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Search of human proteins with 21614507
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21614507 cytokine-inducible SH2-containing protein isoform 2
[Homo sapiens]
(258 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21614507 cytokine-inducible SH2-containing protein isoform 2 ... 527 e-150
gi|195976771 cytokine-inducible SH2-containing protein isoform 1... 513 e-146
gi|4507263 suppressor of cytokine signaling-2 [Homo sapiens] 159 3e-39
gi|45439352 suppressor of cytokine signaling 3 [Homo sapiens] 105 5e-23
gi|21450785 suppressor of cytokine signaling 6 [Homo sapiens] 84 1e-16
gi|4507233 suppressor of cytokine signaling 1 [Homo sapiens] 77 2e-14
gi|53831997 suppressor of cytokine signaling 7 [Homo sapiens] 76 3e-14
gi|40807480 suppressor of cytokine signaling 4 [Homo sapiens] 74 1e-13
gi|18254466 suppressor of cytokine signaling 4 [Homo sapiens] 74 1e-13
gi|21618354 suppressor of cytokine signaling 5 [Homo sapiens] 68 7e-12
gi|7662240 suppressor of cytokine signaling 5 [Homo sapiens] 68 7e-12
gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta... 55 5e-08
gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 54 1e-07
gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 54 1e-07
gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 49 3e-06
gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 49 3e-06
gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 49 3e-06
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit... 42 7e-04
gi|187475373 c-src tyrosine kinase [Homo sapiens] 41 0.001
gi|4758078 c-src tyrosine kinase [Homo sapiens] 41 0.001
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 41 0.001
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 41 0.001
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 41 0.001
gi|111074524 Src homology 2 domain containing F [Homo sapiens] 41 0.001
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 40 0.002
gi|58219064 Src homology 2 domain containing E [Homo sapiens] 40 0.002
gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a ... 40 0.003
gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b ... 40 0.003
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 39 0.003
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] 39 0.003
>gi|21614507 cytokine-inducible SH2-containing protein isoform 2
[Homo sapiens]
Length = 258
Score = 527 bits (1358), Expect = e-150
Identities = 258/258 (100%), Positives = 258/258 (100%)
Query: 1 MVLCVQGPRPLLAVERTGQRPLWAPSLELPKPVMQPLPAGAFLEEVAEGTPAQTESEPKV 60
MVLCVQGPRPLLAVERTGQRPLWAPSLELPKPVMQPLPAGAFLEEVAEGTPAQTESEPKV
Sbjct: 1 MVLCVQGPRPLLAVERTGQRPLWAPSLELPKPVMQPLPAGAFLEEVAEGTPAQTESEPKV 60
Query: 61 LDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSV 120
LDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSV
Sbjct: 61 LDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSV 120
Query: 121 KTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAP 180
KTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAP
Sbjct: 121 KTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAP 180
Query: 181 TPALPMPKEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVADVDC 240
TPALPMPKEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVADVDC
Sbjct: 181 TPALPMPKEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVADVDC 240
Query: 241 LPLPRRMADYLRQYPFQL 258
