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Search of human proteins with 217272804
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|217272804 hyaluronan-mediated motility receptor isoform d
[Homo sapiens]
(638 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho... 1217 0.0
gi|217272802 hyaluronan-mediated motility receptor isoform a [Ho... 1211 0.0
gi|217416398 hyaluronan-mediated motility receptor isoform c [Ho... 1211 0.0
gi|217416394 hyaluronan-mediated motility receptor isoform b [Ho... 1211 0.0
gi|9910266 kinesin family member 15 [Homo sapiens] 129 8e-30
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 123 6e-28
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 123 6e-28
gi|156104908 myosin heavy chain 6 [Homo sapiens] 122 1e-27
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 121 2e-27
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 120 4e-27
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 119 9e-27
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 119 9e-27
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 117 3e-26
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 117 4e-26
gi|38044112 restin isoform b [Homo sapiens] 117 4e-26
gi|4506751 restin isoform a [Homo sapiens] 117 4e-26
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 116 7e-26
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 116 7e-26
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 114 2e-25
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 114 2e-25
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 114 4e-25
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 112 1e-24
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 112 1e-24
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 111 2e-24
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 111 2e-24
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 110 3e-24
gi|31982906 cingulin-like 1 [Homo sapiens] 110 5e-24
gi|21735548 centrosomal protein 2 [Homo sapiens] 109 7e-24
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 109 9e-24
gi|34577114 cytomatrix protein p110 [Homo sapiens] 108 2e-23
>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
sapiens]
Length = 638
Score = 1217 bits (3150), Expect = 0.0
Identities = 638/638 (100%), Positives = 638/638 (100%)
Query: 1 MTLLIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRT 60
MTLLIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRT
Sbjct: 1 MTLLIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRT 60
Query: 61 NELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQ 120
NELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQ
Sbjct: 61 NELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQ 120
Query: 121 GKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND 180
GKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND
Sbjct: 121 GKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND 180
Query: 181 EILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFI 240
EILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFI
Sbjct: 181 EILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFI 240
Query: 241 LEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD 300
LEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD
Sbjct: 241 LEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD 300
Query: 301 KLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYD 360
KLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYD
Sbjct: 301 KLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYD 360
Query: 361 SMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQ 420
SMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQ
Sbjct: 361 SMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQ 420
Query: 421 EYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKE 480
EYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKE
Sbjct: 421 EYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKE 480
Query: 481 NTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYA 540
NTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYA
Sbjct: 481 NTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYA 540
Query: 541 KLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFD 600
KLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFD
Sbjct: 541 KLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFD 600
Query: 601 PSKAFHHESKENFALKTPLKEGNTNCYRAPMECQESWK 638
PSKAFHHESKENFALKTPLKEGNTNCYRAPMECQESWK
Sbjct: 601 PSKAFHHESKENFALKTPLKEGNTNCYRAPMECQESWK 638
>gi|217272802 hyaluronan-mediated motility receptor isoform a [Homo
sapiens]
Length = 725
Score = 1211 bits (3132), Expect = 0.0
Identities = 634/634 (100%), Positives = 634/634 (100%)
Query: 5 IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL 64
IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL
Sbjct: 92 IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL 151
Query: 65 KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA 124
KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA
Sbjct: 152 KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA 211
Query: 125 QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 184
QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS
Sbjct: 212 QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 271
Query: 185 LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ 244
LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ
Sbjct: 272 LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ 331
Query: 245 EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQ 304
EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQ
Sbjct: 332 EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQ 391
Query: 305 KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 364
KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ
Sbjct: 392 KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 451
Query: 365 SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR 424
SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR
Sbjct: 452 SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR 511
Query: 425 MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA 484
MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA
Sbjct: 512 MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA 571
Query: 485 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG 544
ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG
Sbjct: 572 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG 631
Query: 545 HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKA 604
HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKA
Sbjct: 632 HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKA 691
Query: 605 FHHESKENFALKTPLKEGNTNCYRAPMECQESWK 638
FHHESKENFALKTPLKEGNTNCYRAPMECQESWK
Sbjct: 692 FHHESKENFALKTPLKEGNTNCYRAPMECQESWK 725
Score = 64.7 bits (156), Expect = 2e-10
Identities = 103/467 (22%), Positives = 191/467 (40%), Gaps = 99/467 (21%)
Query: 206 KCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKF-------------ILEQQEREKLQQK 252
K Q +++KE N N + + L A + +K ILE++ R LQ++
Sbjct: 40 KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQER 99
Query: 253 ELQ-------IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFE-----EELKQTLD--- 297
Q L + E L+++L +K EK L E E LK
Sbjct: 100 GAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENG 159
Query: 298 ----------ELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAA 347
EL KL+ K E R + +E + + + + E+ +GK A+LE +
Sbjct: 160 NQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVS 219
Query: 348 HTQATLLLQEKYDSMVQSLEDVTA---QFESYKALTASEIEDLKLEN-------SSLQEK 397
+ + + + + +++ +E+++ Q E YK A E+LK +N SL+E
Sbjct: 220 IEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEEN 279
Query: 398 AAKAGKNAEDVQHQILATESSNQEYV-------------------RMLLDLQTKSALKET 438
K ED+ + E +++V + +L+ Q + L++
Sbjct: 280 IVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK 339
Query: 439 EI---------KEITVSFLQKITDLQNQLKQQEEDFRKQLE---DEEGRKAEKENTTAEL 486
E+ KE++ S QK+ Q ++ +++ F ++L+ DE + +KE L
Sbjct: 340 ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 399
Query: 487 TEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQ 546
++ L EE ++ + +L L+ K+A L + AA Q A LL
Sbjct: 400 VKQ------LEEEAKSRAEELKL-LEEKLKGKEAELEKSSAAHTQ--------ATLL--- 441
Query: 547 NLKQKIKHVVK-LKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNK 592
L++K +V+ L+D +Q +S + ++ K + LQE+ K
Sbjct: 442 -LQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAK 487
Score = 46.2 bits (108), Expect = 9e-05
Identities = 73/357 (20%), Positives = 152/357 (42%), Gaps = 46/357 (12%)
Query: 272 QKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAE-----RLVKQLEEEAKSRAEE 326
QK F+++ ++NL ++ K++ E + E + +K LE+E + +E
Sbjct: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQE 98
Query: 327 LKLLEEKLKGKEAELEKS----SAAHTQATLL------LQEKYDSMVQSLEDVTAQFE-- 374
+ +++ E ELEK +AA + T L L+++ + ++ E + ++F
Sbjct: 99 RGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN 158
Query: 375 -SYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQ--- 430
+ K L +E +KL N + K E ++ ++ T+ S +E + L+
Sbjct: 159 GNQKNLRILSLELMKLRNKRETKMRGMMAKQ-EGMEMKLQVTQRSLEESQGKIAQLEGKL 217
Query: 431 ---TKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELT 487
K + E E + ++++I+ +Q+++ + D A+ E E
Sbjct: 218 VSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDI-----------AQLEENLKEKN 266
Query: 488 EEINKWRLLYEE----LYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLN-KIRDSYAKL 542
+EI + EE L + + ++ E EK+ +N + E LN ++++ K
Sbjct: 267 DEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKF 326
Query: 543 LGHQ----NLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKL-QEELNKVL 594
+ Q L+QK + L + +L S + + C ++ E L +EEL + L
Sbjct: 327 ILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL 383
>gi|217416398 hyaluronan-mediated motility receptor isoform c [Homo
sapiens]
Length = 709
Score = 1211 bits (3132), Expect = 0.0
Identities = 634/634 (100%), Positives = 634/634 (100%)
Query: 5 IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL 64
IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL
Sbjct: 76 IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL 135
Query: 65 KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA 124
KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA
Sbjct: 136 KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA 195
Query: 125 QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 184
QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS
Sbjct: 196 QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 255
Query: 185 LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ 244
LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ
Sbjct: 256 LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ 315
Query: 245 EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQ 304
EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQ
Sbjct: 316 EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQ 375
Query: 305 KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 364
KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ
Sbjct: 376 KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 435
Query: 365 SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR 424
SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR
Sbjct: 436 SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR 495
Query: 425 MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA 484
MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA
Sbjct: 496 MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA 555
Query: 485 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG 544
ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG
Sbjct: 556 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG 615
Query: 545 HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKA 604
HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKA
Sbjct: 616 HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKA 675
Query: 605 FHHESKENFALKTPLKEGNTNCYRAPMECQESWK 638
FHHESKENFALKTPLKEGNTNCYRAPMECQESWK
Sbjct: 676 FHHESKENFALKTPLKEGNTNCYRAPMECQESWK 709
>gi|217416394 hyaluronan-mediated motility receptor isoform b [Homo
sapiens]
Length = 724
Score = 1211 bits (3132), Expect = 0.0
Identities = 634/634 (100%), Positives = 634/634 (100%)
Query: 5 IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL 64
IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL
Sbjct: 91 IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL 150
Query: 65 KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA 124
KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA
Sbjct: 151 KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA 210
Query: 125 QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 184
QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS
Sbjct: 211 QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 270
Query: 185 LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ 244
LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ
Sbjct: 271 LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ 330
Query: 245 EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQ 304
EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQ
Sbjct: 331 EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQ 390
Query: 305 KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 364
KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ
Sbjct: 391 KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 450
Query: 365 SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR 424
SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR
Sbjct: 451 SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR 510
Query: 425 MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA 484
MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA
Sbjct: 511 MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA 570
Query: 485 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG 544
ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG
Sbjct: 571 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG 630
Query: 545 HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKA 604
HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKA
Sbjct: 631 HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKA 690
Query: 605 FHHESKENFALKTPLKEGNTNCYRAPMECQESWK 638
FHHESKENFALKTPLKEGNTNCYRAPMECQESWK
Sbjct: 691 FHHESKENFALKTPLKEGNTNCYRAPMECQESWK 724
Score = 48.1 bits (113), Expect = 2e-05
Identities = 74/356 (20%), Positives = 155/356 (43%), Gaps = 45/356 (12%)
Query: 272 QKLCSFQEEMVKEKNLFEEE---LKQTLDELDKLQQKEEQA-ERLVKQLEEEAKSRAEEL 327
QK F+++ ++NL ++ L + ++ + KE Q ++ +K LE+E + +E
Sbjct: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQER 98
Query: 328 KLLEEKLKGKEAELEKS----SAAHTQATLL------LQEKYDSMVQSLEDVTAQFE--- 374
+ +++ E ELEK +AA + T L L+++ + ++ E + ++F
Sbjct: 99 GAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENG 158
Query: 375 SYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQ---- 430
+ K L +E +KL N + K E ++ ++ T+ S +E + L+
Sbjct: 159 NQKNLRILSLELMKLRNKRETKMRGMMAKQ-EGMEMKLQVTQRSLEESQGKIAQLEGKLV 217
Query: 431 --TKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTE 488
K + E E + ++++I+ +Q+++ + D A+ E E +
Sbjct: 218 SIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDI-----------AQLEENLKEKND 266
Query: 489 EINKWRLLYEE----LYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLN-KIRDSYAKLL 543
EI + EE L + + ++ E EK+ +N + E LN ++++ K +
Sbjct: 267 EILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFI 326
Query: 544 GHQ----NLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKL-QEELNKVL 594
Q L+QK + L + +L S + + C ++ E L +EEL + L
Sbjct: 327 LEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL 382
>gi|9910266 kinesin family member 15 [Homo sapiens]
Length = 1388
Score = 129 bits (324), Expect = 8e-30
Identities = 145/656 (22%), Positives = 291/656 (44%), Gaps = 105/656 (16%)
Query: 18 RIQDLETELEKM--EARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSE----- 70
+++ T+++++ R++ +++ LS N LEKQL E N+ LKS+ +
Sbjct: 749 KLEHHSTQMQELFSSERIDWTKQQEELLSQLNV-LEKQLQETQTKNDFLKSEVHDLRVVL 807
Query: 71 NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKL---QVTQRSLEESQG------ 121
+ K L + LE + +E + + + ++++L ++ L ES+
Sbjct: 808 HSADKELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSY 867
Query: 122 ---------KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLE 172
+I QL L + +KE KS+ L+E +E +++ KL + Q E
Sbjct: 868 DNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLE-----AEKERNNKLSL-QFE 921
Query: 173 ENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK-----EKE-DHVNRNREHNE 226
E+ + + EIL + +++ + + + E K Q LE+ EK + ++R+ ++
Sbjct: 922 EDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDK 981
Query: 227 NLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVK--- 283
+ A++ N Q+ R + +K ID+L Q+ K+++ + L +E V
Sbjct: 982 KVVADLMNQIQEL------RTSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKK 1035
Query: 284 ---------------------EKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKS 322
E+++ E+L ++L+ L + ++ L++ +EE
Sbjct: 1036 QEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTK 1095
Query: 323 RAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLED--VTAQFESYKA-- 378
+ ++ L+ KL K+ E+E+ + L+ DS + + F+++ A
Sbjct: 1096 KEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKL 1155
Query: 379 --LTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQT---KS 433
EIED + +SL+ K ++ E +IL + +E + L+ Q K+
Sbjct: 1156 LETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENLRLESQQLIEKN 1215
Query: 434 ALKETEIKEITVSFLQKITDLQN-----QLKQQEEDFRKQ-----------------LED 471
L + ++ +I QK QN QLK ++E+ K+ LE+
Sbjct: 1216 WLLQGQLDDIK---RQKENSDQNHPDNQQLKNEQEESIKERLAKSKIVEEMLKMKADLEE 1272
Query: 472 EEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQ 531
+ KE +T+E+ + + L + + + + + +L+ E++ E ++Q
Sbjct: 1273 VQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERERTSQEMEMLRKQ 1332
Query: 532 LNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQ---LAKKKQSET 584
+ + + KL+GHQNL QKI++VV+LK EN +L E KLR + L +KK+SE+
Sbjct: 1333 VECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLAEETEKLRAENVFLKEKKRSES 1388
Score = 70.9 bits (172), Expect = 3e-12
Identities = 136/640 (21%), Positives = 275/640 (42%), Gaps = 88/640 (13%)
Query: 27 EKMEARLNAALREKTSLSANN-ATLEKQLIELTRTNELLKSK--FSENGNQKNLRILSLE 83
E RL ++ + A A LEK E++ + K++ FS ++ + E
Sbjct: 523 ENRRLRLLEPVKRAQEMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTE 582
Query: 84 LMKLRNKR-ETKMRGMMAKQEGMEMKLQVTQRSLE-ESQGKIAQ-----LEGKLVSIEKE 136
+K + + +T++ +KQE E K +R LE ES+ + Q LE L + +
Sbjct: 583 KLKAQLLQIQTELNN--SKQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKAC 640
Query: 137 KIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVIL 196
K E S+ K+ + E + + + Y+L + + + E+ S +N IL
Sbjct: 641 KRQEVSQLNKI--HAETLKIITTPTKAYQLH----SRPVPKLSPEMGSFGSLYTQNSSIL 694
Query: 197 SKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQI 256
+ + V ++ E+ E R E ++A L+ K E+ + KLQQ ++
Sbjct: 695 DNDILNEPVPPEMNEQAFEAISEELRTVQEQMSA----LQAKLDEEEHKNLKLQQHVDKL 750
Query: 257 DSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQL 316
+ Q +EL SS QEE++ + N+ E++L++T + D L+ + ++
Sbjct: 751 EHHSTQMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSA 810
Query: 317 EEEAKSRAEELKLLEEKLK-GKEAELEKSSAAHTQATL-----------------LLQEK 358
++E S +KL K +E E K S H L LQ+
Sbjct: 811 DKELSS----VKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDS 866
Query: 359 YDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQE--KAAKAGKNAEDVQHQILATE 416
YD++ + ++ Q E E LK + ++L E +A K N +Q + E
Sbjct: 867 YDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFE-EDKE 925
Query: 417 SSNQEYVRML----LDLQTKSALKETEIKEI------------TVSFLQK--------IT 452
+S++E +++L + Q ++A E ++ ++ +S L+K +
Sbjct: 926 NSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVVA 985
Query: 453 DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEI---NKWRLLYE----ELYNKTK 505
DL NQ+++ ++ E + K E ++ + + + R+L + ++ + +
Sbjct: 986 DLMNQIQELRTSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKE 1045
Query: 506 PFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL 565
+L++ + ++E+ L + A EQLN + ++ K H L Q ++E ++
Sbjct: 1046 TLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKK---HSGLLQ------SAQEELTKK 1096
Query: 566 KSEVSKLRCQLAKKKQSETKLQEELN-KVLGIKHFDPSKA 604
++ + +L+ +L +KK+ + + E N K+ ++H S A
Sbjct: 1097 EALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAA 1136
Score = 39.7 bits (91), Expect = 0.009
Identities = 98/483 (20%), Positives = 191/483 (39%), Gaps = 110/483 (22%)
Query: 235 LKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQ 294
+K K ++ + + + Q + ++ L +Q EL+S ++ + K+
Sbjct: 363 IKNKAVVNEDTQGNVSQLQAEVKRLKEQLAELASG-----------QTPPESFLTRDKKK 411
Query: 295 TLDELDKLQQKEEQAERLVKQLEEEAKS------RAEELKLLEEK--------LKGKEAE 340
T + ++A K+ E+E KS + E+L L +EK +K +E +
Sbjct: 412 T-----NYMEYFQEAMLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQ 466
Query: 341 LEKSSAAHTQAT-LLLQEKYDSMVQSL----EDVTAQFESYKALTASEIEDLKLENSSLQ 395
+ + H ++ L E+ D ++ L + + Q E + + +E+ L + +
Sbjct: 467 IIRLEKLHKESRGGFLPEEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRR 526
Query: 396 EKAAKAGKNAEDVQHQILA------TESSNQEYVRMLLDLQTKSALKE----TEIKEITV 445
+ + K A+++ Q +A +E S E + A KE +++
Sbjct: 527 LRLLEPVKRAQEMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKA 586
Query: 446 SFLQKITDLQNQLKQQEEDF-----RKQLE-DEEGRKAEKEN---------TTAELTEEI 490
LQ T+L N KQ+ E+F ++QLE + E + +K N T A +E+
Sbjct: 587 QLLQIQTELNNS-KQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEV 645
Query: 491 NKWRLLYEE----LYNKTKPFQL----------QLDAF--------EVEKQALLNE---- 524
++ ++ E + TK +QL ++ +F + +LNE
Sbjct: 646 SQLNKIHAETLKIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPP 705
Query: 525 ------HGAAQEQLNKIRDSYAKLLG------HQNLKQKIKHVVKLKDENSQLKSEVSKL 572
A E+L +++ + L H+NLK + +HV KL+ ++Q++ S
Sbjct: 706 EMNEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQ-QHVDKLEHHSTQMQELFSSE 764
Query: 573 RCQLAKKKQS--------ETKLQE--ELNKVLGIKHFDPSKAFHHESKENFALKTPLKEG 622
R K+++ E +LQE N L + D H KE ++K
Sbjct: 765 RIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSF 824
Query: 623 NTN 625
TN
Sbjct: 825 KTN 827
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 123 bits (308), Expect = 6e-28
Identities = 139/655 (21%), Positives = 292/655 (44%), Gaps = 85/655 (12%)
Query: 8 LLQERGA----QDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNEL 63
LL E+ A + + +++L + E + RL+ L++ L + +++++ +L+ N
Sbjct: 263 LLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGD 322
Query: 64 LKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVT---QRSLEES- 119
L K E + +L+ L L +L + + + KQ +E +L ++ LEE
Sbjct: 323 LSFKLREFAS--HLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKN 380
Query: 120 ---QGKIAQLEGKLVSIEKEKIDEKSETE----KLLEYIEEISCASDQVEKYKLDIAQLE 172
QGK++QLE L ++ EK E +L +E + + + + + LE
Sbjct: 381 EILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLE 440
Query: 173 ENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEM 232
++ ++L+ + EE LS + DL L + KE+ ++ H L A++
Sbjct: 441 TERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQV 500
Query: 233 QNLKQKFI---------------LEQQEREK-------LQQKELQIDSLLQQEKELSSSL 270
+L + L+QQ +EK LQQ+E L Q ++LSSSL
Sbjct: 501 ASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSL 560
Query: 271 HQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLL 330
QK +E K++ ++ +Q ++ + + + +KQLE K +A +L++L
Sbjct: 561 KQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEIL 620
Query: 331 EEKLKGKEAELEKSSAAHTQA---TLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDL 387
+++L+ + + + TQA L K + + +E TA+ E ++A +++ +L
Sbjct: 621 QQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVE--TARQEQHEA--QAQVAEL 676
Query: 388 KLENSSLQEKAAKAGKNAED---VQHQILA-------TESSNQEYVRMLLDLQTKSALKE 437
+L+ S Q+KA + + A++ +Q Q+ A T+ S +E R D +
Sbjct: 677 ELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCI 736
Query: 438 TEIKEITVSFLQKITDLQNQLKQQE---------------------EDFRKQLEDEEGRK 476
+E+K T S +++ + +L+++ E R++L + +
Sbjct: 737 SELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQ 796
Query: 477 AEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIR 536
E+ +L +E+ WR YE+ + + F+ + L E A+++L + +
Sbjct: 797 HTAESECEQLVKEVAAWRERYEDSQQEEAQYGAM---FQEQLMTLKEECEKARQELQEAK 853
Query: 537 DSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELN 591
+ A + H L+ + + ++E ++L + +++ Q+ +K+ KL ++L+
Sbjct: 854 EKVAGIESHSELQ-----ISRQQNELAELHANLARALQQVQEKEVRAQKLADDLS 903
Score = 99.8 bits (247), Expect = 7e-21
Identities = 154/679 (22%), Positives = 281/679 (41%), Gaps = 95/679 (13%)
Query: 10 QERGAQDRRIQDLETELEKMEA--RLNAALREKTSLSANNATLEKQLIELTRTNELLKSK 67
+ERG Q+R + L E + +A L A R + + NA L +Q +E E L
Sbjct: 997 EERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNA-LNEQRVEFATLQEALAHA 1055
Query: 68 FSENGNQKNLRILSLELMKLRNKRETKMRGMMA-KQEGMEMKLQVTQRSLEESQGKIAQL 126
+E + EL KLR +++ + +Q ++K Q+ ++ E + G AQ
Sbjct: 1056 LTEKEGKDQ------ELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQS 1109
Query: 127 EG---------KLVSIEKEKIDEKSETEKLLEYIEEI--SCASDQVEKYKLDIA--QLEE 173
E KL ++ E + + +K E + + S +++ + + D A L+
Sbjct: 1110 EAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQG 1169
Query: 174 NLKEKNDEI---LSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNA 230
L+EK E+ S S + + +V+D + E E + V R R+ E N+
Sbjct: 1170 QLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKA----EDEWKAQVARGRQEAERKNS 1225
Query: 231 EMQNLKQKF-ILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFE 289
+ +L+++ IL +Q EK + + ++ L+ E E S L ++L Q E
Sbjct: 1226 LISSLEEEVSILNRQVLEK-EGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAA 1284
Query: 290 EELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAE-------ELKLLEEKLKGKEAELE 342
E +E+ L+++ E+ + L +E S+AE ELK +EK KE L
Sbjct: 1285 ERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALS 1344
Query: 343 KSSAAHTQATLLLQEKYDS--MVQSLEDVTAQFE---------SYKALTASEIEDLKLEN 391
HT L+ E + + Q L+ A E S +A E L+ +
Sbjct: 1345 TLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQR 1404
Query: 392 S-----SLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSA------------ 434
L++K A+ + A+ Q+ A ++S E + ML A
Sbjct: 1405 ELGELIPLRQKVAEQERTAQ----QLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANL 1460
Query: 435 ---LKETEIKEITVSFLQKI----TDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELT 487
E E+ + ++Q++ D + +L + + + + + E A+ E ++
Sbjct: 1461 GRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVL 1520
Query: 488 EEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDS-YAKLLGHQ 546
EE R ++E K QL+ F+ E+ +E K+ DS A + Q
Sbjct: 1521 EE----RQRFQEERQKLTAQVEQLEVFQREQTK------QVEELSKKLADSDQASKVQQQ 1570
Query: 547 NLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQS--ETKLQEELNKVLGIKHFDPSKA 604
LK + + E +L++++++L+ QL++K+Q+ KLQ E K H+D K
Sbjct: 1571 KLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKT----HYDAKKQ 1626
Query: 605 FHHESKENFALKTPLKEGN 623
+ E +E L++ N
Sbjct: 1627 QNQELQEQLRSLEQLQKEN 1645
Score = 84.7 bits (208), Expect = 2e-16
Identities = 126/570 (22%), Positives = 235/570 (41%), Gaps = 66/570 (11%)
Query: 28 KMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKL 87
++E L+AAL++K L N L+ +L +L L+ + + +L LE +K
Sbjct: 361 QLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQ 420
Query: 88 R------NKRETKMRGMMAKQEG--MEMKLQVTQRSLEESQGKIAQLEGKL------VSI 133
N + + R M + E E KL + EE + +++ L L +S
Sbjct: 421 EAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQ 480
Query: 134 EKEKIDEKSE------TEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQ 187
KE++++ S+ T ++ E++ + +++ ++A L++ KEK ++ Q
Sbjct: 481 AKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQ 540
Query: 188 SLEENIVILSKQVEDLNVKCQLLEKE-----------KEDHVNRNREHNENLNAEMQN-- 234
E+ L QVE L+ + E++ ++DH + E A ++
Sbjct: 541 QQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERD 600
Query: 235 --LKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEEL 292
LKQ LE+++ KL+ + Q LQ E S + Q E + EE
Sbjct: 601 AALKQLEALEKEKAAKLEILQQQ----LQVANEARDSAQTSVTQAQREKAELSRKVEE-- 654
Query: 293 KQTLDELDKLQQKEEQAE--RLVKQLEEEAKSRAEELKLLEEKLKGKEA-ELEKSSAAHT 349
Q E + +Q E QA+ L QL E + E+ ++ +EK + +E + K S T
Sbjct: 655 LQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVT 714
Query: 350 QATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQ 409
+ +L +E+ +LE+ KA T S +E K E L+E+ +AG+ + +
Sbjct: 715 KGSL--EEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEE--RAGRKGLEAR 770
Query: 410 HQILA------TESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD---------- 453
Q L TE +E + T + E +KE+ ++ ++ D
Sbjct: 771 LQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVA-AWRERYEDSQQEEAQYGA 829
Query: 454 -LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLD 512
Q QL +E+ K ++ + K + + +I++ + EL+ Q+
Sbjct: 830 MFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQ 889
Query: 513 AFEVEKQALLNEHGAAQEQLNKIRDSYAKL 542
EV Q L ++ QE++ A+L
Sbjct: 890 EKEVRAQKLADDLSTLQEKMAATSKEVARL 919
Score = 83.2 bits (204), Expect = 7e-16
Identities = 138/666 (20%), Positives = 273/666 (40%), Gaps = 109/666 (16%)
Query: 9 LQERGAQDRRIQDLETE----LEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL 64
L+ER A ++++ LE E LE ++ +L A + S + +++ EL+R E L
Sbjct: 596 LRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEEL 655
Query: 65 KSKFS---ENGNQKNLRILSLEL-MKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQ 120
++ + ++ ++ LEL ++ ++ T+ + +++ ++ +LQ + SL+ ++
Sbjct: 656 QACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTK 715
Query: 121 GKIAQLEGKLVSIEKEK---IDE-KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLK 176
G + + + + +E+ I E K+ET L +E+ ++E+ + LE L+
Sbjct: 716 GSLEEEKRRAADALEEQQRCISELKAETRSL---VEQHKRERKELEEERAGRKGLEARLQ 772
Query: 177 EKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK-------EDHVNRNREHNENLN 229
+ + + + L + +C+ L KE ED ++
Sbjct: 773 QLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQ 832
Query: 230 AEMQNLKQKFILEQQEREKLQQK--------ELQIDSLLQQEKELSSSLHQKLCSFQEEM 281
++ LK++ +QE ++ ++K ELQI + EL ++L + L QE+
Sbjct: 833 EQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKE 892
Query: 282 VKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA-- 339
V+ + L D+L LQ+K + V +LE + E+ + +L + A
Sbjct: 893 VRAQKL--------ADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARA 944
Query: 340 ---------ELEKSSAAHTQATL-LLQEKYDSMVQSLEDVTA-------QFESYKALTAS 382
E + TQA L ++ + + M LE + A Q + +
Sbjct: 945 GDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQER 1004
Query: 383 EIEDLKLENSSLQ-----EKAAKAG-----KNA------------EDVQHQILATESSNQ 420
E+ L E Q EKAA+A +NA E + H + E +Q
Sbjct: 1005 EVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQ 1064
Query: 421 EYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKE 480
E ++ L+ +IKE L+++ QLK+Q K+ G ++E
Sbjct: 1065 ELAKL-------RGLEAAQIKE-----LEELRQTVKQLKEQLAKKEKEHASGSGAQSEAA 1112
Query: 481 NTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFE---VEKQALLNEHGAAQEQLNKIRD 537
T ++ R +L + + Q Q D+ E ++A E +A E L +
Sbjct: 1113 GRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLE 1172
Query: 538 SYAKLLGHQN------------LKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETK 585
A+ LGH + K++ K +DE K++V++ R + +K +
Sbjct: 1173 EKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDE---WKAQVARGRQEAERKNSLISS 1229
Query: 586 LQEELN 591
L+EE++
Sbjct: 1230 LEEEVS 1235
Score = 62.8 bits (151), Expect = 9e-10
Identities = 68/320 (21%), Positives = 145/320 (45%), Gaps = 20/320 (6%)
Query: 27 EKMEARLNAALREKTS--LSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLEL 84
E + R A +E+T+ L A A+ +QL L + + LL + G + NL LE+
Sbjct: 1408 ELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEV 1467
Query: 85 MKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSET 144
+L RE ++ + A + E +L QR E+Q +LE E K+ E
Sbjct: 1468 -ELDQAREKYVQELAAVRADAETRLAEVQR---EAQSTARELEVMTAKYEGAKVKVLEER 1523
Query: 145 EKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLN 204
++ E ++++ +Q+E ++ + + E L +K + + ++ + + Q +
Sbjct: 1524 QRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQ 1583
Query: 205 VKCQLLE---KEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQ 261
+ Q L+ E + +++ + E+ +M+ K + ++Q+ ++LQ++ ++ L +
Sbjct: 1584 QEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQK 1643
Query: 262 QEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD-KLQQKEEQAERLVKQLEEEA 320
+ KEL + + Q+ +K K E +QT L +++ E Q +QL +
Sbjct: 1644 ENKELRAEAERLGHELQQAGLKTK-----EAEQTCRHLTAQVRSLEAQVAHADQQLRDLG 1698
Query: 321 KSRAEELKLLEEKLKGKEAE 340
K ++ + LK +E +
Sbjct: 1699 K-----FQVATDALKSREPQ 1713
Score = 54.3 bits (129), Expect = 3e-07
Identities = 84/382 (21%), Positives = 162/382 (42%), Gaps = 71/382 (18%)
Query: 8 LLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSK 67
L QE +Q R ++L EL+ + + + ++L + + + + EL L +
Sbjct: 1311 LRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQL 1370
Query: 68 FSENGNQKNLRILSLELMK----------LRNKRET----KMRGMMAKQEGMEMKLQVTQ 113
+E + LE K LR +RE +R +A+QE +L+ +
Sbjct: 1371 QAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEK 1430
Query: 114 RSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQV-EKYKLDIAQLE 172
S E + + G L++ E + E++ + +E DQ EKY ++A +
Sbjct: 1431 ASYAEQLSMLKKAHG-LLAEENRGLGERANLGRQFLEVE-----LDQAREKYVQELAAVR 1484
Query: 173 ENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEM 232
+ + + E+ QS + +++ + E VK +LE+ + R +E + L A++
Sbjct: 1485 ADAETRLAEVQREAQSTARELEVMTAKYEGAKVK--VLEERQ-----RFQEERQKLTAQV 1537
Query: 233 QNLK-------------QKFILEQQEREKLQQKEL------------QIDSLLQQEKELS 267
+ L+ K + + + K+QQ++L + L Q EL
Sbjct: 1538 EQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQ 1597
Query: 268 SSLHQKLCS---FQEEMVKEKNLFE------EELKQTLDELDKLQQKEEQAERLVKQLEE 318
+ L QK + ++ +M K K ++ +EL++ L L++LQ++ K+L
Sbjct: 1598 AQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKEN-------KELRA 1650
Query: 319 EAKSRAEELKLLEEKLKGKEAE 340
EA+ EL+ + LK KEAE
Sbjct: 1651 EAERLGHELQ--QAGLKTKEAE 1670
Score = 44.3 bits (103), Expect = 3e-04
Identities = 80/368 (21%), Positives = 158/368 (42%), Gaps = 43/368 (11%)
Query: 249 LQQKELQIDSLLQQ---EKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQK 305
LQ + Q+ L +Q E+ L +L +++ EK+ ++Q +D L L +K
Sbjct: 209 LQTPQFQMRRLKKQLADERSNRDELELELAE-NRKLLTEKDAQIAMMQQRIDRLALLNEK 267
Query: 306 EEQAERLVKQLEE-EAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 364
+ + K+LEE K+ + ++L E + ++ + EKS + K + + +
Sbjct: 268 QAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQ---------MDRKINQLSE 318
Query: 365 SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR 424
D++ + + AS ++ L+ + L E+ +KA + + Q Q+ S+
Sbjct: 319 ENGDLSFKLREF----ASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSA------ 368
Query: 425 MLLDLQTKSALKE-TEIKEITVSFLQK-ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENT 482
LQ K L+E EI + +S L++ ++ LQ+ Q++ + + E K E
Sbjct: 369 ---ALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATL 425
Query: 483 TAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQAL----------LNEHGAAQEQL 532
A T+ + +L E + + FE EKQ L ++ A+E+L
Sbjct: 426 AANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEEL 485
Query: 533 NKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSE--TKLQEEL 590
+ ++ L Q + + L Q E++ L+ Q AK+KQ++ LQ++
Sbjct: 486 EQASQAHGARLTAQ-VASLTSELTTLNATIQQQDQELAGLK-QQAKEKQAQLAQTLQQQE 543
Query: 591 NKVLGIKH 598
G++H
Sbjct: 544 QASQGLRH 551
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 123 bits (308), Expect = 6e-28
Identities = 121/546 (22%), Positives = 249/546 (45%), Gaps = 50/546 (9%)
Query: 85 MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 142
MKL K + ++ ++E MK + T+ L +++ K +LE K+V++ +EK D +
Sbjct: 834 MKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQL 893
Query: 143 ETEKLLEYIEEISCASDQVEKYKL-------DIAQLEENLKEKNDEILSLKQSLEENIVI 195
+ + + + + DQ+ K K+ ++ + E+ +E N E+ + K+ LE+
Sbjct: 894 QVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 953
Query: 196 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQ 255
L K ++DL + +EKEK H N+ +NL EM L + +E++ LQ+ Q
Sbjct: 954 LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1009
Query: 256 IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 315
LQ E++ ++L + ++++ + E+E K +D L++ + + E +K
Sbjct: 1010 TLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMD----LERAKRKLEGDLKL 1065
Query: 316 LEEEAKSRAEELKLLEEKLKGKEAELE--KSSAAHTQA-TLLLQEKYDSMVQSLEDVTAQ 372
+E + + L EKLK KE E+ + QA + LQ+K + +E++ +
Sbjct: 1066 AQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEE 1125
Query: 373 FESYKALTA---SEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDL 429
E+ +A A + DL E + E+ +AG QI + E+ +M DL
Sbjct: 1126 IEAERASRAKAEKQRSDLSRELEEISERLEEAG---GATSAQIEMNKKREAEFQKMRRDL 1182
Query: 430 QTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEE 489
+ + E + + +L Q+ + +++LE E+ + N A E
Sbjct: 1183 EESTLQHEATAAALRKKHADSVAELGEQIDSLQR-VKQKLEKEKSELKMEINDLASNMET 1241
Query: 490 INKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLL------ 543
++K + +E++ + ++ E E+Q L+NE A + +L+ +++ L
Sbjct: 1242 VSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAM 1301
Query: 544 ------GHQNLKQKIKHVVKLKDENSQLKSEVSK-----------LRCQLAKKKQSETKL 586
G Q Q+I+ + + +E ++ KS ++ LR Q ++++++ +L
Sbjct: 1302 VSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAEL 1361
Query: 587 QEELNK 592
Q ++K
Sbjct: 1362 QRGMSK 1367
Score = 112 bits (279), Expect = 1e-24
Identities = 139/646 (21%), Positives = 285/646 (44%), Gaps = 68/646 (10%)
Query: 1 MTLLIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRT 60
+T R L E + I DLE L K+E +A + +L+ A L++ + +LT+
Sbjct: 940 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKE 999
Query: 61 NELLKSKFSENGNQKNLRILSLELMKLR--NKRETKMRGMMAKQEGMEMKLQVTQRSLEE 118
+ L + +Q+ L L +E K+ K +TK+ + EG + + LE
Sbjct: 1000 KKAL-----QEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLER 1054
Query: 119 SQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIE----EISCASDQVEKYKLDIAQLEEN 174
++ K LEG L ++ +D +++ ++L E ++ E+S ++E + QL++
Sbjct: 1055 AKRK---LEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKK 1111
Query: 175 LKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQN 234
+KE I L++ +E +K + + L +E E+ R E +A+++
Sbjct: 1112 IKELQARIEELEEEIEAERASRAKAEKQRSD----LSRELEEISERLEEAGGATSAQIEM 1167
Query: 235 LKQKFILEQQEREKLQQKELQID----SLLQQEKELSSSLHQKLCSFQ---EEMVKEKNL 287
K++ Q+ R L++ LQ + +L ++ + + L +++ S Q +++ KEK+
Sbjct: 1168 NKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSE 1227
Query: 288 FEEELKQTLDELDKLQQKEEQAERLVKQLEE---EAKSRAEELKLLEEKLKGKEAELEKS 344
+ E+ ++ + + + E++ + LE+ E K++ EE + L +L ++A L
Sbjct: 1228 LKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTE 1287
Query: 345 SAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKN 404
S ++ L EK D+MV L F ++E+ S+L A +
Sbjct: 1288 SGEFSRQ---LDEK-DAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHD 1343
Query: 405 AEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEED 464
+ ++ Q + + E R + ++ A T+ + + +++ + + +L Q+ +D
Sbjct: 1344 CDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQD 1403
Query: 465 FRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEE-------LYNKTKPFQLQL------ 511
+ +E + A E T L E+ + E L K + F L
Sbjct: 1404 AEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQK 1463
Query: 512 -DAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGH--------QNLKQKI---------- 552
+ + E +A E + +L K++++Y + L H +NL+Q+I
Sbjct: 1464 YEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEG 1523
Query: 553 -KHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIK 597
KH+ +L+ QL E S+L+ L +++E L+ E K+L I+
Sbjct: 1524 GKHIHELEKVKKQLDHEKSELQTSL---EEAEASLEHEEGKILRIQ 1566
Score = 101 bits (251), Expect = 2e-21
Identities = 127/622 (20%), Positives = 270/622 (43%), Gaps = 75/622 (12%)
Query: 5 IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRT-NEL 63
