNAKLQNELDTLKENNLK--NVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKS 1158
Query: 552 NTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNK-IRDSY 610
+ L EE K L EEL +++ E E+ L N+ +++ +K I+D+
Sbjct: 1159 QQLSALQEENVK---LAEEL-GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDAD 1214
Query: 611 AKLLGHQNLKQKIKHVVKLKD-ENSQLKSEVSKLRCQLAKKKQSETKLQ 658
+ Q ++ KD E +L++EV+ LR + A K + +Q
Sbjct: 1215 EEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQ 1263
Score = 94.7 bits (234), Expect = 3e-19
Identities = 150/699 (21%), Positives = 286/699 (40%), Gaps = 80/699 (11%)
Query: 32 LKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQ 91
+ G + Q++ + KQQ + L ++D A+ + L R D+ +
Sbjct: 347 ISGTTALQEALKEKQQHI--EQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVL 404
Query: 92 DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRIL 151
+LE +++++ + AA REK L QL E R E L+ + E K
Sbjct: 405 ELEAKMDQLRTMVEAADREKVELL-------NQLEEEKRKVEDLQFRVEEESITKG---- 453
Query: 152 SLELM-KLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKID 210
LE KL + R ++ + ++ KL QR LE+++ + +++ +EK+
Sbjct: 454 DLETQTKLEHARIKELEQSLLFEKTKADKL---QRELEDTRVATVSEKSRIMELEKDLAL 510
Query: 211 EKSETEKLLEYIEEISCASDQVEKYKL--DIAQLEENLK----EKNDEILSLKQSLEENI 264
E +L +E A D L +I+ L+E L+ + EI SLK+
Sbjct: 511 RVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGARE 570
Query: 265 VILSKQVEDLNVKCQLLEKEKEDHVNR----NREHNENLNAEMQNLKQKFILEQQEREKL 320
K+++ L + L KE E ++ N+E+++ + L+ QQ E+L
Sbjct: 571 ETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEEL 630
Query: 321 QQK-ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKL------ 373
+ + + + EL + + + +Q E+ +N + E E++ L
Sbjct: 631 KVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMK 690
Query: 374 --QQKEEQAERLVKQLEEEAKSRAEEL-----KLLEEKLKGKEAELEKSSAAHTQATLLL 426
++KE E + +L++ E+ KL E ++K KE E+ ++ +
Sbjct: 691 VIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVI-- 748
Query: 427 QEKYDSMVQSLEDVTAQFESYKALTA---SEIEDLK--LENSSLQEKAAKAGKNAEDVQH 481
+ + S +++ E+ ++ + ++ SE++ L+ LE + Q K + KNAE +
Sbjct: 749 -DNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKA 807
Query: 482 QILATESSNQE--YVRMLLDLQTKSALKET-------------EIKEITVSFLQKITDLQ 526
+ E +E + +L S +KET E E VS + + +
Sbjct: 808 SSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETV 867
Query: 527 NQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFE 586
N+L Q+EE F D E + + A+ E+ + EE K K +L+ D E
Sbjct: 868 NKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDER-----EEQLIKAKE-KLENDIAE 921
Query: 587 VEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQ 646
+ K + G QL K+ D L +++++ + K + S L+ + + +
Sbjct: 922 IMKMS-----GDNSSQLTKMNDELR--LKERDVEELQLKLTKANENASFLQKSIEDMTVK 974
Query: 647 LAKKKQSETKLQEELNKVLGIKHFDPSKAF---HHESKE 682
+ +Q K EE K L K D K H++ +E
Sbjct: 975 AEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQE 1013
Score = 91.7 bits (226), Expect = 2e-18
Identities = 160/736 (21%), Positives = 318/736 (43%), Gaps = 133/736 (18%)
Query: 24 YDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTT------LPASARKVKSSESKIR 77
+ V+ + KG + Q + KE +Q+L +K L + S +S+I
Sbjct: 443 FRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIM 502
Query: 78 VLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNEL--- 134
L ++ + + + +L LE + + + SL ++L+++L E+TRT+
Sbjct: 503 ELEKDLALRVQEVAELRRRLESNKPAGDVDM--SLSLLQEISSLQEKL-EVTRTDHQREI 559
Query: 135 --LKSKFS--ENGNQKNLRILSLELMKLRNKRET-KMRGMMAKQEGMEMKLQVTQRSLEE 189
LK F E +QK ++ L KL + E+ K + A +E ++ + + + LE
Sbjct: 560 TSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDV-IALWKSKLET 618
Query: 190 SQGKIAQ-LEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKE 248
+ Q +E VS K E +E +L Q+EK +LD ENL+
Sbjct: 619 AIASHQQAMEELKVSFSKGLGTETAEFAEL----------KTQIEKMRLDYQHEIENLQN 668
Query: 249 KNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQ 308
+ D + +K++E L K + KEKE+ + E + +++ +
Sbjct: 669 QQDSERAAH----------AKEMEALRAKLMKVIKEKENSL-------EAIRSKLDKAED 711
Query: 309 KFILEQQER-EKLQQKELQIDSLL-------QQEKELSSSLHQKLCSFQEEMVKEKNLFE 360
+ ++E ++ KLQ+ E+++ L +Q K + + Q + EE + + +
Sbjct: 712 QHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKAT--EEKLLDLDALR 769
Query: 361 EELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEK-----S 415
+ + E+ KL+Q+ E AE+ +K LE E + + + + +L+G+E +L S
Sbjct: 770 KASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLS 829
Query: 416 SAAHTQATL-----LLQEKYD-----------SMVQSLEDVTAQFESYKALTASEIEDLK 459
+ + TL +L+EK+ SM +++ + + E + L+ S++E L+
Sbjct: 830 EVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLS-SDLEKLR 888
Query: 460 ----------LENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKET 509
E +E+ KA + E+ +I+ N + + D + LKE
Sbjct: 889 ENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND---ELRLKER 945
Query: 510 EIKEITV---------SFLQK-ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTE 559
+++E+ + SFLQK I D+ + +Q +++ K+ E+E K E E ++L +
Sbjct: 946 DVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEE---KKELERKLSDLEK 1002
Query: 560 EIN-------KWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAK 612
++ + + YE ++TK ++ + ++ LL+ +++L R+ +
Sbjct: 1003 KMETSHNQCQELKARYERATSETKTKHEEI--LQNLQKTLLD----TEDKLKGAREENSG 1056
Query: 613 LLGHQNLKQKIKHVVKLKDENS---------QLKSEVSKLRCQLAKKKQSETKLQEEL-- 661
LL Q L++ K K K + Q+ E ++ L KQ+ KLQ EL
Sbjct: 1057 LL--QELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDT 1114
Query: 662 ---NKVLGIKHFDPSK 674
N + ++ + SK
Sbjct: 1115 LKENNLKNVEELNKSK 1130
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 118 bits (295), Expect = 2e-26
Identities = 166/740 (22%), Positives = 322/740 (43%), Gaps = 121/740 (16%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDL----E 94
QK++ F Q E+++N + + +T + ++ +K+ +L Q+ + R+ L E
Sbjct: 1857 QKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAE 1916
Query: 95 TELEKMEARLNAALREKTSLSAN------NATLEKQLIELTRTNELLKSKFSENGNQKNL 148
E + +E RL L E N +A ++ +L+E N LK SE +K
Sbjct: 1917 EEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKN--LKKCVSELEEEKQ- 1973
Query: 149 RILSLELMKLRNKRETKMRGMMA-------KQEGMEMKLQVTQRSLEESQGKIAQLEGKL 201
+L+K + K E+++R K+ G + + Q L+E Q ++ QL+
Sbjct: 1974 -----QLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDC 2028
Query: 202 VSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLE 261
+ + EKI T K LE+++ S +E K ++AQ E+ K+ E+ S K L+
Sbjct: 2029 IRYQ-EKISALERTVKALEFVQTES--QKDLEITKENLAQAVEHRKKAQAELASFKVLLD 2085
Query: 262 ENIVILSKQVEDLNVKCQL-LEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQE---- 316
+ ++ + D N+K + L+ KE ++ ++ +E+L ++ ++K + E++
Sbjct: 2086 DTQSEAARVLAD-NLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEK 2144
Query: 317 -----REKLQQKE----LQI-----DSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEE 362
REK+ +E +Q+ D +QQ +E S +L +F + M + +++
Sbjct: 2145 LDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSM----SSLQDD 2200
Query: 363 LKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEK-------- 414
+ +DE K ++K A ++ EEE + + + +L+++L+ +E+
Sbjct: 2201 RDRVIDEAKKWERKFSDA---IQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRL 2257
Query: 415 -------SSAAHTQATL------LLQEKYDSMVQSLEDVTAQFESYK---ALTASEIEDL 458
S A T+ L LQ + ++ LE+ + S + A SE++ L
Sbjct: 2258 EHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSL 2317
Query: 459 KLENSSLQ---EKAAKAGKNAEDVQHQILAT-ESSNQEYVRMLLDLQTKSAL-----KET 509
K + + L EK + N E + Q A ++S Y ++ DLQ L +E
Sbjct: 2318 KDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEI 2377
Query: 510 EIKEITVSFL--------------------QKITDLQNQLKQQEEDFRKQLEDEEGRKAE 549
+KE + L ++I +L+N L Q+EE+ LE+E + +
Sbjct: 2378 NMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEE-NIVLEEENKKAVD 2436
Query: 550 KENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDS 609
K N E + I K E + K QLD+F +L N+ ++ +
Sbjct: 2437 KTNQLMETLKTIKK-----ENIQQKA-----QLDSFVKSMSSLQNDRDRIVGDYQQLEER 2486
Query: 610 YAKLL--GHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGI 667
+ ++ Q +++ KLK+E L+S + L + AK + +E+LN+V+ I
Sbjct: 2487 HLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITI 2546
Query: 668 KHFDPSKAFHHESKENFALK 687
K + + ++N L+
Sbjct: 2547 KDSQQKQLLEVQLQQNKELE 2566
Score = 109 bits (273), Expect = 8e-24
Identities = 153/650 (23%), Positives = 279/650 (42%), Gaps = 71/650 (10%)
Query: 46 QQK--ESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEK---M 100
QQK ++ Q N + + L + SS++++ L E + ++ DL LEK
Sbjct: 2275 QQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQ 2334
Query: 101 EARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRN 160
+ L +R++ + N+ +QL + + L S+ E N K +I+SL L
Sbjct: 2335 KGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISL----LSG 2390
Query: 161 KRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLE 220
K E A Q + Q + ++E + ++Q E + + +E+E +T +L+E
Sbjct: 2391 KEE-------AIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLME 2443
Query: 221 YIEEISCASDQVEKYKLD-IAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQ 279
++ I + Q +K +LD + +L+ D I+ Q LEE + + + + L +
Sbjct: 2444 TLKTIKKENIQ-QKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAA 2502
Query: 280 LLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKL------QQKELQIDSLLQQ 333
+ ++ + R H ++LN+E L + I +++ ++ QQK+L ++ LQQ
Sbjct: 2503 AENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQL-LEVQLQQ 2561
Query: 334 EKELS---SSLHQKLCSFQ---EEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQL 387
KEL + L +KL + E++ + N +EE + E++ L+ Q R V L
Sbjct: 2562 NKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTAL 2621
Query: 388 EEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESY 447
+EE L L +LK KE E+ + SA + + + LE+ +
Sbjct: 2622 QEEG-----TLGLYHAQLKVKEEEVHRLSALFSSS--------QKRIAELEEELVCVQKE 2668
Query: 448 KALTASEIED-LKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSAL 506
A EIED LK E L A E + ++ E R L++++ K +
Sbjct: 2669 AAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERV-------AELARDLVEMEQKLLM 2721
Query: 507 KETEIKEITV---SFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKE-NTTAELTEE-- 560
E K +T SF + ++ LQN E+ DE RK + A+L E+
Sbjct: 2722 VTKENKGLTAQIQSFGRSMSSLQNSRDHANEEL-----DELKRKYDASLKELAQLKEQGL 2776
Query: 561 INKWR--LLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN 618
+N+ R LL E ++ + L E Q LL++ +++ DSY
Sbjct: 2777 LNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSY------NQ 2830
Query: 619 LKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIK 668
++ K + L++E L +E+ K R K++S + +V +K
Sbjct: 2831 VQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLK 2880
Score = 103 bits (256), Expect = 7e-22
Identities = 158/716 (22%), Positives = 308/716 (43%), Gaps = 113/716 (15%)
Query: 40 KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEK 99
+ + K+ K ++ L++ + T + + + ES++ +E+ R+ L+ E +K
Sbjct: 1492 RKEALKENKSLQEELSLARGT-IERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDK 1550
Query: 100 MEARLNAALREKTSLSANNATLEKQLIELTRTNELL--------KSKFSENGN------- 144
+ ++ +L E SLS++ +L+ L LT E L SK +E+
Sbjct: 1551 LITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKE 1610
Query: 145 -QKNLRILSLELMKLRNKRETKMRGMMA-KQEGMEM--KLQVTQRSLEESQGKIAQLEGK 200
QK IL + N+ E + A +QE E+ KL+ T+ + +E++ ++ + E +
Sbjct: 1611 LQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQE 1670
Query: 201 LVSI-EKEKIDEKSETEKLLEYIEE-------ISCASDQVE-------------KYKLDI 239
+ + EK + KS+ +K+LE EE + A D + K +L+
Sbjct: 1671 MEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELER 1730
Query: 240 AQLE-ENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNR----- 293
++E E L +K ++S K SL E + L Q+E NV Q + E H N+
Sbjct: 1731 VKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEG-NVSKQANLEATEKHDNQTNVTEEG 1789
Query: 294 --------EHNENLNAEMQNLKQKFILEQQEREKLQQKEL----QIDSLLQQEKELSSSL 341
E ++L+ + + + + K+ +I++ LQQ +L +
Sbjct: 1790 TQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERI 1849
Query: 342 ------HQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEA---- 391
QK F + + EKN ++ EL LQ++ + L +Q++EE
Sbjct: 1850 AGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVT 1909
Query: 392 --KSRAEELKL-LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVT-AQFESY 447
K AEE K LEE+L + AEL S + Q DVT AQ ++
Sbjct: 1910 KLKETAEEEKDDLEERLMNQLAELNGSIGNYCQ-----------------DVTDAQIKN- 1951
Query: 448 KALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI----------LATESSNQEYVRML 497
L SE+++LK S L+E+ + K V+ +I E N+ + + L
Sbjct: 1952 -ELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKEL 2010
Query: 498 LDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQE---EDFRKQLEDEEGRKAEKENTT 554
+L + + ++++ + + +KI+ L+ +K E + +K LE + A+
Sbjct: 2011 QELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHR 2070
Query: 555 AELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKL- 613
+ E+ +++L ++ +++ ++ D +++K+ N+ + K D +L
Sbjct: 2071 KKAQAELASFKVLLDD--TQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLE 2128
Query: 614 -LGHQNLKQKIKHVVK---LKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVL 665
++LK+K K L+ E L+ + +++ L KK + +LQE L+ +
Sbjct: 2129 QAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTV 2184
Score = 96.7 bits (239), Expect = 7e-20
Identities = 137/612 (22%), Positives = 265/612 (43%), Gaps = 83/612 (13%)
Query: 75 KIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNEL 134
+I L E ++D +I+ L+ EL+ ++ + + SL + E +++E
Sbjct: 797 QIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRH 856
Query: 135 LKSKFSENG---NQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQ 191
+ SK E +QK L I ++ + L KR+ + +Q E QVT+ S ++
Sbjct: 857 ISSKVEELSQALSQKELEITKMDQLLLEKKRDVET----LQQTIEEKDQQVTEISFSMTE 912
Query: 192 GKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND 251
K+V + +EK E + L E + +S A + ++ + ++ LK+ D
Sbjct: 913 --------KMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYD 964
Query: 252 EILSL----KQSLEENIVILSKQVEDLNVKCQ---LLEKEKEDHVNRNREHNENLNAEMQ 304
E+ K+ L+ +L K+ E K Q + KE V+R E NL E
Sbjct: 965 EMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDES- 1023
Query: 305 NLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELK 364
K++ L + ER ++++ + ++ EK ++S Q++ + ++ + EK E EL+
Sbjct: 1024 --KKEIPLSETERGEVEEDK---ENKEYSEKCVTSKC-QEIEIYLKQTISEK---EVELQ 1074
Query: 365 QTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATL 424
+L++ EEQ + LVKQ+ + + + ++ LL+ ++ +A ++K ++T A+
Sbjct: 1075 HIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDAS- 1133
Query: 425 LLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQIL 484
DS+ E V T S E K E L+EK K E +Q ++
Sbjct: 1134 ----DGDSVALVKETVVIS----PPCTGSS-EHWKPE---LEEKILALEKEKEQLQKKLQ 1181
Query: 485 ATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEE 544
+S K+ LK+ + KE L+ +LKQQ++D+ + E +
Sbjct: 1182 EALTSR------------KAILKKAQEKE---------RHLREELKQQKDDYNRLQEQFD 1220
Query: 545 GRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF-------EVEKQALLNEHG 597
+ E EN + +++ + ++ E + P Q ++ E +A H
Sbjct: 1221 EQSKENEN----IGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHT 1276
Query: 598 AAQEQLNKIRD------SYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKK 651
+ N D + L G ++ Q + +++ E +L+ +VS +L KK
Sbjct: 1277 QPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKS 1336
Query: 652 QSETKLQEELNK 663
+ +LQE++NK
Sbjct: 1337 EEVFQLQEQINK 1348
Score = 89.4 bits (220), Expect = 1e-17
Identities = 147/678 (21%), Positives = 275/678 (40%), Gaps = 95/678 (14%)
Query: 87 DRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIE--------LTRTNELLKSK 138
+ +I LE E E+++ +L AL + ++ E+ L E R E +
Sbjct: 1163 EEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQ 1222
Query: 139 FSENGN-QKNLRILSLELMKLRNKR--ETKMRGMMAKQEGMEMKL------QVTQRSLEE 189
EN N LR L +++ + + + T + + G+E L TQ LE
Sbjct: 1223 SKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLES 1282
Query: 190 S---------------QG--KIAQLEGKLVSIEKEKIDEK----SETEKLLEYIEEISCA 228
+ QG +AQ++ +L IE EK++ + S T +L + EE+
Sbjct: 1283 NLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQL 1342
Query: 229 SDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILS--KQVEDLNVKCQLLEK--- 283
+Q+ K L+I L+ E SL+Q LE + + ++ + + +L K L+K
Sbjct: 1343 QEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLIS 1402
Query: 284 EKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQ 343
+KE+ V+ A + ++ + I+EQ++ K +L++ + ++ E L
Sbjct: 1403 KKEEDVSYLSGQLSEKEAALTKIQTE-IIEQEDLIKALHTQLEMQA--KEHDERIKQLQV 1459
Query: 344 KLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLE- 402
+LC +++ EE+ + ++Q+K + A K+ +E KS EEL L
Sbjct: 1460 ELCEMKQK--------PEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARG 1511
Query: 403 --EKLKGKEAELEKSSAAHTQAT-------LLLQEKYDSMVQSLEDVTAQFESYKALTAS 453
E+L A++E +A + LLQE+ D ++ ++ + +S +S
Sbjct: 1512 TIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSL----SS 1567
Query: 454 EIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIK- 512
E LKL L E K K E ++ +A + QE + K KE EI
Sbjct: 1568 SCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQE--------KHKELQKEYEILL 1619
Query: 513 ---EITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYE 569
E + ++I + ++Q++++ +L E K E E E +E+ + + E
Sbjct: 1620 QSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMK---E 1676
Query: 570 ELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKL 629
++ K Q ++ E E L E A + + ++ + +
Sbjct: 1677 KMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETL------------LSSNASM 1724
Query: 630 KDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTP 689
K+E ++K E L + + L EE+ + + SK + E+ E +T
Sbjct: 1725 KEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTN 1784
Query: 690 LKEGNTNCYRAPMECQES 707
+ E T E Q+S
Sbjct: 1785 VTEEGTQSIPGETEEQDS 1802
Score = 88.6 bits (218), Expect = 2e-17
Identities = 128/665 (19%), Positives = 278/665 (41%), Gaps = 83/665 (12%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELE 98
+K +++KE Q + T+ A +K + E +R L+++ R+Q+ E
Sbjct: 1164 EKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQS 1223
Query: 99 KMEARLNAALRE-----------------KTSLSANNATLEKQLIELTR---TNELLKSK 138
K + LR+ + ++ LE+ L + T T +L+S
Sbjct: 1224 KENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESN 1283
Query: 139 FSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLE 198
+ + +L+ + + +++ + A++ +E+K+ T L + ++ QL+
Sbjct: 1284 LCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQ 1343
Query: 199 GKLVSIEKEKIDEKSETEKLLEYIEEISCASDQ--VEKYKLDIAQLEE--NLKEKNDEIL 254
+ I K+ ++ E+ K + + E+ S Q +E +L IA LE L+ K DE+
Sbjct: 1344 EQ---INKQGLE--IESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQ 1398
Query: 255 SLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ 314
L EE++ LS Q+ + ++ E + + + + L + + ++ Q
Sbjct: 1399 KLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQ 1458
Query: 315 QEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQ 374
E +++QK +I + ++++ L L S ++E +KE +EEL +++L
Sbjct: 1459 VELCEMKQKPEEIGEESRAKQQIQRKLQAALIS-RKEALKENKSLQEELSLARGTIERLT 1517
Query: 375 QKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKS---SAAHTQATLLLQEKYD 431
+ E V +E + L LL+E+ E+++S + + + + L+ +
Sbjct: 1518 KSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALE 1577
Query: 432 SMVQSLEDVTAQFESYKALTASEI-------EDLKLENSSLQEKAAKAGKNAEDVQHQIL 484
+ + E + + ES K+ +E ++L+ E L + AE +QH +
Sbjct: 1578 GLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVE 1637
Query: 485 ATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEE 544
A QE L T++ KETE +++ + + ++++ +E RK + ++
Sbjct: 1638 AVRQEKQELYGKL--RSTEANKKETE---------KQLQEAEQEMEEMKEKMRKFAKSKQ 1686
Query: 545 GRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLN 604
+ E E L E++ D + + LL+ + + +E+L
Sbjct: 1687 QKILELEEENDRLRAEVHP-----------------AGDTAKECMETLLSSNASMKEELE 1729
Query: 605 KIRDSYAKLLGHQNLKQKIKHVVKLKDENS--------QLKSEVSK-LRCQLAKKKQSET 655
+++ Y + L +K + ++ KD S Q++ VSK + +K ++T
Sbjct: 1730 RVKMEY------ETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQT 1783
Query: 656 KLQEE 660
+ EE
Sbjct: 1784 NVTEE 1788
Score = 71.2 bits (173), Expect = 3e-12
Identities = 143/682 (20%), Positives = 268/682 (39%), Gaps = 132/682 (19%)
Query: 30 EVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRR 89
E L ++ + SQ+ KQ E + N + + K+K SE L + A
Sbjct: 2538 EDLNQVITIKDSQQ-KQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEE 2596
Query: 90 IQDLETELEKMEARLN------AALREKTSLSANNATLEKQLIELTRTNELLKSKFSENG 143
QDL E+E ++ ++ AL+E+ +L +A L+ + E+ R + L S
Sbjct: 2597 KQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSS------ 2650
Query: 144 NQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMK-----LQVTQRSLEESQGKIAQLE 198
+QK + L EL+ ++ K K G + + E+K + + E ++ ++A+L
Sbjct: 2651 SQKRIAELEEELVCVQ-KEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELA 2709
Query: 199 GKLVSIEKEKIDEKSETEKLLEYIEEISC-----------ASDQVEKYKL-------DIA 240
LV +E++ + E + L I+ A++++++ K ++A
Sbjct: 2710 RDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELA 2769
Query: 241 QLEEN--LKEKNDEILS-------------------LKQSL---EENIVILSKQVEDLNV 276
QL+E L + D +LS L Q L +E ++ LS Q+ED
Sbjct: 2770 QLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYN 2829
Query: 277 KCQLLEK------EKEDHV--------------NRNREHNENLNAEMQNLKQKFILEQQE 316
+ Q K + DH+ R+ AE+Q+LK+ Q +
Sbjct: 2830 QVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQND 2889
Query: 317 REKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEK--NLFEEELKQT----LDEL 370
R++L ++ + Q + + LH QE K K + +EEL+Q EL
Sbjct: 2890 RDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHEL 2949
Query: 371 DKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKY 430
+L+ ++ E ++++E+ + L+ EL +SS++ TQ + ++
Sbjct: 2950 HQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIREL-RSSSSQTQPLKVQYQRQ 3008
Query: 431 DSMVQSLEDVTAQFESYKAL--------TASEIEDLKLENSSLQEKAAKAGKNAEDVQHQ 482
S S +Q Y+ + EI +L L ++ + + Q
Sbjct: 3009 ASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQ 3068
Query: 483 ILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFL----------------------- 519
+ T S +E + DL A+ E +++E+ L
Sbjct: 3069 LCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEE 3128
Query: 520 -----QKITDLQNQL---KQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEEL 571
Q ++ Q QL +Q+ + RK LE+E ++ EN + E+I RL + E
Sbjct: 3129 LREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIR--RLEHSEW 3186
Query: 572 YNKTKPFQLQLDAFEVEKQALL 593
+ P + + ++QALL
Sbjct: 3187 DSSRTPI---IGSCGTQEQALL 3205
Score = 70.9 bits (172), Expect = 4e-12
Identities = 156/761 (20%), Positives = 301/761 (39%), Gaps = 132/761 (17%)
Query: 42 QRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQ-----DLETE 96
Q+ ++++E L T A + E R Q R +D +Q D+ETE
Sbjct: 190 QQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETE 249
Query: 97 LEKMEARLNAALREKTSLSANNAT----LEKQLIELTRTNELLKSKFSENGNQKNLRILS 152
+++ L L E A L+++L + N++L + + + N
Sbjct: 250 MQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNT---- 305
Query: 153 LELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKI--------------AQLE 198
LRN ET+ E ME+++ + S Q ++ A+LE
Sbjct: 306 -----LRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELE 360
Query: 199 GKLVSIE-KEKIDEKSETEKLLEYI---EEISCASDQVEKYKLDIAQLEENLKEKNDEIL 254
+ ++E K K + + +T +L +E+ A D ++ Q + L++KN++ +
Sbjct: 361 SRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKD------QNSKLLQDKNEQAV 414
Query: 255 SLKQS---LEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNA----EMQNLK 307
Q+ LE+ + SK++ + L + E + +NE A + +L+
Sbjct: 415 QSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQ 474
Query: 308 QKFILEQQEREKLQQKELQIDSLLQQEKELSSSLH----QKLCSFQEEMVKEKNLFEEEL 363
++ + + E+ L ++++ L + ++LSS + Q + V E ++ +
Sbjct: 475 KRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIAN 534
Query: 364 KQTLDE----LDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAE-------- 411
K++ D L+ Q + + L E K EE+ L+ +L+GK AE
Sbjct: 535 KRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLD 594
Query: 412 ------LEKSSAAHTQATLLLQE---------KYDSMVQSLEDVTAQFESYKALTASEI- 455
+E A + + L++ +S + ++E A E +++ T+ EI
Sbjct: 595 QKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTE-HQSRTSEEIS 653
Query: 456 -EDLKLENSSLQEKAAKAGKNAEDV-----------QHQILATE---SSNQEYVRMLLDL 500
D +E S ++ K+ D+ + QIL E QE LD
Sbjct: 654 LNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDE 713
Query: 501 QTK-----------------------SALKETEIKEIT-VSFLQKITDLQNQLKQQEEDF 536
+ K +AL E + ++ V L +T+L+ Q+KQ E +
Sbjct: 714 KAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNL 773
Query: 537 RKQLEDEEGRKAEKENTTAE---LTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALL 593
E E R+ + E+ TA LTE+I+ + + K + Q +LD +++
Sbjct: 774 ---AEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQS 830
Query: 594 NEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQS 653
+ Q QL L G + ++ V +L SQ + E++K+ L +KK+
Sbjct: 831 TLIRSLQSQLQNKESEV--LEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRD 888
Query: 654 ETKLQ---EELNKVLGIKHFDPSKAFHHESKENFALKTPLK 691
LQ EE ++ + F ++ ++E F+L +K
