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Search of human proteins with 21729895
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21729895 mitogen-activated protein kinase kinase 5 isoform A
[Homo sapiens]
(448 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21729895 mitogen-activated protein kinase kinase 5 isoform A ... 904 0.0
gi|4506101 mitogen-activated protein kinase kinase 5 isoform B [... 875 0.0
gi|5579478 mitogen-activated protein kinase kinase 1 [Homo sapiens] 263 3e-70
gi|13489054 mitogen-activated protein kinase kinase 2 [Homo sapi... 254 1e-67
gi|14589900 mitogen-activated protein kinase kinase 6 [Homo sapi... 220 2e-57
gi|21618347 mitogen-activated protein kinase kinase 3 isoform A ... 209 3e-54
gi|21618349 mitogen-activated protein kinase kinase 3 isoform B ... 209 3e-54
gi|4506889 mitogen-activated protein kinase kinase 4 [Homo sapiens] 205 6e-53
gi|21735544 mitogen-activated protein kinase kinase 7 [Homo sapi... 169 4e-42
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 167 2e-41
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 167 2e-41
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 166 5e-41
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 166 5e-41
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 165 7e-41
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 164 1e-40
gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens] 150 2e-36
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 142 5e-34
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 141 1e-33
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 141 1e-33
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 141 1e-33
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 141 1e-33
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 141 1e-33
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 141 1e-33
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 141 1e-33
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 141 1e-33
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 141 1e-33
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 135 6e-32
gi|4826878 oxidative-stress responsive 1 [Homo sapiens] 134 2e-31
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 134 2e-31
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 134 2e-31
>gi|21729895 mitogen-activated protein kinase kinase 5 isoform A
[Homo sapiens]
Length = 448
Score = 904 bits (2336), Expect = 0.0
Identities = 448/448 (100%), Positives = 448/448 (100%)
Query: 1 MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAF 60
MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAF
Sbjct: 1 MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAF 60
Query: 61 EYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL 120
EYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL
Sbjct: 61 EYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL 120
Query: 121 KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV 180
KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV
Sbjct: 121 KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV 180
Query: 181 YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC 240
YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC
Sbjct: 181 YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC 240
Query: 241 TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC 300
TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC
Sbjct: 241 TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC 300
Query: 301 DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQ 360
DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQ
Sbjct: 301 DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQ 360
Query: 361 KNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV 420
KNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV
Sbjct: 361 KNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV 420
Query: 421 QFNDGNAAVVSMWVCRALEERRSQQGPP 448
QFNDGNAAVVSMWVCRALEERRSQQGPP
Sbjct: 421 QFNDGNAAVVSMWVCRALEERRSQQGPP 448
>gi|4506101 mitogen-activated protein kinase kinase 5 isoform B
[Homo sapiens]
Length = 438
Score = 875 bits (2260), Expect = 0.0
Identities = 438/448 (97%), Positives = 438/448 (97%), Gaps = 10/448 (2%)
Query: 1 MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAF 60
MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAF
Sbjct: 1 MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAF 60
Query: 61 EYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL 120
EYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL
Sbjct: 61 EYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL 120
Query: 121 KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV 180
KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV
Sbjct: 121 KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV 180
Query: 181 YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC 240
YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC
Sbjct: 181 YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC 240
Query: 241 TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC 300
TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC
Sbjct: 241 TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC 300
Query: 301 DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQ 360
DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFME IQ
Sbjct: 301 DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFME----------IQ 350
Query: 361 KNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV 420
KNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV
Sbjct: 351 KNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV 410
Query: 421 QFNDGNAAVVSMWVCRALEERRSQQGPP 448
QFNDGNAAVVSMWVCRALEERRSQQGPP
Sbjct: 411 QFNDGNAAVVSMWVCRALEERRSQQGPP 438
>gi|5579478 mitogen-activated protein kinase kinase 1 [Homo sapiens]
Length = 393
Score = 263 bits (671), Expect = 3e-70
Identities = 142/339 (41%), Positives = 204/339 (60%), Gaps = 41/339 (12%)
Query: 140 LPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILL 199
L K+ A L + G++ + D LG GNGG V+K H PSG ++A K+I L
Sbjct: 42 LDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL 101
Query: 200 DITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRK----M 255
+I ++ QI+ EL++L++C+S YI+GFYGAF+ + ISIC E MDGGSLD K +
Sbjct: 102 EIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRI 161
Query: 256 PEHVLGRIAVAVVKGLTYLWSL-KILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK 314
PE +LG++++AV+KGLTYL KI+HRDVKPSN+LVN+RG++KLCDFGVS QL++S+A
Sbjct: 162 PEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN 221
Query: 315 TYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLM------- 367
++VGT +YM+PER+ G Y + SD+WS+G+S +E+A+GR+P P + LM
Sbjct: 222 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEG 281
Query: 368 --------------PL--------------QLLQCIVDEDSPVLPVGEFSEPFVHFITQC 399
PL +LL IV+E P LP G FS F F+ +C
Sbjct: 282 DAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKC 341
Query: 400 MRKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVCRAL 438
+ K P ER ++LM H FI + +D + W+C +
Sbjct: 342 LIKNPAERADLKQLMVHAFIKR-SDAEEVDFAGWLCSTI 379
>gi|13489054 mitogen-activated protein kinase kinase 2 [Homo
sapiens]
Length = 400
Score = 254 bits (649), Expect = 1e-67
Identities = 142/353 (40%), Positives = 208/353 (58%), Gaps = 47/353 (13%)
Query: 140 LPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILL 199
L K+ A L + G++ + D LG GNGG V K H PSG I+A K+I L
Sbjct: 46 LDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHL 105
Query: 200 DITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVY----RKM 255
+I ++ QI+ EL++L++C+S YI+GFYGAF+ + ISIC E MDGGSLD +++
Sbjct: 106 EIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRI 165
Query: 256 PEHVLGRIAVAVVKGLTYLWSL-KILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK 314
PE +LG++++AV++GL YL +I+HRDVKPSN+LVN+RG++KLCDFGVS QL++S+A
Sbjct: 166 PEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN 225
Query: 315 TYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQ--------------IQ 360
++VGT +YMAPER+ G Y + SD+WS+G+S +ELA+GR+P P +
Sbjct: 226 SFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVD 285
Query: 361 KNQG---SLMP----------------------LQLLQCIVDEDSPVLPVGEFSEPFVHF 395
+G S+ P +LL IV+E P LP G F+ F F
Sbjct: 286 GEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEF 345
Query: 396 ITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVCRALEERRSQQGPP 448
+ +C+ K P ER + L H FI + ++ + W+C+ L R +Q G P
Sbjct: 346 VNKCLIKNPAERADLKMLTNHTFIKR-SEVEEVDFAGWLCKTL--RLNQPGTP 395
>gi|14589900 mitogen-activated protein kinase kinase 6 [Homo
sapiens]
Length = 334
Score = 220 bits (560), Expect = 2e-57
Identities = 139/334 (41%), Positives = 192/334 (57%), Gaps = 28/334 (8%)
Query: 113 GERNIHGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTL 172
G++ GLK+ A P S + P + K+ + N ++ D+ L
Sbjct: 6 GKKRNPGLKIPKEA----FEQPQTSSTPPRDLDSKACISIGN--QNFEVKADDLEPIMEL 59
Query: 173 GHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSSYIIGFYGAF 231
G G G V K HVPSG+I+AVK I + + QK+++ +L+I + D + + FYGA
Sbjct: 60 GRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGAL 119
Query: 232 FVENRISICTEFMDGGSLDVYRK--------MPEHVLGRIAVAVVKGLTYLWS-LKILHR 282
F E + IC E MD SLD + K +PE +LG+IAV++VK L +L S L ++HR
Sbjct: 120 FREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHR 178
Query: 283 DVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPERISGE----QYGIHS 337