LPLPRRMADYLRQYPFQL
Sbjct: 241 LPLPRRMADYLRQYPFQL 258
>gi|195976771 cytokine-inducible SH2-containing protein isoform 1
[Homo sapiens]
Length = 275
Score = 513 bits (1321), Expect = e-146
Identities = 251/251 (100%), Positives = 251/251 (100%)
Query: 8 PRPLLAVERTGQRPLWAPSLELPKPVMQPLPAGAFLEEVAEGTPAQTESEPKVLDPEEDL 67
PRPLLAVERTGQRPLWAPSLELPKPVMQPLPAGAFLEEVAEGTPAQTESEPKVLDPEEDL
Sbjct: 25 PRPLLAVERTGQRPLWAPSLELPKPVMQPLPAGAFLEEVAEGTPAQTESEPKVLDPEEDL 84
Query: 68 LCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPT 127
LCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPT
Sbjct: 85 LCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPT 144
Query: 128 NVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMP 187
NVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMP
Sbjct: 145 NVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMP 204
Query: 188 KEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVADVDCLPLPRRM 247
KEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVADVDCLPLPRRM
Sbjct: 205 KEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVADVDCLPLPRRM 264
Query: 248 ADYLRQYPFQL 258
ADYLRQYPFQL
Sbjct: 265 ADYLRQYPFQL 275
>gi|4507263 suppressor of cytokine signaling-2 [Homo sapiens]
Length = 198
Score = 159 bits (401), Expect = 3e-39
Identities = 88/211 (41%), Positives = 118/211 (55%), Gaps = 26/211 (12%)
Query: 48 EGTPAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVR 107
EGT +Q + +P +AK L ++GWYWGS+T +EA++ L++ PEGTFL+R
Sbjct: 14 EGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIR 73
Query: 108 DSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASC 167
DS+H YL T+SVKT+ GPTN+RIEY D FRLDS + ++ F VV L+ +YV C
Sbjct: 74 DSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMC 133
Query: 168 TADTRSDSPDPAPTPALPMPKEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLC 227
D R+ P P VHL L +P +SA SLQHLC
Sbjct: 134 -KDKRTG-----------------------PEAPRNGTVHLYLTKPLY--TSAPSLQHLC 167
Query: 228 RLVINRLVADVDCLPLPRRMADYLRQYPFQL 258
RL IN+ + LPLP R+ DYL +Y FQ+
Sbjct: 168 RLTINKCTGAIWGLPLPTRLKDYLEEYKFQV 198
>gi|45439352 suppressor of cytokine signaling 3 [Homo sapiens]
Length = 225
Score = 105 bits (261), Expect = 5e-23
Identities = 71/212 (33%), Positives = 101/212 (47%), Gaps = 13/212 (6%)
Query: 51 PAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDST 110
P T K + + + L+ESG+YW ++T EA L P GTFL+RDS+
Sbjct: 15 PLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSS 74
Query: 111 HPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTAD 170
+ FTLSVKT G N+RI+ SF L S+ S + F V+ LV HY+ A
Sbjct: 75 DQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGAP 134
Query: 171 TRSDSPDPAPTPALPMPKEDAPSDPALPAPPPATAVH-------LKLVQPFVRRSSARSL 223
+ P P P+ +P++ PS LP PP A + + LV S+ +L
Sbjct: 135 S---FPSPPTEPSSEVPEQ--PSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLSSNVATL 189
Query: 224 QHLCRLVIN-RLVADVDCLPLPRRMADYLRQY 254
QHLCR +N L + LP + ++L QY
Sbjct: 190 QHLCRKTVNGHLDSYEKVTQLPGPIREFLDQY 221
>gi|21450785 suppressor of cytokine signaling 6 [Homo sapiens]
Length = 535
Score = 84.0 bits (206), Expect = 1e-16
Identities = 54/179 (30%), Positives = 84/179 (46%), Gaps = 27/179 (15%)
Query: 77 LRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADS 136
L + GWYWG IT EA L +P+G+FLVRDS+ YL +LS ++ + RIE+++
Sbjct: 379 LAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNG 438