I L +E+ A Q +L+ E ++N + KT L LE L + + +L
Sbjct: 993 IAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDL 1052
Query: 64 LKSKFSENGNQKNLRILSLE-------LMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSL 116
++K G+ K + +++ L + K+E +M + K E + Q+ +
Sbjct: 1053 ERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKI 1112
Query: 117 EESQGKIAQLEGKL-------VSIEKEKIDEKSETEKLLEYIEEISCA-SDQVEKYKLDI 168
+E Q +I +LE ++ EK++ D E E++ E +EE A S Q+E K
Sbjct: 1113 KELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKRE 1172
Query: 169 AQ-------LEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKED---HV 218
A+ LEE+ + +L++ +++ L +Q++ L Q LEKEK + +
Sbjct: 1173 AEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEI 1232
Query: 219 NRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSF- 277
N + E ++ N ++ + + +++ KE + L+ + + LH + F
Sbjct: 1233 NDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFS 1292
Query: 278 -----QEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEE 332
++ MV + + ++ Q ++EL + ++E +A+ + + A+ + L+ E
Sbjct: 1293 RQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYE 1352
Query: 333 KLKGKEAELEKSSAAHTQATLLLQEKYDS-MVQSLEDVTAQFESYKALTASEIEDLKLEN 391
+ + +AEL++ + + KY++ +Q E++ E K A ++D +
Sbjct: 1353 EEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEEL----EEAKKKLAQRLQDAEEHV 1408
Query: 392 SSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKI 451
++ K A K + +Q+++ +++D++ +A
Sbjct: 1409 EAVNSKCASLEKTKQRLQNEV----------EDLMIDVERSNAACIA------------- 1445
Query: 452 TDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQL 511
L +++ +F K L + K + E T AEL + R L EL+ ++ L
Sbjct: 1446 ------LDKKQRNFDKVLAE---WKQKYEETQAELEASQKESRSLSTELFKVKNAYEESL 1496
Query: 512 DAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSK 571
D E K+ E+ Q++++ + + A+ H + +K+K +L E S+L++ + +
Sbjct: 1497 DHLETLKR----ENKNLQQEISDLTEQIAEGGKHIHELEKVKK--QLDHEKSELQTSLEE 1550
Query: 572 LRCQLAKKKQSETKLQEELNKV 593
L ++ ++Q ELN+V
Sbjct: 1551 AEASLEHEEGKILRIQLELNQV 1572
Score = 100 bits (250), Expect = 3e-21
Identities = 130/620 (20%), Positives = 280/620 (45%), Gaps = 68/620 (10%)
Query: 22 LETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILS 81
L+ ++++++AR+ E + A+ A EKQ +L+R E + + E G + +I
Sbjct: 1108 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI-- 1165
Query: 82 LELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG-KIAQLEGKLVSIEKEKIDE 140
++ KRE + + M E ++ + T +L + +A+L ++ S+++ K
Sbjct: 1166 ----EMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKL 1221
Query: 141 KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQV 200
+ E +L I +++ + V K K + ++ L+++ EI + ++ + I LS Q
Sbjct: 1222 EKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQK 1281
Query: 201 EDLNVKCQLLEK---EKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREK------LQQ 251
L+ + + EK+ V++ + +++ LK++ LE++ + K LQ
Sbjct: 1282 ARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQ--LEEETKAKSTLAHALQS 1339
Query: 252 KELQIDSLLQQ---EKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD----KLQQ 304
D L +Q E+E + L + + E+ + + +E + Q +EL+ KL Q
Sbjct: 1340 ARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1399
Query: 305 KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 364
+ + AE V+ + + S + + L+ +++ ++E+S+A A + L +K +
Sbjct: 1400 RLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNA----ACIALDKKQ----R 1451
Query: 365 SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR 424
+ + V A+++ T +E+E + E+ SL + K E+ + + N+ +
Sbjct: 1452 NFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQ 1511
Query: 425 MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGR--------- 475
+ DL + A I E+ +++ +++L+ E+ LE EEG+
Sbjct: 1512 EISDLTEQIAEGGKHIHELE-KVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELN 1570
Query: 476 --KAEKENTTAELTEEINKWR---LLYEELYNKTKPFQLQL--DAFEVEK--QALLNE-- 524
K+E + AE EE+++ + L E T +++ DA ++K + LNE
Sbjct: 1571 QVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEME 1630
Query: 525 ------HGAAQEQLNKIRDSYAKLLGHQ-NLKQKIKHVVKLKDENSQ-------LKSEVS 570
+ A E L +R++ L Q +L I+ LK++ + +++EV
Sbjct: 1631 IQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVE 1690
Query: 571 KLRCQLAKKKQSETKLQEEL 590
+LR L + ++ ++EL
Sbjct: 1691 ELRASLERTERGRKMAEQEL 1710
Score = 83.6 bits (205), Expect = 5e-16
Identities = 140/618 (22%), Positives = 261/618 (42%), Gaps = 123/618 (19%)
Query: 17 RRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL------------ 64
+R+QD E +E + ++ A EKT N +E +I++ R+N
Sbjct: 1399 QRLQDAEEHVEAVNSK--CASLEKTKQRLQNE-VEDLMIDVERSNAACIALDKKQRNFDK 1455
Query: 65 -----KSKFSEN-----GNQKNLRILSLELMKLRNKRETKMRGMMA-KQEGMEMKLQVTQ 113
K K+ E +QK R LS EL K++N E + + K+E ++ +++
Sbjct: 1456 VLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISD 1515
Query: 114 RSLEESQG--KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQL 171
+ + ++G I +LE ++K+ EKSE + LE E AS + E+ K+ QL
Sbjct: 1516 LTEQIAEGGKHIHELE----KVKKQLDHEKSELQTSLEEAE----ASLEHEEGKILRIQL 1567
Query: 172 EENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAE 231
E N +K ++ I ++++ L K +H+ L+AE
Sbjct: 1568 ELN---------QVKSEIDRKIAEKDEELDQL----------KRNHLRVVESMQSTLDAE 1608
Query: 232 MQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEE 291
+++ ++++ L + E+Q++ +Q E +L + ++K+ L
Sbjct: 1609 IRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNT-----QGILKDTQL---H 1660
Query: 292 LKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAEL----EKSSAA 347
L + D L+++ ER ++ E + L+ E K E EL E+
Sbjct: 1661 LDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLL 1720
Query: 348 HTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAED 407
HTQ T L+ K + LE +Q + E+ED+ E + +EKA KA +A
Sbjct: 1721 HTQNTSLINTK-----KKLETDISQIQG-------EMEDIVQEARNAEEKAKKAITDAAM 1768
Query: 408 VQHQILATESSNQEYVRM-------------LLDLQTKSALK--ETEIKEITVSFLQKIT 452
+ ++ + ++ RM LD + ALK + +I+++ + +
Sbjct: 1769 MAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELES 1828
Query: 453 DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLD 512
+++++ K E K L E R E T E + I + + L ++L K K ++ Q
Sbjct: 1829 EVESEQKHNVEAV-KGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQ-- 1885
Query: 513 AFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL-KSEVSK 571
A E E+Q+ +N L K R K++H ++ E + + +S+V+K
Sbjct: 1886 AEEAEEQSNVN--------LAKFR--------------KLQHELEEAKERADIAESQVNK 1923
Query: 572 LRCQLAKKKQSETKLQEE 589
LR K ++ TK+ E
Sbjct: 1924 LR---VKSREVHTKVISE 1938
Score = 61.2 bits (147), Expect = 3e-09
Identities = 78/375 (20%), Positives = 168/375 (44%), Gaps = 47/375 (12%)
Query: 8 LLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSK 67
L Q + DR+I + + EL++++ LR S+ + TL+ E+ N+ L+ K
Sbjct: 1569 LNQVKSEIDRKIAEKDEELDQLKRN---HLRVVESMQS---TLDA---EIRSRNDALRIK 1619
Query: 68 FSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLE 127
G+ + I + N++ + + +G+ L+ TQ L+++ L+
Sbjct: 1620 KKMEGDLNEMEIQ----LNHANRQAAEALRNLRNTQGI---LKDTQLHLDDAIRGQDDLK 1672
Query: 128 GKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQ 187
+L +E+ ++E E+L +E E+ LD ++ + L +N +++ K+
Sbjct: 1673 EQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKK 1732
Query: 188 SLEENIVILSKQVEDLNVKCQLLEKEKE----------DHVNRNREHNENLNAEMQNLKQ 237
LE +I + ++ED+ + + E++ + + + + ++ + +L +N++Q
Sbjct: 1733 KLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ 1792
Query: 238 -----KFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQ---------KLCSFQEEMVK 283
+ L++ E+ L+ + QI L + +EL S + K E VK
Sbjct: 1793 TVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVK 1852
Query: 284 EKNLFEEELKQTL----DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA 339
E EE ++ + D +DKLQ K + +R ++ EE++ + + L+ +L E
Sbjct: 1853 ELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHEL---EE 1909
Query: 340 ELEKSSAAHTQATLL 354
E++ A +Q L
Sbjct: 1910 AKERADIAESQVNKL 1924
Score = 56.2 bits (134), Expect = 9e-08
Identities = 72/336 (21%), Positives = 147/336 (43%), Gaps = 42/336 (12%)
Query: 22 LETELEKMEARLNAALREKTSLSANNATLEK-------QLIELTRTNELLKSKFSENGNQ 74
+E +L +ME +LN A R+ N + L + R + LK + + +
Sbjct: 1622 MEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERR 1681
Query: 75 KNLRILSLELMKLRNKRETKMRGM-MAKQEGMEMKLQV------------TQRSLEESQG 121
NL + E+ +LR E RG MA+QE ++ +V T++ LE
Sbjct: 1682 ANL--MQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETD-- 1737
Query: 122 KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDE 181
I+Q++G++ I +E ++ EK + I + + +++++K + A LE K
Sbjct: 1738 -ISQIQGEMEDIVQEA---RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1793
Query: 182 ILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHN----ENLNAEMQNLKQ 237
+ L+ L+E + K + K + +E E V ++HN + L + +K+
Sbjct: 1794 VKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKE 1853
Query: 238 KFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLD 297
+++R+ + + + +D L + K EE ++ N+ + ++
Sbjct: 1854 LTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQ--------AEEAEEQSNVNLAKFRKLQH 1905
Query: 298 ELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 333
EL++ +++ + AE V +L KSR K++ E+
Sbjct: 1906 ELEEAKERADIAESQVNKL--RVKSREVHTKVISEE 1939
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 122 bits (305), Expect = 1e-27
Identities = 134/550 (24%), Positives = 258/550 (46%), Gaps = 58/550 (10%)
Query: 85 MKLRNKRETKMRGMMAKQEGMEMKLQV--TQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 142
MKL K + ++ ++E MK + + +LE+S+ + +LE K+VS+ +EK D +
Sbjct: 832 MKLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQL 891
Query: 143 ETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND----------EILSLKQSLEEN 192
+ + + + + DQ+ K K+ QLE +KE N+ E+ + K+ LE+
Sbjct: 892 QVQAEQDNLNDAEERCDQLIKNKI---QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE 948
Query: 193 IVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK 252
L K ++DL + +EKEK H N+ +NL EM L + +E++ LQ+
Sbjct: 949 CSELKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDEIIAKLTKEKKALQEA 1004
Query: 253 ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 312
Q LQ E++ +SL + ++++ + E+E K +D L++ + + E
Sbjct: 1005 HQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMD----LERAKRKLEGD 1060
Query: 313 VKQLEEEAKSRAEELKLLEEKLKGKEAEL-EKSSAAHTQATLLLQ-----EKYDSMVQSL 366
+K +E + LEEKLK KE ++ +++S + L LQ ++ + ++ L
Sbjct: 1061 LKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEEL 1120
Query: 367 EDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRML 426
E+ + +A DL E + E+ +AG A V QI + E+ +M
Sbjct: 1121 EEELEAERTARAKVEKLRSDLSRELEEISERLEEAG-GATSV--QIEMNKKREAEFQKMR 1177
Query: 427 LDLQ--------TKSALKETEIKEITVSFLQKITDLQ---NQLKQQEEDFRKQLEDEEGR 475
DL+ T +AL++ + ++I +LQ +L++++ +F+ +L+D
Sbjct: 1178 RDLEEATLQHEATAAALRKKHADSV-AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSN 1236
Query: 476 -------KAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQAL---LNEH 525
KA E + L ++ N++R+ EE F Q + E L L E
Sbjct: 1237 MEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEK 1296
Query: 526 GAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKK-QSET 584
A QL + + SY + + ++LK++++ K K+ + + ++ C L +++ + ET
Sbjct: 1297 EALISQLTRGKLSYTQQM--EDLKRQLEEEGKAKNALAH-ALQSARHDCDLLREQYEEET 1353
Query: 585 KLQEELNKVL 594
+ + EL +VL
Sbjct: 1354 EAKAELQRVL 1363
Score = 105 bits (262), Expect = 1e-22
Identities = 149/644 (23%), Positives = 273/644 (42%), Gaps = 71/644 (11%)
Query: 4 LIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN-E 62
+I L +E+ A Q +L+ E ++N+ + K L LE L + + +
Sbjct: 990 IIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMD 1049
Query: 63 LLKSKFSENGNQKNLR--ILSLELMKLR-----NKRETKMRGMMAKQEGMEMKLQVTQRS 115
L ++K G+ K + I+ LE KL+ K+E + +K E ++ Q+
Sbjct: 1050 LERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKK 1109
Query: 116 LEESQGKIAQLEGKL-------VSIEKEKIDEKSETEKLLEYIEEISCASD-QVEKYKLD 167
L+E+Q +I +LE +L +EK + D E E++ E +EE A+ Q+E K
Sbjct: 1110 LKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR 1169
Query: 168 IAQLEENLKEKNDEIL-------SLKQSLEENIVILSKQVEDLNVKCQLLEKEKE----- 215
A+ ++ ++ + L +L++ +++ L +Q+++L Q LEKEK
Sbjct: 1170 EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE 1229
Query: 216 -DHVNRNREHNENLNAEMQNLKQKFILEQQ--------------------EREKLQQKEL 254
D V N E A ++ + + LE Q +R KLQ +
Sbjct: 1230 LDDVTSNMEQIIKAKANLEKVSRT--LEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENG 1287
Query: 255 QIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVK 314
++ L++++ L S L + S+ ++M K EEE K LQ + L +
Sbjct: 1288 ELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLRE 1347
Query: 315 QLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFE 374
Q EEE +++AE ++L + K Q T L+E + Q L+D E
Sbjct: 1348 QYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVE 1407
Query: 375 SYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSA 434
+ A +S L+ LQ + + E A + + + ++L + + K
Sbjct: 1408 AVNAKCSS----LEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYE 1463
Query: 435 LKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAE---LTEEIN 491
++E++ S ++ L +L + + + + LE E K E +N E LTE++
Sbjct: 1464 ESQSELE----SSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG 1519
Query: 492 KWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE-QLNKIRDSYAKLLGHQNLKQ 550
+ EL K QL+ ++E Q+ L E A+ E + KI + L +K
Sbjct: 1520 EGGKNVHELEKVRK----QLEVEKLELQSALEEAEASLEHEEGKILRAQ---LEFNQIKA 1572
Query: 551 KIKHVVKLKDEN-SQLKSEVSKLRCQLAKKKQSETKLQEELNKV 593
+I+ + KDE Q K ++ L +ET+ + E+ +V
Sbjct: 1573 EIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRV 1616
Score = 104 bits (260), Expect = 2e-22
Identities = 129/648 (19%), Positives = 280/648 (43%), Gaps = 78/648 (12%)
Query: 1 MTLLIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRT 60
+T R L E + I DLE L K+E +A + +L+ A L++ + +LT+
Sbjct: 938 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE 997
Query: 61 NELLKSKFSENGNQKNLRILSLELMKLRNKRETKMR---------GMMAKQEGMEMKLQV 111
+ L + +Q+ L L +E K+ + ++K++ G + +++ + M L+
Sbjct: 998 KKAL-----QEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLER 1052
Query: 112 TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQL 171
+R LE G + + ++ +E +K+ + EKL + +I+ + ++E ++ QL
Sbjct: 1053 AKRKLE---GDLKLTQESIMDLENDKLQLE---EKLKKKEFDINQQNSKIEDEQVLALQL 1106
Query: 172 EENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAE 231
++ LKE I L++ LE +K VE L L +E E+ R E + +
Sbjct: 1107 QKKLKENQARIEELEEELEAERTARAK-VEKLRSD---LSRELEEISERLEEAGGATSVQ 1162
Query: 232 MQNLKQKFILEQQEREKLQQKELQID----SLLQQEKELSSSLHQKLCSFQ---EEMVKE 284
++ K++ Q+ R L++ LQ + +L ++ + + L +++ + Q +++ KE
Sbjct: 1163 IEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1222
Query: 285 KNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKS 344
K+ F+ EL ++++ + + E++ + LE++A +L+ + L + K
Sbjct: 1223 KSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKL 1282
Query: 345 SAAHTQATLLLQEKYD----------SMVQSLEDVTAQFE---SYKALTASEIEDLKLEN 391
+ + L+EK S Q +ED+ Q E K A ++ + +
Sbjct: 1283 QTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDC 1342
Query: 392 SSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKI 451
L+E+ + + ++Q + +N E + +T + + E++E Q++
Sbjct: 1343 DLLREQYEEETEAKAELQRVL---SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1399
Query: 452 TDLQ-----------------NQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWR 494
D + ++L+ + ED +E A + + + +W+
Sbjct: 1400 QDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWK 1459
Query: 495 LLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKH 554
YEE ++ + Q + + E L N + + E L + ++NL+++I
Sbjct: 1460 QKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE------NKNLQEEISD 1513
Query: 555 VVKLKDENSQLKSEVSKLRCQLAKKK--------QSETKLQEELNKVL 594
+ + E + E+ K+R QL +K ++E L+ E K+L
Sbjct: 1514 LTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKIL 1561
Score = 98.6 bits (244), Expect = 2e-20
Identities = 135/612 (22%), Positives = 282/612 (46%), Gaps = 65/612 (10%)
Query: 21 DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN--------------ELLKS 66
+L +LE+ EA ++ R K S + L++QL E + +LL+
Sbjct: 1288 ELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLRE 1347
Query: 67 KFSENGNQKN--LRILSL---ELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG 121
++ E K R+LS E+ + R K ET + +E E K ++ QR L++++
Sbjct: 1348 QYEEETEAKAELQRVLSKANSEVAQWRTKYETD--AIQRTEELEEAKKKLAQR-LQDAEE 1404
Query: 122 KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDE 181
+ + K S+EK K ++E E L+ +E + A+ ++K + + ++ K+K +E
Sbjct: 1405 AVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEE 1464
Query: 182 ILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQ---- 237
S +S ++ LS ++ K + +E +H+ + N+NL E+ +L +
Sbjct: 1465 SQSELESSQKEARSLSTEL----FKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGE 1520
Query: 238 --KFILEQQE-REKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQ 294
K + E ++ R++L+ ++L++ S L++ + K+ Q E + K E +L +
Sbjct: 1521 GGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAE 1580
Query: 295 TLDELDKLQQKEEQ-AERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATL 353
+E+++ ++ ++ + L L+ E +SR E L+ +++K++G E+E + +
Sbjct: 1581 KDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLR-VKKKMEGDLNEMEIQLSHANRMAA 1639
Query: 354 LLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQIL 413
Q++ S+ L+D Q + A+ A+ +DLK + ++ + E+++ +
Sbjct: 1640 EAQKQVKSLQSLLKDTQIQLDD--AVRAN--DDLKENIAIVERRNNLLQAELEELRAVVE 1695
Query: 414 ATESS----NQEYVR-----MLLDLQTKSALKETEIKEITVSFLQ-KITDLQNQLKQQEE 463
TE S QE + LL Q S + + + E ++ LQ ++ + + + EE
Sbjct: 1696 QTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEE 1755
Query: 464 DFRKQLEDEE--GRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQAL 521
+K + D + +KE T+ E + K + K Q +LD E E+ AL
Sbjct: 1756 KAKKAITDAAMMAEELKKEQDTSAHLERMKK------NMEQTIKDLQHRLD--EAEQIAL 1807
Query: 522 LNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQ 581
++QL K+ +L G +QK ++ +K + + +L Q + K+
Sbjct: 1808 ----KGGKKQLQKLEARVRELEGELEAEQK-RNAESVKGMRKS-ERRIKELTYQTEEDKK 1861
Query: 582 SETKLQEELNKV 593
+ +LQ+ ++K+
Sbjct: 1862 NLLRLQDLVDKL 1873
Score = 65.9 bits (159), Expect = 1e-10
Identities = 75/384 (19%), Positives = 171/384 (44%), Gaps = 49/384 (12%)
Query: 15 QDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRT---------NELLK 65
++ +I + E +++A + L EK +++++ +T NE+L+
Sbjct: 1556 EEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLR 1615
Query: 66 SKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQ-EGMEMKLQVTQRSLEESQGKIA 124
K G+ L M+++ +M KQ + ++ L+ TQ L+++
Sbjct: 1616 VKKKMEGD--------LNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAND 1667
Query: 125 QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 184
L+ + +E+ ++E E+L +E+ + E+ ++ ++ + L +N +++
Sbjct: 1668 DLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLIN 1727
Query: 185 LKQSLEENIVILSKQVEDLNVKCQLLEKEKE----------DHVNRNREHNENLNAEMQN 234
K+ +E ++ L +VE+ +C+ E++ + + + + ++ + +L +N
Sbjct: 1728 QKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1787
Query: 235 LKQ-----KFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQ---------KLCSFQEE 280
++Q + L++ E+ L+ + Q+ L + +EL L K E
Sbjct: 1788 MEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSER 1847
Query: 281 MVKEKNLFEEELKQTL----DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKG 336
+KE EE K+ L D +DKLQ K + +R ++ EE+A + + + ++ +L
Sbjct: 1848 RIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHEL-- 1905
Query: 337 KEAELEKSSAAHTQATLLLQEKYD 360
EAE E++ A +Q L + D
Sbjct: 1906 DEAE-ERADIAESQVNKLRAKSRD 1928
Score = 59.7 bits (143), Expect = 8e-09
Identities = 82/374 (21%), Positives = 153/374 (40%), Gaps = 55/374 (14%)
Query: 10 QERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFS 69
Q + R + L+T L+ N LR K + + L + I+L+ N +
Sbjct: 1587 QAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGD---LNEMEIQLSHANRMAAEA-- 1641
Query: 70 ENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGM---EMKLQVTQRSLEESQGKIAQL 126
QK ++ L L + + + +R +E + E + + Q LEE + + Q
Sbjct: 1642 ----QKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQT 1697
Query: 127 EGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLK 186
E E+E I E SE +LL + + +Q +K + D+ QL+ ++E E + +
Sbjct: 1698 ERSRKLAEQELI-ETSERVQLLH--SQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAE 1754
Query: 187 QSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQER 246
+ ++ I + E+L E++ H+ R +++ E ++Q+ L++ E+
Sbjct: 1755 EKAKKAITDAAMMAEELKK-----EQDTSAHLERMKKNMEQTIKDLQHR-----LDEAEQ 1804
Query: 247 EKLQQKELQIDSLLQQEKELSSSLHQ---------KLCSFQEEMVKEKNLFEEELKQTL- 296
L+ + Q+ L + +EL L K E +KE EE K+ L
Sbjct: 1805 IALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLL 1864
Query: 297 ---DELDKLQQKEEQAERLVKQLEE-----------------EAKSRAEELKLLEEKLKG 336
D +DKLQ K + +R ++ EE EA+ RA+ + KL+
Sbjct: 1865 RLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRA 1924
Query: 337 KEAELEKSSAAHTQ 350
K ++ H +
Sbjct: 1925 KSRDIGAKQKMHDE 1938
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 121 bits (304), Expect = 2e-27
Identities = 150/646 (23%), Positives = 286/646 (44%), Gaps = 63/646 (9%)
Query: 5 IRVLLQERGAQDRRIQDLETELEK-MEARLNAALREKTSLSANNATLEKQL---IELTRT 60
+R L QE RI +LE+ LEK ++ N + L A K++ +E +T
Sbjct: 555 LRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKT 614
Query: 61 N-ELLKSKFSENGNQKNLRILS----LELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRS 115
E LK + +K L++L E+ KLR K E + ++ +E + Q
Sbjct: 615 ELESLKHQQDALWTEK-LQVLKQQYQTEMEKLREKCEQEKETLLKDKE------IIFQAH 667
Query: 116 LEESQGK-IAQLEGKLVSIEK--EKIDEKSETEKLLEYIEEISCASDQVEKYKLDI-AQL 171
+EE K + +L+ K +E ++ E + LE EE+S DQ +K K ++ A++
Sbjct: 668 IEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLE--EELSVLKDQTDKMKQELEAKM 725
Query: 172 EENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAE 231
+E ++ S+ + E +I K ++D + +LL KE++ H+ ++ H ENL A+
Sbjct: 726 DEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEAD 785
Query: 232 MQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEE 291
++ + + + + Q + + +E + L QKL + E + E
Sbjct: 786 IKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEV 845
Query: 292 LKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQA 351
Q D +L + Q + L++QLE++ +++K L + E++LE + Q
Sbjct: 846 EAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVY---ESKLEDGNKEQEQT 902
Query: 352 TLLLQEKYDSMVQSLE-----------DVTAQFESYKALTASEIEDLKLENSSLQEKAAK 400
+L EK + ++Q E ++A+ +S L K + +++ K
Sbjct: 903 KQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQK 962
Query: 401 AGKNAEDVQHQILATESS-NQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLK 459
A + E ++ ++L E+ +E L+L K ++ E+ + I+D ++L+
Sbjct: 963 AKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLE 1022
Query: 460 QQEED--------FRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQL 511
+++ R++L D +K N AE +EI++ +L +E + + ++
Sbjct: 1023 TNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQL--QEKEQEVAELKQKI 1080
Query: 512 DAFEVEKQAL------LNEHGAAQE-QLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQ 564
F EK+ + L E G Q+ LN+++ + LKQK HV L + ++
Sbjct: 1081 LLFGCEKEEMNKEITWLKEEGVKQDTTLNELQ---------EQLKQKSAHVNSLAQDETK 1131
Query: 565 LKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESK 610
LK+ + KL L K + T LQE+L ++ + D K SK
Sbjct: 1132 LKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
Score = 107 bits (267), Expect = 3e-23
Identities = 153/663 (23%), Positives = 290/663 (43%), Gaps = 102/663 (15%)
Query: 18 RIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNL 77
++++ E +++ M+A + + + EK +L ++ E LK + SEN N
Sbjct: 1298 QLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENIN---- 1353
Query: 78 RILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLE-ESQGKIAQLEGKLVSIEKE 136
++ LMK K + K E + Q+T +++ ++ +++ E + S+ K+
Sbjct: 1354 ---AVTLMKEELKEK--------KVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQ 1402
Query: 137 KIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVIL 196
+EK E LL+ ++++S D + K K+ + ++ K E K+ +
Sbjct: 1403 YDEEKCE---LLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSE---WKKKAQSRFTQH 1456
Query: 197 SKQVEDLNVKCQLLEKE---KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKE 253
V++L ++ +L KE K++ +N +E + N LK + + ++ K+++KE
Sbjct: 1457 QNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEM---EDDKSKMEKKE 1513
Query: 254 LQIDSLLQQEK----ELSSSLHQKLCSFQE--EMVK----EKNLFEEELKQTLDELDKLQ 303
+++ L+ + EL + QK + E++K +K++ +EL Q L +L
Sbjct: 1514 SNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELG 1573
Query: 304 QKEE----QAERLVKQLEEEAKSRAEEL--------------KLLEEKLKGKEAELEKSS 345
++++ +AE + LE + S EL K EE+LK E LE S
Sbjct: 1574 EEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESES 1633
Query: 346 AAHTQATLLLQEKYDSMV--QSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGK 403
AA E+ + + Q L + + E YK T S + +L N+ LQE+ +
Sbjct: 1634 AAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSEL---NTKLQERE----R 1686
Query: 404 NAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKE------ITVSFLQKITDLQNQ 457
++ ++ + ESS E +++ K+ TE +E + ++ +KI+ LQ
Sbjct: 1687 EVHILEEKLKSVESSQSE--TLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRN 1744
Query: 458 LKQQEEDFRKQLEDEE--------------GRKAEKENTTAELTEEINKWRLLYEELYNK 503
L ++E+ ++ +++E R + E+ A+ E+ + L EEL K
Sbjct: 1745 LTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEK 1804
Query: 504 TKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKL----LGHQNLKQKIKH----V 555
K + L + A VEK+ N A Q N D L L Q L+QKIK +
Sbjct: 1805 NKKYSL-IVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCL 1863
Query: 556 VKLKD----ENSQLKSEVSKLRC-QLAKKKQSETKLQEELNKVLGIKHF-DPSKAFHHES 609
V+ K+ E +L S+ KL+ Q + T+L EE + H P + E+
Sbjct: 1864 VRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEA 1923
Query: 610 KEN 612
+ N
Sbjct: 1924 QHN 1926
Score = 97.1 bits (240), Expect = 5e-20
Identities = 151/675 (22%), Positives = 277/675 (41%), Gaps = 99/675 (14%)
Query: 7 VLLQERGAQDRRIQDLETELEKMEARLNAALRE-KTSLSANNATLEKQLIELTRTNELLK 65
++LQ R Q + I+ L +L E ++ E +T +EK + E LK
Sbjct: 912 MILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLK 971
Query: 66 SKF--SENGNQKNLRILSLELMKLRNKRETKMRGM-MAKQEGME---MKLQVTQRSLEES 119
K E +K L +LEL + + KM M A G+ +L+ Q+ ES
Sbjct: 972 KKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIES 1031
Query: 120 QGKIAQLE-GKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENL--- 175
++ + E ++SI ++K+++++E L+ I EI Q+++ + ++A+L++ +
Sbjct: 1032 LTEVHRRELNDVISIWEKKLNQQAEE---LQEIHEI-----QLQEKEQEVAELKQKILLF 1083
Query: 176 ----KEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAE 231
+E N EI LK+ + L++ E L K+K HVN + L A
Sbjct: 1084 GCEKEEMNKEITWLKEEGVKQDTTLNELQEQL--------KQKSAHVNSLAQDETKLKAH 1135
Query: 232 MQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEE 291
++ L+ +E LQ++ +++ L +++K S L KL + EE K+ E+
Sbjct: 1136 LEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKS 1195
Query: 292 LKQTLDE-LDKLQQKEEQAERL---VKQLEEEAKSRAEELKLLEEK-------------- 333
K D+ L+ + EE A +L K+ E +++ EL +
Sbjct: 1196 NKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQH 1255
Query: 334 --LKGKEA---------ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTAS 382
K KEA ELE T+ L + LE+ Q +S KA
Sbjct: 1256 RTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKA---- 1311
Query: 383 EIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKE 442
+IE L E +LQ++ + A + + I + E + + ++ + K+ EI
Sbjct: 1312 DIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISS 1371
Query: 443 ITVSFLQKITDLQNQLKQQEED-----FRKQLEDEEGRKAE-------------KENTTA 484
++ LQN + E++ RKQ ++E+ + KE +A
Sbjct: 1372 LSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISA 1431
Query: 485 ELTEEINKWRLLYEEL-----------YNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLN 533
E+++ W + E N K Q+QL+ E + +E+L+
Sbjct: 1432 --LEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELD 1489
Query: 534 KIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKV 593
+ + L G K K K + ++LKS+ +++ +L +T E LN+V
Sbjct: 1490 QQNKRFDCLKGEME-DDKSKMEKKESNLETELKSQTARI-MELEDHITQKTIEIESLNEV 1547
Query: 594 LGIKHFDPSKAFHHE 608
L K+++ K H+
Sbjct: 1548 L--KNYNQQKDIEHK 1560
Score = 89.4 bits (220), Expect = 9e-18
Identities = 135/637 (21%), Positives = 281/637 (44%), Gaps = 100/637 (15%)
Query: 39 EKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNL----RILSLELMKLRN----K 90
E L N+ +L K+ + + R + +S S G L ++L E KL+
Sbjct: 123 EAEDLVGNSDSLNKEQL-IQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQS 181
Query: 91 RETKMRGMMAKQEGMEMKLQVTQR-------SLEESQGKIAQLEGKLVSIEKEKIDEKSE 143
++ +R + +E ++M Q + SLEE I+ L+ + VS+ K+++
Sbjct: 182 QDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQ-VSLLKQRLRNGPM 240
Query: 144 TEKLLEYIEEISCASDQVEKYKLDIAQ----LEENLKEKNDEILSLKQSLEENIVILSKQ 199
+L+ + ++ ++ K + + +E+ K E L + +EN++ K+
Sbjct: 241 NVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKE 300
Query: 200 -VEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDS 258
++ +C LL EKE E L+ +Q L++ L E+ KL + +
Sbjct: 301 TIQSHKEQCTLLTSEKE-------ALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKN 353
Query: 259 LLQQEK--------ELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAE 310
L++Q + E +H+ L +EE+ + ++ +KQ + ++L++++E++E
Sbjct: 354 LIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRS----RIKQMTTQGEELREQKEKSE 409
Query: 311 RLVKQLEEEAKSRAEELKLLEEKLKGKEAE----LEKSSAAHTQATLLLQEKYDSMVQSL 366
R + E+A S A++ + KLK + E +EK+S + + LQ++ + Q +
Sbjct: 410 RAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSE---EERISLQQELSRVKQEV 466
Query: 367 EDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI-LATESSNQEYVRM 425
DV + + ++ + +L QE K + Q Q+ +A E S EY+++
Sbjct: 467 VDVMKKSSEEQIAKLQKLHEKELARKE-QELTKKLQTREREFQEQMKVALEKSQSEYLKI 525
Query: 426 L-------------LDLQTKSALKETE-----IKEITVSFLQKITDLQNQLKQQEEDFRK 467
L+LQ K+ L E+E +++ ++ +I +L++ L++ ++ +
Sbjct: 526 SQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKN 585
Query: 468 QLED-EEGRKAEKENTTAELTEEINKWRLLYEELYNK-----TKPFQLQLDAFEVEKQAL 521
Q +D +AEK E+T + K + E L ++ T+ Q+ ++ E + L
Sbjct: 586 QSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKL 645
Query: 522 LNEHGAAQEQLNK---------IRDSYAKLLGHQNLKQ--------------KIKHVVKL 558
+ +E L K I + K L ++KQ K +H KL
Sbjct: 646 REKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARH--KL 703
Query: 559 KDENSQLKSEVSKLRCQL-AKKKQSETKLQEELNKVL 594
++E S LK + K++ +L AK + + Q++++ ++
Sbjct: 704 EEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSII 740
Score = 74.7 bits (182), Expect = 2e-13
Identities = 112/516 (21%), Positives = 214/516 (41%), Gaps = 96/516 (18%)
Query: 16 DRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQK 75
+ +I L+ L + E L +EK +++ + Q E R +L ++ ++ +Q
Sbjct: 1735 EEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQE--RLIKLEHAEAKQHEDQS 1792
Query: 76 NLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQV----------TQRSLEESQGKIAQ 125
+ L EL + +NK+ + + ++EG + +Q Q++L+E +
Sbjct: 1793 MIGHLQEELEE-KNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQI 1851
Query: 126 LEGKLVSIE----KEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDE 181
LE K+ ++ ++K + E E+L E++ A Q++ LEEN +EK+
Sbjct: 1852 LEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQ-ALQQMDGRNKPTELLEENTEEKSKS 1910
Query: 182 ILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE-----------DHVNRNREHNENLNA 230
L + L + Q DL K E+EK+ D +EH +
Sbjct: 1911 HLVQPKLLSN----MEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQ---- 1962
Query: 231 EMQNLKQKFILEQQEREKLQQKELQID--------------SLLQQEKELSSSLHQKLCS 276
E++ LK+++ E++E+ K +Q++L++ L Q+E+EL ++ + +
Sbjct: 1963 ELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINK 2022
Query: 277 FQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKG 336
QE E L E ++T L K+ +K++ +R K+ EE +R EE + K++
Sbjct: 2023 AQEV---EAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEE---MTAKVRD 2076
Query: 337 KEAELEKSSAAHTQATLLLQEKYDSMVQSLED------VTAQFESYKALTASEIEDLKLE 390
+ +LE+ LQ+KY ++ E+ + ++ A + I D KL+
Sbjct: 2077 LQTQLEE-----------LQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLK 2125
Query: 391 NSSLQEKAAKAGKNAEDVQHQILAT--------------------ESSNQEYVRMLLDLQ 430
+E+ + + + AT E + EY+R +L
Sbjct: 2126 EQEFREQIHNLEDRLKKYEKNVYATTVGTPYKGGNLYHTDVSLFGEPTEFEYLRKVLFEY 2185
Query: 431 TKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFR 466
+T K IT + K D Q Q + ED R
Sbjct: 2186 MMGRETKTMAKVITT--VLKFPDDQTQKILEREDAR 2219
Score = 56.2 bits (134), Expect = 9e-08
Identities = 64/276 (23%), Positives = 129/276 (46%), Gaps = 43/276 (15%)
Query: 15 QDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQ 74
Q + + ++E + +E +L A REK L K+++ L + +L+ + +Q
Sbjct: 1914 QPKLLSNMEAQHNDLEFKLAGAEREKQKLG-------KEIVRLQKDLRMLRKE-----HQ 1961
Query: 75 KNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSL-EESQGKIAQLEGKLVSI 133
+ L IL E +RE K++ +QE +E+K T + L E ++AQ E +L
Sbjct: 1962 QELEILKKE---YDQEREEKIK---QEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMT 2015
Query: 134 EKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENI 193
KE I++ E E ++ +E ++ + QL + + EK+D++ + EE
Sbjct: 2016 IKETINKAQEVE------------AELLESHQEETNQLLKKIAEKDDDLKRTAKRYEE-- 2061
Query: 194 VILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKE 253
IL + E++ K + L+ + E+ +++ + L E +N + + + +L QK
Sbjct: 2062 -ILDAREEEMTAKVRDLQTQLEE---LQKKYQQKLEQE-ENPGNDNVTIMELQTQLAQKT 2116
Query: 254 LQIDSLLQQEKELSSSLHQKLCSFQEEMVK-EKNLF 288
I +E+E +H + ++ + K EKN++
Sbjct: 2117 TLISDSKLKEQEFREQIH----NLEDRLKKYEKNVY 2148
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 120 bits (301), Expect = 4e-27
Identities = 158/695 (22%), Positives = 309/695 (44%), Gaps = 94/695 (13%)
Query: 4 LIRVLLQERGAQDRRIQDLETELEKMEARL----NAALREKTSLSANNATLEKQLIELTR 59
L+R QE+ + ++++++E E +++ L NA EKT L N ++ + + T
Sbjct: 832 LLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNA--NEKTRLENQNLLIQVEEVSQTC 889
Query: 60 T-----NELLKSKFSENGN------QKNLRILSLELMKLRN---KRETKMRGMMAKQEGM 105
+ NE K E+ N QK LR EL+ L++ K + ++ + +
Sbjct: 890 SKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKEL 949
Query: 106 EMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYK 165
E K++ ++ +E + KI +++ V +KE + ET+ + E +E + DQ+
Sbjct: 950 EEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASM 1009
Query: 166 LDIAQLEENLK------EKNDEILSLKQ----SLEENIVILSKQVEDLNVKCQLLEKEKE 215
D+ Q E+ K EK E L +++ + E I L++Q+ + ++C+ + + E
Sbjct: 1010 RDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNE 1069
Query: 216 DHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEK-ELSSSLHQKL 274
D + R N L + ILE Q + + KEL+ + L +++K + ++ +L
Sbjct: 1070 DLLARIETLQSN-----AKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNEL 1124
Query: 275 CSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQA----------ERLVKQ--------- 315
Q ++ KEK ++L++T+ EL+ +++ +Q ERL+K+
Sbjct: 1125 EELQVQLQKEK----KQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKN 1180
Query: 316 -----LEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLL----QEKYDSMVQSL 366
LE+E K + ++ + L+E++ ++ +++ +T+ LL +E DS
Sbjct: 1181 NKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAET 1240
Query: 367 EDVTAQFESYKALTAS--EIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR 424
+ + Q L AS ++E K++ + + + K ++ + Q T S+ Q+ V
Sbjct: 1241 DHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVT 1300
Query: 425 MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA 484
LQ + + E +T F + N LKQQ+ Q E EG K E+E+
Sbjct: 1301 A---LQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAE-TEGAKQEREHL-- 1354
Query: 485 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNK-IRDSYAKLL 543
+L ++L K + Q L E Q L +EH E+ NK ++++ +K
Sbjct: 1355 ---------EMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSK-- 1403
Query: 544 GHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSK 603
L++K+ ++ EN +KSE ++ QL + + + + L +H +
Sbjct: 1404 -EAELREKL---CSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVE 1459
Query: 604 AFHHESKENFALKTPLKEGNTNCYRAPMECQESWK 638
+ + A LK T R+P+ Q+S K
Sbjct: 1460 TLQQQLSKMEAQLFQLKNEPTT--RSPVSSQQSLK 1492
Score = 97.8 bits (242), Expect = 3e-20
Identities = 134/633 (21%), Positives = 282/633 (44%), Gaps = 79/633 (12%)
Query: 5 IRVLLQERGAQDRRIQD--LETELEKMEARLNAALREKTSLSANNATLEKQLIELT-RTN 61
++ LL+++ +DRR + L+ L K + N L L LEK+ E + N
Sbjct: 909 LKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKIN 968
Query: 62 EL----LKSKFSENGNQKNLRILSLELMKLRNKRE---TKMRGMMAKQEG-----MEMKL 109
++ +K+K + ++K + + EL LR++++ MR ++ E +E +
Sbjct: 969 KIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEK 1028
Query: 110 QVTQRSLEESQG--------------KIAQLEGKLVSIEKEKIDEKSET----EKLLEY- 150
Q Q +E+ + + + L+ + ++ + E + + ET KLLE
Sbjct: 1029 QSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQ 1088
Query: 151 IEEISCASDQVEKYKLDIAQLEENLKEKN-----DEILSLKQSLEENIVILSKQVEDLNV 205
I E+ A V+K +L+ +L++ K K +E+ L+ L++ L K +++L +
Sbjct: 1089 ILEVQRAKAMVDK-ELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELEL 1147
Query: 206 ------KCQLLEKEKEDHVNRNREHNENL---NAEMQNLKQKFILEQQEREKLQQKELQI 256
+ L+ E D+ +E N+ L N ++++L+Q+ +++Q++E LQ++ +
Sbjct: 1148 VKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSL 1207
Query: 257 DSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQL 316
S +QQ +E ++ + Q L ++E+ K + L +L+ ++Q E QL
Sbjct: 1208 QSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQL 1267
Query: 317 EEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESY 376
E + + + E LK + +++ +A+ Q LQE+ + VT++FESY
Sbjct: 1268 AEITSEKHK----IHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESY 1323
Query: 377 KALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALK 436
K + ++ K N S+ + + K +E++ ML+D Q K L+
Sbjct: 1324 KVRVHNVLKQQK--NKSMSQAETEGAK--------------QEREHLEMLID-QLKIKLQ 1366
Query: 437 ETEIK-EITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRL 495
+++ +I VS LQ LQ++ E K L++ ++AE + E +
Sbjct: 1367 DSQNNLQINVSELQ---TLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKS 1423
Query: 496 LYEELYNK-TKPFQLQLDAFEVEKQALLNEH----GAAQEQLNKIRDSYAKLLGHQNLKQ 550
+ + ++ T ++ ++F + + L EH Q+QL+K+ +L +
Sbjct: 1424 EHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRS 1483
Query: 551 KIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSE 583
+ LK+ + +++ L +++ E
Sbjct: 1484 PVSSQQSLKNLRERRNTDLPLLDMHTVTREEGE 1516
Score = 94.0 bits (232), Expect = 4e-19
Identities = 133/606 (21%), Positives = 273/606 (45%), Gaps = 74/606 (12%)
Query: 56 ELTRTNELLKSKFSENGNQKNLRILSLEL-MKLRNKRETKMRGMMAKQEGMEMKLQV--- 111
EL + E L+SK G ++ L+ L L K ET+ + + K+E ++MK +V
Sbjct: 50 ELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDS 109
Query: 112 ------TQRSLEESQ----GKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQV 161
+ LE+S +I L+ +L+++ + ++K+ +K LE E ++ +
Sbjct: 110 VTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLE--EAMNTQLELS 167
Query: 162 EKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRN 221
E+ K E+N+K+ +EI ++ EE I+ L KQ++ + + + ++ + N
Sbjct: 168 EQLKFQ-NNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEAN 226
Query: 222 REH-NENLNAEMQNLKQKFILEQQEREKLQQKELQID-SLLQQEKELSSSLHQKLCSFQE 279
+H +N+N+ + L Q + Q+E ++L QI+ S + E E++ KL +E
Sbjct: 227 SQHYQKNINSLQEELLQLKAIHQEEVKELM---CQIEASAKEHEAEIN-----KLNELKE 278
Query: 280 EMVKEKNLFEEELKQTLD-ELDKLQQKEEQAER-------------LVKQ-LEEEAKSRA 324
+VK+ E+ +++ + EL+ L++ A + V+Q + E+ K
Sbjct: 279 NLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLE 338
Query: 325 EELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASE- 383
+ LK LE + + E+ + + + Q D ED+ +F+ + L A E
Sbjct: 339 DTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDL--EFKINELLLAKEE 396
Query: 384 ----IEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETE 439
IE LK E + L ++ E ++ + + +Q+ + L ++ L ++E
Sbjct: 397 QGCVIEKLKSELAGLNKQFC---YTVEQHNREVQSLKEQHQKEISEL----NETFLSDSE 449
Query: 440 IKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEE 499
+++T+ F +I L+ Q + +++ ++ + + E + E EL E K +E
Sbjct: 450 KEKLTLMF--EIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFES 507
Query: 500 LYNKTKPFQLQLDAFEVEK--QALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVK 557