DVKPSN+L+N GQVK+CDFG+S LV+S+AKT G YMAPERI+ E Y + S
Sbjct: 179 DVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKS 238
Query: 338 DVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFIT 397
D+WSLGI+ +ELA+ RFPY + G+ P Q L+ +V+E SP LP +FS FV F +
Sbjct: 239 DIWSLGITMIELAILRFPY----DSWGT--PFQQLKQVVEEPSPQLPADKFSAEFVDFTS 292
Query: 398 QCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVS 431
QC++K KERP ELM HPF V S
Sbjct: 293 QCLKKNSKERPTYPELMQHPFFTLHESKGTDVAS 326
>gi|21618347 mitogen-activated protein kinase kinase 3 isoform A
[Homo sapiens]
Length = 318
Score = 209 bits (533), Expect = 3e-54
Identities = 124/275 (45%), Positives = 166/275 (60%), Gaps = 20/275 (7%)
Query: 158 NGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEI-L 216
N ++ D+ LG G G V K H SG I+AVK I + + QK+++ +L+I +
Sbjct: 27 NFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINM 86
Query: 217 YKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKM-------PEHVLGRIAVAVVK 269
D Y + FYGA F E + IC E MD YRK+ PE +LG IAV++V+
Sbjct: 87 RTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVR 146
Query: 270 GLTYLWS-LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPER 327
L +L S L ++HRDVKPSN+L+N G VK+CDFG+S LV+S+AKT G YMAPER
Sbjct: 147 ALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPER 206
Query: 328 ISGE----QYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVL 383
I+ E Y + SDVWSLGI+ +E+A+ RFPY ++ G+ P Q L+ +V+E SP L
Sbjct: 207 INPELNQKGYNVKSDVWSLGITMIEMAILRFPY----ESWGT--PFQQLKQVVEEPSPQL 260
Query: 384 PVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPF 418
P FS FV F QC+RK P ER + ELM HPF
Sbjct: 261 PADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPF 295
>gi|21618349 mitogen-activated protein kinase kinase 3 isoform B
[Homo sapiens]
Length = 347
Score = 209 bits (533), Expect = 3e-54
Identities = 124/275 (45%), Positives = 166/275 (60%), Gaps = 20/275 (7%)
Query: 158 NGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEI-L 216
N ++ D+ LG G G V K H SG I+AVK I + + QK+++ +L+I +
Sbjct: 56 NFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINM 115
Query: 217 YKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKM-------PEHVLGRIAVAVVK 269
D Y + FYGA F E + IC E MD YRK+ PE +LG IAV++V+
Sbjct: 116 RTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVR 175
Query: 270 GLTYLWS-LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPER 327
L +L S L ++HRDVKPSN+L+N G VK+CDFG+S LV+S+AKT G YMAPER
Sbjct: 176 ALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPER 235
Query: 328 ISGE----QYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVL 383
I+ E Y + SDVWSLGI+ +E+A+ RFPY ++ G+ P Q L+ +V+E SP L
Sbjct: 236 INPELNQKGYNVKSDVWSLGITMIEMAILRFPY----ESWGT--PFQQLKQVVEEPSPQL 289
Query: 384 PVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPF 418
P FS FV F QC+RK P ER + ELM HPF
Sbjct: 290 PADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPF 324
>gi|4506889 mitogen-activated protein kinase kinase 4 [Homo sapiens]
Length = 399
Score = 205 bits (522), Expect = 6e-53
Identities = 125/304 (41%), Positives = 178/304 (58%), Gaps = 27/304 (8%)
Query: 164 QDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSS 222
+D++ +G G G+V K H PSG+I+AVK I + + QKQ++ +L+++ + D
Sbjct: 100 EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCP 159
Query: 223 YIIGFYGAFFVENRISICTEFMDGGSLDVYRK---------MPEHVLGRIAVAVVKGLTY 273
YI+ FYGA F E IC E M S D + K +PE +LG+I +A VK L +
Sbjct: 160 YIVQFYGALFREGDCWICMELMST-SFDKFYKYVYSVLDDVIPEEILGKITLATVKALNH 218
Query: 274 LW-SLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPERI--- 328
L +LKI+HRD+KPSN+L++ G +KLCDFG+S QLV+SIAKT G YMAPERI
Sbjct: 219 LKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPS 278
Query: 329 -SGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVG- 386
S + Y + SDVWSLGI+ ELA GRFPYP+ L +V D P L
Sbjct: 279 ASRQGYDVRSDVWSLGITLYELATGRFPYPKWNS------VFDQLTQVVKGDPPQLSNSE 332
Query: 387 --EFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVCRALEERRSQ 444
EFS F++F+ C+ K +RP +EL+ HPFI+ + + A V+ +VC+ L++ +
Sbjct: 333 EREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEE-RAVEVACYVCKILDQMPAT 391
Query: 445 QGPP 448
P
Sbjct: 392 PSSP 395
>gi|21735544 mitogen-activated protein kinase kinase 7 [Homo
sapiens]
Length = 419
Score = 169 bits (429), Expect = 4e-42
Identities = 114/322 (35%), Positives = 176/322 (54%), Gaps = 25/322 (7%)
Query: 128 PSQHSSPAVSDSLP-SNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGT---VYKA 183
PS +P +S+ L++ + + GQ + +I + LG GT V+K
Sbjct: 78 PSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKM 137
Query: 184 YHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSSYIIGFYGAFFVENRISICTE 242
+G ++AVK + E K+I+ +L+++ K D YI+ +G F + I E