Query: 137 SFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMPKEDAPSDPA 196
F + +P + +V L++H + + A + P
Sbjct: 439 RF----SFYEQPDVEGHTSIVDLIEHSIRD------------SENGAFCYSRSRLPGSAT 482
Query: 197 LPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVINRL--VADVDCLPLPRRMADYLRQ 253
P ++L P R RSLQ+LCR VI + + + LPLP +M DYL++
Sbjct: 483 YP---------VRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQE 532
>gi|4507233 suppressor of cytokine signaling 1 [Homo sapiens]
Length = 211
Score = 76.6 bits (187), Expect = 2e-14
Identities = 62/213 (29%), Positives = 88/213 (41%), Gaps = 54/213 (25%)
Query: 51 PAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDST 110
PA ++ + D I + + L G+YWG ++ A + L+ P GTFLVRDS
Sbjct: 48 PAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSR 107
Query: 111 HPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTAD 170
+ F LSVK GPT++R+ + F LD + S F + L++HYVA
Sbjct: 108 QRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRES------FDCLFELLEHYVA----- 156
Query: 171 TRSDSPDPAPTPALPMPKEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLV 230
AP L P +R+ R LQ LCR
Sbjct: 157 --------APRRMLGAP---------------------------LRQRRVRPLQELCR-- 179
Query: 231 INRLVADVD-----CLPLPRRMADYLRQYPFQL 258
R+VA V +PL + DYL +PFQ+
Sbjct: 180 -QRIVATVGRENLARIPLNPVLRDYLSSFPFQI 211
>gi|53831997 suppressor of cytokine signaling 7 [Homo sapiens]
Length = 581
Score = 76.3 bits (186), Expect = 3e-14
Identities = 54/191 (28%), Positives = 89/191 (46%), Gaps = 25/191 (13%)
Query: 66 DLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRG 125
D A + L + GWYWG + +A L+ P+G+FLVRDS+ P Y+ +LS ++
Sbjct: 384 DSSSFAASLRELEKCGWYWGPMNWEDAEMKLKGKPDGSFLVRDSSDPRYILSLSFRSQGI 443
Query: 126 PTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALP 185
+ R+E+ +F L P+ F D V ++ +++ L
Sbjct: 444 THHTRMEHYRGTFSL----WCHPK---FEDRCQSVVEFIKRAIMHSKNGK-------FLY 489
Query: 186 MPKEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVA--DVDCLPL 243
+ P P P ++L+ P R S+ +SLQHLCR I +LV + LPL
Sbjct: 490 FLRSRVPGLPPTP---------VQLLYPVSRFSNVKSLQHLCRFRIRQLVRIDHIPDLPL 540
Query: 244 PRRMADYLRQY 254
P+ + Y+R++
Sbjct: 541 PKPLISYIRKF 551
>gi|40807480 suppressor of cytokine signaling 4 [Homo sapiens]
Length = 440
Score = 74.3 bits (181), Expect = 1e-13
Identities = 56/207 (27%), Positives = 88/207 (42%), Gaps = 40/207 (19%)
Query: 53 QTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHP 112
Q E+ PK + + C+ + + YWG + A L+ PEGTFL+RDS
Sbjct: 257 QLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQE 316
Query: 113 SYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTR 172
YLF++S + + RIE + +F D++ P + PD+ L++HY
Sbjct: 317 DYLFSVSFRRYSRSLHARIEQWNHNFSFDAH---DPCVFHSPDITGLLEHY--------- 364
Query: 173 SDSPDPAPTPALPMPKEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVIN 232
DP+ +P L P + R+ SLQH+CR VI
Sbjct: 365 ---KDPSACMFF---------EPLLSTP--------------LIRTFPFSLQHICRTVIC 398
Query: 233 RLVA--DVDCLPLPRRMADYLRQYPFQ 257
+D LP+P M YL++Y ++
Sbjct: 399 NCTTYDGIDALPIPSSMKLYLKEYHYK 425
>gi|18254466 suppressor of cytokine signaling 4 [Homo sapiens]
Length = 440
Score = 74.3 bits (181), Expect = 1e-13
Identities = 56/207 (27%), Positives = 88/207 (42%), Gaps = 40/207 (19%)
Query: 53 QTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHP 112
Q E+ PK + + C+ + + YWG + A L+ PEGTFL+RDS
Sbjct: 257 QLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQE 316
