Search of human proteins with 21536466

Search of human proteins with 21536466

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo
sapiens]
         (894 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]    1850   0.0  
gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]    1824   0.0  
gi|27597078 TYRO3 protein tyrosine kinase [Homo sapiens]              676   0.0  
gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]     650   0.0  
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo...   243   6e-64
gi|42741655 met proto-oncogene isoform b precursor [Homo sapiens]     234   3e-61
gi|188595716 met proto-oncogene isoform a precursor [Homo sapiens]    234   3e-61
gi|119395738 insulin receptor isoform Short precursor [Homo sapi...   225   2e-58
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]   225   2e-58
gi|153946393 macrophage stimulating 1 receptor precursor [Homo s...   222   1e-57
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]   219   1e-56
gi|29029632 anaplastic lymphoma kinase [Homo sapiens]                 218   2e-56
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...   216   1e-55
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...   216   1e-55
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap...   213   5e-55
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]   213   6e-55
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]   213   6e-55
gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precurs...   213   8e-55
gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precurs...   213   8e-55
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]             212   1e-54
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]               212   1e-54
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]             212   1e-54
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]             212   1e-54
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]             212   1e-54
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur...   211   2e-54
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur...   211   2e-54
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur...   211   2e-54
gi|10862701 ret proto-oncogene isoform c [Homo sapiens]               211   2e-54
gi|10862703 ret proto-oncogene isoform a [Homo sapiens]               211   2e-54
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu...   211   2e-54

>gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]
          Length = 894

 Score = 1850 bits (4793), Expect = 0.0
 Identities = 894/894 (100%), Positives = 894/894 (100%)

Query: 1   MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV 60
           MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV
Sbjct: 1   MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV 60

Query: 61  QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF 120
           QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF
Sbjct: 61  QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF 120

Query: 121 LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL 180
           LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL
Sbjct: 121 LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL 180

Query: 181 ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE 240
           ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE
Sbjct: 181 ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE 240

Query: 241 LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH 300
           LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH
Sbjct: 241 LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH 300

Query: 301 PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL 360
           PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL
Sbjct: 301 PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL 360

Query: 361 QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP 420
           QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP
Sbjct: 361 QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP 420

Query: 421 VPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETR 480
           VPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETR
Sbjct: 421 VPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETR 480

Query: 481 YGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGK 540
           YGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGK
Sbjct: 481 YGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGK 540

Query: 541 TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL 600
           TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL
Sbjct: 541 TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL 600

Query: 601 IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM 660
           IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM
Sbjct: 601 IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM 660

Query: 661 EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES 720
           EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES
Sbjct: 661 EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES 720

Query: 721 LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA 780
           LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA
Sbjct: 721 LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA 780

Query: 781 LMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA 840
           LMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA
Sbjct: 781 LMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA 840

Query: 841 DPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA 894
           DPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
Sbjct: 841 DPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA 894


>gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]
          Length = 885

 Score = 1824 bits (4725), Expect = 0.0
 Identities = 885/894 (98%), Positives = 885/894 (98%), Gaps = 9/894 (1%)

Query: 1   MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV 60
           MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV
Sbjct: 1   MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV 60

Query: 61  QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF 120
           QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF
Sbjct: 61  QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF 120

Query: 121 LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL 180
           LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL
Sbjct: 121 LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL 180

Query: 181 ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE 240
           ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE
Sbjct: 181 ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE 240

Query: 241 LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH 300
           LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH
Sbjct: 241 LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH 300

Query: 301 PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL 360
           PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL
Sbjct: 301 PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL 360

Query: 361 QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP 420
           QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP
Sbjct: 361 QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP 420

Query: 421 VPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETR 480
           VPLEAWRP         VKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETR
Sbjct: 421 VPLEAWRP---------VKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETR 471

Query: 481 YGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGK 540
           YGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGK
Sbjct: 472 YGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGK 531

Query: 541 TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL 600
           TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL
Sbjct: 532 TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL 591

Query: 601 IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM 660
           IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM
Sbjct: 592 IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM 651

Query: 661 EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES 720
           EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES
Sbjct: 652 EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES 711

Query: 721 LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA 780
           LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA
Sbjct: 712 LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA 771