Sbjct: 138 RFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAME 197
Query: 243 FMDGGSLDVYRKM----PEHVLGRIAVAVVKGLTYLWSLK-ILHRDVKPSNMLVNTRGQV 297
M + + ++M PE +LG++ VA+VK L YL ++HRDVKPSN+L++ RGQ+
Sbjct: 198 LMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQI 257
Query: 298 KLCDFGVSTQLVNSIAKT-YVGTNAYMAPERI-----SGEQYGIHSDVWSLGISFMELAL 351
KLCDFG+S +LV+S AKT G AYMAPERI + Y I +DVWSLGIS +ELA
Sbjct: 258 KLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELAT 317
Query: 352 GRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLP--VGEFSEPFVHFITQCMRKQPKERPA 409
G+FPY + + ++L ++ E+ P+LP +G FS F F+ C+ K ++RP
Sbjct: 318 GQFPYKNCKTD------FEVLTKVLQEEPPLLPGHMG-FSGDFQSFVKDCLTKDHRKRPK 370
Query: 410 PEELMGHPFIVQFNDGNAAVVS 431
+L+ H FI ++ V S
Sbjct: 371 YNKLLEHSFIKRYETLEVDVAS 392
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 167 bits (422), Expect = 2e-41
Identities = 96/257 (37%), Positives = 154/257 (59%), Gaps = 13/257 (5%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYG 229
+ +G G+ G V+K + +++A+K+I L+ + + I E+ +L +CDSSY+ +YG
Sbjct: 28 ERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYG 87
Query: 230 AFFVENRISICTEFMDGGS-LDVYRKMP--EHVLGRIAVAVVKGLTYLWSLKILHRDVKP 286
++ +++ I E++ GGS LD+ R P E + + ++KGL YL S K +HRD+K
Sbjct: 88 SYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKA 147
Query: 287 SNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQYGIHSDVWSLGI 344
+N+L++ +G VKL DFGV+ QL ++ K T+VGT +MAPE I Y +D+WSLGI
Sbjct: 148 ANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGI 207
Query: 345 SFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQP 404
+ +ELA G P + P+++L I + P L VG+F++ F FI C+ K P
Sbjct: 208 TAIELAKGEPP-------NSDMHPMRVLFLIPKNNPPTL-VGDFTKSFKEFIDACLNKDP 259
Query: 405 KERPAPEELMGHPFIVQ 421
RP +EL+ H FIV+
Sbjct: 260 SFRPTAKELLKHKFIVK 276
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 167 bits (422), Expect = 2e-41
Identities = 94/258 (36%), Positives = 154/258 (59%), Gaps = 13/258 (5%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYG 229
D +G G+ G VYK + +++A+K+I L+ + + I E+ +L +CDS YI ++G
Sbjct: 24 DRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFG 83
Query: 230 AFFVENRISICTEFMDGGS-LDVYRKMP--EHVLGRIAVAVVKGLTYLWSLKILHRDVKP 286
++ ++ I E++ GGS LD+ + P E + I ++KGL YL S + +HRD+K
Sbjct: 84 SYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKA 143
Query: 287 SNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQYGIHSDVWSLGI 344
+N+L++ +G VKL DFGV+ QL ++ K T+VGT +MAPE I Y +D+WSLGI
Sbjct: 144 ANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGI 203
Query: 345 SFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQP 404
+ +ELA G P L P+++L ++ ++SP G+ S+PF F+ C+ K P
Sbjct: 204 TAIELAKGEPP-------NSDLHPMRVL-FLIPKNSPPTLEGQHSKPFKEFVEACLNKDP 255
Query: 405 KERPAPEELMGHPFIVQF 422
+ RP +EL+ H FI ++
Sbjct: 256 RFRPTAKELLKHKFITRY 273
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 166 bits (419), Expect = 5e-41
Identities = 94/257 (36%), Positives = 153/257 (59%), Gaps = 13/257 (5%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYG 229
+ +G G+ G V+K + K++A+K+I L+ + + I E+ +L +CDS Y+ +YG
Sbjct: 28 EKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYG 87
Query: 230 AFFVENRISICTEFMDGGS-LDVYRKMP--EHVLGRIAVAVVKGLTYLWSLKILHRDVKP 286
++ + ++ I E++ GGS LD+ P E + I ++KGL YL S K +HRD+K
Sbjct: 88 SYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKA 147
Query: 287 SNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQYGIHSDVWSLGI 344
+N+L++ G+VKL DFGV+ QL ++ K T+VGT +MAPE I Y +D+WSLGI
Sbjct: 148 ANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGI 207
Query: 345 SFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQP 404
+ +ELA G P+ + L P+++L I + P L G +S+P F+ C+ K+P
Sbjct: 208 TAIELARGEPPHSE-------LHPMKVLFLIPKNNPPTLE-GNYSKPLKEFVEACLNKEP 259
Query: 405 KERPAPEELMGHPFIVQ 421
RP +EL+ H FI++
Sbjct: 260 SFRPTAKELLKHKFILR 276
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 166 bits (419), Expect = 5e-41
Identities = 94/257 (36%), Positives = 153/257 (59%), Gaps = 13/257 (5%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYG 229
+ +G G+ G V+K + K++A+K+I L+ + + I E+ +L +CDS Y+ +YG
Sbjct: 40 EKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYG 99
Query: 230 AFFVENRISICTEFMDGGS-LDVYRKMP--EHVLGRIAVAVVKGLTYLWSLKILHRDVKP 286
++ + ++ I E++ GGS LD+ P E + I ++KGL YL S K +HRD+K
Sbjct: 100 SYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKA 159
Query: 287 SNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQYGIHSDVWSLGI 344
+N+L++ G+VKL DFGV+ QL ++ K T+VGT +MAPE I Y +D+WSLGI
Sbjct: 160 ANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGI 219
Query: 345 SFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQP 404
+ +ELA G P+ + L P+++L I + P L G +S+P F+ C+ K+P