Query: 113 SYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTR 172
YLF++S + + RIE + +F D++ P + PD+ L++HY
Sbjct: 317 DYLFSVSFRRYSRSLHARIEQWNHNFSFDAH---DPCVFHSPDITGLLEHY--------- 364
Query: 173 SDSPDPAPTPALPMPKEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVIN 232
DP+ +P L P + R+ SLQH+CR VI
Sbjct: 365 ---KDPSACMFF---------EPLLSTP--------------LIRTFPFSLQHICRTVIC 398
Query: 233 RLVA--DVDCLPLPRRMADYLRQYPFQ 257
+D LP+P M YL++Y ++
Sbjct: 399 NCTTYDGIDALPIPSSMKLYLKEYHYK 425
>gi|21618354 suppressor of cytokine signaling 5 [Homo sapiens]
Length = 536
Score = 68.2 bits (165), Expect = 7e-12
Identities = 52/191 (27%), Positives = 80/191 (41%), Gaps = 40/191 (20%)
Query: 69 CIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTN 128
C+ + + YWG + EA L+ PEGTFL+RDS YLF++S + +
Sbjct: 368 CLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLH 427
Query: 129 VRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMPK 188
RIE + +F D++ P + V L++HY DP+
Sbjct: 428 ARIEQWNHNFSFDAH---DPCVFHSSTVTGLLEHY------------KDPSSCMFF---- 468
Query: 189 EDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVA--DVDCLPLPRR 246
P + L PF SLQ++CR VI R +D LPLP
Sbjct: 469 ------------EPLLTISLNRTFPF-------SLQYICRAVICRCTTYDGIDGLPLPSM 509
Query: 247 MADYLRQYPFQ 257
+ D+L++Y ++
Sbjct: 510 LQDFLKEYHYK 520
>gi|7662240 suppressor of cytokine signaling 5 [Homo sapiens]
Length = 536
Score = 68.2 bits (165), Expect = 7e-12
Identities = 52/191 (27%), Positives = 80/191 (41%), Gaps = 40/191 (20%)
Query: 69 CIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTN 128
C+ + + YWG + EA L+ PEGTFL+RDS YLF++S + +
Sbjct: 368 CLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLH 427
Query: 129 VRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMPK 188
RIE + +F D++ P + V L++HY DP+
Sbjct: 428 ARIEQWNHNFSFDAH---DPCVFHSSTVTGLLEHY------------KDPSSCMFF---- 468
Query: 189 EDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVA--DVDCLPLPRR 246
P + L PF SLQ++CR VI R +D LPLP
Sbjct: 469 ------------EPLLTISLNRTFPF-------SLQYICRAVICRCTTYDGIDGLPLPSM 509
Query: 247 MADYLRQYPFQ 257
+ D+L++Y ++
Sbjct: 510 LQDFLKEYHYK 520
>gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
[Homo sapiens]
Length = 728
Score = 55.5 bits (132), Expect = 5e-08
Identities = 42/140 (30%), Positives = 66/140 (47%), Gaps = 10/140 (7%)
Query: 25 PSLELPKPVMQPLPAGAFLEEVAEGTPAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYW 84
PS + P +++ L LEE PA PK P +L + L+++ WYW
Sbjct: 275 PSPDFPALLVEKL-LQEHLEEQEVAPPALPPKPPKA-KPAPTVLANGGSPPSLQDAEWYW 332
Query: 85 GSITASEARQHLQKMPEGTFLVRD-STHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSN 143
G I+ E + L+ P+GTFLVRD S+ +TL+++ +++ + D +
Sbjct: 333 GDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYG---- 388
Query: 144 CLSRPRILAFPDVVSLVQHY 163
S P L F VV L+ HY
Sbjct: 389 -FSEP--LTFCSVVDLINHY 405
Score = 37.4 bits (85), Expect = 0.013
Identities = 39/140 (27%), Positives = 61/140 (43%), Gaps = 14/140 (10%)
Query: 49 GTPAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRD 108
G +TE + +++ E+DL + E WY G I ++A + L +GTFL+R+
Sbjct: 596 GIKNETEDQYALMEDEDDL-------PHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRE 648
Query: 109 STHPSYLFTLSVKTTRGPTNVRIEYADSS---FRLDSNCL-SRPRILAFPDVVSLVQHYV 164
S+ + SV G T + Y ++ F N S ++ SLVQH
Sbjct: 649 SSQRG-CYACSV-VVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHND 706