Sbjct: 889 VETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIK 929
Score = 70.1 bits (170), Expect = 7e-12
Identities = 83/418 (19%), Positives = 182/418 (43%), Gaps = 24/418 (5%)
Query: 286 EDHVNRNREHNENLNAEMQNL-KQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 344
++ V + E L E++++ +QK + QQ+ E LQ++ D+ +++ K + +
Sbjct: 47 QEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTS 106
Query: 345 LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 404
L + EEM + Q+ ++L K + + E +++++ + + + E + L+ +
Sbjct: 107 LNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQ 166
Query: 405 LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS 464
L +AE S+ + ++++++ + + + AQ +A A++
Sbjct: 167 LTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQ--------QV 218
Query: 465 LQEKAAKAGKNA---EDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQK 521
++EK A+ ED Q++ E + L LQ K L+E E E V Q
Sbjct: 219 VREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRK--LEEHE--ESLVGRAQV 274
Query: 522 ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK--WRLLYEELYNKTKPFQ 579
+ LQ +L E+ R Q+ ++ ++ E E+ T T E + ++L E++ + +
Sbjct: 275 VDLLQQELTAAEQ--RNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERK 332
Query: 580 LQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKL--LGHQNLKQKIKHVVKLKDENSQLK 637
L + E LL + A + ++ Y+ L +++K H++ L+ +L+
Sbjct: 333 LSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQ 392
Query: 638 SEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNT 695
S L+ Q +K Q K ++ + I+ + + F + PL++ T
Sbjct: 393 SACDALKDQNSKLLQD--KNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHET 448
Score = 69.7 bits (169), Expect = 9e-12
Identities = 120/562 (21%), Positives = 249/562 (44%), Gaps = 76/562 (13%)
Query: 80 LQERGAQ-DRRIQDLETELEKMEARL---NAALREKTSLSANNATLEK--QLIELTRTNE 133
+QER A ++ + +L+ + + + +L + AL+E+ + N K +LT N+
Sbjct: 50 VQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNK 109
Query: 134 LLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGK 193
++ ++ G S E + +K T+ EM+++ + L+E +
Sbjct: 110 YIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEE----------EMEIEKIKHKLQEKEEL 159
Query: 194 IAQLEGKLVSIEKEKIDEKSE--------TEKLLEYIEEISCASDQVEKYKLDIAQLEEN 245
I+ L+ +L + E+ + S ++L E E IS Q+ + + + A ++
Sbjct: 160 ISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQA-AQQV 218
Query: 246 LKEKNDEILSLKQSLEENIVILSKQVE---DLNVKCQLLEKEKEDHVNRNREHNENL--N 300
++EK+ + + E+ ++ L Q + ++ K ++L+++ E EH E+L
Sbjct: 219 VREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLE-------EHEESLVGR 271
Query: 301 AEMQNLKQKFILEQQER-----EKLQQKELQIDSL---LQQEKELSSSLHQKLCSFQEEM 352
A++ +L Q+ + ++R ++LQQ E + ++L ++ E+E S L +K+ E
Sbjct: 272 AQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKM----ELE 327
Query: 353 VKEKNL----FEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK 408
V E+ L +EE+ L++ ++ Q + + E LE++ K+ EE L+
Sbjct: 328 VAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKT 387
Query: 409 EAELEKS-SAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQE 467
EL+ + A Q + LLQ+K + VQS + + Q E + EI L LQ+
Sbjct: 388 GQELQSACDALKDQNSKLLQDKNEQAVQSAQTI-QQLEDQLQQKSKEISQF-LNRLPLQQ 445
Query: 468 KAAKAGKNAEDVQHQ--ILATESSNQEYVRMLLDLQTK------SALKETEIKEITVSFL 519
+ + DV ++ TE + + +++L+ + S+++ E+K
Sbjct: 446 HETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLS 505
Query: 520 QKITDLQNQLKQQEED------------FRKQLEDEEGRKAEKENTTAELTEEINKWRLL 567
+IT L+ Q + E D ++ EE + ENT ++ +E++ L
Sbjct: 506 SQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLE 565
Query: 568 YEELYNKTKPFQLQLDAFEVEK 589
+E + +LQL E+
Sbjct: 566 MKEAQEEIAFLKLQLQGKRAEE 587
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 117 bits (293), Expect = 4e-26
Identities = 121/546 (22%), Positives = 248/546 (45%), Gaps = 50/546 (9%)
Query: 156 MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 213
MKL K + ++ ++E MK + T+ L +++ K +LE K+V++ +EK D +
Sbjct: 834 MKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQL 893
Query: 214 ETEKLLEYIEEISCASDQVEKYKL-------DIAQLEENLKEKNDEILSLKQSLEENIVI 266
+ + + + + DQ+ K K+ ++ + E+ +E N E+ + K+ LE+
Sbjct: 894 QVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 953
Query: 267 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQ 326
L K ++DL + +EKEK H N+ +NL EM L + +E++ LQ+ Q
Sbjct: 954 LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1009
Query: 327 IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 386
LQ E++ ++L + ++++ + E+E K +D L++ + + E +K
Sbjct: 1010 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMD----LERAKRKLEGDLKL 1065
Query: 387 LEEEAKSRAEELKLLEEKLKGKEAELE--KSSAAHTQAT-LLLQEKYDSMVQSLEDVTAQ 443
+E + + L+EKLK KE E+ +S QA + LQ+K + +E++ +
Sbjct: 1066 AQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEE 1125
Query: 444 FESYKALTA---SEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDL 500
E+ +A A + DL E + E+ +AG QI + E+ +M DL
Sbjct: 1126 IEAERASRAKAEKQRSDLSRELEEISERLEEAG---GATSAQIEMNKKREAEFQKMRRDL 1182
Query: 501 QTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEE 560
+ + E + + +L Q+ + +++LE E+ + + A E
Sbjct: 1183 EEATLQHEATAATLRKKHADSVAELGEQIDNLQR-VKQKLEKEKSEMKMEIDDLASNMET 1241
Query: 561 INKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLL------ 614
++K + E++ + ++ E E+Q L+N+ A + +L Y++ L
Sbjct: 1242 VSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTL 1301
Query: 615 ------GHQNLKQKIKHVVKLKDENSQLKSEVSK-----------LRCQLAKKKQSETKL 657
G Q Q+I+ + + +E + KS ++ LR Q ++++++ +L
Sbjct: 1302 VSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAEL 1361
Query: 658 QEELNK 663
Q ++K
Sbjct: 1362 QRAMSK 1367
Score = 106 bits (264), Expect = 8e-23
Identities = 138/682 (20%), Positives = 302/682 (44%), Gaps = 90/682 (13%)
Query: 40 KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEK 99
K + ++ E ++ +N + L A RK++ S+++ + I DLE L K
Sbjct: 922 KIKEVTERAEDEEEINAE----LTAKKRKLEDECSELK----------KDIDDLELTLAK 967
Query: 100 MEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLR 159
+E +A + +L+ A L++ + +LT+ + L + +Q+ L L E K+
Sbjct: 968 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKAL-----QEAHQQTLDDLQAEEDKVN 1022
Query: 160 NKRETKMR---------GMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKID 210
+ K++ G + +++ + M L+ +R L E K+AQ + +K+++D
Sbjct: 1023 TLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKL-EGDLKLAQESTMDIENDKQQLD 1081
Query: 211 EKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQ 270
EK + ++ E+S ++E + QL++ +KE I L++ +E +K
Sbjct: 1082 EKLKKKEF-----EMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKA 1136
Query: 271 VEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQID-- 328
+ + L +E E+ R E +A+++ K++ Q+ R L++ LQ +
Sbjct: 1137 EKQRSD----LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEAT 1192
Query: 329 --SLLQQEKELSSSLHQKLCSFQ---EEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 383
+L ++ + + L +++ + Q +++ KEK+ + E+ ++ + + + E++
Sbjct: 1193 AATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKM 1252
Query: 384 VKQLEE---EAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSL--- 437
+ LE+ E K++ EE + L L + A L+ S +++ L EK D++V L
Sbjct: 1253 CRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQ---LDEK-DTLVSQLSRG 1308
Query: 438 -EDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRM 496
+ T Q E K EI+ S+L + + + ++ Q + + E R
Sbjct: 1309 KQAFTQQIEELKRQLEEEIK----AKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRA 1364
Query: 497 LLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAE 556
+ ++ A T+ + + +++ + + +L Q+ +D + +E + A E T
Sbjct: 1365 MSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQR 1424
Query: 557 LTEEINKWRLLYEE-------LYNKTKPF-------QLQLDAFEVEKQALLNEHGAAQEQ 602
L E+ + E L K + F + + + E +A E + +
Sbjct: 1425 LQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTE 1484
Query: 603 LNKIRDSYAKLLG--------HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKK--- 651
L KI+++Y + L ++NL+Q+I + + E + E+ K++ Q+ ++K
Sbjct: 1485 LFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSEL 1544
Query: 652 -----QSETKLQEELNKVLGIK 668
++E L+ E K+L I+
Sbjct: 1545 QAALEEAEASLEHEEGKILRIQ 1566
Score = 99.4 bits (246), Expect = 1e-20
Identities = 139/660 (21%), Positives = 303/660 (45%), Gaps = 72/660 (10%)
Query: 50 SKQNLNVDKDT-TLPASARKVKSSESKIRVLLQERGAQDRRIQ----DLETELEKMEARL 104
SK N++K L ++K+ E + + L+ + AQ R+Q + +L++ + +
Sbjct: 1243 SKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLV 1302
Query: 105 NAALREKTSLSANNATLEKQLIELTRTN--------------ELLKSKFSENGN-----Q 145
+ R K + + L++QL E + +LL+ ++ E Q
Sbjct: 1303 SQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQ 1362
Query: 146 KNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIE 205
+ + + E+ + R K ET + +E E K ++ QR L++++ + + K S+E
Sbjct: 1363 RAMSKANSEVAQWRTKYETD--AIQRTEELEEAKKKLAQR-LQDAEEHVEAVNAKCASLE 1419
Query: 206 KEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIV 265
K K ++E E L+ +E + A ++K + + ++ K+K +E + ++ ++
Sbjct: 1420 KTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESR 1479
Query: 266 ILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKEL 325
LS ++ K + +E D + + N+NL E+ +L ++ + +L++ +
Sbjct: 1480 SLSTEL----FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKK 1535
Query: 326 QIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD-KLQQKEEQAERLV 384
Q++ Q++ EL ++L + S + E K + + EL Q E+D K+ +K+E+ +++
Sbjct: 1536 QVE---QEKSELQAALEEAEASLEHEEGKILRI-QLELNQVKSEVDRKIAEKDEEIDQMK 1591
Query: 385 KQ-----------LEEEAKSRAEELKLLEEKLKG--KEAELEKSSAAHTQATLLLQEKYD 431
+ L+ E +SR + ++L ++K++G E E++ + A A L Y
Sbjct: 1592 RNHIRIVESMQSTLDAEIRSRNDAIRL-KKKMEGDLNEMEIQLNHANRMAAEAL--RNYR 1648
Query: 432 SMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQ 491
+ L+D + AL + E DLK + + ++ +A E+++ + TE S +
Sbjct: 1649 NTQAILKDTQLHLDD--ALRSQE--DLKEQLAMVERRANLLQAEIEELRATLEQTERSRK 1704
Query: 492 EYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKE 551
+ LLD + L T+ + + + TD+ +Q++ + ED ++ + E + +
Sbjct: 1705 IAEQELLDASERVQLLHTQNTSLINTKKKLETDI-SQIQGEMEDIIQEARNAEEKAKKAI 1763
Query: 552 NTTAELTEEINK-------WRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLN 604
A + EE+ K + + L K Q +LD E E+ AL ++Q+
Sbjct: 1764 TDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLD--EAEQLAL----KGGKKQIQ 1817
Query: 605 KIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKV 664
K+ +L G +QK ++V +K + +V +L Q + +++ +LQ+ ++K+
Sbjct: 1818 KLEARVRELEGEVESEQK-RNVEAVKGLRKH-ERKVKELTYQTEEDRKNILRLQDLVDKL 1875
Score = 98.6 bits (244), Expect = 2e-20
Identities = 145/700 (20%), Positives = 305/700 (43%), Gaps = 97/700 (13%)
Query: 32 LKGPVSFQKSQRFKQQKESKQ---NLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDR 88
L+G + +K R ++ ++ +L + +++T+ K + E + + G Q +
Sbjct: 1038 LEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSK 1097
Query: 89 RIQD-------LETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSE 141
I+D L+ ++++++AR+ E + A+ A EKQ +L+R E + + E
Sbjct: 1098 -IEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1156
Query: 142 NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG-KIAQLEGK 200
G + +I ++ KRE + + M E ++ + T +L + +A+L +
Sbjct: 1157 AGGATSAQI------EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ 1210
Query: 201 LVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSL 260
+ ++++ K + E ++ I++++ + V K K LE+ + D++ +K
Sbjct: 1211 IDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAK---GNLEKMCRALEDQLSEIKTKE 1267
Query: 261 EENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKL 320
EE + + DL + L+ E ++ +R + + L +++ KQ F + +E ++
Sbjct: 1268 EEQ----QRLINDLTAQRARLQTESGEY-SRQLDEKDTLVSQLSRGKQAFTQQIEELKRQ 1322
Query: 321 QQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQA 380
++E++ S L L SS H C E +E+ + EL++ + + + E A
Sbjct: 1323 LEEEIKAKSALAHA--LQSSRHD--CDLLREQYEEEQEAKAELQRAMSKANS-----EVA 1373
Query: 381 ERLVKQLEEEAKSRAEEL----KLLEEKLKGKEAELE----KSSAAHTQATLLLQEKYDS 432
+ K E +A R EEL K L ++L+ E +E K ++ L E D
Sbjct: 1374 QWRTKY-ETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDL 1432
Query: 433 MV----------------QSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNA 476
M+ ++ + + A+++ T +E+E + E+ SL + K
Sbjct: 1433 MIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAY 1492
Query: 477 EDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDF 536
E+ Q+ + N+ + + DL + A I E+ +++ +++L+ E+
Sbjct: 1493 EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE-KIKKQVEQEKSELQAALEEA 1551
Query: 537 RKQLEDEEGR-----------KAEKENTTAELTEEINKWR------------LLYEELYN 573
LE EEG+ K+E + AE EEI++ + L E+ +
Sbjct: 1552 EASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRS 1611
Query: 574 KTKPFQLQL----DAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQ-NLKQKIKHVVK 628
+ +L+ D E+E Q L + + A E L R++ A L Q +L ++
Sbjct: 1612 RNDAIRLKKKMEGDLNEMEIQ-LNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQED 1670
Query: 629 LKDENSQ-------LKSEVSKLRCQLAKKKQSETKLQEEL 661
LK++ + L++E+ +LR L + ++S ++EL
Sbjct: 1671 LKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQEL 1710
Score = 70.1 bits (170), Expect = 7e-12
Identities = 82/362 (22%), Positives = 163/362 (45%), Gaps = 42/362 (11%)
Query: 67 RKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLN-------AALREKTSLSANNA 119
R V+S +S + ++ R R + +E +L +ME +LN ALR + A
Sbjct: 1596 RIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILK 1655
Query: 120 TLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRE-TKMRGMMAKQEGMEM 178
+ L + R+ E LK + + + NL L E+ +LR E T+ +A+QE ++
Sbjct: 1656 DTQLHLDDALRSQEDLKEQLAMVERRANL--LQAEIEELRATLEQTERSRKIAEQELLDA 1713
Query: 179 KLQV------------TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEIS 226
+V T++ LE I+Q++G++ I +E ++ EK + I + +
Sbjct: 1714 SERVQLLHTQNTSLINTKKKLETD---ISQIQGEMEDIIQEA---RNAEEKAKKAITDAA 1767
Query: 227 CASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVIL----SKQVEDLNVKCQLLE 282
+++++K + A LE K + L+ L+E + KQ++ L + + LE
Sbjct: 1768 MMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELE 1827
Query: 283 KEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLH 342
E E RN E + L + +K+ +++R+ + + + +D L + K
Sbjct: 1828 GEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQ-- 1885
Query: 343 QKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLE 402
EE ++ N+ + ++ EL++ +++ + AE V +L KSR K++
Sbjct: 1886 ------AEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKL--RVKSREVHTKIIS 1937
Query: 403 EK 404
E+
Sbjct: 1938 EE 1939
Score = 60.8 bits (146), Expect = 4e-09
Identities = 95/460 (20%), Positives = 193/460 (41%), Gaps = 64/460 (13%)
Query: 55 NVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALRE-KTS 113
++D+ TL + ++ S + + E G + ++ ++ ++E+ ++ L AAL E + S
Sbjct: 1495 SLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEAS 1554
Query: 114 LSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQ 173
L + + +EL + + K +E + ++ MK + R
Sbjct: 1555 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEE-------IDQMKRNHIRIV--------- 1598
Query: 174 EGMEMKLQVTQRSLEESQGKIAQLEGKLVSIE----------KEKIDEKSETEKLLEYIE 223
E M+ L RS ++ ++EG L +E E + T+ +L+ +
Sbjct: 1599 ESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQ 1658
Query: 224 -EISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEE---NIVILSKQVEDLNVKCQ 279
+ A E K +A +E EI L+ +LE+ + I +++ D + + Q
Sbjct: 1659 LHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQ 1718
Query: 280 LLEKEKEDHVNRNREHNENLN---AEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKE 336
LL + +N ++ +++ EM+++ Q+ +++ +K + L++E++
Sbjct: 1719 LLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQD 1778
Query: 337 LSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKL---------QQKEEQAERLVKQL 387
S+ L E M K ++L+ LDE ++L Q+ E + L ++
Sbjct: 1779 TSAHL--------ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEV 1830
Query: 388 EEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESY 447
E E K E +K L K + K EL + + L LQ+ D + A+ +SY
Sbjct: 1831 ESEQKRNVEAVKGL-RKHERKVKELTYQTEEDRKNILRLQDLVDKL-------QAKVKSY 1882
Query: 448 KALTASEIEDLKLENSS----LQEKAAKAGKNAEDVQHQI 483
K A E E+ N S +Q + +A + A+ + Q+
Sbjct: 1883 KR-QAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQV 1921
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 117 bits (292), Expect = 5e-26
Identities = 133/551 (24%), Positives = 259/551 (47%), Gaps = 60/551 (10%)
Query: 156 MKLRNKRETKMRGMMAKQEGMEMKLQVTQ--RSLEESQGKIAQLEGKLVSIEKEKIDEKS 213
MKL K + ++ ++E MK + T+ +LE+S+ + +LE K+VS+ +EK D +
Sbjct: 830 MKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQL 889
Query: 214 ETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND----------EILSLKQSLEEN 263
+ + + + + DQ+ K K+ QLE +KE N+ E+ + K+ LE+
Sbjct: 890 QVQAEQDNLADAEERCDQLIKNKI---QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE 946
Query: 264 IVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK 323
L + ++DL + +EKEK N+ + NL EM L + +E++ LQ+
Sbjct: 947 CSELKRDIDDLELTLAKVEKEKHATENKVK----NLTEEMAGLDEIIAKLTKEKKALQEA 1002
Query: 324 ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 383
Q LQ E++ ++L + ++++ + E+E K +D L++ + + E
Sbjct: 1003 HQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMD----LERAKRKLEGD 1058
Query: 384 VKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLL---LQEKYDSMVQSLEDV 440
+K +E + + L+E+LK K+ EL +A L LQ+K + +E++
Sbjct: 1059 LKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEEL 1118
Query: 441 TAQFESYKALTASEIE----DLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRM 496
+ E+ + A ++E DL E + E+ +AG A V QI + E+ +M
Sbjct: 1119 EEELEAERTARA-KVEKLRSDLSRELEEISERLEEAG-GATSV--QIEMNKKREAEFQKM 1174
Query: 497 LLDLQ--------TKSALKETEIKEITVSFLQKITDLQ---NQLKQQEEDFRKQLEDEEG 545
DL+ T +AL++ + ++I +LQ +L++++ +F+ +L+D
Sbjct: 1175 RRDLEEATLQHEATAAALRKKHADSV-AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTS 1233
Query: 546 R-------KAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQAL---LNE 595
KA E L +++N+ R EE Q + E L L+E
Sbjct: 1234 NMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDE 1293
Query: 596 HGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKK-QSE 654
A QL + + +Y + L ++LK++++ VK K+ + + ++ C L +++ + E
Sbjct: 1294 KEALISQLTRGKLTYTQQL--EDLKRQLEEEVKAKNALAH-ALQSARHDCDLLREQYEEE 1350
Query: 655 TKLQEELNKVL 665
T+ + EL +VL
Sbjct: 1351 TEAKAELQRVL 1361
Score = 104 bits (260), Expect = 2e-22
Identities = 150/703 (21%), Positives = 293/703 (41%), Gaps = 86/703 (12%)
Query: 30 EVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRR 89
E + ++ +K + + E K++++ D + TL ++ ++E+K++ L +E D
Sbjct: 930 EEMNAELTAKKRKLEDECSELKRDID-DLELTLAKVEKEKHATENKVKNLTEEMAGLDEI 988
Query: 90 IQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQK--- 146
I L E + ++ AL + + TL K ++L + + L+ + +
Sbjct: 989 IAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDL 1048
Query: 147 ---------NLRILSLELMKLRN----------KRETKMRGMMAKQEGMEMKLQVTQRSL 187
+L++ +M L N K++ ++ + A+ E + Q+ L
Sbjct: 1049 ERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKL 1108
Query: 188 EESQGKIAQLEGKL-------VSIEKEKIDEKSETEKLLEYIEEISCASD-QVEKYKLDI 239
+E Q +I +LE +L +EK + D E E++ E +EE A+ Q+E K
Sbjct: 1109 KELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKRE 1168
Query: 240 AQLEENLKEKNDEIL-------SLKQSLEENIVILSKQVEDLNVKCQLLEKEKE------ 286
A+ ++ ++ + L +L++ +++ L +Q+++L Q LEKEK
Sbjct: 1169 AEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEL 1228
Query: 287 DHVNRNREHNENLNAEMQNLKQKFILEQQ--------------------EREKLQQKELQ 326
D V N E A ++ + + LE Q +R KLQ + +
Sbjct: 1229 DDVTSNMEQIIKAKANLEKMCRT--LEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGE 1286
Query: 327 IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 386
+ L +++ L S L + ++ +++ K EEE+K LQ + L +Q
Sbjct: 1287 LSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQ 1346
Query: 387 LEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFES 446
EEE +++AE ++L + K Q T L+E + Q L++ E+
Sbjct: 1347 YEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEA 1406
Query: 447 YKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSAL 506
A +S L+ LQ + + E A + + + ++L + + K
Sbjct: 1407 VNAKCSS----LEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEE 1462
Query: 507 KETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAE---LTEEINK 563
++E++ S ++ L +L + + + + LE E K E +N E LTE++
Sbjct: 1463 SQSELE----SSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGS 1518
Query: 564 WRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE-QLNKIRDSYAKLLGHQNLKQK 622
EL K QL+A ++E Q+ L E A+ E + KI + L +K +
Sbjct: 1519 SGKTIHELEKVRK----QLEAEKMELQSALEEAEASLEHEEGKILRAQ---LEFNQIKAE 1571
Query: 623 IKHVVKLKDEN-SQLKSEVSKLRCQLAKKKQSETKLQEELNKV 664
I+ + KDE Q K ++ L +ET+ + E +V
Sbjct: 1572 IERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRV 1614
Score = 88.2 bits (217), Expect = 2e-17
Identities = 125/622 (20%), Positives = 262/622 (42%), Gaps = 70/622 (11%)
Query: 42 QRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKME 101
QR ++ +E+K+ L A++++ +E + + + + ++ L+ E+E +
Sbjct: 1381 QRTEELEEAKKKL-----------AQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM 1429
Query: 102 ARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNK 161
+ + +L +K L E + E +S+ + QK R LS EL KL+N
Sbjct: 1430 VDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESS--QKEARSLSTELFKLKNA 1487
Query: 162 RETKMRGMMA-KQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLE 220
E + + K+E ++ +++ L E G + +L + K+ EK E + LE
Sbjct: 1488 YEESLEHLETFKRENKNLQEEISD--LTEQLGSSGKTIHELEKVRKQLEAEKMELQSALE 1545
Query: 221 YIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQL 280
E AS + E+ K+ AQLE N +K +E + K +
Sbjct: 1546 EAE----ASLEHEEGKILRAQLEFN---------QIKAEIERKLA----------EKDEE 1582
Query: 281 LEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSS 340
+E+ K +H+ +L+AE ++ + ++++ L + E+Q+ + E
Sbjct: 1583 MEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEA--- 1639
Query: 341 LHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 400
QK + ++K+ + ++ + D+L KE A +V++ ++ EEL+
Sbjct: 1640 --QKQVKSLQSLLKDTQIQLDDAVRANDDL-----KENIA--IVERRNNLLQAELEELRA 1690
Query: 401 LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKL 460
+ E+ + E+ ++ LL + S++ + + A + +E+E+
Sbjct: 1691 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQ----TEVEEAVQ 1746
Query: 461 ENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQ 520
E + +EKA KA +A + ++ + ++ RM +++ + + E L+
Sbjct: 1747 ECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALK 1806
Query: 521 KITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQL 580
+L+ + + +LE E+ R AE + I + EE Q
Sbjct: 1807 GGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQD 1866
Query: 581 QLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL-KSE 639
+D +++ +A + A+EQ N + +K++H + +E + + +S+
Sbjct: 1867 LVDKLQLKVKAYKRQAEEAEEQANTNLSKF----------RKVQHELDEAEERADIAESQ 1916
Query: 640 VSKLRCQLAKKKQSETK-LQEE 660
V+KLR AK + TK L EE
Sbjct: 1917 VNKLR---AKSRDIGTKGLNEE 1935
Score = 70.5 bits (171), Expect = 5e-12
Identities = 88/450 (19%), Positives = 199/450 (44%), Gaps = 53/450 (11%)
Query: 37 SFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETE 96
S + + FK++ ++ Q D L +S + + E + L E+ +++ E
Sbjct: 1491 SLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEAS 1550
Query: 97 LEKMEARLNAALREKTSLSANNATLEKQL------IELTRTNEL-----LKSKFSENGNQ 145
LE E ++ LR + + A +E++L +E + N L L++
Sbjct: 1551 LEHEEGKI---LRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRS 1607
Query: 146 KN--LRILS-----LELMKLRNKRETKMRGMMAKQ-EGMEMKLQVTQRSLEESQGKIAQL 197
+N LR+ L M+++ +M KQ + ++ L+ TQ L+++ L
Sbjct: 1608 RNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDL 1667
Query: 198 EGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLK 257
+ + +E+ ++E E+L +E+ + E+ ++ ++ + L +N +++ K
Sbjct: 1668 KENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQK 1727
Query: 258 QSLEENIVILSKQVEDLNVKCQLLEKEKE----------DHVNRNREHNENLNAEMQNLK 307
+ ++ ++ L +VE+ +C+ E++ + + + + ++ + +L +N++
Sbjct: 1728 KKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNME 1787
Query: 308 Q-----KFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQ---------KLCSFQEEMV 353
Q + L++ E+ L+ + Q+ L + +EL + L K E +
Sbjct: 1788 QTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI 1847
Query: 354 KEKNLFEEELKQTL----DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKE 409
KE EE ++ L D +DKLQ K + +R ++ EE+A + + + ++ +L E
Sbjct: 1848 KELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHEL--DE 1905
Query: 410 AELEKSSAAHTQATLLLQEKYDSMVQSLED 439
AE E++ A +Q L + D + L +
Sbjct: 1906 AE-ERADIAESQVNKLRAKSRDIGTKGLNE 1934
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 116 bits (291), Expect = 6e-26
Identities = 162/682 (23%), Positives = 318/682 (46%), Gaps = 102/682 (14%)
Query: 46 QQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLN 105
++ ES+Q+L+V+ + +++KIR L QE + ++ D + ELE+ME L
Sbjct: 241 KRTESRQHLSVE-----------LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELK 289
Query: 106 AALREKTSL--SANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRE 163
+E +L A +A + + ++ R + K ++ R+ +E K R +
Sbjct: 290 RLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEEL 349