Sbjct: 220 TAIELARGEPPHSE-------LHPMKVLFLIPKNNPPTLE-GNYSKPLKEFVEACLNKEP 271
Query: 405 KERPAPEELMGHPFIVQ 421
RP +EL+ H FI++
Sbjct: 272 SFRPTAKELLKHKFILR 288
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 165 bits (418), Expect = 7e-41
Identities = 98/287 (34%), Positives = 163/287 (56%), Gaps = 23/287 (8%)
Query: 141 PSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLD 200
P + LKK S + + + E+ + LG G+ G+V+KA H SG+++A+K + ++
Sbjct: 7 PKSKLKKLSED-----SLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE 61
Query: 201 ITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSL-DVYR----KM 255
L+ +I+ E+ I+ +CDS Y++ +YG++F + I E+ GS+ D+ R +
Sbjct: 62 SDLQ---EIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTL 118
Query: 256 PEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK- 314
E + I + +KGL YL ++ +HRD+K N+L+NT G KL DFGV+ QL +++AK
Sbjct: 119 IEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKR 178
Query: 315 -TYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQ 373
T +GT +MAPE I Y +D+WSLGI+ +E+A G+ PY I P++ +
Sbjct: 179 NTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIH-------PMRAIF 231
Query: 374 CIVDEDSPVLPVGE-FSEPFVHFITQCMRKQPKERPAPEELMGHPFI 419
I P E +S+ F F+ +C+ K P++R +L+ HPFI
Sbjct: 232 MIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFI 278
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 164 bits (416), Expect = 1e-40
Identities = 92/258 (35%), Positives = 152/258 (58%), Gaps = 18/258 (6%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYG 229
+ LG G+ G+VYKA H +G+I+A+K + ++ L+ +I+ E+ I+ +CDS +++ +YG
Sbjct: 34 EKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQ---EIIKEISIMQQCDSPHVVKYYG 90
Query: 230 AFFVENRISICTEFMDGGSL-DVYR----KMPEHVLGRIAVAVVKGLTYLWSLKILHRDV 284
++F + I E+ GS+ D+ R + E + I + +KGL YL ++ +HRD+
Sbjct: 91 SYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDI 150
Query: 285 KPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQYGIHSDVWSL 342
K N+L+NT G KL DFGV+ QL +++AK T +GT +MAPE I Y +D+WSL
Sbjct: 151 KAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSL 210
Query: 343 GISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGE-FSEPFVHFITQCMR 401
GI+ +E+A G+ PY I P++ + I P E +S+ F F+ QC+
Sbjct: 211 GITAIEMAEGKPPYADIH-------PMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLV 263
Query: 402 KQPKERPAPEELMGHPFI 419
K P++R +L+ HPF+
Sbjct: 264 KSPEQRATATQLLQHPFV 281
>gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens]
Length = 353
Score = 150 bits (379), Expect = 2e-36
Identities = 89/202 (44%), Positives = 120/202 (59%), Gaps = 14/202 (6%)
Query: 158 NGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEI-L 216
N ++ D+ LG G G V K H SG I+AVK+I + QK+++ +L+I +
Sbjct: 61 NFEVEADDLVTIPELGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDLDINM 120
Query: 217 YKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKM-------PEHVLGRIAVAVVK 269
D Y + FYGA F E + IC E MD YRK+ PE +LG IAV++V+
Sbjct: 121 RTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVR 180
Query: 270 GLTYLWS-LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPER 327
L +L S L ++HRDVKPSN+L+N G VK+CDFG+S LV+S+AK G YMAPER
Sbjct: 181 ALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMDAGCKPYMAPER 240
Query: 328 ISGE----QYGIHSDVWSLGIS 345
I+ E Y + SDVWSLGI+
Sbjct: 241 INPELNQKGYNVKSDVWSLGIT 262
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 142 bits (359), Expect = 5e-34
Identities = 88/271 (32%), Positives = 152/271 (56%), Gaps = 20/271 (7%)
Query: 163 EQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSS 222
++D +G G G VYKA +V +G++ A+KVI L+ + + E+ ++ C
Sbjct: 13 QEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV-VQQEIIMMKDCKHP 71
Query: 223 YIIGFYGAFFVENRISICTEFMDGGSL-DVYR---KMPEHVLGRIAVAVVKGLTYLWSLK 278
I+ ++G++ +++ IC EF GGSL D+Y + E + ++ ++GL YL S
Sbjct: 72 NIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKG 131
Query: 279 ILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIA--KTYVGTNAYMAPERISGEQYGIH 336
+HRD+K +N+L+ G VKL DFGVS Q+ +IA K+++GT +MAPE + E+ G +
Sbjct: 132 KMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGY 191
Query: 337 S---DVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVD---EDSPVLPVGEFSE 390
+ D+W++GI+ +ELA ++Q L P++ L + + + ++S
Sbjct: 192 NQLCDLWAVGITAIELA-------ELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSN 244
Query: 391 PFVHFITQCMRKQPKERPAPEELMGHPFIVQ 421
F HF+ + K PK+RP E+L+ HPF+ Q
Sbjct: 245 SFHHFVKMALTKNPKKRPTAEKLLQHPFVTQ 275
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 141 bits (356), Expect = 1e-33
Identities = 92/270 (34%), Positives = 149/270 (55%), Gaps = 29/270 (10%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIG-FY 228
+ +G+G G VYK HV +G++ A+KV +D+T + +++I E+ +L K I +Y