Query: 165 A-SCTADTRSDSPDPAPTPA 183
A + T +P P P PA
Sbjct: 707 ALTVTLAHPVRAPGPGPPPA 726
>gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 53.9 bits (128), Expect = 1e-07
Identities = 30/88 (34%), Positives = 45/88 (51%), Gaps = 8/88 (9%)
Query: 77 LRESGWYWGSITASEARQHLQKMPEGTFLVRD-STHPSYLFTLSVKTTRGPTNVRIEYAD 135
L+++ WYWG I+ E L+ MP+GTFLVRD ST +TL+++ ++I + D
Sbjct: 60 LQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRD 119
Query: 136 SSFRLDSNCLSRPRILAFPDVVSLVQHY 163
+ L F VV L+ HY
Sbjct: 120 GKYGFSDP-------LTFNSVVELINHY 140
>gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 53.9 bits (128), Expect = 1e-07
Identities = 30/88 (34%), Positives = 45/88 (51%), Gaps = 8/88 (9%)
Query: 77 LRESGWYWGSITASEARQHLQKMPEGTFLVRD-STHPSYLFTLSVKTTRGPTNVRIEYAD 135
L+++ WYWG I+ E L+ MP+GTFLVRD ST +TL+++ ++I + D
Sbjct: 60 LQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRD 119
Query: 136 SSFRLDSNCLSRPRILAFPDVVSLVQHY 163
+ L F VV L+ HY
Sbjct: 120 GKYGFSDP-------LTFNSVVELINHY 140
>gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 2 [Homo sapiens]
Length = 454
Score = 49.3 bits (116), Expect = 3e-06
Identities = 30/92 (32%), Positives = 45/92 (48%), Gaps = 16/92 (17%)
Query: 77 LRESGWYWGSITASEARQHLQKMPEGTFLVRDST---HPSYLFTLSVKTTRGPTN--VRI 131
L+++ WYWG I+ E + L+ +GTFLVRD++ H Y TL +G N ++I
Sbjct: 58 LQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTL----RKGGNNKLIKI 113
Query: 132 EYADSSFRLDSNCLSRPRILAFPDVVSLVQHY 163
+ D + L F VV L+ HY
Sbjct: 114 FHRDGKYGFSDP-------LTFSSVVELINHY 138
Score = 29.6 bits (65), Expect = 2.7
Identities = 18/57 (31%), Positives = 30/57 (52%), Gaps = 7/57 (12%)
Query: 54 TESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDST 110
TE + +++ +EDL + E W GS ++A L+ +GTFLVR+S+
Sbjct: 333 TEDQYSLVEDDEDL-------PHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESS 382
>gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 3 [Homo sapiens]
Length = 424
Score = 49.3 bits (116), Expect = 3e-06
Identities = 30/92 (32%), Positives = 45/92 (48%), Gaps = 16/92 (17%)
Query: 77 LRESGWYWGSITASEARQHLQKMPEGTFLVRDST---HPSYLFTLSVKTTRGPTN--VRI 131
L+++ WYWG I+ E + L+ +GTFLVRD++ H Y TL +G N ++I
Sbjct: 28 LQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTL----RKGGNNKLIKI 83
Query: 132 EYADSSFRLDSNCLSRPRILAFPDVVSLVQHY 163
+ D + L F VV L+ HY
Sbjct: 84 FHRDGKYGFSDP-------LTFSSVVELINHY 108
Score = 29.6 bits (65), Expect = 2.7
Identities = 18/57 (31%), Positives = 30/57 (52%), Gaps = 7/57 (12%)
Query: 54 TESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDST 110
TE + +++ +EDL + E W GS ++A L+ +GTFLVR+S+
Sbjct: 303 TEDQYSLVEDDEDL-------PHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESS 352
>gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 1 [Homo sapiens]
Length = 724
Score = 49.3 bits (116), Expect = 3e-06
Identities = 30/92 (32%), Positives = 45/92 (48%), Gaps = 16/92 (17%)
Query: 77 LRESGWYWGSITASEARQHLQKMPEGTFLVRDST---HPSYLFTLSVKTTRGPTN--VRI 131
L+++ WYWG I+ E + L+ +GTFLVRD++ H Y TL +G N ++I
Sbjct: 328 LQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTL----RKGGNNKLIKI 383
Query: 132 EYADSSFRLDSNCLSRPRILAFPDVVSLVQHY 163
+ D + L F VV L+ HY
Sbjct: 384 FHRDGKYGFSDP-------LTFSSVVELINHY 408
Score = 29.6 bits (65), Expect = 2.7
Identities = 18/57 (31%), Positives = 30/57 (52%), Gaps = 7/57 (12%)
Query: 54 TESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDST 110