Query: 164 TKMRGMMAKQEGM-EMKLQVTQR---SLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLL 219
+ ++ + + M E +L+ T+ L E + + QL+ KL +E E+ ++ + E+L+
Sbjct: 350 KEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELM 409
Query: 220 E---------------------YIEEISCASDQVEKYK---------------LDIAQLE 243
E +E+IS S+ E + L +
Sbjct: 410 EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMEN 469
Query: 244 ENLKEKNDEILSLKQSLEEN---IVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLN 300
++L + +E+ + S+E N I+ + K+ + L+ K ++LE E ++ ++ +NL+
Sbjct: 470 QSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQE-KQSLQNCQNLS 528
Query: 301 AEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELS---SSLHQKLCSFQEEMV---- 353
++ +K+K LE+ + E QI L Q+ + L+ SSL Q+ E V
Sbjct: 529 KDL--MKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIE 586
Query: 354 KEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELE 413
KE + E +K+T +L K++ ++ Q ++ ++ +E+ + RAEEL+ L+ KE EL
Sbjct: 587 KENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE-RAEELENELHHLE-KENELL 644
Query: 414 KSSAAHTQATL----LLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKA 469
+ + + T L+++ + + + +S+K LT ++E L+ ENS L E+
Sbjct: 645 QKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLT-FQLESLEKENSQLDEEN 703
Query: 470 AKAGKNAEDV--------QHQILATE-SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQ 520
+ +N E + Q Q+ E S +E ++ L+L K++ K+TE E++ L
Sbjct: 704 LELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLEL-LKASFKKTERLEVSYQGL- 761
Query: 521 KITDLQNQ-LKQQEEDFRKQLE--DEEGRKAEKENTTAELT-EEINKWRLLYEELYNKTK 576
D++NQ L++ E+ K+++ + E + E EN T + EE+ E+L + K
Sbjct: 762 ---DIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENK 818
Query: 577 PFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL 636
+ + E +K+ L E+ ++Q +I+D+ L N+K + L+ EN L
Sbjct: 819 SLEQETSQLEKDKKQLEKENKRLRQQA-EIKDT---TLEENNVK-----IGNLEKENKTL 869
Query: 637 KSEVS--KLRCQLAKKKQSETK 656
E+ K C K+ + E K
Sbjct: 870 SKEIGIYKESCVRLKELEKENK 891
Score = 112 bits (280), Expect = 1e-24
Identities = 148/673 (21%), Positives = 287/673 (42%), Gaps = 94/673 (13%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELE 98
+K +R ++ + +L + + L +K + KI L QE +R + L+ L+
Sbjct: 622 EKGERAEELENELHHLEKENEL-LQKKITNLKITCEKIEALEQENSELERENRKLKKTLD 680
Query: 99 KMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKS----------KFSENGNQKNL 148
+ L L SL N+ L+++ +EL R E LK + E ++K
Sbjct: 681 SFK-NLTFQLE---SLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQ 736
Query: 149 RILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEK 208
LEL+K K+ ++ +G++++ Q Q++LE S KI QLE +L +E
Sbjct: 737 LKKGLELLKASFKKTERLE---VSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM-- 791
Query: 209 IDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILS 268
E +K LE ++ S +Q+EK + Q L++ ++ + L + I
Sbjct: 792 --ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849
Query: 269 KQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFI----LEQQEREKLQQKE 324
+E+ NVK LEKE N+ L+ E+ K+ + LE++ +E +++
Sbjct: 850 TTLEENNVKIGNLEKE-----------NKTLSKEIGIYKESCVRLKELEKENKELVKRAT 898
Query: 325 LQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLV 384
+ I +L+ ++L S E +K + + +L++ EL+K+ +E
Sbjct: 899 IDIKTLVTLREDLVS-----------EKLKTQQM-NNDLEKLTHELEKIGLNKE------ 940
Query: 385 KQLEEEAKSRAEELKLLEEKLKG---KEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVT 441
+ L +E + KLLE KL+ K E+++ A +A L Y+ ++ +++
Sbjct: 941 RLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLR--QELK 998
Query: 442 AQFESYKALTASEIEDLKLENS-SLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDL 500
++Y+AL + E+ +++S + + K + +++ ++L + E R L
Sbjct: 999 TVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATL 1058
Query: 501 QTKSALKETEIKEI-----------------TVSFLQKITDLQNQ----------LKQQE 533
Q + +T++K++ TVS ++ T LQ Q L Q
Sbjct: 1059 QAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQS 1118
Query: 534 EDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALL 593
Q +++ EN + +E + LY+ L + +L + E ++L+
Sbjct: 1119 TSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLI 1178
Query: 594 NEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQS 653
++HG + + + L N Q +K +L+D LK E K+ L + K
Sbjct: 1179 SKHGTLKSAHKNLEVEHRDLEDRYN--QLLKQKGQLEDLEKMLKVEQEKM---LLENKNH 1233
Query: 654 ETKLQEELNKVLG 666
ET + E K+ G
Sbjct: 1234 ET-VAAEYKKLCG 1245
Score = 94.0 bits (232), Expect = 4e-19
Identities = 156/672 (23%), Positives = 284/672 (42%), Gaps = 84/672 (12%)
Query: 25 DVKTLEVLKGPVSFQ-KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQER 83
D + LE+ + S + S + Q + + L +K+ L +K+S K L
Sbjct: 700 DEENLELRRNVESLKCASMKMAQLQLENKELESEKEQ-LKKGLELLKASFKKTERLEVSY 758
Query: 84 GAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENG 143
D Q L+ LE ++ E L N TL+K L EL +++ L+ EN
Sbjct: 759 QGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKEN- 817
Query: 144 NQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVS 203
K+L + +L K +K++ + +Q+ ++ +LEE+ KI LE + +
Sbjct: 818 --KSLEQETSQLEK--DKKQLEKENKRLRQQA-----EIKDTTLEENNVKIGNLEKENKT 868
Query: 204 IEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQL--------EENLK--EKNDEI 253
+ KE K +L E +E + V++ +DI L E LK + N+++
Sbjct: 869 LSKEIGIYKESCVRLKELEKE---NKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL 925
Query: 254 LSLKQSLE------ENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQ-NL 306
L LE E ++ + +D K LLE + E + ++ E E A ++ L
Sbjct: 926 EKLTHELEKIGLNKERLLHDEQSTDDSRYK--LLESKLESTLKKSLEIKEEKIAALEARL 983
Query: 307 KQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQT 366
++ QQ R++L+ + ++L Q++ E +++ + E N +E E ++T
Sbjct: 984 EESTNYNQQLRQELKTVKKNYEALKQRQDE------ERMVQSSPPISGEDNKWERESQET 1037
Query: 367 LDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLL 426
EL K++ + + ER L+ E ++ +LK LE + +A++ A + T+ L
Sbjct: 1038 TRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI----LALQRQTVSL 1093
Query: 427 QEKYDSMV---QSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQ--- 480
QE+ ++ L+ + S ++ L ++ SSL+ + K ED++
Sbjct: 1094 QEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLY 1153
Query: 481 ------HQILAT--ESSNQEYVRMLLDLQT-KSALKETEIKEITVSFLQKITDLQNQL-- 529
H+ L E EY ++ T KSA K E++ + + D NQL
Sbjct: 1154 DSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEH------RDLEDRYNQLLK 1207
Query: 530 -KQQEEDFRKQLEDEEGR----KAEKENTTAE---LTEEINKWRLLYEELYNKTKPFQLQ 581
K Q ED K L+ E+ + E AE L E ++ Y +L +T+ Q
Sbjct: 1208 QKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTD 1267
Query: 582 -------LDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENS 634
L+ ++E+ L E +EQ ++ + KL L ++K L++EN
Sbjct: 1268 HKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKG--NLEEENR 1325
Query: 635 QLKSEVSKLRCQ 646
L ++ L Q
Sbjct: 1326 HLLDQIQTLMLQ 1337
Score = 73.6 bits (179), Expect = 6e-13
Identities = 133/637 (20%), Positives = 266/637 (41%), Gaps = 118/637 (18%)
Query: 123 KQLIELTRTNELL--KSKFSENGNQKNLRILSLEL---MKLRNKRE--TKMRGM-MAKQE 174
+QLI ++ N L+ K+ FSE G ++ ++L L L ++ + K E +++G+ +
Sbjct: 95 QQLIMMSLPNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKA 154
Query: 175 GMEMKLQVTQRSLEE------------SQGKIAQLEGKLVSIEKEKIDEKSE-TEKLLEY 221
+ +Q + E SQ I L + K IDE+ E +E ++E
Sbjct: 155 AVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIEL 214
Query: 222 IEEIS---------------CASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVI 266
EE C S +++ + L L + +I L+Q LEE
Sbjct: 215 SEERDGLHFLPHASSSAQSPCGSPGMKRTE-SRQHLSVELADAKAKIRRLRQELEEK--- 270
Query: 267 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQ 326
++Q+ D + + +E E + R ++ N NL ++ ++ + + + E + L++K ++
Sbjct: 271 -TEQLLDCKQELEQMEIE----LKRLQQENMNLLSDARSAR----MYRDELDALREKAVR 321
Query: 327 IDSLLQQEKELSSSLH---------QKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKE 377
+D L + LH ++L + +++ K + E++L+ T DKL + E
Sbjct: 322 VDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELE 381
Query: 378 EQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSL 437
++ +L +L + R + K +EE ++ + LE + +L L + + + ++
Sbjct: 382 KENLQLKAKLHDMEMERDMDRKKIEELME-ENMTLEMAQKQSMDESLHLGWELEQISRTS 440
Query: 438 EDVTAQFESY----KALTASEIEDLKLENSSLQEKAAKAGKNAEDVQ---HQILATESSN 490
E A +S LT+S + L++EN SL + + + V+ +IL E N
Sbjct: 441 ELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKEN 500
Query: 491 QEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEK 550
Q L K + E EI + S LQ +L L +++ K +E +
Sbjct: 501 QR-------LSKKVEILENEIVQEKQS-LQNCQNLSKDLMKEKAQLEKTIE------TLR 546
Query: 551 ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSY 610
EN+ ++ ++L +E + + ++ +A + + E+ NKI
Sbjct: 547 ENSERQI-------KILEQENEHLNQTVSSLRQRSQISAEARVKDI----EKENKIL--- 592
Query: 611 AKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHF 670
H+++K+ + K++ E Q+K E+ + +K + +L+ EL
Sbjct: 593 -----HESIKETSSKLSKIEFEKRQIKKELEHYK----EKGERAEELENEL--------- 634
Query: 671 DPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQES 707
HH KEN L+ + C + QE+
Sbjct: 635 ------HHLEKENELLQKKITNLKITCEKIEALEQEN 665
Score = 65.1 bits (157), Expect = 2e-10
Identities = 108/485 (22%), Positives = 207/485 (42%), Gaps = 73/485 (15%)
Query: 35 PVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLE 94
P+S + ++ ++ +E+ + L KD + E L E+ A +++ LE
Sbjct: 1022 PISGEDNKWERESQETTRELLKVKDRLIEV--------ERNNATLQAEKQALKTQLKQLE 1073
Query: 95 TELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLE 154
T+ ++A++ A R+ SL N TL+ Q +L N L S+ + NQ N ++L ++
Sbjct: 1074 TQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQ-NAQLL-IQ 1131
Query: 155 LMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDE--- 211
L N+ E+ ++ L+ SL + K+ L + S + I +
Sbjct: 1132 QSSLENENESVIKE--------REDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGT 1183
Query: 212 -KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQ 270
KS + L ++ +Q+ K K + LE+ LK + +++L L+ E + K+
Sbjct: 1184 LKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKML-LENKNHETVAAEYKK 1242
Query: 271 V----EDLNVKCQLLEKEKE----DH------VNRNREHNENLNAEMQNLKQKFILEQQE 316
+ + LN L KE E DH +N ++ L AE LK+++
Sbjct: 1243 LCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDIT 1302
Query: 317 REKLQ-QKEL--QIDSLLQQEKELSSSLHQKLC----SFQEEMVKEKNLFEEELKQTLDE 369
KL Q EL Q+ L++E Q L + E+ ++ K+LF E +Q +D+
Sbjct: 1303 STKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDK 1362
Query: 370 LDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEK 429
L++L++++E+ LEEK+ + + S + L K
Sbjct: 1363 LNELRRQKEK---------------------LEEKIMDQYKFYDPSPPRRRGNWITL--K 1399
Query: 430 YDSMVQSLEDVTAQFESYKALTASEIED----LKLENSSLQEKAAKAGKNAEDVQHQILA 485
+++S +D+ + + LT + + L+L + Q+ ++ + ED Q L
Sbjct: 1400 MRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLED--GQTLG 1457
Query: 486 TESSN 490
T+ S+
Sbjct: 1458 TKKSS 1462
Score = 42.4 bits (98), Expect = 0.002
Identities = 89/465 (19%), Positives = 192/465 (41%), Gaps = 41/465 (8%)
Query: 204 IEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEEN 263
+E +++++K + L + +S Q++ Y + Q + N I+ K E
Sbjct: 59 LESQRVNKKVNNDASLR-MHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIG-KNPFSEQ 116
Query: 264 IVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK 323
K++ L + C + ++KE+ + R + + + A + Q+ Q+ LQ
Sbjct: 117 GTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWM 176
Query: 324 ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 383
E + + Q++ E L + + + ++ E++ E + + +E D L +
Sbjct: 177 E--VTDMSQEDIE---PLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSA 231
Query: 384 VKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQ 443
R E + L +L +A++ + L+++ + + L D +
Sbjct: 232 QSPCGSPGMKRTESRQHLSVELADAKAKIRR-----------LRQELEEKTEQLLDCKQE 280
Query: 444 FESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQH------QILATESSNQEYVRML 497
E + E++ L+ EN +L A A +++ ++ ES Y L
Sbjct: 281 LEQMEI----ELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERL 336
Query: 498 LDLQTKSALKETEIKEITVSFLQKITDLQNQLK--QQEEDFRKQLEDEEGRKAEKENTTA 555
D++ A E E+KE L+ T L++QL+ + D +LE E + K +
Sbjct: 337 HDIEFYKARVE-ELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDM- 394
Query: 556 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNK---IRDSYAK 612
E+ ++++ ++ EEL + ++ E L G EQ+++ + ++ K
Sbjct: 395 EMERDMDRKKI--EELMEENMTLEMAQKQSMDESLHL----GWELEQISRTSELSEAPQK 448
Query: 613 LLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKL 657
LGH+ + ++KL+ EN L V +LR + + + +K+
Sbjct: 449 SLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI 493
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 116 bits (291), Expect = 6e-26
Identities = 162/682 (23%), Positives = 318/682 (46%), Gaps = 102/682 (14%)
Query: 46 QQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLN 105
++ ES+Q+L+V+ + +++KIR L QE + ++ D + ELE+ME L
Sbjct: 241 KRTESRQHLSVE-----------LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELK 289
Query: 106 AALREKTSL--SANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRE 163
+E +L A +A + + ++ R + K ++ R+ +E K R +
Sbjct: 290 RLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEEL 349
Query: 164 TKMRGMMAKQEGM-EMKLQVTQR---SLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLL 219
+ ++ + + M E +L+ T+ L E + + QL+ KL +E E+ ++ + E+L+
Sbjct: 350 KEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELM 409
Query: 220 E---------------------YIEEISCASDQVEKYK---------------LDIAQLE 243
E +E+IS S+ E + L +
Sbjct: 410 EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMEN 469
Query: 244 ENLKEKNDEILSLKQSLEEN---IVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLN 300
++L + +E+ + S+E N I+ + K+ + L+ K ++LE E ++ ++ +NL+
Sbjct: 470 QSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQE-KQSLQNCQNLS 528
Query: 301 AEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELS---SSLHQKLCSFQEEMV---- 353
++ +K+K LE+ + E QI L Q+ + L+ SSL Q+ E V
Sbjct: 529 KDL--MKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIE 586
Query: 354 KEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELE 413
KE + E +K+T +L K++ ++ Q ++ ++ +E+ + RAEEL+ L+ KE EL
Sbjct: 587 KENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE-RAEELENELHHLE-KENELL 644
Query: 414 KSSAAHTQATL----LLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKA 469
+ + + T L+++ + + + +S+K LT ++E L+ ENS L E+
Sbjct: 645 QKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLT-FQLESLEKENSQLDEEN 703
Query: 470 AKAGKNAEDV--------QHQILATE-SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQ 520
+ +N E + Q Q+ E S +E ++ L+L K++ K+TE E++ L
Sbjct: 704 LELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLEL-LKASFKKTERLEVSYQGL- 761
Query: 521 KITDLQNQ-LKQQEEDFRKQLE--DEEGRKAEKENTTAELT-EEINKWRLLYEELYNKTK 576
D++NQ L++ E+ K+++ + E + E EN T + EE+ E+L + K
Sbjct: 762 ---DIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENK 818
Query: 577 PFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL 636
+ + E +K+ L E+ ++Q +I+D+ L N+K + L+ EN L
Sbjct: 819 SLEQETSQLEKDKKQLEKENKRLRQQA-EIKDT---TLEENNVK-----IGNLEKENKTL 869
Query: 637 KSEVS--KLRCQLAKKKQSETK 656
E+ K C K+ + E K
Sbjct: 870 SKEIGIYKESCVRLKELEKENK 891
Score = 114 bits (284), Expect = 4e-25
Identities = 152/661 (22%), Positives = 287/661 (43%), Gaps = 71/661 (10%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELE 98
+K +R ++ + +L + + L +K + KI L QE +R + L+ L+
Sbjct: 622 EKGERAEELENELHHLEKENEL-LQKKITNLKITCEKIEALEQENSELERENRKLKKTLD 680
Query: 99 KMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKS----------KFSENGNQKNL 148
+ L L SL N+ L+++ +EL R E LK + E ++K
Sbjct: 681 SFK-NLTFQLE---SLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQ 736
Query: 149 RILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEK 208
LEL+K K+ ++ +G++++ Q Q++LE S KI QLE +L +E
Sbjct: 737 LKKGLELLKASFKKTERLE---VSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM-- 791
Query: 209 IDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILS 268
E +K LE ++ S +Q+EK + Q L++ ++ + L + I
Sbjct: 792 --ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849
Query: 269 KQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFI----LEQQEREKLQQKE 324
+E+ NVK LEKE N+ L+ E+ K+ + LE++ +E +++
Sbjct: 850 TTLEENNVKIGNLEKE-----------NKTLSKEIGIYKESCVRLKELEKENKELVKRAT 898
Query: 325 LQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLV 384
+ I +L+ ++L S +KL + ++M + EL++ ++L E+ +
Sbjct: 899 IDIKTLVTLREDLVS---EKLKT--QQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRY 953
Query: 385 KQLEEEAKSRAEE-LKLLEEKLKGKEAELEKSSAAHTQATLLL---QEKYDSMVQSLEDV 440
K LE + +S ++ L++ EEK+ EA LE+S+ + Q L ++ Y+++ Q +D
Sbjct: 954 KLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQR-QDE 1012
Query: 441 TAQFESYKALTASEIEDLKLENSSLQ--EKAAKAGKNAEDVQHQILATESSNQEYVRMLL 498
+S ++ ED K E S + + K +V+ ++ Q L
Sbjct: 1013 ERMVQSSPPISG---EDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLK 1069
Query: 499 DLQTKSALKETEIKEI---TVSFLQKITDLQNQ----------LKQQEEDFRKQLEDEEG 545
L+T++ + +I + TVS ++ T LQ Q L Q Q
Sbjct: 1070 QLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLI 1129
Query: 546 RKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNK 605
+++ EN + +E + LY+ L + +L + E ++L+++HG +
Sbjct: 1130 QQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN 1189
Query: 606 IRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVL 665
+ + L N Q +K +L+D LK E K+ L + K ET + E K+
Sbjct: 1190 LEVEHRDLEDRYN--QLLKQKGQLEDLEKMLKVEQEKM---LLENKNHET-VAAEYKKLC 1243
Query: 666 G 666
G
Sbjct: 1244 G 1244
Score = 94.7 bits (234), Expect = 3e-19
Identities = 155/669 (23%), Positives = 284/669 (42%), Gaps = 79/669 (11%)
Query: 25 DVKTLEVLKGPVSFQ-KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQER 83
D + LE+ + S + S + Q + + L +K+ L +K+S K L
Sbjct: 700 DEENLELRRNVESLKCASMKMAQLQLENKELESEKEQ-LKKGLELLKASFKKTERLEVSY 758
Query: 84 GAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENG 143
D Q L+ LE ++ E L N TL+K L EL +++ L+ EN
Sbjct: 759 QGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKEN- 817
Query: 144 NQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVS 203
K+L + +L K +K++ + +Q+ ++ +LEE+ KI LE + +
Sbjct: 818 --KSLEQETSQLEK--DKKQLEKENKRLRQQA-----EIKDTTLEENNVKIGNLEKENKT 868
Query: 204 IEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQL--------EENLK--EKNDEI 253
+ KE K +L E +E + V++ +DI L E LK + N+++
Sbjct: 869 LSKEIGIYKESCVRLKELEKE---NKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL 925
Query: 254 LSLKQSLEE---NIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQ-NLKQK 309
L LE+ N L + + + +LLE + E + ++ E E A ++ L++
Sbjct: 926 EKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEES 985
Query: 310 FILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDE 369
QQ R++L+ + ++L Q++ E +++ + E N +E E ++T E
Sbjct: 986 TNYNQQLRQELKTVKKNYEALKQRQDE------ERMVQSSPPISGEDNKWERESQETTRE 1039
Query: 370 LDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEK 429
L K++ + + ER L+ E ++ +LK LE + +A++ A + T+ LQE+
Sbjct: 1040 LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI----LALQRQTVSLQEQ 1095
Query: 430 YDSMV---QSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQ------ 480
++ L+ + S ++ L ++ SSL+ + K ED++
Sbjct: 1096 NTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSL 1155
Query: 481 ---HQILAT--ESSNQEYVRMLLDLQT-KSALKETEIKEITVSFLQKITDLQNQL---KQ 531
H+ L E EY ++ T KSA K E++ + + D NQL K
Sbjct: 1156 IKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEH------RDLEDRYNQLLKQKG 1209
Query: 532 QEEDFRKQLEDEEGR----KAEKENTTAE---LTEEINKWRLLYEELYNKTKPFQLQ--- 581
Q ED K L+ E+ + E AE L E ++ Y +L +T+ Q
Sbjct: 1210 QLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKN 1269
Query: 582 ----LDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLK 637
L+ ++E+ L E +EQ ++ + KL L ++K L++EN L
Sbjct: 1270 LKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKG--NLEEENRHLL 1327
Query: 638 SEVSKLRCQ 646
++ L Q
Sbjct: 1328 DQIQTLMLQ 1336
Score = 73.6 bits (179), Expect = 6e-13
Identities = 133/637 (20%), Positives = 266/637 (41%), Gaps = 118/637 (18%)
Query: 123 KQLIELTRTNELL--KSKFSENGNQKNLRILSLEL---MKLRNKRE--TKMRGM-MAKQE 174
+QLI ++ N L+ K+ FSE G ++ ++L L L ++ + K E +++G+ +
Sbjct: 95 QQLIMMSLPNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKA 154
Query: 175 GMEMKLQVTQRSLEE------------SQGKIAQLEGKLVSIEKEKIDEKSE-TEKLLEY 221
+ +Q + E SQ I L + K IDE+ E +E ++E
Sbjct: 155 AVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIEL 214
Query: 222 IEEIS---------------CASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVI 266
EE C S +++ + L L + +I L+Q LEE
Sbjct: 215 SEERDGLHFLPHASSSAQSPCGSPGMKRTE-SRQHLSVELADAKAKIRRLRQELEEK--- 270
Query: 267 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQ 326
++Q+ D + + +E E + R ++ N NL ++ ++ + + + E + L++K ++
Sbjct: 271 -TEQLLDCKQELEQMEIE----LKRLQQENMNLLSDARSAR----MYRDELDALREKAVR 321
Query: 327 IDSLLQQEKELSSSLH---------QKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKE 377
+D L + LH ++L + +++ K + E++L+ T DKL + E
Sbjct: 322 VDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELE 381
Query: 378 EQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSL 437
++ +L +L + R + K +EE ++ + LE + +L L + + + ++
Sbjct: 382 KENLQLKAKLHDMEMERDMDRKKIEELME-ENMTLEMAQKQSMDESLHLGWELEQISRTS 440
Query: 438 EDVTAQFESY----KALTASEIEDLKLENSSLQEKAAKAGKNAEDVQ---HQILATESSN 490
E A +S LT+S + L++EN SL + + + V+ +IL E N
Sbjct: 441 ELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKEN 500
Query: 491 QEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEK 550
Q L K + E EI + S LQ +L L +++ K +E +
Sbjct: 501 QR-------LSKKVEILENEIVQEKQS-LQNCQNLSKDLMKEKAQLEKTIE------TLR 546
Query: 551 ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSY 610
EN+ ++ ++L +E + + ++ +A + + E+ NKI
Sbjct: 547 ENSERQI-------KILEQENEHLNQTVSSLRQRSQISAEARVKDI----EKENKIL--- 592
Query: 611 AKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHF 670
H+++K+ + K++ E Q+K E+ + +K + +L+ EL
Sbjct: 593 -----HESIKETSSKLSKIEFEKRQIKKELEHYK----EKGERAEELENEL--------- 634
Query: 671 DPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQES 707
HH KEN L+ + C + QE+
Sbjct: 635 ------HHLEKENELLQKKITNLKITCEKIEALEQEN 665
Score = 68.2 bits (165), Expect = 3e-11
Identities = 121/561 (21%), Positives = 236/561 (42%), Gaps = 77/561 (13%)
Query: 35 PVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLE 94
P+S + ++ ++ +E+ + L KD + E L E+ A +++ LE
Sbjct: 1021 PISGEDNKWERESQETTRELLKVKDRLIEV--------ERNNATLQAEKQALKTQLKQLE 1072
Query: 95 TELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLE 154
T+ ++A++ A R+ SL N TL+ Q +L N L S+ + NQ N ++L ++
Sbjct: 1073 TQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQ-NAQLL-IQ 1130
Query: 155 LMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDE--- 211
L N+ E+ ++ L+ SL + K+ L + S + I +
Sbjct: 1131 QSSLENENESVIKE--------REDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGT 1182
Query: 212 -KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQ 270
KS + L ++ +Q+ K K + LE+ LK + +++L L+ E + K+
Sbjct: 1183 LKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKML-LENKNHETVAAEYKK 1241
Query: 271 V----EDLNVKCQLLEKEKE----DH------VNRNREHNENLNAEMQNLKQKFILEQQE 316
+ + LN L KE E DH +N ++ L AE LK+++
Sbjct: 1242 LCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDIT 1301
Query: 317 REKLQ-QKEL--QIDSLLQQEKELSSSLHQKLC----SFQEEMVKEKNLFEEELKQTLDE 369
KL Q EL Q+ L++E Q L + E+ ++ K+LF E +Q +D+
Sbjct: 1302 STKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDK 1361
Query: 370 LDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEK 429
L++L++++E+ LEEK+ + + S + L K
Sbjct: 1362 LNELRRQKEK---------------------LEEKIMDQYKFYDPSPPRRRGNWITL--K 1398
Query: 430 YDSMVQSLEDVTAQFESYKALTASEIED----LKLENSSLQEKAAKAGKNAEDVQHQILA 485
+++S +D+ + + LT + + L+L + Q+ ++ + ED Q L
Sbjct: 1399 MRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLED--GQTLG 1456
Query: 486 TESSNQEYVRMLLDLQT----KSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLE 541
T+ S+ ++ L L+ K +K + ++++ L + L Q E+ +
Sbjct: 1457 TKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVLAGQWTGSTENLEVPDD 1516
Query: 542 DEEGRKAEKENTTAELTEEIN 562
G++ ++ A T IN
Sbjct: 1517 ISTGKRRKELGAMAFSTTAIN 1537
Score = 42.4 bits (98), Expect = 0.002
Identities = 89/465 (19%), Positives = 192/465 (41%), Gaps = 41/465 (8%)
Query: 204 IEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEEN 263
+E +++++K + L + +S Q++ Y + Q + N I+ K E
Sbjct: 59 LESQRVNKKVNNDASLR-MHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIG-KNPFSEQ 116
Query: 264 IVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK 323
K++ L + C + ++KE+ + R + + + A + Q+ Q+ LQ
Sbjct: 117 GTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWM 176
Query: 324 ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 383
E + + Q++ E L + + + ++ E++ E + + +E D L +
Sbjct: 177 E--VTDMSQEDIE---PLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSA 231
Query: 384 VKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQ 443
R E + L +L +A++ + L+++ + + L D +
Sbjct: 232 QSPCGSPGMKRTESRQHLSVELADAKAKIRR-----------LRQELEEKTEQLLDCKQE 280
Query: 444 FESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQH------QILATESSNQEYVRML 497