Sbjct: 29 ELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNIATYY 86
Query: 229 GAFFVEN------RISICTEFMDGGSLDVYRK------MPEHVLGRIAVAVVKGLTYLWS 276
GAF +N ++ + EF GS+ K + E + I +++GL++L
Sbjct: 87 GAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 277 LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQ-- 332
K++HRD+K N+L+ +VKL DFGVS QL ++ + T++GT +MAPE I+ ++
Sbjct: 147 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 206
Query: 333 ---YGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFS 389
Y SD+WSLGI+ +E+A G P + P++ L I +P L ++S
Sbjct: 207 DATYDFKSDLWSLGITAIEMAEGAPPLCDMH-------PMRALFLIPRNPAPRLKSKKWS 259
Query: 390 EPFVHFITQCMRKQPKERPAPEELMGHPFI 419
+ F FI C+ K +RPA E+LM HPFI
Sbjct: 260 KKFQSFIESCLVKNHSQRPATEQLMKHPFI 289
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 141 bits (356), Expect = 1e-33
Identities = 92/270 (34%), Positives = 149/270 (55%), Gaps = 29/270 (10%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIG-FY 228
+ +G+G G VYK HV +G++ A+KV +D+T + +++I E+ +L K I +Y
Sbjct: 29 ELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNIATYY 86
Query: 229 GAFFVEN------RISICTEFMDGGSLDVYRK------MPEHVLGRIAVAVVKGLTYLWS 276
GAF +N ++ + EF GS+ K + E + I +++GL++L
Sbjct: 87 GAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 277 LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQ-- 332
K++HRD+K N+L+ +VKL DFGVS QL ++ + T++GT +MAPE I+ ++
Sbjct: 147 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 206
Query: 333 ---YGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFS 389
Y SD+WSLGI+ +E+A G P + P++ L I +P L ++S
Sbjct: 207 DATYDFKSDLWSLGITAIEMAEGAPPLCDMH-------PMRALFLIPRNPAPRLKSKKWS 259
Query: 390 EPFVHFITQCMRKQPKERPAPEELMGHPFI 419
+ F FI C+ K +RPA E+LM HPFI
Sbjct: 260 KKFQSFIESCLVKNHSQRPATEQLMKHPFI 289
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 141 bits (356), Expect = 1e-33
Identities = 92/270 (34%), Positives = 149/270 (55%), Gaps = 29/270 (10%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIG-FY 228
+ +G+G G VYK HV +G++ A+KV +D+T + +++I E+ +L K I +Y
Sbjct: 29 ELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNIATYY 86
Query: 229 GAFFVEN------RISICTEFMDGGSLDVYRK------MPEHVLGRIAVAVVKGLTYLWS 276
GAF +N ++ + EF GS+ K + E + I +++GL++L
Sbjct: 87 GAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 277 LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQ-- 332
K++HRD+K N+L+ +VKL DFGVS QL ++ + T++GT +MAPE I+ ++
Sbjct: 147 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 206
Query: 333 ---YGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFS 389
Y SD+WSLGI+ +E+A G P + P++ L I +P L ++S
Sbjct: 207 DATYDFKSDLWSLGITAIEMAEGAPPLCDMH-------PMRALFLIPRNPAPRLKSKKWS 259
Query: 390 EPFVHFITQCMRKQPKERPAPEELMGHPFI 419
+ F FI C+ K +RPA E+LM HPFI
Sbjct: 260 KKFQSFIESCLVKNHSQRPATEQLMKHPFI 289
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 141 bits (356), Expect = 1e-33
Identities = 92/270 (34%), Positives = 149/270 (55%), Gaps = 29/270 (10%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIG-FY 228
+ +G+G G VYK HV +G++ A+KV +D+T + +++I E+ +L K I +Y
Sbjct: 29 ELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNIATYY 86
Query: 229 GAFFVEN------RISICTEFMDGGSLDVYRK------MPEHVLGRIAVAVVKGLTYLWS 276
GAF +N ++ + EF GS+ K + E + I +++GL++L
Sbjct: 87 GAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 277 LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQ-- 332
K++HRD+K N+L+ +VKL DFGVS QL ++ + T++GT +MAPE I+ ++
Sbjct: 147 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 206
Query: 333 ---YGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFS 389
Y SD+WSLGI+ +E+A G P + P++ L I +P L ++S
Sbjct: 207 DATYDFKSDLWSLGITAIEMAEGAPPLCDMH-------PMRALFLIPRNPAPRLKSKKWS 259
Query: 390 EPFVHFITQCMRKQPKERPAPEELMGHPFI 419
+ F FI C+ K +RPA E+LM HPFI
Sbjct: 260 KKFQSFIESCLVKNHSQRPATEQLMKHPFI 289
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 141 bits (356), Expect = 1e-33
Identities = 92/270 (34%), Positives = 149/270 (55%), Gaps = 29/270 (10%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIG-FY 228
+ +G+G G VYK HV +G++ A+KV +D+T + +++I E+ +L K I +Y
Sbjct: 29 ELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNIATYY 86
Query: 229 GAFFVEN------RISICTEFMDGGSLDVYRK------MPEHVLGRIAVAVVKGLTYLWS 276
GAF +N ++ + EF GS+ K + E + I +++GL++L
Sbjct: 87 GAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 277 LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQ-- 332
K++HRD+K N+L+ +VKL DFGVS QL ++ + T++GT +MAPE I+ ++
Sbjct: 147 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 206
Query: 333 ---YGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFS 389
Y SD+WSLGI+ +E+A G P + P++ L I +P L ++S
Sbjct: 207 DATYDFKSDLWSLGITAIEMAEGAPPLCDMH-------PMRALFLIPRNPAPRLKSKKWS 259