TE + +++ +EDL + E W GS ++A L+ +GTFLVR+S+
Sbjct: 603 TEDQYSLVEDDEDL-------PHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESS 652
>gi|158631203 dual adaptor of phosphotyrosine and
3-phosphoinositides [Homo sapiens]
Length = 280
Score = 41.6 bits (96), Expect = 7e-04
Identities = 22/68 (32%), Positives = 37/68 (54%), Gaps = 1/68 (1%)
Query: 77 LRESGWYWGSITASEARQHLQKMP-EGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYAD 135
L++ GWY G++T A L +G++L+RDS + L++LSV+ + +EY
Sbjct: 30 LQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTG 89
Query: 136 SSFRLDSN 143
SF+ N
Sbjct: 90 YSFKFGFN 97
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 41.2 bits (95), Expect = 0.001
Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 7/84 (8%)
Query: 82 WYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLD 141
W+ G IT +A + L G FLVR+ST+ +TL V + RI Y S +D
Sbjct: 82 WFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSID 141
Query: 142 SNCLSRPRILAFPDVVSLVQHYVA 165
+ F +++ LV+HY +
Sbjct: 142 EE-------VYFENLMQLVEHYTS 158
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 41.2 bits (95), Expect = 0.001
Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 7/84 (8%)
Query: 82 WYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLD 141
W+ G IT +A + L G FLVR+ST+ +TL V + RI Y S +D
Sbjct: 82 WFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSID 141
Query: 142 SNCLSRPRILAFPDVVSLVQHYVA 165
+ F +++ LV+HY +
Sbjct: 142 EE-------VYFENLMQLVEHYTS 158
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 41.2 bits (95), Expect = 0.001
Identities = 24/82 (29%), Positives = 39/82 (47%), Gaps = 7/82 (8%)
Query: 82 WYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLD 141
W+ G I+ EA Q LQ +G FLVR+S + L V R + R+ + D +D
Sbjct: 81 WFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTID 140
Query: 142 SNCLSRPRILAFPDVVSLVQHY 163
+ F +++ +V+HY
Sbjct: 141 -------EAVFFCNLMDMVEHY 155
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 41.2 bits (95), Expect = 0.001
Identities = 24/82 (29%), Positives = 39/82 (47%), Gaps = 7/82 (8%)
Query: 82 WYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLD 141
W+ G I+ EA Q LQ +G FLVR+S + L V R + R+ + D +D
Sbjct: 123 WFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTID 182
Query: 142 SNCLSRPRILAFPDVVSLVQHY 163
+ F +++ +V+HY
Sbjct: 183 -------EAVFFCNLMDMVEHY 197
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 41.2 bits (95), Expect = 0.001
Identities = 24/82 (29%), Positives = 39/82 (47%), Gaps = 7/82 (8%)
Query: 82 WYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLD 141
W+ G I+ EA Q LQ +G FLVR+S + L V R + R+ + D +D
Sbjct: 122 WFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTID 181
Query: 142 SNCLSRPRILAFPDVVSLVQHY 163
+ F +++ +V+HY
Sbjct: 182 -------EAVFFCNLMDMVEHY 196
>gi|111074524 Src homology 2 domain containing F [Homo sapiens]
Length = 423
Score = 40.8 bits (94), Expect = 0.001
Identities = 39/166 (23%), Positives = 71/166 (42%), Gaps = 26/166 (15%)
Query: 18 GQRPLWAPSLELPKPVMQPLPA-----------------GAFLEEVAEGTPAQTESEPKV 60
G R + P+ LP+P ++ A G ++ G P ++P
Sbjct: 244 GDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKS--AKPLS 301
Query: 61 LDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSV 120
++P L L WY G+I+ ++A L+ E ++LVR+S F+LS+
Sbjct: 302 MEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSL 361
Query: 121 KTTRGPTNVRIEYA-DSSFRLDSNCLSRPRILAFPDVVSLVQHYVA 165
