Search of human proteins with 21735562

Search of human proteins with 21735562

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21735562 mitogen-activated protein kinase kinase kinase 7
isoform B [Homo sapiens]
         (606 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso...  1217   0.0  
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof...  1149   0.0  
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso...  1027   0.0  
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso...   959   0.0  
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H...   184   3e-46
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]               166   4e-41
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho...   166   6e-41
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]               165   1e-40
gi|155723000 mixed lineage kinase 4 [Homo sapiens]                    162   6e-40
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho...   160   3e-39
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]          155   1e-37
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]        155   1e-37
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H...   152   1e-36
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho...   151   2e-36
gi|130977759 tec protein tyrosine kinase [Homo sapiens]               136   5e-32
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]                134   2e-31
gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo sapi...   127   2e-29
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [...   127   4e-29
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [...   127   4e-29
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [...   127   4e-29
gi|9910146 chromosome 21 open reading frame 7 [Homo sapiens]          127   4e-29
gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo sap...   125   1e-28
gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo sap...   125   1e-28
gi|10862701 ret proto-oncogene isoform c [Homo sapiens]               125   1e-28
gi|10862703 ret proto-oncogene isoform a [Homo sapiens]               125   1e-28
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    125   1e-28
gi|148596974 TXK tyrosine kinase [Homo sapiens]                       124   3e-28
gi|4758282 ephrin receptor EphA7 [Homo sapiens]                       123   6e-28
gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Hom...   121   2e-27
gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo sa...   121   2e-27

>gi|21735562 mitogen-activated protein kinase kinase kinase 7
           isoform B [Homo sapiens]
          Length = 606

 Score = 1217 bits (3149), Expect = 0.0
 Identities = 606/606 (100%), Positives = 606/606 (100%)

Query: 1   MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV 60
           MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV
Sbjct: 1   MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV 60

Query: 61  AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE 120
           AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE
Sbjct: 61  AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE 120

Query: 121 PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC 180
           PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC
Sbjct: 121 PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC 180

Query: 181 DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM 240
           DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM
Sbjct: 181 DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM 240

Query: 241 WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY 300
           WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY
Sbjct: 241 WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY 300

Query: 301 PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ 360
           PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ
Sbjct: 301 PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ 360

Query: 361 SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGN 420
           SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGN
Sbjct: 361 SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGN 420

Query: 421 ILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP 480
           ILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP
Sbjct: 421 ILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP 480

Query: 481 WTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEI 540
           WTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEI
Sbjct: 481 WTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEI 540

Query: 541 ALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQ 600
           ALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQ
Sbjct: 541 ALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQ 600

Query: 601 KRQGTS 606
           KRQGTS
Sbjct: 601 KRQGTS 606


>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
           A [Homo sapiens]
          Length = 579

 Score = 1149 bits (2973), Expect = 0.0
 Identities = 579/606 (95%), Positives = 579/606 (95%), Gaps = 27/606 (4%)

Query: 1   MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV 60
           MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV
Sbjct: 1   MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV 60

Query: 61  AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE 120
           AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE
Sbjct: 61  AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE 120

Query: 121 PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC 180
           PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC
Sbjct: 121 PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC 180

Query: 181 DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM 240
           DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM
Sbjct: 181 DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM 240

Query: 241 WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY 300
           WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY
Sbjct: 241 WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY 300

Query: 301 PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ 360
           PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ
Sbjct: 301 PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ 360

Query: 361 SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGN 420
           SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATT                 
Sbjct: 361 SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATT----------------- 403

Query: 421 ILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP 480
                     GNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP
Sbjct: 404 ----------GNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP 453

Query: 481 WTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEI 540
           WTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEI
Sbjct: 454 WTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEI 513

Query: 541 ALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQ 600
           ALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQ
Sbjct: 514 ALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQ 573

Query: 601 KRQGTS 606
           KRQGTS
Sbjct: 574 KRQGTS 579


>gi|21735564 mitogen-activated protein kinase kinase kinase 7
           isoform C [Homo sapiens]
          Length = 518

 Score = 1027 bits (2655), Expect = 0.0
 Identities = 509/513 (99%), Positives = 509/513 (99%)

Query: 1   MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV 60
           MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV
Sbjct: 1   MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV 60

Query: 61  AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE 120
           AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE
Sbjct: 61  AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE 120

Query: 121 PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC 180
           PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC
Sbjct: 121 PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC 180

Query: 181 DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM 240
           DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM
Sbjct: 181 DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM 240

Query: 241 WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY 300
           WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY
Sbjct: 241 WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY 300

Query: 301 PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ 360
           PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ
Sbjct: 301 PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ 360

Query: 361 SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGN 420
           SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGN
Sbjct: 361 SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGN 420

Query: 421 ILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP 480
           ILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP
Sbjct: 421 ILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP 480

Query: 481 WTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPC 513
           WTPDDSTDTNGSDNSIPMAYLTLDHQLQ    C
Sbjct: 481 WTPDDSTDTNGSDNSIPMAYLTLDHQLQARTSC 513


>gi|21735566 mitogen-activated protein kinase kinase kinase 7
           isoform D [Homo sapiens]
          Length = 491

 Score =  959 bits (2479), Expect = 0.0
 Identities = 482/513 (93%), Positives = 482/513 (93%), Gaps = 27/513 (5%)

Query: 1   MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV 60
           MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV
Sbjct: 1   MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV 60

Query: 61  AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE 120
           AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE
Sbjct: 61  AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE 120

Query: 121 PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC 180
           PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC
Sbjct: 121 PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC 180

Query: 181 DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM 240
           DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM
Sbjct: 181 DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM 240

Query: 241 WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY 300
           WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY
Sbjct: 241 WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY 300

Query: 301 PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ 360
           PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ
Sbjct: 301 PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ 360

Query: 361 SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGN 420
           SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATT                 
Sbjct: 361 SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATT----------------- 403

Query: 421 ILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP 480
                     GNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP
Sbjct: 404 ----------GNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP 453