+ Q D E+++ + E A E +N+++ KLL Q L ++++ +K
Sbjct: 508 MKQ-----QQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIK 562
Query: 558 -LKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLG-IKHFDPSKAFHHESKENFAL 615
L+++N +S+ L + + L EE + + +K+ HE +NF
Sbjct: 563 NLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKN-------SHEEMDNFHK 615
Query: 616 KTPLKE 621
K +E
Sbjct: 616 KCEREE 621
Score = 85.9 bits (211), Expect = 1e-16
Identities = 147/667 (22%), Positives = 278/667 (41%), Gaps = 121/667 (18%)
Query: 20 QDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNEL-------LKSKFSENG 72
Q +++ +++ +L A EK +L L+ + +L EL +K+ +NG
Sbjct: 510 QQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNG 569
Query: 73 ------NQKNLRILSLE-------------LMKLRNKRETKMRGMMAKQEGMEM------ 107
+Q++ + LE + KL+N E +M K E E
Sbjct: 570 VYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHE-EMDNFHKKCEREERLILELG 628
Query: 108 -KLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 166
K++ T + E + K+ +L G L KEK + EKL+ ++ +S + E
Sbjct: 629 KKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLS---EDKEVLSA 685
Query: 167 DIAQLEENLKEKNDEILSLKQSLE-----ENIVILSKQVEDLNVKCQLLEKEKEDHVNRN 221
++ L E + + E L + LE + VIL + + L K QL+ +E +D++N+
Sbjct: 686 EVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEE-QDNLNKL 744
Query: 222 REHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCS--FQE 279
E+ + ++ F+ E +E + ++LQ E + ++++ C+ FQ
Sbjct: 745 LENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQR 804
Query: 280 -----EMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELK--LLEE 332
E+ KE +EE +EL L + EQ + L+++ EE +S E L+ LLE
Sbjct: 805 DEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEM 864
Query: 333 KLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDV--------TAQFESYKALTAS-E 383
K ++ LE + LL+Q + S S ++ + E+ K L E
Sbjct: 865 KNANEKTRLENQN-------LLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKE 917
Query: 384 IEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEI 443
+ D + E L++ AK+ D SS +E + +L+ + KE +I +I
Sbjct: 918 LRDRRAELILLKDSLAKSPSVKNDPL-------SSVKELEEKIENLEKECKEKEEKINKI 970
Query: 444 TVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNK 503
+ ++ +L + K+ + E+ E ++EK+ +A + + I E N
Sbjct: 971 KLVAVKAKKELDSSRKETQT----VKEELESLRSEKDQLSASMRDLIQG----AESYKNL 1022
Query: 504 TKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSY-----------------------A 540
++ Q + +VEK+ N ++ ++R+S A
Sbjct: 1023 LLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNA 1082
Query: 541 KLLGHQNLK--------------QKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKL 586
KLL Q L+ +K++ K+K E++ +E+ +L+ QL K+K+ K
Sbjct: 1083 KLLEVQILEVQRAKAMVDKELEAEKLQKEQKIK-EHATTVNELEELQVQLQKEKKQLQKT 1141
Query: 587 QEELNKV 593
+EL V
Sbjct: 1142 MQELELV 1148
Score = 85.1 bits (209), Expect = 2e-16
Identities = 119/584 (20%), Positives = 255/584 (43%), Gaps = 80/584 (13%)
Query: 47 NATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGME 106
+AT +++ +T+ ++++ + QKN+ L EL++L+ + +++ +M + E
Sbjct: 206 DATTDEKKETVTQLQNIIEA--NSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEA-- 261
Query: 107 MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 166
S +E + +I KL +++ + + +EK ++ +KY+
Sbjct: 262 --------SAKEHEAEI----NKLNELKENLVKQCEASEKNIQ------------KKYEC 297
Query: 167 DIAQLEENLKEKNDEILSLKQSLEENIV---ILSKQVEDLNVKCQLLEKEK---EDHVNR 220
++ L + N + L+EN +++++V+ L + LE + +D V
Sbjct: 298 ELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTY 357
Query: 221 NREHNENLNAEMQNLKQKFILEQQE-----REKLQQKELQIDSLLQQEKELSSSLHQKLC 275
L + Q++K +F E+++ E L KE Q ++++ K + L+++ C
Sbjct: 358 MNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQ-GCVIEKLKSELAGLNKQFC 416
Query: 276 SFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLK 335
E+ +E +E+ ++ + EL++ + + E+L E++ L+E+ +
Sbjct: 417 YTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMF---------EIQGLKEQCE 467
Query: 336 GKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLK------- 388
+ E +++ + +++ + +S ++ +FES K AS++ +L+
Sbjct: 468 NLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAF 527
Query: 389 LENSSLQEKAAK-AGKNAEDVQHQILATESSN-------QEYVRMLLDLQTKSALKETEI 440
E +L E + G+N + + Q L E N + V +L Q + LKE E
Sbjct: 528 TEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEG 587
Query: 441 KEITVSFLQKITDLQNQLKQQEED---FRKQLEDEE------GRKAEKE-NTTAELTEEI 490
K S ++ D N+LK E+ F K+ E EE G+K E+ +EL +++
Sbjct: 588 K--INSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKV 645
Query: 491 NKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQ 550
N+ EE + +L+ V+ + L + ++ + + KL +
Sbjct: 646 NELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLS 705
Query: 551 KIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVL 594
+ V + E+ LK ++ QL KK Q + Q+ LNK+L
Sbjct: 706 RDLEVFLSQKEDVILKEHIT----QLEKKLQLMVEEQDNLNKLL 745
Score = 77.4 bits (189), Expect = 4e-14
Identities = 138/612 (22%), Positives = 251/612 (41%), Gaps = 89/612 (14%)
Query: 50 LEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKL 109
LE L EL + +LK + + N K L LE+ K E ++E +E K+
Sbjct: 337 LEDTLKELESQHSILKDEVTYMNNLK----LKLEMDAQHIKDE-----FFHEREDLEFKI 387
Query: 110 QVTQRSLEESQGKIAQLEGKLVSIEKE---KIDE--------KSETEKLLEYIEEISCAS 158
+ EE I +L+ +L + K+ +++ K + +K + + E +
Sbjct: 388 NELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSD 447
Query: 159 DQVEKYKL--DIAQLEE---NLKEKNDEILSLKQSLEENIVILSKQV-EDLNVKCQLLEK 212
+ EK L +I L+E NL+++ E + +SL E + IL ++ E Q E
Sbjct: 448 SEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFES 507
Query: 213 EKEDHVNRNREHNENLNA---EMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSS- 268
K+ + E + L E L + Q E EKL ++ + L K L
Sbjct: 508 MKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEK 567
Query: 269 ------SLHQKLCSFQE------EMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQL 316
SL Q+ +E + +EK+ F +LK + +E+D +K E+ ERL+ +L
Sbjct: 568 NGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILEL 627
Query: 317 EEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFE-- 374
++ + + LE+K+ LE++ L+EK D Q LE + Q +
Sbjct: 628 GKKVEQTIQYNSELEQKVNELTGGLEET----------LKEK-DQNDQKLEKLMVQMKVL 676
Query: 375 -SYKALTASEIEDLKLENSSLQEKAAKAGKNAE---DVQHQILATESSNQEYVRMLLDLQ 430
K + ++E++ L EN+ L + + ++ E + ++ E Q ++ L ++
Sbjct: 677 SEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVE 736
Query: 431 TKSAL-KETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEE 489
+ L K E +++ F +K Q F K++ E +E+++ L
Sbjct: 737 EQDNLNKLLENEQVQKLF----------VKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAV 786
Query: 490 INKWRLLYEELYNKTKPFQLQLDAFEVEKQ-ALLNEHGAAQ-EQLNKIRDSYAKLLGHQN 547
+ EE N FQ E+EK+ L E Q E+L + Y
Sbjct: 787 GESLAKINEEKCNLA--FQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYE------- 837
Query: 548 LKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQ-EELNKVLGIKHFDP--SKA 604
+ V L+ E +++SE L+ L + K + K + E N ++ ++ SK+
Sbjct: 838 -----QEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKS 892
Query: 605 FHHESKENFALK 616
H KE +K
Sbjct: 893 EIHNEKEKCFIK 904
Score = 68.2 bits (165), Expect = 2e-11
Identities = 102/539 (18%), Positives = 235/539 (43%), Gaps = 66/539 (12%)
Query: 88 RNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKL 147
++K ET + + K +M L +++++ + +LE ++ E++ K TE
Sbjct: 19 KSKLETLPKEDLIKFAKKQMML------IQKAKSRCTELEKEI-----EELRSKPVTEGT 67
Query: 148 LEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKC 207
+ I+ ++ ++++ L+ A+ E+ E + +KQ +E+++ + ++L
Sbjct: 68 GDIIKALT---ERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKEL---- 120
Query: 208 QLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELS 267
++ H+N +E ENL E+ ++ K+ ++ +K ++ + L ++ +
Sbjct: 121 ------EQSHINYVKEI-ENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQ 173
Query: 268 SSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD-KLQQKEEQAERLVKQLEEEAK----- 321
++ + QEE+ K + FEE++ +LD +K+E +L +E ++
Sbjct: 174 NNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKN 233
Query: 322 --SRAEELKLL----EEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLE-------- 367
S EEL L +E++K ++E S+ H L E +++V+ E
Sbjct: 234 INSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQK 293
Query: 368 DVTAQFESYKALTASEIED------LKLENSSLQEKAAKAGKNAEDVQHQILATESSNQE 421
+ E+ + T++ +D L EN+ +++ + K+ ED ++ + S ++
Sbjct: 294 KYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKD 353
Query: 422 YVRMLLDLQTKSALKETEIKEITVSFLQKITDLQ---NQLKQQEEDFRKQLEDEEGRKAE 478
V + +L+ K + IK+ F + DL+ N+L +E+ +E + A
Sbjct: 354 EVTYMNNLKLKLEMDAQHIKD---EFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAG 410
Query: 479 KENTTAELTEEINKWRLLYEELYNK--TKPFQLQLDAFEVEKQALLNEHGAAQEQLNKI- 535
E+ N+ +E + K ++ + L E EK L+ E +EQ +
Sbjct: 411 LNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQ 470
Query: 536 RDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVL 594
++ +L +++L++ ++ + ++L K+ + KQ + EL + L
Sbjct: 471 QEKQEAILNYESLREIMEIL------QTELGESAGKISQEFESMKQQQASDVHELQQKL 523
Score = 60.1 bits (144), Expect = 6e-09
Identities = 100/488 (20%), Positives = 215/488 (44%), Gaps = 68/488 (13%)
Query: 4 LIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLE------KQLIEL 57
L++ L Q+ ++ +I+DLE E++ + + E TSL ++ E KQL+
Sbjct: 1168 LMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVK 1227
Query: 58 TRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKL-QVTQRSL 116
T+ EL SK +E + L EL + + E + +A+ + K+ + + S
Sbjct: 1228 TK-KELADSKQAETDHLILQASLKGELEASQQQVEV-YKIQLAEITSEKHKIHEHLKTSA 1285
Query: 117 EESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL---DIAQLEE 173
E+ Q ++ + ++ ++++E K+E + + + E YK+ ++ + ++
Sbjct: 1286 EQHQRTLSAYQQRVTALQEECRAAKAEQ----------ATVTSEFESYKVRVHNVLKQQK 1335
Query: 174 NLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLN-AEM 232
N E KQ E L ++ L +K Q + ++N +N +E+
Sbjct: 1336 NKSMSQAETEGAKQEREH----LEMLIDQLKIKLQ------------DSQNNLQINVSEL 1379
Query: 233 QNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEEL 292
Q L Q E + L ++ + +LQ+ + L +KLCS Q E + + + E
Sbjct: 1380 QTL-------QSEHDTLLERH---NKMLQETVSKEAELREKLCSIQSENM----MMKSEH 1425
Query: 293 KQTLDELDKLQQKEEQAER-LVKQLEEEAKSRAEELKLLEEKLKGKEAELE-----KSSA 346
QT+ +L + + R V+ L+EE + E L+ K++ + +L+ +S
Sbjct: 1426 TQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPV 1485
Query: 347 AHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAE 406
+ Q+ L+E+ ++ + L+ T E + + ++ E + ++ Q
Sbjct: 1486 SSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPET 1545
Query: 407 DVQHQILATESSNQEYVRMLLDLQTKSA------LKETEIKEITVSFLQKITDLQNQLKQ 460
++ + E + +E V+ L TKSA L+ETE + +++I L++++++
Sbjct: 1546 KLEPPLWHAEFTKEELVQK-LSSTTKSADHLNGLLRETEATNAIL--MEQIKLLKSEIRR 1602
Query: 461 QEEDFRKQ 468
E + ++
Sbjct: 1603 LERNQERE 1610
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 119 bits (298), Expect = 9e-27
Identities = 126/549 (22%), Positives = 257/549 (46%), Gaps = 56/549 (10%)
Query: 85 MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKID--- 139
MKL K + ++ ++E MK Q T+ L +S+ K +LE KLV++ +EK D
Sbjct: 831 MKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQL 890
Query: 140 -EKSETEKLL---EYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVI 195
++E+E LL E +++ A Q+E ++ + E+ +E N E+ + K+ LE+
Sbjct: 891 QVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 950
Query: 196 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQ 255
L K ++DL + +EKEK H N+ +NL E+ L + +E++ LQ+ Q
Sbjct: 951 LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEELSGLDETIAKLTREKKALQEAHQQ 1006
Query: 256 IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 315
LQ E++ +SL++ ++++ ++ E+E K +D L++ + + E +K
Sbjct: 1007 ALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVD----LERNKRKLEGDLKL 1062
Query: 316 LEEEAKSRAEELKLLEEKLKGKEAE-LEKSSAAHTQATLLLQ-----EKYDSMVQSLEDV 369
+E + + L+E+LK K+ E + S + TL LQ ++ + ++ LE+
Sbjct: 1063 AQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEE 1122
Query: 370 TAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDL 429
+ +A T + D E L E+ +AG QI + E++++ DL
Sbjct: 1123 IEAERATRAKTEKQRSDYARELEELSERLEEAGGVTST---QIELNKKREAEFLKLRRDL 1179
Query: 430 QTKSALKETEIKEITVSFLQKITDLQNQ----------LKQQEEDFRKQLEDEEG----- 474
+ + E + + + +L Q L++++ +F+ +++D
Sbjct: 1180 EEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESV 1239
Query: 475 --RKAEKENTTAELTEEINKWRLLYEELYNK-----TKPFQLQLDAFEVEKQALLNEHGA 527
KA E L +++++ R EE+ T+ +LQ +A E+ +Q L E +
Sbjct: 1240 SKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQ--LEEKES 1297
Query: 528 AQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL----KSEVSKLRCQLAKKKQSE 583
QL++ + ++ + + LK++++ K K+ + + + LR Q ++++ +
Sbjct: 1298 IVSQLSRSKQAFTQQT--EELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGK 1355
Query: 584 TKLQEELNK 592
+LQ L+K
Sbjct: 1356 AELQRALSK 1364
Score = 108 bits (271), Expect = 1e-23
Identities = 149/669 (22%), Positives = 292/669 (43%), Gaps = 101/669 (15%)
Query: 16 DRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQK 75
++ + + E++ + + + + + K +L TLE QL E NE ++ SE QK
Sbjct: 1219 EKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQK 1278
Query: 76 N-LRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVS-- 132
+ L+ + EL + ++E+ + + ++ + + +R LEE L L S
Sbjct: 1279 SRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSR 1338
Query: 133 ----IEKEKIDEKSETEKLLEYIEEISCASDQV----EKYKLDIAQLEENLKEKNDEILS 184
+ +E+ +E+ E + L+ +S A+ +V KY+ D Q E L+E ++
Sbjct: 1339 HDCDLLREQYEEEQEGKAELQ--RALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1396
Query: 185 LKQSLEENIVILSKQVEDLNVKCQLLEKEKE------DHVNRNREHNENLNAEMQNLKQK 238
Q EE QVE +N KC LEK K+ + + + E +L A + ++
Sbjct: 1397 RLQDSEE-------QVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRN 1449
Query: 239 FILEQQE-REKLQQKELQIDSLLQQEKELSSSLHQKLCSFQE-----EMVK--EKNLFEE 290
F E + K ++ + ++++ L++ + LS+ L + +++E E VK KNL +E
Sbjct: 1450 FDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQE 1509
Query: 291 ---------ELKQTLDELDKLQQKEEQAERLVKQL---EEEAKSRAEELKLL-------- 330
E +T+ EL+K +K+ + E+ QL E EA EE K+L
Sbjct: 1510 IADLTEQIAENGKTIHELEK-SRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQ 1568
Query: 331 -----EEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIE 385
+ K+ K+ E+E+ + + +Q D+ V+S + K ++
Sbjct: 1569 VKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAI----RLKKKMEGDLN 1624
Query: 386 DLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITV 445
+++++ S +AA+ K+ VQ Q+ T+ + +R DL+ + A+ E
Sbjct: 1625 EIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERR------ 1678
Query: 446 SFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEI-----NKWRLLYEEL 500
N L+ + E+ R LE E + E + E + L++ +
Sbjct: 1679 ---------ANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKK 1729
Query: 501 YNKTKPFQLQLDAFEVEKQALLNEHGAAQ---------EQLNKIRDSYAKL-LGHQNLKQ 550
+T QLQ + + + A E A + E+L K +D+ A L +NL+Q
Sbjct: 1730 KLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQ 1789
Query: 551 KIKHVVKLKDENSQL-----KSEVSKLRCQLAKKK-QSETKLQEELNKVLGIKHFDPS-K 603
+K + DE QL K ++ KL ++ + + + E + ++ V G++ ++ K
Sbjct: 1790 TVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVK 1849
Query: 604 AFHHESKEN 612
++S+E+
Sbjct: 1850 ELTYQSEED 1858
Score = 101 bits (251), Expect = 2e-21
Identities = 124/647 (19%), Positives = 287/647 (44%), Gaps = 70/647 (10%)
Query: 1 MTLLIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRT 60
+T R L E + I DLE L K+E +A + +L+ + L++ + +LTR
Sbjct: 937 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTRE 996
Query: 61 NELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQ 120
+ L + +Q+ L L E K+ + +TK + + + E +E L+ ++ + +
Sbjct: 997 KKAL-----QEAHQQALDDLQAEEDKVNSLNKTKSK-LEQQVEDLESSLEQEKKLRVDLE 1050
Query: 121 GKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND 180
+LEG L ++ +D +++ ++L ++++K + QL+ ++++
Sbjct: 1051 RNKRKLEGDLKLAQESILDLENDKQQL----------DERLKKKDFEYCQLQSKVEDEQT 1100
Query: 181 EILSLKQSLEE---NIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENL--------- 228
L ++ ++E I L +++E EK++ D+ E +E L
Sbjct: 1101 LGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTST 1160
Query: 229 NAEMQNLKQ-KFI-LEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQ---EEMVK 283
E+ ++ +F+ L + E Q E + +L ++ + + L +++ + Q +++ K
Sbjct: 1161 QIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEK 1220
Query: 284 EKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEE---EAKSRAEELKLLEEKLKGKEAE 340
EK+ F+ E+ ++ + + + E++ + LE+ EA+ + EE++ +L +++
Sbjct: 1221 EKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSR 1280
Query: 341 LEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAK 400
L+ + + + L+EK +S+V L F ++E+ ++L
Sbjct: 1281 LQTEAG---ELSRQLEEK-ESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQS 1336
Query: 401 AGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQ 460
+ + + ++ Q + E R L ++ A T+ + + +++ + + +L Q
Sbjct: 1337 SRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1396
Query: 461 QEEDFRKQLEDEEGRKAEKENT-------TAELTEEINKWRLLYEELYNKTKPF------ 507
+ +D +Q+E + A E T +L ++ + L L K + F
Sbjct: 1397 RLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAE 1456
Query: 508 -QLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG--------HQNLKQKIKHVVKL 558
+ + + + E +A L E + +L K++++Y + L ++NL+Q+I + +
Sbjct: 1457 WKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQ 1516
Query: 559 KDENSQLKSEVSKLRCQLAKKK--------QSETKLQEELNKVLGIK 597
EN + E+ K R Q+ +K ++E L+ E K+L I+
Sbjct: 1517 IAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQ 1563
Score = 94.0 bits (232), Expect = 4e-19
Identities = 131/635 (20%), Positives = 280/635 (44%), Gaps = 60/635 (9%)
Query: 17 RRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKN 76
++I++L+ +E++E + A A A EKQ + R E L + E G +
Sbjct: 1107 KKIKELQARIEELEEEIEAE-------RATRAKTEKQRSDYARELEELSERLEEAGGVTS 1159
Query: 77 LRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG-KIAQLEGKLVSIEK 135
+I +L KRE + + E ++ + +L + +A+L ++ ++++
Sbjct: 1160 TQI------ELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQR 1213
Query: 136 EKID-EKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIV 194
K EK ++E LE I+++S + + V K K ++ ++ L+++ E + ++ ++
Sbjct: 1214 VKQKLEKEKSEFKLE-IDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLS 1272
Query: 195 ILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKEL 254
L+ Q L + ++R E E++ +++ KQ F + +E ++ ++E
Sbjct: 1273 ELTTQKSRLQTEA--------GELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEEN 1324
Query: 255 QIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVK 314
+ + L L SS H C E +E+ + EL++ L + + E A+ K
Sbjct: 1325 KAKNALAHA--LQSSRHD--CDLLREQYEEEQEGKAELQRALSKANS-----EVAQWRTK 1375
Query: 315 QLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFE 374
E +A R EEL+ ++KL + + E+ A L++ + +ED+ E
Sbjct: 1376 Y-ETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVE 1434
Query: 375 SYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSA 434
+L A+ + + + L E K ++ +++ + + S + E + L + A
Sbjct: 1435 RANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFK--LKNAYEEA 1492
Query: 435 LKETE-IKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRK-AEKENTTAELTEEINK 492
L + E +K + Q+I DL Q+ + + E E+ RK E E +L E +
Sbjct: 1493 LDQLETVKRENKNLEQEIADLTEQIAENGKTIH---ELEKSRKQIELEKADIQLALEEAE 1549
Query: 493 WRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKI 552
L +EE K ++QL+ +V K + + E++ +++ +Y + + + ++ +
Sbjct: 1550 AALEHEE----AKILRIQLELTQV-KSEIDRKIAEKDEEIEQLKRNYQRTV--ETMQSAL 1602
Query: 553 KHVVKLKDENSQLK----SEVSKLRCQLAKKKQSETKLQEELNKVLG-IK----HFDPSK 603
V+ ++E +LK +++++ QL+ + + + L V G +K H D +
Sbjct: 1603 DAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDAL 1662
Query: 604 AFHHESKENFAL---KTPLKEGNTNCYRAPMECQE 635
+ KE A+ + L + RA +E E
Sbjct: 1663 RGQEDLKEQLAIVERRANLLQAEVEELRATLEQTE 1697
Score = 63.9 bits (154), Expect = 4e-10
Identities = 82/381 (21%), Positives = 172/381 (45%), Gaps = 47/381 (12%)
Query: 8 LLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSK 67
L Q + DR+I + + E+E+++ + +T SA +A E+ NE ++ K
Sbjct: 1566 LTQVKSEIDRKIAEKDEEIEQLKRNYQRTV--ETMQSALDA-------EVRSRNEAIRLK 1616
Query: 68 FSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLE 127
G+ L + ++L + ++ + + Q +L+ TQ L+++ L+
Sbjct: 1617 KKMEGD---LNEIEIQLSHANRQAAETLKHLRSVQG----QLKDTQLHLDDALRGQEDLK 1669
Query: 128 GKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQ 187
+L +E+ ++E E+L +E+ A E+ LD + + L +N ++ K+
Sbjct: 1670 EQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKK 1729
Query: 188 SLEENIVILSKQVEDLNVKCQLLEKEKE----------DHVNRNREHNENLNAEMQNLKQ 237
LE +++ L +VED + + E++ + + + + ++ + +L +NL+Q
Sbjct: 1730 KLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQ 1789
Query: 238 -----KFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQ---------KLCSFQEEMVK 283
+ L++ E+ L+ + QI L + +EL L K E VK
Sbjct: 1790 TVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVK 1849
Query: 284 EKNLFEEELKQTL----DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA 339
E EE ++ + D +DKLQ K + +R ++ +E+A + + + + +L +EA
Sbjct: 1850 ELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHEL--EEA 1907
Query: 340 ELEKSSAAHTQATLLLQEKYD 360
E E++ A +Q L + D
Sbjct: 1908 E-ERADIAESQVNKLRAKTRD 1927
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 119 bits (298), Expect = 9e-27
Identities = 167/692 (24%), Positives = 296/692 (42%), Gaps = 120/692 (17%)
Query: 4 LIRVLLQERGAQDRRIQDLE----TELEKMEARLNAALREKTSLSANNATLEKQLIELTR 59
L + L +E + +IQD+ T LE++ +L A R K +L N LE EL
Sbjct: 1179 LKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELAC 1238
Query: 60 TNELLKSKFSENGNQKN------------------LRI-LSLELMKLRNK--------RE 92
++L+ +E+ +++ LR+ L+ + KL+N+ E
Sbjct: 1239 EVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEE 1298
Query: 93 TKMRGMMAKQEG--MEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEY 150
+ +G+ ++ +E +LQ TQ L+E + L ++ +E+EK L E
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEK-------NSLQEQ 1351
Query: 151 IEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLL 210
EE A +EK L + + K+K D+ L +SLEE L K E L+ + +
Sbjct: 1352 QEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLE-- 1409
Query: 211 EKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSL 270
EK ++ + L E+ +L ++Q L++K+ + D LL +EK +S+
Sbjct: 1410 --EKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARY 1467
Query: 271 HQK-----------------LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLV 313
++ L EE ++ K FE + KQ +++ L ++ + V
Sbjct: 1468 AEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNV 1527
Query: 314 KQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQF 373
+LE+ ++ ++++ + +L+ E EL+ + A + + +Q + L+ Q
Sbjct: 1528 HELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQN 1587
Query: 374 ESYKALTASEIEDL--KLENSSLQEKAAKAGK-----NAEDVQHQILATESSNQEYVRML 426
E K L ++ +L +LE+ Q A A K + +D++ QI A + E ++ L
Sbjct: 1588 EEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQL 1647
Query: 427 LDLQTKSALKETEIKEITVS----FLQ-------------KITDLQNQLKQQE------E 463
LQ + + E++E S F Q +I LQ +L E E
Sbjct: 1648 RKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAE 1707
Query: 464 DFRKQLEDE-----EGRKA---EK---ENTTAELTEEINKWRLLYEELYNKTKPFQLQLD 512
R +L DE G+ A EK E A+L EE+ + + E L ++ + LQ+D
Sbjct: 1708 QERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVD 1767
Query: 513 AFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN--LKQKIKHV-----VKLKDENSQL 565
E L E AAQ+ D+ + L QN LK K++ + K K S L
Sbjct: 1768 TLNAE---LAAERSAAQKS-----DNARQQLERQNKELKAKLQELEGAVKSKFKATISAL 1819
Query: 566 KSEVSKLRCQL---AKKKQSETKLQEELNKVL 594
++++ +L QL AK++ + KL K L
Sbjct: 1820 EAKIGQLEEQLEQEAKERAAANKLVRRTEKKL 1851
Score = 101 bits (251), Expect = 2e-21
Identities = 127/597 (21%), Positives = 272/597 (45%), Gaps = 49/597 (8%)
Query: 6 RVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN---- 61
++L E+ IQDLE +L++ E EK + A +E++++ L N
Sbjct: 939 QILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFI 998
Query: 62 ---ELLKSKFSENGNQ-KNLRILSLELMKLRNKRETKMRGM---MAKQEGMEMKLQVTQR 114
+L++ + +E +Q + L K+RNK+E + + + K+E +L+ +R
Sbjct: 999 KEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKR 1058
Query: 115 SLE----ESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISC----ASDQVEKYKL 166
L+ + Q +IA+L+ ++ ++ + ++ E + L ++ + A V + +
Sbjct: 1059 KLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQA 1118
Query: 167 DIAQLEENL---KEKNDEILSLKQSLEENIVILSKQVE---DLNVKCQLLEKEKEDHVNR 220
IA+L+E+ K ++ K+ L E + L ++E D Q L ++E V
Sbjct: 1119 QIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAE 1178
Query: 221 NR----EHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCS 276
+ E +N A++Q+++Q+ +E + ++ + + L++ K+ + +++L
Sbjct: 1179 LKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELAC 1238
Query: 277 FQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKG 336
+ + + K E + K+ ++ +L K + +RL +L E+A EL + L
Sbjct: 1239 EVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLL-- 1296
Query: 337 KEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQE 396
+EAE + A A+L +S +Q +++ + K +S I L+ E +SLQE
Sbjct: 1297 EEAEKKGIKFAKDAASL------ESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQE 1350
Query: 397 KAAKAGKNAEDVQHQILATESSNQEYVRML-LDLQTKSALKETEIKEITVSFLQKITDLQ 455
+ + + ++++ Q+LA +S + + + DL T +L+E + +K+
Sbjct: 1351 QQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAK---------KKLLKDA 1401
Query: 456 NQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFE 515
L Q+ E+ + E K + +LT +++ R + L K K F QL A E
Sbjct: 1402 EALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFD-QLLAEE 1460
Query: 516 VEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKL 572
A E E + +++ A L + L++ ++ + + +N QL++++ L
Sbjct: 1461 KSISARYAEERDRAEAEAREKETKALSLA-RALEEALEAKEEFERQNKQLRADMEDL 1516
Score = 100 bits (248), Expect = 5e-21
Identities = 163/704 (23%), Positives = 303/704 (43%), Gaps = 109/704 (15%)
Query: 22 LETELEKMEARLNAALREKTSLSAN--------------NATLEKQLIELTRTNELLKSK 67
+E ELE+ME + L EK L+ A L + EL L+S+
Sbjct: 871 VEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESR 930
Query: 68 FSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLE 127
E ++ +IL E K++ + + + ++EG KLQ+ + + E KI ++E
Sbjct: 931 VEE--EEERNQILQNEKKKMQAHIQ-DLEEQLDEEEGARQKLQLEKVTAE---AKIKKME 984
Query: 128 GKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVE-------------KYKLDIAQLEEN 174
+++ +E + + K EK L C+S E K ++ I+ LEE
Sbjct: 985 EEILLLEDQ--NSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEER 1042
Query: 175 LKEK---NDEILSLKQSLEENIVILSKQVEDL-----NVKCQLLEKEKE----------- 215
LK++ E+ K+ L+ L Q+ +L +K QL +KE+E
Sbjct: 1043 LKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDE 1102
Query: 216 -DHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEK-ELSSSL--- 270
H N + L A++ L++ F E+ R K ++++ + L+ K EL +L
Sbjct: 1103 TLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTT 1162
Query: 271 --HQKLCSFQEEMVKE-KNLFEEELKQTLDELDKLQQKEEQA-ERLVKQLEEEAKSRAEE 326
Q+L + +E+ V E K EEE K ++ ++Q+ A E L +QLE+ + +A
Sbjct: 1163 AAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKAN- 1221
Query: 327 LKLLEEKLKGKEAELEKSSAAHTQATLLL-------QEKYDSMVQSLEDVTAQFESYKAL 379
LE+ +G E + K A + + ++K D+ VQ L ++ + +
Sbjct: 1222 ---LEKNKQGLETD-NKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVE 1277
Query: 380 TASEIEDL--KLEN-SSLQEKAAKAG----KNAEDVQHQILATESSNQEYVRMLLDL--- 429
A + L +L+N S+L E+A K G K+A ++ Q+ T+ QE R L+L
Sbjct: 1278 LAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSR 1337
Query: 430 -----QTKSALKE--TEIKEITVSFLQKITDLQNQL---KQQEEDFRKQLEDEEGRKAEK 479
+ K++L+E E +E + +++ LQ+QL K++ +D +E E K +
Sbjct: 1338 IRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKL 1397
Query: 480 ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSY 539
L++ + + L Y++L Q +LD V+ L+ L K + +
Sbjct: 1398 LKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVD----LDHQRQVASNLEKKQKKF 1453
Query: 540 AKLLGHQN------LKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSE---TKLQEEL 590
+LL + +++ + + +++ ++ S L L K++ E +L+ ++
Sbjct: 1454 DQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADM 1513
Query: 591 NKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQ 634
++ K D K H K AL+ ++E T E Q
Sbjct: 1514 EDLMSSKD-DVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQ 1556
Score = 96.7 bits (239), Expect = 6e-20
Identities = 146/656 (22%), Positives = 293/656 (44%), Gaps = 96/656 (14%)
Query: 9 LQERGAQ-DRRIQDLETELEKMEARLNAALR--EKTSLSANNAT-----LEKQLIELTRT 60
LQ++ A+ +I +L+ +L K E L AL + +L NNA L+ Q+ EL
Sbjct: 1067 LQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQED 1126
Query: 61 NELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQ 120
E K S N +K R LS EL L+ + E + A+QE T+R E ++
Sbjct: 1127 FE--SEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELR------TKREQEVAE 1178
Query: 121 GKIAQLEGKLVSIEKEKIDEKSETEKLLEY----IEEISCASDQVEKYKLDIAQLEENLK 176
K A +E+E + +++ + + + +EE+S +Q +++K ++ + ++ L+
Sbjct: 1179 LKKA--------LEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLE 1230
Query: 177 EKNDEIL-------SLKQSLEENIVILSKQVEDLNVKCQ---LLEKEKEDHVNRNREHNE 226
N E+ +K E L QV++L+ K L E + ++ + +
Sbjct: 1231 TDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELD 1290
Query: 227 NLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEM--VKE 284
N++ ++ ++K I ++ L+ + LLQ+E +L ++ +EE ++E
Sbjct: 1291 NVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQE 1350
Query: 285 KNLFEEELKQTLD--------ELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKG 336
+ EEE ++ L+ +L ++K + ++ LEE K ++ + L ++L+
Sbjct: 1351 QQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEE 1410
Query: 337 KEAELEKSSAAHTQATLLLQEKYDSMV----------QSLEDVTAQFESY----KALTAS 382
K +K + LQ++ D + +LE +F+ K+++A
Sbjct: 1411 KALAYDKLEKTKNR----LQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISAR 1466
Query: 383 EIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKET---- 438
E+ + +EK KA A ++ + A E ++ ++ D++ + K+
Sbjct: 1467 YAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKN 1526
Query: 439 --EIKEITVSFLQKITDLQNQLKQQE------EDFRKQLE-DEEGRKAEKEN---TTAEL 486
E+++ + Q++ +++ QL++ E ED + +LE + + KA+ E T E
Sbjct: 1527 VHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQ 1586
Query: 487 TEE-----INKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAK 541
EE I + R L EL ++ K L + A + + + L + A E NK RD K
Sbjct: 1587 NEEKKRLLIKQVRELEAELEDERKQRALAV-ASKKKMEIDLKDLEAQIEAANKARDEVIK 1645
Query: 542 LLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIK 597
L + L+ ++K + +E + E+ A+ K+SE KL+ ++L ++
Sbjct: 1646 QL--RKLQAQMKDYQRELEEARASRDEI------FAQSKESEKKLKSLEAEILQLQ 1693
Score = 87.0 bits (214), Expect = 5e-17
Identities = 120/503 (23%), Positives = 234/503 (46%), Gaps = 73/503 (14%)
Query: 109 LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKL----LEYIEEISCASDQVEKY 164
LQVT++ EE Q K + +L+ +++++ + E E++ + +EE + ++Q++
Sbjct: 845 LQVTRQE-EELQAK----DEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAE 899
Query: 165 KLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREH 224
A+ EE + + KQ LEE + L +VE+ + Q+L+ EK+
Sbjct: 900 TELFAEAEE----MRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKK--------- 946
Query: 225 NENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKE 284
+ A +Q+L+++ E+ R+KLQ +++ ++ +++ +E L + F +KE
Sbjct: 947 --KMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKF----IKE 1000
Query: 285 KNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKE---AEL 341
K L E+ + + + L ++EE+A+ L K ++ ++ LEE+LK +E EL
Sbjct: 1001 KKLMEDRIAECSSQ---LAEEEEKAKNLAKIRNKQEVMISD----LEERLKKEEKTRQEL 1053
Query: 342 EKSSAAHTQATLLLQEKYDSMVQSLEDVTAQF-----ESYKALTASEIEDLKLENS--SL 394
EK+ T LQ++ + ++++ Q E AL + E L N+ +
Sbjct: 1054 EKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVV 1113
Query: 395 QEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDL 454
+E A+ + ED + + ++S + + DL + +TE+++ T+ +L
Sbjct: 1114 RELQAQIAELQEDFESE----KASRNKAEKQKRDLSEELEALKTELED-TLDTTAAQQEL 1168
Query: 455 QNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF 514
+ + +Q+ + +K LE+ E +N A++ + + EEL + + +
Sbjct: 1169 RTKREQEVAELKKALEE------ETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANL 1222
Query: 515 EVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQ----LKSEVS 570
E KQ L E NK K+L Q +K + +H K D Q SE
Sbjct: 1223 EKNKQGL--------ETDNKELACEVKVL--QQVKAESEHKRKKLDAQVQELHAKVSEGD 1272
Query: 571 KLRCQLAKKKQSETKLQEELNKV 593
+LR +LA+K +KLQ EL+ V
Sbjct: 1273 RLRVELAEK---ASKLQNELDNV 1292
Score = 70.9 bits (172), Expect = 3e-12
Identities = 89/399 (22%), Positives = 179/399 (44%), Gaps = 66/399 (16%)
Query: 5 IRVLLQERGAQDRRIQDLETELEKMEARLNAA----LREKTSLSANNATLEKQLIELTRT 60
+ L + + A +++++++ T+LE++E L A LR + ++ A A E+ L
Sbjct: 1527 VHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQ 1586
Query: 61 NEL-----------LKSKFSENGNQKNLRILSLELMKLRNK-------RETKMRGMMAKQ 102
NE L+++ + Q+ L + S + M++ K K R + KQ
Sbjct: 1587 NEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ 1646
Query: 103 -EGMEMKLQVTQRSLEES---------------------QGKIAQLEGKLVSIEKEKIDE 140
++ +++ QR LEE+ + +I QL+ +L S E+ +
Sbjct: 1647 LRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHA 1706
Query: 141 KSETEKLLEYIEEI----SCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVIL 196
+ E ++L + I S D+ + + IAQLEE L+E+ + L + +
Sbjct: 1707 EQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTL-- 1764
Query: 197 SKQVEDLNVK--CQLLEKEKEDHVNRNREH-NENLNAEMQNL----KQKFILEQQEREKL 249
QV+ LN + + +K D+ + E N+ L A++Q L K KF + L
Sbjct: 1765 --QVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKF---KATISAL 1819
Query: 250 QQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQA 309
+ K Q++ L+QE + ++ + KL E+ +KE + E+ ++ D+ +++ E+A
Sbjct: 1820 EAKIGQLEEQLEQEAKERAAAN-KLVRRTEKKLKEIFMQVEDERR---HADQYKEQMEKA 1875
Query: 310 ERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAH 348
+KQL+ + + EE + + EL+ ++ A+
Sbjct: 1876 NARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEAN 1914
Score = 62.8 bits (151), Expect = 9e-10
Identities = 71/338 (21%), Positives = 147/338 (43%), Gaps = 22/338 (6%)
Query: 19 IQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLR 78
++DLE ++E + +++ L A +++L E + + + ++ E+ +K L+
Sbjct: 1626 LKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKES--EKKLK 1683
Query: 79 ILSLELMKLRNKRETKMRGMM-AKQEGMEMKLQVTQRSLEESQ--GKIAQLEGKLVSIEK 135
L E+++L+ + + R A+QE E+ ++T + +S + +LE ++ +E+
Sbjct: 1684 SLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEE 1743
Query: 136 EKIDEKSETEKLLEYIEEISCASDQVEKY---KLDIAQLEEN----LKEKNDEILSLKQS 188
E +E+S E L + + + D + + AQ +N L+ +N E+ + Q
Sbjct: 1744 ELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQE 1803
Query: 189 LEENIVILSKQ-VEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQERE 247
LE + K + L K LE++ E N+ + + LK+ F+ + ER
Sbjct: 1804 LEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERR 1863
Query: 248 KLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEE 307
Q + Q++ + K+L L + EE N +L++ ELD + E
Sbjct: 1864 HADQYKEQMEKANARMKQLKRQLEE-----AEEEATRANASRRKLQR---ELDDATEANE 1915
Query: 308 QAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSS 345
R V L+ + R + + ++ LE +S
Sbjct: 1916 GLSREVSTLKNRLR-RGGPISFSSSRSGRRQLHLEGAS 1952
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 117 bits (293), Expect = 3e-26
Identities = 121/546 (22%), Positives = 248/546 (45%), Gaps = 50/546 (9%)
Query: 85 MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 142
MKL K + ++ ++E MK + T+ L +++ K +LE K+V++ +EK D +
Sbjct: 834 MKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQL 893
Query: 143 ETEKLLEYIEEISCASDQVEKYKL-------DIAQLEENLKEKNDEILSLKQSLEENIVI 195
+ + + + + DQ+ K K+ ++ + E+ +E N E+ + K+ LE+
Sbjct: 894 QVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 953
Query: 196 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQ 255
L K ++DL + +EKEK H N+ +NL EM L + +E++ LQ+ Q
Sbjct: 954 LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1009
Query: 256 IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 315
LQ E++ ++L + ++++ + E+E K +D L++ + + E +K
Sbjct: 1010 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMD----LERAKRKLEGDLKL 1065
Query: 316 LEEEAKSRAEELKLLEEKLKGKEAELE--KSSAAHTQAT-LLLQEKYDSMVQSLEDVTAQ 372
+E + + L+EKLK KE E+ +S QA + LQ+K + +E++ +
Sbjct: 1066 AQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEE 1125
Query: 373 FESYKALTA---SEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDL 429
E+ +A A + DL E + E+ +AG QI + E+ +M DL
Sbjct: 1126 IEAERASRAKAEKQRSDLSRELEEISERLEEAG---GATSAQIEMNKKREAEFQKMRRDL 1182
Query: 430 QTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEE 489
+ + E + + +L Q+ + +++LE E+ + + A E
Sbjct: 1183 EEATLQHEATAATLRKKHADSVAELGEQIDNLQR-VKQKLEKEKSEMKMEIDDLASNMET 1241
Query: 490 INKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLL------ 543
++K + E++ + ++ E E+Q L+N+ A + +L Y++ L
Sbjct: 1242 VSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTL 1301
Query: 544 ------GHQNLKQKIKHVVKLKDENSQLKSEVSK-----------LRCQLAKKKQSETKL 586
G Q Q+I+ + + +E + KS ++ LR Q ++++++ +L
Sbjct: 1302 VSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAEL 1361
Query: 587 QEELNK 592
Q ++K
Sbjct: 1362 QRAMSK 1367
Score = 103 bits (258), Expect = 4e-22
Identities = 134/650 (20%), Positives = 287/650 (44%), Gaps = 76/650 (11%)
Query: 1 MTLLIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRT 60
+T R L E + I DLE L K+E +A + +L+ A L++ + +LT+
Sbjct: 940 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKE 999
Query: 61 NELLKSKFSENGNQKNLRILSLELMKLRNKRETKMR---------GMMAKQEGMEMKLQV 111
+ L + +Q+ L L E K+ + K++ G + +++ + M L+
Sbjct: 1000 KKAL-----QEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLER 1054
Query: 112 TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQL 171
+R L E K+AQ + +K+++DEK + ++ E+S ++E + QL
Sbjct: 1055 AKRKL-EGDLKLAQESTMDIENDKQQLDEKLKKKEF-----EMSGLQSKIEDEQALGMQL 1108
Query: 172 EENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAE 231
++ +KE I L++ +E +K + + L +E E+ R E +A+
Sbjct: 1109 QKKIKELQARIEELEEEIEAERASRAKAEKQRSD----LSRELEEISERLEEAGGATSAQ 1164
Query: 232 MQNLKQKFILEQQEREKLQQKELQID----SLLQQEKELSSSLHQKLCSFQ---EEMVKE 284
++ K++ Q+ R L++ LQ + +L ++ + + L +++ + Q +++ KE
Sbjct: 1165 IEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKE 1224
Query: 285 KNLFEEELKQTLDELDKLQQKEEQAERLVKQLEE---EAKSRAEELKLLEEKLKGKEAEL 341
K+ + E+ ++ + + + E++ + LE+ E K++ EE + L L + A L
Sbjct: 1225 KSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARL 1284
Query: 342 EKSSAAHTQATLLLQEKYDSMVQSL----EDVTAQFESYKALTASEIEDLKLENSSLQEK 397
+ S +++ L EK D++V L + T Q E K EI+ S+L
Sbjct: 1285 QTESGEYSRQ---LDEK-DTLVSQLSRGKQAFTQQIEELKRQLEEEIK----AKSALAHA 1336
Query: 398 AAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQ 457
+ + + ++ Q + + E R + ++ A T+ + + +++ + + +
Sbjct: 1337 LQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1396
Query: 458 LKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEE-------LYNKTKPF--- 507
L Q+ +D + +E + A E T L E+ + E L K + F
Sbjct: 1397 LAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKI 1456
Query: 508 ----QLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG--------HQNLKQKIKHV 555
+ + + E +A E + +L KI+++Y + L ++NL+Q+I +
Sbjct: 1457 LAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDL 1516
Query: 556 VKLKDENSQLKSEVSKLRCQLAKKK--------QSETKLQEELNKVLGIK 597
+ E + E+ K++ Q+ ++K ++E L+ E K+L I+
Sbjct: 1517 TEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQ 1566
Score = 96.3 bits (238), Expect = 8e-20
Identities = 130/611 (21%), Positives = 288/611 (47%), Gaps = 57/611 (9%)
Query: 4 LIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNEL 63
L+ L + + A ++I++L+ +LE+ E + +AL S ++ L ++ E
Sbjct: 1301 LVSQLSRGKQAFTQQIEELKRQLEE-EIKAKSALAHALQSSRHDCDLLREQYE------- 1352
Query: 64 LKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKI 123
+ + ++ Q+ + + E+ + R K ET + +E E K ++ QR L++++ +
Sbjct: 1353 -EEQEAKAELQRAMSKANSEVAQWRTKYETD--AIQRTEELEEAKKKLAQR-LQDAEEHV 1408
Query: 124 AQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEIL 183
+ K S+EK K ++E E L+ +E + A ++K + + ++ K+K +E