E + E++ L+ EN +L A A +++ ++ ES Y L
Sbjct: 281 LEQMEI----ELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERL 336
Query: 498 LDLQTKSALKETEIKEITVSFLQKITDLQNQLK--QQEEDFRKQLEDEEGRKAEKENTTA 555
D++ A E E+KE L+ T L++QL+ + D +LE E + K +
Sbjct: 337 HDIEFYKARVE-ELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDM- 394
Query: 556 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNK---IRDSYAK 612
E+ ++++ ++ EEL + ++ E L G EQ+++ + ++ K
Sbjct: 395 EMERDMDRKKI--EELMEENMTLEMAQKQSMDESLHL----GWELEQISRTSELSEAPQK 448
Query: 613 LLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKL 657
LGH+ + ++KL+ EN L V +LR + + + +K+
Sbjct: 449 SLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI 493
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 116 bits (291), Expect = 6e-26
Identities = 156/652 (23%), Positives = 295/652 (45%), Gaps = 95/652 (14%)
Query: 68 KVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALRE-KTSLSANNATLEK-QL 125
+++ ESK++ + AQ + IQ+L+ EK+ +L ++E K + NNAT L
Sbjct: 126 ELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNL 185
Query: 126 IELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRG-----MMAKQEGMEMKL 180
++ T K+K E ++ ++ M L N E + + A+ +EM
Sbjct: 186 LKETCARSAEKTKKYEYEREETRQV----YMDLNNNIEKMITAFEELRVQAENSRLEMHF 241
Query: 181 QVTQ-----RSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQV--- 232
++ + + LE+ K + K VS+ +I EK K L ++ E S D+V
Sbjct: 242 KLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEES--RDKVNQL 299
Query: 233 -EKYKLDIAQLEENLKEKN---DEILSLKQSLEENIVILSKQVEDLNVK----CQLLEKE 284
EK KL L++++++++ E+ +K SL+ ++ EDL + CQL E E
Sbjct: 300 EEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTE-E 358
Query: 285 KE---DHVNRNREHNENLNAEMQNLKQKF-ILEQQEREKLQQKELQIDSLLQQEKELSSS 340
KE + N+ R + + E + L + E+++L++ E Q+ L + ++ SS
Sbjct: 359 KETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSE 418
Query: 341 LHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 400
L + ++ K + EELK+ L E + L + +Q E++ AEELK
Sbjct: 419 LEE-----MTKLTNNKEVELEELKKVLGEKETLLYENKQFEKI-----------AEELKG 462
Query: 401 LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLK- 459
E++L G EK E +D +Q L +T + Y + E++DLK
Sbjct: 463 TEQELIGLLQAREK-------------EVHDLEIQ-LTAITTSEQYY----SKEVKDLKT 504
Query: 460 -LENSSLQEKAAKAGKNAEDVQHQILATESSNQ--EYVRMLLDLQTKSALKETEIKEITV 516
LEN L+ + N ++++ L E+S+ E D+ +E +K+I
Sbjct: 505 ELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIE- 563
Query: 517 SFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTK 576
+ + T L+N+L+ E+ +++ ++ + + + E L +++ EEL + K
Sbjct: 564 NLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENK 623
Query: 577 PFQ-------LQLDAFEVEKQALLNEHGAAQEQLNKIRDSYA-----KLLGHQNLKQKIK 624
+ QL+ +E++ L E +A+++ +I D+Y K + +NL ++++
Sbjct: 624 ALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVE 683
Query: 625 HVVKLKDENSQLKSEVSKLRCQ---------LAKKKQSETKLQEELNKVLGI 667
+ DE +L+ E+ K RCQ + K K K+ EE + LG+
Sbjct: 684 KAKVIADEAVKLQKEIDK-RCQHKIAEMVALMEKHKHQYDKIIEERDSELGL 734
Score = 112 bits (281), Expect = 9e-25
Identities = 149/688 (21%), Positives = 293/688 (42%), Gaps = 78/688 (11%)
Query: 67 RKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANN--ATLEKQ 124
+++ E ++ +LL + ++ +++DL LE+ ++N L EKT L + N ++EKQ
Sbjct: 259 KEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVN-QLEEKTKLQSENLKQSIEKQ 317
Query: 125 LIELTRTNE-----LLKSKFSENGNQKNLRILSLELMKLRNKRETKM---RGMMAKQEGM 176
LT+ E L +S ++ +++L+I + + +L ++ET+M A +
Sbjct: 318 -HHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFV 376
Query: 177 EMKLQVTQRSLEE----SQGKIAQLEGKLVSIEKEKIDEKSETEKLLEY-------IEEI 225
+ + T SLEE Q ++ + E +L + E + SE E++ + +EE+
Sbjct: 377 VTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEEL 436
Query: 226 SCASDQVEKYKLDIAQLE---ENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLE 282
+ E + Q E E LK E++ L Q+ E+ + L Q+ + Q
Sbjct: 437 KKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYS 496
Query: 283 KEKEDHVNRNREHNENLNAEMQNLKQKFILEQQERE--------KLQQKELQIDSLLQQE 334
KE +D + E+ + N E+ + K LE +E +L+ ++ I++ +QE
Sbjct: 497 KEVKD-LKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQE 555
Query: 335 KELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD-KLQQKEEQAERLVKQLEEEAKS 393
+ + + + L + ++ E EELKQ DE+ KL + EE L KQ+E + K
Sbjct: 556 ERMLKQI-ENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNK- 613
Query: 394 RAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTAS 453
E+L+ + L+K A ++ + + K + + LE +F
Sbjct: 614 -------YIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQK 666
Query: 454 EIEDLKLENSSLQEKAAKAGKNAEDV-----------QHQI----LATESSNQEYVRMLL 498
EIED K+ +L E+ KA A++ QH+I E +Y +++
Sbjct: 667 EIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIE 726
Query: 499 DLQTKSAL---KETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA 555
+ ++ L KE E + S ++++L+ +L ++ + E++E K E + TA
Sbjct: 727 ERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTA 786
Query: 556 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG 615
L E+ +K + +T +LD+ V Q + + ++K + Y
Sbjct: 787 TLKEKKDK---KTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDYLWTSA 843
Query: 616 HQNLKQKIKHVVKLKD---------ENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLG 666
L + +K EN + E SK + ++A + + E + +
Sbjct: 844 KNTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESKKKRKMAFEFDINSDSSETTDLLSM 903
Query: 667 IKHFDPSKAFHHESK---ENFALKTPLK 691
+ + K + + + +KTP K
Sbjct: 904 VSEEETLKTLYRNNNPPASHLCVKTPKK 931
Score = 76.3 bits (186), Expect = 9e-14
Identities = 96/465 (20%), Positives = 205/465 (44%), Gaps = 69/465 (14%)
Query: 62 LPASARKVKSSESKIRVLLQERGAQDRRIQDL-------ETELEKMEARLNAALREKTSL 114
L ++++ +E ++++L E + ++++ E ELE+ L L EK +L
Sbjct: 391 LRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEE----LKKVLGEKETL 446
Query: 115 SANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKL--------RNKRETKM 166
N EK EL T + L +K + L ++L + + ++ K
Sbjct: 447 LYENKQFEKIAEELKGTEQELIGLLQ--AREKEVHDLEIQLTAITTSEQYYSKEVKDLKT 504
Query: 167 RGMMAKQEGMEMKLQVTQRSLEESQ--GKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE 224
K + E+ + SLE + + + + +L + +++ + K + E++L+ IE
Sbjct: 505 ELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIEN 564
Query: 225 ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE 284
+ Q+ ++ + E LK+K DE+ EEN L KQVE+ N + L++E
Sbjct: 565 LQETETQLRN---ELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQE 621
Query: 285 KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 344
+ + ++ LN K+ + EL+++S Q+ E++ +
Sbjct: 622 NKALKKKGTAESKQLNVY--------------EIKVNKLELELESAKQKFGEITDT---- 663
Query: 345 LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 404
+Q+E +++K + EE L L+E++K + ++A +L K++++ + + E+ L EK
Sbjct: 664 ---YQKE-IEDKKISEENL---LEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEK 716
Query: 405 LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS 464
K Q +++E+ DS + + + S +A E+ +LK E S
Sbjct: 717 HKH-------------QYDKIIEER-DSELGLYKSKEQEQSSLRASLEIELSNLKAELLS 762
Query: 465 LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKET 509
++++ + E ++ + N ++ D +T++ L ET
Sbjct: 763 VKKQLEIEREEKEKLKRE----AKENTATLKEKKDKKTQTFLLET 803
Score = 55.5 bits (132), Expect = 2e-07
Identities = 75/350 (21%), Positives = 151/350 (43%), Gaps = 16/350 (4%)
Query: 52 QNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALREK 111
+N D + R +K E+ Q R + ++L+ + ++++ +L+ +
Sbjct: 542 KNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC 601
Query: 112 TSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMA 171
+L K + EL + N+ LK K + Q N+ + + ++L + + G +
Sbjct: 602 NNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEIT 661
Query: 172 KQEGMEMK-LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASD 230
E++ ++++ +L E K + + V ++KE ID++ + K+ E + +
Sbjct: 662 DTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKE-IDKRCQ-HKIAEMVALMEKHKH 719
Query: 231 QVEKYKLDIAQLEENL---KEKNDEILSLKQSLEENIVILSKQVEDLNVKCQL-LEKEKE 286
Q +K I + + L K K E SL+ SLE I + + + E L+VK QL +E+E++
Sbjct: 720 QYDKI---IEERDSELGLYKSKEQEQSSLRASLE--IELSNLKAELLSVKKQLEIEREEK 774
Query: 287 DHVNRN-REHNENLNAEMQNLKQKFILEQQE-REKLQQKELQIDSLLQQEKELSSSLHQK 344
+ + R +E+ L + Q F+LE E KL K + ++ + + + +
Sbjct: 775 EKLKREAKENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKD 834
Query: 345 LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSR 394
+ KN L + + K +Q E L +EE K R
Sbjct: 835 KRDYL--WTSAKNTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESKKKR 882
Score = 32.3 bits (72), Expect = 1.6
Identities = 32/172 (18%), Positives = 79/172 (45%), Gaps = 11/172 (6%)
Query: 499 DLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELT 558
D + LK+++++ + ++ + ++L ++ E +K E +KE+ E
Sbjct: 84 DCHYQEGLKDSDLENS-----EGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENR 138
Query: 559 EEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYA----KLL 614
+ I R +EL + L+L+ E + L+ E+ A + N ++++ A K
Sbjct: 139 KIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTK 198
Query: 615 GHQNLKQKIKHV-VKLKDENSQLKSEVSKLRCQLAKKK-QSETKLQEELNKV 664
++ +++ + V + L + ++ + +LR Q + + KL+E+ K+
Sbjct: 199 KYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKI 250
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 116 bits (290), Expect = 8e-26
Identities = 150/704 (21%), Positives = 301/704 (42%), Gaps = 117/704 (16%)
Query: 68 KVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLI- 126
+V+ E + + L E+ + IQ+LE +LE+ E+ EK + A LE++ I
Sbjct: 923 RVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQII 982
Query: 127 ------ELTRTNELLKSKFSE-NGNQKNLRILSLELMKLRNKRE---TKMRGMMAKQEGM 176
+L + +LL+ + +E N S L KL+NK E T + + ++E
Sbjct: 983 LEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQ 1042
Query: 177 EMKLQVTQRSLE-----------ESQGKIAQLEGKLVSIEKE------KIDE-------- 211
+L+ T+R LE E Q +IA+L+ +L E+E +++E
Sbjct: 1043 RQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMA 1102
Query: 212 -------KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLK----------------- 247
+S+ +L E +E + ++ EK K D+ + E LK
Sbjct: 1103 LKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELR 1162
Query: 248 -EKNDEILSLKQSLEENIVILSKQVEDLNVK-------------------------CQLL 281
++ E+ LK++LEE Q++++ K Q L
Sbjct: 1163 SKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTL 1222
Query: 282 EKEKEDHVNR---------NREH-NENLNAEMQNLKQKFILEQQEREKLQQK--ELQID- 328
E E+ + N + EH + + A++Q L+ KF ++ R +L K +LQ++
Sbjct: 1223 ENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVEL 1282
Query: 329 ----SLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLV 384
LL Q SS L + + + ++ + L +EE +Q L KL+Q E++
Sbjct: 1283 DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFR 1342
Query: 385 KQLEEEAKSR---AEELKLLEEKLKGKEAELEKSSAAHTQATLL---LQEKYDSMVQSLE 438
+QLEEE +++ +++ L ++ + ++E S A + LQ+ + + Q E
Sbjct: 1343 EQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHE 1402
Query: 439 DVTAQF---ESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR 495
+ A + E K E++DL ++ ++ A K + + ++ + +Y
Sbjct: 1403 EKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAE 1462
Query: 496 MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA 555
+ ++ KET+ + + L++ + + +L++ + FR ++ED K + +
Sbjct: 1463 ERDRAEAEAREKETKALSLARA-LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVH 1521
Query: 556 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG 615
EL + EE+ + + + +L A E K L A + Q RD +
Sbjct: 1522 ELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE--RDLQGR--D 1577
Query: 616 HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 659
Q+ ++K + V ++++ ++L+ E + +A +K+ E L++
Sbjct: 1578 EQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKD 1621
Score = 115 bits (287), Expect = 2e-25
Identities = 134/669 (20%), Positives = 301/669 (44%), Gaps = 64/669 (9%)
Query: 41 SQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKM 100
+++ +Q K K NL K T + ++++VLLQ +G + + + +E +L+++
Sbjct: 1202 AEQLEQTKRVKANLEKAKQTL----ENERGELANEVKVLLQGKGDSEHKRKKVEAQLQEL 1257
Query: 101 EARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGN-QKNLRILSLELM--- 156
+ + N R +T L+ L+ +EL LL S++ K+ L +L
Sbjct: 1258 QVKFNEGERVRTELADKVTKLQ---VELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQ 1314
Query: 157 KLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETE 216
+L + + + K + +E + + LEE + LE ++ ++ + D K + E
Sbjct: 1315 ELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKME 1374
Query: 217 KLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNV 276
+ + C + E+ K + + E L ++++E ++ LE+ L ++++DL V
Sbjct: 1375 ------DSVGCL-ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLV 1427
Query: 277 KCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQERE----KLQQKELQIDSLLQ 332
+++ ++ + ++ + L AE + + K+ E+ E + + K L + L+
Sbjct: 1428 DLDH-QRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALE 1486
Query: 333 QEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDK----LQQKEEQAERLVKQLE 388
+ E + L + F+ EM ++ ++++ +++ EL+K L+Q+ E+ + +++LE
Sbjct: 1487 EAMEQKAELERLNKQFRTEM-EDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELE 1545
Query: 389 EEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFE--- 445
+E ++ + LE L+ +A+ E+ + + +EK +V+ + ++ A+ E
Sbjct: 1546 DELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQS---EEKKKQLVRQVREMEAELEDER 1602
Query: 446 SYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLD------ 499
+++ + + L+++ L+ A KN ++ Q+ ++ ++ +R L D
Sbjct: 1603 KQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASRE 1662
Query: 500 ---LQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEK------ 550
Q K K+ + E + LQ+ + K+Q + R +L DE + K
Sbjct: 1663 EILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALE 1722
Query: 551 -----ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVE-----KQALLNEHGAAQ 600
E A+L EE+ + + E + ++ K LQ+D + A NE+ Q
Sbjct: 1723 EKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQ 1782
Query: 601 -EQLNK-IRDSYAKLLGHQNLKQKIKHV---VKLKDENSQLKSEVSKLRCQLAKKKQSET 655
E+ NK ++ ++ G K K K+ QL +E + + + +++E
Sbjct: 1783 LERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEK 1842
Query: 656 KLQEELNKV 664
KL++ L +V
Sbjct: 1843 KLKDVLLQV 1851
Score = 101 bits (252), Expect = 2e-21
Identities = 147/648 (22%), Positives = 275/648 (42%), Gaps = 101/648 (15%)
Query: 40 KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEK 99
+SQ ++ + ++ L + T L A A ++++ + + L+E DLE +E+
Sbjct: 875 QSQLMAEKLQLQEQLQAE--TELCAEAEELRARLTAKKQELEEI------CHDLEARVEE 926
Query: 100 MEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLR 159
E R EK + N LE+QL E E+ QK L+L K+
Sbjct: 927 EEERCQHLQAEKKKMQQNIQELEEQLEE------------EESARQK------LQLEKVT 968
Query: 160 NKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLL 219
+ + K KL+ Q LE+ K+A+ E KL+ +++I E T L
Sbjct: 969 TEAKLK-------------KLEEEQIILEDQNCKLAK-EKKLL---EDRIAE--FTTNLT 1009
Query: 220 EYIEEISCASDQVEKYKLDIAQLEENLK---EKNDEILSLKQSLEENIVILSKQVEDL-- 274
E E+ + K++ I LEE L+ ++ E+ ++ LE + LS Q+ +L
Sbjct: 1010 EEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQA 1069
Query: 275 ---NVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLL 331
+K QL +KE+E L A + ++++ + +K+++ E QI S L
Sbjct: 1070 QIAELKMQLAKKEEE------------LQAALARVEEEAAQKNMALKKIRELESQI-SEL 1116
Query: 332 QQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDEL---DKLQQKEEQAERLVKQLE 388
Q++ E + K + ++ +E + EL+ TLD +L+ K EQ ++K
Sbjct: 1117 QEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILK--- 1173
Query: 389 EEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYK 448
K LEE+ K EA++++ H+QA E+ ++ + V A E K
Sbjct: 1174 ----------KTLEEEAKTHEAQIQEMRQKHSQAV----EELAEQLEQTKRVKANLEKAK 1219
Query: 449 ALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKE 508
+E +L E L + + + V+ Q+ + E R+ +L K +
Sbjct: 1220 QTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQ 1279
Query: 509 TEIKEITVSFLQ------KITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEIN 562
E+ +T Q K+T + L+ Q +D ++ L++E +K ++ +E N
Sbjct: 1280 VELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKN 1339
Query: 563 KWRLLYEELYNKTKPFQLQLDAFEVE----KQALLNEHG---AAQEQLNKIRDSYAKLLG 615
+R EE + Q+ + K+ + + G A+E K++ L
Sbjct: 1340 SFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGL-- 1397
Query: 616 HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNK 663
Q ++K+ KL+ ++L+ E+ L L ++QS L+++ K
Sbjct: 1398 SQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKK 1445
Score = 95.5 bits (236), Expect = 1e-19
Identities = 109/547 (19%), Positives = 245/547 (44%), Gaps = 49/547 (8%)
Query: 180 LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDI 239
LQV+++ EE K E +LV + ++++ ++ ++ ++ Q+++
Sbjct: 838 LQVSRQE-EEMMAK----EEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE 892
Query: 240 AQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENL 299
+L +E + + KQ LEE L +VE+ +CQ L+ EK+ +
Sbjct: 893 TELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKK-----------KM 941
Query: 300 NAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLF 359
+Q L+++ E+ R+KLQ +++ ++ L++ +E L + C ++ KEK L
Sbjct: 942 QQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNC----KLAKEKKLL 997
Query: 360 EEELKQTLDELDKLQQK-------EEQAERLVKQLEEEAK---SRAEELKLLEEKLKGKE 409
E+ + + L + ++K + + E ++ LEE + + +EL+ KL+G
Sbjct: 998 EDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057
Query: 410 AELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFE---SYKALTASEIEDLKLENSSLQ 466
+L A L+ + + L+ A+ E + K + +I +L+ + S LQ
Sbjct: 1058 TDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQ 1117
Query: 467 E--KAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 524
E ++ +A +N + Q + L E E ++ L+ S + E++ Q++
Sbjct: 1118 EDLESERASRNKAEKQKRDLGEE---LEALKTELEDTLDSTAAQQELRS---KREQEVNI 1171
Query: 525 LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA 584
L+ L+++ + Q+++ + + EL E++ + + + L + + +
Sbjct: 1172 LKKTLEEEAKTHEAQIQE---MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGE 1228
Query: 585 FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR 644
E + LL G ++ + K+ +L N ++++ +L D+ ++L+ E+ +
Sbjct: 1229 LANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVR--TELADKVTKLQVELDNVT 1286
Query: 645 CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLK--EGNTNCYRAPM 702
L++ +KL ++ + L + D + E+++ +L T LK E N +R +
Sbjct: 1287 GLLSQSDSKSSKLTKDFS-ALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQL 1345
Query: 703 ECQESWK 709
E +E K
Sbjct: 1346 EEEEEAK 1352
Score = 92.0 bits (227), Expect = 2e-18
Identities = 122/546 (22%), Positives = 251/546 (45%), Gaps = 86/546 (15%)
Query: 169 MMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEK--SETEKLLEYIE--- 223
MMAK+E + +K++ Q + E ++ L+ +L++ EK ++ E+ +ETE E E
Sbjct: 847 MMAKEEEL-VKVREKQLAAENRLTEMETLQSQLMA-EKLQLQEQLQAETELCAEAEELRA 904
Query: 224 EISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK 283
++ ++E+ D+ E +E+ + + K+ +++NI L +Q+E+ Q L+
Sbjct: 905 RLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQL 964
Query: 284 EK-EDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSL- 341
EK + E + E QN K +E++ L+ + + + L +E+E S SL
Sbjct: 965 EKVTTEAKLKKLEEEQIILEDQNCKL-----AKEKKLLEDRIAEFTTNLTEEEEKSKSLA 1019
Query: 342 -----HQKLCSFQEEMVKEKNLFEEELKQTLDELD----------------------KLQ 374
H+ + + EE ++ + +EL++T +L+ +L
Sbjct: 1020 KLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLA 1079
Query: 375 QKEEQAERLVKQLEEEAKSR---AEELKLLEEKLKGKEAELEKSSAAHTQATLL---LQE 428
+KEE+ + + ++EEEA + ++++ LE ++ + +LE A+ +A L E
Sbjct: 1080 KKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGE 1139
Query: 429 KYDSMVQSLEDV---TAQFESYKALTASEI--------EDLKLENSSLQEKAAKAGKNAE 477
+ +++ LED TA + ++ E+ E+ K + +QE K + E
Sbjct: 1140 ELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVE 1199
Query: 478 DVQHQILATE--SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEED 535
++ Q+ T+ +N E + L+ + E ++ LQ D +++ K+ E
Sbjct: 1200 ELAEQLEQTKRVKANLEKAKQTLENERGELANEVKV------LLQGKGDSEHKRKKVE-- 1251
Query: 536 FRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNE 595
QL++ + + E E EL +++ K L EL N T L + + L +
Sbjct: 1252 --AQLQELQVKFNEGERVRTELADKVTK---LQVELDNVTG----LLSQSDSKSSKLTKD 1302
Query: 596 HGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSET 655
A + QL ++ LL +N +QK+ KLK Q++ E + R QL ++++++
Sbjct: 1303 FSALESQLQDTQE----LLQEEN-RQKLSLSTKLK----QVEDEKNSFREQLEEEEEAKH 1353
Query: 656 KLQEEL 661
L++++
Sbjct: 1354 NLEKQI 1359
Score = 65.9 bits (159), Expect = 1e-10
Identities = 84/398 (21%), Positives = 185/398 (46%), Gaps = 57/398 (14%)
Query: 29 LEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDR 88
L+ +K R +Q +E K+ L R+V+ E+++ ++R
Sbjct: 1562 LQAMKAQFERDLQGRDEQSEEKKKQL-----------VRQVREMEAELEDERKQRSMAVA 1610
Query: 89 RIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSE-----NG 143
+ LE +L+ +EA +++A + + L+ Q+ + R + ++ E
Sbjct: 1611 ARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKE 1670
Query: 144 NQKNLRILSLELMKLRNKRETKMRGM-MAKQEGMEMKLQVTQRS------LEESQGKIAQ 196
N+K L+ + E+++L+ + R A+QE E+ ++ S LEE + +
Sbjct: 1671 NEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKR----R 1726
Query: 197 LEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSL 256
LE ++ +E+E +E+ TE + + +++ A+ Q+++ D+ LE + +KN+ +
Sbjct: 1727 LEARIAQLEEELEEEQGNTELINDRLKK---ANLQIDQINTDL-NLERSHAQKNE---NA 1779
Query: 257 KQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQE 316
+Q LE +Q ++L VK Q +E + ++ + L A++ L+++ E +E
Sbjct: 1780 RQQLE-------RQNKELKVKLQEMEGTVK---SKYKASITALEAKIAQLEEQLDNETKE 1829
Query: 317 RE------KLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDEL 370
R+ + +K+L+ D LLQ + E ++ K + + + ++LK+ L+E
Sbjct: 1830 RQAACKQVRRTEKKLK-DVLLQVDDERRNAEQYK------DQADKASTRLKQLKRQLEEA 1882
Query: 371 DKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK 408
++ Q+ + R +++ E+A A+ + LK K
Sbjct: 1883 EEEAQRANASRRKLQRELEDATETADAMNREVSSLKNK 1920
Score = 63.5 bits (153), Expect = 6e-10
Identities = 108/589 (18%), Positives = 242/589 (41%), Gaps = 81/589 (13%)
Query: 9 KRFNDPSGCAPSPGAYDVKTLEVLKGPVSF--QKSQRFKQQKESKQNLNVDKDTTLP--- 63
K+ D GC + K + L+G +K + + +++K L + D L
Sbjct: 1371 KKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLD 1430
Query: 64 ---ASARKVKSSESKIRVLL-----------QERGAQDRRIQDLETELEKMEARLNAALR 109
SA ++ + K LL +ER + ++ ET+ + L A+
Sbjct: 1431 HQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAME 1490
Query: 110 EKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGM 169
+K L N ++ +L + + + E +K+ R L ++ +++ + E +
Sbjct: 1491 QKAELERLNKQFRTEMEDLMSSKDDVGKSVHEL--EKSKRALEQQVEEMKTQLEELEDEL 1548
Query: 170 MAKQEG---MEMKLQVTQRSLEES-QGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI 225
A ++ +E+ LQ + E QG+ Q E K + ++ + ++E E + ++
Sbjct: 1549 QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELE---DERKQR 1605
Query: 226 SCASDQVEKYKLDIAQLEENLKEKN---DEILSLKQSLEENIVILSKQVEDLNV-KCQLL 281
S A +K ++D+ LE ++ N DE + + L+ + ++++D + ++L
Sbjct: 1606 SMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEIL 1665
Query: 282 EKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSL 341
+ KE N + +++ AEM L+++ ++ + + QQ+ ++ E+++S
Sbjct: 1666 AQAKE-----NEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELAD------EIANSS 1714
Query: 342 HQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLL 401
+ + +E K E + Q +EL++ Q E +K+ + +L L
Sbjct: 1715 GKGALALEE-----KRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLE 1769
Query: 402 EEKLKGKEAELEKSSAAHTQATLLLQE-------KYDSMVQSLEDVTAQFESYKALTASE 454
+ E ++ + + + LQE KY + + +LE AQ E +
Sbjct: 1770 RSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLE-------EQ 1822
Query: 455 IEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEI 514
+++ E + ++ + K +DV Q+ + ++Y K+ K
Sbjct: 1823 LDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQY-------------KDQADKAS 1869
Query: 515 TVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK 563
T ++ L+ QL++ EE+ ++ + E E+ T E + +N+
Sbjct: 1870 T-----RLKQLKRQLEEAEEEAQRANASRRKLQRELEDAT-ETADAMNR 1912
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 116 bits (290), Expect = 8e-26
Identities = 163/696 (23%), Positives = 310/696 (44%), Gaps = 99/696 (14%)
Query: 37 SFQKS-QRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLET 95
S QK+ + ++Q ++ L + + S K+ KI L E G Q R ++ +
Sbjct: 427 SLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKL----DKIMKELDEEGNQRRNLESTVS 482
Query: 96 ELEK----MEARLNAALRE-------KTSLSANNATLEKQLIEL---TRTNELLKSKFSE 141
++EK ++ R+N R+ + ++ +TL+ QL +L ++ ++L K S+
Sbjct: 483 QIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQ 542
Query: 142 NGNQKN-----LRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQ 196
Q LR S ++LR K T+M +++ E + +LQ R LE S+ + +
Sbjct: 543 LQKQLEEANDLLRTESDTAVRLR-KSHTEMSKSISQLESLNRELQERNRILENSKSQTDK 601
Query: 197 LEGKLVSI-EKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 255
+L +I E E+ D ++E + + I+ ++V+ K ++ ++E KE D +L+
Sbjct: 602 DYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQD-MLN 660
Query: 256 LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQ------- 308