Query: 481 WTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPC 513
           WTPDDSTDTNGSDNSIPMAYLTLDHQLQ    C
Sbjct: 454 WTPDDSTDTNGSDNSIPMAYLTLDHQLQARTSC 486


>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
           sapiens]
          Length = 954

 Score =  184 bits (466), Expect = 3e-46
 Identities = 107/278 (38%), Positives = 158/278 (56%), Gaps = 21/278 (7%)

Query: 21  APSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIV---- 76
           AP+ +   +EI + E+++EE++G G FG V +A WR ++VA+K    + E+   +     
Sbjct: 83  APAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQV 142

Query: 77  --ELRQLSRVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMS 132
             E R    + HPNI+ L GACLNP  +CLVMEYA GG+L  VL G    P+      ++
Sbjct: 143 CQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVL----VN 198

Query: 133 WCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAG-------GTVLKICDFGTACDI-QT 184
           W +Q ++G+ YLH+  P  +IHRDLK  N+L++          TVLKI DFG A +  +T
Sbjct: 199 WAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKT 258

Query: 185 HMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVH 244
              +  G+ AWMAPEV   S +S+  DV+S+G++LWE++T   P+ EI   A     A++
Sbjct: 259 TKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMN 318

Query: 245 NGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVK 282
             T  P+    P+P   L+  CW  DP  RP    I+K
Sbjct: 319 KLTL-PIPSTCPEPFARLLEECWDPDPHGRPDFGSILK 355


>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
          Length = 455

 Score =  166 bits (421), Expect = 4e-41
 Identities = 121/396 (30%), Positives = 197/396 (49%), Gaps = 57/396 (14%)

Query: 27  NFEEIDYKEIEVEEVVGRGAFGVVCKAKW--RAKDVAIKQIESESERKAFIVELRQLSRV 84
           +F +I + +++  E  G G+FG V +AKW  + K+VA+K++  + E++A I     LS +
Sbjct: 7   SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-LKIEKEAEI-----LSVL 60

Query: 85  NHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142
           +H NI++ YG  L P    +V EYA  GSLY+ ++           H M+W    ++G+ 
Sbjct: 61  SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRS-EEMDMDHIMTWATDVAKGMH 119

Query: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEV 200
           YLH   P  +IHRDLK  N+++ A G VLKICDFG A     H T+    G+  WMAPEV
Sbjct: 120 YLHMEAPVKVIHRDLKSRNVVIAADG-VLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEV 177

Query: 201 FEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMW-AVHNGTRPPLIKNLPKPI 259
            +    SE CD +S+G++LWE++TR  PF  + G   ++ W  V    R  +  + P+  
Sbjct: 178 IQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEG--LQVAWLVVEKNERLTIPSSCPRSF 235

Query: 260 ESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSF 319
             L+ +CW  D  +RPS ++I+ I+                      E  SN      S 
Sbjct: 236 AELLHQCWEADAKKRPSFKQIISIL----------------------ESMSNDT----SL 269

Query: 320 MDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESL 379
            D  ++   NK++   E + AT + +K+LE  L   + + +    RL +   + +   + 
Sbjct: 270 PDKCNSFLHNKAEWRCE-IEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNT 328

Query: 380 P---PTS---------EGKRMSADMSEIEARIAATT 403
           P   P +         E K   ++ +E+  +I AT+
Sbjct: 329 PLLLPLAARMSEESYFESKTEESNSAEMSCQITATS 364


>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
           sapiens]
          Length = 1118

 Score =  166 bits (420), Expect = 6e-41
 Identities = 110/301 (36%), Positives = 158/301 (52%), Gaps = 26/301 (8%)

Query: 3   TASAASSSSSSSAGE--MIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV 60
           T  +A SS     GE      P Q+L   EID+ E+ +EE++G G FG V +A W   +V
Sbjct: 112 TPRSAFSSRCQPGGEDPSCYPPIQLL---EIDFAELTLEEIIGIGGFGKVYRAFWIGDEV 168

Query: 61  AIKQIESESER--KAFIVELRQLSRV----NHPNIVKLYGACLNP--VCLVMEYAEGGSL 112
           A+K    + +      I  +RQ +++     HPNI+ L G CL    +CLVME+A GG L
Sbjct: 169 AVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPL 228

Query: 113 YNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVA------ 166
             VL G    P       ++W +Q ++G+ YLH      +IHRDLK  N+L++       
Sbjct: 229 NRVLSGKRIPPDIL----VNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGD 284

Query: 167 -GGTVLKICDFGTACDI-QTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVIT 224
               +LKI DFG A +  +T   +  G+ AWMAPEV   S +S+  DV+S+G++LWE++T
Sbjct: 285 LSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLT 344

Query: 225 RRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIM 284
              PF  I G A     A+ N    P+    P+P   LM  CW+ DP  RPS   I+  +
Sbjct: 345 GEVPFRGIDGLAVAYGVAM-NKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQL 403

Query: 285 T 285
           T
Sbjct: 404 T 404


>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
          Length = 800

 Score =  165 bits (418), Expect = 1e-40
 Identities = 114/361 (31%), Positives = 183/361 (50%), Gaps = 45/361 (12%)

Query: 27  NFEEIDYKEIEVEEVVGRGAFGVVCKAKW--RAKDVAIKQIESESERKAFIVELRQLSRV 84
           +F +I + +++  E  G G+FG V +AKW  + K+VA+K++  + E++A I     LS +
Sbjct: 7   SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-LKIEKEAEI-----LSVL 60

Query: 85  NHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142
           +H NI++ YG  L P    +V EYA  GSLY+ ++           H M+W    ++G+ 
Sbjct: 61  SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRS-EEMDMDHIMTWATDVAKGMH 119

Query: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEV 200
           YLH   P  +IHRDLK  N+++ A G VLKICDFG A     H T+    G+  WMAPEV
Sbjct: 120 YLHMEAPVKVIHRDLKSRNVVIAADG-VLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEV 177