Sbjct: 1409 EAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETH 1468
Query: 184 SLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ 243
+ ++ ++ LS ++ K + +E D + + N+NL E+ +L ++
Sbjct: 1469 AELEASQKESRSLSTEL----FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGG 1524
Query: 244 QEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD-KL 302
+ +L++ + Q++ Q++ EL ++L + S + E K + + EL Q E+D K+
Sbjct: 1525 KRIHELEKIKKQVE---QEKSELQAALEEAEASLEHEEGKILRI-QLELNQVKSEVDRKI 1580
Query: 303 QQKEEQAERLVKQ-----------LEEEAKSRAEELKLLEEKLKG--KEAELEKSSAAHT 349
+K+E+ +++ + L+ E +SR + ++L ++K++G E E++ + A
Sbjct: 1581 AEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRL-KKKMEGDLNEMEIQLNHANRM 1639
Query: 350 QATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQ 409
A L Y + L+D + AL + E DLK + + ++ +A E+++
Sbjct: 1640 AAEAL--RNYRNTQAILKDTQLHLDD--ALRSQE--DLKEQLAMVERRANLLQAEIEELR 1693
Query: 410 HQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQL 469
+ TE S + + LLD + L T+ + + + TD+ +Q++ + ED ++
Sbjct: 1694 ATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDI-SQIQGEMEDIIQEA 1752
Query: 470 EDEEGRKAEKENTTAELTEEINK-------WRLLYEELYNKTKPFQLQLDAFEVEKQALL 522
+ E + + A + EE+ K + + L K Q +LD E E+ AL
Sbjct: 1753 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLD--EAEQLAL- 1809
Query: 523 NEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQS 582
++Q+ K+ +L G +QK ++V +K + +V +L Q + +++
Sbjct: 1810 ---KGGKKQIQKLEARVRELEGEVESEQK-RNVEAVKGLRKH-ERKVKELTYQTEEDRKN 1864
Query: 583 ETKLQEELNKV 593
+LQ+ ++K+
Sbjct: 1865 ILRLQDLVDKL 1875
Score = 95.9 bits (237), Expect = 1e-19
Identities = 133/629 (21%), Positives = 275/629 (43%), Gaps = 86/629 (13%)
Query: 22 LETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILS 81
L+ ++++++AR+ E + A+ A EKQ +L+R E + + E G + +I
Sbjct: 1108 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI-- 1165
Query: 82 LELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG-KIAQLEGKLVSIEKEKIDE 140
++ KRE + + M E ++ + T +L + +A+L ++ ++++ K
Sbjct: 1166 ----EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKL 1221
Query: 141 KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQV 200
+ E ++ I++++ + V K K LE+ + D++ +K EE + +
Sbjct: 1222 EKEKSEMKMEIDDLASNMETVSKAK---GNLEKMCRALEDQLSEIKTKEEEQ----QRLI 1274
Query: 201 EDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLL 260
DL + L+ E ++ +R + + L +++ KQ F + +E ++ ++E++ S L
Sbjct: 1275 NDLTAQRARLQTESGEY-SRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSAL 1333
Query: 261 QQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEA 320
L SS H C E +E+ + EL++ + + + E A+ K E +A
Sbjct: 1334 AHA--LQSSRHD--CDLLREQYEEEQEAKAELQRAMSKANS-----EVAQWRTKY-ETDA 1383
Query: 321 KSRAEEL----KLLEEKLKGKEAELE----KSSAAHTQATLLLQEKYDSMV--------- 363
R EEL K L ++L+ E +E K ++ L E D M+
Sbjct: 1384 IQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAAC 1443
Query: 364 -------QSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 416
++ + + A+++ T +E+E + E+ SL + K E+ Q+ +
Sbjct: 1444 AALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLK 1503
Query: 417 SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGR- 475
N+ + + DL + A I E+ +++ +++L+ E+ LE EEG+
Sbjct: 1504 RENKNLQQEISDLTEQIAEGGKRIHELE-KIKKQVEQEKSELQAALEEAEASLEHEEGKI 1562
Query: 476 ----------KAEKENTTAELTEEINKWR------------LLYEELYNKTKPFQLQL-- 511
K+E + AE EEI++ + L E+ ++ +L+
Sbjct: 1563 LRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKM 1622
Query: 512 --DAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQ-NLKQKIKHVVKLKDENSQ---- 564
D E+E Q L + + A E L R++ A L Q +L ++ LK++ +
Sbjct: 1623 EGDLNEMEIQ-LNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERR 1681
Query: 565 ---LKSEVSKLRCQLAKKKQSETKLQEEL 590
L++E+ +LR L + ++S ++EL
Sbjct: 1682 ANLLQAEIEELRATLEQTERSRKIAEQEL 1710
Score = 65.5 bits (158), Expect = 1e-10
Identities = 78/349 (22%), Positives = 156/349 (44%), Gaps = 42/349 (12%)
Query: 9 LQERGAQDRRIQDLETELEKMEARLN-------AALREKTSLSANNATLEKQLIELTRTN 61
++ R R + +E +L +ME +LN ALR + A + L + R+
Sbjct: 1609 IRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQ 1668
Query: 62 ELLKSKFSENGNQKNLRILSLELMKLRNKRE-TKMRGMMAKQEGMEMKLQV--------- 111
E LK + + + NL L E+ +LR E T+ +A+QE ++ +V
Sbjct: 1669 EDLKEQLAMVERRANL--LQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1726
Query: 112 ---TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDI 168
T++ LE I+Q++G++ I +E ++ EK + I + + +++++K +
Sbjct: 1727 LINTKKKLETD---ISQIQGEMEDIIQEA---RNAEEKAKKAITDAAMMAEELKKEQDTS 1780
Query: 169 AQLEENLKEKNDEILSLKQSLEENIVIL----SKQVEDLNVKCQLLEKEKEDHVNRNREH 224
A LE K + L+ L+E + KQ++ L + + LE E E RN E
Sbjct: 1781 AHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEA 1840
Query: 225 NENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKE 284
+ L + +K+ +++R+ + + + +D L + K EE ++
Sbjct: 1841 VKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQ--------AEEAEEQ 1892
Query: 285 KNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 333
N+ + ++ EL++ +++ + AE V +L KSR K++ E+
Sbjct: 1893 SNVNLSKFRRIQHELEEAEERADIAESQVNKL--RVKSREVHTKIISEE 1939
Score = 57.0 bits (136), Expect = 5e-08
Identities = 91/435 (20%), Positives = 182/435 (41%), Gaps = 64/435 (14%)
Query: 9 LQERGAQDRRIQDLETELEKMEARLNAALRE-KTSLSANNATLEKQLIELTRTNELLKSK 67
+ E G + ++ ++ ++E+ ++ L AAL E + SL + + +EL + + K
Sbjct: 1520 IAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRK 1579
Query: 68 FSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLE 127
+E + ++ MK + R E M+ L RS ++ ++E
Sbjct: 1580 IAEKDEE-------IDQMKRNHIRIV---------ESMQSTLDAEIRSRNDAIRLKKKME 1623
Query: 128 GKLVSIE----------KEKIDEKSETEKLLEYIE-EISCASDQVEKYKLDIAQLEENLK 176
G L +E E + T+ +L+ + + A E K +A +E
Sbjct: 1624 GDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRAN 1683
Query: 177 EKNDEILSLKQSLEE---NIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLN---A 230
EI L+ +LE+ + I +++ D + + QLL + +N ++ +++
Sbjct: 1684 LLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQG 1743
Query: 231 EMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEE 290
EM+++ Q+ +++ +K + L++E++ S+ L E M K +
Sbjct: 1744 EMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHL--------ERMKKNLEQTVK 1795
Query: 291 ELKQTLDELDKL---------QQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAEL 341
+L+ LDE ++L Q+ E + L ++E E K E +K L K + K EL
Sbjct: 1796 DLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGL-RKHERKVKEL 1854
Query: 342 EKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS----LQEK 397
+ + L LQ+ D + A+ +SYK A E E+ N S +Q +
Sbjct: 1855 TYQTEEDRKNILRLQDLVDKL-------QAKVKSYKR-QAEEAEEQSNVNLSKFRRIQHE 1906
Query: 398 AAKAGKNAEDVQHQI 412
+A + A+ + Q+
Sbjct: 1907 LEEAEERADIAESQV 1921
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 117 bits (292), Expect = 4e-26
Identities = 133/551 (24%), Positives = 259/551 (47%), Gaps = 60/551 (10%)
Query: 85 MKLRNKRETKMRGMMAKQEGMEMKLQVTQ--RSLEESQGKIAQLEGKLVSIEKEKIDEKS 142
MKL K + ++ ++E MK + T+ +LE+S+ + +LE K+VS+ +EK D +
Sbjct: 830 MKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQL 889
Query: 143 ETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND----------EILSLKQSLEEN 192
+ + + + + DQ+ K K+ QLE +KE N+ E+ + K+ LE+
Sbjct: 890 QVQAEQDNLADAEERCDQLIKNKI---QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE 946
Query: 193 IVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK 252
L + ++DL + +EKEK N+ + NL EM L + +E++ LQ+
Sbjct: 947 CSELKRDIDDLELTLAKVEKEKHATENKVK----NLTEEMAGLDEIIAKLTKEKKALQEA 1002
Query: 253 ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 312
Q LQ E++ ++L + ++++ + E+E K +D L++ + + E
Sbjct: 1003 HQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMD----LERAKRKLEGD 1058
Query: 313 VKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLL---LQEKYDSMVQSLEDV 369
+K +E + + L+E+LK K+ EL +A L LQ+K + +E++
Sbjct: 1059 LKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEEL 1118
Query: 370 TAQFESYKALTASEIE----DLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRM 425
+ E+ + A ++E DL E + E+ +AG A V QI + E+ +M
Sbjct: 1119 EEELEAERTARA-KVEKLRSDLSRELEEISERLEEAG-GATSV--QIEMNKKREAEFQKM 1174
Query: 426 LLDLQ--------TKSALKETEIKEITVSFLQKITDLQ---NQLKQQEEDFRKQLEDEEG 474
DL+ T +AL++ + ++I +LQ +L++++ +F+ +L+D
Sbjct: 1175 RRDLEEATLQHEATAAALRKKHADSV-AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTS 1233
Query: 475 R-------KAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQAL---LNE 524
KA E L +++N+ R EE Q + E L L+E
Sbjct: 1234 NMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDE 1293
Query: 525 HGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKK-QSE 583
A QL + + +Y + L ++LK++++ VK K+ + + ++ C L +++ + E
Sbjct: 1294 KEALISQLTRGKLTYTQQL--EDLKRQLEEEVKAKNALAH-ALQSARHDCDLLREQYEEE 1350
Query: 584 TKLQEELNKVL 594
T+ + EL +VL
Sbjct: 1351 TEAKAELQRVL 1361
Score = 100 bits (248), Expect = 5e-21
Identities = 130/622 (20%), Positives = 274/622 (44%), Gaps = 57/622 (9%)
Query: 1 MTLLIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRT 60
+T R L E R I DLE L K+E +A + +L+ A L++ + +LT+
Sbjct: 936 LTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE 995
Query: 61 NELLKSKFSE-----NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRS 115
+ L+ + + + L+ +KL + + + G + +++ + M L+ +R
Sbjct: 996 KKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVD-DLEGSLEQEKKVRMDLERAKRK 1054
Query: 116 LEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENL 175
LE G + + ++ +E D++ E+L + E++ + ++E + +QL++ L
Sbjct: 1055 LE---GDLKLTQESIMDLEN---DKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKL 1108
Query: 176 KEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNL 235
KE I L++ LE +K VE L L +E E+ R E + +++
Sbjct: 1109 KELQARIEELEEELEAERTARAK-VEKLRSD---LSRELEEISERLEEAGGATSVQIEMN 1164
Query: 236 KQKFILEQQEREKLQQKELQID----SLLQQEKELSSSLHQKLCSFQ---EEMVKEKNLF 288
K++ Q+ R L++ LQ + +L ++ + + L +++ + Q +++ KEK+ F
Sbjct: 1165 KKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEF 1224
Query: 289 EEELKQTLDELDKLQQKEEQAERLVKQLEE---EAKSRAEELKLLEEKLKGKEAELEKSS 345
+ EL ++++ + + E++ + LE+ E +S+AEE + L + A+L+ +
Sbjct: 1225 KLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTEN 1284
Query: 346 AAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLE-------NSSLQEKA 398
+ + L EK E + +Q K ++EDLK + ++L
Sbjct: 1285 G---ELSRQLDEK--------EALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHAL 1333
Query: 399 AKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQL 458
A + + ++ Q + E R+L ++ A T+ + + +++ + + +L
Sbjct: 1334 QSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKL 1393
Query: 459 KQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEE-------LYNKTKPFQLQL 511
Q+ ++ + +E + + E T L EI + E L K + F L
Sbjct: 1394 AQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKIL 1453
Query: 512 DAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSK 571
++ + + +E ++Q++ + KL ++ ++H+ K EN L+ E+S
Sbjct: 1454 AEWKQKYEESQSELESSQKEARSLSTELFKL--KNAYEESLEHLETFKRENKNLQEEISD 1511
Query: 572 LRCQLAKKKQSETKLQEELNKV 593
L QL S K EL KV
Sbjct: 1512 LTEQLG----SSGKTIHELEKV 1529
Score = 100 bits (248), Expect = 5e-21
Identities = 144/647 (22%), Positives = 269/647 (41%), Gaps = 77/647 (11%)
Query: 4 LIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN-E 62
+I L +E+ A Q +L+ E ++N + K L LE L + + +
Sbjct: 988 IIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMD 1047
Query: 63 LLKSKFSENGNQKNLRILSLELMKLRN----------KRETKMRGMMAKQEGMEMKLQVT 112
L ++K G+ L++ +M L N K++ ++ + A+ E +
Sbjct: 1048 LERAKRKLEGD---LKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQL 1104
Query: 113 QRSLEESQGKIAQLEGKL-------VSIEKEKIDEKSETEKLLEYIEEISCASD-QVEKY 164
Q+ L+E Q +I +LE +L +EK + D E E++ E +EE A+ Q+E
Sbjct: 1105 QKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMN 1164
Query: 165 KLDIAQLEENLKEKNDEIL-------SLKQSLEENIVILSKQVEDLNVKCQLLEKEKE-- 215
K A+ ++ ++ + L +L++ +++ L +Q+++L Q LEKEK
Sbjct: 1165 KKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEF 1224
Query: 216 ----DHVNRNREHNENLNAEMQNLKQKFILEQQ--------------------EREKLQQ 251
D V N E A ++ + + LE Q +R KLQ
Sbjct: 1225 KLELDDVTSNMEQIIKAKANLEKMCRT--LEDQMNEHRSKAEETQRSVNDLTSQRAKLQT 1282
Query: 252 KELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAER 311
+ ++ L +++ L S L + ++ +++ K EEE+K LQ +
Sbjct: 1283 ENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDL 1342
Query: 312 LVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTA 371
L +Q EEE +++AE ++L + K Q T L+E + Q L++
Sbjct: 1343 LREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEE 1402
Query: 372 QFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQT 431
E+ A +S L+ LQ + + E A + + + ++L + +
Sbjct: 1403 AVEAVNAKCSS----LEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ 1458
Query: 432 KSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAE---LTE 488
K ++E++ S ++ L +L + + + + LE E K E +N E LTE
Sbjct: 1459 KYEESQSELE----SSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTE 1514
Query: 489 EINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE-QLNKIRDSYAKLLGHQN 547
++ EL K QL+A ++E Q+ L E A+ E + KI + L
Sbjct: 1515 QLGSSGKTIHELEKVRK----QLEAEKMELQSALEEAEASLEHEEGKILRAQ---LEFNQ 1567
Query: 548 LKQKIKHVVKLKDEN-SQLKSEVSKLRCQLAKKKQSETKLQEELNKV 593
+K +I+ + KDE Q K ++ L +ET+ + E +V
Sbjct: 1568 IKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRV 1614
Score = 83.6 bits (205), Expect = 5e-16
Identities = 123/595 (20%), Positives = 249/595 (41%), Gaps = 76/595 (12%)
Query: 17 RRIQDLETELEKMEARLNAALREKTSL--------------SANNATLEKQLIELTRTNE 62
+R+Q+ E +E + A+ ++ + K L +A A L+K+ +
Sbjct: 1395 QRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA 1454
Query: 63 LLKSKFSEN-----GNQKNLRILSLELMKLRNKRETKMRGMMA-KQEGMEMKLQVTQRSL 116
K K+ E+ +QK R LS EL KL+N E + + K+E ++ +++ L
Sbjct: 1455 EWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISD--L 1512
Query: 117 EESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLK 176
E G + +L + K+ EK E + LE E AS + E+ K+ AQLE N
Sbjct: 1513 TEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAE----ASLEHEEGKILRAQLEFN-- 1566
Query: 177 EKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLK 236
+K +E + K + +E+ K +H+ +L+AE ++
Sbjct: 1567 -------QIKAEIERKLA----------EKDEEMEQAKRNHLRVVDSLQTSLDAETRSRN 1609
Query: 237 QKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL 296
+ ++++ L + E+Q+ + E QK + ++K+ + ++ +
Sbjct: 1610 EALRVKKKMEGDLNEMEIQLSHANRMAAEA-----QKQVKSLQSLLKDTQIQLDDAVRAN 1664
Query: 297 DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQ 356
D+L KE A +V++ ++ EEL+ + E+ + E+ ++ LL
Sbjct: 1665 DDL-----KENIA--IVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLH 1717
Query: 357 EKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 416
+ S++ + + A + +E+E+ E + +EKA KA +A + ++ +
Sbjct: 1718 SQNTSLINQKKKMDADLSQLQ----TEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQ 1773
Query: 417 SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRK 476
++ RM +++ + + E L+ +L+ + + +LE E+ R
Sbjct: 1774 DTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRN 1833
Query: 477 AEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIR 536
AE + I + EE Q +D +++ +A + A+EQ N
Sbjct: 1834 AESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNL 1893
Query: 537 DSYAKLLGHQNLKQKIKHVVKLKDENSQL-KSEVSKLRCQLAKKKQSETK-LQEE 589
+ +K++H + +E + + +S+V+KLR AK + TK L EE
Sbjct: 1894 SKF----------RKVQHELDEAEERADIAESQVNKLR---AKSRDIGTKGLNEE 1935
Score = 63.9 bits (154), Expect = 4e-10
Identities = 83/426 (19%), Positives = 185/426 (43%), Gaps = 68/426 (15%)
Query: 8 LLQERGAQDRRIQDLETELEKMEAR---LNAALRE-KTSLSANNATLEKQLIELTRTNEL 63
L ++ G+ + I +LE +++EA L +AL E + SL + + +E +
Sbjct: 1512 LTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAE 1571
Query: 64 LKSKFSENGNQ----KNLRILSLELMKLRNKRETKMRG----MMAKQEG----MEMKLQV 111
++ K +E + K + ++ ++ ET+ R + K EG ME++L
Sbjct: 1572 IERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSH 1631
Query: 112 TQRSLEESQGKIAQLEGKLVSIEKEKIDE---------------------KSETEKLLEY 150
R E+Q ++ L+ L + + D ++E E+L
Sbjct: 1632 ANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAV 1691
Query: 151 IEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLL 210
+E+ + E+ ++ ++ + L +N +++ K+ ++ ++ L +VE+ +C+
Sbjct: 1692 VEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNA 1751
Query: 211 EKEKE----------DHVNRNREHNENLNAEMQNLKQ-----KFILEQQEREKLQQKELQ 255
E++ + + + + ++ + +L +N++Q + L++ E+ L+ + Q
Sbjct: 1752 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQ 1811
Query: 256 IDSLLQQEKELSSSLHQ---------KLCSFQEEMVKEKNLFEEELKQTL----DELDKL 302
+ L + +EL + L K E +KE EE ++ L D +DKL
Sbjct: 1812 LQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKL 1871
Query: 303 QQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSM 362
Q K + +R ++ EE+A + + + ++ +L EAE E++ A +Q L + D
Sbjct: 1872 QLKVKAYKRQAEEAEEQANTNLSKFRKVQHEL--DEAE-ERADIAESQVNKLRAKSRDIG 1928
Query: 363 VQSLED 368
+ L +
Sbjct: 1929 TKGLNE 1934
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 117 bits (292), Expect = 4e-26
Identities = 142/609 (23%), Positives = 284/609 (46%), Gaps = 71/609 (11%)
Query: 25 ELEKMEARLNAALREK-TSLSANNATLEK----QLIELTRTNELLKSKFSENGNQKNLRI 79
E+E + A+L ++EK SL A + L+K L+E+ T L+ + +++
Sbjct: 645 EMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQ--------EAEIKV 696
Query: 80 LSLELMKLRNKRETKMRGMMAKQ----EGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEK 135
LE+++ + +TK+ Q E + L +++ E + ++ +L +L + EK
Sbjct: 697 KELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEK 756
Query: 136 E----KIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEE 191
+ +I++ +E+ K S + +++ +L + L+ENL E + +K++LE+
Sbjct: 757 QIKHLEIEKNAESSKA-------SSITRELQGRELKLTNLQENLSE----VSQVKETLEK 805
Query: 192 NIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLN---AEMQNLKQ-------KFIL 241
+ IL ++ + + + +++ ++ VN+ + E N ++++ L++ KF
Sbjct: 806 ELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE 865
Query: 242 EQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEM-VKEKNLFEEELKQT-LDEL 299
+ + E+L + + ++++ + + ++S +L +E+ +KE+++ E +LK T +E
Sbjct: 866 KDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN 925
Query: 300 DKLQQK--EEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKS-------SAAHTQ 350
QK E+ + + +E AK EE K LE KL E ++E S A + +
Sbjct: 926 ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 985
Query: 351 ATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKA--AKAGKNAEDV 408
AT + K++ ++Q+L+ E E L E L+++A AKA + AED
Sbjct: 986 ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1045
Query: 409 QHQILATESSNQEYVRMLLDLQTKSA--------LKETEIKEITVSFLQKITDLQNQLKQ 460
+ E + L D + +A LKE +K V L K +L Q
Sbjct: 1046 MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLK--NVEELNKSKELLTVENQ 1103
Query: 461 QEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQA 520
+ E+FRK++E + A+K + L EE K L EEL +++ E E+
Sbjct: 1104 KMEEFRKEIETLKQAAAQKSQQLSALQEENVK---LAEEL-GRSRDEVTSHQKLEEERSV 1159
Query: 521 LLNEHGAAQEQLNK-IRDSYAKLLGHQNLKQKIKHVVKLKD-ENSQLKSEVSKLRCQLAK 578
L N+ +++ +K I+D+ + Q ++ KD E +L++EV+ LR + A
Sbjct: 1160 LNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENAS 1219
Query: 579 KKQSETKLQ 587
K + +Q
Sbjct: 1220 AKSLHSVVQ 1228
Score = 92.8 bits (229), Expect = 9e-19
Identities = 130/586 (22%), Positives = 231/586 (39%), Gaps = 99/586 (16%)
Query: 5 IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL 64
I+ L E+ A+ + + EL+ E +L + +S TLEK+L ++L
Sbjct: 758 IKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKEL-------QIL 810
Query: 65 KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA 124
K KF+E S E + ++ + + + K+E M LE+ + +A
Sbjct: 811 KEKFAE---------ASEEAVSVQRSMQETVNKLHQKEEQFNM----LSSDLEKLRENLA 857
Query: 125 QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 184
+E K ++ + EKL I EI S +L E LKE++ E L
Sbjct: 858 DMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGD-NSSQLTKMNDELRLKERDVEELQ 916
Query: 185 LK-QSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ 243
LK EN L K +ED+ VK E+ +++ ++ E + L ++ +L++K
Sbjct: 917 LKLTKANENASFLQKSIEDMTVKA---EQSQQEAAKKHEEEKKELERKLSDLEKKMETSH 973
Query: 244 QEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQ 303
+ ++L+ + + S E K + + + K LD DKL+
Sbjct: 974 NQCQELKARYERATS--------------------ETKTKHEEILQNLQKTLLDTEDKLK 1013
Query: 304 QKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMV 363
E+ L+++LEE K + +K+ AA T + +
Sbjct: 1014 GAREENSGLLQELEELRK------------------QADKAKAAQTA---------EDAM 1046
Query: 364 QSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYV 423
Q +E +T + K T + +ED K N+ LQ + +N N E +
Sbjct: 1047 QIMEQMTKE----KTETLASLEDTKQTNAKLQNELDTLKEN-----------NLKNVEEL 1091
Query: 424 RMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTT 483
+L T K E ++ + Q QL +E+ +L +E GR ++ +
Sbjct: 1092 NKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEE-NVKLAEELGRSRDEVTSH 1150
Query: 484 AELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQ-------ALLNEHGAAQEQLNKIR 536
+L EE + E+ + F D + Q ALL E A +L K+R
Sbjct: 1151 QKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDA---ELEKLR 1207
Query: 537 DSYAKLLGHQNLKQKIKHVVK-LKDENSQLKSEVSKLRCQLAKKKQ 581
+ L G + + VV+ L+ + +L+ +V L QL + K+
Sbjct: 1208 NEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKR 1253
Score = 90.9 bits (224), Expect = 3e-18
Identities = 136/622 (21%), Positives = 263/622 (42%), Gaps = 61/622 (9%)
Query: 12 RGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIE----LTRTNELLKSK 67
R D+ + +LE +++++ + AA REK L N EK+ +E + K
Sbjct: 396 RDGHDQHVLELEAKMDQLRTMVEAADREKVEL-LNQLEEEKRKVEDLQFRVEEESITKGD 454
Query: 68 FSENGNQKNLRILSLE---LMKLRNKRETKMRGMMAKQEG-MEMKLQVTQR--SLEESQG 121
+ RI+ LE ++++ E + R K G ++M L + Q SL+E
Sbjct: 455 LEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLE 514
Query: 122 KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDI-AQLEENLKEKND 180
+ ++ KE + ET + + I+ + A++++ K + ++LE KE +D
Sbjct: 515 VTRTDHQREITSLKEHFGAREETHQ--KEIKALYTATEKLSKENESLKSKLEHANKENSD 572
Query: 181 EILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFI 240
I K LE I + +E+L V + + E + + Q+ +
Sbjct: 573 VIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQ 632
Query: 241 LEQQEREKLQQKELQI--DSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDE 298
+Q KE++ L++ KE +SL + + ++ K ++ E++ TL++
Sbjct: 633 NQQDSERAAHAKEMEALRAKLMKVIKEKENSLE----AIRSKLDKAEDQHLVEMEDTLNK 688
Query: 299 LDKLQQKEEQAERLVKQLEEEAK---SRAEELKLLEEKLKGKEAELEKSSAAHTQATLLL 355
L + + K ++ E L + E+ K + +LK EEKL +A + SS ++ L
Sbjct: 689 LQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLR 748
Query: 356 Q--EKYDSMVQSLEDVTAQFESYKALTAS-EIEDLKLENSSLQEKAAKAGKNAEDVQHQI 412
Q E + ++ LE + ES KA + + E++ +L+ ++LQE ++ + E ++ ++
Sbjct: 749 QQLEAAEKQIKHLE-IEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKEL 807
Query: 413 LATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDE 472
+ K E E VS + + + N+L Q+EE F D
Sbjct: 808 QILKE------------------KFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDL 849
Query: 473 EGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQL 532
E + + A+ E+ + EE K K +L+ D E+ K + G QL
Sbjct: 850 EKLRENLADMEAKFREKDER-----EEQLIKAKE-KLENDIAEIMKMS-----GDNSSQL 898
Query: 533 NKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNK 592
K+ D L +++++ + K + S L+ + + + + +Q K EE K
Sbjct: 899 TKMNDELR--LKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKK 956
Query: 593 VLGIKHFDPSKAF---HHESKE 611
L K D K H++ +E
Sbjct: 957 ELERKLSDLEKKMETSHNQCQE 978
Score = 90.5 bits (223), Expect = 4e-18
Identities = 147/666 (22%), Positives = 286/666 (42%), Gaps = 154/666 (23%)
Query: 19 IQDLETELEKMEARLNAALREKTSLS----ANNATLEKQLI-------ELTRTNELLKSK 67
+Q++ + EK+E RE TSL A T +K++ +L++ NE LKSK
Sbjct: 503 LQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSK 562
Query: 68 FSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLE 127
E+ N++N +++L KL E + Q+++EE +
Sbjct: 563 L-EHANKENSDVIALWKSKL------------------ETAIASHQQAMEELK------- 596
Query: 128 GKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQ 187
VS K E +E +L Q+EK +LD ENL+ + D +
Sbjct: 597 ---VSFSKGLGTETAEFAEL----------KTQIEKMRLDYQHEIENLQNQQDSERAAH- 642
Query: 188 SLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQER- 246
+K++E L K + KEKE+ + E + +++ + + ++E ++
Sbjct: 643 ---------AKEMEALRAKLMKVIKEKENSL-------EAIRSKLDKAEDQHLVEMEDTL 686
Query: 247 EKLQQKELQIDSLL-------QQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDEL 299
KLQ+ E+++ L +Q K + + Q + EE + + + + + E+
Sbjct: 687 NKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKAT--EEKLLDLDALRKASSEGKSEM 744
Query: 300 DKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEK-----SSAAHTQATL- 353
KL+Q+ E AE+ +K LE E + + + + +L+G+E +L S + + TL
Sbjct: 745 KKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLE 804
Query: 354 ----LLQEKYD-----------SMVQSLEDVTAQFESYKALTASEIEDLK---------- 388
+L+EK+ SM +++ + + E + L+ S++E L+
Sbjct: 805 KELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLS-SDLEKLRENLADMEAKF 863
Query: 389 LENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITV--- 445
E +E+ KA + E+ +I+ N + + D + LKE +++E+ +
Sbjct: 864 REKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND---ELRLKERDVEELQLKLT 920
Query: 446 ------SFLQK-ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEIN------- 491
SFLQK I D+ + +Q +++ K+ E+E K E E ++L +++
Sbjct: 921 KANENASFLQKSIEDMTVKAEQSQQEAAKKHEEE---KKELERKLSDLEKKMETSHNQCQ 977
Query: 492 KWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQK 551
+ + YE ++TK ++ + ++ LL+ +++L R+ + LL Q L++
Sbjct: 978 ELKARYERATSETKTKHEEI--LQNLQKTLLD----TEDKLKGAREENSGLL--QELEEL 1029
Query: 552 IKHVVKLKDENS---------QLKSEVSKLRCQLAKKKQSETKLQEEL-----NKVLGIK 597
K K K + Q+ E ++ L KQ+ KLQ EL N + ++
Sbjct: 1030 RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE 1089
Query: 598 HFDPSK 603
+ SK
Sbjct: 1090 ELNKSK 1095
Score = 64.3 bits (155), Expect = 3e-10
Identities = 98/422 (23%), Positives = 191/422 (45%), Gaps = 74/422 (17%)
Query: 246 REKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDEL----DK 301
+E L++K+ I+ LL E++L + K S E+ +E L + Q + EL D+
Sbjct: 354 QEALKEKQQHIEQLLA-ERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQ 412
Query: 302 LQQKEEQAER----LVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQE 357
L+ E A+R L+ QLEEE K + E+L+ E+ + +LE ++ + + L++
Sbjct: 413 LRTMVEAADREKVELLNQLEEE-KRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEK 471
Query: 358 KYDSMVQSLEDVTAQFESYKALTASEIE---DLKLENSSLQEK----------------- 397
VQ + ++ + ES K A +++ L E SSLQEK
Sbjct: 472 DLALRVQEVAELRRRLESNK--PAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKE 529
Query: 398 --AAKAGKNAEDVQHQILATE--SSNQEYVRMLLD----------------LQTKSALKE 437
A+ + ++++ ATE S E ++ L+ L+T A +
Sbjct: 530 HFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQ 589
Query: 438 TEIKEITVSFLQ-------KITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEI 490
++E+ VSF + + +L+ Q+++ D++ ++E+ + ++ + A+ E +
Sbjct: 590 QAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEAL 649
Query: 491 N-KWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLK 549
K + +E N + + +LD + E Q L+ ++ LNK++++ K+ + L+
Sbjct: 650 RAKLMKVIKEKENSLEAIRSKLD--KAEDQHLVE----MEDTLNKLQEAEIKVKELEVLQ 703
Query: 550 QKIKHVVKLKDE-NSQLKS------EVSKLRCQLAKKKQSETKLQEELNKV-LGIKHFDP 601
K K+ D SQLK+ ++ LR ++ K KL+++L IKH +
Sbjct: 704 AKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEI 763
Query: 602 SK 603
K
Sbjct: 764 EK 765
Score = 35.4 bits (80), Expect = 0.16
Identities = 61/285 (21%), Positives = 118/285 (41%), Gaps = 66/285 (23%)
Query: 399 AKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETE---------IKEITVSFLQ 449
AKA NA +++AT S++ + L + S++ + + E + + +
Sbjct: 289 AKAKANAV---RRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYAR 345
Query: 450 KI---TDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYE-------E 499
KI T LQ LK++++ + L + + +AE T+ + E + L + E
Sbjct: 346 KISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLE 405
Query: 500 LYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIK------ 553
L K + ++A + EK LLN+ +E+ K+ D ++ K ++
Sbjct: 406 LEAKMDQLRTMVEAADREKVELLNQ---LEEEKRKVEDLQFRVEEESITKGDLEVATVSE 462
Query: 554 --HVVKLKDENSQLKSEVSKLRCQLAKKK------------QSETKLQEEL--------N 591
+++L+ + + EV++LR +L K Q + LQE+L
Sbjct: 463 KSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQR 522
Query: 592 KVLGIK-HFDPSKAFHHE------------SKENFALKTPLKEGN 623
++ +K HF + H + SKEN +LK+ L+ N
Sbjct: 523 EITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHAN 567
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 117 bits (292), Expect = 4e-26
Identities = 142/609 (23%), Positives = 284/609 (46%), Gaps = 71/609 (11%)
Query: 25 ELEKMEARLNAALREK-TSLSANNATLEK----QLIELTRTNELLKSKFSENGNQKNLRI 79
E+E + A+L ++EK SL A + L+K L+E+ T L+ + +++
Sbjct: 680 EMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQ--------EAEIKV 731
Query: 80 LSLELMKLRNKRETKMRGMMAKQ----EGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEK 135
LE+++ + +TK+ Q E + L +++ E + ++ +L +L + EK
Sbjct: 732 KELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEK 791
Query: 136 E----KIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEE 191
+ +I++ +E+ K S + +++ +L + L+ENL E + +K++LE+
Sbjct: 792 QIKHLEIEKNAESSKA-------SSITRELQGRELKLTNLQENLSE----VSQVKETLEK 840
Query: 192 NIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLN---AEMQNLKQ-------KFIL 241
+ IL ++ + + + +++ ++ VN+ + E N ++++ L++ KF
Sbjct: 841 ELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE 900
Query: 242 EQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEM-VKEKNLFEEELKQT-LDEL 299
+ + E+L + + ++++ + + ++S +L +E+ +KE+++ E +LK T +E
Sbjct: 901 KDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN 960
Query: 300 DKLQQK--EEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKS-------SAAHTQ 350
QK E+ + + +E AK EE K LE KL E ++E S A + +
Sbjct: 961 ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 1020
Query: 351 ATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKA--AKAGKNAEDV 408
AT + K++ ++Q+L+ E E L E L+++A AKA + AED
Sbjct: 1021 ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1080
Query: 409 QHQILATESSNQEYVRMLLDLQTKSA--------LKETEIKEITVSFLQKITDLQNQLKQ 460
+ E + L D + +A LKE +K V L K +L Q
Sbjct: 1081 MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLK--NVEELNKSKELLTVENQ 1138
Query: 461 QEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQA 520
+ E+FRK++E + A+K + L EE K L EEL +++ E E+
Sbjct: 1139 KMEEFRKEIETLKQAAAQKSQQLSALQEENVK---LAEEL-GRSRDEVTSHQKLEEERSV 1194
Query: 521 LLNEHGAAQEQLNK-IRDSYAKLLGHQNLKQKIKHVVKLKD-ENSQLKSEVSKLRCQLAK 578
L N+ +++ +K I+D+ + Q ++ KD E +L++EV+ LR + A
Sbjct: 1195 LNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENAS 1254
Query: 579 KKQSETKLQ 587
K + +Q
Sbjct: 1255 AKSLHSVVQ 1263
Score = 92.8 bits (229), Expect = 9e-19
Identities = 130/586 (22%), Positives = 231/586 (39%), Gaps = 99/586 (16%)
Query: 5 IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL 64
I+ L E+ A+ + + EL+ E +L + +S TLEK+L ++L
Sbjct: 793 IKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKEL-------QIL 845
Query: 65 KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA 124
K KF+E S E + ++ + + + K+E M LE+ + +A
Sbjct: 846 KEKFAE---------ASEEAVSVQRSMQETVNKLHQKEEQFNM----LSSDLEKLRENLA 892
Query: 125 QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 184
+E K ++ + EKL I EI S +L E LKE++ E L
Sbjct: 893 DMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGD-NSSQLTKMNDELRLKERDVEELQ 951
Query: 185 LK-QSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ 243
LK EN L K +ED+ VK E+ +++ ++ E + L ++ +L++K
Sbjct: 952 LKLTKANENASFLQKSIEDMTVKA---EQSQQEAAKKHEEEKKELERKLSDLEKKMETSH 1008
Query: 244 QEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQ 303
+ ++L+ + + S E K + + + K LD DKL+
Sbjct: 1009 NQCQELKARYERATS--------------------ETKTKHEEILQNLQKTLLDTEDKLK 1048
Query: 304 QKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMV 363
E+ L+++LEE K + +K+ AA T + +
Sbjct: 1049 GAREENSGLLQELEELRK------------------QADKAKAAQTA---------EDAM 1081
Query: 364 QSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYV 423
Q +E +T + K T + +ED K N+ LQ + +N N E +
Sbjct: 1082 QIMEQMTKE----KTETLASLEDTKQTNAKLQNELDTLKEN-----------NLKNVEEL 1126
Query: 424 RMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTT 483
+L T K E ++ + Q QL +E+ +L +E GR ++ +
Sbjct: 1127 NKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEE-NVKLAEELGRSRDEVTSH 1185
Query: 484 AELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQ-------ALLNEHGAAQEQLNKIR 536
+L EE + E+ + F D + Q ALL E A +L K+R
Sbjct: 1186 QKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDA---ELEKLR 1242
Query: 537 DSYAKLLGHQNLKQKIKHVVK-LKDENSQLKSEVSKLRCQLAKKKQ 581
+ L G + + VV+ L+ + +L+ +V L QL + K+
Sbjct: 1243 NEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKR 1288
Score = 91.7 bits (226), Expect = 2e-18
Identities = 141/648 (21%), Positives = 267/648 (41%), Gaps = 78/648 (12%)
Query: 12 RGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN 71
R D+ + +LE +++++ + AA REK L QL E R E L+ + E
Sbjct: 396 RDGHDQHVLELEAKMDQLRTMVEAADREKVELL-------NQLEEEKRKVEDLQFRVEEE 448
Query: 72 GNQKNLRILSLELM-KLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKL 130
K LE KL + R ++ + ++ KL QR LE+++ + ++
Sbjct: 449 SITKG----DLETQTKLEHARIKELEQSLLFEKTKADKL---QRELEDTRVATVSEKSRI 501
Query: 131 VSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL--DIAQLEENLK----EKNDEILS 184
+ +EK+ E +L +E A D L +I+ L+E L+ + EI S
Sbjct: 502 MELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITS 561
Query: 185 LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNR----NREHNENLNAEMQNLKQKFI 240
LK+ K+++ L + L KE E ++ N+E+++ + L+
Sbjct: 562 LKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIA 621
Query: 241 LEQQEREKLQQK-ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDEL 299
QQ E+L+ + + + EL + + + +Q E+ +N + E E+
Sbjct: 622 SHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEM 681
Query: 300 DKL--------QQKEEQAERLVKQLEEEAKSRAEEL-----KLLEEKLKGKEAELEKSSA 346
+ L ++KE E + +L++ E+ KL E ++K KE E+ ++
Sbjct: 682 EALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKC 741
Query: 347 AHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTA---SEIEDLK--LENSSLQEKAAKA 401
+ + + S +++ E+ ++ + ++ SE++ L+ LE + Q K +
Sbjct: 742 NEQTKVI---DNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEI 798
Query: 402 GKNAEDVQHQILATESSNQE--YVRMLLDLQTKSALKET-------------EIKEITVS 446
KNAE + + E +E + +L S +KET E E VS
Sbjct: 799 EKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVS 858
Query: 447 FLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKP 506
+ + + N+L Q+EE F D E + + A+ E+ + EE K K
Sbjct: 859 VQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDER-----EEQLIKAKE 913
Query: 507 FQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLK 566
+L+ D E+ K + G QL K+ D L +++++ + K + S L+
Sbjct: 914 -KLENDIAEIMKMS-----GDNSSQLTKMNDELR--LKERDVEELQLKLTKANENASFLQ 965
Query: 567 SEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAF---HHESKE 611
+ + + + +Q K EE K L K D K H++ +E
Sbjct: 966 KSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQE 1013
Score = 90.5 bits (223), Expect = 4e-18
Identities = 147/666 (22%), Positives = 286/666 (42%), Gaps = 154/666 (23%)
Query: 19 IQDLETELEKMEARLNAALREKTSLS----ANNATLEKQLI-------ELTRTNELLKSK 67
+Q++ + EK+E RE TSL A T +K++ +L++ NE LKSK
Sbjct: 538 LQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSK 597
Query: 68 FSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLE 127
E+ N++N +++L KL E + Q+++EE +
Sbjct: 598 L-EHANKENSDVIALWKSKL------------------ETAIASHQQAMEELK------- 631
Query: 128 GKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQ 187
VS K E +E +L Q+EK +LD ENL+ + D +
Sbjct: 632 ---VSFSKGLGTETAEFAEL----------KTQIEKMRLDYQHEIENLQNQQDSERAAH- 677
Query: 188 SLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQER- 246
+K++E L K + KEKE+ + E + +++ + + ++E ++
Sbjct: 678 ---------AKEMEALRAKLMKVIKEKENSL-------EAIRSKLDKAEDQHLVEMEDTL 721
Query: 247 EKLQQKELQIDSLL-------QQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDEL 299
KLQ+ E+++ L +Q K + + Q + EE + + + + + E+
Sbjct: 722 NKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKAT--EEKLLDLDALRKASSEGKSEM 779
Query: 300 DKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEK-----SSAAHTQATL- 353
KL+Q+ E AE+ +K LE E + + + + +L+G+E +L S + + TL
Sbjct: 780 KKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLE 839
Query: 354 ----LLQEKYD-----------SMVQSLEDVTAQFESYKALTASEIEDLK---------- 388
+L+EK+ SM +++ + + E + L+ S++E L+
Sbjct: 840 KELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLS-SDLEKLRENLADMEAKF 898
Query: 389 LENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITV--- 445
E +E+ KA + E+ +I+ N + + D + LKE +++E+ +
Sbjct: 899 REKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND---ELRLKERDVEELQLKLT 955
Query: 446 ------SFLQK-ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEIN------- 491
SFLQK I D+ + +Q +++ K+ E+E K E E ++L +++
Sbjct: 956 KANENASFLQKSIEDMTVKAEQSQQEAAKKHEEE---KKELERKLSDLEKKMETSHNQCQ 1012
Query: 492 KWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQK 551
+ + YE ++TK ++ + ++ LL+ +++L R+ + LL Q L++
Sbjct: 1013 ELKARYERATSETKTKHEEI--LQNLQKTLLD----TEDKLKGAREENSGLL--QELEEL 1064
Query: 552 IKHVVKLKDENS---------QLKSEVSKLRCQLAKKKQSETKLQEEL-----NKVLGIK 597
K K K + Q+ E ++ L KQ+ KLQ EL N + ++
Sbjct: 1065 RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE 1124
Query: 598 HFDPSK 603
+ SK
Sbjct: 1125 ELNKSK 1130
Score = 35.0 bits (79), Expect = 0.21
Identities = 47/211 (22%), Positives = 90/211 (42%), Gaps = 31/211 (14%)
Query: 399 AKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETE---------IKEITVSFLQ 449
AKA NA +++AT S++ + L + S++ + + E + + +
Sbjct: 289 AKAKANAV---RRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYAR 345
Query: 450 KI---TDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYE-------E 499
KI T LQ LK++++ + L + + +AE T+ + E + L + E
Sbjct: 346 KISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLE 405
Query: 500 LYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLK 559
L K + ++A + EK LLN+ +E+ K+ D ++ K ++ KL+
Sbjct: 406 LEAKMDQLRTMVEAADREKVELLNQ---LEEEKRKVEDLQFRVEEESITKGDLETQTKLE 462
Query: 560 DENSQLKSEVSKLRCQLAKKKQSETKLQEEL 590
+ + +L L +K KLQ EL
Sbjct: 463 ------HARIKELEQSLLFEKTKADKLQREL 487
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 116 bits (290), Expect = 7e-26
Identities = 137/564 (24%), Positives = 266/564 (47%), Gaps = 86/564 (15%)
Query: 85 MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 142
MKL K + ++ ++E MK Q + L +S+ K +LE K+V++ KEK D +
Sbjct: 836 MKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL 895
Query: 143 ETEKLLEYIEEISCASDQVEKYKL-------DIAQLEENLKEKNDEILSLKQSLEENIVI 195
+ + E + + DQ+ K K+ ++ + E+ +E N E+ + K+ LE+
Sbjct: 896 QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955
Query: 196 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK--- 252
L K ++DL + +EKEK H N+ +NL EM L + +E++ LQ+
Sbjct: 956 LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1011
Query: 253 ----------------------ELQIDSL---LQQEKELSSSLHQK-------LCSFQEE 280
E Q+D L L+QEK+L L + L QE
Sbjct: 1012 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071
Query: 281 MV---KEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK 337
++ EK +E+LK+ E+ LQ K E + L QL+++ K ++ LEE+++ +
Sbjct: 1072 IMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAE 1131
Query: 338 EAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLK--LENSSLQ 395
A K+ + + L+E + + ++ +AQ E K A E + ++ LE ++LQ
Sbjct: 1132 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA-EFQKMRRDLEEATLQ 1190
Query: 396 EKAAKA---GKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKIT 452
+A A K+A+ V L + N + V+ L+ + KS +K EI ++ S ++ ++
Sbjct: 1191 HEATAATLRKKHADSVAE--LGEQIDNLQRVKQKLE-KEKSEMK-MEIDDL-ASNVETVS 1245
Query: 453 DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLD 512
+ L++ QL + + ++ E++ +LT + + L ++ F QLD
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGR-------LQTESGEFSRQLD 1298
Query: 513 AFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL----KSE 568