+ + N+ I DLN K + L++ E VN ++ L + Q++++
Sbjct: 661 HSEKEKNNLEI------DLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMC 714
Query: 309 ----KFILEQQEREKLQQKELQID---SLLQQEKELSSSLHQKLCSFQEEMVKE-KNL-- 358
K E++ REK + + +QI+ S+L + + S + L +E M E KNL
Sbjct: 715 EMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTL 774
Query: 359 -----------FEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKG 407
+ ELK E D L+ E+Q ++ + L E + EL L ++ +G
Sbjct: 775 QLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRG 834
Query: 408 KEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQE 467
E ++ + +A Y + V+ L++ + E +I++L+ E +L
Sbjct: 835 NEGQM-RELQDQLEAEQYFSTLYKTQVKELKE---EIEEKNRENLKKIQELQNEKETLAT 890
Query: 468 KAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEI--KEITVSFLQKIT-- 523
+ A AE Q LA ++Y + + + ++ EI K+ TVS L++
Sbjct: 891 QLDLAETKAESEQ---LARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSM 947
Query: 524 ---DLQNQLKQQEEDFRKQLEDEEGRKAEKE----NTTAELTEEINKWRLLYEELYNKTK 576
D++ ++ EE K + EE K EKE N A + IN R L + NK
Sbjct: 948 LTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLA 1007
Query: 577 PFQLQLDAFEVEKQAL--------LNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVK 628
+ D F+++++ E+ Q +LN+ R+ + +++ +KH +
Sbjct: 1008 EIMNRKD-FKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMV--------VKHQKE 1058
Query: 629 LKDENSQLKSEV---SKLRCQLAKKKQSETKLQEEL 661
L D +QL E ++L+ QLA K+ +L+ +L
Sbjct: 1059 LNDMQAQLVEECAHRNELQMQLASKESDIEQLRAKL 1094
Score = 57.0 bits (136), Expect = 6e-08
Identities = 75/340 (22%), Positives = 153/340 (45%), Gaps = 42/340 (12%)
Query: 347 SFQEEMVKEKNLFEEELKQTLDELDKLQQK----EEQAERLVKQLEEEAKSRAEELKLLE 402
S QE + K EE+L + D+++QK + ++++K+L+EE R
Sbjct: 423 SLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQR-------- 474
Query: 403 EKLKGKEAELEKSSAAHTQATLLLQEK---YDSMVQSLEDVTAQFESYKALTASEIEDLK 459
L+ +++EK +LLQ + Y + + E+ + ++EDLK
Sbjct: 475 RNLESTVSQIEKEK-------MLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLK 527
Query: 460 --LENSSL-QEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITV 516
+NS L EK ++ K E+ + +L TES +R +KS ++++ +
Sbjct: 528 KVSQNSQLANEKLSQLQKQLEEA-NDLLRTESDTAVRLRKSHTEMSKSI---SQLESLNR 583
Query: 517 SFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTK 576
++ L+N Q ++D+ + E + ++ + +E I + L + K
Sbjct: 584 ELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHD----SEMIGDLQARITSLQEEVK 639
Query: 577 PFQLQLDAFEVEK---QALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKI-KHVV---KL 629
+ L+ E E+ Q +LN H ++ +I +Y Q L+Q++ +H V +L
Sbjct: 640 HLKHNLEKVEGERKEAQDMLN-HSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARL 698
Query: 630 KDENSQLKSEVSKLRCQLAKKKQSETKLQEEL-NKVLGIK 668
D++ ++ S C++ KK + E + +E+ N+V+ I+
Sbjct: 699 TDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIE 738
Score = 49.3 bits (116), Expect = 1e-05
Identities = 56/292 (19%), Positives = 133/292 (45%), Gaps = 11/292 (3%)
Query: 25 DVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPAS--ARKVKSSESKIRVLLQE 82
++ TL K + F+ +Q KQ + ++ + +D + K+ +++ ++E
Sbjct: 810 EINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEE 869
Query: 83 RGAQD-RRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSE 141
+ ++ ++IQ+L+ E E + +L+ A + S LE+Q ELT+ ++ S+ +
Sbjct: 870 KNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQ 929
Query: 142 NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKL 201
K+ + LE ++ + + ++E E+ ++ + E K ++
Sbjct: 930 EITDKDHTVSRLEEANSMLTKDIE----ILRRENEELTEKMKKAEEEYKLEKEEEISNLK 985
Query: 202 VSIEKEKIDEKSETEKLLEYIEEISCASD-QVEKYKLDIAQLEENLKEKNDEILSLKQSL 260
+ EK E++ + + + EI D ++++ K + L + KE L L Q
Sbjct: 986 AAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQER 1045
Query: 261 EE-NIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFI 311
E+ N +++ Q E +++ QL+E+ H N + + ++++ L+ K +
Sbjct: 1046 EKFNQMVVKHQKELNDMQAQLVEECA--HRNELQMQLASKESDIEQLRAKLL 1095
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 116 bits (290), Expect = 8e-26
Identities = 137/564 (24%), Positives = 266/564 (47%), Gaps = 86/564 (15%)
Query: 156 MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 213
MKL K + ++ ++E MK Q + L +S+ K +LE K+V++ KEK D +
Sbjct: 836 MKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL 895
Query: 214 ETEKLLEYIEEISCASDQVEKYKL-------DIAQLEENLKEKNDEILSLKQSLEENIVI 266
+ + E + + DQ+ K K+ ++ + E+ +E N E+ + K+ LE+
Sbjct: 896 QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955
Query: 267 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK--- 323
L K ++DL + +EKEK H N+ +NL EM L + +E++ LQ+
Sbjct: 956 LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1011
Query: 324 ----------------------ELQIDSL---LQQEKELSSSLHQK-------LCSFQEE 351
E Q+D L L+QEK+L L + L QE
Sbjct: 1012 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071
Query: 352 MV---KEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK 408
++ EK +E+LK+ E+ LQ K E + L QL+++ K ++ LEE+++ +
Sbjct: 1072 IMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAE 1131
Query: 409 EAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLK--LENSSLQ 466
A K+ + + L+E + + ++ +AQ E K A E + ++ LE ++LQ
Sbjct: 1132 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA-EFQKMRRDLEEATLQ 1190
Query: 467 EKAAKA---GKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKIT 523
+A A K+A+ V L + N + V+ L+ + KS +K EI ++ S ++ ++
Sbjct: 1191 HEATAATLRKKHADSVAE--LGEQIDNLQRVKQKLE-KEKSEMK-MEIDDL-ASNVETVS 1245
Query: 524 DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLD 583
+ L++ QL + + ++ E++ +LT + + L ++ F QLD
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGR-------LQTESGEFSRQLD 1298
Query: 584 AFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL----KSE 639
EK+AL++ QL++ + ++ + + + LK++++ +K K+ + + +
Sbjct: 1299 ----EKEALVS-------QLSRGKQAFTQQI--EELKRQLEEEIKAKNALAHALQSSRHD 1345
Query: 640 VSKLRCQLAKKKQSETKLQEELNK 663
LR Q ++++S+ +LQ L+K
Sbjct: 1346 CDLLREQYEEEQESKAELQRALSK 1369
Score = 107 bits (266), Expect = 5e-23
Identities = 139/673 (20%), Positives = 290/673 (43%), Gaps = 72/673 (10%)
Query: 40 KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEK 99
K + ++ E ++ +N + L A RK++ S+++ + I DLE L K
Sbjct: 924 KIKEVTERAEDEEEINAE----LTAKKRKLEDECSELK----------KDIDDLELTLAK 969
Query: 100 MEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLR 159
+E +A + +L+ A L++ + +LT+ + L + +Q+ L L E K+
Sbjct: 970 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKAL-----QEAHQQTLDDLQAEEDKVN 1024
Query: 160 NKRETKMR---------GMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKID 210
+ K++ G + +++ + M L+ +R L E K+AQ + EK+++D
Sbjct: 1025 TLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKL-EGDLKLAQESIMDIENEKQQLD 1083
Query: 211 EKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLE---ENIVIL 267
EK + ++ EIS ++E + QL++ +KE I L++ +E +
Sbjct: 1084 EKLKKKEF-----EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA 1138
Query: 268 SKQVEDLNVKCQLLEKEKED---HVNRNREHNENLNAEMQNLKQKF------------IL 312
KQ DL+ + + + + E+ + E N+ AE Q +++ L
Sbjct: 1139 EKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATL 1198
Query: 313 EQQEREKLQQKELQIDSL------LQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQT 366
++ + + + QID+L L++EK L S E + K K E+ +
Sbjct: 1199 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTL 1258
Query: 367 LDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA---ELEKSSAAHTQAT 423
D+L +L+ KEE+ +RL+ L + E +L KEA +L + A TQ
Sbjct: 1259 EDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQI 1318
Query: 424 LLLQEKYDSMVQSLEDVTAQFESYK---ALTASEIEDLKLENSSLQEKAAKAGKNAED-- 478
L+ + + +++ + +S + L + E+ + + LQ +KA
Sbjct: 1319 EELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWR 1378
Query: 479 VQHQILATESSNQ-EYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFR 537
+++ A + + + E + L + ++A + E + L+K + +L+ + ED
Sbjct: 1379 TKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK---TKQRLQNEVEDLM 1435
Query: 538 KQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHG 597
+E A + + + +W+ EE + + + Q + + E + N +
Sbjct: 1436 LDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYE 1495
Query: 598 AAQEQLNKIRDSYAKLLGH-QNLKQKIKHVVKLKDENSQLKSEVSKLRCQL-AKKKQSET 655
+ +QL ++ L +L ++I K E ++K +V + +C+L A +++E
Sbjct: 1496 ESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEA 1555
Query: 656 KLQEELNKVLGIK 668
L+ E K+L I+
Sbjct: 1556 SLEHEEGKILRIQ 1568
Score = 103 bits (256), Expect = 7e-22
Identities = 147/677 (21%), Positives = 303/677 (44%), Gaps = 89/677 (13%)
Query: 50 SKQNLNVDKDT-TLPASARKVKSSESKIRVLLQERGAQDRRIQ----DLETELEKMEARL 104
SK N++K TL ++KS E + + L+ + AQ R+Q + +L++ EA +
Sbjct: 1245 SKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALV 1304
Query: 105 NAALREKTSLSANNATLEKQLIELTRTN--------------ELLKSKFSENGN-----Q 145
+ R K + + L++QL E + +LL+ ++ E Q
Sbjct: 1305 SQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQ 1364
Query: 146 KNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIE 205
+ L + E+ + R K ET + +E E K ++ QR L+ ++ + + K S+E
Sbjct: 1365 RALSKANTEVAQWRTKYETD--AIQRTEELEEAKKKLAQR-LQAAEEHVEAVNAKCASLE 1421
Query: 206 KEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIV 265
K K ++E E L+ +E + A ++K + + ++ K+K +E + ++ ++
Sbjct: 1422 KTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEAR 1481
Query: 266 ILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKEL 325
L ++ K + +E D + + N+NL E+ +L ++ + +L++ +
Sbjct: 1482 SLGTEL----FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKK 1537
Query: 326 QIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD-KLQQKEEQAERLV 384
Q++ Q++ EL ++L + S + E K + + EL Q E+D K+ +K+E+ ++L
Sbjct: 1538 QVE---QEKCELQAALEEAEASLEHEEGKILRI-QLELNQVKSEVDRKIAEKDEEIDQLK 1593
Query: 385 KQ-----------LEEEAKSRAEELKLLEEKLKG--KEAELEKSSAAHTQATLLLQEKYD 431
+ L+ E +SR + ++L ++K++G E E++ + A A L Y
Sbjct: 1594 RNHIRIVESMQSTLDAEIRSRNDAIRL-KKKMEGDLNEMEIQLNHANRMAAEAL--RNYR 1650
Query: 432 SMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQ 491
+ L+D + AL + E DLK + + ++ +A E+++ + TE S +
Sbjct: 1651 NTQGILKDTQIHLDD--ALRSQE--DLKEQLAMVERRANLLQAEIEELRATLEQTERSRK 1706
Query: 492 EYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKE 551
+ LLD + L T+ + + + TD+ +Q++ + ED ++ + E + +
Sbjct: 1707 IAEQELLDASERVQLLHTQNTSLINTKKKLETDI-SQMQGEMEDILQEARNAEEKAKKAI 1765
Query: 552 NTTAELTEEINK-------WRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLN 604
A + EE+ K + + + K QL+LD E E+ AL ++Q+
Sbjct: 1766 TDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLD--EAEQLAL----KGGKKQIQ 1819
Query: 605 KIRDSYAKLLGHQNLKQK---------IKHVVKLKDENSQ----------LKSEVSKLRC 645
K+ +L G +QK KH ++K+ Q L+ V KL+
Sbjct: 1820 KLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQA 1879
Query: 646 QLAKKKQSETKLQEELN 662
++ K+ + +E+ N
Sbjct: 1880 KVKSYKRQAEEAEEQSN 1896
Score = 97.4 bits (241), Expect = 4e-20
Identities = 132/655 (20%), Positives = 276/655 (42%), Gaps = 88/655 (13%)
Query: 68 KVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIE 127
K+K E +I L + + L+ ++++++AR+ E + A+ A EKQ +
Sbjct: 1085 KLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD 1144
Query: 128 LTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSL 187
L+R E + + E G + +I ++ KRE + + M E ++ + T +L
Sbjct: 1145 LSRELEEISERLEEAGGATSAQI------EMNKKREAEFQKMRRDLEEATLQHEATAATL 1198
Query: 188 EESQG--------KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDI 239
+ +I L+ +EKEK + K E + L +E +S A +EK
Sbjct: 1199 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKM---- 1254
Query: 240 AQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENL 299
+ D++ LK EE + + DL + L+ E + +R + E L
Sbjct: 1255 ------CRTLEDQLSELKSKEEEQ----QRLINDLTAQRGRLQTESGEF-SRQLDEKEAL 1303
Query: 300 NAEMQNLKQKFILEQQEREKLQQKELQIDSLL------------------QQEKELSSSL 341
+++ KQ F + +E ++ ++E++ + L ++E+E + L
Sbjct: 1304 VSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAEL 1363
Query: 342 HQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLL 401
+ L E+ + + +E + Q +EL++ ++K Q + ++ E ++ L+
Sbjct: 1364 QRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKT 1423
Query: 402 EEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLE 461
+++L+ + +L A L +K ++ + + A+++ T +E+E + E
Sbjct: 1424 KQRLQNEVEDLMLDVERTNAACAALDKKQ----RNFDKILAEWKQKCEETHAELEASQKE 1479
Query: 462 NSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQK 521
SL + K E+ Q+ + N+ + + DL + A I E+ ++
Sbjct: 1480 ARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE-KIKKQ 1538
Query: 522 ITDLQNQLKQQEEDFRKQLEDEEGR-----------KAEKENTTAELTEEINKWR----- 565
+ + +L+ E+ LE EEG+ K+E + AE EEI++ +
Sbjct: 1539 VEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIR 1598
Query: 566 -------LLYEELYNKTKPFQLQL----DAFEVEKQALLNEHGAAQEQLNKIRDSYAKLL 614
L E+ ++ +L+ D E+E Q L + + A E L R++ L
Sbjct: 1599 IVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQ-LNHANRMAAEALRNYRNTQGILK 1657
Query: 615 GHQ-NLKQKIKHVVKLKDENSQ-------LKSEVSKLRCQLAKKKQSETKLQEEL 661
Q +L ++ LK++ + L++E+ +LR L + ++S ++EL
Sbjct: 1658 DTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQEL 1712
Score = 68.6 bits (166), Expect = 2e-11
Identities = 88/433 (20%), Positives = 190/433 (43%), Gaps = 65/433 (15%)
Query: 55 NVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALRE-KTS 113
++D+ TL + ++ S + + E G + ++ ++ ++E+ + L AAL E + S
Sbjct: 1497 SLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEAS 1556
Query: 114 LSANNATLEKQLIELTRTNELLKSKFSENGNQ----KNLRILSLELMKLRNKRETKMRG- 168
L + + +EL + + K +E + K I +E M+ E + R
Sbjct: 1557 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRND 1616
Query: 169 ---MMAKQEG--MEMKLQV-----------------------TQRSLEESQGKIAQLEGK 200
+ K EG EM++Q+ TQ L+++ L+ +
Sbjct: 1617 AIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQ 1676
Query: 201 LVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSL 260
L +E+ ++E E+L +E+ + E+ LD ++ + L +N +++ K+ L
Sbjct: 1677 LAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKL 1736
Query: 261 EENIVILSKQVEDLNVKCQLLEKEKE----------DHVNRNREHNENLNAEMQNLKQ-- 308
E +I + ++ED+ + + E++ + + + + ++ + +L +N++Q
Sbjct: 1737 ETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTV 1796
Query: 309 ---KFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQ---------KLCSFQEEMVKEK 356
+ L++ E+ L+ + QI L + +EL + K E VKE
Sbjct: 1797 KDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKEL 1856
Query: 357 NLFEEELKQTL----DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAEL 412
EE ++ + D +DKLQ K + +R ++ EE++ + + + L+ +L +EAE
Sbjct: 1857 TYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHEL--EEAE- 1913
Query: 413 EKSSAAHTQATLL 425
E++ A +Q L
Sbjct: 1914 ERADIAESQVNKL 1926
Score = 67.0 bits (162), Expect = 6e-11
Identities = 81/362 (22%), Positives = 160/362 (44%), Gaps = 42/362 (11%)
Query: 67 RKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEK--- 123
R V+S +S + ++ R R + +E +L +ME +LN A R N +
Sbjct: 1598 RIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILK 1657
Query: 124 ----QLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRE-TKMRGMMAKQEGMEM 178
L + R+ E LK + + + NL L E+ +LR E T+ +A+QE ++
Sbjct: 1658 DTQIHLDDALRSQEDLKEQLAMVERRANL--LQAEIEELRATLEQTERSRKIAEQELLDA 1715
Query: 179 KLQV------------TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEIS 226
+V T++ LE I+Q++G++ I +E ++ EK + I + +
Sbjct: 1716 SERVQLLHTQNTSLINTKKKLETD---ISQMQGEMEDILQEA---RNAEEKAKKAITDAA 1769
Query: 227 CASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVIL----SKQVEDLNVKCQLLE 282
+++++K + A LE K + L+ L+E + KQ++ L + + LE
Sbjct: 1770 MMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELE 1829
Query: 283 KEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLH 342
E E RN E + L + +K+ +++R+ + + + +D L + K
Sbjct: 1830 GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQ-- 1887
Query: 343 QKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLE 402
EE ++ N + ++ EL++ +++ + AE V +L KSR K++
Sbjct: 1888 ------AEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL--RVKSREVHTKVIS 1939
Query: 403 EK 404
E+
Sbjct: 1940 EE 1941
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 116 bits (290), Expect = 8e-26
Identities = 137/564 (24%), Positives = 266/564 (47%), Gaps = 86/564 (15%)
Query: 156 MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 213
MKL K + ++ ++E MK Q + L +S+ K +LE K+V++ KEK D +
Sbjct: 836 MKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL 895
Query: 214 ETEKLLEYIEEISCASDQVEKYKL-------DIAQLEENLKEKNDEILSLKQSLEENIVI 266
+ + E + + DQ+ K K+ ++ + E+ +E N E+ + K+ LE+
Sbjct: 896 QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955
Query: 267 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK--- 323
L K ++DL + +EKEK H N+ +NL EM L + +E++ LQ+
Sbjct: 956 LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1011
Query: 324 ----------------------ELQIDSL---LQQEKELSSSLHQK-------LCSFQEE 351
E Q+D L L+QEK+L L + L QE
Sbjct: 1012 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071
Query: 352 MV---KEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK 408
++ EK +E+LK+ E+ LQ K E + L QL+++ K ++ LEE+++ +
Sbjct: 1072 IMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAE 1131
Query: 409 EAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLK--LENSSLQ 466
A K+ + + L+E + + ++ +AQ E K A E + ++ LE ++LQ
Sbjct: 1132 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA-EFQKMRRDLEEATLQ 1190
Query: 467 EKAAKA---GKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKIT 523
+A A K+A+ V L + N + V+ L+ + KS +K EI ++ S ++ ++
Sbjct: 1191 HEATAATLRKKHADSVAE--LGEQIDNLQRVKQKLE-KEKSEMK-MEIDDL-ASNVETVS 1245
Query: 524 DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLD 583
+ L++ QL + + ++ E++ +LT + + L ++ F QLD
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGR-------LQTESGEFSRQLD 1298
Query: 584 AFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL----KSE 639
EK+AL++ QL++ + ++ + + + LK++++ +K K+ + + +
Sbjct: 1299 ----EKEALVS-------QLSRGKQAFTQQI--EELKRQLEEEIKAKNALAHALQSSRHD 1345
Query: 640 VSKLRCQLAKKKQSETKLQEELNK 663
LR Q ++++S+ +LQ L+K
Sbjct: 1346 CDLLREQYEEEQESKAELQRALSK 1369
Score = 107 bits (266), Expect = 5e-23
Identities = 139/673 (20%), Positives = 290/673 (43%), Gaps = 72/673 (10%)
Query: 40 KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEK 99
K + ++ E ++ +N + L A RK++ S+++ + I DLE L K
Sbjct: 924 KIKEVTERAEDEEEINAE----LTAKKRKLEDECSELK----------KDIDDLELTLAK 969
Query: 100 MEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLR 159
+E +A + +L+ A L++ + +LT+ + L + +Q+ L L E K+
Sbjct: 970 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKAL-----QEAHQQTLDDLQAEEDKVN 1024
Query: 160 NKRETKMR---------GMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKID 210
+ K++ G + +++ + M L+ +R L E K+AQ + EK+++D
Sbjct: 1025 TLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKL-EGDLKLAQESIMDIENEKQQLD 1083
Query: 211 EKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLE---ENIVIL 267
EK + ++ EIS ++E + QL++ +KE I L++ +E +
Sbjct: 1084 EKLKKKEF-----EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA 1138
Query: 268 SKQVEDLNVKCQLLEKEKED---HVNRNREHNENLNAEMQNLKQKF------------IL 312
KQ DL+ + + + + E+ + E N+ AE Q +++ L
Sbjct: 1139 EKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATL 1198
Query: 313 EQQEREKLQQKELQIDSL------LQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQT 366
++ + + + QID+L L++EK L S E + K K E+ +
Sbjct: 1199 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTL 1258
Query: 367 LDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA---ELEKSSAAHTQAT 423
D+L +L+ KEE+ +RL+ L + E +L KEA +L + A TQ
Sbjct: 1259 EDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQI 1318
Query: 424 LLLQEKYDSMVQSLEDVTAQFESYK---ALTASEIEDLKLENSSLQEKAAKAGKNAED-- 478
L+ + + +++ + +S + L + E+ + + LQ +KA
Sbjct: 1319 EELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWR 1378
Query: 479 VQHQILATESSNQ-EYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFR 537
+++ A + + + E + L + ++A + E + L+K + +L+ + ED
Sbjct: 1379 TKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK---TKQRLQNEVEDLM 1435
Query: 538 KQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHG 597
+E A + + + +W+ EE + + + Q + + E + N +
Sbjct: 1436 LDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYE 1495
Query: 598 AAQEQLNKIRDSYAKLLGH-QNLKQKIKHVVKLKDENSQLKSEVSKLRCQL-AKKKQSET 655
+ +QL ++ L +L ++I K E ++K +V + +C+L A +++E
Sbjct: 1496 ESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEA 1555
Query: 656 KLQEELNKVLGIK 668
L+ E K+L I+
Sbjct: 1556 SLEHEEGKILRIQ 1568
Score = 103 bits (256), Expect = 7e-22
Identities = 147/677 (21%), Positives = 303/677 (44%), Gaps = 89/677 (13%)
Query: 50 SKQNLNVDKDT-TLPASARKVKSSESKIRVLLQERGAQDRRIQ----DLETELEKMEARL 104
SK N++K TL ++KS E + + L+ + AQ R+Q + +L++ EA +
Sbjct: 1245 SKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALV 1304
Query: 105 NAALREKTSLSANNATLEKQLIELTRTN--------------ELLKSKFSENGN-----Q 145
+ R K + + L++QL E + +LL+ ++ E Q
Sbjct: 1305 SQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQ 1364
Query: 146 KNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIE 205
+ L + E+ + R K ET + +E E K ++ QR L+ ++ + + K S+E
Sbjct: 1365 RALSKANTEVAQWRTKYETD--AIQRTEELEEAKKKLAQR-LQAAEEHVEAVNAKCASLE 1421
Query: 206 KEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIV 265
K K ++E E L+ +E + A ++K + + ++ K+K +E + ++ ++
Sbjct: 1422 KTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEAR 1481
Query: 266 ILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKEL 325
L ++ K + +E D + + N+NL E+ +L ++ + +L++ +
Sbjct: 1482 SLGTEL----FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKK 1537
Query: 326 QIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD-KLQQKEEQAERLV 384
Q++ Q++ EL ++L + S + E K + + EL Q E+D K+ +K+E+ ++L
Sbjct: 1538 QVE---QEKCELQAALEEAEASLEHEEGKILRI-QLELNQVKSEVDRKIAEKDEEIDQLK 1593
Query: 385 KQ-----------LEEEAKSRAEELKLLEEKLKG--KEAELEKSSAAHTQATLLLQEKYD 431
+ L+ E +SR + ++L ++K++G E E++ + A A L Y
Sbjct: 1594 RNHIRIVESMQSTLDAEIRSRNDAIRL-KKKMEGDLNEMEIQLNHANRMAAEAL--RNYR 1650
Query: 432 SMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQ 491
+ L+D + AL + E DLK + + ++ +A E+++ + TE S +
Sbjct: 1651 NTQGILKDTQIHLDD--ALRSQE--DLKEQLAMVERRANLLQAEIEELRATLEQTERSRK 1706
Query: 492 EYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKE 551
+ LLD + L T+ + + + TD+ +Q++ + ED ++ + E + +
Sbjct: 1707 IAEQELLDASERVQLLHTQNTSLINTKKKLETDI-SQMQGEMEDILQEARNAEEKAKKAI 1765
Query: 552 NTTAELTEEINK-------WRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLN 604
A + EE+ K + + + K QL+LD E E+ AL ++Q+
Sbjct: 1766 TDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLD--EAEQLAL----KGGKKQIQ 1819
Query: 605 KIRDSYAKLLGHQNLKQK---------IKHVVKLKDENSQ----------LKSEVSKLRC 645
K+ +L G +QK KH ++K+ Q L+ V KL+
Sbjct: 1820 KLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQA 1879
Query: 646 QLAKKKQSETKLQEELN 662
++ K+ + +E+ N
Sbjct: 1880 KVKSYKRQAEEAEEQSN 1896
Score = 97.4 bits (241), Expect = 4e-20
Identities = 132/655 (20%), Positives = 276/655 (42%), Gaps = 88/655 (13%)
Query: 68 KVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIE 127
K+K E +I L + + L+ ++++++AR+ E + A+ A EKQ +
Sbjct: 1085 KLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD 1144
Query: 128 LTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSL 187
L+R E + + E G + +I ++ KRE + + M E ++ + T +L
Sbjct: 1145 LSRELEEISERLEEAGGATSAQI------EMNKKREAEFQKMRRDLEEATLQHEATAATL 1198
Query: 188 EESQG--------KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDI 239
+ +I L+ +EKEK + K E + L +E +S A +EK
Sbjct: 1199 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKM---- 1254
Query: 240 AQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENL 299
+ D++ LK EE + + DL + L+ E + +R + E L
Sbjct: 1255 ------CRTLEDQLSELKSKEEEQ----QRLINDLTAQRGRLQTESGEF-SRQLDEKEAL 1303
Query: 300 NAEMQNLKQKFILEQQEREKLQQKELQIDSLL------------------QQEKELSSSL 341
+++ KQ F + +E ++ ++E++ + L ++E+E + L
Sbjct: 1304 VSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAEL 1363
Query: 342 HQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLL 401
+ L E+ + + +E + Q +EL++ ++K Q + ++ E ++ L+
Sbjct: 1364 QRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKT 1423
Query: 402 EEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLE 461
+++L+ + +L A L +K ++ + + A+++ T +E+E + E
Sbjct: 1424 KQRLQNEVEDLMLDVERTNAACAALDKKQ----RNFDKILAEWKQKCEETHAELEASQKE 1479
Query: 462 NSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQK 521
SL + K E+ Q+ + N+ + + DL + A I E+ ++
Sbjct: 1480 ARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE-KIKKQ 1538
Query: 522 ITDLQNQLKQQEEDFRKQLEDEEGR-----------KAEKENTTAELTEEINKWR----- 565
+ + +L+ E+ LE EEG+ K+E + AE EEI++ +
Sbjct: 1539 VEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIR 1598
Query: 566 -------LLYEELYNKTKPFQLQL----DAFEVEKQALLNEHGAAQEQLNKIRDSYAKLL 614
L E+ ++ +L+ D E+E Q L + + A E L R++ L
Sbjct: 1599 IVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQ-LNHANRMAAEALRNYRNTQGILK 1657
Query: 615 GHQ-NLKQKIKHVVKLKDENSQ-------LKSEVSKLRCQLAKKKQSETKLQEEL 661
Q +L ++ LK++ + L++E+ +LR L + ++S ++EL