Query: 390 EPFVHFITQCMRKQPKERPAPEELMGHPFI 419
+ F FI C+ K +RPA E+LM HPFI
Sbjct: 260 KKFQSFIESCLVKNHSQRPATEQLMKHPFI 289
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 141 bits (356), Expect = 1e-33
Identities = 92/270 (34%), Positives = 149/270 (55%), Gaps = 29/270 (10%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIG-FY 228
+ +G+G G VYK HV +G++ A+KV +D+T + +++I E+ +L K I +Y
Sbjct: 29 ELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNIATYY 86
Query: 229 GAFFVEN------RISICTEFMDGGSLDVYRK------MPEHVLGRIAVAVVKGLTYLWS 276
GAF +N ++ + EF GS+ K + E + I +++GL++L
Sbjct: 87 GAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 277 LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQ-- 332
K++HRD+K N+L+ +VKL DFGVS QL ++ + T++GT +MAPE I+ ++
Sbjct: 147 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 206
Query: 333 ---YGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFS 389
Y SD+WSLGI+ +E+A G P + P++ L I +P L ++S
Sbjct: 207 DATYDFKSDLWSLGITAIEMAEGAPPLCDMH-------PMRALFLIPRNPAPRLKSKKWS 259
Query: 390 EPFVHFITQCMRKQPKERPAPEELMGHPFI 419
+ F FI C+ K +RPA E+LM HPFI
Sbjct: 260 KKFQSFIESCLVKNHSQRPATEQLMKHPFI 289
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 141 bits (356), Expect = 1e-33
Identities = 92/270 (34%), Positives = 149/270 (55%), Gaps = 29/270 (10%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIG-FY 228
+ +G+G G VYK HV +G++ A+KV +D+T + +++I E+ +L K I +Y
Sbjct: 29 ELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNIATYY 86
Query: 229 GAFFVEN------RISICTEFMDGGSLDVYRK------MPEHVLGRIAVAVVKGLTYLWS 276
GAF +N ++ + EF GS+ K + E + I +++GL++L
Sbjct: 87 GAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 277 LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQ-- 332
K++HRD+K N+L+ +VKL DFGVS QL ++ + T++GT +MAPE I+ ++
Sbjct: 147 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 206
Query: 333 ---YGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFS 389
Y SD+WSLGI+ +E+A G P + P++ L I +P L ++S
Sbjct: 207 DATYDFKSDLWSLGITAIEMAEGAPPLCDMH-------PMRALFLIPRNPAPRLKSKKWS 259
Query: 390 EPFVHFITQCMRKQPKERPAPEELMGHPFI 419
+ F FI C+ K +RPA E+LM HPFI
Sbjct: 260 KKFQSFIESCLVKNHSQRPATEQLMKHPFI 289
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 141 bits (356), Expect = 1e-33
Identities = 92/270 (34%), Positives = 149/270 (55%), Gaps = 29/270 (10%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIG-FY 228
+ +G+G G VYK HV +G++ A+KV +D+T + +++I E+ +L K I +Y
Sbjct: 29 ELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNIATYY 86
Query: 229 GAFFVEN------RISICTEFMDGGSLDVYRK------MPEHVLGRIAVAVVKGLTYLWS 276
GAF +N ++ + EF GS+ K + E + I +++GL++L
Sbjct: 87 GAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 277 LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQ-- 332
K++HRD+K N+L+ +VKL DFGVS QL ++ + T++GT +MAPE I+ ++
Sbjct: 147 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 206
Query: 333 ---YGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFS 389
Y SD+WSLGI+ +E+A G P + P++ L I +P L ++S
Sbjct: 207 DATYDFKSDLWSLGITAIEMAEGAPPLCDMH-------PMRALFLIPRNPAPRLKSKKWS 259
Query: 390 EPFVHFITQCMRKQPKERPAPEELMGHPFI 419
+ F FI C+ K +RPA E+LM HPFI
Sbjct: 260 KKFQSFIESCLVKNHSQRPATEQLMKHPFI 289
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 141 bits (355), Expect = 1e-33
Identities = 89/269 (33%), Positives = 145/269 (53%), Gaps = 21/269 (7%)
Query: 172 LGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAF 231
LG G G VYKA + +G + A KVI EL+ I+ E+EIL CD YI+ GA+
Sbjct: 42 LGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIV-EIEILATCDHPYIVKLLGAY 100
Query: 232 FVENRISICTEFMDGGSLDVY-----RKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKP 286
+ + ++ I EF GG++D R + E + + +++ L +L S +I+HRD+K
Sbjct: 101 YHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKA 160
Query: 287 SNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGE-----QYGIHSDV 339
N+L+ G ++L DFGVS + + ++ K +++GT +MAPE + E Y +D+
Sbjct: 161 GNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADI 220
Query: 340 WSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSP-VLPVGEFSEPFVHFITQ 398
WSLGI+ +E+A QI+ L P+++L I D P +L ++S F F+
Sbjct: 221 WSLGITLIEMA-------QIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKI 273
Query: 399 CMRKQPKERPAPEELMGHPFIVQFNDGNA 427
+ K P+ RP+ +L+ HPF+ A
Sbjct: 274 ALDKNPETRPSAAQLLEHPFVSSITSNKA 302
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 135 bits (341), Expect = 6e-32
Identities = 86/262 (32%), Positives = 145/262 (55%), Gaps = 20/262 (7%)
Query: 172 LGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAF 231
+G G G VYKA + ++ AVK++ LD ++ + E+ IL +C ++ + G++
Sbjct: 22 VGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISS-LQQEITILRECRHPNVVAYIGSY 80