Query: 201 FEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMW-AVHNGTRPPLIKNLPKPI 259
            +    SE CD +S+G++LWE++TR  PF  + G   ++ W  V    R  +  + P+  
Sbjct: 178 IQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEG--LQVAWLVVEKNERLTIPSSCPRSF 235

Query: 260 ESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSF 319
             L+ +CW  D  +RPS ++I+ I+                      E  SN      S 
Sbjct: 236 AELLHQCWEADAKKRPSFKQIISIL----------------------ESMSNDT----SL 269

Query: 320 MDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESL 379
            D  ++   NK++   E + AT + +K+LE  L   + + +    RL +   + +   + 
Sbjct: 270 PDKCNSFLHNKAEWRCE-IEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNT 328

Query: 380 P 380
           P
Sbjct: 329 P 329


>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
          Length = 1036

 Score =  162 bits (411), Expect = 6e-40
 Identities = 99/291 (34%), Positives = 156/291 (53%), Gaps = 28/291 (9%)

Query: 22  PSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIV----- 76
           PS+  +   + ++ +E++E++G G FG V +A W+ ++VA+K    + E+ A        
Sbjct: 110 PSRPSSPVHVAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVR 169

Query: 77  -ELRQLSRVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAA----- 128
            E R  + + HPNI++L G CL    +CLV+E+A GG+L   L  A   P   A      
Sbjct: 170 REARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRA 229

Query: 129 -----HAM-SWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAG-------GTVLKICD 175
                H + +W +Q ++G+ YLH      ++HRDLK  N+LL+            LKI D
Sbjct: 230 RRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITD 289

Query: 176 FGTACDI-QTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGG 234
           FG A +  +T   +  G+ AWMAPEV + S +S+  D++S+G++LWE++T   P+  I G
Sbjct: 290 FGLAREWHRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDG 349

Query: 235 PAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMT 285
            A     AV+  T  P+    P+P   LM  CW +DP  RPS   I++ +T
Sbjct: 350 LAVAYGVAVNKLTL-PIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLT 399


>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
           sapiens]
          Length = 847

 Score =  160 bits (405), Expect = 3e-39
 Identities = 147/527 (27%), Positives = 238/527 (45%), Gaps = 59/527 (11%)

Query: 29  EEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIV------ELRQLS 82
           E   ++E+ +EEV+G G FG V +  WR + VA+K    + +    +       E R  +
Sbjct: 110 EVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFA 169

Query: 83  RVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQG 140
            + HPNI+ L   CL    +CLVMEYA GG L   L G    P+      ++W +Q ++G
Sbjct: 170 MLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVL----VNWAVQIARG 225

Query: 141 VAYLHSMQPKALIHRDLKPPNLLLVAG-------GTVLKICDFGTACDI-QTHMTNNKGS 192
           + YLH      +IHRDLK  N+LL+            LKI DFG A +  +T   +  G+
Sbjct: 226 MHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGT 285

Query: 193 AAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLI 252
            AWMAPEV + S +S+  DV+S+G++LWE++T   P+  I   A     AV+  T  P+ 
Sbjct: 286 YAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTL-PIP 344

Query: 253 KNLPKPIESLMTRCWSKDPSQRPS----MEEIVKIMTHLMRYFP-GADEPLQYPCQYSDE 307
              P+P   LM  CW++DP +RP     ++++  +   ++R  P  +   +Q   +   +
Sbjct: 345 STCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQ 404

Query: 308 GQSNSATSTGSFM---DIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAK---QQS 361
           G  +   +    +   +   T  + +  +  EQ+      + + E ++ + +     QQ 
Sbjct: 405 GLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQV 464

Query: 362 ESGRLSLGASRGSSVES-LPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGN 420
           +  R  +   RG+   S L     G+R+S  + + + RI   T  + P    R+      
Sbjct: 465 DRERPHVRRRRGTFKRSKLRARDGGERISMPL-DFKHRI---TVQASPGLDRRRNVFEVG 520

Query: 421 ILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSR--------SSSPSVRMITTSGPTS 472
             D P         PR R+IQ   +   EPGQ   R        SS+   R     GP+S
Sbjct: 521 PGDSPTF-------PRFRAIQ---LEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSS 570

Query: 473 EKPTRSHPW----TPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPN 515
            KP  +         D++T    SD+S P+   +    L    P P+
Sbjct: 571 PKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPS 617


>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
          Length = 835

 Score =  155 bits (391), Expect = 1e-37
 Identities = 96/264 (36%), Positives = 147/264 (55%), Gaps = 18/264 (6%)

Query: 31  IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIE-----SESERKAFIVELRQLSRVN 85
           +   EIE  E++G G+FG V K + R K VAIK+       S+S+   F  E+  L ++N
Sbjct: 458 LQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLN 517

Query: 86  HPNIVKLYGACLNP---VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142
           HP +++  GACLN      +V +Y  GGSL+++LH  E          +   +  ++G+ 
Sbjct: 518 HPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLH--EQKRILDLQSKLIIAVDVAKGME 575

Query: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQT----HMTNNKGSAAWMAP 198
           YLH++  + +IHRDL   N+LL   G  + + DFG +  +Q+    +MT   G+  WMAP
Sbjct: 576 YLHNLT-QPIIHRDLNSHNILLYEDGHAV-VADFGESRFLQSLDEDNMTKQPGNLRWMAP 633

Query: 199 EVF-EGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPK 257
           EVF + + Y+ K DVFS+ + LWE++T   PF  +   A     A H+  RPP+  ++PK
Sbjct: 634 EVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHH-IRPPIGYSIPK 692

Query: 258 PIESLMTRCWSKDPSQRPSMEEIV 281
           PI SL+ R W+  P  RP   E+V
Sbjct: 693 PISSLLIRGWNACPEGRPEFSEVV 716


>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
          Length = 936

 Score =  155 bits (391), Expect = 1e-37
 Identities = 96/264 (36%), Positives = 147/264 (55%), Gaps = 18/264 (6%)