Sbjct: 1658 DTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQEL 1712
Score = 68.6 bits (166), Expect = 2e-11
Identities = 88/433 (20%), Positives = 190/433 (43%), Gaps = 65/433 (15%)
Query: 55 NVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALRE-KTS 113
++D+ TL + ++ S + + E G + ++ ++ ++E+ + L AAL E + S
Sbjct: 1497 SLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEAS 1556
Query: 114 LSANNATLEKQLIELTRTNELLKSKFSENGNQ----KNLRILSLELMKLRNKRETKMRG- 168
L + + +EL + + K +E + K I +E M+ E + R
Sbjct: 1557 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRND 1616
Query: 169 ---MMAKQEG--MEMKLQV-----------------------TQRSLEESQGKIAQLEGK 200
+ K EG EM++Q+ TQ L+++ L+ +
Sbjct: 1617 AIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQ 1676
Query: 201 LVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSL 260
L +E+ ++E E+L +E+ + E+ LD ++ + L +N +++ K+ L
Sbjct: 1677 LAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKL 1736
Query: 261 EENIVILSKQVEDLNVKCQLLEKEKE----------DHVNRNREHNENLNAEMQNLKQ-- 308
E +I + ++ED+ + + E++ + + + + ++ + +L +N++Q
Sbjct: 1737 ETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTV 1796
Query: 309 ---KFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQ---------KLCSFQEEMVKEK 356
+ L++ E+ L+ + QI L + +EL + K E VKE
Sbjct: 1797 KDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKEL 1856
Query: 357 NLFEEELKQTL----DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAEL 412
EE ++ + D +DKLQ K + +R ++ EE++ + + + L+ +L +EAE
Sbjct: 1857 TYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHEL--EEAE- 1913
Query: 413 EKSSAAHTQATLL 425
E++ A +Q L
Sbjct: 1914 ERADIAESQVNKL 1926
Score = 67.0 bits (162), Expect = 6e-11
Identities = 81/362 (22%), Positives = 160/362 (44%), Gaps = 42/362 (11%)
Query: 67 RKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEK--- 123
R V+S +S + ++ R R + +E +L +ME +LN A R N +
Sbjct: 1598 RIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILK 1657
Query: 124 ----QLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRE-TKMRGMMAKQEGMEM 178
L + R+ E LK + + + NL L E+ +LR E T+ +A+QE ++
Sbjct: 1658 DTQIHLDDALRSQEDLKEQLAMVERRANL--LQAEIEELRATLEQTERSRKIAEQELLDA 1715
Query: 179 KLQV------------TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEIS 226
+V T++ LE I+Q++G++ I +E ++ EK + I + +
Sbjct: 1716 SERVQLLHTQNTSLINTKKKLETD---ISQMQGEMEDILQEA---RNAEEKAKKAITDAA 1769
Query: 227 CASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVIL----SKQVEDLNVKCQLLE 282
+++++K + A LE K + L+ L+E + KQ++ L + + LE
Sbjct: 1770 MMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELE 1829
Query: 283 KEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLH 342
E E RN E + L + +K+ +++R+ + + + +D L + K
Sbjct: 1830 GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQ-- 1887
Query: 343 QKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLE 402
EE ++ N + ++ EL++ +++ + AE V +L KSR K++
Sbjct: 1888 ------AEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL--RVKSREVHTKVIS 1939
Query: 403 EK 404
E+
Sbjct: 1940 EE 1941
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 115 bits (287), Expect = 2e-25
Identities = 144/667 (21%), Positives = 299/667 (44%), Gaps = 71/667 (10%)
Query: 51 KQNLNVDKDTTLPASA-------RKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEAR 103
K NL +K TL + A + +S S+++ LL+++ + +L+ +L+
Sbjct: 577 KVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKN 636
Query: 104 LNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKL-RNKR 162
E+ + AN L Q E N L+ + E+ + + L +K+ R +
Sbjct: 637 QQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQH 696
Query: 163 ETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYI 222
+T++R + + M +L +RS + +G + + + ++ + K E E LL
Sbjct: 697 QTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKR 756
Query: 223 E-EISCASDQVEKYKLDIAQLEENLKEKND-EILSLKQSLEENIVILSKQVEDLNVKCQL 280
E E++ +++ Q + LKE+ D E+ +L++S+EE +K VE L +
Sbjct: 757 ERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEE----ATKNVEVLASRSNT 812
Query: 281 LEKEK---EDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKEL 337
E+++ E V +E NE L + L+++ Q++ E L+ E + L++ +
Sbjct: 813 SEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGE 872
Query: 338 SSSLHQKLCSF---QEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSR 394
L + L ++E V + E EL+ L + Q+++Q L ++L+EE++ +
Sbjct: 873 IRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQ---LSEKLKEESEQK 929
Query: 395 AEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTA----QFESYKAL 450
E+L+ L+ +++ + L K+ LQ++ +V++ T Q + YK
Sbjct: 930 -EQLRRLKNEMENERWHLGKTIEK-------LQKEMADIVEASRTSTLELQNQLDEYKEK 981
Query: 451 TASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETE 510
E+ +++ + +A K+ A +Q ++ E ++Y R + TK L E
Sbjct: 982 NRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQT 1041
Query: 511 IKEITVSFLQK--ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLY 568
+K++ K + D +++L +Q ED QLE E E+ N + L+E I++ R
Sbjct: 1042 LKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEME---LEEERNNSDLLSERISRSREQM 1098
Query: 569 EELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSY---------------AKL 613
E+L N+ + E +K +L ++ + ++ + SY A+L
Sbjct: 1099 EQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAEL 1158
Query: 614 ---------------LGHQNLKQKIKHVV-KLKDENSQLKSEVSKLRCQLAKKKQSETKL 657
L ++ L++K+K +V ++ DE+ L + +L +L K+ +
Sbjct: 1159 EDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEA 1218
Query: 658 QEELNKV 664
+EE++++
Sbjct: 1219 EEEIDRL 1225
Score = 105 bits (261), Expect = 2e-22
Identities = 134/576 (23%), Positives = 268/576 (46%), Gaps = 76/576 (13%)
Query: 115 SANNATLEKQLIELTRTN-ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAK- 172
S +N K+ + L + LKS+ + + N S +K ++++K+ +A+
Sbjct: 567 STDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAEL 626
Query: 173 QEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEY--------IEE 224
Q ++++++ Q EE + A LE +L S EK++E S ++ LE +EE
Sbjct: 627 QRQLQLEVKNQQNIKEERERMRANLE-ELRSQHNEKVEENSTLQQRLEESEGELRKNLEE 685
Query: 225 ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQS-------LEENIVILSKQVEDLNVK 277
+ + E+++ +I L++ L E +DE+ S K+S L E ++ + ++DL
Sbjct: 686 LFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDL--- 742
Query: 278 CQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKL-QQKELQIDSLLQQEKE 336
L+ KE+++ + R RE L A LK++ QE +KL +Q + ++ +L + +E
Sbjct: 743 --LIAKEEQEDLLRKRERE--LTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEE 798
Query: 337 LSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAE 396
+ ++ + L S +++ E +K +E +KLQ + E+ ER V QL+ +
Sbjct: 799 ATKNV-EVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQI----- 852
Query: 397 ELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLED--VTAQFESYKALTA-- 452
E LKG EA+ +++ +KY+ ++ LE+ V A+ E +A++A
Sbjct: 853 ------EDLKGDEAKAKET-----------LKKYEGEIRQLEEALVHARKEEKEAVSARR 895
Query: 453 ---SEIEDLK--LENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALK 507
+E+E + L ++ ++K E Q + L + E R L + K
Sbjct: 896 ALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQK 955
Query: 508 ETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLL 567
E+ +I + +LQNQL + +E R++L AE + E T E K RL
Sbjct: 956 --EMADIVEASRTSTLELQNQLDEYKEKNRREL-------AEMQRQLKEKTLEAEKSRLT 1006
Query: 568 YEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVV 627
++ ++ + + +L ++ + L + ++ L +D +L +LK +V
Sbjct: 1007 AMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTL---KDLEYELEAKSHLKDDRSRLV 1063
Query: 628 KLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNK 663
K Q++ +VS+L +L +++ + L E +++
Sbjct: 1064 K------QMEDKVSQLEMELEEERNNSDLLSERISR 1093
Score = 98.2 bits (243), Expect = 2e-20
Identities = 142/628 (22%), Positives = 275/628 (43%), Gaps = 111/628 (17%)
Query: 46 QQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQE-------RGAQDRRIQDLETELE 98
++ S+ N V++++TL ++++ SE ++R L+E R I+DL+ +L
Sbjct: 652 EELRSQHNEKVEENSTLQ---QRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLS 708
Query: 99 KMEARLNAALR----EKTSL------------------SANNATLEKQLIELTRTNELLK 136
+M L++A R EK +L L K+ ELT LK
Sbjct: 709 EMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALK 768
Query: 137 SKFSENGNQ--KNLRILSLELMKLRNKRE--TKMRGMMAK--------QEGMEMKLQVTQ 184
+ S + + K EL LR E TK ++A Q G EM++++ Q
Sbjct: 769 EEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQ 828
Query: 185 RSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEE 244
E+ QG+ +LE ++ ++++ D K + K A + ++KY+ +I QLEE
Sbjct: 829 EENEKLQGRSEELERRVAQLQRQIEDLKGDEAK----------AKETLKKYEGEIRQLEE 878
Query: 245 NL---KEKNDEILSLKQSLEENIVILSKQV-EDLNVKCQLLEKEKEDHVNRNREHNENLN 300
L +++ E +S +++LE + + + + QL EK KE+ + +E L
Sbjct: 879 ALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEE--SEQKEQLRRLK 936
Query: 301 AEMQNLKQKF--ILEQQEREKLQQKELQIDSLLQQEKELSS---SLHQKLCSFQEEMVKE 355
EM+N + +E+ ++E E S L+ + +L ++L Q ++ KE
Sbjct: 937 NEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQL-KE 995
Query: 356 KNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKS 415
K L E+ + T ++ + E+ R ++ ++EA ++ + LLE+ LK E ELE
Sbjct: 996 KTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQ---LLEQTLKDLEYELEAK 1052
Query: 416 SAAHTQATLLLQEKYDSMVQ---SLEDVTAQFESYKALTASEIEDLK-LENSSLQEKAAK 471
S + L+++ D + Q LE+ + + E ++ L N LQE+AA+
Sbjct: 1053 SHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAAR 1112
Query: 472 AG---------KNAEDVQHQILATESSNQEYVRMLL----------------------DL 500
+ +D++ +I+ E S + L+ +L
Sbjct: 1113 QDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANL 1172
Query: 501 QTKSALKETEIKEITVSFLQK---ITDLQNQLKQQEEDFRKQLEDEEGR----KAEKENT 553
Q + E ++KE+ + + +TD ++QL + + ++Q+E+ E ++ K+
Sbjct: 1173 QLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKL 1232
Query: 554 TAELTEEINKWRLLYEELYNKTKPFQLQ 581
EL E+++ L +L + K +L+
Sbjct: 1233 QRELEEQMDMNEHLQGQLNSMKKDLRLK 1260
Score = 63.9 bits (154), Expect = 5e-10
Identities = 101/454 (22%), Positives = 195/454 (42%), Gaps = 64/454 (14%)
Query: 67 RKVKSSESKIRVLLQERGAQDRRIQDLETELEKME-ARLNAALREKTSLSANNA------ 119
R+V + +I L + ++ E E+ ++E A ++A EK ++SA A
Sbjct: 843 RRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELE 902
Query: 120 TLEKQLIELTRTNELLKSKFSENGNQKN-LRILSLELMKLR-------NKRETKMRGMMA 171
+ L + T+ + L K E QK LR L E+ R K + +M ++
Sbjct: 903 AAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVE 962
Query: 172 KQEGMEMKLQ--------VTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIE 223
++LQ +R L E Q QL+ K + EK ++ +++ E
Sbjct: 963 ASRTSTLELQNQLDEYKEKNRRELAEMQ---RQLKEKTLEAEKSRLTAMKMQDEMRLMEE 1019
Query: 224 EISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQL-LE 282
E+ ++ LE+ LK+ E L K L+++ L KQ+ED + ++ LE
Sbjct: 1020 ELRDYQRAQDEALTKRQLLEQTLKDLEYE-LEAKSHLKDDRSRLVKQMEDKVSQLEMELE 1078
Query: 283 KEKE------DHVNRNREHNENLNAEM-------QNLK-QKFILEQQEREKLQQKELQID 328
+E+ + ++R+RE E L E+ Q+L+ K LE+Q ++ L+ + + ++
Sbjct: 1079 EERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKD-LKSRIIHLE 1137
Query: 329 SLLQQEKE-LSSSLHQKLCSFQEEMVKEK----NL------FEEELKQTLDELD----KL 373
+ KE L + ++ ++ + E+ NL E ++K+ + ++D L
Sbjct: 1138 GSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSL 1197
Query: 374 QQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSM 433
+++Q +K ++ + + EE+ LE K + ELE+ + LQ + +SM
Sbjct: 1198 TDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEH----LQGQLNSM 1253
Query: 434 VQSLEDVTAQFESYKALTASEIEDLKLENSSLQE 467
+ L + S + +DL + SL E
Sbjct: 1254 KKDLR--LKKLPSKVLDDMDDDDDLSTDGGSLYE 1285
Score = 45.1 bits (105), Expect = 2e-04
Identities = 39/198 (19%), Positives = 96/198 (48%), Gaps = 18/198 (9%)
Query: 46 QQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQE---RGAQDRRIQDLETELEKMEA 102
Q++ ++Q+L DK + + ++ + K R++ E R +++ + +E + ++E
Sbjct: 1107 QERAARQDLECDKISL------ERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELED 1160
Query: 103 RLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKR 162
RL + R++ +L +N LE+++ EL + ++ +Q +LR+ +++ +
Sbjct: 1161 RLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEE 1220
Query: 163 ETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYI 222
E + +E + QR LEE L+G+L S++K+ +K ++ L +
Sbjct: 1221 EI---------DRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLDDMD 1271
Query: 223 EEISCASDQVEKYKLDIA 240
++ ++D Y+ ++
Sbjct: 1272 DDDDLSTDGGSLYEAPVS 1289
Score = 36.6 bits (83), Expect = 0.082
Identities = 54/241 (22%), Positives = 98/241 (40%), Gaps = 42/241 (17%)
Query: 459 KLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSF 518
KL+ ++ A + ++ ++L TE S + V L +S KE E+K T +
Sbjct: 446 KLQGAAHGASCAHSRPPQPNIDGKVLETEGSQESTVIRAPSLGAQSK-KEEEVKTATATL 504
Query: 519 LQKITDLQNQLKQQEEDF-RKQLEDEEGRKAEKENTTA-------ELTEEINKWRLLYEE 570
+ LQN+ D K++ + A T ELT++ N+ +
Sbjct: 505 M-----LQNRATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNE-ETAKQI 558
Query: 571 LYNKTKPFQLQLDAFEVEKQALLNEH---------GAAQ----------------EQLNK 605
LYN K D K L+ E G+AQ EQ +K
Sbjct: 559 LYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSK 618
Query: 606 IRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVL 665
+ A+L + L+ ++K+ +K+E ++++ + +LR Q +K + + LQ+ L +
Sbjct: 619 LTIEVAEL--QRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESE 676
Query: 666 G 666
G
Sbjct: 677 G 677
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 114 bits (286), Expect = 2e-25
Identities = 132/569 (23%), Positives = 250/569 (43%), Gaps = 64/569 (11%)
Query: 156 MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKID--- 210
M L K + ++ A++E MK + T+ L S+ + +LE K+VS+ +EK D
Sbjct: 834 MNLFFKIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQL 893
Query: 211 -EKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEK---NDEILSLKQSLEENIVI 266
+SETE L++ E + + +L E L+E+ N E+++ K++LE+
Sbjct: 894 QVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSS 953
Query: 267 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNL----KQKFILE---QQEREK 319
L + ++DL + +EKEK N+ + +E + A +N+ K+K L+ QQ +
Sbjct: 954 LKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDD 1013
Query: 320 LQQKELQIDSLL-------QQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDK 372
LQ +E +++ L+ QQ +L SL Q+ + ++ + K E +LK + + +
Sbjct: 1014 LQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEK-KLRADLERAKRKLEGDLKMSQESIMD 1072
Query: 373 LQQKEEQAERLVKQLEEE-----AKSRAEELKLLEEKLKGKE-----AELEKSSAAHTQA 422
L+ ++Q E +K+ E E AK E++ L+ + K KE ELE+ A
Sbjct: 1073 LENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTL 1132
Query: 423 TLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLK------------LENSSLQEKAA 470
++++ + + LE+++ + E T+++IE K LE ++LQ +A
Sbjct: 1133 RAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEAT 1192
Query: 471 KA---GKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQK------ 521
A K A+ V L + N + V+ L+ + E + + L K
Sbjct: 1193 AATLRKKQADSVAE--LGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIE 1250
Query: 522 -----ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTK 576
+ D +++K ++E + + D +KA + EL+ + + L +L +
Sbjct: 1251 RTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQ 1310
Query: 577 PFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL 636
QL+ + + + A L R L +Q+ K +L+ S+
Sbjct: 1311 ALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAK--AELQRALSKA 1368
Query: 637 KSEVSKLRCQLAKKKQSETKLQEELNKVL 665
SEV++ R + T+ EE K L
Sbjct: 1369 NSEVAQWRTKYETDAIQRTEELEEAKKKL 1397
Score = 107 bits (268), Expect = 3e-23
Identities = 136/665 (20%), Positives = 283/665 (42%), Gaps = 74/665 (11%)
Query: 45 KQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARL 104
K +ES +L DK K+K E ++ L + + + ++++++AR+
Sbjct: 1064 KMSQESIMDLENDKQQI----EEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARI 1119
Query: 105 NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET 164
E + A +EKQ +L R E + + E + +I ++ KRE
Sbjct: 1120 EELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQI------EMNKKREA 1173
Query: 165 KMRGMMAKQEGMEMKLQVTQRSLEESQG--------KIAQLEGKLVSIEKEKIDEKSETE 216
+ + M E ++ + T +L + Q +I L+ +EKEK + K E +
Sbjct: 1174 EFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEID 1233
Query: 217 KLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNV 276
+ IE +S + +E+ + +K K+++ L L L Q +L+
Sbjct: 1234 DMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSH 1293
Query: 277 KCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREK------LQQKELQIDSL 330
+ + EKE +++ + + L +++ LK++ +E++ + K LQ D L
Sbjct: 1294 RVE----EKESLISQLTKSKQALTQQLEELKRQ--MEEETKAKNAMAHALQSSRHDCDLL 1347
Query: 331 LQQ---EKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQL 387
+Q E+E + L + L E+ + + +E + Q +EL++ ++K Q + ++
Sbjct: 1348 REQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEN 1407
Query: 388 EEEAKSRAEELKLLEEKLKGKEAELEKS-SAAHTQATLLLQEKYDSMVQSLEDVTAQFES 446
E A S+ L+ +++L+G+ +L + +HT L D ++ + V A+++
Sbjct: 1408 TETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATL-----DKKQRNFDKVLAEWKQ 1462
Query: 447 YKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSAL 506
+ +E+E + E+ SL + K E+V Q+ N+ + DL
Sbjct: 1463 KLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDL------ 1516
Query: 507 KETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRL 566
TE T LQ+ + ++Q++ D + LE+ EG +E+ + E+++
Sbjct: 1517 --TEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQ--- 1571
Query: 567 LYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHV 626
+ EL K ++ E +Q N AA E L + D+ + +N ++K
Sbjct: 1572 VKSELDRKV------IEKDEEIEQLKRNSQRAA-EALQSVLDAEIR---SRNDALRLK-- 1619
Query: 627 VKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLG-IK----HFDPSKAFHHESK 681
+++ +++++ QL + + Q+ L V G +K H D + + + K
Sbjct: 1620 -------KKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLK 1672
Query: 682 ENFAL 686
E A+
Sbjct: 1673 EQLAI 1677
Score = 103 bits (257), Expect = 5e-22
Identities = 136/672 (20%), Positives = 284/672 (42%), Gaps = 67/672 (9%)
Query: 74 SKIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNE 133
+K R L + + R I DLE L K+E +A + +LS LE+ + +LT+
Sbjct: 942 AKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTK--- 998
Query: 134 LLKSKFSENGNQKNLRILSLE------LMKLRNKRETK---MRGMMAKQEGMEMKLQVTQ 184
+ K + +Q+ L L +E L+K+ K E + + G + +++ + L+ +
Sbjct: 999 --EKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAK 1056
Query: 185 RSLE----ESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIA 240
R LE SQ I LE IE++ ++ E +L I++ S Q +K ++
Sbjct: 1057 RKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQ 1116
Query: 241 QLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLN 300
E L+E+ + +L+ +E+ L++++E+++ + + + N++
Sbjct: 1117 ARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQ 1176
Query: 301 AEMQNLKQKFILEQQEREKLQQKEL--------QIDSL------LQQEKELSSSLHQKLC 346
++L++ + + L++K+ QID+L L++EK +
Sbjct: 1177 KMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMA 1236
Query: 347 SFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLK 406
S E + K K+ E + D+ +++ K+EQ +L+ L + + L +++
Sbjct: 1237 SNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVE 1296
Query: 407 GKE---AELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENS 463
KE ++L KS A TQ L+ + + E+ A+ AL +S + L
Sbjct: 1297 EKESLISQLTKSKQALTQQLEELKRQME------EETKAKNAMAHALQSSRHDCDLLREQ 1350
Query: 464 SLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKIT 523
+E+ AKA ++Q A +N E + +T + + E++E Q++
Sbjct: 1351 YEEEQEAKA-----ELQR---ALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1402
Query: 524 DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTK---PFQL 580
+ + + + ++ + E E+ +L L ++ N K ++
Sbjct: 1403 EAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQ 1462
Query: 581 QLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEV 640
+LD + E +A E + +L K+R++Y ++ + + L+ EN L+ E+
Sbjct: 1463 KLDESQAELEAAQKESRSLSTELFKMRNAY---------EEVVDQLETLRRENKNLQEEI 1513
Query: 641 SKLRCQLA------KKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGN 694
S L Q+A ++ + KL E+ L + + + HE + ++ L +
Sbjct: 1514 SDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVK 1573
Query: 695 TNCYRAPMECQE 706
+ R +E E
Sbjct: 1574 SELDRKVIEKDE 1585
Score = 83.6 bits (205), Expect = 6e-16
Identities = 135/636 (21%), Positives = 279/636 (43%), Gaps = 99/636 (15%)
Query: 42 QRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKME 101
QR ++ +E+K+ L A++++ +E + + ++ Q L+ E+E +
Sbjct: 1385 QRTEELEEAKKKL-----------AQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLM 1433
Query: 102 ARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNK 161
L + +L +K L E + +L +S+ QK R LS EL K+RN
Sbjct: 1434 RDLERSHTACATLDKKQRNFDKVLAEWKQ--KLDESQAELEAAQKESRSLSTELFKMRNA 1491
Query: 162 RETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKI---DEKSETEKL 218
E ++ + E + + + Q + + +IA+ L EK K EKS+ +
Sbjct: 1492 YEE----VVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVA 1547
Query: 219 LEYIE-EISCASDQVEKYKLDIAQLEENLK----EKNDEILSLKQSLEENIVILSKQVED 273
LE +E + ++ + +L+++Q++ L EK++EI LK++ + L + V D
Sbjct: 1548 LEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEAL-QSVLD 1606
Query: 274 LNVKCQ----LLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDS 329
++ + L+K+ E +N + N +M ++ Q + L+ +L +D
Sbjct: 1607 AEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQ---LKDSQLHLDD 1663
Query: 330 LLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEE 389
L+ ++L L +V+ +N L+EL++++ EQ ER + E+
Sbjct: 1664 ALRSNEDLKEQL---------AIVERRNGL------LLEELEEMKVALEQTERTRRLSEQ 1708
Query: 390 EAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKA 449
E ++ ++LL H+Q T L+ K + LE AQ ++
Sbjct: 1709 ELLDASDRVQLL-----------------HSQNTSLINTK-----KKLEADIAQCQA--- 1743
Query: 450 LTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDL-QTKSALKE 508
E+E+ E+ + +EKA KA +A + ++ + ++ RM +L QT L+
Sbjct: 1744 ----EVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQH 1799
Query: 509 --TEIKEITVSFLQK-ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWR 565
E +++ + +K I L+N++++ E +L+ E+ R AE + ++ +
Sbjct: 1800 RLDEAEQLALKGGKKQIQKLENRVRELE----NELDVEQKRGAEALKGAHKYERKVKEMT 1855
Query: 566 LLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKH 625
EE + Q +D + + ++ + A+EQ N + ++++H
Sbjct: 1856 YQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANT----------QLSRCRRVQH 1905
Query: 626 VVKLKDENSQL-KSEVSKLRCQLAKKKQSETKLQEE 660
++ E + + +S+V+KLR AK + ++ EE
Sbjct: 1906 ELEEAAERADIAESQVNKLR---AKSRDVGSQKMEE 1938
Score = 30.0 bits (66), Expect = 7.7
Identities = 36/159 (22%), Positives = 69/159 (43%), Gaps = 26/159 (16%)
Query: 519 LQKITDLQNQLKQQEEDFRKQLED---EEGRKAEKENTTAELTEEINKWRLLYEELYNKT 575
L K + + ++ +EDF + E+ E R+ E E L +E N
Sbjct: 843 LLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKND------------ 890
Query: 576 KPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQ 635
QLQ+ + E + L++ A+E+ + S K+L +K+ + + + ++ NS+
Sbjct: 891 --LQLQVQS---ETENLMD----AEERCEGLIKS--KILLEAKVKELTERLEEEEEMNSE 939
Query: 636 LKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSK 674
L ++ L + + K+ L+ L KV KH +K
Sbjct: 940 LVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENK 978
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 113 bits (283), Expect = 5e-25
Identities = 155/650 (23%), Positives = 295/650 (45%), Gaps = 82/650 (12%)
Query: 68 KVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIE 127
K ++ ++ + + + A++ +QD L K+ A + ++K L+ A LE++
Sbjct: 712 KAEAGRVELELSMTKLRAEEASLQD---SLSKLSALNESLAQDKLDLNRLVAQLEEEKSA 768
Query: 128 LT-RTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRS 186
L R + + Q+ L L LE R E +R QE +E +L +
Sbjct: 769 LQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHE 828
Query: 187 LEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEK------YKLDIA 240
+ Q ++AQL +L E+E + E ++ +E +E + + + K +L A
Sbjct: 829 RSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAA 888
Query: 241 QLE-ENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENL 299
+ E L E+ + K++LE ++ + +Q+ L + + LE E + + E L
Sbjct: 889 EREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAK----ETL 944
Query: 300 NAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEE---MVKEK 356
E+ L+Q+ I+ QE+ L KEL L+Q E+E +SL ++ + +E+ + +EK
Sbjct: 945 TGELAGLRQQ-IIATQEKASLD-KELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREK 1002
Query: 357 NLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLL----EEKLKGKEAEL 412
EL+ +L Q+E+ E L+ +LE E + +EE+ L +E L E+E
Sbjct: 1003 EAAWRELEAERAQLQSQLQREQ--EELLARLEAEKEELSEEIAALQQERDEGLLLAESEK 1060
Query: 413 EKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYK---------------ALTASEIED 457
+++ + L EK SL ++ + E K ALT SE+ D
Sbjct: 1061 QQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALT-SELRD 1119
Query: 458 LKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVS 517
L+ + +E+AA A +A++V+ QE R L Q S L+E E +
Sbjct: 1120 LRAQ----REEAAAA--HAQEVRRL--------QEQARD-LGKQRDSCLREAEELRTQLR 1164
Query: 518 FLQKITD-LQNQLKQQEEDFRKQLEDEEGRKAEKE------NTTAELTEEINKWRLLYEE 570
L+ D L+ +L + + RK E +EGR+ +++ + E +E R EE