EK+AL++ QL++ + ++ + + + LK++++ +K K+ + + +
Sbjct: 1299 ----EKEALVS-------QLSRGKQAFTQQI--EELKRQLEEEIKAKNALAHALQSSRHD 1345
Query: 569 VSKLRCQLAKKKQSETKLQEELNK 592
LR Q ++++S+ +LQ L+K
Sbjct: 1346 CDLLREQYEEEQESKAELQRALSK 1369
Score = 104 bits (260), Expect = 2e-22
Identities = 135/641 (21%), Positives = 275/641 (42%), Gaps = 58/641 (9%)
Query: 1 MTLLIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRT 60
+T R L E + I DLE L K+E +A + +L+ A L++ + +LT+
Sbjct: 942 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKE 1001
Query: 61 NELLKSKFSENGNQKNLRILSLELMKLRNKRETKMR---------GMMAKQEGMEMKLQV 111
+ L + +Q+ L L E K+ + K++ G + +++ + M L+
Sbjct: 1002 KKAL-----QEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLER 1056
Query: 112 TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQL 171
+R L E K+AQ + EK+++DEK + ++ EIS ++E + QL
Sbjct: 1057 AKRKL-EGDLKLAQESIMDIENEKQQLDEKLKKKEF-----EISNLQSKIEDEQALGIQL 1110
Query: 172 EENLKEKNDEILSLKQSLE---ENIVILSKQVEDLNVKCQLLEKEKED---HVNRNREHN 225
++ +KE I L++ +E + KQ DL+ + + + + E+ + E N
Sbjct: 1111 QKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMN 1170
Query: 226 ENLNAEMQNLKQKF------------ILEQQEREKLQQKELQIDSL------LQQEKELS 267
+ AE Q +++ L ++ + + + QID+L L++EK
Sbjct: 1171 KKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEM 1230
Query: 268 SSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEEL 327
L S E + K K E+ + D+L +L+ KEE+ +RL+ L + E
Sbjct: 1231 KMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTES 1290
Query: 328 KLLEEKLKGKEA---ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYK---ALTA 381
+L KEA +L + A TQ L+ + + +++ + +S + L
Sbjct: 1291 GEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLR 1350
Query: 382 SEIEDLKLENSSLQEKAAKAGKNAED--VQHQILATESSNQ-EYVRMLLDLQTKSALKET 438
+ E+ + + LQ +KA +++ A + + + E + L + ++A +
Sbjct: 1351 EQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHV 1410
Query: 439 EIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYE 498
E + L+K + +L+ + ED +E A + + + +W+ E
Sbjct: 1411 EAVNAKCASLEK---TKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCE 1467
Query: 499 ELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGH-QNLKQKIKHVVK 557
E + + + Q + + E + N + + +QL ++ L +L ++I K
Sbjct: 1468 ETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGK 1527
Query: 558 LKDENSQLKSEVSKLRCQL-AKKKQSETKLQEELNKVLGIK 597
E ++K +V + +C+L A +++E L+ E K+L I+
Sbjct: 1528 RIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQ 1568
Score = 98.6 bits (244), Expect = 2e-20
Identities = 138/647 (21%), Positives = 286/647 (44%), Gaps = 84/647 (12%)
Query: 4 LIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN-- 61
LI L +RG + +L++ EA ++ R K + + L++QL E +
Sbjct: 1275 LINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNA 1334
Query: 62 ------------ELLKSKFSENGN-----QKNLRILSLELMKLRNKRETKMRGMMAKQEG 104
+LL+ ++ E Q+ L + E+ + R K ET + +E
Sbjct: 1335 LAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETD--AIQRTEEL 1392
Query: 105 MEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKY 164
E K ++ QR L+ ++ + + K S+EK K ++E E L+ +E + A ++K
Sbjct: 1393 EEAKKKLAQR-LQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKK 1451
Query: 165 KLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREH 224
+ + ++ K+K +E + ++ ++ L ++ K + +E D + +
Sbjct: 1452 QRNFDKILAEWKQKCEETHAELEASQKEARSLGTEL----FKIKNAYEESLDQLETLKRE 1507
Query: 225 NENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKE 284
N+NL E+ +L ++ + +L++ + Q++ Q++ EL ++L + S + E K
Sbjct: 1508 NKNLQQEISDLTEQIAEGGKRIHELEKIKKQVE---QEKCELQAALEEAEASLEHEEGKI 1564
Query: 285 KNLFEEELKQTLDELD-KLQQKEEQAERLVKQ-----------LEEEAKSRAEELKLLEE 332
+ + EL Q E+D K+ +K+E+ ++L + L+ E +SR + ++L ++
Sbjct: 1565 LRI-QLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL-KK 1622
Query: 333 KLKG--KEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLE 390
K++G E E++ + A A L Y + L+D + AL + E DLK +
Sbjct: 1623 KMEGDLNEMEIQLNHANRMAAEAL--RNYRNTQGILKDTQIHLDD--ALRSQE--DLKEQ 1676
Query: 391 NSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQK 450
+ ++ +A E+++ + TE S + + LLD + L T+ + + +
Sbjct: 1677 LAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKL 1736
Query: 451 ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK-------WRLLYEELYNK 503
TD+ +Q++ + ED ++ + E + + A + EE+ K + + +
Sbjct: 1737 ETDI-SQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1795
Query: 504 TKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQK---------IKH 554
K QL+LD E E+ AL ++Q+ K+ +L G +QK KH
Sbjct: 1796 VKDLQLRLD--EAEQLAL----KGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKH 1849
Query: 555 VVKLKDENSQ----------LKSEVSKLRCQLAKKKQSETKLQEELN 591
++K+ Q L+ V KL+ ++ K+ + +E+ N
Sbjct: 1850 ERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSN 1896
Score = 96.3 bits (238), Expect = 8e-20
Identities = 127/630 (20%), Positives = 267/630 (42%), Gaps = 88/630 (13%)
Query: 22 LETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILS 81
L+ ++++++AR+ E + A+ A EKQ +L+R E + + E G + +I
Sbjct: 1110 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI-- 1167
Query: 82 LELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG--------KIAQLEGKLVSI 133
++ KRE + + M E ++ + T +L + +I L+ +
Sbjct: 1168 ----EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKL 1223
Query: 134 EKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENI 193
EKEK + K E + L +E +S A +EK + D++ LK EE
Sbjct: 1224 EKEKSEMKMEIDDLASNVETVSKAKGNLEKM----------CRTLEDQLSELKSKEEEQ- 1272
Query: 194 VILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKE 253
+ + DL + L+ E + +R + E L +++ KQ F + +E ++ ++E
Sbjct: 1273 ---QRLINDLTAQRGRLQTESGEF-SRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEE 1328
Query: 254 LQIDSLL------------------QQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQT 295
++ + L ++E+E + L + L E+ + + +E + Q
Sbjct: 1329 IKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQR 1388
Query: 296 LDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLL 355
+EL++ ++K Q + ++ E ++ L+ +++L+ + +L A L
Sbjct: 1389 TEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAAL 1448
Query: 356 QEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILAT 415
+K ++ + + A+++ T +E+E + E SL + K E+ Q+
Sbjct: 1449 DKKQ----RNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETL 1504
Query: 416 ESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGR 475
+ N+ + + DL + A I E+ +++ + +L+ E+ LE EEG+
Sbjct: 1505 KRENKNLQQEISDLTEQIAEGGKRIHELE-KIKKQVEQEKCELQAALEEAEASLEHEEGK 1563
Query: 476 -----------KAEKENTTAELTEEINKWR------------LLYEELYNKTKPFQLQL- 511
K+E + AE EEI++ + L E+ ++ +L+
Sbjct: 1564 ILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKK 1623
Query: 512 ---DAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQ-NLKQKIKHVVKLKDENSQ--- 564
D E+E Q L + + A E L R++ L Q +L ++ LK++ +
Sbjct: 1624 MEGDLNEMEIQ-LNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVER 1682
Query: 565 ----LKSEVSKLRCQLAKKKQSETKLQEEL 590
L++E+ +LR L + ++S ++EL
Sbjct: 1683 RANLLQAEIEELRATLEQTERSRKIAEQEL 1712
Score = 64.7 bits (156), Expect = 2e-10
Identities = 84/408 (20%), Positives = 179/408 (43%), Gaps = 65/408 (15%)
Query: 9 LQERGAQDRRIQDLETELEKMEARLNAALRE-KTSLSANNATLEKQLIELTRTNELLKSK 67
+ E G + ++ ++ ++E+ + L AAL E + SL + + +EL + + K
Sbjct: 1522 IAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRK 1581
Query: 68 FSENGNQ----KNLRILSLELMKLRNKRETKMRG----MMAKQEG--MEMKLQV------ 111
+E + K I +E M+ E + R + K EG EM++Q+
Sbjct: 1582 IAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRM 1641
Query: 112 -----------------TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI 154
TQ L+++ L+ +L +E+ ++E E+L +E+
Sbjct: 1642 AAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQT 1701
Query: 155 SCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK 214
+ E+ LD ++ + L +N +++ K+ LE +I + ++ED+ + + E++
Sbjct: 1702 ERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKA 1761
Query: 215 E----------DHVNRNREHNENLNAEMQNLKQ-----KFILEQQEREKLQQKELQIDSL 259
+ + + + ++ + +L +N++Q + L++ E+ L+ + QI L
Sbjct: 1762 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKL 1821
Query: 260 LQQEKELSSSLHQ---------KLCSFQEEMVKEKNLFEEELKQTL----DELDKLQQKE 306
+ +EL + K E VKE EE ++ + D +DKLQ K
Sbjct: 1822 EARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKV 1881
Query: 307 EQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLL 354
+ +R ++ EE++ + + + L+ +L +EAE E++ A +Q L
Sbjct: 1882 KSYKRQAEEAEEQSNTNLAKFRKLQHEL--EEAE-ERADIAESQVNKL 1926
Score = 62.4 bits (150), Expect = 1e-09
Identities = 77/349 (22%), Positives = 153/349 (43%), Gaps = 42/349 (12%)
Query: 9 LQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEK-------QLIELTRTN 61
++ R R + +E +L +ME +LN A R N + L + R+
Sbjct: 1611 IRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQ 1670
Query: 62 ELLKSKFSENGNQKNLRILSLELMKLRNKRE-TKMRGMMAKQEGMEMKLQV--------- 111
E LK + + + NL L E+ +LR E T+ +A+QE ++ +V
Sbjct: 1671 EDLKEQLAMVERRANL--LQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1728
Query: 112 ---TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDI 168
T++ LE I+Q++G++ I +E ++ EK + I + + +++++K +
Sbjct: 1729 LINTKKKLETD---ISQMQGEMEDILQEA---RNAEEKAKKAITDAAMMAEELKKEQDTS 1782
Query: 169 AQLEENLKEKNDEILSLKQSLEENIVIL----SKQVEDLNVKCQLLEKEKEDHVNRNREH 224
A LE K + L+ L+E + KQ++ L + + LE E E RN E
Sbjct: 1783 AHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEA 1842
Query: 225 NENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKE 284
+ L + +K+ +++R+ + + + +D L + K EE ++
Sbjct: 1843 VKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQ--------AEEAEEQ 1894
Query: 285 KNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 333
N + ++ EL++ +++ + AE V +L KSR K++ E+
Sbjct: 1895 SNTNLAKFRKLQHELEEAEERADIAESQVNKL--RVKSREVHTKVISEE 1941
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 116 bits (290), Expect = 7e-26
Identities = 137/564 (24%), Positives = 266/564 (47%), Gaps = 86/564 (15%)
Query: 85 MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 142
MKL K + ++ ++E MK Q + L +S+ K +LE K+V++ KEK D +
Sbjct: 836 MKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL 895
Query: 143 ETEKLLEYIEEISCASDQVEKYKL-------DIAQLEENLKEKNDEILSLKQSLEENIVI 195
+ + E + + DQ+ K K+ ++ + E+ +E N E+ + K+ LE+
Sbjct: 896 QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955
Query: 196 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK--- 252
L K ++DL + +EKEK H N+ +NL EM L + +E++ LQ+
Sbjct: 956 LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1011
Query: 253 ----------------------ELQIDSL---LQQEKELSSSLHQK-------LCSFQEE 280
E Q+D L L+QEK+L L + L QE
Sbjct: 1012 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071
Query: 281 MV---KEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK 337
++ EK +E+LK+ E+ LQ K E + L QL+++ K ++ LEE+++ +
Sbjct: 1072 IMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAE 1131
Query: 338 EAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLK--LENSSLQ 395
A K+ + + L+E + + ++ +AQ E K A E + ++ LE ++LQ
Sbjct: 1132 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA-EFQKMRRDLEEATLQ 1190
Query: 396 EKAAKA---GKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKIT 452
+A A K+A+ V L + N + V+ L+ + KS +K EI ++ S ++ ++
Sbjct: 1191 HEATAATLRKKHADSVAE--LGEQIDNLQRVKQKLE-KEKSEMK-MEIDDL-ASNVETVS 1245
Query: 453 DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLD 512
+ L++ QL + + ++ E++ +LT + + L ++ F QLD
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGR-------LQTESGEFSRQLD 1298
Query: 513 AFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL----KSE 568
EK+AL++ QL++ + ++ + + + LK++++ +K K+ + + +
Sbjct: 1299 ----EKEALVS-------QLSRGKQAFTQQI--EELKRQLEEEIKAKNALAHALQSSRHD 1345
Query: 569 VSKLRCQLAKKKQSETKLQEELNK 592
LR Q ++++S+ +LQ L+K
Sbjct: 1346 CDLLREQYEEEQESKAELQRALSK 1369
Score = 104 bits (260), Expect = 2e-22
Identities = 135/641 (21%), Positives = 275/641 (42%), Gaps = 58/641 (9%)
Query: 1 MTLLIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRT 60
+T R L E + I DLE L K+E +A + +L+ A L++ + +LT+
Sbjct: 942 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKE 1001
Query: 61 NELLKSKFSENGNQKNLRILSLELMKLRNKRETKMR---------GMMAKQEGMEMKLQV 111
+ L + +Q+ L L E K+ + K++ G + +++ + M L+
Sbjct: 1002 KKAL-----QEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLER 1056
Query: 112 TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQL 171
+R L E K+AQ + EK+++DEK + ++ EIS ++E + QL
Sbjct: 1057 AKRKL-EGDLKLAQESIMDIENEKQQLDEKLKKKEF-----EISNLQSKIEDEQALGIQL 1110
Query: 172 EENLKEKNDEILSLKQSLE---ENIVILSKQVEDLNVKCQLLEKEKED---HVNRNREHN 225
++ +KE I L++ +E + KQ DL+ + + + + E+ + E N
Sbjct: 1111 QKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMN 1170
Query: 226 ENLNAEMQNLKQKF------------ILEQQEREKLQQKELQIDSL------LQQEKELS 267
+ AE Q +++ L ++ + + + QID+L L++EK
Sbjct: 1171 KKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEM 1230
Query: 268 SSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEEL 327
L S E + K K E+ + D+L +L+ KEE+ +RL+ L + E
Sbjct: 1231 KMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTES 1290
Query: 328 KLLEEKLKGKEA---ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYK---ALTA 381
+L KEA +L + A TQ L+ + + +++ + +S + L
Sbjct: 1291 GEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLR 1350
Query: 382 SEIEDLKLENSSLQEKAAKAGKNAED--VQHQILATESSNQ-EYVRMLLDLQTKSALKET 438
+ E+ + + LQ +KA +++ A + + + E + L + ++A +
Sbjct: 1351 EQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHV 1410
Query: 439 EIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYE 498
E + L+K + +L+ + ED +E A + + + +W+ E
Sbjct: 1411 EAVNAKCASLEK---TKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCE 1467
Query: 499 ELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGH-QNLKQKIKHVVK 557
E + + + Q + + E + N + + +QL ++ L +L ++I K
Sbjct: 1468 ETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGK 1527
Query: 558 LKDENSQLKSEVSKLRCQL-AKKKQSETKLQEELNKVLGIK 597
E ++K +V + +C+L A +++E L+ E K+L I+
Sbjct: 1528 RIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQ 1568
Score = 98.6 bits (244), Expect = 2e-20
Identities = 138/647 (21%), Positives = 286/647 (44%), Gaps = 84/647 (12%)
Query: 4 LIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN-- 61
LI L +RG + +L++ EA ++ R K + + L++QL E +
Sbjct: 1275 LINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNA 1334
Query: 62 ------------ELLKSKFSENGN-----QKNLRILSLELMKLRNKRETKMRGMMAKQEG 104
+LL+ ++ E Q+ L + E+ + R K ET + +E
Sbjct: 1335 LAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETD--AIQRTEEL 1392
Query: 105 MEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKY 164
E K ++ QR L+ ++ + + K S+EK K ++E E L+ +E + A ++K
Sbjct: 1393 EEAKKKLAQR-LQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKK 1451
Query: 165 KLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREH 224
+ + ++ K+K +E + ++ ++ L ++ K + +E D + +
Sbjct: 1452 QRNFDKILAEWKQKCEETHAELEASQKEARSLGTEL----FKIKNAYEESLDQLETLKRE 1507
Query: 225 NENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKE 284
N+NL E+ +L ++ + +L++ + Q++ Q++ EL ++L + S + E K
Sbjct: 1508 NKNLQQEISDLTEQIAEGGKRIHELEKIKKQVE---QEKCELQAALEEAEASLEHEEGKI 1564
Query: 285 KNLFEEELKQTLDELD-KLQQKEEQAERLVKQ-----------LEEEAKSRAEELKLLEE 332
+ + EL Q E+D K+ +K+E+ ++L + L+ E +SR + ++L ++
Sbjct: 1565 LRI-QLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL-KK 1622
Query: 333 KLKG--KEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLE 390
K++G E E++ + A A L Y + L+D + AL + E DLK +
Sbjct: 1623 KMEGDLNEMEIQLNHANRMAAEAL--RNYRNTQGILKDTQIHLDD--ALRSQE--DLKEQ 1676
Query: 391 NSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQK 450
+ ++ +A E+++ + TE S + + LLD + L T+ + + +
Sbjct: 1677 LAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKL 1736
Query: 451 ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK-------WRLLYEELYNK 503
TD+ +Q++ + ED ++ + E + + A + EE+ K + + +
Sbjct: 1737 ETDI-SQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1795
Query: 504 TKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQK---------IKH 554
K QL+LD E E+ AL ++Q+ K+ +L G +QK KH
Sbjct: 1796 VKDLQLRLD--EAEQLAL----KGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKH 1849
Query: 555 VVKLKDENSQ----------LKSEVSKLRCQLAKKKQSETKLQEELN 591
++K+ Q L+ V KL+ ++ K+ + +E+ N
Sbjct: 1850 ERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSN 1896
Score = 96.3 bits (238), Expect = 8e-20
Identities = 127/630 (20%), Positives = 267/630 (42%), Gaps = 88/630 (13%)
Query: 22 LETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILS 81
L+ ++++++AR+ E + A+ A EKQ +L+R E + + E G + +I
Sbjct: 1110 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI-- 1167
Query: 82 LELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG--------KIAQLEGKLVSI 133
++ KRE + + M E ++ + T +L + +I L+ +
Sbjct: 1168 ----EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKL 1223
Query: 134 EKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENI 193
EKEK + K E + L +E +S A +EK + D++ LK EE
Sbjct: 1224 EKEKSEMKMEIDDLASNVETVSKAKGNLEKM----------CRTLEDQLSELKSKEEEQ- 1272
Query: 194 VILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKE 253
+ + DL + L+ E + +R + E L +++ KQ F + +E ++ ++E
Sbjct: 1273 ---QRLINDLTAQRGRLQTESGEF-SRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEE 1328
Query: 254 LQIDSLL------------------QQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQT 295
++ + L ++E+E + L + L E+ + + +E + Q
Sbjct: 1329 IKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQR 1388
Query: 296 LDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLL 355
+EL++ ++K Q + ++ E ++ L+ +++L+ + +L A L
Sbjct: 1389 TEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAAL 1448
Query: 356 QEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILAT 415
+K ++ + + A+++ T +E+E + E SL + K E+ Q+
Sbjct: 1449 DKKQ----RNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETL 1504
Query: 416 ESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGR 475
+ N+ + + DL + A I E+ +++ + +L+ E+ LE EEG+
Sbjct: 1505 KRENKNLQQEISDLTEQIAEGGKRIHELE-KIKKQVEQEKCELQAALEEAEASLEHEEGK 1563
Query: 476 -----------KAEKENTTAELTEEINKWR------------LLYEELYNKTKPFQLQL- 511
K+E + AE EEI++ + L E+ ++ +L+
Sbjct: 1564 ILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKK 1623
Query: 512 ---DAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQ-NLKQKIKHVVKLKDENSQ--- 564
D E+E Q L + + A E L R++ L Q +L ++ LK++ +
Sbjct: 1624 MEGDLNEMEIQ-LNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVER 1682
Query: 565 ----LKSEVSKLRCQLAKKKQSETKLQEEL 590
L++E+ +LR L + ++S ++EL
Sbjct: 1683 RANLLQAEIEELRATLEQTERSRKIAEQEL 1712
Score = 64.7 bits (156), Expect = 2e-10
Identities = 84/408 (20%), Positives = 179/408 (43%), Gaps = 65/408 (15%)
Query: 9 LQERGAQDRRIQDLETELEKMEARLNAALRE-KTSLSANNATLEKQLIELTRTNELLKSK 67
+ E G + ++ ++ ++E+ + L AAL E + SL + + +EL + + K
Sbjct: 1522 IAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRK 1581
Query: 68 FSENGNQ----KNLRILSLELMKLRNKRETKMRG----MMAKQEG--MEMKLQV------ 111
+E + K I +E M+ E + R + K EG EM++Q+
Sbjct: 1582 IAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRM 1641
Query: 112 -----------------TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI 154
TQ L+++ L+ +L +E+ ++E E+L +E+
Sbjct: 1642 AAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQT 1701
Query: 155 SCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK 214
+ E+ LD ++ + L +N +++ K+ LE +I + ++ED+ + + E++
Sbjct: 1702 ERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKA 1761
Query: 215 E----------DHVNRNREHNENLNAEMQNLKQ-----KFILEQQEREKLQQKELQIDSL 259
+ + + + ++ + +L +N++Q + L++ E+ L+ + QI L
Sbjct: 1762 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKL 1821
Query: 260 LQQEKELSSSLHQ---------KLCSFQEEMVKEKNLFEEELKQTL----DELDKLQQKE 306
+ +EL + K E VKE EE ++ + D +DKLQ K
Sbjct: 1822 EARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKV 1881
Query: 307 EQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLL 354
+ +R ++ EE++ + + + L+ +L +EAE E++ A +Q L
Sbjct: 1882 KSYKRQAEEAEEQSNTNLAKFRKLQHEL--EEAE-ERADIAESQVNKL 1926
Score = 62.4 bits (150), Expect = 1e-09
Identities = 77/349 (22%), Positives = 153/349 (43%), Gaps = 42/349 (12%)
Query: 9 LQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEK-------QLIELTRTN 61
++ R R + +E +L +ME +LN A R N + L + R+
Sbjct: 1611 IRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQ 1670
Query: 62 ELLKSKFSENGNQKNLRILSLELMKLRNKRE-TKMRGMMAKQEGMEMKLQV--------- 111
E LK + + + NL L E+ +LR E T+ +A+QE ++ +V
Sbjct: 1671 EDLKEQLAMVERRANL--LQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1728
Query: 112 ---TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDI 168
T++ LE I+Q++G++ I +E ++ EK + I + + +++++K +
Sbjct: 1729 LINTKKKLETD---ISQMQGEMEDILQEA---RNAEEKAKKAITDAAMMAEELKKEQDTS 1782
Query: 169 AQLEENLKEKNDEILSLKQSLEENIVIL----SKQVEDLNVKCQLLEKEKEDHVNRNREH 224
A LE K + L+ L+E + KQ++ L + + LE E E RN E
Sbjct: 1783 AHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEA 1842
Query: 225 NENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKE 284
+ L + +K+ +++R+ + + + +D L + K EE ++
Sbjct: 1843 VKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQ--------AEEAEEQ 1894
Query: 285 KNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 333
N + ++ EL++ +++ + AE V +L KSR K++ E+
Sbjct: 1895 SNTNLAKFRKLQHELEEAEERADIAESQVNKL--RVKSREVHTKVISEE 1941
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 114 bits (286), Expect = 2e-25
Identities = 154/652 (23%), Positives = 292/652 (44%), Gaps = 94/652 (14%)
Query: 9 LQERGAQDRRIQDLETELEK----MEARLNAALRE-------KTSLSANNATLEKQLIEL 57
L E G Q R ++ +++EK ++ R+N R+ + ++ +TL+ QL +L
Sbjct: 467 LDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDL 526
Query: 58 ---TRTNELLKSKFSENGNQKN-----LRILSLELMKLRNKRETKMRGMMAKQEGMEMKL 109
++ ++L K S+ Q LR S ++LR K T+M +++ E + +L
Sbjct: 527 KKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLR-KSHTEMSKSISQLESLNREL 585
Query: 110 QVTQRSLEESQGKIAQLEGKLVSI-EKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDI 168
Q R LE S+ + + +L +I E E+ D ++E + + I+ ++V+ K ++
Sbjct: 586 QERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNL 645
Query: 169 AQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENL 228
++E KE D +L+ + + N+ I DLN K + L++ E VN ++ L
Sbjct: 646 EKVEGERKEAQD-MLNHSEKEKNNLEI------DLNYKLKSLQQRLEQEVNEHKVTKARL 698
Query: 229 NAEMQNLKQ-----------KFILEQQEREKLQQKELQID---SLLQQEKELSSSLHQKL 274
+ Q++++ K E++ REK + + +QI+ S+L + + S + L
Sbjct: 699 TDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHL 758
Query: 275 CSFQEEMVKE-KNL-------------FEEELKQTLDELDKLQQKEEQAERLVKQLEEEA 320
+E M E KNL + ELK E D L+ E+Q ++ + L E
Sbjct: 759 TGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAK 818
Query: 321 KSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALT 380
+ EL L ++ +G E ++ + +A Y + V+ L++ + E
Sbjct: 819 RLLEFELAQLTKQYRGNEGQM-RELQDQLEAEQYFSTLYKTQVKELKE---EIEEKNREN 874
Query: 381 ASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEI 440
+I++L+ E +L + A AE Q LA ++Y + + + ++ EI
Sbjct: 875 LKKIQELQNEKETLATQLDLAETKAESEQ---LARGLLEEQYFELTQESKKAASRNRQEI 931
Query: 441 --KEITVSFLQKIT-----DLQNQLKQQEEDFRKQLEDEEGRKAEKE----NTTAELTEE 489
K+ TVS L++ D++ ++ EE K + EE K EKE N A +
Sbjct: 932 TDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKN 991
Query: 490 INKWRLLYEELYNKTKPFQLQLDAFEVEKQAL--------LNEHGAAQEQLNKIRDSYAK 541
IN R L + NK + D F+++++ E+ Q +LN+ R+ + +
Sbjct: 992 INTERTLKTQAVNKLAEIMNRKD-FKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQ 1050
Query: 542 LLGHQNLKQKIKHVVKLKDENSQLKSEV---SKLRCQLAKKKQSETKLQEEL 590
++ +KH +L D +QL E ++L+ QLA K+ +L+ +L
Sbjct: 1051 MV--------VKHQKELNDMQAQLVEECAHRNELQMQLASKESDIEQLRAKL 1094
Score = 97.4 bits (241), Expect = 3e-20
Identities = 130/581 (22%), Positives = 253/581 (43%), Gaps = 73/581 (12%)
Query: 66 SKFSENGNQKNLRILSLELMKLRNKRETKMR---GMMAKQEGMEMKLQVTQRSLEESQGK 122
++ S N ++ L + KL + +M+ M K +KL + L+E +
Sbjct: 414 NRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQ 473
Query: 123 IAQLEGKLVSIEKEKI-----------DEKSETEKLLEYIEEISCASDQVEKYKLDIAQL 171
LE + IEKEK+ + E EK E+S DQ+E D+ ++
Sbjct: 474 RRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLE----DLKKV 529
Query: 172 EENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAE 231
+N + N+++ L++ LEE +L + D V+ ++ ++++ E+LN E
Sbjct: 530 SQNSQLANEKLSQLQKQLEEANDLLRTE-SDTAVRL----RKSHTEMSKSISQLESLNRE 584
Query: 232 MQNLKQKFILEQQEREKLQQKELQIDSLLQQEK-------ELSSSLHQKLCSFQEEMVKE 284
+Q ++ ILE + + + Q+ ++L+ E+ E+ L ++ S QEE+
Sbjct: 585 LQ--ERNRILE-NSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHL 641
Query: 285 KNLFEEELKQTLDELDKLQQKEEQAERL-------VKQLEEEAKSRAEELKLLEEKLKGK 337
K+ E+ + + D L E++ L +K L++ + E K+ + +L K
Sbjct: 642 KHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDK 701
Query: 338 EAELEKS-SAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQE 396
+E++ S A + L+E+ ++ + E+ Q E K + ++ DLK L+
Sbjct: 702 HQSIEEAKSVAMCEMEKKLKEEREAR-EKAENRVVQIE--KQCSMLDV-DLKQSQQKLEH 757
Query: 397 KAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKS----ALK--ETEIKEITVSFLQK 450
+ ++V++ L E + + + + +L+T++ LK E ++K+ + L+
Sbjct: 758 LTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEA 817
Query: 451 ITDLQNQLKQ----------QEEDFRKQLEDEEGRKAEKENTTAELTEEI---NKWRL-L 496
L+ +L Q Q + + QLE E+ + EL EEI N+ L
Sbjct: 818 KRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKK 877
Query: 497 YEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLL--GHQNLKQKIKH 554
+EL N+ + QLD E + ++ G +EQ ++ K Q + K
Sbjct: 878 IQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHT 937
Query: 555 VVKLKDENSQLKSEVSKLR------CQLAKKKQSETKLQEE 589
V +L++ NS L ++ LR + KK + E KL++E
Sbjct: 938 VSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKE 978
Score = 57.0 bits (136), Expect = 5e-08
Identities = 75/340 (22%), Positives = 153/340 (45%), Gaps = 42/340 (12%)
Query: 276 SFQEEMVKEKNLFEEELKQTLDELDKLQQK----EEQAERLVKQLEEEAKSRAEELKLLE 331
S QE + K EE+L + D+++QK + ++++K+L+EE R
Sbjct: 423 SLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQR-------- 474
Query: 332 EKLKGKEAELEKSSAAHTQATLLLQEK---YDSMVQSLEDVTAQFESYKALTASEIEDLK 388
L+ +++EK +LLQ + Y + + E+ + ++EDLK
Sbjct: 475 RNLESTVSQIEKEK-------MLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLK 527
Query: 389 --LENSSL-QEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITV 445
+NS L EK ++ K E+ + +L TES +R +KS ++++ +
Sbjct: 528 KVSQNSQLANEKLSQLQKQLEEA-NDLLRTESDTAVRLRKSHTEMSKSI---SQLESLNR 583
Query: 446 SFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTK 505
++ L+N Q ++D+ + E + ++ + +E I + L + K
Sbjct: 584 ELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHD----SEMIGDLQARITSLQEEVK 639
Query: 506 PFQLQLDAFEVEK---QALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKI-KHVV---KL 558
+ L+ E E+ Q +LN H ++ +I +Y Q L+Q++ +H V +L
Sbjct: 640 HLKHNLEKVEGERKEAQDMLN-HSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARL 698
Query: 559 KDENSQLKSEVSKLRCQLAKKKQSETKLQEEL-NKVLGIK 597
D++ ++ S C++ KK + E + +E+ N+V+ I+
Sbjct: 699 TDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIE 738
Score = 45.4 bits (106), Expect = 2e-04
Identities = 47/235 (20%), Positives = 109/235 (46%), Gaps = 9/235 (3%)
Query: 9 LQERGAQD-RRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSK 67
++E+ ++ ++IQ+L+ E E + +L+ A + S LE+Q ELT+ ++ S+
Sbjct: 867 IEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASR 926
Query: 68 FSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLE 127
+ K+ + LE ++ + + ++E E+ ++ + E K ++
Sbjct: 927 NRQEITDKDHTVSRLEEANSMLTKDIE----ILRRENEELTEKMKKAEEEYKLEKEEEIS 982
Query: 128 GKLVSIEKEKIDEKSETEKLLEYIEEISCASD-QVEKYKLDIAQLEENLKEKNDEILSLK 186
+ EK E++ + + + EI D ++++ K + L + KE L L
Sbjct: 983 NLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELN 1042
Query: 187 QSLEE-NIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFI 240
Q E+ N +++ Q E +++ QL+E+ H N + + ++++ L+ K +
Sbjct: 1043 QEREKFNQMVVKHQKELNDMQAQLVEECA--HRNELQMQLASKESDIEQLRAKLL 1095
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 114 bits (286), Expect = 2e-25
Identities = 132/569 (23%), Positives = 250/569 (43%), Gaps = 64/569 (11%)
Query: 85 MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKID--- 139
M L K + ++ A++E MK + T+ L S+ + +LE K+VS+ +EK D
Sbjct: 834 MNLFFKIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQL 893
Query: 140 -EKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEK---NDEILSLKQSLEENIVI 195
+SETE L++ E + + +L E L+E+ N E+++ K++LE+
Sbjct: 894 QVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSS 953
Query: 196 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNL----KQKFILE---QQEREK 248
L + ++DL + +EKEK N+ + +E + A +N+ K+K L+ QQ +
Sbjct: 954 LKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDD 1013
Query: 249 LQQKELQIDSLL-------QQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDK 301
LQ +E +++ L+ QQ +L SL Q+ + ++ + K E +LK + + +
Sbjct: 1014 LQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEK-KLRADLERAKRKLEGDLKMSQESIMD 1072
Query: 302 LQQKEEQAERLVKQLEEE-----AKSRAEELKLLEEKLKGKE-----AELEKSSAAHTQA 351
L+ ++Q E +K+ E E AK E++ L+ + K KE ELE+ A
Sbjct: 1073 LENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTL 1132
Query: 352 TLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLK------------LENSSLQEKAA 399
++++ + + LE+++ + E T+++IE K LE ++LQ +A
Sbjct: 1133 RAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEAT 1192
Query: 400 KA---GKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQK------ 450
A K A+ V L + N + V+ L+ + E + + L K
Sbjct: 1193 AATLRKKQADSVAE--LGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIE 1250
Query: 451 -----ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTK 505
+ D +++K ++E + + D +KA + EL+ + + L +L +
Sbjct: 1251 RTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQ 1310
Query: 506 PFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL 565
QL+ + + + A L R L +Q+ K +L+ S+
Sbjct: 1311 ALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAK--AELQRALSKA 1368
Query: 566 KSEVSKLRCQLAKKKQSETKLQEELNKVL 594
SEV++ R + T+ EE K L
Sbjct: 1369 NSEVAQWRTKYETDAIQRTEELEEAKKKL 1397
Score = 104 bits (260), Expect = 2e-22
Identities = 130/622 (20%), Positives = 270/622 (43%), Gaps = 77/622 (12%)
Query: 17 RRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKN 76
++I++L+ +E++E + A E T A +EKQ +L R E + + E +
Sbjct: 1110 KKIKELQARIEELEEEIEA---EHTL----RAKIEKQRSDLARELEEISERLEEASGATS 1162
Query: 77 LRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG--------KIAQLEG 128
+I ++ KRE + + M E ++ + T +L + Q +I L+
Sbjct: 1163 AQI------EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQR 1216
Query: 129 KLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQS 188
+EKEK + K E + + IE +S + +E+ + +K K+++ L
Sbjct: 1217 VKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHD 1276
Query: 189 LEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREK 248
L L Q +L+ + + EKE +++ + + L +++ LK++ +E++ + K
Sbjct: 1277 LNMQKARLQTQNGELSHRVE----EKESLISQLTKSKQALTQQLEELKRQ--MEEETKAK 1330
Query: 249 ------LQQKELQIDSLLQQ---EKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDEL 299
LQ D L +Q E+E + L + L E+ + + +E + Q +EL
Sbjct: 1331 NAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEEL 1390
Query: 300 DKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKS-SAAHTQATLLLQEK 358
++ ++K Q + ++ E A S+ L+ +++L+G+ +L + +HT L
Sbjct: 1391 EEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATL---- 1446
Query: 359 YDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESS 418
D ++ + V A+++ + +E+E + E+ SL + K E+V Q+
Sbjct: 1447 -DKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRE 1505
Query: 419 NQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAE 478
N+ + DL TE T LQ+ + ++Q++ D + LE+ EG
Sbjct: 1506 NKNLQEEISDL--------TEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEH 1557
Query: 479 KENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDS 538
+E+ + E+++ + EL K ++ E +Q N AA E L + D+
Sbjct: 1558 EESKILRVQLELSQ---VKSELDRKV------IEKDEEIEQLKRNSQRAA-EALQSVLDA 1607
Query: 539 YAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLG-IK 597
+ +N ++K +++ +++++ QL + + Q+ L V G +K
Sbjct: 1608 EIR---SRNDALRLK---------KKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLK 1655
Query: 598 ----HFDPSKAFHHESKENFAL 615
H D + + + KE A+
Sbjct: 1656 DSQLHLDDALRSNEDLKEQLAI 1677
Score = 102 bits (255), Expect = 8e-22
Identities = 133/658 (20%), Positives = 278/658 (42%), Gaps = 67/658 (10%)
Query: 17 RRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKN 76
R I DLE L K+E +A + +LS LE+ + +LT+ + K + +Q+
Sbjct: 956 RDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTK-----EKKSLQEAHQQT 1010
Query: 77 LRILSLE------LMKLRNKRETK---MRGMMAKQEGMEMKLQVTQRSLE----ESQGKI 123
L L +E L+K+ K E + + G + +++ + L+ +R LE SQ I
Sbjct: 1011 LDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESI 1070
Query: 124 AQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEIL 183
LE IE++ ++ E +L I++ S Q +K ++ E L+E+ +
Sbjct: 1071 MDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEH 1130
Query: 184 SLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ 243
+L+ +E+ L++++E+++ + + + N++ ++L++ + +
Sbjct: 1131 TLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHE 1190
Query: 244 QEREKLQQKEL--------QIDSL------LQQEKELSSSLHQKLCSFQEEMVKEKNLFE 289
L++K+ QID+L L++EK + S E + K K+ E
Sbjct: 1191 ATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIE 1250
Query: 290 EELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKE---AELEKSSA 346
+ D+ +++ K+EQ +L+ L + + L +++ KE ++L KS
Sbjct: 1251 RTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQ 1310
Query: 347 AHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAE 406
A TQ L+ + + E+ A+ AL +S + L +E+ AKA
Sbjct: 1311 ALTQQLEELKRQME------EETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKA----- 1359
Query: 407 DVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFR 466
++Q A +N E + +T + + E++E Q++ + + +
Sbjct: 1360 ELQR---ALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCA 1416
Query: 467 KQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTK---PFQLQLDAFEVEKQALLN 523
+ ++ + E E+ +L L ++ N K ++ +LD + E +A
Sbjct: 1417 SLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQK 1476
Query: 524 EHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLA------ 577
E + +L K+R++Y ++ + + L+ EN L+ E+S L Q+A
Sbjct: 1477 ESRSLSTELFKMRNAY---------EEVVDQLETLRRENKNLQEEISDLTEQIAETGKNL 1527
Query: 578 KKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQE 635
++ + KL E+ L + + + HE + ++ L + + R +E E
Sbjct: 1528 QEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDE 1585
Score = 79.3 bits (194), Expect = 1e-14
Identities = 113/509 (22%), Positives = 219/509 (43%), Gaps = 78/509 (15%)
Query: 11 ERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSE 70
E A + + L TEL KM + + +L N L++++ +LT + +E
Sbjct: 1470 ELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLT-------EQIAE 1522
Query: 71 NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKL 130
G +N +E + + +QE ++ Q +LEE +G + E K+
Sbjct: 1523 TG---------------KNLQEAEKTKKLVEQEKSDL-----QVALEEVEGSLEHEESKI 1562
Query: 131 VSIEKEKIDEKSETE-KLLEYIEEISCASDQVEKYKLDIAQ-----LEENLKEKNDEILS 184
+ ++ E KSE + K++E EEI +Q+++ A+ L+ ++ +ND L
Sbjct: 1563 LRVQLELSQVKSELDRKVIEKDEEI----EQLKRNSQRAAEALQSVLDAEIRSRND-ALR 1617
Query: 185 LKQSLEENIVILSKQVEDLN------------VKCQLLEKEKEDHVNRNREHNENLNAEM 232
LK+ +E ++ + Q+ N V+ QL K+ + H++ NE+L ++
Sbjct: 1618 LKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQL--KDSQLHLDDALRSNEDLKEQL 1675
Query: 233 QNLKQK--FILEQQEREKLQQKELQIDSLLQQEKELSSSLH-QKLCSFQEEMVKEKNLFE 289
++++ +LE+ E K+ ++ + L +++ L +S Q L S ++ K E
Sbjct: 1676 AIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLE 1735
Query: 290 EELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHT 349
++ Q E++ Q+ AE K+ +A AEELK K + A LE+
Sbjct: 1736 ADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELK----KEQDTSAHLERMKKNLE 1791
Query: 350 QATLLLQEKYDSMVQ-SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDV 408
Q LQ + D Q +L+ Q + + + + +L+ E Q++ A+A K A
Sbjct: 1792 QTVKDLQHRLDEAEQLALKGGKKQIQKLE----NRVRELENELDVEQKRGAEALKGAHKY 1847
Query: 409 QHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQ 468
+ ++ +E + +L LQ ++ K+ + Q ++ EE Q
Sbjct: 1848 ERKVKEMTYQAEEDHKNILRLQ-----------DLVDKLQAKVKSYKRQAEEAEEQANTQ 1896
Query: 469 LEDEEGRKAEKENTT--AELTE-EINKWR 494
L + E E A++ E ++NK R
Sbjct: 1897 LSRCRRVQHELEEAAERADIAESQVNKLR 1925
Score = 67.4 bits (163), Expect = 4e-11
Identities = 85/412 (20%), Positives = 174/412 (42%), Gaps = 48/412 (11%)
Query: 6 RVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLK 65
+++ QE+ ++++E LE E+++ LR + LS + L++++IE E LK
Sbjct: 1535 KLVEQEKSDLQVALEEVEGSLEHEESKI---LRVQLELSQVKSELDRKVIEKDEEIEQLK 1591
Query: 66 SKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQ 125
S+ + +L E+ + RN + M ME++L + R + E+Q +
Sbjct: 1592 RN-SQRAAEALQSVLDAEI-RSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRT 1649
Query: 126 LEGKLVSIEKEKIDEKSETEKLLEYIEEISCAS----DQVEKYKLDIAQLEENLKEKNDE 181
++G+L + D E L E + + + +++E+ K+ + Q E + E
Sbjct: 1650 VQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQE 1709
Query: 182 ILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENL---NAEMQNLKQK 238
+L D + + QLL + +N ++ ++ AE++N Q+
Sbjct: 1710 LL------------------DASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQE 1751
Query: 239 FILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDE 298
+++ +K + L++E++ S+ L E M K ++L+ LDE
Sbjct: 1752 SRNAEEKAKKAITDAAMMAEELKKEQDTSAHL--------ERMKKNLEQTVKDLQHRLDE 1803
Query: 299 LDKL---------QQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHT 349
++L Q+ E + L +L+ E K AE LK K + K E+ +
Sbjct: 1804 AEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALK-GAHKYERKVKEMTYQAEEDH 1862
Query: 350 QATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKA 401
+ L LQ+ D + ++ Q E + +++ + L+E A +A
Sbjct: 1863 KNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERA 1914
Score = 30.0 bits (66), Expect = 6.8
Identities = 36/159 (22%), Positives = 69/159 (43%), Gaps = 26/159 (16%)
Query: 448 LQKITDLQNQLKQQEEDFRKQLED---EEGRKAEKENTTAELTEEINKWRLLYEELYNKT 504
L K + + ++ +EDF + E+ E R+ E E L +E N
Sbjct: 843 LLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKND------------ 890
Query: 505 KPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQ 564
QLQ+ + E + L++ A+E+ + S K+L +K+ + + + ++ NS+
Sbjct: 891 --LQLQVQS---ETENLMD----AEERCEGLIKS--KILLEAKVKELTERLEEEEEMNSE 939
Query: 565 LKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSK 603
L ++ L + + K+ L+ L KV KH +K
Sbjct: 940 LVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENK 978
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 114 bits (284), Expect = 4e-25
Identities = 153/635 (24%), Positives = 286/635 (45%), Gaps = 95/635 (14%)
Query: 14 AQDRRIQDLETELEKMEARLNAALRE-KTSLSANNATLEK-QLIELTRTNELLKSKFSEN 71
AQ + IQ+L+ EK+ +L ++E K + NNAT L++ T K+K E
Sbjct: 143 AQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEY 202
Query: 72 GNQKNLRILSLELMKLRNKRETKMRG-----MMAKQEGMEMKLQVTQ-----RSLEESQG 121
++ ++ M L N E + + A+ +EM ++ + + LE+
Sbjct: 203 EREETRQV----YMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYK 258
Query: 122 KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQV----EKYKLDIAQLEENLKE 177
K + K VS+ +I EK K L ++ E S D+V EK KL L++++++
Sbjct: 259 KEINDKEKQVSLLLIQITEKENKMKDLTFLLEES--RDKVNQLEEKTKLQSENLKQSIEK 316
Query: 178 KN---DEILSLKQSLEENIVILSKQVEDLNVK----CQLLEKEKE---DHVNRNREHNEN 227
++ E+ +K SL+ ++ EDL + CQL E EKE + N+ R +
Sbjct: 317 QHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTE-EKETQMEESNKARAAHSF 375
Query: 228 LNAEMQNLKQKF-ILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKN 286
+ E + L + E+++L++ E Q+ L + ++ SS L + ++ K
Sbjct: 376 VVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEE-----MTKLTNNKE 430
Query: 287 LFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSA 346
+ EELK+ L E + L + +Q E++ AEELK E++L G EK
Sbjct: 431 VELEELKKVLGEKETLLYENKQFEKI-----------AEELKGTEQELIGLLQAREK--- 476