Query: 31  IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIE-----SESERKAFIVELRQLSRVN 85
           +   EIE  E++G G+FG V K + R K VAIK+       S+S+   F  E+  L ++N
Sbjct: 559 LQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLN 618

Query: 86  HPNIVKLYGACLNP---VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142
           HP +++  GACLN      +V +Y  GGSL+++LH  E          +   +  ++G+ 
Sbjct: 619 HPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLH--EQKRILDLQSKLIIAVDVAKGME 676

Query: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQT----HMTNNKGSAAWMAP 198
           YLH++  + +IHRDL   N+LL   G  + + DFG +  +Q+    +MT   G+  WMAP
Sbjct: 677 YLHNLT-QPIIHRDLNSHNILLYEDGHAV-VADFGESRFLQSLDEDNMTKQPGNLRWMAP 734

Query: 199 EVF-EGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPK 257
           EVF + + Y+ K DVFS+ + LWE++T   PF  +   A     A H+  RPP+  ++PK
Sbjct: 735 EVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHH-IRPPIGYSIPK 793

Query: 258 PIESLMTRCWSKDPSQRPSMEEIV 281
           PI SL+ R W+  P  RP   E+V
Sbjct: 794 PISSLLIRGWNACPEGRPEFSEVV 817


>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
           sapiens]
          Length = 859

 Score =  152 bits (383), Expect = 1e-36
 Identities = 86/257 (33%), Positives = 140/257 (54%), Gaps = 19/257 (7%)

Query: 30  EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
           E+ ++EI   + VG GA G V   ++  ++VA+K++    E      +++ L ++ HPNI
Sbjct: 119 EVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKE-----TDIKHLRKLKHPNI 173

Query: 90  VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
           +   G C      C++ME+   G LY VL    P+   T +  + W +  + G+ YLH  
Sbjct: 174 ITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPV---TPSLLVDWSMGIAGGMNYLHLH 230

Query: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEVFEGSN 205
           +   +IHRDLK PN+L+     V+KI DFGT+ ++    T     G+ AWMAPEV     
Sbjct: 231 K---IIHRDLKSPNMLITYDD-VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEP 286

Query: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAV-HNGTRPPLIKNLPKPIESLMT 264
            SEK D++S+G++LWE++T   P+ ++   A  I+W V  N    P+  + P   + L+ 
Sbjct: 287 VSEKVDIWSFGVVLWELLTGEIPYKDVDSSA--IIWGVGSNSLHLPVPSSCPDGFKILLR 344

Query: 265 RCWSKDPSQRPSMEEIV 281
           +CW+  P  RPS  +I+
Sbjct: 345 QCWNSKPRNRPSFRQIL 361


>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
           sapiens]
          Length = 966

 Score =  151 bits (381), Expect = 2e-36
 Identities = 88/255 (34%), Positives = 135/255 (52%), Gaps = 19/255 (7%)

Query: 30  EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
           E+ ++EI   + +G GA G V   K+RA++VAIK++  ++E      +++ L ++ HPNI
Sbjct: 162 EVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNE-----TDIKHLRKLKHPNI 216

Query: 90  VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
           +   G C      C++MEY   G LY VL     +   T    + W    + G+ YLH  
Sbjct: 217 IAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKI---TPRLLVDWSTGIASGMNYLHLH 273

Query: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEVFEGSN 205
           +   +IHRDLK PN+L+     V KI DFGT+ ++    T     G+ AWMAPEV     
Sbjct: 274 K---IIHRDLKSPNVLVTHTDAV-KISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEP 329

Query: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAV-HNGTRPPLIKNLPKPIESLMT 264
            SEK D++S+G++LWE++T   P+ ++   A  I+W V  N    P+    P   + LM 
Sbjct: 330 VSEKVDIWSFGVVLWELLTGEIPYKDVDSSA--IIWGVGSNSLHLPVPSTCPDGFKILMK 387

Query: 265 RCWSKDPSQRPSMEE 279
           + W   P  RPS  +
Sbjct: 388 QTWQSKPRNRPSFRQ 402


>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
          Length = 631

 Score =  136 bits (343), Expect = 5e-32
 Identities = 92/268 (34%), Positives = 139/268 (51%), Gaps = 17/268 (6%)

Query: 30  EIDYKEIEVEEVVGRGAFGVVCKAKWRAK-DVAIKQI-ESESERKAFIVELRQLSRVNHP 87
           EI+  E+     +G G FGVV   KWRA+  VAIK I E     + FI E + + ++ HP
Sbjct: 364 EINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHP 423

Query: 88  NIVKLYGACLN--PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH 145
            +V+LYG C    P+ +V E+ E G L N L   +   +++    +S C    +G+ YL 
Sbjct: 424 KLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQG--HFSRDVLLSMCQDVCEGMEYL- 480

Query: 146 SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC----DIQTHMTNNKGSAAWMAPEVF 201
             +  + IHRDL   N L+   G V+K+ DFG A     D  T  +  K    W  PEVF
Sbjct: 481 --ERNSFIHRDLAARNCLVSEAG-VVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVF 537

Query: 202 EGSNYSEKCDVFSWGIILWEVITR-RKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIE 260
             S +S K DV+S+G+++WEV T  R PF++     + ++  V  G R    K     + 
Sbjct: 538 NYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTN--YEVVTMVTRGHRLYQPKLASNYVY 595

Query: 261 SLMTRCWSKDPSQRPSMEEIVKIMTHLM 288
            +M RCW + P  RPS E++++ +  L+
Sbjct: 596 EVMLRCWQEKPEGRPSFEDLLRTIDELV 623


>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
          Length = 620

 Score =  134 bits (337), Expect = 2e-31
 Identities = 88/266 (33%), Positives = 132/266 (49%), Gaps = 17/266 (6%)

Query: 31  IDYKEIEVEEVVGRGAFGVVCKAKWRAKD-VAIKQI-ESESERKAFIVELRQLSRVNHPN 88
           ID  E+   + +G G FG+V    W  KD VAIK I E     + FI E   + +++HP 
Sbjct: 358 IDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPK 417