Query: 781 LMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA 840
           LMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA
Sbjct: 772 LMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA 831

Query: 841 DPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA 894
           DPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
Sbjct: 832 DPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA 885


>gi|27597078 TYRO3 protein tyrosine kinase [Homo sapiens]
          Length = 890

 Score =  676 bits (1743), Expect = 0.0
 Identities = 383/884 (43%), Positives = 525/884 (59%), Gaps = 70/884 (7%)

Query: 6   PRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPP 65
           PR+G       L L   A +    + A     +G P  +T ++G    L C ++   E P
Sbjct: 21  PRLG-------LLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGM-EEP 72

Query: 66  EVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQT 125
           ++ W++DG +++  D  Q  +P+ E     WI    L + S++ SD G+Y C V  G +T
Sbjct: 73  DIQWVKDGAVVQNLD--QLYIPVSEQH---WI--GFLSLKSVERSDAGRYWCQVEDGGET 125

Query: 126 FVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPG 185
            +SQP ++ +EG+P+F  EP+D  V  N PF LSC+A GPPEPV ++W +    +    G
Sbjct: 126 EISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIG---G 182

Query: 186 HGPQRS-LHVPGLNKTSSFSCEAHNAKGVTTSRTATITV--LPQQPRNLHLVSRQPTELE 242
             P  S L+V G+ +++ FSCEAHN KG+ +SRTAT+ +  LP  P N+ +     +   
Sbjct: 183 PAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNAS 242

Query: 243 VAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPH 302
           VAW PG  G   L  CT+Q   +  G            E L     VPP    L  L P 
Sbjct: 243 VAWMPGADGRALLQSCTVQVTQAPGGW-----------EVLAVVVPVPPFTCLLRDLVPA 291

Query: 303 TPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQE--PRAPL 360
           T Y +RV C ++ GPS +  W+P +T    P   P+N+ A R  S   + W+E  P APL
Sbjct: 292 TNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPL 351

Query: 361 QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLE-----LQGDGSVSNLTVCVAAYTAAGDG 415
           +G L  Y+L++        + D G + E+T+E     L G     +L V V    A G G
Sbjct: 352 EGPLGPYKLSW--------VQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCG 403

Query: 416 PWSLPVPLEAW-RPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHR 474
           PWS P+ + +  R GQ  P H              W  V+LG + A      LAL L+ +
Sbjct: 404 PWSQPLVVSSHDRAGQQGPPHSRTS----------WVPVVLGVLTALVTAAALALILLRK 453

Query: 475 RKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTE---ATLNSLGISEELKEKLRDVMV 531
           R+KETR+G+ F+  + RGE  V +R  +S++R   E   ATL+SLGIS+ELKEKL DV++
Sbjct: 454 RRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLI 513

Query: 532 DRHKVALGKTLGEGEFGAVMEGQLNQDD-SILKVAVKTMKIAICTRSELEDFLSEAVCMK 590
              +  LG+ LG+GEFG+V E QL Q+D S +KVAVK +K  I   S++E+FL EA CMK
Sbjct: 514 PEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMK 573

Query: 591 EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLV 650
           EFDHP+V +L+GV  +   +   P P+VILPFMKHGDLH+FLL SR+G+ P  LP Q L+
Sbjct: 574 EFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLI 633

Query: 651 KFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAK 710
           +FM DIA GMEYLS++ FIHRDLAARNCML E+M+VCVADFGLS+KIY+GDYYRQG  +K
Sbjct: 634 RFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASK 693

Query: 711 MPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQ 770
           +PVKW+A+ESLAD +YT +SDVW+FGVTMWEI TRGQTPY G+EN+EIY+YL  GNRLKQ
Sbjct: 694 LPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQ 753

Query: 771 PADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGY 830
           P +C++ +Y LM +CW  +P+ RPSFT LR +LEN L  L       + LY+N++     
Sbjct: 754 PPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERA--- 810

Query: 831 PEPPGAAGGADPPTQPDPKDSC---SCLTAAEVHPAG-RYVLCP 870
            E P A G  + P +  P       S + A    P+  RY+L P
Sbjct: 811 -EEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTP 853


>gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]
          Length = 999

 Score =  650 bits (1676), Expect = 0.0
 Identities = 389/919 (42%), Positives = 537/919 (58%), Gaps = 94/919 (10%)