K+++G ++++ + + L N S P F V +V HY +
Sbjct: 362 KSSQGFMHMKLSRTKEHKYVLGQN--SPP----FSSVPEIVHHYAS 401
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 40.4 bits (93), Expect = 0.002
Identities = 26/87 (29%), Positives = 43/87 (49%), Gaps = 10/87 (11%)
Query: 77 LRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADS 136
L E WY G+I EA++ L+K +G FLVR+S + LSV + + I+Y D+
Sbjct: 455 LAEQDWYHGAIPRIEAQELLKK--QGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDN 512
Query: 137 SFRLDSNCLSRPRILAFPDVVSLVQHY 163
+R + F ++ L+ H+
Sbjct: 513 MYRFEGT--------GFSNIPQLIDHH 531
>gi|58219064 Src homology 2 domain containing E [Homo sapiens]
Length = 495
Score = 40.0 bits (92), Expect = 0.002
Identities = 22/88 (25%), Positives = 46/88 (52%), Gaps = 7/88 (7%)
Query: 77 LRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRI-EYAD 135
L + WY G+I+ +EA LQ E +LVR+S + +++++KT++G ++ + + D
Sbjct: 390 LEKQPWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTKD 449
Query: 136 SSFRLDSNCLSRPRILAFPDVVSLVQHY 163
+ + L+ F + +V +Y
Sbjct: 450 NKYTLNQTS------AVFDSIPEVVHYY 471
>gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a
[Homo sapiens]
Length = 304
Score = 39.7 bits (91), Expect = 0.003
Identities = 21/51 (41%), Positives = 26/51 (50%)
Query: 70 IAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSV 120
+A F S WYWG ++ EA LQ G FLVRDS+ + LSV
Sbjct: 1 MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSV 51
>gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b
[Homo sapiens]
Length = 204
Score = 39.7 bits (91), Expect = 0.003
Identities = 21/51 (41%), Positives = 26/51 (50%)
Query: 70 IAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSV 120
+A F S WYWG ++ EA LQ G FLVRDS+ + LSV
Sbjct: 1 MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSV 51
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 39.3 bits (90), Expect = 0.003
Identities = 24/83 (28%), Positives = 45/83 (54%), Gaps = 9/83 (10%)
Query: 82 WYWGSITASEARQHL-QKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRL 140
WY+G++T +A L ++ EG FL+RDS F++S+K + + +++ D+ +
Sbjct: 285 WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLVDNVY-- 342
Query: 141 DSNCLSRPRILAFPDVVSLVQHY 163
C+ + R F + LV+HY
Sbjct: 343 ---CIGQRR---FHTMDELVEHY 359
>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 39.3 bits (90), Expect = 0.003
Identities = 24/83 (28%), Positives = 45/83 (54%), Gaps = 9/83 (10%)
Query: 82 WYWGSITASEARQHL-QKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRL 140
WY+G++T +A L ++ EG FL+RDS F++S+K + + +++ D+ +
Sbjct: 285 WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLVDNVY-- 342
Query: 141 DSNCLSRPRILAFPDVVSLVQHY 163
C+ + R F + LV+HY
Sbjct: 343 ---CIGQRR---FHTMDELVEHY 359
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,045,640
Number of Sequences: 37866
Number of extensions: 682472
Number of successful extensions: 8260
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 185
Number of HSP's successfully gapped in prelim test: 192
Number of HSP's that attempted gapping in prelim test: 6170
Number of HSP's gapped (non-prelim): 2002
length of query: 258
length of database: 18,247,518
effective HSP length: 100
effective length of query: 158
effective length of database: 14,460,918
effective search space: 2284825044
effective search space used: 2284825044
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.