Query: 89  IVKLYGACLN--PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHS 146
           +V+LYG CL   P+CLV E+ E G L + L     L  + A   +  CL   +G+AYL  
Sbjct: 418 LVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGL--FAAETLLGMCLDVCEGMAYL-- 473

Query: 147 MQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC----DIQTHMTNNKGSAAWMAPEVFE 202
            +   +IHRDL   N L V    V+K+ DFG       D  T  T  K    W +PEVF 
Sbjct: 474 -EEACVIHRDLAARNCL-VGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFS 531

Query: 203 GSNYSEKCDVFSWGIILWEVITRRK-PFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIES 261
            S YS K DV+S+G+++WEV +  K P++        ++  +  G R    +     +  
Sbjct: 532 FSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNS--EVVEDISTGFRLYKPRLASTHVYQ 589

Query: 262 LMTRCWSKDPSQRPSMEEIVKIMTHL 287
           +M  CW + P  RP+   +++ +  +
Sbjct: 590 IMNHCWKERPEDRPAFSRLLRQLAEI 615


>gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo
           sapiens]
          Length = 983

 Score =  127 bits (320), Expect = 2e-29
 Identities = 93/291 (31%), Positives = 146/291 (50%), Gaps = 31/291 (10%)

Query: 20  EAPSQVLN--FEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKD-----VAIKQIE---SES 69
           E P+Q ++   +E+D   I +++VVG G FG VC  + +        VAIK ++   +E 
Sbjct: 603 EDPTQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEK 662

Query: 70  ERKAFIVELRQLSRVNHPNIVKLYGACLN--PVCLVMEYAEGGSLYNVL--HGAEPLPYY 125
           +R+ F+ E   + + +HPNI++L G      PV +V EY E GSL + L  H A+    +
Sbjct: 663 QRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQ----F 718

Query: 126 TAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC----D 181
           T    +      + G+ YL  M     +HRDL   N+L +    V K+ DFG +     D
Sbjct: 719 TVIQLVGMLRGIASGMKYLSDM---GYVHRDLAARNIL-INSNLVCKVSDFGLSRVLEDD 774

Query: 182 IQTHMTNNKGSAA--WMAPEVFEGSNYSEKCDVFSWGIILWEVITR-RKPFDEIGGPAFR 238
            +   T   G     W +PE      ++   DV+S+GI+LWEV++   +P+ E+      
Sbjct: 775 PEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQD-- 832

Query: 239 IMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMR 289
           ++ AV  G R P   + P  +  LM  CW KD + RP  E+IV I+  L+R
Sbjct: 833 VIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIR 883


>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
           [Homo sapiens]
          Length = 466

 Score =  127 bits (318), Expect = 4e-29
 Identities = 80/280 (28%), Positives = 144/280 (51%), Gaps = 14/280 (5%)

Query: 12  SSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESER 71
           + SA E +     +LN + +      +   +G G FG V + ++  + VA+K I+ +   
Sbjct: 175 TKSAEEELARAGWLLNLQHLT-----LGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTA 229

Query: 72  KAFIVELRQLSRVNHPNIVKLYGACLNP-VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHA 130
           +AF+ E   ++++ H N+V+L G  L+  + +VME+   G+L N L           A  
Sbjct: 230 QAFLDETAVMTKMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLR-TRGRALVNTAQL 288

Query: 131 MSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK 190
           + + L  ++G+ YL S   K L+HRDL   N+L V+   V K+ DFG A   +  + +++
Sbjct: 289 LQFSLHVAEGMEYLES---KKLVHRDLAARNIL-VSEDLVAKVSDFGLAKAERKGLDSSR 344

Query: 191 GSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVIT-RRKPFDEIGGPAFRIMWAVHNGTRP 249
               W APE  +   ++ K DV+S+G++LWEV +  R P+ ++      +  AV  G R 
Sbjct: 345 LPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMS--LKEVSEAVEKGYRM 402

Query: 250 PLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMR 289
              +  P P+  LM+ CW  +P++RP   ++ + +   +R
Sbjct: 403 EPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELR 442


>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
           [Homo sapiens]
          Length = 508

 Score =  127 bits (318), Expect = 4e-29
 Identities = 80/280 (28%), Positives = 144/280 (51%), Gaps = 14/280 (5%)

Query: 12  SSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESER 71
           + SA E +     +LN + +      +   +G G FG V + ++  + VA+K I+ +   
Sbjct: 217 TKSAEEELARAGWLLNLQHLT-----LGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTA 271

Query: 72  KAFIVELRQLSRVNHPNIVKLYGACLNP-VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHA 130
           +AF+ E   ++++ H N+V+L G  L+  + +VME+   G+L N L           A  
Sbjct: 272 QAFLDETAVMTKMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLR-TRGRALVNTAQL 330

Query: 131 MSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK 190
           + + L  ++G+ YL S   K L+HRDL   N+L V+   V K+ DFG A   +  + +++
Sbjct: 331 LQFSLHVAEGMEYLES---KKLVHRDLAARNIL-VSEDLVAKVSDFGLAKAERKGLDSSR 386

Query: 191 GSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVIT-RRKPFDEIGGPAFRIMWAVHNGTRP 249
               W APE  +   ++ K DV+S+G++LWEV +  R P+ ++      +  AV  G R 
Sbjct: 387 LPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMS--LKEVSEAVEKGYRM 444

Query: 250 PLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMR 289
              +  P P+  LM+ CW  +P++RP   ++ + +   +R
Sbjct: 445 EPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELR 484


>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
           [Homo sapiens]
          Length = 507

 Score =  127 bits (318), Expect = 4e-29
 Identities = 80/280 (28%), Positives = 144/280 (51%), Gaps = 14/280 (5%)

Query: 12  SSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESER 71
           + SA E +     +LN + +      +   +G G FG V + ++  + VA+K I+ +   
Sbjct: 216 TKSAEEELARAGWLLNLQHLT-----LGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTA 270