Query: 27  PRGTQAEESP-----FVGNPGNITGARGLTGTLRCQLQVQG--EPPEVHWLRDGQILELA 79
           P+ T  E  P     F    G+I  +        C + V    +   + W +DG+ L  A
Sbjct: 81  PQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGA 140

Query: 80  DSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLP 139
               TQ      + +   +++   ITS+Q SD G Y C + + ++  VS P Y+ ++GLP
Sbjct: 141 HHAITQF---YPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLP 197

Query: 140 YFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNK 199
           +F ++PE   V  NT FNL+CQA GPPEPV++ W+Q++  +   P   P   L VPGL +
Sbjct: 198 HFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPS-VLTVPGLTE 256

Query: 200 TSSFSCEAHNAKGVTTSRTATITV--LPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTH 257
            + FSCEAHN KG+T S+   I +  +P  P  + + +     + ++W PG  G  P  +
Sbjct: 257 MAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRN 316

Query: 258 CTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGP 317
           C++Q         ++  +P      +    S  PH  ++  L     Y I V+C +  G 
Sbjct: 317 CSIQ---------VKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGW 367

Query: 318 SSWTHWLPVETPEGVPLGPPENISATRNGSQ--AFVHWQEPRAPLQ-GTLLGYRLAYQGQ 374
           S+ + W+   T EG P   P N++   N S     + W +P    Q G L+GYR+++  Q
Sbjct: 368 SAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQ 427

Query: 375 D---TPEVLMDIGL---RQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPV----PLE 424
               + E+L ++G    R  +++++      +  TV +AA T  G GP+S PV    P  
Sbjct: 428 SAGISKELLEEVGQNGSRARISVQVHN----ATCTVRIAAVTRGGVGPFSDPVKIFIPAH 483

Query: 425 AW---------RPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFL-VHR 474
            W          PG A PV  +        F     ++L+G        LIL + L + +
Sbjct: 484 GWVDYAPSSTPAPGNADPVLII--------FGCFCGFILIG--------LILYISLAIRK 527

Query: 475 RKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRH 534
           R +ET++G  F  T E  ELVV Y  +KS+ RR  E TL+SLG+SEEL+ KL DV++DR+
Sbjct: 528 RVQETKFGNAF--TEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRN 585

Query: 535 KVALGKTLGEGEFGAVMEGQLNQDDSI-LKVAVKTMKIAICTRSELEDFLSEAVCMKEFD 593
            + LGK LGEGEFG+VMEG L Q+D   LKVAVKTMK+   ++ E+E+FLSEA CMK+F 
Sbjct: 586 LLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFS 645

Query: 594 HPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFM 653
           HPNV+RL+GVC + S  +  P P+VILPFMK+GDLH++LLYSRL   P ++P Q L+KFM
Sbjct: 646 HPNVIRLLGVCIEMSS-QGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFM 704

Query: 654 ADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPV 713
            DIA GMEYLS + F+HRDLAARNCML ++M+VCVADFGLSKKIY+GDYYRQGRIAKMPV
Sbjct: 705 VDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPV 764

Query: 714 KWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPAD 773
           KWIAIESLADRVYTSKSDVW+FGVTMWEIATRG TPYPGV+N E+YDYL  G+RLKQP D
Sbjct: 765 KWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPED 824

Query: 774 CLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVN---MDEGGGY 830
           CLD LY +M  CW  +P DRP+F+ LR  LE  L++LP  +   +++YVN   ++   G 
Sbjct: 825 CLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGL 884

Query: 831 PEPPGAAGGADPPTQPD-------PKDSCSCLTAAEVHPA----GRYVLCP--------S 871
            +    A   D    PD       P+ + S +T AEVH +    GRY+L          +
Sbjct: 885 AQGSTLA-PLDLNIDPDSIIASCTPRAAISVVT-AEVHDSKPHEGRYILNGGSEEWEDLT 942

Query: 872 TTPSPAQPADRGSPAAPGQ 890
           + PS A  A++ S   PG+
Sbjct: 943 SAPSAAVTAEKNS-VLPGE 960


>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
            sapiens]
          Length = 1367