Query: 347 AHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLK--LENSSLQEKAAKAGKN 404
E +D +Q L +T + Y + E++DLK LEN L+ + N
Sbjct: 477 ----------EVHDLEIQ-LTAITTSEQYY----SKEVKDLKTELENEKLKNTELTSHCN 521
Query: 405 AEDVQHQILATESSNQ--EYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQE 462
++++ L E+S+ E D+ +E +K+I + + T L+N+L+
Sbjct: 522 KLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIE-NLQETETQLRNELEYVR 580
Query: 463 EDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQ-------LQLDAFE 515
E+ +++ ++ + + + E L +++ EEL + K + QL+ +E
Sbjct: 581 EELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYE 640
Query: 516 VEKQALLNEHGAAQEQLNKIRDSYA-----KLLGHQNLKQKIKHVVKLKDENSQLKSEVS 570
++ L E +A+++ +I D+Y K + +NL ++++ + DE +L+ E+
Sbjct: 641 IKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEID 700
Query: 571 KLRCQ---------LAKKKQSETKLQEELNKVLGI 596
K RCQ + K K K+ EE + LG+
Sbjct: 701 K-RCQHKIAEMVALMEKHKHQYDKIIEERDSELGL 734
Score = 72.8 bits (177), Expect = 9e-13
Identities = 92/445 (20%), Positives = 194/445 (43%), Gaps = 58/445 (13%)
Query: 4 LIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNEL 63
++ + LQ++ ++ + L E L L EK +L N EK EL T +
Sbjct: 407 ILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQE 466
Query: 64 LKSKFSENGNQKNLRILSLELMKL--------RNKRETKMRGMMAKQEGMEMKLQVTQRS 115
L +K + L ++L + + ++ K K + E+ + S
Sbjct: 467 LIGLLQ--AREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLS 524
Query: 116 LEESQ--GKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEE 173
LE + + + + +L + +++ + K + E++L+ IE + Q+ ++ + E
Sbjct: 525 LENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRN---ELEYVRE 581
Query: 174 NLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQ 233
LK+K DE+ EEN L KQVE+ N + L++E + + ++ LN
Sbjct: 582 ELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVY-- 639
Query: 234 NLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELK 293
K+ + EL+++S Q+ E++ + +Q+E +++K + EE L
Sbjct: 640 ------------EIKVNKLELELESAKQKFGEITDT-------YQKE-IEDKKISEENL- 678
Query: 294 QTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATL 353
L+E++K + ++A +L K++++ + + E+ L EK K Q
Sbjct: 679 --LEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKH-------------QYDK 723
Query: 354 LLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQIL 413
+++E+ DS + + + S +A E+ +LK E S++++ + E ++ +
Sbjct: 724 IIEER-DSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKRE-- 780
Query: 414 ATESSNQEYVRMLLDLQTKSALKET 438
N ++ D +T++ L ET
Sbjct: 781 --AKENTATLKEKKDKKTQTFLLET 803
Score = 53.5 bits (127), Expect = 6e-07
Identities = 68/311 (21%), Positives = 139/311 (44%), Gaps = 16/311 (5%)
Query: 20 QDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRI 79
++L+ + ++++ +L+ + +L K + EL + N+ LK K + Q N+
Sbjct: 581 EELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYE 640
Query: 80 LSLELMKLRNKRETKMRGMMAKQEGMEMK-LQVTQRSLEESQGKIAQLEGKLVSIEKEKI 138
+ + ++L + + G + E++ ++++ +L E K + + V ++KE I
Sbjct: 641 IKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKE-I 699
Query: 139 DEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENL---KEKNDEILSLKQSLEENIVI 195
D++ + K+ E + + Q +K I + + L K K E SL+ SLE I +
Sbjct: 700 DKRCQ-HKIAEMVALMEKHKHQYDKI---IEERDSELGLYKSKEQEQSSLRASLE--IEL 753
Query: 196 LSKQVEDLNVKCQL-LEKEKEDHVNRN-REHNENLNAEMQNLKQKFILEQQE-REKLQQK 252
+ + E L+VK QL +E+E+++ + R +E+ L + Q F+LE E KL K
Sbjct: 754 SNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPEIYWKLDSK 813
Query: 253 ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 312
+ ++ + + + + + KN L + + K +Q E L
Sbjct: 814 AVPSQTVSRNFTSVDHGISKDKRDYL--WTSAKNTLSTPLPKAYTVKTPTKPKLQQRENL 871
Query: 313 VKQLEEEAKSR 323
+EE K R
Sbjct: 872 NIPIEESKKKR 882
Score = 32.3 bits (72), Expect = 1.4
Identities = 32/172 (18%), Positives = 79/172 (45%), Gaps = 11/172 (6%)
Query: 428 DLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELT 487
D + LK+++++ + ++ + ++L ++ E +K E +KE+ E
Sbjct: 84 DCHYQEGLKDSDLENS-----EGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENR 138
Query: 488 EEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYA----KLL 543
+ I R +EL + L+L+ E + L+ E+ A + N ++++ A K
Sbjct: 139 KIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTK 198
Query: 544 GHQNLKQKIKHV-VKLKDENSQLKSEVSKLRCQLAKKK-QSETKLQEELNKV 593
++ +++ + V + L + ++ + +LR Q + + KL+E+ K+
Sbjct: 199 KYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKI 250
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 112 bits (279), Expect = 1e-24
Identities = 148/693 (21%), Positives = 295/693 (42%), Gaps = 117/693 (16%)
Query: 8 LLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLI-------ELTRT 60
L E+ + IQ+LE +LE+ E+ EK + A LE++ I +L +
Sbjct: 934 LQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKE 993
Query: 61 NELLKSKFSE-NGNQKNLRILSLELMKLRNKRE---TKMRGMMAKQEGMEMKLQVTQRSL 116
+LL+ + +E N S L KL+NK E T + + ++E +L+ T+R L
Sbjct: 994 KKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKL 1053
Query: 117 E-----------ESQGKIAQLEGKLVSIEKE------KIDE---------------KSET 144
E E Q +IA+L+ +L E+E +++E +S+
Sbjct: 1054 EGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQI 1113
Query: 145 EKLLEYIEEISCASDQVEKYKLDIAQLEENLK------------------EKNDEILSLK 186
+L E +E + ++ EK K D+ + E LK ++ E+ LK
Sbjct: 1114 SELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILK 1173
Query: 187 QSLEENIVILSKQVEDLNVK-------------------------CQLLEKEKEDHVNR- 220
++LEE Q++++ K Q LE E+ + N
Sbjct: 1174 KTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEV 1233
Query: 221 --------NREH-NENLNAEMQNLKQKFILEQQEREKLQQK--ELQID-----SLLQQEK 264
+ EH + + A++Q L+ KF ++ R +L K +LQ++ LL Q
Sbjct: 1234 KVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSD 1293
Query: 265 ELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSR- 323
SS L + + + ++ + L +EE +Q L KL+Q E++ +QLEEE +++
Sbjct: 1294 SKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKH 1353
Query: 324 --AEELKLLEEKLKGKEAELEKSSAAHTQATLL---LQEKYDSMVQSLEDVTAQF---ES 375
+++ L ++ + ++E S A + LQ+ + + Q E+ A + E
Sbjct: 1354 NLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEK 1413
Query: 376 YKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSAL 435
K E++DL ++ ++ A K + + ++ + +Y + ++
Sbjct: 1414 TKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEARE 1473
Query: 436 KETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRL 495
KET+ + + L++ + + +L++ + FR ++ED K + + EL +
Sbjct: 1474 KETKALSLARA-LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQ 1532
Query: 496 LYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHV 555
EE+ + + + +L A E K L A + Q RD + Q+ ++K + V
Sbjct: 1533 QVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE--RDLQGR--DEQSEEKKKQLV 1588
Query: 556 VKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 588
++++ ++L+ E + +A +K+ E L++
Sbjct: 1589 RQVREMEAELEDERKQRSMAVAARKKLEMDLKD 1621
Score = 111 bits (277), Expect = 2e-24
Identities = 127/634 (20%), Positives = 287/634 (45%), Gaps = 60/634 (9%)
Query: 5 IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL 64
++VLLQ +G + + + +E +L++++ + N R +T L+ L+ +EL LL
Sbjct: 1233 VKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQ---VELDNVTGLL 1289
Query: 65 KSKFSENGN-QKNLRILSLELM---KLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQ 120
S++ K+ L +L +L + + + K + +E + + LEE +
Sbjct: 1290 SQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEE 1349
Query: 121 GKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND 180
LE ++ ++ + D K + E + + C + E+ K + + E L ++++
Sbjct: 1350 EAKHNLEKQIATLHAQVADMKKKME------DSVGCL-ETAEEVKRKLQKDLEGLSQRHE 1402
Query: 181 EILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFI 240
E ++ LE+ L ++++DL V +++ ++ + ++ + L AE + + K+
Sbjct: 1403 EKVAAYDKLEKTKTRLQQELDDLLVDLDH-QRQSACNLEKKQKKFDQLLAEEKTISAKYA 1461
Query: 241 LEQQERE----KLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL 296
E+ E + + K L + L++ E + L + F+ EM ++ ++++ +++
Sbjct: 1462 EERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEM-EDLMSSKDDVGKSV 1520
Query: 297 DELDK----LQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQAT 352
EL+K L+Q+ E+ + +++LE+E ++ + LE L+ +A+ E+ + +
Sbjct: 1521 HELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQS 1580
Query: 353 LLLQEKYDSMVQSLEDVTAQFE---SYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQ 409
+EK +V+ + ++ A+ E +++ + + L+++ L+ A KN ++
Sbjct: 1581 ---EEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAI 1637
Query: 410 HQILATESSNQEYVRMLLD---------LQTKSALKETEIKEITVSFLQKITDLQNQLKQ 460
Q+ ++ ++ +R L D Q K K+ + E + LQ+ + K+
Sbjct: 1638 KQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKR 1697
Query: 461 QEEDFRKQLEDEEGRKAEK-----------ENTTAELTEEINKWRLLYEELYNKTKPFQL 509
Q + R +L DE + K E A+L EE+ + + E + ++ K L
Sbjct: 1698 QAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANL 1757
Query: 510 QLDAFEVE-----KQALLNEHGAAQ-EQLNK-IRDSYAKLLGHQNLKQKIKHV---VKLK 559
Q+D + A NE+ Q E+ NK ++ ++ G K K K+
Sbjct: 1758 QIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIA 1817
Query: 560 DENSQLKSEVSKLRCQLAKKKQSETKLQEELNKV 593
QL +E + + + +++E KL++ L +V
Sbjct: 1818 QLEEQLDNETKERQAACKQVRRTEKKLKDVLLQV 1851
Score = 100 bits (250), Expect = 3e-21
Identities = 138/596 (23%), Positives = 252/596 (42%), Gaps = 93/596 (15%)
Query: 21 DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRIL 80
DLE +E+ E R EK + N LE+QL E E+ QK
Sbjct: 919 DLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEE------------EESARQK----- 961
Query: 81 SLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDE 140
L+L K+ + + K KL+ Q LE+ K+A+ E KL+ +++I E
Sbjct: 962 -LQLEKVTTEAKLK-------------KLEEEQIILEDQNCKLAK-EKKLL---EDRIAE 1003
Query: 141 KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLK---EKNDEILSLKQSLEENIVILS 197
T L E E+ + K++ I LEE L+ ++ E+ ++ LE + LS
Sbjct: 1004 --FTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLS 1061
Query: 198 KQVEDL-----NVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK 252
Q+ +L +K QL +KE+E L A + ++++ + +K+++
Sbjct: 1062 DQIAELQAQIAELKMQLAKKEEE------------LQAALARVEEEAAQKNMALKKIREL 1109
Query: 253 ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDEL---DKLQQKEEQA 309
E QI S LQ++ E + K + ++ +E + EL+ TLD +L+ K EQ
Sbjct: 1110 ESQI-SELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQE 1168
Query: 310 ERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDV 369
++K K LEE+ K EA++++ H+QA E+ ++ + V
Sbjct: 1169 VNILK-------------KTLEEEAKTHEAQIQEMRQKHSQAV----EELAEQLEQTKRV 1211
Query: 370 TAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDL 429
A E K +E +L E L + + + V+ Q+ + E R+ +L
Sbjct: 1212 KANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTEL 1271
Query: 430 QTKSALKETEIKEITVSFLQ------KITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTT 483
K + E+ +T Q K+T + L+ Q +D ++ L++E +K
Sbjct: 1272 ADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKL 1331
Query: 484 AELTEEINKWRLLYEELYNKTKPFQLQLDAFEVE----KQALLNEHG---AAQEQLNKIR 536
++ +E N +R EE + Q+ + K+ + + G A+E K++
Sbjct: 1332 KQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ 1391
Query: 537 DSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNK 592
L Q ++K+ KL+ ++L+ E+ L L ++QS L+++ K
Sbjct: 1392 KDLEGL--SQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKK 1445
Score = 95.5 bits (236), Expect = 1e-19
Identities = 109/547 (19%), Positives = 245/547 (44%), Gaps = 49/547 (8%)
Query: 109 LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDI 168
LQV+++ EE K E +LV + ++++ ++ ++ ++ Q+++
Sbjct: 838 LQVSRQE-EEMMAK----EEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE 892
Query: 169 AQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENL 228
+L +E + + KQ LEE L +VE+ +CQ L+ EK+ +
Sbjct: 893 TELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKK-----------KM 941
Query: 229 NAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLF 288
+Q L+++ E+ R+KLQ +++ ++ L++ +E L + C ++ KEK L
Sbjct: 942 QQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNC----KLAKEKKLL 997
Query: 289 EEELKQTLDELDKLQQK-------EEQAERLVKQLEEEAK---SRAEELKLLEEKLKGKE 338
E+ + + L + ++K + + E ++ LEE + + +EL+ KL+G
Sbjct: 998 EDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057
Query: 339 AELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFE---SYKALTASEIEDLKLENSSLQ 395
+L A L+ + + L+ A+ E + K + +I +L+ + S LQ
Sbjct: 1058 TDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQ 1117
Query: 396 E--KAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 453
E ++ +A +N + Q + L E E ++ L+ S + E++ Q++
Sbjct: 1118 EDLESERASRNKAEKQKRDLGEE---LEALKTELEDTLDSTAAQQELRS---KREQEVNI 1171
Query: 454 LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA 513
L+ L+++ + Q+++ + + EL E++ + + + L + + +
Sbjct: 1172 LKKTLEEEAKTHEAQIQE---MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGE 1228
Query: 514 FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR 573
E + LL G ++ + K+ +L N ++++ +L D+ ++L+ E+ +
Sbjct: 1229 LANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVR--TELADKVTKLQVELDNVT 1286
Query: 574 CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLK--EGNTNCYRAPM 631
L++ +KL ++ + L + D + E+++ +L T LK E N +R +
Sbjct: 1287 GLLSQSDSKSSKLTKDFS-ALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQL 1345
Query: 632 ECQESWK 638
E +E K
Sbjct: 1346 EEEEEAK 1352
Score = 92.0 bits (227), Expect = 1e-18
Identities = 122/546 (22%), Positives = 251/546 (45%), Gaps = 86/546 (15%)
Query: 98 MMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEK--SETEKLLEYIE--- 152
MMAK+E + +K++ Q + E ++ L+ +L++ EK ++ E+ +ETE E E
Sbjct: 847 MMAKEEEL-VKVREKQLAAENRLTEMETLQSQLMA-EKLQLQEQLQAETELCAEAEELRA 904
Query: 153 EISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK 212
++ ++E+ D+ E +E+ + + K+ +++NI L +Q+E+ Q L+
Sbjct: 905 RLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQL 964
Query: 213 EK-EDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSL- 270
EK + E + E QN K +E++ L+ + + + L +E+E S SL
Sbjct: 965 EKVTTEAKLKKLEEEQIILEDQNCKL-----AKEKKLLEDRIAEFTTNLTEEEEKSKSLA 1019
Query: 271 -----HQKLCSFQEEMVKEKNLFEEELKQTLDELD----------------------KLQ 303
H+ + + EE ++ + +EL++T +L+ +L
Sbjct: 1020 KLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLA 1079
Query: 304 QKEEQAERLVKQLEEEAKSR---AEELKLLEEKLKGKEAELEKSSAAHTQATLL---LQE 357
+KEE+ + + ++EEEA + ++++ LE ++ + +LE A+ +A L E
Sbjct: 1080 KKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGE 1139
Query: 358 KYDSMVQSLEDV---TAQFESYKALTASEI--------EDLKLENSSLQEKAAKAGKNAE 406
+ +++ LED TA + ++ E+ E+ K + +QE K + E
Sbjct: 1140 ELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVE 1199
Query: 407 DVQHQILATE--SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEED 464
++ Q+ T+ +N E + L+ + E ++ LQ D +++ K+ E
Sbjct: 1200 ELAEQLEQTKRVKANLEKAKQTLENERGELANEVKV------LLQGKGDSEHKRKKVE-- 1251
Query: 465 FRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNE 524
QL++ + + E E EL +++ K L EL N T L + + L +
Sbjct: 1252 --AQLQELQVKFNEGERVRTELADKVTK---LQVELDNVTG----LLSQSDSKSSKLTKD 1302
Query: 525 HGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSET 584
A + QL ++ LL +N +QK+ KLK Q++ E + R QL ++++++
Sbjct: 1303 FSALESQLQDTQE----LLQEEN-RQKLSLSTKLK----QVEDEKNSFREQLEEEEEAKH 1353
Query: 585 KLQEEL 590
L++++
Sbjct: 1354 NLEKQI 1359
Score = 62.8 bits (151), Expect = 9e-10
Identities = 91/498 (18%), Positives = 211/498 (42%), Gaps = 62/498 (12%)
Query: 10 QERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFS 69
+ER + ++ ET+ + L A+ +K L N ++ +L + + +
Sbjct: 1462 EERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVH 1521
Query: 70 ENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEG---MEMKLQVTQRSLEES-QGKIAQ 125
E +K+ R L ++ +++ + E + A ++ +E+ LQ + E QG+ Q
Sbjct: 1522 EL--EKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQ 1579
Query: 126 LEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKN---DEI 182
E K + ++ + ++E E + ++ S A +K ++D+ LE ++ N DE
Sbjct: 1580 SEEKKKQLVRQVREMEAELE---DERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEA 1636
Query: 183 LSLKQSLEENIVILSKQVEDLNV-KCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFIL 241
+ + L+ + ++++D + ++L + KE N + +++ AEM L+++
Sbjct: 1637 IKQLRKLQAQMKDCMRELDDTRASREEILAQAKE-----NEKKLKSMEAEMIQLQEELAA 1691
Query: 242 EQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDK 301
++ + + QQ+ ++ E+++S + + +E K E + Q +EL++
Sbjct: 1692 AERAKRQAQQERDELAD------EIANSSGKGALALEE-----KRRLEARIAQLEEELEE 1740
Query: 302 LQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQE---- 357
Q E +K+ + +L L + E ++ + + + LQE
Sbjct: 1741 EQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGT 1800
Query: 358 ---KYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILA 414
KY + + +LE AQ E ++++ E + ++ + K +DV Q+
Sbjct: 1801 VKSKYKASITALEAKIAQLE-------EQLDNETKERQAACKQVRRTEKKLKDVLLQVDD 1853
Query: 415 TESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEG 474
+ ++Y K+ K T ++ L+ QL++ EE+ ++
Sbjct: 1854 ERRNAEQY-------------KDQADKAST-----RLKQLKRQLEEAEEEAQRANASRRK 1895
Query: 475 RKAEKENTTAELTEEINK 492
+ E E+ T E + +N+
Sbjct: 1896 LQRELEDAT-ETADAMNR 1912
Score = 62.8 bits (151), Expect = 9e-10
Identities = 75/402 (18%), Positives = 175/402 (43%), Gaps = 70/402 (17%)
Query: 5 IRVLLQERGAQDRRIQDLETELEKMEARLNAA----LREKTSLSANNATLEKQLI----- 55
+ L + + A ++++++++T+LE++E L A LR + +L A A E+ L
Sbjct: 1520 VHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQ 1579
Query: 56 ------ELTRTNELLKSKFSENGNQKNLRILSL----------------------ELMKL 87
+L R ++++ + Q+++ + + E +K
Sbjct: 1580 SEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQ 1639
Query: 88 RNKRETKMRGMM-------AKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDE 140
K + +M+ M A +E + + + ++ L+ + ++ QL+ +L + E+ K
Sbjct: 1640 LRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQA 1699
Query: 141 KSETEKLLEYIEEIS----CASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVIL 196
+ E ++L + I S A ++ + + IAQLEE L+E+ + L++ + +
Sbjct: 1700 QQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQI 1759
Query: 197 SKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNL----KQKFI------------ 240
+ DLN++ +K + R+ N+ L ++Q + K K+
Sbjct: 1760 DQINTDLNLERSHAQKNENARQQLERQ-NKELKVKLQEMEGTVKSKYKASITALEAKIAQ 1818
Query: 241 LEQQEREKLQQKELQIDSLLQQEKELSSSLHQ-----KLCSFQEEMVKEKNLFEEELKQT 295
LE+Q + ++++ + + EK+L L Q + ++ + + ++LK+
Sbjct: 1819 LEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQ 1878
Query: 296 LDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK 337
L+E ++ Q+ + R +++ E+A A+ + LK K
Sbjct: 1879 LEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNK 1920
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 112 bits (279), Expect = 1e-24
Identities = 158/641 (24%), Positives = 292/641 (45%), Gaps = 95/641 (14%)
Query: 21 DLETELEKMEARLNAALREKTS-LSANNATLEKQLIELTR-TNELLKSKFSENGNQKN-- 76
+LE + K+ A A+L++ S LSA N +L + ++L R +L + K + G Q+
Sbjct: 719 ELELSMTKLRAE-EASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAE 777
Query: 77 ------------LRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA 124
L L LE R E +R QE +E +L + + Q ++A
Sbjct: 778 QEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLA 837
Query: 125 QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEK------YKLDIAQLE-ENLKE 177
QL +L E+E + E ++ +E +E + + + K +L A+ E L E
Sbjct: 838 QLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSE 897
Query: 178 KNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQ 237
+ + K++LE ++ + +Q+ L + + LE E + + E L E+ L+Q
Sbjct: 898 EATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAK----ETLTGELAGLRQ 953
Query: 238 KFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEE---MVKEKNLFEEELKQ 294
+ I+ QE+ L KEL L+Q E+E +SL ++ + +E+ + +EK EL+
Sbjct: 954 Q-IIATQEKASLD-KELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEA 1011
Query: 295 TLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLL----EEKLKGKEAELEKSSAAHTQ 350
+L Q+E+ E L+ +LE E + +EE+ L +E L E+E +++ +
Sbjct: 1012 ERAQLQSQLQREQ--EELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKES 1069
Query: 351 ATLLLQEKYDSMVQSLEDVTAQFESYK---------------ALTASEIEDLKLENSSLQ 395
L EK SL ++ + E K ALT SE+ DL+ + +
Sbjct: 1070 EKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALT-SELRDLRAQ----R 1124
Query: 396 EKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD-L 454
E+AA A +A++V+ QE R L Q S L+E E + L+ D L
Sbjct: 1125 EEAAAA--HAQEVRRL--------QEQARD-LGKQRDSCLREAEELRTQLRLLEDARDGL 1173
Query: 455 QNQLKQQEEDFRKQLEDEEGRKAEKE------NTTAELTEEINKWRLLYEELYNKTKPFQ 508
+ +L + + RK E +EGR+ +++ + E +E R EEL + K +
Sbjct: 1174 RRELLEAQ---RKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAE 1230
Query: 509 LQLDAFEV------EKQALLNE-HGAAQEQLNKIRDSY-----AKLLGHQNLKQKIKHVV 556
+ + ++ +K ALL E A ++ ++R ++L + L++ + +
Sbjct: 1231 SERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMK 1290
Query: 557 KLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIK 597
L EN++L E+++L+ +LA +++E +E + LG++
Sbjct: 1291 MLDSENTRLGRELAELQGRLALGERAE---KESRRETLGLR 1328
Score = 86.7 bits (213), Expect = 6e-17
Identities = 125/560 (22%), Positives = 244/560 (43%), Gaps = 64/560 (11%)
Query: 17 RRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKN 76
R++ LE E++EA A L K +L+ A L +Q+I L K
Sbjct: 918 RQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDK----------- 966
Query: 77 LRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQ-VTQRSLEESQGKIAQLEGKLVSIEK 135
+++ +L++ + + +R A E +LQ + + E + + AQL+ +L E+
Sbjct: 967 -ELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQL-QREQ 1024
Query: 136 EKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQS----LEE 191
E++ + E EK E + E A Q L +A+ E+ + LSLK+S L E
Sbjct: 1025 EELLARLEAEK--EELSEEIAALQQERDEGLLLAESEK------QQALSLKESEKTALSE 1076
Query: 192 NIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNA---EMQNLK----QKFILEQQ 244
++ + ++++ +E++K D +R + +NA E+++L+ + Q
Sbjct: 1077 KLMGTRHSLATISLE---MERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQ 1133
Query: 245 EREKLQQKE----LQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD 300
E +LQ++ Q DS L++ +EL + L +L + ++ + L E + K +
Sbjct: 1134 EVRRLQEQARDLGKQRDSCLREAEELRTQL--RLLEDARDGLR-RELLEAQRKLRESQEG 1190
Query: 301 KLQQKEEQAERLVKQLEEEAKSRA------EELKLLEEKLKGKEAELEKSSAAHTQATLL 354
+ Q++E E L + L E AK R EEL+ +K + + L+ ++ Q L
Sbjct: 1191 REVQRQEAGE-LRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLAL 1249
Query: 355 LQEKYDSMVQSLEDVTA---QFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQ 411
L+E ++ + ++ + E + E+++L+ + L + + G+ ++Q +
Sbjct: 1250 LEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGR 1309
Query: 412 ILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLED 471
+ E + +E R L L+ + E ++ + Q++ Q +L++QE +FR +
Sbjct: 1310 LALGERAEKESRRETLGLRQRLLKGEASLEVMR----QELQVAQRKLQEQEGEFRTRERR 1365
Query: 472 EEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNE------- 524
G E T + + L E + L+L A E Q L E
Sbjct: 1366 LLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQ 1425
Query: 525 HGAAQEQLNKIRDSYAKLLG 544
AA+ QL +R + + LG
Sbjct: 1426 RRAAEAQLGGLRSALRRGLG 1445
Score = 83.6 bits (205), Expect = 5e-16
Identities = 138/649 (21%), Positives = 281/649 (43%), Gaps = 101/649 (15%)
Query: 20 QDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRI 79
Q L+ EL ++E L + E+ L+ + ++L + R L+ E + L
Sbjct: 84 QLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALR----LEPGELETQEPRGLVR 139
Query: 80 LSLELMK-LRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKI 138
S+EL + L+ ++ + R + A QEG + + Q+ QR QGKI Q + + +E++ +
Sbjct: 140 QSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRL----QGKILQYKKRCSELEQQLL 195
Query: 139 DEKSETEKL----LEYIEEISCASDQVEKYK---LDIAQLEENLKEKNDEILSLKQSLEE 191
+ E E+ E+ +++ A ++E+ + +AQ+ L+E+ D+ S Q+L E
Sbjct: 196 ERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSE 255
Query: 192 NIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ------- 244
+I ++V + +C+ KE E R E+ NA N + +L +
Sbjct: 256 DI----RKVTNDWTRCR---KELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRR 308
Query: 245 ---------EREKLQ------------------------QKELQIDSLLQQEKELSSSLH 271
ER+ LQ E + ++ L+++ L + L
Sbjct: 309 LVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLE 368
Query: 272 QKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLE 331
++L ++++++EK+L +++++ LD+ D L + + VK+LE++ + + K L
Sbjct: 369 EQL---RDKVLREKDLAQQQMQSDLDKAD-LSARVTELGLAVKRLEKQNLEKDQVNKDLT 424
Query: 332 EKLKGKEA-ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASE------- 383
EKL+ E+ L++ +A T+ LQ+ + Q+ V + ES L+ SE
Sbjct: 425 EKLEALESLRLQEQAALETEDGEGLQQTLRDLAQA---VLSDSESGVQLSGSERTADASN 481
Query: 384 --IEDLKLENSSLQEKAAKAGKNAEDVQHQILA-TESSNQEYVRMLL---DLQTKSALKE 437
+ L + + + + G+ + A ++SS + L LQ +
Sbjct: 482 GSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGR 541
Query: 438 TEIKEITVSFLQK-ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLL 496
E + + L+K ++D +++ + EE ++ + +G E+ E+ + LL
Sbjct: 542 YEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELL 601
Query: 497 YEELYNKTKPFQL---QLDAFEVEKQALLNEHGAAQEQLNKIRDSYAK---------LLG 544
E N Q+ Q + E++ L AAQE+L + RD +
Sbjct: 602 SREKSNLAHSLQVAQQQAEELRQEREKL----QAAQEELRRQRDRLEEEQEDAVQDGARV 657
Query: 545 HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKV 593
+ L++ + + +L+ + S L E+ ++R L++ LQ E +V
Sbjct: 658 RRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEV 706
Score = 77.8 bits (190), Expect = 3e-14
Identities = 122/613 (19%), Positives = 254/613 (41%), Gaps = 68/613 (11%)
Query: 4 LIRVLLQERGAQDRRIQDLETELEKMEARLNAA--LREKTSLSANNATLEKQLIELTRTN 61
L++ L+E+ +D+ +++ + ++M++ L+ A T L LEKQ +E + N
Sbjct: 362 LLQAQLEEQ-LRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVN 420
Query: 62 ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVT--QRSLEES 119
+ L K + + +LE ++T A E +Q++ +R+ + S
Sbjct: 421 KDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADAS 480
Query: 120 QGKIAQLEGKLVSIEKEKIDE------KSETEKLLEYIEEISCASDQVEKYKLDIAQLEE 173
G + L G+ + + ++ + K +L + +
Sbjct: 481 NGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRG 540
Query: 174 NLKEKNDEILSLKQSL---EENIVILSKQVEDLNVKCQLLEKEKED---HVNRNREHNEN 227
+ D + +L++ L E L +Q++ L K + ED V R R NE
Sbjct: 541 RYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANEL 600
Query: 228 LNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNL 287
L+ E NL + QQ+ E+L+Q+ +KL + QEE+ ++++
Sbjct: 601 LSREKSNLAHSLQVAQQQAEELRQER------------------EKLQAAQEELRRQRDR 642
Query: 288 FEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAA 347
EEE + + + +++++ E++ R ++QLE + A+EL + E L S A
Sbjct: 643 LEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREAL----------SRA 692
Query: 348 HTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLEN-----SSLQEKAAKAG 402
Q +L EK + + + E ++T E+ L++ S+L E A+
Sbjct: 693 TLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDK 752
Query: 403 KNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLK--- 459
+ + Q+ +S+ Q R T + ++ ++E+ + L+ L+
Sbjct: 753 LDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAE 812
Query: 460 QQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFE---V 516
Q +E +QL +++ + A+L+ +++ +EL + Q Q++A E
Sbjct: 813 QAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGRE---QELEQARREAQRQVEALERAAR 869
Query: 517 EKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQL 576
EK+AL EH QL + + + + +L+ E L+ + +++ QL
Sbjct: 870 EKEALAKEHAGLAVQL---------VAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQL 920
Query: 577 AKKKQSETKLQEE 589
A+ + +L+ E
Sbjct: 921 AQLEARREQLEAE 933
Score = 69.3 bits (168), Expect = 1e-11
Identities = 109/520 (20%), Positives = 222/520 (42%), Gaps = 60/520 (11%)
Query: 26 LEKMEARLNAALREKTSLSANNATLEKQLIEL--------TRTNELLK-------SKFSE 70
L + L +A RE+ L + L +QL E+ +R +L K ++ S
Sbjct: 1511 LREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSV 1570
Query: 71 NGNQKNLRI-LSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGK 129
+G ++ L+L+ +R + E + R + + +E LQ T+ L SQ KI++++
Sbjct: 1571 DGRLSGVQAELALQEESVR-RSERERRATLDQVATLERSLQATESELRASQEKISKMKAN 1629
Query: 130 LVSIEKEK-----IDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 184
+E +K + + SE+ + ++ S ++++ +L ++ E + D + S
Sbjct: 1630 ETKLEGDKRRLKEVLDASESRTVKLELQRRS-LEGELQRSRLGLSDREAQAQALQDRVDS 1688
Query: 185 LKQSLEENIV---ILSKQVEDLN---VKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQK 238
L++ + ++ V L VE LN K + E D V E +A + + + K
Sbjct: 1689 LQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDK 1748
Query: 239 FILEQQ-------EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVK---EKNLF 288
+ Q+ +R+ LQ++ L + ++ SSSL +++ + + E+ ++
Sbjct: 1749 NLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEA 1808
Query: 289 EEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAH 348
E +L+Q + L + Q+ E A V++L++E + E L L+ L A+LE
Sbjct: 1809 EGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRAL----AQLEAEKREV 1864
Query: 349 TQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDV 408
++ L L++ ++ ++L+ V E K + + L E L A +
Sbjct: 1865 ERSALRLEKDRVALRRTLDKV----EREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEA 1920
Query: 409 QHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQ 468
Q QI E+ ++L+ A E + ++ + Q++ L++ Q E
Sbjct: 1921 QRQIQQLEAQ-----VVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTL--- 1972
Query: 469 LEDEEGRKAEKENTTAELTEEINKWR-LLYEELYNKTKPF 507
E R+ L E+++ + L +EL + PF
Sbjct: 1973 ----EARERAHRQRVRGLEEQVSTLKGQLQQELRRSSAPF 2008
Score = 69.3 bits (168), Expect = 1e-11
Identities = 87/450 (19%), Positives = 196/450 (43%), Gaps = 18/450 (4%)
Query: 10 QERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFS 69
+ R + D R+ ++ EL E + + RE+ + ATLE+ L + K S
Sbjct: 1565 EARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKIS 1624
Query: 70 E-NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEG 128
+ N+ L L ++ + E++ + ++ +E +LQ ++ L + + + L+
Sbjct: 1625 KMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQD 1684
Query: 129 KLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQS 188
++ S++++ D + + L +E ++ A +VE+ + + L E + + S
Sbjct: 1685 RVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNS 1744
Query: 189 LEENIVILSKQVEDLNVKCQLLEKEKE---DHVNRNREHNENLNAEMQNLKQKFILEQQE 245
+ + L K + Q+L++ + ++ R+ + +L ++Q L+ + + +
Sbjct: 1745 TRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQ 1804
Query: 246 REKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQK 305
R + + + Q+ +L+Q +E ++ + Q+ E+ L +E L L +L+ +
Sbjct: 1805 RVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQD----ERRLLQERLGSLQRALAQLEAE 1860
Query: 306 EEQAERLVKQLEEEAKSRAEEL-KLLEEKLKGKE------AELEKSSAAHTQATLLLQEK 358
+ + ER +LE++ + L K+ EKL+ E AE + T A L L E
Sbjct: 1861 KREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEA 1920
Query: 359 YDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESS 418
+Q LE E + E+ D + + LQ++ + + + A E +
Sbjct: 1921 -QRQIQQLEAQVVVLEQSHSPAQLEV-DAQQQQLELQQEVERLRSAQAQTERTLEARERA 1978
Query: 419 NQEYVRMLLD-LQTKSALKETEIKEITVSF 447
+++ VR L + + T + E++ + F
Sbjct: 1979 HRQRVRGLEEQVSTLKGQLQQELRRSSAPF 2008
Score = 45.4 bits (106), Expect = 2e-04
Identities = 73/349 (20%), Positives = 151/349 (43%), Gaps = 56/349 (16%)
Query: 243 QQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKL 302
Q+E + LQQ+ +++ LL Q + + ++E+ + N E L+Q L L+
Sbjct: 80 QEENQLLQQELSRVEDLLAQSR-----------AERDELAIKYNAVSERLEQAL-RLEPG 127
Query: 303 QQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSM 362
+ + ++ LV+Q E L +L+ ++A + A+ + Q++ +
Sbjct: 128 ELETQEPRGLVRQSVE-----------LRRQLQEEQASYRRKLQAYQEG----QQRQAQL 172
Query: 363 VQSLEDVTAQFESYKALTASEIEDLKLENS-SLQEKAAKAGKNAEDVQHQILATESSNQE 421
VQ L+ Q++ SE+E LE S L+++ + ++++D++ ++ E Q
Sbjct: 173 VQRLQGKILQYKK----RCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQR 228
Query: 422 ---------YVRMLLDL--QTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLE 470
+R LD AL E +I+++T + T + +L+ +E +R++ E
Sbjct: 229 SASLAQVNAMLREQLDQAGSANQALSE-DIRKVTNDW----TRCRKELEHREAAWRREEE 283
Query: 471 DEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE 530
+ + + L ++ +R L E+ T+ LQL + E G
Sbjct: 284 SFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLS 343
Query: 531 QLNKIRDSYAK-------LLGHQNLKQKIKHVVKLKD-ENSQLKSEVSK 571
++ +S A+ LL Q +Q V++ KD Q++S++ K
Sbjct: 344 TGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDK 392
Score = 43.1 bits (100), Expect = 8e-04
Identities = 79/381 (20%), Positives = 153/381 (40%), Gaps = 31/381 (8%)
Query: 222 REHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSS--LHQKLCSFQE 279
+E N+ L E+ ++ + ER++L K + L+Q L Q+
Sbjct: 80 QEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLVR 139
Query: 280 EMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA 339
+ V+ + +EE +L Q+ +++ +LV++L+ + + LE++L +
Sbjct: 140 QSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSG 199
Query: 340 ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAA 399
ELE+ T+ + Q LE + E + +AS L N+ L+E+
Sbjct: 200 ELEQQRLRDTEHS-----------QDLESALIRLEEEQQRSAS----LAQVNAMLREQLD 244
Query: 400 KAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLK 459
+AG + + I ++ R +L+ + A E + F + + L L
Sbjct: 245 QAGSANQALSEDI---RKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLL-LLW 300
Query: 460 QQEEDFRKQLEDEEGRKAEKENTTAELTEEINKW-RLLYEELYNKTKPFQLQLDAFE--V 516
+Q FR+ + + K E +L E+ + R + E + +L E +
Sbjct: 301 RQVVGFRRLVSEV---KMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAAL 357
Query: 517 EKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQL 576
EKQALL Q + +R+ K L Q ++ + L ++L V +L Q
Sbjct: 358 EKQALLQAQLEEQLRDKVLRE---KDLAQQQMQSDLDK-ADLSARVTELGLAVKRLEKQN 413
Query: 577 AKKKQSETKLQEELNKVLGIK 597
+K Q L E+L + ++
Sbjct: 414 LEKDQVNKDLTEKLEALESLR 434
Score = 42.0 bits (97), Expect = 0.002
Identities = 74/335 (22%), Positives = 136/335 (40%), Gaps = 42/335 (12%)
Query: 288 FEEELKQTLDELDKLQQKEEQAERLVKQLEEE---AKSRAEELKLLEEKLKGKEAELEKS 344
F +EL+ E D+L+ + R + ++E E A SRA +L +K + E +S
Sbjct: 1514 FLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQL----QKAVAESEEARRS 1569
Query: 345 ---SAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKA 401
+ QA L LQE +S+ +S + A + L S ++ + E + QEK +K
Sbjct: 1570 VDGRLSGVQAELALQE--ESVRRSERERRATLDQVATLERS-LQATESELRASQEKISKM 1626
Query: 402 GKNAEDVQ--HQILATESSNQEYVRMLLDLQTKSALKETEIKEITVS--------FLQKI 451
N ++ + L E + L+LQ +S E + + +S ++
Sbjct: 1627 KANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRV 1686
Query: 452 TDLQNQLKQQE----------EDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELY 501
LQ Q+ E E L E + + LTE + +
Sbjct: 1687 DSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTR 1746
Query: 502 NKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDE 561
+K Q L A E ++Q L AA++ L++ R + L + ++ V L+ +
Sbjct: 1747 DKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSL--GEQVQTLRGEVADLELQ 1804
Query: 562 NSQLKSEVSKLRCQLAKKKQSET-------KLQEE 589
+ + ++ +LR L ++++ E KLQ+E
Sbjct: 1805 RVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDE 1839
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 111 bits (278), Expect = 2e-24
Identities = 152/671 (22%), Positives = 284/671 (42%), Gaps = 105/671 (15%)
Query: 21 DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRT-NELLKSKFSENGNQKNLRI 79
+ E E+ M+ E A LE++++ L + N+L SE + +
Sbjct: 847 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEE 906
Query: 80 LSLELMKLRNKRETKMRGMMAK---QEGMEMKLQVTQRSLE----ESQGKIAQLEGKLVS 132
+L+K + + E K++ + + +E + +L +R LE E + I LE L
Sbjct: 907 RCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 966
Query: 133 IEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEEN 192
+EKEK +++ + L E E++ + + K + L+E ++ D++ Q+ E+
Sbjct: 967 VEKEKHATENKVKNLTE---EMAGLDETIAKLSKEKKALQETHQQTLDDL----QAEEDK 1019
Query: 193 IVILSK-------QVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQE 245
+ IL+K QV+DL + +K + D R+ +L ++ +QQ
Sbjct: 1020 VNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQL 1079
Query: 246 REKLQQKELQIDSLL---QQEKELSSSLHQKLCSFQ-------EEMVKEKNLFEEELKQT 295
EKL++KE +I +L+ + E+ + L +K+ Q EE+ E+ + KQ
Sbjct: 1080 DEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQR 1139
Query: 296 LD---ELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQAT 352
D EL+++ ++ E+A E K R E + L +LE+++ H
Sbjct: 1140 SDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRR-------DLEEATLQHEAMV 1192
Query: 353 LLLQEKY-DSM------VQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNA 405
L++K+ DSM + +L+ V + E K+ E +DL ++ + K
Sbjct: 1193 AALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMC 1252
Query: 406 EDVQHQILATESSNQEYVRMLLDLQTKSALKETEI---------KEITVSFL-------- 448
++ Q+ ++ +E R++ DL + A +TE K+ VS L
Sbjct: 1253 RSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAST 1312
Query: 449 QKITDLQNQLKQQEED-----------------FRKQLEDEEGRKAEKENTTAELTEEIN 491
Q+I +L++QL+++ + R+Q E+E+ KAE + ++ E+
Sbjct: 1313 QQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA 1372
Query: 492 KWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQK 551
+WR YE T Q + + E K+ L A+E + + AK + KQ+
Sbjct: 1373 QWRTKYE-----TDAIQ-RTEELEEAKKKLAQRLQEAEEHVEAVN---AKCASLEKTKQR 1423
Query: 552 IKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLG---IKHFDPSKAFHHE 608
+++ V E+ L E S C KK Q +KVL K+ +
Sbjct: 1424 LQNEV----EDLMLDVERSNAACAALDKK------QRNFDKVLSEWKQKYEETQAELEAS 1473
Query: 609 SKENFALKTPL 619
KE+ +L T L
Sbjct: 1474 QKESRSLSTEL 1484
Score = 108 bits (269), Expect = 2e-23
Identities = 137/637 (21%), Positives = 280/637 (43%), Gaps = 50/637 (7%)
Query: 1 MTLLIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRT 60
+T R L E + I DLE L K+E +A + +L+ A L++ + +L++
Sbjct: 939 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKE 998
Query: 61 NELLKSKFSE-----NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRS 115
+ L+ + + + IL+ KL + + + G + +++ + M L+ +R
Sbjct: 999 KKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVD-DLEGSLEQEKKLRMDLERAKRK 1057
Query: 116 LEESQGKIAQLEGKLVSIEKEKIDEKSETEK-----LLEYIEEISCASDQVEKYKLDIAQ 170
L E K+AQ + +K+++DEK E ++ L+ IE+ Q++K I +
Sbjct: 1058 L-EGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQK---KIKE 1113
Query: 171 LEENLKEKNDEILSLKQS---LEENIVILSKQVEDLNVKCQ----------LLEKEKEDH 217
L+ ++E +EI + + S E+ LS+++E+++ + + L K++E
Sbjct: 1114 LQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAE 1173
Query: 218 VNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSL------LQQEKELSSSLH 271
+ R E A +Q+ L ++ + + + QID+L L++EK
Sbjct: 1174 FQKLRRDLE--EATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMET 1231
Query: 272 QKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLE 331
L S E + K K E+ + D++ +L+ KEE+ +RL+ L + E
Sbjct: 1232 DDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYS 1291
Query: 332 EKLKGKEA---ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYK---ALTASEIE 385
+L K+A +L +S A TQ L+ + + ++ + +S + L + E
Sbjct: 1292 RQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYE 1351
Query: 386 DLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITV 445
+ + + LQ +KA N+E Q + E+ + L + + K A + E +E
Sbjct: 1352 EEQEGKAELQRALSKA--NSEVAQWR-TKYETDAIQRTEELEEAKKKLAQRLQEAEEHVE 1408
Query: 446 SFLQKITDLQ---NQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYN 502
+ K L+ +L+ + ED +E A + + +++W+ YEE
Sbjct: 1409 AVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQA 1468
Query: 503 KTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGH-QNLKQKIKHVVKLKDE 561
+ + Q + + E + N + + +QL +R L +L ++I K E
Sbjct: 1469 ELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHE 1528
Query: 562 NSQLKSEVSKLRCQL-AKKKQSETKLQEELNKVLGIK 597
++K +V + +C++ A +++E L+ E K+L I+
Sbjct: 1529 LEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQ 1565
Score = 88.2 bits (217), Expect = 2e-17
Identities = 119/513 (23%), Positives = 227/513 (44%), Gaps = 68/513 (13%)
Query: 11 ERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSE 70
E A + + L TEL K++ +L + +L N L++++ +LT + +E
Sbjct: 1469 ELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTE-------QIAE 1521
Query: 71 NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKL 130