Query: 72  KAFIVELRQLSRVNHPNIVKLYGACLNP-VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHA 130
           +AF+ E   ++++ H N+V+L G  L+  + +VME+   G+L N L           A  
Sbjct: 271 QAFLDETAVMTKMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLR-TRGRALVNTAQL 329

Query: 131 MSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK 190
           + + L  ++G+ YL S   K L+HRDL   N+L V+   V K+ DFG A   +  + +++
Sbjct: 330 LQFSLHVAEGMEYLES---KKLVHRDLAARNIL-VSEDLVAKVSDFGLAKAERKGLDSSR 385

Query: 191 GSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVIT-RRKPFDEIGGPAFRIMWAVHNGTRP 249
               W APE  +   ++ K DV+S+G++LWEV +  R P+ ++      +  AV  G R 
Sbjct: 386 LPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMS--LKEVSEAVEKGYRM 443

Query: 250 PLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMR 289
              +  P P+  LM+ CW  +P++RP   ++ + +   +R
Sbjct: 444 EPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELR 483


>gi|9910146 chromosome 21 open reading frame 7 [Homo sapiens]
          Length = 242

 Score =  127 bits (318), Expect = 4e-29
 Identities = 62/124 (50%), Positives = 89/124 (71%)

Query: 483 PDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIAL 542
           P    D    ++SIP+ +  LD QLQPL PC +S+ESM VF+QHC++A+EY +V+ EI L
Sbjct: 119 PSSPLDDTPPEDSIPLVFPELDQQLQPLPPCHDSEESMEVFKQHCQIAEEYHEVKKEITL 178

Query: 543 LLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKR 602
           L QRK+EL+A+LDQ EK++ + + LV+E + L +EN++L     QC +QLE +R Q QKR
Sbjct: 179 LEQRKKELIAKLDQAEKEKVDAAELVREFEALTEENRTLRLAQSQCVEQLEKLRIQYQKR 238

Query: 603 QGTS 606
           QG+S
Sbjct: 239 QGSS 242


>gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo
           sapiens]
          Length = 1015

 Score =  125 bits (313), Expect = 1e-28
 Identities = 95/322 (29%), Positives = 153/322 (47%), Gaps = 27/322 (8%)

Query: 20  EAPSQVLN--FEEIDYKEIEVEEVVGRGAFGVVCKAKW-----RAKDVAIKQIE---SES 69
           E P+Q ++   +EI+   I +E V+G G FG VC  +      R   VAIK ++   +E 
Sbjct: 635 EDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEK 694

Query: 70  ERKAFIVELRQLSRVNHPNIVKLYGACLN--PVCLVMEYAEGGSLYNVLHGAEPLPYYTA 127
           +R+ F+ E   + + +HPNI+ L G      PV +V EY E GSL   L   +    +T 
Sbjct: 695 QRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDG--QFTV 752

Query: 128 AHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC----DIQ 183
              +      S G+ YL  M     +HRDL   N+L +    V K+ DFG +     D +
Sbjct: 753 IQLVGMLRGISAGMKYLSDM---GYVHRDLAARNIL-INSNLVCKVSDFGLSRVLEDDPE 808

Query: 184 THMTNNKGSAA--WMAPEVFEGSNYSEKCDVFSWGIILWEVITR-RKPFDEIGGPAFRIM 240
              T   G     W APE      ++   DV+S+GI++WEV++   +P+ E+      ++
Sbjct: 809 AAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQD--VI 866

Query: 241 WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY 300
            AV  G R P   + P  +  LM  CW K+ + RP  +EIV ++  L+R        +  
Sbjct: 867 KAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRNPSSLKTLVNA 926

Query: 301 PCQYSDEGQSNSATSTGSFMDI 322
            C+ S+    +S   +G++  +
Sbjct: 927 SCRVSNLLAEHSPLGSGAYRSV 948


>gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo
           sapiens]
          Length = 1037

 Score =  125 bits (313), Expect = 1e-28
 Identities = 95/322 (29%), Positives = 153/322 (47%), Gaps = 27/322 (8%)

Query: 20  EAPSQVLN--FEEIDYKEIEVEEVVGRGAFGVVCKAKW-----RAKDVAIKQIE---SES 69
           E P+Q ++   +EI+   I +E V+G G FG VC  +      R   VAIK ++   +E 
Sbjct: 657 EDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEK 716

Query: 70  ERKAFIVELRQLSRVNHPNIVKLYGACLN--PVCLVMEYAEGGSLYNVLHGAEPLPYYTA 127
           +R+ F+ E   + + +HPNI+ L G      PV +V EY E GSL   L   +    +T 
Sbjct: 717 QRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDG--QFTV 774

Query: 128 AHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC----DIQ 183
              +      S G+ YL  M     +HRDL   N+L +    V K+ DFG +     D +
Sbjct: 775 IQLVGMLRGISAGMKYLSDM---GYVHRDLAARNIL-INSNLVCKVSDFGLSRVLEDDPE 830

Query: 184 THMTNNKGSAA--WMAPEVFEGSNYSEKCDVFSWGIILWEVITR-RKPFDEIGGPAFRIM 240
              T   G     W APE      ++   DV+S+GI++WEV++   +P+ E+      ++
Sbjct: 831 AAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQD--VI 888

Query: 241 WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY 300
            AV  G R P   + P  +  LM  CW K+ + RP  +EIV ++  L+R        +  
Sbjct: 889 KAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRNPSSLKTLVNA 948

Query: 301 PCQYSDEGQSNSATSTGSFMDI 322
            C+ S+    +S   +G++  +
Sbjct: 949 SCRVSNLLAEHSPLGSGAYRSV 970


>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
          Length = 1072

 Score =  125 bits (313), Expect = 1e-28
 Identities = 97/298 (32%), Positives = 150/298 (50%), Gaps = 45/298 (15%)