Query: 232 FVENRISICTEFMDGGSL-DVYRK---MPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPS 287
+R+ IC EF GGSL ++Y + E + + +KGL +L S +HRD+K +
Sbjct: 81 LRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHSQGKIHRDIKGA 140
Query: 288 NMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQYGIHS---DVWSL 342
N+L+ +G VKL DFGVS +L S+AK +++GT +MAPE + E+ G ++ DVW+L
Sbjct: 141 NLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWAL 200
Query: 343 GISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVD---EDSPVLPVGEFSEPFVHFITQC 399
GI+ +EL ++Q L P++ L + + + +++ F HF+
Sbjct: 201 GITAIELG-------ELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLA 253
Query: 400 MRKQPKERPAPEELMGHPFIVQ 421
+ K PK+RP E+L+ HPF Q
Sbjct: 254 LTKNPKKRPTAEKLLQHPFTTQ 275
>gi|4826878 oxidative-stress responsive 1 [Homo sapiens]
Length = 527
Score = 134 bits (336), Expect = 2e-31
Identities = 84/286 (29%), Positives = 142/286 (49%), Gaps = 35/286 (12%)
Query: 161 MNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCD 220
+N D ++ +G G V AY P + +A+K I L+ +++ E++ + +C
Sbjct: 12 INRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCH 71
Query: 221 SSYIIGFYGAFFVENRISICTEFMDGGS-LDVYRK-----------MPEHVLGRIAVAVV 268
I+ +Y +F V++ + + + + GGS LD+ + + E + I V+
Sbjct: 72 HPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVL 131
Query: 269 KGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLV-------NSIAKTYVGTNA 321
+GL YL +HRDVK N+L+ G V++ DFGVS L N + KT+VGT
Sbjct: 132 EGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPC 191
Query: 322 YMAPERISGEQ-YGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDS 380
+MAPE + + Y +D+WS GI+ +ELA G PY + P+++L + D
Sbjct: 192 WMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYP-------PMKVLMLTLQNDP 244
Query: 381 PVLPVG--------EFSEPFVHFITQCMRKQPKERPAPEELMGHPF 418
P L G ++ + F I+ C++K P++RP EL+ H F
Sbjct: 245 PSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKF 290
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 134 bits (336), Expect = 2e-31
Identities = 88/270 (32%), Positives = 146/270 (54%), Gaps = 29/270 (10%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIG-FY 228
+ +G+G G VYK HV +G++ A+KV +D+T + +++I E+ +L K I +Y
Sbjct: 29 EVVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTEDEEEEIKQEINMLKKYSHHRNIATYY 86
Query: 229 GAFFV------ENRISICTEFMDGGSLDVYRK------MPEHVLGRIAVAVVKGLTYLWS 276
GAF ++++ + EF GS+ K + E + I +++GL +L +
Sbjct: 87 GAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHA 146
Query: 277 LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQ-- 332
K++HRD+K N+L+ +VKL DFGVS QL ++ + T++GT +MAPE I+ ++
Sbjct: 147 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 206
Query: 333 ---YGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFS 389
Y SD+WSLGI+ +E+A G P + P++ L I P L ++S
Sbjct: 207 DATYDYRSDIWSLGITAIEMAEGAPPLCDMH-------PMRALFLIPRNPPPRLKSKKWS 259
Query: 390 EPFVHFITQCMRKQPKERPAPEELMGHPFI 419
+ F+ FI C+ K RP E+L+ PFI
Sbjct: 260 KKFIDFIDTCLIKTYLSRPPTEQLLKFPFI 289
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 134 bits (336), Expect = 2e-31
Identities = 88/270 (32%), Positives = 146/270 (54%), Gaps = 29/270 (10%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIG-FY 228
+ +G+G G VYK HV +G++ A+KV +D+T + +++I E+ +L K I +Y
Sbjct: 29 EVVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTEDEEEEIKQEINMLKKYSHHRNIATYY 86
Query: 229 GAFFV------ENRISICTEFMDGGSLDVYRK------MPEHVLGRIAVAVVKGLTYLWS 276
GAF ++++ + EF GS+ K + E + I +++GL +L +
Sbjct: 87 GAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHA 146
Query: 277 LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQ-- 332
K++HRD+K N+L+ +VKL DFGVS QL ++ + T++GT +MAPE I+ ++
Sbjct: 147 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 206
Query: 333 ---YGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFS 389
Y SD+WSLGI+ +E+A G P + P++ L I P L ++S
Sbjct: 207 DATYDYRSDIWSLGITAIEMAEGAPPLCDMH-------PMRALFLIPRNPPPRLKSKKWS 259
Query: 390 EPFVHFITQCMRKQPKERPAPEELMGHPFI 419
+ F+ FI C+ K RP E+L+ PFI
Sbjct: 260 KKFIDFIDTCLIKTYLSRPPTEQLLKFPFI 289
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,322,965
Number of Sequences: 37866
Number of extensions: 842644
Number of successful extensions: 3949
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 702
Number of HSP's successfully gapped in prelim test: 94
Number of HSP's that attempted gapping in prelim test: 1740
Number of HSP's gapped (non-prelim): 937
length of query: 448
length of database: 18,247,518
effective HSP length: 106
effective length of query: 342
effective length of database: 14,233,722
effective search space: 4867932924
effective search space used: 4867932924
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.