G Q + EL K++ + E QE E+ Q +LEE++ + EGK+
Sbjct: 1522 GGKQIH------ELEKIKKQVE---------QEKCEI-----QAALEEAEASLEHEEGKI 1561
Query: 131 VSIEKEKIDEKSETE-KLLEYIEEISCASDQVEKYKLDIAQ-----LEENLKEKNDEILS 184
+ I+ E KSE + K+ E EEI DQ+++ + + L+ ++ +ND L
Sbjct: 1562 LRIQLELNQVKSEVDRKIAEKDEEI----DQLKRNHTRVVETMQSTLDAEIRSRND-ALR 1616
Query: 185 LKQSLEENIVILSKQVEDLN----------VKCQLLEKEKEDHVNRNREHNENLNAEMQN 234
+K+ +E ++ + Q+ N Q + KE + H++ E+L ++
Sbjct: 1617 VKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAI 1676
Query: 235 LKQKFILEQQEREKLQQKELQID---SLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEE 291
++++ L Q E E+L Q + + +QE +S Q L + ++ K E +
Sbjct: 1677 VERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLEND 1736
Query: 292 LKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQA 351
+ Q E++++ Q+ AE K+ +A AEELK K + A LE+ Q
Sbjct: 1737 VSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELK----KEQDTSAHLERMKKNLEQT 1792
Query: 352 TLLLQEKYDSMVQ-SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQH 410
LQ + D Q +L+ Q + +A + +L+ E + Q++ A+A K +
Sbjct: 1793 VKDLQHRLDEAEQLALKGGKKQIQKLEA----RVRELEGEVENEQKRNAEAVKGLRKHER 1848
Query: 411 QILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLE 470
++ +E + +L LQ + ++K S+ ++ + + Q FRK
Sbjct: 1849 RVKELTYQTEEDRKNVLRLQDLVDKLQAKVK----SYKRQAEEAEEQSNANLSKFRKLQH 1904
Query: 471 DEEGRKAEKENTTAELTEEINKWRLLYEELYNK 503
+ E +AE+ AE ++NK R+ E++ K
Sbjct: 1905 ELE--EAEERADIAE--SQVNKLRVKSREVHTK 1933
Score = 80.1 bits (196), Expect = 6e-15
Identities = 138/619 (22%), Positives = 255/619 (41%), Gaps = 111/619 (17%)
Query: 17 RRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENG---- 72
+R ++LE +K+ RL A +++A A+LEK L E L +
Sbjct: 1384 QRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACA 1443
Query: 73 ----NQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEG 128
Q+N + E + + + ++ + + +L + EES + QLE
Sbjct: 1444 ALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEES---LDQLE- 1499
Query: 129 KLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQS 188
++ +E + + E L E I E ++EK K Q+E+ E + + S
Sbjct: 1500 ---TLRRENKNLQQEISDLTEQIAEGGKQIHELEKIK---KQVEQEKCEIQAALEEAEAS 1553
Query: 189 LE-ENIVILSKQVEDLNVKCQ----LLEKEKE-DHVNRNREH-----NENLNAEMQNLKQ 237
LE E IL Q+E VK + + EK++E D + RN L+AE+++
Sbjct: 1554 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRND 1613
Query: 238 KFILEQQEREKLQQKELQID--SLLQQE------------KELSSSLHQKLCSFQEEMVK 283
++++ L + E+Q++ + L E KE L L QE++ +
Sbjct: 1614 ALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRG-QEDLKE 1672
Query: 284 EKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEK 343
+ + E E+++L EQ ER K E+E +E ++LL
Sbjct: 1673 QLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLL------------- 1719
Query: 344 SSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGK 403
HTQ T L+ K + LE+ +Q + SE+E++ E+ + +EKA KA
Sbjct: 1720 ----HTQNTSLINTK-----KKLENDVSQLQ-------SEVEEVIQESRNAEEKAKKAIT 1763
Query: 404 NAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQL----- 458
+A + ++ + ++ RM +L E TV LQ D QL
Sbjct: 1764 DAAMMAEELKKEQDTSAHLERMKKNL------------EQTVKDLQHRLDEAEQLALKGG 1811
Query: 459 KQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKP-------FQLQL 511
K+Q + ++ + EG ++ AE + + K +EL +T+ Q +
Sbjct: 1812 KKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLV 1871
Query: 512 DAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL-KSEVS 570
D + + ++ + A+EQ N + +K++H ++ +E + + +S+V+
Sbjct: 1872 DKLQAKVKSYKRQAEEAEEQSNANLSKF----------RKLQHELEEAEERADIAESQVN 1921
Query: 571 KLRCQLAKKKQSETKLQEE 589
KLR K ++ TK+ E
Sbjct: 1922 KLR---VKSREVHTKISAE 1937
Score = 47.8 bits (112), Expect = 3e-05
Identities = 65/326 (19%), Positives = 130/326 (39%), Gaps = 57/326 (17%)
Query: 305 KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 364
K + E+ + ++EE + +EL E K K E ++ L +Q + DS+
Sbjct: 844 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLAD 903
Query: 365 S-----------------LEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAED 407
+ +++VT + E + + A +L + L+++ ++ K+ +D
Sbjct: 904 AEERCEQLIKNKIQLEAKIKEVTERAEEEEEINA----ELTAKKRKLEDECSELKKDIDD 959
Query: 408 -------VQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQ----- 455
V+ + ATE+ + + L A E K + + Q + DLQ
Sbjct: 960 LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDK 1019
Query: 456 --------NQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPF 507
+L+QQ +D LE E+ + + E +L ++ + ++ N +
Sbjct: 1020 VNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQL 1079
Query: 508 QLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKS 567
+L+ E E L ++KI D A + L++KIK +L+ +L
Sbjct: 1080 DEKLEKKEFEISNL----------ISKIEDEQAVEI---QLQKKIK---ELQARIEELGE 1123
Query: 568 EVSKLRCQLAKKKQSETKLQEELNKV 593
E+ R AK ++ + L EL ++
Sbjct: 1124 EIEAERASRAKAEKQRSDLSRELEEI 1149
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 111 bits (277), Expect = 2e-24
Identities = 143/627 (22%), Positives = 276/627 (44%), Gaps = 69/627 (11%)
Query: 5 IRVLLQERGAQDRRIQDLETELEKMEARLNAALR---EKTSLSANNATLEKQLIELTRTN 61
+++ ++ A ++ +LE E K++ L++ + SL N+ L+++ +EL R
Sbjct: 651 LKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV 710
Query: 62 ELLKS----------KFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQV 111
E LK + E ++K LEL+K K+ ++ +G++++ Q
Sbjct: 711 ESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLE---VSYQGLDIENQR 767
Query: 112 TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQL 171
Q++LE S KI QLE +L +E E +K LE ++ S +Q+EK + Q
Sbjct: 768 LQKTLENSNKKIQQLESELQDLEM----ENQTLQKNLEELKISSKRLEQLEKENKSLEQE 823
Query: 172 EENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAE 231
L++ ++ + L + I +E+ NVK LEKE N+ L+ E
Sbjct: 824 TSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE-----------NKTLSKE 872
Query: 232 MQNLKQKFI----LEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNL 287
+ K+ + LE++ +E +++ + I +L+ ++L S +KL + ++M +
Sbjct: 873 IGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVS---EKLKT--QQMNNDLEK 927
Query: 288 FEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEE-LKLLEEKLKGKEAELEKSSA 346
EL++ ++L E+ + K LE + +S ++ L++ EEK+ EA LE+S+
Sbjct: 928 LTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTN 987
Query: 347 AHTQATLLL---QEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQ--EKAAKA 401
+ Q L ++ Y+++ Q +D +S ++ ED K E S + + K
Sbjct: 988 YNQQLRQELKTVKKNYEALKQR-QDEERMVQSSPPISG---EDNKWERESQETTRELLKV 1043
Query: 402 GKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEI---TVSFLQKITDLQNQ- 457
+V+ ++ Q L L+T++ + +I + TVS ++ T LQ Q
Sbjct: 1044 KDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQN 1103
Query: 458 ---------LKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQ 508
L Q Q +++ EN + +E + LY+ L + +
Sbjct: 1104 AKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLE 1163
Query: 509 LQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSE 568
L + E ++L+++HG + + + L N Q +K +L+D LK E
Sbjct: 1164 LLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYN--QLLKQKGQLEDLEKMLKVE 1221
Query: 569 VSKLRCQLAKKKQSETKLQEELNKVLG 595
K+ L + K ET + E K+ G
Sbjct: 1222 QEKM---LLENKNHET-VAAEYKKLCG 1244
Score = 110 bits (276), Expect = 3e-24
Identities = 156/652 (23%), Positives = 302/652 (46%), Gaps = 91/652 (13%)
Query: 5 IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSL--SANNATLEKQLIELTRTNE 62
IR L QE + ++ D + ELE+ME L +E +L A +A + + ++ R
Sbjct: 260 IRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKA 319
Query: 63 LLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGM-EMKLQVTQR---SLEE 118
+ K ++ R+ +E K R + + ++ + + M E +L+ T+ L E
Sbjct: 320 VRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHE 379
Query: 119 SQGKIAQLEGKLVSIEKEKIDEKSETEKLLE---------------------YIEEISCA 157
+ + QL+ KL +E E+ ++ + E+L+E +E+IS
Sbjct: 380 LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRT 439
Query: 158 SDQVEKYK---------------LDIAQLEENLKEKNDEILSLKQSLEEN---IVILSKQ 199
S+ E + L + ++L + +E+ + S+E N I+ + K+
Sbjct: 440 SELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKE 499
Query: 200 VEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSL 259
+ L+ K ++LE E ++ ++ +NL+ ++ +K+K LE+ + E QI L
Sbjct: 500 NQRLSKKVEILENEIVQE-KQSLQNCQNLSKDL--MKEKAQLEKTIETLRENSERQIKIL 556
Query: 260 LQQEKELS---SSLHQKLCSFQEEMV----KEKNLFEEELKQTLDELDKLQQKEEQAERL 312
Q+ + L+ SSL Q+ E V KE + E +K+T +L K++ ++ Q ++
Sbjct: 557 EQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKE 616
Query: 313 VKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATL----LLQEKYDSMVQSLED 368
++ +E+ + RAEEL+ L+ KE EL + + + T L+++ + +
Sbjct: 617 LEHYKEKGE-RAEELENELHHLE-KENELLQKKITNLKITCEKIEALEQENSELERENRK 674
Query: 369 VTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDV--------QHQILATE-SSN 419
+ +S+K LT ++E L+ ENS L E+ + +N E + Q Q+ E S
Sbjct: 675 LKKTLDSFKNLT-FQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESE 733
Query: 420 QEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQ-LKQQEEDFRKQLE--DEEGRK 476
+E ++ L+L K++ K+TE E++ L D++NQ L++ E+ K+++ + E +
Sbjct: 734 KEQLKKGLEL-LKASFKKTERLEVSYQGL----DIENQRLQKTLENSNKKIQQLESELQD 788
Query: 477 AEKENTTAELT-EEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKI 535
E EN T + EE+ E+L + K + + E +K+ L E+ ++Q +I
Sbjct: 789 LEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA-EI 847
Query: 536 RDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVS--KLRCQLAKKKQSETK 585
+D+ L N+K + L+ EN L E+ K C K+ + E K
Sbjct: 848 KDT---TLEENNVK-----IGNLEKENKTLSKEIGIYKESCVRLKELEKENK 891
Score = 77.0 bits (188), Expect = 5e-14
Identities = 137/628 (21%), Positives = 264/628 (42%), Gaps = 124/628 (19%)
Query: 52 KQLIELTRTNELL--KSKFSENGNQKNLRILSLEL---MKLRNKRE--TKMRGM-MAKQE 103
+QLI ++ N L+ K+ FSE G ++ ++L L L ++ + K E +++G+ +
Sbjct: 95 QQLIMMSLPNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKA 154
Query: 104 GMEMKLQVTQRSLEE------------SQGKIAQLEGKLVSIEKEKIDEKSE-TEKLLEY 150
+ +Q + E SQ I L + K IDE+ E +E ++E
Sbjct: 155 AVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIEL 214
Query: 151 IEEIS---------------CASDQVEKY-------------KLDIAQLEENLKEKNDEI 182
EE C S +++ K I +L + L+EK +++
Sbjct: 215 SEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQL 274
Query: 183 LSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILE 242
L KQ LE + E + R ++ N NL ++ ++ + +
Sbjct: 275 LDCKQELE----------------------QMEIELKRLQQENMNLLSDARSAR----MY 308
Query: 243 QQEREKLQQKELQIDSLLQQEKELSSSLH---------QKLCSFQEEMVKEKNLFEEELK 293
+ E + L++K +++D L + LH ++L + +++ K + E++L+
Sbjct: 309 RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLE 368
Query: 294 QTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATL 353
T DKL + E++ +L +L + R + K +EE L + LE + +L
Sbjct: 369 GTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEE-LMEENMTLEMAQKQSMDESL 427
Query: 354 LLQEKYDSMVQSLEDVTAQFES----YKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQ 409
L + + + ++ E A +S LT+S + L++EN SL + + + V+
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVE 487
Query: 410 ---HQILATESSNQ-----------EYVRMLLDLQ-----TKSALKETEIKEITVSFLQK 450
+IL E NQ E V+ LQ +K +KE E T+ L++
Sbjct: 488 GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Query: 451 ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQ 510
++ Q ++ +QE + Q R+ + + A + + + ++L+E + K +
Sbjct: 548 NSERQIKILEQENEHLNQTVSSL-RQRSQISAEARVKDIEKENKILHESI----KETSSK 602
Query: 511 LDAFEVEKQAL------LNEHGAAQEQL-NKIR--DSYAKLLGHQ--NLKQKIKHVVKLK 559
L E EK+ + E G E+L N++ + +LL + NLK + + L+
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALE 662
Query: 560 DENSQLKSEVSKLRCQLAKKKQSETKLQ 587
ENS+L+ E KL+ L K +L+
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLE 690
Score = 65.9 bits (159), Expect = 1e-10
Identities = 114/517 (22%), Positives = 219/517 (42%), Gaps = 69/517 (13%)
Query: 8 LLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSK 67
L E+ A +++ LET+ ++A++ A R+ SL N TL+ Q +L N L S+
Sbjct: 1057 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1116
Query: 68 FSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLE 127
+ NQ N ++L ++ L N+ E+ ++ L+ SL + K+ L
Sbjct: 1117 STSLMNQ-NAQLL-IQQSSLENENESVIKE--------REDLKSLYDSLIKDHEKLELLH 1166
Query: 128 GKLVSIEKEKIDE----KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEIL 183
+ S + I + KS + L ++ +Q+ K K + LE+ LK + +++L
Sbjct: 1167 ERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKML 1226
Query: 184 SLKQSLEENIVILSKQV----EDLNVKCQLLEKEKE----DH------VNRNREHNENLN 229
L+ E + K++ + LN L KE E DH +N ++ L
Sbjct: 1227 -LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE 1285
Query: 230 AEMQNLKQKFILEQQEREKLQ-QKEL--QIDSLLQQEKELSSSLHQKLC----SFQEEMV 282
AE LK+++ KL Q EL Q+ L++E Q L + E+ +
Sbjct: 1286 AEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNM 1345
Query: 283 KEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELE 342
+ K+LF E +Q +D+L++L++++E+ LEEK+ + +
Sbjct: 1346 ESKDLFHVEQRQYIDKLNELRRQKEK---------------------LEEKIMDQYKFYD 1384
Query: 343 KSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIED----LKLENSSLQEKA 398
S + L K +++S +D+ + + LT + + L+L + Q+ +
Sbjct: 1385 PSPPRRRGNWITL--KMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSS 1442
Query: 399 AKAGKNAEDVQHQILATESSNQEYVRMLLDLQT----KSALKETEIKEITVSFLQKITDL 454
+ + ED Q L T+ S+ ++ L L+ K +K + ++++ L + L
Sbjct: 1443 SVGSNSLED--GQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVL 1500
Query: 455 QNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEIN 491
Q E+ + G++ ++ A T IN
Sbjct: 1501 AGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAIN 1537
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 110 bits (276), Expect = 3e-24
Identities = 156/652 (23%), Positives = 302/652 (46%), Gaps = 91/652 (13%)
Query: 5 IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSL--SANNATLEKQLIELTRTNE 62
IR L QE + ++ D + ELE+ME L +E +L A +A + + ++ R
Sbjct: 260 IRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKA 319
Query: 63 LLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGM-EMKLQVTQR---SLEE 118
+ K ++ R+ +E K R + + ++ + + M E +L+ T+ L E
Sbjct: 320 VRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHE 379
Query: 119 SQGKIAQLEGKLVSIEKEKIDEKSETEKLLE---------------------YIEEISCA 157
+ + QL+ KL +E E+ ++ + E+L+E +E+IS
Sbjct: 380 LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRT 439
Query: 158 SDQVEKYK---------------LDIAQLEENLKEKNDEILSLKQSLEEN---IVILSKQ 199
S+ E + L + ++L + +E+ + S+E N I+ + K+
Sbjct: 440 SELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKE 499
Query: 200 VEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSL 259
+ L+ K ++LE E ++ ++ +NL+ ++ +K+K LE+ + E QI L
Sbjct: 500 NQRLSKKVEILENEIVQE-KQSLQNCQNLSKDL--MKEKAQLEKTIETLRENSERQIKIL 556
Query: 260 LQQEKELS---SSLHQKLCSFQEEMV----KEKNLFEEELKQTLDELDKLQQKEEQAERL 312
Q+ + L+ SSL Q+ E V KE + E +K+T +L K++ ++ Q ++
Sbjct: 557 EQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKE 616
Query: 313 VKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATL----LLQEKYDSMVQSLED 368
++ +E+ + RAEEL+ L+ KE EL + + + T L+++ + +
Sbjct: 617 LEHYKEKGE-RAEELENELHHLE-KENELLQKKITNLKITCEKIEALEQENSELERENRK 674
Query: 369 VTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDV--------QHQILATE-SSN 419
+ +S+K LT ++E L+ ENS L E+ + +N E + Q Q+ E S
Sbjct: 675 LKKTLDSFKNLT-FQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESE 733
Query: 420 QEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQ-LKQQEEDFRKQLE--DEEGRK 476
+E ++ L+L K++ K+TE E++ L D++NQ L++ E+ K+++ + E +
Sbjct: 734 KEQLKKGLEL-LKASFKKTERLEVSYQGL----DIENQRLQKTLENSNKKIQQLESELQD 788
Query: 477 AEKENTTAELT-EEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKI 535
E EN T + EE+ E+L + K + + E +K+ L E+ ++Q +I
Sbjct: 789 LEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA-EI 847
Query: 536 RDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVS--KLRCQLAKKKQSETK 585
+D+ L N+K + L+ EN L E+ K C K+ + E K
Sbjct: 848 KDT---TLEENNVK-----IGNLEKENKTLSKEIGIYKESCVRLKELEKENK 891
Score = 109 bits (273), Expect = 7e-24
Identities = 139/639 (21%), Positives = 276/639 (43%), Gaps = 92/639 (14%)
Query: 5 IRVLLQERGAQDRRIQDLETELEKMEARLNAALR---EKTSLSANNATLEKQLIELTRTN 61
+++ ++ A ++ +LE E K++ L++ + SL N+ L+++ +EL R
Sbjct: 651 LKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV 710
Query: 62 ELLKS----------KFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQV 111
E LK + E ++K LEL+K K+ ++ +G++++ Q
Sbjct: 711 ESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLE---VSYQGLDIENQR 767
Query: 112 TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQL 171
Q++LE S KI QLE +L +E E +K LE ++ S +Q+EK + Q
Sbjct: 768 LQKTLENSNKKIQQLESELQDLEM----ENQTLQKNLEELKISSKRLEQLEKENKSLEQE 823
Query: 172 EENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAE 231
L++ ++ + L + I +E+ NVK LEKE N+ L+ E
Sbjct: 824 TSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE-----------NKTLSKE 872
Query: 232 MQNLKQKFI----LEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNL 287
+ K+ + LE++ +E +++ + I +L+ ++L S E +K + +
Sbjct: 873 IGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVS-----------EKLKTQQM 921
Query: 288 FEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKG---KEAELEKS 344
+L++ EL+K+ +E + L +E + KLLE KL+ K E+++
Sbjct: 922 -NNDLEKLTHELEKIGLNKE------RLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEE 974
Query: 345 SAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENS-SLQEKAAKAGK 403
A +A L Y+ ++ +++ ++Y+AL + E+ +++S + + K +
Sbjct: 975 KIAALEARLEESTNYNQQLR--QELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWER 1032
Query: 404 NAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEI-----------------TVS 446
+++ ++L + E R LQ + +T++K++ TVS
Sbjct: 1033 ESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS 1092
Query: 447 FLQKITDLQNQ----------LKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLL 496
++ T LQ Q L Q Q +++ EN + +E + L
Sbjct: 1093 LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSL 1152
Query: 497 YEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVV 556
Y+ L + +L + E ++L+++HG + + + L N Q +K
Sbjct: 1153 YDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYN--QLLKQKG 1210
Query: 557 KLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLG 595
+L+D LK E K+ L + K ET + E K+ G
Sbjct: 1211 QLEDLEKMLKVEQEKM---LLENKNHET-VAAEYKKLCG 1245
Score = 77.0 bits (188), Expect = 5e-14
Identities = 137/628 (21%), Positives = 264/628 (42%), Gaps = 124/628 (19%)
Query: 52 KQLIELTRTNELL--KSKFSENGNQKNLRILSLEL---MKLRNKRE--TKMRGM-MAKQE 103
+QLI ++ N L+ K+ FSE G ++ ++L L L ++ + K E +++G+ +
Sbjct: 95 QQLIMMSLPNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKA 154
Query: 104 GMEMKLQVTQRSLEE------------SQGKIAQLEGKLVSIEKEKIDEKSE-TEKLLEY 150
+ +Q + E SQ I L + K IDE+ E +E ++E
Sbjct: 155 AVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIEL 214
Query: 151 IEEIS---------------CASDQVEKY-------------KLDIAQLEENLKEKNDEI 182
EE C S +++ K I +L + L+EK +++
Sbjct: 215 SEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQL 274
Query: 183 LSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILE 242
L KQ LE + E + R ++ N NL ++ ++ + +
Sbjct: 275 LDCKQELE----------------------QMEIELKRLQQENMNLLSDARSAR----MY 308
Query: 243 QQEREKLQQKELQIDSLLQQEKELSSSLH---------QKLCSFQEEMVKEKNLFEEELK 293
+ E + L++K +++D L + LH ++L + +++ K + E++L+
Sbjct: 309 RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLE 368
Query: 294 QTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATL 353
T DKL + E++ +L +L + R + K +EE L + LE + +L
Sbjct: 369 GTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEE-LMEENMTLEMAQKQSMDESL 427
Query: 354 LLQEKYDSMVQSLEDVTAQFES----YKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQ 409
L + + + ++ E A +S LT+S + L++EN SL + + + V+
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVE 487
Query: 410 ---HQILATESSNQ-----------EYVRMLLDLQ-----TKSALKETEIKEITVSFLQK 450
+IL E NQ E V+ LQ +K +KE E T+ L++
Sbjct: 488 GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Query: 451 ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQ 510
++ Q ++ +QE + Q R+ + + A + + + ++L+E + K +
Sbjct: 548 NSERQIKILEQENEHLNQTVSSL-RQRSQISAEARVKDIEKENKILHESI----KETSSK 602
Query: 511 LDAFEVEKQAL------LNEHGAAQEQL-NKIR--DSYAKLLGHQ--NLKQKIKHVVKLK 559
L E EK+ + E G E+L N++ + +LL + NLK + + L+
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALE 662
Query: 560 DENSQLKSEVSKLRCQLAKKKQSETKLQ 587
ENS+L+ E KL+ L K +L+
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLE 690
Score = 68.2 bits (165), Expect = 2e-11
Identities = 147/724 (20%), Positives = 300/724 (41%), Gaps = 159/724 (21%)
Query: 16 DRRIQDLETELEKMEAR----------LNAALREKTSLSANNATLEKQLIELTRTNELLK 65
+++IQ LE+EL+ +E L + + L N +LE++ +L + + L+
Sbjct: 776 NKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLE 835
Query: 66 SKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKI-- 123
+ Q ++ +LE ++ K ++K+ G+ + V + LE+ ++
Sbjct: 836 KENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVK 895
Query: 124 -AQLEGK-LVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDE 181
A ++ K LV++ ++ + EK +T+++ +E+++ ++EK L+ +L + + +D
Sbjct: 896 RATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLT---HELEKIGLNKERLLHDEQSTDDS 952
Query: 182 ILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKF-- 239
L +S E+ L K +E K LE E+ N +N+ L E++ +K+ +
Sbjct: 953 RYKLLESKLEST--LKKSLEIKEEKIAALEARLEESTN----YNQQLRQELKTVKKNYEA 1006
Query: 240 ILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVK----------EKNLFE 289
+ ++Q+ E++ Q I + + S ++L ++ +++ EK +
Sbjct: 1007 LKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALK 1066
Query: 290 EELKQTLDELDKLQQKEEQAERLVKQLEEE--------AKSRAEELKLLEEK--LKGKEA 339
+LKQ + + LQ + +R L+E+ AK + E L + L + A
Sbjct: 1067 TQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNA 1126
Query: 340 EL--EKSSAAHTQATLL-----LQEKYDSMVQSLEDVTA----QFESYKALTAS------ 382
+L ++SS + +++ L+ YDS+++ E + Q Y++L +
Sbjct: 1127 QLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKS 1186
Query: 383 ------------------------EIEDLKLENSSLQEKAAKAGKNAEDV--QHQILATE 416
++EDL+ QEK KN E V +++ L E
Sbjct: 1187 AHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGE 1246
Query: 417 SS--NQEYVRMLLD---LQT----------KSALKETEIK-------------EITVSFL 448
+ N Y ++L + LQT S L++T ++ +IT + L
Sbjct: 1247 NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKL 1306
Query: 449 QKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQ 508
+L +QLK E+ + L D+ + T LL + + +K
Sbjct: 1307 NNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRT------------LLEQNMESK----- 1349
Query: 509 LQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSE 568
D F VE++ + ++LN++R K L++KI K D + +
Sbjct: 1350 ---DLFHVEQRQYI-------DKLNELRRQKEK------LEEKIMDQYKFYDPSPPRRRG 1393
Query: 569 ---VSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAF----HHESKENFAL-KTPLK 620
K+R + KK + Q+ L L D S+ F H +S+++ ++ L+
Sbjct: 1394 NWITLKMRKLIKSKKDINRERQKSL--TLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLE 1451
Query: 621 EGNT 624
+G T
Sbjct: 1452 DGQT 1455
Score = 62.8 bits (151), Expect = 9e-10
Identities = 101/441 (22%), Positives = 190/441 (43%), Gaps = 65/441 (14%)
Query: 8 LLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSK 67
L E+ A +++ LET+ ++A++ A R+ SL N TL+ Q +L N L S+
Sbjct: 1058 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1117
Query: 68 FSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLE 127
+ NQ N ++L ++ L N+ E+ ++ L+ SL + K+ L
Sbjct: 1118 STSLMNQ-NAQLL-IQQSSLENENESVIKE--------REDLKSLYDSLIKDHEKLELLH 1167
Query: 128 GKLVSIEKEKIDE----KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEIL 183
+ S + I + KS + L ++ +Q+ K K + LE+ LK + +++L
Sbjct: 1168 ERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKML 1227
Query: 184 SLKQSLEENIVILSKQV----EDLNVKCQLLEKEKE----DH------VNRNREHNENLN 229
L+ E + K++ + LN L KE E DH +N ++ L
Sbjct: 1228 -LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE 1286
Query: 230 AEMQNLKQKFILEQQEREKLQ-QKEL--QIDSLLQQEKELSSSLHQKLC----SFQEEMV 282
AE LK+++ KL Q EL Q+ L++E Q L + E+ +
Sbjct: 1287 AEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNM 1346
Query: 283 KEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELE 342
+ K+LF E +Q +D+L++L++++E+ LEEK+ + +
Sbjct: 1347 ESKDLFHVEQRQYIDKLNELRRQKEK---------------------LEEKIMDQYKFYD 1385
Query: 343 KSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIED----LKLENSSLQEKA 398
S + L K +++S +D+ + + LT + + L+L + Q+ +
Sbjct: 1386 PSPPRRRGNWITL--KMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSS 1443
Query: 399 AKAGKNAEDVQHQILATESSN 419
+ + ED Q L T+ S+
Sbjct: 1444 SVGSNSLED--GQTLGTKKSS 1462
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 110 bits (274), Expect = 5e-24
Identities = 141/638 (22%), Positives = 291/638 (45%), Gaps = 76/638 (11%)
Query: 1 MTLLIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRT 60
+T+ + L ++ + + Q+++ E E+M A L + N+TL+++L E
Sbjct: 619 LTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEE---- 674
Query: 61 NELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQ 120
SE +KNL L ++ R + +T++R + + M +L +RS + +
Sbjct: 675 --------SEGELRKNLEEL-FQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREK 725
Query: 121 GKIAQLEGKLVSIEKEKIDEKSETEKLLEYIE-EISCASDQVEKYKLDIAQLEENLKEKN 179
G + + + ++ + K E E LL E E++ +++ Q + LKE+
Sbjct: 726 GALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQY 785
Query: 180 D-EILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK---EDHVNRNREHNENLNAEMQNL 235
D E+ +L++S+EE +K VE L + E+++ E V +E NE L + L
Sbjct: 786 DAELQALRESVEE----ATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEEL 841
Query: 236 KQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLC---SFQEEMVKEKNLFEEEL 292
+++ Q++ E L+ E + L++ + L + L ++E V + E EL
Sbjct: 842 ERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENEL 901
Query: 293 KQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQAT 352
+ L + Q+++Q L ++L+EE++ + E+L+ L+ +++ + L K+
Sbjct: 902 EAAQGNLSQTTQEQKQ---LSEKLKEESEQK-EQLRRLKNEMENERWHLGKTIEK----- 952
Query: 353 LLLQEKYDSMVQ----SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDV 408
LQ++ +V+ S ++ Q + YK E+ +++ + +A K+ A +
Sbjct: 953 --LQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKM 1010
Query: 409 QHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQK--ITDLQNQLKQQEEDFR 466
Q ++ E ++Y R + TK L E +K++ K + D +++L +Q ED
Sbjct: 1011 QDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKV 1070
Query: 467 KQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYN-----KTKPFQLQLDAFEVEKQ-- 519
QLE E E+ N + L+E I++ R E+L N + L+ D +E+Q
Sbjct: 1071 SQLEME---LEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNK 1127
Query: 520 -------ALLNEHGAAQEQL----------------NKIRDSYAKLLGHQNLKQKIKH-V 555
L + +++E L ++ RD L ++ L++K+K V
Sbjct: 1128 DLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELV 1187
Query: 556 VKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKV 593
+++ DE+ L + +L +L K+ + +EE++++
Sbjct: 1188 MQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRL 1225
Score = 105 bits (261), Expect = 2e-22
Identities = 134/576 (23%), Positives = 268/576 (46%), Gaps = 76/576 (13%)
Query: 44 SANNATLEKQLIELTRTN-ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAK- 101
S +N K+ + L + LKS+ + + N S +K ++++K+ +A+
Sbjct: 567 STDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAEL 626
Query: 102 QEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEY--------IEE 153
Q ++++++ Q EE + A LE +L S EK++E S ++ LE +EE
Sbjct: 627 QRQLQLEVKNQQNIKEERERMRANLE-ELRSQHNEKVEENSTLQQRLEESEGELRKNLEE 685
Query: 154 ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQS-------LEENIVILSKQVEDLNVK 206
+ + E+++ +I L++ L E +DE+ S K+S L E ++ + ++DL
Sbjct: 686 LFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDL--- 742
Query: 207 CQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKL-QQKELQIDSLLQQEKE 265
L+ KE+++ + R RE L A LK++ QE +KL +Q + ++ +L + +E
Sbjct: 743 --LIAKEEQEDLLRKRERE--LTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEE 798
Query: 266 LSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAE 325
+ ++ + L S +++ E +K +E +KLQ + E+ ER V QL+ +
Sbjct: 799 ATKNV-EVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQI----- 852
Query: 326 ELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLED--VTAQFESYKALTA-- 381
E LKG EA+ +++ +KY+ ++ LE+ V A+ E +A++A
Sbjct: 853 ------EDLKGDEAKAKET-----------LKKYEGEIRQLEEALVHARKEEKEAVSARR 895
Query: 382 ---SEIEDLK--LENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALK 436
+E+E + L ++ ++K E Q + L + E R L + K
Sbjct: 896 ALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQK 955
Query: 437 ETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLL 496
E+ +I + +LQNQL + +E R++L AE + E T E K RL
Sbjct: 956 --EMADIVEASRTSTLELQNQLDEYKEKNRREL-------AEMQRQLKEKTLEAEKSRLT 1006
Query: 497 YEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVV 556
++ ++ + + +L ++ + L + ++ L +D +L +LK +V
Sbjct: 1007 AMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTL---KDLEYELEAKSHLKDDRSRLV 1063
Query: 557 KLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNK 592
K Q++ +VS+L +L +++ + L E +++
Sbjct: 1064 K------QMEDKVSQLEMELEEERNNSDLLSERISR 1093
Score = 96.7 bits (239), Expect = 6e-20
Identities = 129/536 (24%), Positives = 242/536 (45%), Gaps = 64/536 (11%)
Query: 6 RVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLK 65
R L +GA + + E++K++ + +A L+ L + + E T+ E+L
Sbjct: 758 RELTALKGALKEEVSSHDQEMDKLKEQYDAELQ----------ALRESVEEATKNVEVLA 807
Query: 66 SKFSEN-----GNQKNLRILSLELMKLRNKRETKMRGMMAKQ------EGMEMKLQVTQR 114
S+ + + G + +++L E KL+ + E R + Q +G E K + T
Sbjct: 808 SRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKET-- 865
Query: 115 SLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEEN 174
L++ +G+I QLE LV KE+ E + LE E+ A + + + QL E
Sbjct: 866 -LKKYEGEIRQLEEALVHARKEE-KEAVSARRALE--NELEAAQGNLSQTTQEQKQLSEK 921
Query: 175 LKEKNDE---ILSLKQSLE-------ENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREH 224
LKE++++ + LK +E + I L K++ D+ + E ++ ++ +E
Sbjct: 922 LKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEK 981
Query: 225 NENLNAEMQN-LKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVK 283
N AEMQ LK+K + + E+ +L ++Q D + E+EL +Q+ Q+E +
Sbjct: 982 NRRELAEMQRQLKEKTL--EAEKSRLTAMKMQ-DEMRLMEEELRD--YQRA---QDEALT 1033
Query: 284 EKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEK 343
++ L E+ LK EL+ ++ RLVKQ+E++ EL EE+ + E+
Sbjct: 1034 KRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMEL---EEERNNSDLLSER 1090
Query: 344 SSAAHTQATLLLQEKYDSMV--QSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKA 401
S + Q L E Q LE E S I + LE S +++K
Sbjct: 1091 ISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRI--IHLEGSY---RSSKE 1145
Query: 402 GKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQK---ITDLQNQL 458
G + ++ +I E + R +LQ + E ++KE+ + + +TD ++QL
Sbjct: 1146 GLVVQ-MEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQL 1204
Query: 459 KQQEEDFRKQLEDEEGR----KAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQ 510
+ + ++Q+E+ E ++ K+ EL E+++ L +L + K +L+
Sbjct: 1205 SLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLK 1260
Score = 60.8 bits (146), Expect = 4e-09
Identities = 105/456 (23%), Positives = 196/456 (42%), Gaps = 79/456 (17%)
Query: 9 LQERGAQ-DRRIQDL--------------ETELEKME-ARLNAALREKTSLSANNA---- 48
L+ R AQ R+I+DL E E+ ++E A ++A EK ++SA A
Sbjct: 841 LERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENE 900
Query: 49 --TLEKQLIELTRTNELLKSKFSENGNQKN-LRILSLELMKLR-------NKRETKMRGM 98
+ L + T+ + L K E QK LR L E+ R K + +M +
Sbjct: 901 LEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADI 960
Query: 99 MAKQEGMEMKLQ--------VTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEY 150
+ ++LQ +R L E Q QL+ K + EK ++ +++
Sbjct: 961 VEASRTSTLELQNQLDEYKEKNRRELAEMQ---RQLKEKTLEAEKSRLTAMKMQDEMRLM 1017
Query: 151 IEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQL- 209
EE+ ++ LE+ LK+ E L K L+++ L KQ+ED + ++
Sbjct: 1018 EEELRDYQRAQDEALTKRQLLEQTLKDLEYE-LEAKSHLKDDRSRLVKQMEDKVSQLEME 1076
Query: 210 LEKEKE------DHVNRNREHNENLNAEM-------QNLK-QKFILEQQEREKLQQKELQ 255
LE+E+ + ++R+RE E L E+ Q+L+ K LE+Q ++ L+ + +
Sbjct: 1077 LEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKD-LKSRIIH 1135
Query: 256 IDSLLQQEKE-LSSSLHQKLCSFQEEMVKEK----NL------FEEELKQTLDELD---- 300
++ + KE L + ++ ++ + E+ NL E ++K+ + ++D
Sbjct: 1136 LEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHL 1195
Query: 301 KLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYD 360
L +++Q +K ++ + + EE+ LE K + ELE+ + LQ + +
Sbjct: 1196 SLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEH----LQGQLN 1251
Query: 361 SMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQE 396
SM + L + S + +DL + SL E
Sbjct: 1252 SMKKDLR--LKKLPSKVLDDMDDDDDLSTDGGSLYE 1285
Score = 41.2 bits (95), Expect = 0.003
Identities = 31/158 (19%), Positives = 76/158 (48%), Gaps = 9/158 (5%)
Query: 12 RGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN 71
R +++ + +E + ++E RL + R++ +L +N LE+++ EL + ++
Sbjct: 1141 RSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQ 1200
Query: 72 GNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLV 131
+Q +LR+ +++ + E + +E + QR LEE L+G+L
Sbjct: 1201 KDQLSLRLKAMKRQVEEAEEEI---------DRLESSKKKLQRELEEQMDMNEHLQGQLN 1251
Query: 132 SIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIA 169
S++K+ +K ++ L + ++ ++D Y+ ++
Sbjct: 1252 SMKKDLRLKKLPSKVLDDMDDDDDLSTDGGSLYEAPVS 1289
Score = 36.6 bits (83), Expect = 0.073
Identities = 54/241 (22%), Positives = 98/241 (40%), Gaps = 42/241 (17%)
Query: 388 KLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSF 447
KL+ ++ A + ++ ++L TE S + V L +S KE E+K T +
Sbjct: 446 KLQGAAHGASCAHSRPPQPNIDGKVLETEGSQESTVIRAPSLGAQSK-KEEEVKTATATL 504
Query: 448 LQKITDLQNQLKQQEEDF-RKQLEDEEGRKAEKENTTA-------ELTEEINKWRLLYEE 499
+ LQN+ D K++ + A T ELT++ N+ +
Sbjct: 505 M-----LQNRATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNE-ETAKQI 558
Query: 500 LYNKTKPFQLQLDAFEVEKQALLNEH---------GAAQ----------------EQLNK 534
LYN K D K L+ E G+AQ EQ +K
Sbjct: 559 LYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSK 618
Query: 535 IRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVL 594
+ A+L + L+ ++K+ +K+E ++++ + +LR Q +K + + LQ+ L +
Sbjct: 619 LTIEVAEL--QRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESE 676
Query: 595 G 595
G
Sbjct: 677 G 677
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 109 bits (273), Expect = 7e-24
Identities = 123/570 (21%), Positives = 245/570 (42%), Gaps = 65/570 (11%)
Query: 22 LETELEKMEARLNAALREKTSLSAN-------NATLEKQLIELTRTNELLKSKFSENGNQ 74
L+ +L + E R A + T L A A L+ L ++ E ++ K SE+ +Q
Sbjct: 643 LQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQ 702
Query: 75 KNLRILSLELMKLRNKRETKM--------RGMMAKQEGMEMKLQVTQRSLEESQGKIAQL 126
+ LE + KR+ ++ ++ ++ +E++LQ +R ++ ++ L
Sbjct: 703 QEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGL 762
Query: 127 EGKLVSIEKEKIDEKSETE-------KLLEYIEEISCASDQVE------KYKLDIAQLEE 173
+E + + + +L I+ ++ A + ++ K +LD + +
Sbjct: 763 SSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQA 822
Query: 174 NLKEKNDEILSLKQSLEENIVILSKQV----EDLNVKCQLLEKEKEDHVNRNREHNENLN 229
+E++ L Q+ +E L +Q +++N + EKE+ H + E+L
Sbjct: 823 E-QERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLE 881
Query: 230 AEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFE 289
E L+ + +Q E E +Q Q +E + LC Q E KE+
Sbjct: 882 REKMELEMRLKEQQTEMEAIQA----------QREEERTQAESALCQMQLETEKERVSLL 931
Query: 290 EELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHT 349
E L QT EL Q Q ERL + ++ + E +L+ +L+ + EL++++ H
Sbjct: 932 ETLLQTQKELADASQ---QLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHR 988
Query: 350 QATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKA---GKNAE 406
LQE+ S++Q D+ Q E K+ ++ + +L +QEK + + +
Sbjct: 989 DDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQK 1048
Query: 407 DVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFR 466
+++ + + S E + LL LQ ++++ E+ + +Q+ Q +L Q E R
Sbjct: 1049 ELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQD-MQEAQGEQKELSAQMELLR 1107
Query: 467 KQLEDEEGRKAEKENTTAELTEEINKWRLLYEEL-------YNKTKPFQLQLDAFEVEKQ 519
++++++E +E A+L EE+ + ++L K QL+L + E + +
Sbjct: 1108 QEVKEKEADFLAQE---AQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLE 1164
Query: 520 ALLNE-----HGAAQEQLNKIRDSYAKLLG 544
AL E AQ QL + + + LG
Sbjct: 1165 ALAAEQQPGNQAQAQAQLASLYSALQQALG 1194
Score = 101 bits (252), Expect = 2e-21
Identities = 140/617 (22%), Positives = 262/617 (42%), Gaps = 78/617 (12%)
Query: 1 MTLLIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRT 60
+TL + QE AQ +I DLE+ + L +E S +Q+ EL R
Sbjct: 1593 LTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKS-------QREQIEELQRQ 1645
Query: 61 NELLKSKFSENGNQKNLRILSLELMKLRNKRETKMR-------GMMAKQEGMEM--KLQV 111
E L + L+ +++++ + R+TK+ + ++ G E+ + Q+
Sbjct: 1646 KEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQL 1705
Query: 112 TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQL 171
Q EE +G G L ++ D++ E E E+I E+ DQ+E Q
Sbjct: 1706 MQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLE-------QQ 1758
Query: 172 EENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAE 231
+ L K E L E+ IV+L +Q+++ + +L E ++L ++
Sbjct: 1759 LQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKE--------------QSLQSQ 1804
Query: 232 MQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEE 291
+ ++ QE E LQQ++ Q ++ KE + +L L E+
Sbjct: 1805 LDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGAL---------------EQ 1849
Query: 292 LKQTLDEL-DKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQ 350
TL E +LQ +EQA RL ++L E + R + L+ + L+ + E EK+ A Q
Sbjct: 1850 AHMTLKERHGELQDHKEQARRLEEELAVEGR-RVQALEEVLGDLRAESREQEKALLALQQ 1908
Query: 351 ATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQH 410
++++ ++L+D Q ++ E+E L+ E+ S + + A AE +Q
Sbjct: 1909 QCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQE 1968
Query: 411 QILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQ-- 468
+ ++ Q + LL+ A ++ T + + Q +Q EE R Q
Sbjct: 1969 ALGKAHAALQGKEQHLLE----QAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEG 2024
Query: 469 -LEDEEGRKAEK----ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLN 523
++D++ R E + A+ EE+ + + E+L K+ ++Q + + EKQ L
Sbjct: 2025 EIQDQDLRYQEDVQQLQQALAQRDEEL-RHQQEREQLLEKSLAQRVQENMIQ-EKQNLGQ 2082
Query: 524 EHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSE-------VSKLRCQL 576
E +E++ + S +L L QK + +++L++ + E S + Q
Sbjct: 2083 ER--EEEEIRGLHQSVREL--QLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQS 2138
Query: 577 AKKKQSETKLQEELNKV 593
K E +LQ EL ++
Sbjct: 2139 LKLDSLEPRLQRELERL 2155
Score = 95.9 bits (237), Expect = 1e-19
Identities = 124/590 (21%), Positives = 264/590 (44%), Gaps = 57/590 (9%)
Query: 22 LETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILS 81
+ TEL+ ++ +L+ EK+ +LE +L+EL T L+S+ LR
Sbjct: 1283 VHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSR---------LRRAE 1333
Query: 82 LELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQ---LEGKL------VS 132
L+ M+ + +RE + A +E + +++ Q ++ E++ + + LE L +
Sbjct: 1334 LQRMEAQGEREL----LQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALK 1389
Query: 133 IEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEEN 192
++ E+++ + E + L+ E+ A Q + + ++A L + L E+ +E+ +L+ ++E
Sbjct: 1390 LKNEEVESERERAQALQEQGELKVA--QGKALQENLALLTQTLAEREEEVETLRGQIQE- 1446
Query: 193 IVILSKQVEDLNVKCQLLE---KEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKL 249
L KQ E +LL K++ V+ +E + L L+ + Q+ +KL
Sbjct: 1447 ---LEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKL 1503
Query: 250 QQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQA 309
+ QI L + + + L +L E+ K+ + E + Q D L+++
Sbjct: 1504 TVQREQIRELEKDRETQRNVLEHQLL----ELEKKDQMIESQRGQVQD----LKKQLVTL 1555
Query: 310 ERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDV 369
E L +LEE + KL++E E + E A T TL L+E+ + Q+
Sbjct: 1556 ECLALELEENHHKMECQQKLIKE----LEGQRETQRVALTHLTLDLEERSQEL-QAQSSQ 1610
Query: 370 TAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESS---NQEYVRML 426