Query: 30   EIDYKEIEVEEVVGRGAFGVVCKA-----KWRA--KDVAIKQIE---SESERKAFIVELR 79
            E   K + + + +G G FG V KA     K RA    VA+K ++   S SE +  + E  
Sbjct: 718  EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFN 777

Query: 80   QLSRVNHPNIVKLYGACL--NPVCLVMEYAEGGSLYNVLHGAEPL-PYY----------- 125
             L +VNHP+++KLYGAC    P+ L++EYA+ GSL   L  +  + P Y           
Sbjct: 778  VLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSS 837

Query: 126  ---------TAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDF 176
                     T    +S+  Q SQG+ YL  M+   L+HRDL   N +LVA G  +KI DF
Sbjct: 838  LDHPDERALTMGDLISFAWQISQGMQYLAEMK---LVHRDLAARN-ILVAEGRKMKISDF 893

Query: 177  GTACDI---QTHMTNNKG--SAAWMAPEVFEGSNYSEKCDVFSWGIILWEVIT-RRKPFD 230
            G + D+    +++  ++G     WMA E      Y+ + DV+S+G++LWE++T    P+ 
Sbjct: 894  GLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYP 953

Query: 231  EIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLM 288
              G P  R+   +  G R     N  + +  LM +CW ++P +RP   +I K +  +M
Sbjct: 954  --GIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 1009


>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
          Length = 1114

 Score =  125 bits (313), Expect = 1e-28
 Identities = 97/298 (32%), Positives = 150/298 (50%), Gaps = 45/298 (15%)

Query: 30   EIDYKEIEVEEVVGRGAFGVVCKA-----KWRA--KDVAIKQIE---SESERKAFIVELR 79
            E   K + + + +G G FG V KA     K RA    VA+K ++   S SE +  + E  
Sbjct: 718  EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFN 777

Query: 80   QLSRVNHPNIVKLYGACL--NPVCLVMEYAEGGSLYNVLHGAEPL-PYY----------- 125
             L +VNHP+++KLYGAC    P+ L++EYA+ GSL   L  +  + P Y           
Sbjct: 778  VLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSS 837

Query: 126  ---------TAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDF 176
                     T    +S+  Q SQG+ YL  M+   L+HRDL   N +LVA G  +KI DF
Sbjct: 838  LDHPDERALTMGDLISFAWQISQGMQYLAEMK---LVHRDLAARN-ILVAEGRKMKISDF 893

Query: 177  GTACDI---QTHMTNNKG--SAAWMAPEVFEGSNYSEKCDVFSWGIILWEVIT-RRKPFD 230
            G + D+    +++  ++G     WMA E      Y+ + DV+S+G++LWE++T    P+ 
Sbjct: 894  GLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYP 953

Query: 231  EIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLM 288
              G P  R+   +  G R     N  + +  LM +CW ++P +RP   +I K +  +M
Sbjct: 954  --GIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 1009


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  125 bits (313), Expect = 1e-28
 Identities = 123/411 (29%), Positives = 180/411 (43%), Gaps = 66/411 (16%)

Query: 40  EVVGRGAFGVVCKAK------WRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLY 93
           E VG G FG V K +      W A   +      + ER   + E +++       I+ +Y
Sbjct: 26  EKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVY 85

Query: 94  GACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALI 153
           G C  PV LVMEY E GSL  +L  +EPLP+      +    + + G+ +LH M P  L+
Sbjct: 86  GICREPVGLVMEYMETGSLEKLL-ASEPLPWDLRFRIIH---ETAVGMNFLHCMAP-PLL 140

Query: 154 HRDLKPPNLLLVAGGTVLKICDFGTA-CDIQTH-----MTNNKGSAAWMAPEVFEGSN-- 205
           H DLKP N+LL A   V KI DFG A C+  +H     M    G+ A++ PE     +  
Sbjct: 141 HLDLKPANILLDAHYHV-KISDFGLAKCNGLSHSHDLSMDGLFGTIAYLPPERIREKSRL 199

Query: 206 YSEKCDVFSWGIILWEVITRRKPF-DEIGGPAFRIMWAVHNGTR---PPLIKNLPKP--- 258
           +  K DV+S+ I++W V+T++KPF DE       IM  V  G R   PP+ +  P+    
Sbjct: 200 FDTKHDVYSFAIVIWGVLTQKKPFADEKN--ILHIMVKVVKGHRPELPPVCRARPRACSH 257

Query: 259 IESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGS 318
           +  LM RCW  DP  RP+ +EI      L              C+  D+        T  
Sbjct: 258 LIRLMQRCWQGDPRVRPTFQEITSETEDL--------------CEKPDD----EVKETAH 299

Query: 319 FMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGA-------- 370
            +D+ S       +   E VPA    +KR  +    N         +L  G         
Sbjct: 300 DLDVKS-----PPEPRSEVVPA---RLKRASAPTFDNDYSLSELLSQLDSGVSQAVEGPE 351

Query: 371 --SRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFG 419
             SR SS   LP +  GKR+S  +S +++  ++  + S        T+  G
Sbjct: 352 ELSRSSSESKLPSSGSGKRLSG-VSSVDSAFSSRGSLSLSFEREPSTSDLG 401


>gi|148596974 TXK tyrosine kinase [Homo sapiens]
          Length = 527

 Score =  124 bits (310), Expect = 3e-28
 Identities = 88/267 (32%), Positives = 135/267 (50%), Gaps = 17/267 (6%)

Query: 30  EIDYKEIEVEEVVGRGAFGVVCKAKWRAK-DVAIKQI-ESESERKAFIVELRQLSRVNHP 87
           EID  E+   + +G G FGVV   +WR+   VAIK I E     + FI E + + +++H 
Sbjct: 265 EIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHS 324

Query: 88  NIVKLYGACLN--PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH 145
            +V+LYG C+   P+ +V E+ E G L N L   E          +S C    +G+ YL 
Sbjct: 325 KLVQLYGVCIQRKPLYIVTEFMENGCLLNYLR--ENKGKLRKEMLLSVCQDICEGMEYL- 381