 Score =  243 bits (620), Expect = 6e-64
 Identities = 171/539 (31%), Positives = 270/539 (50%), Gaps = 83/539 (15%)

Query: 296  LGSLHPHTPYHI----------RVACTSSQGPSSWTHWLPVETPEGVPLGP------PEN 339
            + +L P T Y I          ++ C++S    + T  +P E  + +P GP      PEN
Sbjct: 790  ISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFART--MPAEGADDIP-GPVTWEPRPEN 846

Query: 340  ISATRNGSQAFVHWQEPRAPLQGTLLGYRLAY--QGQDTPEVLMDIGLRQEVTLELQGDG 397
                      F+ W EP  P  G +L Y + Y  Q +D  E +     R+    +L    
Sbjct: 847  --------SIFLKWPEPENP-NGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLN 897

Query: 398  SVSNLTVCVAAYTAAGDGPWSLPVPLEAW-RPGQAQPVHQLVKEPSTPAFSWPWWYVLLG 456
               N T  + A + +G+G W+ PV      + G    +H ++  P               
Sbjct: 898  P-GNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPV-------------- 942

Query: 457  AVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSL 516
            AV+     L++ L++ HR++  +R G            V+   V   Y           +
Sbjct: 943  AVLLIVGGLVIMLYVFHRKRNNSRLGNG----------VLYASVNPEYFSAA------DV 986

Query: 517  GISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLN---QDDSILKVAVKTMKIAI 573
             + +E +       V R K+ + + LG+G FG V EG      +D+   +VA+KT+  A 
Sbjct: 987  YVPDEWE-------VAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAA 1039

Query: 574  CTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFL- 632
              R  +E FL+EA  MKEF+  +V+RL+GV  QG         +VI+  M  GDL S+L 
Sbjct: 1040 SMRERIE-FLNEASVMKEFNCHHVVRLLGVVSQGQPT------LVIMELMTRGDLKSYLR 1092

Query: 633  -LYSRLGDQPVYLPTQM--LVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVA 689
             L   + + PV  P  +  +++   +IA GM YL+  +F+HRDLAARNCM+ E+ +V + 
Sbjct: 1093 SLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIG 1152

Query: 690  DFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTP 749
            DFG+++ IY  DYYR+G    +PV+W++ ESL D V+T+ SDVWSFGV +WEIAT  + P
Sbjct: 1153 DFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQP 1212

Query: 750  YPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLK 808
            Y G+ N ++  ++ +G  L +P +C D L+ LM  CW+ NP+ RPSF E+   ++  ++
Sbjct: 1213 YQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEME 1271


>gi|42741655 met proto-oncogene isoform b precursor [Homo sapiens]
          Length = 1390

 Score =  234 bits (597), Expect = 3e-61
 Identities = 126/288 (43%), Positives = 182/288 (63%), Gaps = 18/288 (6%)

Query: 518  ISEELKEKLRDVMVDRHK--VALGKTLGEGEFGAVMEGQL-NQDDSILKVAVKTMKIAIC 574
            ++ EL + ++ V++      V   + +G G FG V  G L + D   +  AVK++   I 
Sbjct: 1058 LNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN-RIT 1116

Query: 575  TRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLY 634
               E+  FL+E + MK+F HPNV+ L+G+C +     S  +P+V+LP+MKHGDL +F+  
Sbjct: 1117 DIGEVSQFLTEGIIMKDFSHPNVLSLLGICLR-----SEGSPLVVLPYMKHGDLRNFIR- 1170

Query: 635  SRLGDQPVYLPT-QMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGL 693
                    + PT + L+ F   +A GM+YL++K+F+HRDLAARNCML+E  +V VADFGL
Sbjct: 1171 -----NETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGL 1225

Query: 694  SKKIYNGDYY--RQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYP 751
            ++ +Y+ +YY       AK+PVKW+A+ESL  + +T+KSDVWSFGV +WE+ TRG  PYP
Sbjct: 1226 ARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYP 1285

Query: 752  GVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTEL 799
             V   +I  YL QG RL QP  C D LY +M +CW    + RPSF+EL
Sbjct: 1286 DVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSEL 1333


>gi|188595716 met proto-oncogene isoform a precursor [Homo sapiens]
          Length = 1408

 Score =  234 bits (597), Expect = 3e-61
 Identities = 126/288 (43%), Positives = 182/288 (63%), Gaps = 18/288 (6%)