Sbjct: 1165 LLEDARDGLRRELLEAQ---RKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEE 1221
Query: 571 LYNKTKPFQLQLDAFEV------EKQALLNE-HGAAQEQLNKIRDSY-----AKLLGHQN 618
L + K + + + ++ +K ALL E A ++ ++R ++L +
Sbjct: 1222 LRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRE 1281
Query: 619 LKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIK 668
L++ + + L EN++L E+++L+ +LA +++E +E + LG++
Sbjct: 1282 LQELRRQMKMLDSENTRLGRELAELQGRLALGERAE---KESRRETLGLR 1328
Score = 90.1 bits (222), Expect = 6e-18
Identities = 134/613 (21%), Positives = 267/613 (43%), Gaps = 71/613 (11%)
Query: 42 QRFKQQKESKQNLNVDKDTTLPASARKVKS-SESKIRVLLQERGAQ------DRRIQDLE 94
+R ++KE+ + L A+ R+ ++ SE R+ L++ + R++ LE
Sbjct: 865 ERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLE 924
Query: 95 TELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLE 154
E++EA A L K +L+ A L +Q+I L K +++ +
Sbjct: 925 ARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKE------------LMAQK 972
Query: 155 LMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSL-EESQGKIAQLEGKLVSIEKEKIDEKS 213
L++ + + +R A E +LQ + + E + + AQL+ +L E+E++ +
Sbjct: 973 LVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQR-EQEELLARL 1031
Query: 214 ETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQS----LEENIVILSK 269
E EK E + E A Q L +A+ E+ + LSLK+S L E ++
Sbjct: 1032 EAEK--EELSEEIAALQQERDEGLLLAESEKQ------QALSLKESEKTALSEKLMGTRH 1083
Query: 270 QVEDLNVKCQLLEKEKEDHVNRNREHNENLNA---EMQNLK----QKFILEQQEREKLQQ 322
+ ++++ +E++K D +R + +NA E+++L+ + QE +LQ+
Sbjct: 1084 SLATISLE---MERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQE 1140
Query: 323 KELQI----DSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEE 378
+ + DS L++ +EL + L +L + ++ + L E + K + + Q++E
Sbjct: 1141 QARDLGKQRDSCLREAEELRTQL--RLLEDARDGLR-RELLEAQRKLRESQEGREVQRQE 1197
Query: 379 QAERLVKQLEEEAKSRA------EELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDS 432
E L + L E AK R EEL+ +K + + L+ ++ Q LL+E +
Sbjct: 1198 AGE-LRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTA 1256
Query: 433 MVQSLEDVTA---QFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESS 489
+ + ++ + E + E+++L+ + L + + G+ ++Q ++ E +
Sbjct: 1257 VGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERA 1316
Query: 490 NQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAE 549
+E R L L+ + E ++ + Q++ Q +L++QE +FR + G E
Sbjct: 1317 EKESRRETLGLRQRLLKGEASLEVMR----QELQVAQRKLQEQEGEFRTRERRLLGSLEE 1372
Query: 550 KENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNE-------HGAAQEQ 602
T + + L E + L+L A E Q L E AA+ Q
Sbjct: 1373 ARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQ 1432
Query: 603 LNKIRDSYAKLLG 615
L +R + + LG
Sbjct: 1433 LGGLRSALRRGLG 1445
Score = 85.5 bits (210), Expect = 2e-16
Identities = 145/684 (21%), Positives = 295/684 (43%), Gaps = 107/684 (15%)
Query: 56 VDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLS 115
V ++ + P S + ++E + LQE Q L+ EL ++E L + E+ L+
Sbjct: 55 VTRNLSQPESPVLLPATEMASLLSLQEEN------QLLQQELSRVEDLLAQSRAERDELA 108
Query: 116 ANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMK-LRNKRETKMRGMMAKQE 174
+ ++L + R L+ E + L S+EL + L+ ++ + R + A QE
Sbjct: 109 IKYNAVSERLEQALR----LEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQE 164
Query: 175 GMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKL----LEYIEEISCASD 230
G + + Q+ QR QGKI Q + + +E++ ++ E E+ E+ +++ A
Sbjct: 165 GQQRQAQLVQRL----QGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALI 220
Query: 231 QVEKYK---LDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKED 287
++E+ + +AQ+ L+E+ D+ S Q+L E+I ++V + +C+ KE E
Sbjct: 221 RLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDI----RKVTNDWTRCR---KELEH 273
Query: 288 HVNRNREHNENLNAEMQNLKQKFILEQQ----------------EREKLQ---------- 321
R E+ NA N + +L + ER+ LQ
Sbjct: 274 REAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSR 333
Query: 322 --------------QKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL 367
E + ++ L+++ L + L ++L ++++++EK+L +++++ L
Sbjct: 334 AVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQL---RDKVLREKDLAQQQMQSDL 390
Query: 368 DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA-ELEKSSAAHTQATLLL 426
D+ D L + + VK+LE++ + + K L EKL+ E+ L++ +A T+ L
Sbjct: 391 DKAD-LSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGL 449
Query: 427 QEKYDSMVQSLEDVTAQFESYKALTASE---------IEDLKLENSSLQEKAAKAGKNAE 477
Q+ + Q+ V + ES L+ SE + L + + + + G+
Sbjct: 450 QQTLRDLAQA---VLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRS 506
Query: 478 DVQHQILA-TESSNQEYVRMLL---DLQTKSALKETEIKEITVSFLQK-ITDLQNQLKQQ 532
+ A ++SS + L LQ + E + + L+K ++D +++ +
Sbjct: 507 PRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRAL 566
Query: 533 EEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQL---QLDAFEVEK 589
EE ++ + +G E+ E+ + LL E N Q+ Q + E+
Sbjct: 567 EEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQER 626
Query: 590 QALLNEHGAAQEQLNKIRDSYAK---------LLGHQNLKQKIKHVVKLKDENSQLKSEV 640
+ L AAQE+L + RD + + L++ + + +L+ + S L E+
Sbjct: 627 EKL----QAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKEL 682
Query: 641 SKLRCQLAKKKQSETKLQEELNKV 664
++R L++ LQ E +V
Sbjct: 683 VEVREALSRATLQRDMLQAEKAEV 706
Score = 78.2 bits (191), Expect = 2e-14
Identities = 130/637 (20%), Positives = 263/637 (41%), Gaps = 78/637 (12%)
Query: 49 ESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAAL 108
ES+ ++K L A + + + +VL ++ AQ Q ++++L+K A L+A +
Sbjct: 350 ESRAEAALEKQALLQAQLEE----QLRDKVLREKDLAQ----QQMQSDLDK--ADLSARV 399
Query: 109 REKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRG 168
T L LEKQ +E + N+ L K + + +LE ++T
Sbjct: 400 ---TELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDL 456
Query: 169 MMAKQEGMEMKLQVT--QRSLEESQGKIAQLEGKLVSIEKEKIDE------KSETEKLLE 220
A E +Q++ +R+ + S G + L G+ + +
Sbjct: 457 AQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACS 516
Query: 221 YIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSL---EENIVILSKQVEDLNVK 277
++ + K +L + + + D + +L++ L E L +Q++ L K
Sbjct: 517 DSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDK 576
Query: 278 CQLLEKEKED---HVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQE 334
+ ED V R R NE L+ E NL + QQ+ E+L+Q+
Sbjct: 577 TDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQER---------- 626
Query: 335 KELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSR 394
+KL + QEE+ ++++ EEE + + + +++++ E++ R ++QLE +
Sbjct: 627 --------EKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVL 678
Query: 395 AEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASE 454
A+EL + E L S A Q +L EK + + + E ++T
Sbjct: 679 AKELVEVREAL----------SRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLR 728
Query: 455 IEDLKLEN-----SSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKET 509
E+ L++ S+L E A+ + + Q+ +S+ Q R T + ++
Sbjct: 729 AEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQE 788
Query: 510 EIKEITVSFLQKITDLQNQLK---QQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRL 566
++E+ + L+ L+ Q +E +QL +++ + A+L+ +++
Sbjct: 789 RLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGRE- 847
Query: 567 LYEELYNKTKPFQLQLDAFE---VEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKI 623
+EL + Q Q++A E EK+AL EH QL + + +
Sbjct: 848 --QELEQARREAQRQVEALERAAREKEALAKEHAGLAVQL---------VAAEREGRTLS 896
Query: 624 KHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEE 660
+ +L+ E L+ + +++ QLA+ + +L+ E
Sbjct: 897 EEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAE 933
Score = 70.1 bits (170), Expect = 7e-12
Identities = 105/529 (19%), Positives = 225/529 (42%), Gaps = 38/529 (7%)
Query: 16 GCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSE-- 73
G A SP + D+ E ++G + + F Q+ S Q + T A R++ E
Sbjct: 1492 GPATSPASPDLDP-EAVRGAL-----REFLQELRSAQRERDELRTQTSALNRQLAEMEAE 1545
Query: 74 -----SKIRVLL-------QERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATL 121
S+ R L + R + D R+ ++ EL E + + RE+ + ATL
Sbjct: 1546 RDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATL 1605
Query: 122 EKQLIELTRTNELLKSKFSE-NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKL 180
E+ L + K S+ N+ L L ++ + E++ + ++ +E +L
Sbjct: 1606 ERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGEL 1665
Query: 181 QVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIA 240
Q ++ L + + + L+ ++ S++++ D + + L +E ++ A +VE+ + +
Sbjct: 1666 QRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALR 1725
Query: 241 QLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE---DHVNRNREHNE 297
L E + + S + + L K + Q+L++ + ++ R+ +
Sbjct: 1726 DKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSS 1785
Query: 298 NLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKN 357
+L ++Q L+ + + +R + + + Q+ +L+Q +E ++ + Q+ E+
Sbjct: 1786 SLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQD----ERR 1841
Query: 358 LFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEEL-KLLEEKLKGKE------A 410
L +E L L +L+ ++ + ER +LE++ + L K+ EKL+ E A
Sbjct: 1842 LLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSA 1901
Query: 411 ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAA 470
E + T A L L E +Q LE E + E+ D + + LQ++
Sbjct: 1902 EKGRLDRTLTGAELELAEA-QRQIQQLEAQVVVLEQSHSPAQLEV-DAQQQQLELQQEVE 1959
Query: 471 KAGKNAEDVQHQILATESSNQEYVRMLLD-LQTKSALKETEIKEITVSF 518
+ + + A E ++++ VR L + + T + E++ + F
Sbjct: 1960 RLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSAPF 2008
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 112 bits (280), Expect = 1e-24
Identities = 130/689 (18%), Positives = 289/689 (41%), Gaps = 69/689 (10%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELE 98
+K Q +QQ+ L D L + ++++ ++++ + Q + +++ L TE+
Sbjct: 114 EKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIA 173
Query: 99 KMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKL 158
++++ + + + L ++L + + LK++ + +++ +L EL+++
Sbjct: 174 DIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQV 233
Query: 159 RNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKL 218
+ + + E ++ + + Q S+ I+QL +L +E E +KL
Sbjct: 234 QTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKL 293
Query: 219 LEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKC 278
+ E++ + + + L Q L+EK++E K++++ + + L +
Sbjct: 294 KSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRL 353
Query: 279 QLLE----------KEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQID 328
E EK + + +E + + Q+LK +F QQ+RE+ +Q LQ+
Sbjct: 354 SASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQ 413
Query: 329 SLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLE 388
S + Q LH KL + ++ + +E+ + + ++L +Q+ + + +LE
Sbjct: 414 SEINQ-------LHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLE 466
Query: 389 EEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYK 448
E+ K + L+ +L + + ++ A T L+E + + Q L + + + +
Sbjct: 467 EQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQ 526
Query: 449 ALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKE 508
L A + EN SL E K ED+ +I A E +L LQ K+ +
Sbjct: 527 NLEA--LLQKSKENISLLE------KEREDLYAKIQAGEGE----TAVLNQLQEKNHTLQ 574
Query: 509 TEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLY 568
++ ++T +K+ + KQ +E+ Q+++++ ++ L +N+
Sbjct: 575 EQVTQLT----EKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQL 630
Query: 569 EELYNKTKPFQLQL----------DAFEVEKQALLNEH--------GAAQEQLNKIRDSY 610
E K +Q+ +A + ++A L H Q++LNKI
Sbjct: 631 NESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQL 690
Query: 611 ----AKLLGHQ--------NLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQS----- 653
AKL Q +LK+ + + L+ + +L+ ++ KL + K S
Sbjct: 691 DQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQAL 750
Query: 654 -ETKLQEELNKVLGIKHFDPSKAFHHESK 681
+ + Q +LN L ++ + SK E +
Sbjct: 751 QDLQQQRQLNTDLELRATELSKQLEMEKE 779
Score = 106 bits (265), Expect = 6e-23
Identities = 136/614 (22%), Positives = 266/614 (43%), Gaps = 77/614 (12%)
Query: 66 ARKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQL 125
+ ++K K + L Q+ D + D EL+ +E +L A E ++ E++
Sbjct: 106 SEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKA 165
Query: 126 IELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGM--EMKLQVT 183
+L +KSK+ E +++LR + ++ T++ + K+ + ++K ++
Sbjct: 166 AQLATEIADIKSKYDE---ERSLR-------EAAEQKVTRLTEELNKEATVIQDLKTELL 215
Query: 184 QRSLEESQGKIAQLEGKLVSI----EKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDI 239
QR E +A L+ +LV + + ++ + E+EKL + +++ Q + I
Sbjct: 216 QRPGIED---VAVLKKELVQVQTLMDNMTLERERESEKLKDECKKL---QSQYASSEATI 269
Query: 240 AQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLE----KEKEDHVNRNREH 295
+QL L + E+ Q L++ L V +L K Q L K+++D+ +H
Sbjct: 270 SQLRSELAKGPQEVAVYVQELQK----LKSSVNELTQKNQTLTENLLKKEQDYTKLEEKH 325
Query: 296 NENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKE 355
NE +++ +K I + L QK+L L + +SLH+ E+
Sbjct: 326 NE------ESVSKKNI-----QATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEAT 374
Query: 356 KNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKS 415
+ L +EEL + + L+ + +Q ++ ++ E+ E+ L KL E +L ++
Sbjct: 375 QKL-KEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEA 433
Query: 416 SAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKN 475
+ L EK Q ++ DL+L+ S L+E+ + N
Sbjct: 434 HGRLKEQRQLSSEKLMDKEQ------------------QVADLQLKLSRLEEQLKEKVTN 475
Query: 476 AEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSF---LQKITDLQNQLKQQ 532
+ ++QHQ+ T+ +QE + K + +++++ QKI +L+ L++
Sbjct: 476 STELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKS 535
Query: 533 EED---FRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEK 589
+E+ K+ ED + E TA L + K L E++ T+ + Q E K
Sbjct: 536 KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQ---SESHK 592
Query: 590 QALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAK 649
QA N H QEQ +R + ++L + V +L + ++ K +VS+L Q+
Sbjct: 593 QAQENLHDQVQEQKAHLRAAQDRVLSLET------SVNELNSQLNESKEKVSQLDIQI-- 644
Query: 650 KKQSETKLQEELNK 663
K ++E L E K
Sbjct: 645 KAKTELLLSAEAAK 658
Score = 102 bits (253), Expect = 2e-21
Identities = 145/663 (21%), Positives = 294/663 (44%), Gaps = 87/663 (13%)
Query: 46 QQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQER-GAQDRRIQDLETELEKMEARL 104
++K S+ ++ + T L SA K+++ R LQ +QD + EL K+ +L
Sbjct: 634 KEKVSQLDIQIKAKTELLLSAEAAKTAQ---RADLQNHLDTAQNALQDKQQELNKITTQL 690
Query: 105 NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSE-NGNQKNLRILSLELMKLRNKRE 163
+ + + + LE L E L+ K E G K L SLE+ +
Sbjct: 691 DQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEV------KA 744
Query: 164 TKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIE 223
+K + + Q+ ++ + R+ E S+ QLE + + ++D + ++E L +
Sbjct: 745 SKEQALQDLQQQRQLNTDLELRATELSK----QLEMEKEIVSSTRLDLQKKSEALESIKQ 800
Query: 224 EISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK 283
+++ ++ + K D L + K +++E+ + Q+ + + + E L + ++
Sbjct: 801 KLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK- 859
Query: 284 EKEDHVNRNREHNENLNAEMQNLKQK-----FILEQQEREKLQQKELQIDSLLQQEKELS 338
D +++ + +N +E + QK LE+ +E Q ++Q+++ L+++KEL
Sbjct: 860 ---DKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELK 916
Query: 339 SSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLE---------- 388
SL KEK E Q EL+ +Q++ QA+ +KQ E
Sbjct: 917 KSLE-----------KEK----EASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNI 961
Query: 389 -------EEAKSRAE----ELKL-------LEEKLKGKEAELEKSSAAHTQATLLLQEKY 430
E+ K + E ELK+ LE KL+ + + + AA + +LQ Y
Sbjct: 962 NELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNY 1021
Query: 431 DSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSN 490
+ ++ + + + F ++ + +DLK S++EK + A ++ ++QI
Sbjct: 1022 EKSQETFKQLQSDFYGRESELLATRQDLK----SVEEKLSLAQEDLISNRNQIGNQNKLI 1077
Query: 491 QEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDF---RKQLEDEEGRK 547
QE L+ SA KE +++E + + D+Q + +E++ + +L + E K
Sbjct: 1078 QELKTAKATLEQDSAKKEQQLQE----RCKALQDIQKEKSLKEKELVNEKSKLAEIEEIK 1133
Query: 548 AEKENTTAELTEEINKWRL-LYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKI 606
+E +L EE+ +L +E+ N QL + ++E Q + AA EQ +
Sbjct: 1134 CRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQ-KLELQGKADSLKAAVEQEKRN 1192
Query: 607 RDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEE---LNK 663
+ ++L Q K++ + + ++ ++L SE+ + + K +++E KL + LN+
Sbjct: 1193 Q----QILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNE 1248
Query: 664 VLG 666
LG
Sbjct: 1249 NLG 1251
Score = 87.8 bits (216), Expect = 3e-17
Identities = 116/497 (23%), Positives = 205/497 (41%), Gaps = 73/497 (14%)
Query: 27 KTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQ 86
KT + LK + Q K+QKE K++L +K+ +
Sbjct: 892 KTCKELKHQLQVQMENTLKEQKELKKSLEKEKEAS------------------------- 926
Query: 87 DRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQK 146
L+ EL M+ +L A L+ + EL +++E K + Q
Sbjct: 927 ----HQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIE--ALQG 980
Query: 147 NLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEK 206
L+I L+ +L NK + ++ + + K+ V Q + E+SQ QL+ E
Sbjct: 981 ELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRES 1040
Query: 207 EKI----DEKSETEKLLEYIEEISCASDQV-------EKYKLDIAQLEENLKEKNDEI-- 253
E + D KS EKL E++ +Q+ ++ K A LE++ +K ++
Sbjct: 1041 ELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQE 1100
Query: 254 -------LSLKQSLEENIVI--LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQ 304
+ ++SL+E ++ SK E +KC+ EKE + H E+
Sbjct: 1101 RCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQ-EKEITKLNEELKSHKLESIKEIT 1159
Query: 305 NLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELK 364
NLK L Q++ +LQ K + + ++QEK L ++ +EE+ KE E +L
Sbjct: 1160 NLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLH 1219
Query: 365 QTLDELDKLQQKEEQAER--------------LVKQLEEEAKSRAEELKLLEEKLKGKEA 410
+ E + +K E+ E VK+ + ++ R EL+ + L+G+ A
Sbjct: 1220 SEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIA 1279
Query: 411 ELEKSSAAHTQATLLLQE---KYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQE 467
LE + + L E K + ++ L+ + + T + +++L EN SLQ
Sbjct: 1280 VLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQI 1339
Query: 468 KAAKA--GKNAEDVQHQ 482
K +A K AED + Q
Sbjct: 1340 KHTQALNRKWAEDNEVQ 1356
Score = 72.4 bits (176), Expect = 1e-12
Identities = 112/544 (20%), Positives = 224/544 (41%), Gaps = 73/544 (13%)
Query: 175 GMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEK 234
G E L + + + + ++ L+ L + + K E EK ++ + V
Sbjct: 73 GGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTD 132
Query: 235 YKLDIAQLEENLKEKNDEILSLKQS---LEENIVILSKQVEDLNVKCQLLEKEKEDHVNR 291
++ LE+ L+E E ++KQ E+ L+ ++ D+ K +E +
Sbjct: 133 SSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQK 192
Query: 292 NREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEE 351
E LN K+ +++ + E LQ+ ++ ++L++E +L +
Sbjct: 193 VTRLTEELN------KEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTL-------MDN 239
Query: 352 MVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLE---EKLKGK 408
M E+ E+LK DE KLQ + +E + QL E +E+ + +KLK
Sbjct: 240 MTLERERESEKLK---DECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSS 296
Query: 409 EAELEKSSAAHTQATL-------LLQEKYDSMVQSLEDVTAQFESYKALTASEIED-LKL 460
EL + + T+ L L+EK++ S +++ A K L +++ L
Sbjct: 297 VNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQ-KDLDCQQLQSRLSA 355
Query: 461 ENSSLQE---KAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKE-------TE 510
+SL + ++ G+ + ++ ++ E+ Q LQ + KE +E
Sbjct: 356 SETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSE 415
Query: 511 IKEITVSFLQ---KITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLL 567
I ++ L+ ++ + +LK+Q + ++L D+E + A+ + + L E++ +
Sbjct: 416 INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN 475
Query: 568 YEEL---YNKTKPFQLQLDAFEVEKQALLNEHGAAQEQ-LNKIRDSYAKLLGHQNLKQKI 623
EL +KTK + A + A L E EQ L +I D K+ + L QK
Sbjct: 476 STELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKS 535
Query: 624 KHVV-------------------------KLKDENSQLKSEVSKLRCQLAKKKQSETKLQ 658
K + +L+++N L+ +V++L +L + +S + Q
Sbjct: 536 KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595
Query: 659 EELN 662
E L+
Sbjct: 596 ENLH 599
Score = 68.2 bits (165), Expect = 3e-11
Identities = 92/371 (24%), Positives = 164/371 (44%), Gaps = 60/371 (16%)
Query: 328 DSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQL 387
+S L +++ + L Q++ Q + KE+ + EELK+ L++ LQQ+E + + LV
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASL-KEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDS 133
Query: 388 EEEAKSRAEELKLLEEK---LKGKEAELEKSSAAHTQATLLLQEKYD---SMVQSLEDVT 441
E +S ++L+ + + +K + E+ +A ++ KYD S+ ++ E
Sbjct: 134 SAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKV 193
Query: 442 AQFESYKALTASEIEDLKLENSSLQ----EKAAKAGKNAEDVQ----HQILATESSNQEY 493
+ A+ I+DLK E LQ E A K VQ + L E +++
Sbjct: 194 TRLTEELNKEATVIQDLKTE--LLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKL 251
Query: 494 VRMLLDLQTKSALKETEIKE-------------ITVSFLQKITDLQNQLKQQEEDFRKQL 540
LQ++ A E I + + V LQK+ N+L Q+ + + L
Sbjct: 252 KDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENL 311
Query: 541 EDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQ 600
+KE +L E+ N EE +K K Q L +++ Q L + A++
Sbjct: 312 -------LKKEQDYTKLEEKHN------EESVSK-KNIQATLHQKDLDCQQLQSRLSASE 357
Query: 601 EQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQ-------LKSEVSKLRCQLAKKKQS 653
L++I H L +K + KLK+E S+ LK+E +L+ Q +K+Q
Sbjct: 358 TSLHRI---------HVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQH 408
Query: 654 ETKLQEELNKV 664
+LQ E+N++
Sbjct: 409 GLQLQSEINQL 419
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 111 bits (278), Expect = 2e-24
Identities = 152/671 (22%), Positives = 284/671 (42%), Gaps = 105/671 (15%)
Query: 92 DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRT-NELLKSKFSENGNQKNLRI 150
+ E E+ M+ E A LE++++ L + N+L SE + +
Sbjct: 847 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEE 906
Query: 151 LSLELMKLRNKRETKMRGMMAK---QEGMEMKLQVTQRSLE----ESQGKIAQLEGKLVS 203
+L+K + + E K++ + + +E + +L +R LE E + I LE L
Sbjct: 907 RCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 966
Query: 204 IEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEEN 263
+EKEK +++ + L E E++ + + K + L+E ++ D++ Q+ E+
Sbjct: 967 VEKEKHATENKVKNLTE---EMAGLDETIAKLSKEKKALQETHQQTLDDL----QAEEDK 1019
Query: 264 IVILSK-------QVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQE 316
+ IL+K QV+DL + +K + D R+ +L ++ +QQ
Sbjct: 1020 VNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQL 1079
Query: 317 REKLQQKELQIDSLL---QQEKELSSSLHQKLCSFQ-------EEMVKEKNLFEEELKQT 366
EKL++KE +I +L+ + E+ + L +K+ Q EE+ E+ + KQ
Sbjct: 1080 DEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQR 1139
Query: 367 LD---ELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQAT 423
D EL+++ ++ E+A E K R E + L +LE+++ H
Sbjct: 1140 SDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRR-------DLEEATLQHEAMV 1192
Query: 424 LLLQEKY-DSM------VQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNA 476
L++K+ DSM + +L+ V + E K+ E +DL ++ + K
Sbjct: 1193 AALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMC 1252
Query: 477 EDVQHQILATESSNQEYVRMLLDLQTKSALKETEI---------KEITVSFL-------- 519
++ Q+ ++ +E R++ DL + A +TE K+ VS L
Sbjct: 1253 RSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAST 1312
Query: 520 QKITDLQNQLKQQEED-----------------FRKQLEDEEGRKAEKENTTAELTEEIN 562
Q+I +L++QL+++ + R+Q E+E+ KAE + ++ E+
Sbjct: 1313 QQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA 1372
Query: 563 KWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQK 622
+WR YE T Q + + E K+ L A+E + + AK + KQ+
Sbjct: 1373 QWRTKYE-----TDAIQ-RTEELEEAKKKLAQRLQEAEEHVEAVN---AKCASLEKTKQR 1423
Query: 623 IKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLG---IKHFDPSKAFHHE 679
+++ V E+ L E S C KK Q +KVL K+ +
Sbjct: 1424 LQNEV----EDLMLDVERSNAACAALDKK------QRNFDKVLSEWKQKYEETQAELEAS 1473
Query: 680 SKENFALKTPL 690
KE+ +L T L
Sbjct: 1474 QKESRSLSTEL 1484
Score = 111 bits (277), Expect = 3e-24
Identities = 142/680 (20%), Positives = 301/680 (44%), Gaps = 65/680 (9%)
Query: 30 EVLKGPVSFQ-KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDR 88
+++K + + K + ++ E ++ +N + L A RK++ S+++ +
Sbjct: 910 QLIKNKIQLEAKIKEVTERAEEEEEINAE----LTAKKRKLEDECSELK----------K 955
Query: 89 RIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSE-----NG 143
I DLE L K+E +A + +L+ A L++ + +L++ + L+ +
Sbjct: 956 DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQA 1015
Query: 144 NQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVS 203
+ + IL+ KL + + + G + +++ + M L+ +R L E K+AQ +
Sbjct: 1016 EEDKVNILTKAKTKLEQQVD-DLEGSLEQEKKLRMDLERAKRKL-EGDLKLAQESTMDME 1073
Query: 204 IEKEKIDEKSETEK-----LLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQ 258
+K+++DEK E ++ L+ IE+ Q++K I +L+ ++E +EI + +
Sbjct: 1074 NDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQK---KIKELQARIEELGEEIEAERA 1130
Query: 259 S---LEENIVILSKQVEDLNVKCQ----------LLEKEKEDHVNRNREHNENLNAEMQN 305
S E+ LS+++E+++ + + L K++E + R E A +Q+
Sbjct: 1131 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLE--EATLQH 1188