Query: 146 SMQPKALIHRDLKPPNLLLVAGGTVLKICDFG-TACDIQTHMTNNKGSA---AWMAPEVF 201
             +    IHRDL   N L V+   ++KI DFG T   +     ++ G+     W  PEVF
Sbjct: 382 --ERNGYIHRDLAARNCL-VSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVF 438

Query: 202 EGSNYSEKCDVFSWGIILWEVITRRK-PFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIE 260
             + YS K DV+S+G+++WEV T  K PF+       +++ A+  G R       P  I 
Sbjct: 439 LFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSN--LQVVEAISEGFRLYRPHLAPMSIY 496

Query: 261 SLMTRCWSKDPSQRPSMEEIVKIMTHL 287
            +M  CW + P  RP+  E+++ +T +
Sbjct: 497 EVMYSCWHEKPEGRPTFAELLRAVTEI 523


>gi|4758282 ephrin receptor EphA7 [Homo sapiens]
          Length = 998

 Score =  123 bits (308), Expect = 6e-28
 Identities = 86/292 (29%), Positives = 146/292 (50%), Gaps = 27/292 (9%)

Query: 17  EMIEAPSQVLN--FEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKD-----VAIKQIE--- 66
           E  E P++ ++   +E+D   I++E V+G G FG VC  + +        VAIK ++   
Sbjct: 612 ETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGY 671

Query: 67  SESERKAFIVELRQLSRVNHPNIVKLYGACLN--PVCLVMEYAEGGSLYNVLHGAEPLPY 124
           +E +R+ F+ E   + + +HPN+V L G      PV +V+E+ E G+L   L   +    
Sbjct: 672 TEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDG--Q 729

Query: 125 YTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQT 184
           +T    +      + G+ YL  M     +HRDL   N+L V    V K+ DFG +  I+ 
Sbjct: 730 FTVIQLVGMLRGIAAGMRYLADM---GYVHRDLAARNIL-VNSNLVCKVSDFGLSRVIED 785

Query: 185 H------MTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITR-RKPFDEIGGPAF 237
                   T  K    W APE  +   ++   DV+S+GI++WEV++   +P+ ++     
Sbjct: 786 DPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQD- 844

Query: 238 RIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMR 289
            ++ A+  G R P   + P  +  LM  CW K+ ++RP  E+IV I+  ++R
Sbjct: 845 -VIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQIVGILDKMIR 895


>gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Homo
           sapiens]
          Length = 648

 Score =  121 bits (304), Expect = 2e-27
 Identities = 98/311 (31%), Positives = 157/311 (50%), Gaps = 33/311 (10%)

Query: 30  EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIE----SESERKAFIVELRQLSRVN 85
           EI+  E+ +   +G G+FG V K KW   DVA+K ++    +  + +AF  E+  L +  
Sbjct: 343 EIEASEVMLSTRIGSGSFGTVYKGKWHG-DVAVKILKVVDPTPEQFQAFRNEVAVLRKTR 401

Query: 86  HPNIVKLYGACLNP-VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYL 144
           H NI+   G      + +V ++ EG SLY  LH  E    +     +    Q +QG+ YL
Sbjct: 402 HVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETK--FQMFQLIDIARQTAQGMDYL 459

Query: 145 HSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK------GSAAWMAP 198
           H+   K +IHRD+K  N+ L  G TV KI DFG A  +++  + ++      GS  WMAP
Sbjct: 460 HA---KNIIHRDMKSNNIFLHEGLTV-KIGDFGLAT-VKSRWSGSQQVEQPTGSVLWMAP 514

Query: 199 EVF---EGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPP----L 251
           EV    + + +S + DV+S+GI+L+E++T   P+  I     +I++ V  G   P    L
Sbjct: 515 EVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINN-RDQIIFMVGRGYASPDLSKL 573

Query: 252 IKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFP----GADEPLQYPCQYSDE 307
            KN PK ++ L+  C  K   +RP   +I+  +  L    P     A EP  +   ++++
Sbjct: 574 YKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTED 633

Query: 308 GQSNSATSTGS 318
              N+ T T S
Sbjct: 634 --INACTLTTS 642


>gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo
            sapiens]
          Length = 1328

 Score =  121 bits (304), Expect = 2e-27
 Identities = 81/263 (30%), Positives = 131/263 (49%), Gaps = 27/263 (10%)

Query: 40   EVVGRGAFGVV-CKAKWRAKDVAIKQIE--------SESERKAFIVELRQLSRVNHPNIV 90
            E++G+GA+G V C    + + +A+KQ+         +E E +    E+  L  + H NIV
Sbjct: 1065 EILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIV 1124

Query: 91   KLYGACL--NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQ 148
               G CL  N V + ME+  GGS+ ++++   PLP         +  Q  QGVAYLH   
Sbjct: 1125 AYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFC---KYTKQILQGVAYLHE-- 1179

Query: 149  PKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQ------TH---MTNNKGSAAWMAPE 199
               ++HRD+K  N++L+  G ++K+ DFG A  +       TH   + +  G+  WMAPE
Sbjct: 1180 -NCVVHRDIKGNNVMLMPTG-IIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPE 1237

Query: 200  VFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPI 259
            V   S Y  K D++S G  ++E+ T + P   +   A       H G  PPL  +  +  
Sbjct: 1238 VINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENA 1297

Query: 260  ESLMTRCWSKDPSQRPSMEEIVK 282
               +  C ++D  +RPS  +++K
Sbjct: 1298 ADFVRMCLTRDQHERPSALQLLK 1320


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.127    0.370 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,318,241
Number of Sequences: 37866
Number of extensions: 1164562
Number of successful extensions: 7286
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 470
Number of HSP's successfully gapped in prelim test: 500
Number of HSP's that attempted gapping in prelim test: 4708
Number of HSP's gapped (non-prelim): 1539
length of query: 606
length of database: 18,247,518
effective HSP length: 108
effective length of query: 498
effective length of database: 14,157,990
effective search space: 7050679020
effective search space used: 7050679020
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.