ES+ + A E+++ E S +E+ + + E + + + +E +++L
Sbjct: 1611 IHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVL 1670
Query: 427 LDLQTK-SALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAE 485
D +T+ + + E ++++I +S ++ +L Q + +E + + ++ E+
Sbjct: 1671 EDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLI 1730
Query: 486 LTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGH 545
L ++ + E ++ Q D E + Q L + G L++ L
Sbjct: 1731 LRDKEKEVECQQEHIHE----LQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVL--- 1783
Query: 546 QNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLG 595
Q Q+ + +LK+++ L+S++ + + LA++ Q LQ+E + G
Sbjct: 1784 QQQLQEAREQGELKEQS--LQSQLDEAQRALAQRDQELEALQQEQQQAQG 1831
Score = 92.8 bits (229), Expect = 9e-19
Identities = 134/613 (21%), Positives = 268/613 (43%), Gaps = 98/613 (15%)
Query: 27 EKMEARLNAALREKTSLSANNATLE----KQLIELTRTNELLKSKFSENGNQKNLRILSL 82
E+ + L+ A+RE+ L LE + L EL E L+S E
Sbjct: 508 EEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEG----------- 556
Query: 83 ELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSI-EKEKIDEK 141
+L + +T++ +A+ E +L ++ +L+ + KL ++ E +D+
Sbjct: 557 ---ELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKV 613
Query: 142 SETEKLLEYIEEISCASDQVEK-------YKLDIAQLE---ENLKEKNDEILSLKQSLEE 191
++LL+ EE ++E ++D+A+ E E L EKN + + Q EE
Sbjct: 614 GLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEE 673
Query: 192 NIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ-------Q 244
L + D+ + + ++K+ ++ +R E +++ L Q+ ++ Q
Sbjct: 674 AGAELQADLRDIQEEKEEIQKK----LSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQ 729
Query: 245 EREKLQQKELQIDSLLQQEKELSSSLHQKL--CSFQEEMVKEKNLFEEELKQTLDELDKL 302
E+E L +++ ++ LQ + L ++L S +E++ E +LFE + + ++ E+ K
Sbjct: 730 EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELL-ESSLFEAQQQNSVIEVTKG 788
Query: 303 Q-----QKEEQAERLVK---------------QLEEEAKSRAEELKLLEEKLKGKEAELE 342
Q Q QA+ +++ Q E+E + A +L E++ GK A LE
Sbjct: 789 QLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQE--GKTA-LE 845
Query: 343 KSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAG 402
+ AAH + L+EK++ E Q E KAL + E E ++LE
Sbjct: 846 QQKAAHEKEVNQLREKWEK-----ERSWHQQELAKALESLEREKMELE------------ 888
Query: 403 KNAEDVQHQILATESSNQEYVRMLLDLQTKSAL--KETEIKEITVSFLQKITDLQNQLKQ 460
++ Q ++ A ++ +E Q +SAL + E ++ VS L+ + Q +L
Sbjct: 889 MRLKEQQTEMEAIQAQREEE-----RTQAESALCQMQLETEKERVSLLETLLQTQKELAD 943
Query: 461 QEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQA 520
+ + +D + +K +++ TT L ++ + + EL + + L A + E +
Sbjct: 944 ASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQ---RELKEAARQHRDDLAALQEESSS 1000
Query: 521 LLNEHGAAQEQLNKIRDSY-----AKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQ 575
LL + Q+Q+ ++ ++ L Q +++K++ + +L+ E + L
Sbjct: 1001 LLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLS 1060
Query: 576 LAKKKQSETKLQE 588
L +K+Q LQE
Sbjct: 1061 LMEKEQRLLVLQE 1073
Score = 87.0 bits (214), Expect = 5e-17
Identities = 122/639 (19%), Positives = 272/639 (42%), Gaps = 64/639 (10%)
Query: 12 RGAQDRRIQDLETELEKMEARLNAA---LREKTSLSANNATLEKQLIELTRTNELLKSKF 68
R A + +++E+E E+ +A + + +L N A L + L E E L+ +
Sbjct: 1385 RSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQI 1444
Query: 69 SENGNQKNLRILSLELMKL----RNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA 124
E Q+ ++ +LEL+ L RN+ + + + E L+ +++E + K+
Sbjct: 1445 QELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLT 1504
Query: 125 QLEGKLVSIEKEKIDEKSETEKLLEYIEE----ISCASDQVEKYKLDIA-------QLEE 173
++ +EK++ +++ E L +E+ I QV+ K + +LEE
Sbjct: 1505 VQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEE 1564
Query: 174 N---LKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNA 230
N ++ + I L+ E V L+ DL + Q L+ + ++ H+ L
Sbjct: 1565 NHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQ-IHDLESHSTVLAR 1623
Query: 231 EMQNLKQKFILEQQEREKLQ-QKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFE 289
E+Q Q+ ++++ E+LQ QKE L ++++EL +++ +++ ++ + E
Sbjct: 1624 ELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQ-KERIQVLEDQRTRQTKILE 1682
Query: 290 EELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHT 349
E+L+Q L + ++ +L+++ EE K ++ + E +K + EK
Sbjct: 1683 EDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQ 1742
Query: 350 QATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQ 409
+ LQE D + Q L+ + + L + +++ + LQE + + +Q
Sbjct: 1743 EHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQ 1802
Query: 410 HQILATE---SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLK------Q 460
Q+ + + + + L Q ++ +E +KE + + LK Q
Sbjct: 1803 SQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQ 1862
Query: 461 QEEDFRKQLEDE---EGRKAEK-----ENTTAELTEEINKWRLLYEELYNKTKPFQL--- 509
++ ++LE+E EGR+ + + AE E+ L ++ + + ++
Sbjct: 1863 DHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETR 1922
Query: 510 ------------------QLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQK 551
+L+A E Q+ ++ AA+ + ++++ K H L+ K
Sbjct: 1923 ALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGK--AHAALQGK 1980
Query: 552 IKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEEL 590
+H+++ + + L++ + L+ L + +L+E L
Sbjct: 1981 EQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEAL 2019
Score = 74.7 bits (182), Expect = 2e-13
Identities = 144/684 (21%), Positives = 289/684 (42%), Gaps = 83/684 (12%)
Query: 4 LIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTS---------------LSANNA 48
L+ +QE+ + + ++ ELE+ +A L +L EK LSA
Sbjct: 1028 LVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQ 1087
Query: 49 TLEK---QLIELTRTNELLKSKFSENGNQKNLRILS-----LELMKLRNKRETKMRGMMA 100
+++ + EL+ ELL+ + E K L+ LE ++ + E ++R +
Sbjct: 1088 DMQEAQGEQKELSAQMELLRQEVKE----KEADFLAQEAQLLEELEASHITEQQLRASLW 1143
Query: 101 KQEGMEMKLQVTQRSLE---------ESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYI 151
QE +LQ+ RS E + G AQ + +L S+ + + E
Sbjct: 1144 AQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSAL---QQALGSVCESR 1200
Query: 152 EEISCASDQVEK-YKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLL 210
E+S D + L+ Q K +L+ S E L K +DL Q
Sbjct: 1201 PELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTAL-SAEAVASALHKLHQDLWKTQQTR 1259
Query: 211 E------KEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEK 264
+ ++ E+ + ++ E+Q+L+++ Q+E+ K + K+ ++S L +
Sbjct: 1260 DVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELH 1319
Query: 265 ELSSSLHQKLCSFQEEMVK---EKNLFEEELKQTLDELDKLQQKEEQAERLVKQ---LEE 318
E +SL +L + + ++ E+ L + + +++ LQ +A LEE
Sbjct: 1320 ETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEE 1379
Query: 319 EAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATL------LLQEKYDSMVQSLEDVTAQ 372
+ ++ LKL E++ E+E E++ A Q L LQE + Q+L + +
Sbjct: 1380 DLRTARSALKLKNEEV---ESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEE 1436
Query: 373 FESYKALTAS-----EIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLL 427
E+ + E++ LE SL K + + Q Q L S E++ M +
Sbjct: 1437 VETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAV 1496
Query: 428 -DLQTKSALKETEIKEITVSFLQKITDLQNQLKQQE------EDFRKQLEDEEGRKAEKE 480
+ + K ++ +I+E+ + L++QL + E E R Q++D + + E
Sbjct: 1497 QEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLE 1556
Query: 481 NTTAELTEEINKW---RLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRD 537
EL E +K + L +EL + + ++ L ++ + E A Q++ + +
Sbjct: 1557 CLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDL-E 1615
Query: 538 SYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIK 597
S++ +L + L+++ + V +++ +L+ + L L ++ Q E LQ+E +VL +
Sbjct: 1616 SHSTVLARE-LQERDQEVKSQREQIEELQRQKEHLTQDLERRDQ-ELMLQKERIQVLEDQ 1673
Query: 598 HFDPSKAFHHESKENFALKTPLKE 621
+K + ++ +K L+E
Sbjct: 1674 RTRQTKILEEDLEQ---IKLSLRE 1694
Score = 73.9 bits (180), Expect = 4e-13
Identities = 119/627 (18%), Positives = 263/627 (41%), Gaps = 56/627 (8%)
Query: 8 LLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSK 67
L++ + R Q+ + L+++ + + E+ A + E L + + S+
Sbjct: 323 LMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSL----ELDSSIFSQ 378
Query: 68 FSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG---KIA 124
F K L ++ L + R + + + QE + + Q + EE + ++
Sbjct: 379 FDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQ 438
Query: 125 QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 184
+L G+ ++ + +D + E + L + E + A +++ + + Q L+ N E+
Sbjct: 439 KLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQL 498
Query: 185 LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ 244
S + +Q E+L++ + E+ +E + + +E+L+ E+ L++
Sbjct: 499 QGDSAQGQ---KEEQQEELHLAVRERERLQEMLMGLEAKQSESLS-ELITLREALESSHL 554
Query: 245 EREKLQQKELQIDSLL----QQEKELSSSLHQ-------------KLCSFQEEMVKEKNL 287
E E L+Q++ ++ + L Q ELSSS + KL + E + +K
Sbjct: 555 EGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVG 614
Query: 288 FEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKS--S 345
++L Q +E + + E AE+ L+ + + + L EK EA+L+K+ +
Sbjct: 615 LNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEA 674
Query: 346 AAHTQATLL--------LQEKYDSMVQSLEDVTAQFESYK----------ALTASEIEDL 387
A QA L +Q+K E T Q E A E E L
Sbjct: 675 GAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEAL 734
Query: 388 KLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSF 447
E ++L+ + ++ +D+ Q+ S+ + L + Q ++++ E ++ V
Sbjct: 735 VREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQ- 793
Query: 448 LQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAE---LTEEINKWRLLYEELYNKT 504
+Q +T + ++ + + +L+ E + ++ + A E+ K L ++ ++
Sbjct: 794 IQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEK 853
Query: 505 KPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQ 564
+ QL+ + +E E+ E A E L + + L Q + + + ++E +Q
Sbjct: 854 EVNQLR-EKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQR-EEERTQ 911
Query: 565 LKSEVSKLRCQLAKKKQS--ETKLQEE 589
+S + +++ + K++ S ET LQ +
Sbjct: 912 AESALCQMQLETEKERVSLLETLLQTQ 938
Score = 55.1 bits (131), Expect = 2e-07
Identities = 110/505 (21%), Positives = 215/505 (42%), Gaps = 86/505 (17%)
Query: 6 RVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLK 65
R L +E + RR+Q LE L + A +EK L+ L++Q E + +E+
Sbjct: 1869 RRLEEELAVEGRRVQALEEVLGDLRAESRE--QEKALLA-----LQQQCAEQAQEHEVET 1921
Query: 66 SKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKI-A 124
++ Q ++K R++ +R E + +L+E+ GK A
Sbjct: 1922 RALQDSWLQAQA------VLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHA 1975
Query: 125 QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 184
L+GK ++ + E++E + LE AS + LD Q
Sbjct: 1976 ALQGK-----EQHLLEQAELSRSLE-------ASTATLQASLDACQAHS----------- 2012
Query: 185 LKQSLEENIVILSKQVEDLNVK----CQLLEK---EKEDHVNRNREHNENLNAEMQNLKQ 237
+ LEE + I +++D +++ Q L++ ++++ + +E + L + Q
Sbjct: 2013 --RQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQ 2070
Query: 238 KFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQE-EMVKEKNLFE------- 289
+ ++++++ +++E +I L Q +EL +L QK E +++N E
Sbjct: 2071 ENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHK 2130
Query: 290 ----EELKQTLDELD-KLQQKEEQAERLVKQLEE---EAKSRAEELKLLEEKLKGKEAEL 341
EE LD L+ +LQ++ E+ + ++Q E E + +A++L L + K + L
Sbjct: 2131 TSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSL 2190
Query: 342 EKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKA 401
++ A QA++L + DS Q L+D LT +E +L + A
Sbjct: 2191 QE-VAMFLQASVL---ERDSEQQRLQDEL-------ELTRRALEKERLHSPGATSTAELG 2239
Query: 402 GKNAEDVQ-HQILATES-------SNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 453
+ + VQ ++ E+ Q + + L LQ A E + + +Q
Sbjct: 2240 SRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQ---- 2295
Query: 454 LQNQLKQQEEDFRKQLEDEEGRKAE 478
L++ L+Q E + R++L+ E R A+
Sbjct: 2296 LRSTLEQVERE-RRKLKREAMRAAQ 2319
Score = 42.7 bits (99), Expect = 0.001
Identities = 112/543 (20%), Positives = 218/543 (40%), Gaps = 84/543 (15%)
Query: 107 MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 166
MK Q Q LEE + Q + + K+ E ++ + + +V +Y+
Sbjct: 11 MKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATL--VRKLQAKVLQYRS 68
Query: 167 DIAQLEENLKEKNDEILSLKQSLEE-NIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHN 225
+LE+ L+ I +++EE N+ L ++E+ +C+ L E + + E
Sbjct: 69 WCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLA-EVNTQLRLHMEKA 127
Query: 226 ENLNAEMQNLKQKFILE-QQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKE 284
+ +N ++ +K ++ + R++L +KE Q + K H +L S E+V
Sbjct: 128 DVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTF 187
Query: 285 KNLFEEELKQTLDELDKLQQKEEQAERLVK----QLEEEAKSRA----------EELKLL 330
+ F E T +L +L+ + + + +L A+SR E +LL
Sbjct: 188 RRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLL 247
Query: 331 EEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLED-VT----------AQFESYKAL 379
L K ELEK + +Q + L+ + D L+D VT Q E Y+ +
Sbjct: 248 --LLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKM 305
Query: 380 TAS---EIEDLKLENSSLQEKAAKAGKNAEDVQ----------HQILATESSN------- 419
+ +E L+ ++ L E A +NA++ + Q++ E N
Sbjct: 306 IKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGH 365
Query: 420 ------QEYVRMLLDLQ-TKSALKETEIKEITVSFLQKITDLQNQLK--QQEEDFRKQLE 470
+ D Q AL T ++ + Q + DL+ QL Q+ + +Q
Sbjct: 366 ENSLELDSSIFSQFDYQDADKAL--TLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQH 423
Query: 471 D---EEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGA 527
D EEG+ L + + K + L +T Q ++D+ E++ L
Sbjct: 424 DQWEEEGK---------ALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREE 474
Query: 528 AQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQ 587
++QL + +L +++ ++L+ +++Q + E + LA +++ +LQ
Sbjct: 475 LRQQLEVLEQEAWRL-------RRVNVELQLQGDSAQGQKEEQQEELHLAVRERE--RLQ 525
Query: 588 EEL 590
E L
Sbjct: 526 EML 528
Score = 34.7 bits (78), Expect = 0.28
Identities = 53/292 (18%), Positives = 114/292 (39%), Gaps = 52/292 (17%)
Query: 15 QDRRIQDLETELEKMEARLNAALREKTS-----------LSANNATLEKQLIELTRTNEL 63
Q ++ LE L++ RL AALR+ + L+ + A + + L
Sbjct: 2137 QSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMF 2196
Query: 64 LKSKFSENGNQKNLRILSLELMKLRNKRET-----------------------KMRGMMA 100
L++ E +++ LEL + ++E ++ G+ A
Sbjct: 2197 LQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEA 2256
Query: 101 KQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKL--------LEYIE 152
+ M+ Q ++ LE Q +A+LE +++ + +S E++ E +
Sbjct: 2257 EPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMR 2316
Query: 153 EISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK 212
S ++ K ++ +KN + + + L++ +V+L Q+ L K
Sbjct: 2317 AAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAE-LQKEVVLLQAQLT-------LERK 2368
Query: 213 EKEDHVNRNREHNENLNAEMQNLKQKFILEQQ--EREKLQQKELQIDSLLQQ 262
+K+D++ R+ + + L +L + Q E L+ + ++D L Q
Sbjct: 2369 QKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQ 2420
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 109 bits (272), Expect = 9e-24
Identities = 150/613 (24%), Positives = 279/613 (45%), Gaps = 84/613 (13%)
Query: 23 ETELEKMEARLNAALREKTSLSANNATLEKQLIELTRT-NELLKSKFSENGNQKNLRILS 81
E E+E++ ++ L+EK SL E ++ EL RT + + K +GN ++L +
Sbjct: 1353 EKEMEELHHNIDDLLQEKKSL-------ECEVEELHRTVQKRQQQKDFIDGNVESL-MTE 1404
Query: 82 LELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEK---- 137
LE+ K E ++ + E +E L + L E+ +A+ E +L S KEK
Sbjct: 1405 LEIEKSLKHHED----IVDEIECIEKTLLKRRSELREADRLLAEAESEL-SCTKEKTKNA 1459
Query: 138 -----------IDEKSETEKLLEYIEEISC----ASDQVEKYKLDIAQLEENLKEKNDEI 182
+ +S+ E+L +E + A Q+ + D LE++ K K +EI
Sbjct: 1460 VEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQH-KIKQEEI 1518
Query: 183 LS----LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQK 238
L + + + + LSK+ E L + Q L+K+ E RN +H+ +Q LK+
Sbjct: 1519 LKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIE-MAERNEDHH------LQVLKES 1571
Query: 239 FILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDE 298
+L Q +R +L++ + Q+ S Q+ L L K +E +L + + Q +
Sbjct: 1572 EVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKK--------EELHLLQGSMVQAKAD 1623
Query: 299 LDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELE-KSSAAHTQATLLLQE 357
L ++A RL + E + E+K L E+L ++ EL + S TQ TL+ QE
Sbjct: 1624 L-------QEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQE 1676
Query: 358 KYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQ-------EKAAKAGKNAEDVQH 410
+ ++L+ V Q +K + ++ L+LEN LQ ++ ++ K V
Sbjct: 1677 -IEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLE 1735
Query: 411 QILATESSNQEYVRMLLDLQTKSALKETEIKEI--TVSFLQKITDLQNQLKQQEEDFRKQ 468
+ L E+ Q + +++ + L E + +EI + + + L +++ED +++
Sbjct: 1736 EKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEK 1795
Query: 469 LEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAA 528
+ E + A+ + A E + E+L + Q +LD +K +L N+ A
Sbjct: 1796 CDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAM 1855
Query: 529 QEQL-------NKIRDSYAKLLGHQNL-KQKIKHVVKLKD----ENSQLKSEVSKLRCQL 576
Q+QL N +++ A + H NL KQ + H K +D E ++L+ ++S+ +
Sbjct: 1856 QQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRF 1915
Query: 577 AK-KKQSETKLQE 588
+K+ ETK Q+
Sbjct: 1916 EDCQKEEETKQQQ 1928
Score = 99.0 bits (245), Expect = 1e-20
Identities = 148/641 (23%), Positives = 288/641 (44%), Gaps = 84/641 (13%)
Query: 5 IRVLLQERGAQDRRI-QDLETELEKMEARLNAALREKTSLSANNATLEKQLIELT----- 58
+ V + ER Q I Q++E E E ++ L + KT L L+ + EL
Sbjct: 1659 LNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQ 1718
Query: 59 ---RTNELLKSKFS---ENGNQKNLRILS------LELMKL---RNKRE-----TKMRGM 98
R +EL K++ + E +NL+ +S +E K R+KRE + R +
Sbjct: 1719 HDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRAL 1778
Query: 99 MAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCAS 158
+ E + + + Q + + K+AQ + L + E+ E+S EKL + ++
Sbjct: 1779 QSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQEL 1838
Query: 159 DQVEKYKL----DIAQLEENLKEKNDEILSLKQSL----------EENIVILSKQVEDLN 204
DQ+ + KL DI+ +++ L+EK + + SL++ L +++++ +K + L
Sbjct: 1839 DQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLL 1898
Query: 205 VKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEK 264
+ L+K+ + NR E+ E + +Q+ + Q E E+ + K +Q + + Q+ +
Sbjct: 1899 SEQTRLQKDISEWANRF----EDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQ 1954
Query: 265 ELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRA 324
+ S KL + + + ++++ E+EL +LD++ K AE V+ L+EE +
Sbjct: 1955 KERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEER-WC 2013
Query: 325 EELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQF--ESYKA--LT 380
E L+ + K + +E E+ + L LQ++ DSM + QF E KA
Sbjct: 2014 ESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQV 2073
Query: 381 ASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE---SSNQEYVRMLLDLQTKSALKE 437
AS E LK++ S L++ + + +Q ++ E N E R L+
Sbjct: 2074 ASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLM---------- 2123
Query: 438 TEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLY 497
E+ ++ + T+L+ Q+ Q++ R+Q+E + + K E+ +
Sbjct: 2124 KELNQMQYEY----TELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFL 2179
Query: 498 EEL-------YNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLN----KIRDSYAKLLGHQ 546
EL + + + +L++ + +NE G +E+LN I D + + +
Sbjct: 2180 PELPADLEAILERNENLEGELESLKENLPFTMNE-GPFEEKLNFSQVHIMDEHWR---GE 2235
Query: 547 NLKQKIKHVVKLKDENSQLKSEVSKLRCQLAK-KKQSETKL 586
L++K++H + +QL+ +SK L K K+Q+E L
Sbjct: 2236 ALREKLRH--REDRLKAQLRHCMSKQAEVLIKGKRQTEGTL 2274
Score = 91.3 bits (225), Expect = 2e-18
Identities = 128/641 (19%), Positives = 278/641 (43%), Gaps = 84/641 (13%)
Query: 20 QDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKS--KFSENGNQKNL 77
+DLE K E L + + ++ L K+ +LT + L+ + +E +L
Sbjct: 1506 KDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHL 1565
Query: 78 RILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKE- 136
++L + L+ KR ++ + ++ + ++ V R L + ++ L+G +V + +
Sbjct: 1566 QVLKESEVLLQAKR-AELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADL 1624
Query: 137 ----KIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLE-- 190
++ E TEK +I E+ +++ K +L + E+ ++ +KQ +E
Sbjct: 1625 QEALRLGETEVTEKC-NHIREVKSLLEELSFQK---GELNVQISERKTQLTLIKQEIEKE 1680
Query: 191 -ENIVI----LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQE 245
EN+ + +SK +L +L+ E + +H++ ++ E++ + + E+ E
Sbjct: 1681 EENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVS-ELEKTQVAVLEEKLE 1739
Query: 246 REKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQK 305
E LQQ Q ++ +K+L +++ E M E + ++ E + LQ+K
Sbjct: 1740 LENLQQISQQQKGEIEWQKQLLERDKREI----ERMTAESRALQSCVECLSKEKEDLQEK 1795
Query: 306 EE-------QAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSS----AAHTQATLL 354
+ Q +R++ EE +K L+ LE ++ + EL++ + + H + +
Sbjct: 1796 CDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAM 1855
Query: 355 ---LQEKYDSMVQSLEDVTAQFESYKALTASEI------EDLKL-ENSSLQEKAAKAGKN 404
LQEK ++ V SL++ A + + L ++ +D+ L E + LQ+ ++
Sbjct: 1856 QQQLQEKREA-VNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANR 1914
Query: 405 AEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQ------- 457
ED Q + E + Q+ +++L + ++ LK + +E+ LQK + +
Sbjct: 1915 FEDCQKE----EETKQQQLQVLQNEIEENKLKLVQ-QEMMFQRLQKERESEESKLETSKV 1969
Query: 458 -LKQQEEDFRKQLEDEEGR------KAEKENTTAELTEEINKWRLLYEELYNKTK----- 505
LK+Q+ K+L D++ + K +E +W E+ ++TK
Sbjct: 1970 TLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSE 2029
Query: 506 -------------PFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKI 552
Q + D+ + L N+ +++ K S + L Q Q
Sbjct: 2030 REQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQR-SQLE 2088
Query: 553 KHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKV 593
K++++ K ENS ++ E++ + + +L +ELN++
Sbjct: 2089 KNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQM 2129
Score = 84.3 bits (207), Expect = 3e-16
Identities = 155/660 (23%), Positives = 278/660 (42%), Gaps = 142/660 (21%)
Query: 22 LETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLK--------SKFSENGN 73
L+T+LE E +++AA +T LS + +EK ++ R E K K SE G
Sbjct: 435 LDTQLEDKEKKISAA---QTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGK 491
Query: 74 QKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSI 133
+ LS L +L NK +QE ++++LQ+ ++ +E GK Q E K + I
Sbjct: 492 DLLYKQLSGRL-QLVNK---------LRQEALDLELQM-EKQKQEIAGK--QKEIKDLQI 538
Query: 134 EKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLE-ENLKEKNDEILSLKQSLEEN 192
+ +D K ++ A ++ +LDI + + L+ + DEILS E
Sbjct: 539 AIDSLDSKDPKHSHMK-------AQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEE 591
Query: 193 IVILSKQVEDLNVKC-QLLEKEKEDHVNRNREH------------NE--NLNAEMQNLKQ 237
I L +Q+ + + + L+K+ E ++ +E+ NE L E + L Q
Sbjct: 592 IKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQ 651
Query: 238 KFILEQQEREKLQ---------QKEL-QIDSLLQQEKELSSSLHQ---KLCSFQEEMVKE 284
+ +QER++L+ +KEL +++S LQ++ E+++SL Q L +++ E+
Sbjct: 652 RLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEAR 711
Query: 285 KNLFEEELKQTLDELDKLQ--------------QKEEQA--------------ERLVKQL 316
NL + E Q +EL+K+ +KE QA E+ +L
Sbjct: 712 LNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSEL 771
Query: 317 EEEAKSRAEELKLLEEKLKGKEAELE---------KSSAAHTQ----------ATLLLQE 357
+ K ++ LL+++LK + L + AA + +
Sbjct: 772 HAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHS 831
Query: 358 KYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATES 417
D + +SL D+ QF A + E ++ ++ LQE+ A +Q + LAT
Sbjct: 832 PSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMA--------LQQEKLAT-- 881
Query: 418 SNQEYVRMLLD--LQTKSALKETEIKEITVSFLQKITDLQNQLKQQEE-----DFRKQLE 470
QE R + L+ + + + + +I LQ LK EE D + Q
Sbjct: 882 -GQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEA 940
Query: 471 DEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE 530
DE EKE A+L E K +L E+ ++ + F L + ++ K+A+ A
Sbjct: 941 DE-----EKERILAQLRELEKKKKL--EDAKSQEQVFGLDKELKKL-KKAVATSDKLATA 992
Query: 531 QLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEEL 590
+L +D L G V+K+ E ++ E + + A+ + T+ + E+
Sbjct: 993 ELTIAKDQLKSLHG---------TVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEI 1043
Score = 76.6 bits (187), Expect = 6e-14
Identities = 117/519 (22%), Positives = 218/519 (42%), Gaps = 71/519 (13%)
Query: 11 ERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIE-LTRTNELLKSKFS 69
++ +++++ + + +++E+RL+ L + LE+QL E NE LK
Sbjct: 556 QKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLE 615
Query: 70 E--NGNQKNLRILS-------LELMKLRNKRET-----------------------KMRG 97
+G Q+ L + E KLR+++ET MR
Sbjct: 616 GVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRK 675
Query: 98 MMAKQEGMEMKLQVTQRSLEESQGKI----AQLEGKLVSIEKEKIDEKSETEKLLEYIE- 152
+A+ E + SL+++QG + A+LE +L + E K E EK+ +
Sbjct: 676 ELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQL 735
Query: 153 EISCASDQVEKYK------LDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVK 206
E S ++EK + L AQ E +++N E+ + + L+++ +L +Q++D
Sbjct: 736 EQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDF--- 792
Query: 207 CQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKEL 266
+ +HV E + A + L++K L E ++ SL +K+
Sbjct: 793 -----QNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQF 847
Query: 267 SSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQA-ERLV--------KQLE 317
S L + E V+E+ L +EE+ ++L Q++ QA ER + +Q E
Sbjct: 848 SEILARSKWERDEAQVRERKL-QEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHE 906
Query: 318 EEAKSRAEELKLLEEKLKGKE-----AELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQ 372
+ E+ L+E LK E +L+ A + +L Q + + LED +Q
Sbjct: 907 ARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQ 966
Query: 373 FESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESS-NQEYVRMLLDLQT 431
+ + E++ LK ++ + A A+D + T NQE L + +
Sbjct: 967 EQVFGL--DKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAER 1024
Query: 432 KSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLE 470
S +++T + + I LQN L+Q+ E FR ++E
Sbjct: 1025 FSRKAAQAARDLTRAEAE-IELLQNLLRQKGEQFRLEME 1062
Score = 72.0 bits (175), Expect = 2e-12
Identities = 118/541 (21%), Positives = 224/541 (41%), Gaps = 91/541 (16%)
Query: 115 SLEESQGKIAQLEGKLVSIEKEK------IDEKSETEKLLEYIEEISCASDQ-VEKYKLD 167
SLEE + LE K++ E+ K ++E +KL + ++E + Q E+ K D
Sbjct: 268 SLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSD 327
Query: 168 IAQLEENLKEKNDEILSLKQS---LEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREH 224
+ E LK+K E+ Q LE+ + ++ K + L ++ ++
Sbjct: 328 LNTKNELLKQKTIELTRACQKQYELEQELAFYK-----IDAKFEPLNYYPSEYAEIDKAP 382
Query: 225 NENLNAEMQNLKQKFILEQQ----EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEE 280
+E+ K+ + + +Q K+++ D L+ + ++ H L + E+
Sbjct: 383 DESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRND-HMNLRGHTPLDTQLED 441
Query: 281 MVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEE--EAKSRAEELK-LLEEKLKGK 337
K+ + + L + DE++K +Q+ +A KQLEE + K +E K LL ++L G+
Sbjct: 442 KEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGR 501
Query: 338 EAELEKSSAAHTQATLLLQEKYDSM-------------VQSLEDVTAQFESYKALTASEI 384
+ K L ++++ + + SL+ + KA + +
Sbjct: 502 LQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKE 561
Query: 385 EDLKLEN-------SSLQEKAAKAGKNAEDV--------QHQILATE----------SSN 419
+ L + N S L E ++ K E++ + QI A E S
Sbjct: 562 QQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGL 621
Query: 420 QEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQE------EDFRKQLEDEE 473
QEY+ + T++ + ++++ + LQ++T+++ + Q E E+ RK+L + E
Sbjct: 622 QEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELE 681
Query: 474 GRKAEKENTT--------------AELTEEIN----KWRLLYEELYNKTKPFQLQLDAFE 515
E+ AEL +N + L EEL T+ QL+ A +
Sbjct: 682 SALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQ 741
Query: 516 VEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQ 575
E L E A + L K + S K + L K+KH L+D+N+ LK ++ +
Sbjct: 742 AE---LEKERQALKNALGKAQFSEEKEQENSELHAKLKH---LQDDNNLLKQQLKDFQNH 795
Query: 576 L 576
L
Sbjct: 796 L 796
Score = 71.2 bits (173), Expect = 3e-12
Identities = 116/549 (21%), Positives = 233/549 (42%), Gaps = 72/549 (13%)
Query: 134 EKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS---LKQSLE 190
+KEK ++T +L E +EI A Q+ + + QLEE ++ K L + L
Sbjct: 441 DKEKKISAAQT-RLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLS 499
Query: 191 ENIVILSK-QVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKL 249
+ +++K + E L+++ Q+ EK+K++ + +E + L + +L K + +
Sbjct: 500 GRLQLVNKLRQEALDLELQM-EKQKQEIAGKQKEIKD-LQIAIDSLDSKDPKHSHMKAQK 557
Query: 250 QQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFE----------EELKQTLDE- 298
KE Q+D + +Q ++L S L + L +E + K+L E E LK+ L+
Sbjct: 558 SGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGV 617
Query: 299 -------LDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK-----LKGKEAELEKSSA 346
L ++ + QA+ ++L +E ++ + L +E++ + +AE +
Sbjct: 618 ISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKEL 677
Query: 347 AHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAE 406
A ++ L Q + ++ SL+ +Y+A + + E + L+E+ K + +
Sbjct: 678 AELESALQEQHEVNA---SLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQ 734
Query: 407 DVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFR 466
Q + A ++ ++ L S KE E E+ L+ + D N LKQQ +DF+
Sbjct: 735 LEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAK-LKHLQDDNNLLKQQLKDFQ 793
Query: 467 KQLEDEEGRKAEKENTTAELTEEINKWRL-------------LYEELYNKTKPF------ 507
L E A + E K +L L + L + K F
Sbjct: 794 NHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILAR 853
Query: 508 -QLQLDAFEVEKQALLNEHGAAQEQL----NKIRDSYAKLL---------GHQNLKQKIK 553
+ + D +V ++ L E QE+L + R + + L H+ Q+++
Sbjct: 854 SKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQME 913
Query: 554 HVVKLKDENSQLKSEVSKLR-CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKEN 612
+ + EN + E+ L QL + + + ++ +L ++ K + +K+ ++
Sbjct: 914 NEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKS----QEQV 969
Query: 613 FALKTPLKE 621
F L LK+
Sbjct: 970 FGLDKELKK 978
Score = 58.9 bits (141), Expect = 1e-08
Identities = 86/405 (21%), Positives = 175/405 (43%), Gaps = 74/405 (18%)
Query: 215 EDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELS---SSLH 271
E+ V+R + ++L ++ + + ++Q +++++ ID LLQ++K L LH
Sbjct: 1322 ENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELH 1381
Query: 272 QKLCSFQE--------------EMVKEKNL-FEEELKQTLDELDK--LQQKEE--QAERL 312
+ + Q+ E+ EK+L E++ ++ ++K L+++ E +A+RL
Sbjct: 1382 RTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRL 1441
Query: 313 VKQLEEEAKSRAEELKLLEEKL-KGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTA 371
+ + E E E+ K EK K + L+ S A L+ + +L
Sbjct: 1442 LAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEE-----LERRAQETAVNLVKADQ 1496
Query: 372 QFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQT 431
Q S +A A ++E K++ + ++ K I+A + S D Q
Sbjct: 1497 QLRSLQA-DAKDLEQHKIKQEEILKEINK-----------IVAAKDS---------DFQC 1535
Query: 432 KSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEE----GRKAEKENTTAELT 487
S KE +E LQK+ ++ E+ + L++ E ++AE E +++T
Sbjct: 1536 LSKKKEKLTEE-----LQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVT 1590
Query: 488 EEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN 547
+ + +L +L +K + L L V+ +A L E A LG
Sbjct: 1591 SQQQEMAVLDRQLGHKKEELHL-LQGSMVQAKADLQE---------------ALRLGETE 1634
Query: 548 LKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNK 592
+ +K H+ ++K +L + +L Q++++K T +++E+ K
Sbjct: 1635 VTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEK 1679
Score = 30.0 bits (66), Expect = 6.8
Identities = 26/142 (18%), Positives = 61/142 (42%), Gaps = 14/142 (9%)
Query: 453 DLQNQLKQQEE---DFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQL 509
+L+N++ + E+ + + +E +A K + E+ EEL++
Sbjct: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEM-----------EELHHNIDDLLQ 1368
Query: 510 QLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEV 569
+ + E E + L Q+Q + I + L+ +++ +KH + DE ++ +
Sbjct: 1369 EKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTL 1428
Query: 570 SKLRCQLAKKKQSETKLQEELN 591
K R +L + + + + EL+
Sbjct: 1429 LKRRSELREADRLLAEAESELS 1450
>gi|34577114 cytomatrix protein p110 [Homo sapiens]
Length = 957
Score = 108 bits (269), Expect = 2e-23
Identities = 160/710 (22%), Positives = 307/710 (43%), Gaps = 101/710 (14%)
Query: 6 RVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLK 65
R L E Q + + L LE+ME R+ +K +L+A + +++K L+E+ ++ L
Sbjct: 264 RRLQAEHDRQAKELFLLRKTLEEMELRIET---QKQTLNARDESIKK-LLEMLQSKGL-P 318
Query: 66 SKFSENGNQKNLRILSLE--------LMKLRNKRETKMRGMMAKQEGME---MKLQVTQR 114
SK E+ N++ R+ E ++ + K +R + ++ ++ K + Q
Sbjct: 319 SKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQT 378
Query: 115 SLEESQGKIAQLEGKLVSIEKE----KIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQ 170
+E KIA LE + +E E K + TE E I++I + K I Q
Sbjct: 379 VIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQ 438
Query: 171 LEENLKEKNDEILSLKQSLE----------ENIVILSKQVEDLNVKCQLLE--------- 211
L++ L +K E+L+L+ LE ++I +L + + + +L+
Sbjct: 439 LKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLR 498
Query: 212 -KEKEDHVNRNREHNENLNAEMQNLK-----QKFILEQQERE--KLQQKELQIDSLLQQE 263
+EKE +N+ + ++L E L K +LE +ER+ LQ+K + L+ +
Sbjct: 499 LEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDK 558
Query: 264 KELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQK-EEQAERLVKQLEEEAKS 322
+ ++L ++ S Q + L++ L E +++ ++ +EQ ER ++ EE +S
Sbjct: 559 DKQLTNLKDRVKSLQTDSSNTDTALAT-LEEALSEKERIIERLKEQRERDDRERLEEIES 617
Query: 323 RAEELKLLEEKLKGKEAEL-EKSSAA-----HTQATLLLQEKYDSMVQSLEDVTAQFESY 376
+E K L+EK+ +AEL EK S+ H + K DS ++SLE Q +
Sbjct: 618 FRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEE 677
Query: 377 ------KALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQ 430
+ A IED N ++ + K A + + ++ + +L +++
Sbjct: 678 CSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVE 737
Query: 431 TKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEI 490
+ K+ +I E+ L+ + D ++ + + +QLE ++ + +E E +
Sbjct: 738 NEKNDKDKKIAELESLTLRHMKDQNKKVANLKHN--QQLEKKKNAQLLEEVRRREDSMAD 795
Query: 491 NKWRLLYEELYNKTKPFQLQLDAFE----------VEKQA-LLNEHGAAQEQLNKI---- 535
N L EEL N + + +LDA + EK+A L N ++QL +I
Sbjct: 796 NSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMK 855
Query: 536 ----------RDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETK 585
+D+ LL K+K K ++E LK E +L QL ++ Q+ K
Sbjct: 856 QEALLAAISEKDANIALLELSASKKK-----KTQEEVMALKREKDRLVHQLKQQTQNRMK 910
Query: 586 LQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQE 635
L + ++D +H + ++P + ++N +P + E
Sbjct: 911 LMAD--------NYDDDHHHYHHHHHHHHHRSPGRSQHSNHRPSPDQDDE 952
Score = 91.3 bits (225), Expect = 2e-18
Identities = 136/618 (22%), Positives = 255/618 (41%), Gaps = 109/618 (17%)
Query: 50 LEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKL 109
L+ QL EL R N+LL+ + ++ S+ +K E K ++ K+E M
Sbjct: 150 LQAQLKELQRENDLLRKELDIKDSKLGS---SMNSIKTFWSPELKKERVLRKEEAARM-- 204
Query: 110 QVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIA 169
S+ + Q +++ E + + + + + ++ T++ L ++ + + E + +++
Sbjct: 205 -----SVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELT 259
Query: 170 QLEEN---LKEKND----EILSLKQSLEENIVILSKQVEDLNVKCQ----LLE------- 211
EEN L+ ++D E+ L+++LEE + + Q + LN + + LLE
Sbjct: 260 --EENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGL 317
Query: 212 --KEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQ-QKELQIDSLLQQEKELSS 268
K ED R R E AE Q + IL+Q+E+E + ++EL S LQ E +
Sbjct: 318 PSKSLEDDNERTRRMAE---AESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTK 374
Query: 269 SLHQ-------KLCSFQE---------EMVKEKNLFE-EELKQTLDELDKLQQKEEQAER 311
+L K+ S + +M+K + E+ ++ + +++ + + +
Sbjct: 375 ALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKT 434
Query: 312 LVKQLEEEAKSRAEELKLLEEKLKGKEAE----------LEKSSAAHTQATLLLQEKYDS 361
+ QL++E + EL L+ KL+ + L++S A Q +LQ + D+
Sbjct: 435 KIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDA 494
Query: 362 MVQSLEDV-------TAQFESY---KALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQ 411
+ LE+ T Q + K A EI D+K + K K E++Q Q
Sbjct: 495 LRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQ 554
Query: 412 ILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLED 471
+ + + LQT S+ +T + + + +K ++ +Q+E D R++LE+
Sbjct: 555 LRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEE 614
Query: 472 EEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQAL-LNEHGAAQE 530
E + E + +L E++N LQ + E E + L EH ++
Sbjct: 615 IESFRKENK----DLKEKVN----------------ALQAELTEKESSLIDLKEHASSLA 654
Query: 531 QLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEEL 590
RDS K L+ Q K E SKL QL K E +
Sbjct: 655 SAGLKRDSKLK---------------SLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNP 699
Query: 591 NKVLGIKHFDPSKAFHHE 608
IK D +++ +
Sbjct: 700 EFADQIKQLDKEASYYRD 717
Score = 62.8 bits (151), Expect = 9e-10
Identities = 94/479 (19%), Positives = 200/479 (41%), Gaps = 83/479 (17%)
Query: 2 TLLIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN 61
T ++ L +E+G I+D++ LE E ++N L+K++ L
Sbjct: 510 TKQLQDLTEEKGTLAGEIRDMKDMLEVKERKIN--------------VLQKKIENL---- 551
Query: 62 ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG 121
Q+ LR +L L++ +++ + + L + +L E +
Sbjct: 552 ------------QEQLRDKDKQLTNLKD----RVKSLQTDSSNTDTALATLEEALSEKER 595
Query: 122 KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEE---NLKEK 178
I +L+ E+ + D++ E++ + +E ++V + ++ + E +LKE
Sbjct: 596 IIERLK------EQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEH 649
Query: 179 NDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE-KEDHVNRNREHNENLNAEM-QNLK 236
+ S + + L +E +C LE + K+ H N E + +N E +K
Sbjct: 650 ASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAH---NIEDDSRMNPEFADQIK 706
Query: 237 QKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL 296
Q R++ + + ++D LL+ KE+ + E+ K+K + E L
Sbjct: 707 QLDKEASYYRDECGKAQAEVDRLLEILKEVEN----------EKNDKDKKIAE------L 750
Query: 297 DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQ 356
+ L L+ ++Q +++ + + + +LLEE + +++ + S H Q
Sbjct: 751 ESL-TLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQ--HLQ------ 801
Query: 357 EKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDV----QHQI 412
+ ++ +LE + ++ KA AS + L + + L + K E++ Q +
Sbjct: 802 --IEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEAL 859
Query: 413 LATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLED 471
LA S + +L SA K+ + +E ++ ++ L +QLKQQ ++ K + D
Sbjct: 860 LAAISEKDANIALL----ELSASKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLMAD 914
Score = 45.1 bits (105), Expect = 2e-04
Identities = 51/229 (22%), Positives = 105/229 (45%), Gaps = 35/229 (15%)
Query: 4 LIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEK----QLIELTR 59
+++ + E+ +D++I ELE + R +K + +N LEK QL+E R
Sbjct: 732 ILKEVENEKNDKDKKI----AELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVR 787
Query: 60 TNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEES 119
E S N ++L+I ELM K ++ + + +L TQ+SL E
Sbjct: 788 RRE-----DSMADNSQHLQIE--ELMNALEKTRQEL-------DATKARLASTQQSLAEK 833
Query: 120 QGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEK- 178
+ +A L +I+ + + E++LE +E A+ + + + +L + K+K
Sbjct: 834 EAHLANL----------RIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKT 883
Query: 179 NDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNEN 227
+E+++LK+ + + L +Q + N + + +DH + + H+ +
Sbjct: 884 QEEVMALKREKDRLVHQLKQQTQ--NRMKLMADNYDDDHHHYHHHHHHH 930
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.124 0.313
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,714,684
Number of Sequences: 37866
Number of extensions: 997160
Number of successful extensions: 31218
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 729
Number of HSP's successfully gapped in prelim test: 1467
Number of HSP's that attempted gapping in prelim test: 7775
Number of HSP's gapped (non-prelim): 8695
length of query: 638
length of database: 18,247,518
effective HSP length: 109
effective length of query: 529
effective length of database: 14,120,124
effective search space: 7469545596
effective search space used: 7469545596
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.