Query: 306 LKQKFILEQQEREKLQQKELQIDSL------LQQEKELSSSLHQKLCSFQEEMVKEKNLF 359
L ++ + + + QID+L L++EK L S E + K K
Sbjct: 1189 EAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNL 1248
Query: 360 EEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA---ELEKSS 416
E+ + D++ +L+ KEE+ +RL+ L + E +L K+A +L +S
Sbjct: 1249 EKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSK 1308
Query: 417 AAHTQATLLLQEKYDSMVQSLEDVTAQFESYK---ALTASEIEDLKLENSSLQEKAAKAG 473
A TQ L+ + + ++ + +S + L + E+ + + LQ +KA
Sbjct: 1309 QASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKA- 1367
Query: 474 KNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQ---NQLK 530
N+E Q + E+ + L + + K A + E +E + K L+ +L+
Sbjct: 1368 -NSEVAQWR-TKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQ 1425
Query: 531 QQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQ 590
+ ED +E A + + +++W+ YEE + + Q + + E
Sbjct: 1426 NEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELF 1485
Query: 591 ALLNEHGAAQEQLNKIRDSYAKLLGH-QNLKQKIKHVVKLKDENSQLKSEVSKLRCQL-A 648
+ N + + +QL +R L +L ++I K E ++K +V + +C++ A
Sbjct: 1486 KVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQA 1545
Query: 649 KKKQSETKLQEELNKVLGIK 668
+++E L+ E K+L I+
Sbjct: 1546 ALEEAEASLEHEEGKILRIQ 1565
Score = 97.4 bits (241), Expect = 4e-20
Identities = 146/672 (21%), Positives = 283/672 (42%), Gaps = 80/672 (11%)
Query: 45 KQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARL 104
K +ES ++ DK K++ E +I L+ + + L+ ++++++AR+
Sbjct: 1063 KLAQESTMDMENDKQQL----DEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARI 1118
Query: 105 NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET 164
E + A+ A EKQ +L+R E + + E G + ++ EL K R
Sbjct: 1119 EELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQV---ELNKKREAEFQ 1175
Query: 165 KMRGMM----AKQEGMEMKLQVTQR-SLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLL 219
K+R + + E M L+ S+ E +I L+ +EKEK + K ET+ L
Sbjct: 1176 KLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLS 1235
Query: 220 EYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQ 279
E IS A +EK + LK K +E L L L + + + +
Sbjct: 1236 SNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLD 1295
Query: 280 LLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREK------LQQKELQIDSLLQQ 333
EK+ V++ + +++ LK + LE++ + K LQ D L +Q
Sbjct: 1296 ----EKDALVSQLSRSKQASTQQIEELKHQ--LEEETKAKNALAHALQSSRHDCDLLREQ 1349
Query: 334 ---EKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD----KLQQKEEQAERLVKQ 386
E+E + L + L E+ + + +E + Q +EL+ KL Q+ ++AE V+
Sbjct: 1350 YEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEA 1409
Query: 387 LEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFES 446
+ + S + + L+ +++ ++E+S+AA D ++ + V ++++
Sbjct: 1410 VNAKCASLEKTKQRLQNEVEDLMLDVERSNAACA--------ALDKKQRNFDKVLSEWKQ 1461
Query: 447 YKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSAL 506
T +E+E + E+ SL + K E+ Q+ N+ + + DL + A
Sbjct: 1462 KYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAE 1521
Query: 507 KETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGR-----------KAEKENTTA 555
+I E+ +++ + +++ E+ LE EEG+ K+E + A
Sbjct: 1522 GGKQIHELE-KIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIA 1580
Query: 556 ELTEEI-----NKWRLLYEELYNKTKPFQLQLDAFEVEK--QALLNE--------HGAAQ 600
E EEI N R++ + + DA V+K + LNE + A
Sbjct: 1581 EKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAA 1640
Query: 601 EQLNKIRDSYA-----------KLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAK 649
E L R++ L G ++LK+++ V + + L++E+ +L L +
Sbjct: 1641 ESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVER---RANLLQAEIEELWATLEQ 1697
Query: 650 KKQSETKLQEEL 661
++S ++EL
Sbjct: 1698 TERSRKIAEQEL 1709
Score = 88.2 bits (217), Expect = 2e-17
Identities = 133/642 (20%), Positives = 277/642 (43%), Gaps = 111/642 (17%)
Query: 42 QRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKME 101
QR ++ +E+K+ L A++++ +E + + + + ++ Q L+ E+E +
Sbjct: 1384 QRTEELEEAKKKL-----------AQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1432
Query: 102 ARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNK 161
+ + +L +K L E + E +++ +QK R LS EL K++N
Sbjct: 1433 LDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELE--ASQKESRSLSTELFKVKNV 1490
Query: 162 RET---KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKS---ET 215
E ++ + + + ++ ++ + E +I +LE +E+EK + ++ E
Sbjct: 1491 YEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEA 1550
Query: 216 EKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLN 275
E LE+ EE Q+E ++ ++++ + EK++EI LK++ +V + D
Sbjct: 1551 EASLEH-EEGKILRIQLELNQVK-SEVDRKIAEKDEEIDQLKRN-HTRVVETMQSTLDAE 1607
Query: 276 VKCQ----LLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLL 331
++ + ++K+ E +N E LN + + + + L++ +L +D L
Sbjct: 1608 IRSRNDALRVKKKMEGDLN---EMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDAL 1664
Query: 332 QQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEA 391
+ +++L L + + NL + E+++ L EQ ER K E+E
Sbjct: 1665 RGQEDLKEQL--------AIVERRANLLQAEIEELWATL-------EQTERSRKIAEQEL 1709
Query: 392 KSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALT 451
+E ++LL HTQ T L+ K + LE+ +Q +S
Sbjct: 1710 LDASERVQLL-----------------HTQNTSLINTK-----KKLENDVSQLQS----- 1742
Query: 452 ASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEI 511
E+E++ E+ + +EKA KA +A + ++ + ++ RM +L
Sbjct: 1743 --EVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL----------- 1789
Query: 512 KEITVSFLQKITDLQNQL-----KQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRL 566
E TV LQ D QL K+Q + ++ + EG ++ AE + + K
Sbjct: 1790 -EQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHER 1848
Query: 567 LYEELYNKTKP-------FQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNL 619
+EL +T+ Q +D + + ++ + A+EQ N +
Sbjct: 1849 RVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKF--------- 1899
Query: 620 KQKIKHVVKLKDENSQL-KSEVSKLRCQLAKKKQSETKLQEE 660
+K++H ++ +E + + +S+V+KLR K ++ TK+ E
Sbjct: 1900 -RKLQHELEEAEERADIAESQVNKLR---VKSREVHTKISAE 1937
Score = 61.6 bits (148), Expect = 2e-09
Identities = 83/435 (19%), Positives = 177/435 (40%), Gaps = 72/435 (16%)
Query: 28 TLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKI-RVLL---QER 83
T ++ +G + ++ K+Q E ++ + L + ++ E KI R+ L Q +
Sbjct: 1516 TEQIAEGGKQIHELEKIKKQVEQEK---CEIQAALEEAEASLEHEEGKILRIQLELNQVK 1572
Query: 84 GAQDRRIQDLETEL-----------EKMEARLNAALREKTSLSANNATLEKQL----IEL 128
DR+I + + E+ E M++ L+A +R + +E L I+L
Sbjct: 1573 SEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQL 1632
Query: 129 TRTNELLKSKFSENGN------------------QKNLRILSLELMKLRNKRETKMRGMM 170
N L N Q++L+ + + N + ++ +
Sbjct: 1633 NHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELW 1692
Query: 171 AKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI----S 226
A E E ++ ++ L ++ ++ L + S+ K +++ +L +EE+
Sbjct: 1693 ATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESR 1752
Query: 227 CASDQVEKYKLDIAQLEENLKEKND---EILSLKQSLEENIVILS--------------- 268
A ++ +K D A + E LK++ D + +K++LE+ + L
Sbjct: 1753 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGK 1812
Query: 269 KQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQID 328
KQ++ L + + LE E E+ RN E + L + +K+ +++R+ + + + +D
Sbjct: 1813 KQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVD 1872
Query: 329 SLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLE 388
L + K EE ++ N + ++ EL++ +++ + AE V +L
Sbjct: 1873 KLQAKVKSYKRQ--------AEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKL- 1923
Query: 389 EEAKSRAEELKLLEE 403
KSR K+ E
Sbjct: 1924 -RVKSREVHTKISAE 1937
Score = 47.8 bits (112), Expect = 4e-05
Identities = 65/326 (19%), Positives = 130/326 (39%), Gaps = 57/326 (17%)
Query: 376 KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 435
K + E+ + ++EE + +EL E K K E ++ L +Q + DS+
Sbjct: 844 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLAD 903
Query: 436 S-----------------LEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAED 478
+ +++VT + E + + A +L + L+++ ++ K+ +D
Sbjct: 904 AEERCEQLIKNKIQLEAKIKEVTERAEEEEEINA----ELTAKKRKLEDECSELKKDIDD 959
Query: 479 -------VQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQ----- 526
V+ + ATE+ + + L A E K + + Q + DLQ
Sbjct: 960 LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDK 1019
Query: 527 --------NQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPF 578
+L+QQ +D LE E+ + + E +L ++ + ++ N +
Sbjct: 1020 VNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQL 1079
Query: 579 QLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKS 638
+L+ E E L ++KI D A + L++KIK +L+ +L
Sbjct: 1080 DEKLEKKEFEISNL----------ISKIEDEQAVEI---QLQKKIK---ELQARIEELGE 1123
Query: 639 EVSKLRCQLAKKKQSETKLQEELNKV 664
E+ R AK ++ + L EL ++
Sbjct: 1124 EIEAERASRAKAEKQRSDLSRELEEI 1149
>gi|34577114 cytomatrix protein p110 [Homo sapiens]
Length = 957
Score = 111 bits (277), Expect = 3e-24
Identities = 161/718 (22%), Positives = 311/718 (43%), Gaps = 101/718 (14%)
Query: 69 VKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIEL 128
++ +E R L E Q + + L LE+ME R+ +K +L+A + +++K L+E+
Sbjct: 256 IELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIET---QKQTLNARDESIKK-LLEM 311
Query: 129 TRTNELLKSKFSENGNQKNLRILSLE--------LMKLRNKRETKMRGMMAKQEGME--- 177
++ L SK E+ N++ R+ E ++ + K +R + ++ ++
Sbjct: 312 LQSKGL-PSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEP 370
Query: 178 MKLQVTQRSLEESQGKIAQLEGKLVSIEKE----KIDEKSETEKLLEYIEEISCASDQVE 233
K + Q +E KIA LE + +E E K + TE E I++I +
Sbjct: 371 AKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSK 430
Query: 234 KYKLDIAQLEENLKEKNDEILSLKQSLE----------ENIVILSKQVEDLNVKCQLLE- 282
K I QL++ L +K E+L+L+ LE ++I +L + + + +L+
Sbjct: 431 FMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQT 490
Query: 283 ---------KEKEDHVNRNREHNENLNAEMQNLK-----QKFILEQQERE--KLQQKELQ 326
+EKE +N+ + ++L E L K +LE +ER+ LQ+K
Sbjct: 491 EVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIEN 550
Query: 327 IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQK-EEQAERLVK 385
+ L+ + + ++L ++ S Q + L++ L E +++ ++ +EQ ER +
Sbjct: 551 LQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALAT-LEEALSEKERIIERLKEQRERDDR 609
Query: 386 QLEEEAKSRAEELKLLEEKLKGKEAEL-EKSSAA-----HTQATLLLQEKYDSMVQSLED 439
+ EE +S +E K L+EK+ +AEL EK S+ H + K DS ++SLE
Sbjct: 610 ERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEI 669
Query: 440 VTAQFESY------KALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEY 493
Q + + A IED N ++ + K A + + ++
Sbjct: 670 AIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRL 729
Query: 494 VRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENT 553
+ +L +++ + K+ +I E+ L+ + D ++ + + +QLE ++ + +E
Sbjct: 730 LEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHN--QQLEKKKNAQLLEEVR 787
Query: 554 TAELTEEINKWRLLYEELYNKTKPFQLQLDAFE----------VEKQA-LLNEHGAAQEQ 602
E + N L EEL N + + +LDA + EK+A L N ++Q
Sbjct: 788 RREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQ 847
Query: 603 LNKI--------------RDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLA 648
L +I +D+ LL K+K K ++E LK E +L QL
Sbjct: 848 LEEILEMKQEALLAAISEKDANIALLELSASKKK-----KTQEEVMALKREKDRLVHQLK 902
Query: 649 KKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQE 706
++ Q+ KL + ++D +H + ++P + ++N +P + E
Sbjct: 903 QQTQNRMKLMAD--------NYDDDHHHYHHHHHHHHHRSPGRSQHSNHRPSPDQDDE 952
Score = 91.3 bits (225), Expect = 3e-18
Identities = 136/618 (22%), Positives = 255/618 (41%), Gaps = 109/618 (17%)
Query: 121 LEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKL 180
L+ QL EL R N+LL+ + ++ S+ +K E K ++ K+E M
Sbjct: 150 LQAQLKELQRENDLLRKELDIKDSKLGS---SMNSIKTFWSPELKKERVLRKEEAARM-- 204
Query: 181 QVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIA 240
S+ + Q +++ E + + + + + ++ T++ L ++ + + E + +++
Sbjct: 205 -----SVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELT 259
Query: 241 QLEEN---LKEKND----EILSLKQSLEENIVILSKQVEDLNVKCQ----LLE------- 282
EEN L+ ++D E+ L+++LEE + + Q + LN + + LLE
Sbjct: 260 --EENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGL 317
Query: 283 --KEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQ-QKELQIDSLLQQEKELSS 339
K ED R R E AE Q + IL+Q+E+E + ++EL S LQ E +
Sbjct: 318 PSKSLEDDNERTRRMAE---AESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTK 374
Query: 340 SLHQ-------KLCSFQE---------EMVKEKNLFE-EELKQTLDELDKLQQKEEQAER 382
+L K+ S + +M+K + E+ ++ + +++ + + +
Sbjct: 375 ALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKT 434
Query: 383 LVKQLEEEAKSRAEELKLLEEKLKGKEAE----------LEKSSAAHTQATLLLQEKYDS 432
+ QL++E + EL L+ KL+ + L++S A Q +LQ + D+
Sbjct: 435 KIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDA 494
Query: 433 MVQSLEDV-------TAQFESY---KALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQ 482
+ LE+ T Q + K A EI D+K + K K E++Q Q
Sbjct: 495 LRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQ 554
Query: 483 ILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLED 542
+ + + LQT S+ +T + + + +K ++ +Q+E D R++LE+
Sbjct: 555 LRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEE 614
Query: 543 EEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQAL-LNEHGAAQE 601
E + E + +L E++N LQ + E E + L EH ++
Sbjct: 615 IESFRKENK----DLKEKVN----------------ALQAELTEKESSLIDLKEHASSLA 654
Query: 602 QLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEEL 661
RDS K L+ Q K E SKL QL K E +
Sbjct: 655 SAGLKRDSKLK---------------SLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNP 699
Query: 662 NKVLGIKHFDPSKAFHHE 679
IK D +++ +
Sbjct: 700 EFADQIKQLDKEASYYRD 717
Score = 63.5 bits (153), Expect = 6e-10
Identities = 100/520 (19%), Positives = 215/520 (41%), Gaps = 90/520 (17%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSES-------KIRVLLQERGAQDRRIQ 91
Q + K+ +K+ T + A +++ ES +++ L +E+G I+
Sbjct: 469 QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIR 528
Query: 92 DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRIL 151
D++ LE E ++N L+K++ L Q+ LR
Sbjct: 529 DMKDMLEVKERKIN--------------VLQKKIENL----------------QEQLRDK 558
Query: 152 SLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDE 211
+L L++ +++ + + L + +L E + I +L+ E+ + D+
Sbjct: 559 DKQLTNLKD----RVKSLQTDSSNTDTALATLEEALSEKERIIERLK------EQRERDD 608
Query: 212 KSETEKLLEYIEEISCASDQVEKYKLDIAQLEE---NLKEKNDEILSLKQSLEENIVILS 268
+ E++ + +E ++V + ++ + E +LKE + S + + L
Sbjct: 609 RERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLE 668
Query: 269 KQVEDLNVKCQLLEKE-KEDHVNRNREHNENLNAEM-QNLKQKFILEQQEREKLQQKELQ 326
+E +C LE + K+ H N E + +N E +KQ R++ + + +
Sbjct: 669 IAIEQKKEECSKLEAQLKKAH---NIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAE 725
Query: 327 IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 386
+D LL+ KE+ + E+ K+K + E L+ L L+ ++Q +++
Sbjct: 726 VDRLLEILKEVEN----------EKNDKDKKIAE------LESL-TLRHMKDQNKKVANL 768
Query: 387 LEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFES 446
+ + + +LLEE + +++ + S H Q + ++ +LE + ++
Sbjct: 769 KHNQQLEKKKNAQLLEEVRRREDSMADNSQ--HLQ--------IEELMNALEKTRQELDA 818
Query: 447 YKALTASEIEDLKLENSSLQEKAAKAGKNAEDV----QHQILATESSNQEYVRMLLDLQT 502
KA AS + L + + L + K E++ Q +LA S + +L
Sbjct: 819 TKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALL----E 874
Query: 503 KSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLED 542
SA K+ + +E ++ ++ L +QLKQQ ++ K + D
Sbjct: 875 LSASKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLMAD 914
Score = 52.4 bits (124), Expect = 1e-06
Identities = 55/282 (19%), Positives = 131/282 (46%), Gaps = 24/282 (8%)
Query: 26 VKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTL-PASARKVKSSESKIRVLLQERG 84
+K+LE+ + +K + K + + K+ N++ D+ + P A ++K + + E G
Sbjct: 664 LKSLEIA---IEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECG 720
Query: 85 ---AQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSE 141
A+ R+ ++ E+E + + + E SL+ + + + + + N+ L+ K
Sbjct: 721 KAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKK--- 777
Query: 142 NGNQKNLRILS----LELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQL 197
KN ++L E N + ++ +M E +L T+ L +Q +A+
Sbjct: 778 ----KNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEK 833
Query: 198 EGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEK-NDEILSL 256
E L ++ +I+ + + E++LE +E A+ + + + +L + K+K +E+++L
Sbjct: 834 EAHLANL---RIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMAL 890
Query: 257 KQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNEN 298
K+ + + L +Q + N + + +DH + + H+ +
Sbjct: 891 KREKDRLVHQLKQQTQ--NRMKLMADNYDDDHHHYHHHHHHH 930
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 110 bits (276), Expect = 3e-24
Identities = 131/634 (20%), Positives = 286/634 (45%), Gaps = 95/634 (14%)
Query: 59 DTTLPASARKVKSSESKIRVLLQERGAQDRRI-------QDLETELEKMEARLNAALREK 111
+ L A A + K ++ I L +ER A + ++L+ + K++ +L EK
Sbjct: 178 EQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEK 237
Query: 112 TSLSANNATLEKQL--IELTRTNELLKSKFSENGNQKNLRILSLELM----------KLR 159
+ + N L+++L +L + L+++ G K L+ +S +L +L
Sbjct: 238 SEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG--KELQSVSAKLQAQVEENELWNRLN 295
Query: 160 NKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEK---EKIDEKSETE 216
++E KM K + E K+Q + + E + KI + E K+ E+ EK ++ E
Sbjct: 296 QQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQE 355
Query: 217 KLL-EYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLN 275
+++ E E++ + + + + + + EE + EK ++I L++ + E I ++
Sbjct: 356 EMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQE----- 410
Query: 276 VKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKEL--QIDSLLQQ 333
EK +E+ R +E + A+M ++K I EQ+E+ + Q+K++ Q + + +Q
Sbjct: 411 ------EKRQEEEKIREQEKRQEQEAKMWRQEEK-IREQEEKIREQEKKMWRQEEKIHEQ 463
Query: 334 EK--ELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQA---ERLVKQLE 388
EK E Q+ QEE + E+ + ++ ++ +K++++EE+ E +++ E
Sbjct: 464 EKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQE 523
Query: 389 EEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYK 448
E+ + + E++ EEK++ +E + H Q + +EK Q ED
Sbjct: 524 EKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKR----QEQED--------- 570
Query: 449 ALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKE 508
+ + ++E+ K + E ++ Q E QE + + K ++E
Sbjct: 571 --------KMWRQEEKIREQEEKVWRQEEKIREQ----EEKRQEQEEKMWKQEEK--IRE 616
Query: 509 TEIKEITVSFLQKITDLQNQLKQQEEDFRKQLE---DEEGRKAEKENTTAELTEEINKWR 565
E +KI + + ++++QEE R+Q E ++E + E+E E E++ +
Sbjct: 617 QE---------EKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQE 667
Query: 566 LLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKH 625
E ++ + + + Q +++ + + QEQ K+ + K+ +
Sbjct: 668 ---ETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE------- 717
Query: 626 VVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 659
K++++ +++ + K+ Q + +Q E K+QE
Sbjct: 718 --KMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 100 bits (250), Expect = 4e-21
Identities = 135/660 (20%), Positives = 285/660 (43%), Gaps = 76/660 (11%)
Query: 48 KESKQNLNVDKDTTLPASAR----KVKSSESKIRVLLQERGAQDRRIQDLETELEKMEAR 103
K+ K N + +TT + K+S L +E AQ I+ L + +++
Sbjct: 86 KKKKINNGTNPETTTSGGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMA 145
Query: 104 LNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRE 163
L + L L +L + + L+ S QK K +
Sbjct: 146 LYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKK-------------KAD 192
Query: 164 TKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEK---------IDEKSE 214
+ + +++ + ++L + EE + K A+L+ KL +E EK + K E
Sbjct: 193 RYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLE 252
Query: 215 TEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDL 274
KLL +++ +D + K ++ + E+N+ L Q EE + +++++
Sbjct: 253 RAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEW 312
Query: 275 NVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQE 334
K Q E++ + + RE E + + + + +K +++ E + +KE + ++++
Sbjct: 313 EEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK----MRRQ 368
Query: 335 KELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEE--QAERLV----KQLE 388
+E+ +K+ QEEM+ EK EL++ + E +K++++EE Q E + K+ E
Sbjct: 369 EEMMWEKEEKMRR-QEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 427
Query: 389 EEAKSRAEELKLLEEKLKGKEAELE---KSSAAHTQATLLLQEKYDSMVQSLEDVTAQFE 445
+EAK +E K+ E++ K +E E + + H Q + +EK Q E++ Q E
Sbjct: 428 QEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKR----QEQEEMWRQEE 483
Query: 446 SYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSA 505
E E++ + + E+ K K E V Q E +E + + + K
Sbjct: 484 KIH-----EQEEIWRQKEKMHEQEEKIRKQEEKVWRQ----EEKIREQEEKIREQEEKMW 534
Query: 506 LKETEIKEITVSFLQ--------------KITDLQNQLKQQEEDFRKQLEDEEGRKAEK- 550
+E +I+E + + K + ++++ +QEE R+Q E++ R+ EK
Sbjct: 535 RQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQ-EEKVWRQEEKI 593
Query: 551 -ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDS 609
E +E W+ E++ + + Q Q + +++ + + QEQ K+ +
Sbjct: 594 REQEEKRQEQEEKMWK-QEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQ 652
Query: 610 YAKLLGHQNLKQKIKHVV-----KLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKV 664
K+ + Q+ + + K++++ +++ + K+R Q ++ E K+ E+ K+
Sbjct: 653 EEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM 712
Score = 75.1 bits (183), Expect = 2e-13
Identities = 92/461 (19%), Positives = 207/461 (44%), Gaps = 76/461 (16%)
Query: 43 RFKQQKESKQNLNVDK----DTTLPASARKVKSSESKIRV----------LLQERGAQDR 88
R QQ+E K +K + + K++ E KIR ++ E+ + R
Sbjct: 293 RLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMR 352
Query: 89 RIQDLETELEKMEARLNAALREKTSLSANNATL----EKQLIELT-RTNELLKSKFSENG 143
R +++ E E+ R + EK + E+++ EL + +E K + E
Sbjct: 353 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEK 412
Query: 144 NQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVS 203
Q+ +I E R ++E KM K E K++ ++ + + KI + E K+
Sbjct: 413 RQEEEKIREQEK---RQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQE-KIRE 468
Query: 204 IEK-----------EKIDEKSET----EKLLEYIEEISCASDQVEKYKLDIAQLEENLKE 248
EK EKI E+ E EK+ E E+I ++V + + I + EE ++E
Sbjct: 469 EEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIRE 528
Query: 249 KNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK----------------------- 285
+ +++ ++ + E + ++ E ++ + ++ E+EK
Sbjct: 529 QEEKMWRQEEKIREQEEMWREE-EKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVW 587
Query: 286 --EDHVNRNREHNENLNAEMQNLKQKFILEQQER-----EKLQQKELQI---DSLLQQEK 335
E+ + E + +M ++K I EQ+E+ EK++++E +I + + Q+++
Sbjct: 588 RQEEKIREQEEKRQEQEEKMWKQEEK-IREQEEKIQEQEEKIREQEEKIREQEEMTQEQE 646
Query: 336 ELSSSLHQKLCSFQEEMVKEKNLF---EEELKQTLDELDKLQQKEEQAERLVKQLEEEAK 392
E +K+C +E+M +++ EE++++ ++ + ++K + E ++++ EE+
Sbjct: 647 EKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMW 706
Query: 393 SRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSM 433
+ E++ EEK++ +E ++ + + + L+++ + M
Sbjct: 707 EQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKM 747
Score = 70.9 bits (172), Expect = 4e-12
Identities = 78/373 (20%), Positives = 178/373 (47%), Gaps = 41/373 (10%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELE 98
Q+ +R +++K +Q +++ + K++ E KIR ++ Q+ +I + E ++
Sbjct: 409 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQE-KIR 467
Query: 99 KMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKL 158
+ E R +E+ + + +Q E+ + K + ++ +R
Sbjct: 468 EEEKR-----QEQEEMWRQEEKIHEQ-------EEIWRQKEKMHEQEEKIR--------- 506
Query: 159 RNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKS-ETEK 217
K+E K+ K E K++ + + + KI + E EK EK E EK
Sbjct: 507 --KQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEK 564
Query: 218 LLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVK 277
E +++ +++ + + + + EE ++E+ ++ +Q EE + +++ + K
Sbjct: 565 RQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEK----RQEQEEKMWKQEEKIREQEEK 620
Query: 278 CQLLE---KEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKEL--QIDSLLQ 332
Q E +E+E+ + E + +M ++K + EQ+E+ + Q++ + Q + + +
Sbjct: 621 IQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEK-MCEQEEKMQEQEETMWRQEEKIRE 679
Query: 333 QEKELSSSLHQKLCSFQEEMVKEKN--LFEEELKQTLDELDKLQQKEEQAERLVKQL-EE 389
QEK++ ++ QEEM++E+ ++E+E K E +K+Q++EE+ R +++ E+
Sbjct: 680 QEKKIREQ--EEKIREQEEMMQEQEEKMWEQEEKMCEQE-EKMQEQEEKMRRQEEKMWEQ 736
Query: 390 EAKSRAEELKLLE 402
E + R +E K+ E
Sbjct: 737 EVRLRQQEEKMQE 749
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.124 0.316
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,621,556
Number of Sequences: 37866
Number of extensions: 1126329
Number of successful extensions: 32057
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 685
Number of HSP's successfully gapped in prelim test: 1456
Number of HSP's that attempted gapping in prelim test: 8248
Number of HSP's gapped (non-prelim): 8677
length of query: 709
length of database: 18,247,518
effective HSP length: 109
effective length of query: 600
effective length of database: 14,120,124
effective search space: 8472074400
effective search space used: 8472074400
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.