Query: 518  ISEELKEKLRDVMVDRHK--VALGKTLGEGEFGAVMEGQL-NQDDSILKVAVKTMKIAIC 574
            ++ EL + ++ V++      V   + +G G FG V  G L + D   +  AVK++   I 
Sbjct: 1076 LNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN-RIT 1134

Query: 575  TRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLY 634
               E+  FL+E + MK+F HPNV+ L+G+C +     S  +P+V+LP+MKHGDL +F+  
Sbjct: 1135 DIGEVSQFLTEGIIMKDFSHPNVLSLLGICLR-----SEGSPLVVLPYMKHGDLRNFIR- 1188

Query: 635  SRLGDQPVYLPT-QMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGL 693
                    + PT + L+ F   +A GM+YL++K+F+HRDLAARNCML+E  +V VADFGL
Sbjct: 1189 -----NETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGL 1243

Query: 694  SKKIYNGDYY--RQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYP 751
            ++ +Y+ +YY       AK+PVKW+A+ESL  + +T+KSDVWSFGV +WE+ TRG  PYP
Sbjct: 1244 ARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYP 1303

Query: 752  GVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTEL 799
             V   +I  YL QG RL QP  C D LY +M +CW    + RPSF+EL
Sbjct: 1304 DVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSEL 1351


>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
          Length = 1370

 Score =  225 bits (573), Expect = 2e-58
 Identities = 169/550 (30%), Positives = 265/550 (48%), Gaps = 62/550 (11%)

Query: 276  PDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLG 335
            P  PEE    +  V    L +  L   T Y I +   +   P          +   +P  
Sbjct: 777  PTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEA 836

Query: 336  PPENISATRN-----GSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVT 390
              ++I           +   + WQEP+ P  G ++ Y ++Y+     E+ + +  R+   
Sbjct: 837  KADDIVGPVTHEIFENNVVHLMWQEPKEP-NGLIVLYEVSYRRYGDEELHLCVS-RKHFA 894

Query: 391  LE----LQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPA- 445
            LE    L+G  S  N +V + A + AG+G W+ P             V   +  PS  A 
Sbjct: 895  LERGCRLRGL-SPGNYSVRIRATSLAGNGSWTEPTYFY---------VTDYLDVPSNIAK 944

Query: 446  -FSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSY 504
                P  +V L +VV  +  L L       RK++             G L   Y      
Sbjct: 945  IIIGPLIFVFLFSVVIGSIYLFL-------RKRQPD-----------GPLGPLYASSNPE 986

Query: 505  SRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLN---QDDSI 561
                ++    S+ + +E +       V R K+ L + LG+G FG V EG      + ++ 
Sbjct: 987  YLSASDVFPCSVYVPDEWE-------VSREKITLLRELGQGSFGMVYEGNARDIIKGEAE 1039

Query: 562  LKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILP 621
             +VAVKT+  +   R  +E FL+EA  MK F   +V+RL+GV  +G         +V++ 
Sbjct: 1040 TRVAVKTVNESASLRERIE-FLNEASVMKGFTCHHVVRLLGVVSKGQPT------LVVME 1092

Query: 622  FMKHGDLHSFL--LYSRLGDQPVYLPT--QMLVKFMADIASGMEYLSTKRFIHRDLAARN 677
             M HGDL S+L  L     + P   P   Q +++  A+IA GM YL+ K+F+HRDLAARN
Sbjct: 1093 LMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARN 1152

Query: 678  CMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGV 737
            CM+  + +V + DFG+++ IY  DYYR+G    +PV+W+A ESL D V+T+ SD+WSFGV
Sbjct: 1153 CMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGV 1212

Query: 738  TMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFT 797
             +WEI +  + PY G+ N ++  ++  G  L QP +C + +  LM  CW+ NP+ RP+F 
Sbjct: 1213 VLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFL 1272

Query: 798  ELREDLENTL 807
            E+   L++ L
Sbjct: 1273 EIVNLLKDDL 1282


>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
          Length = 1382

 Score =  225 bits (573), Expect = 2e-58
 Identities = 169/550 (30%), Positives = 265/550 (48%), Gaps = 62/550 (11%)

Query: 276  PDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLG 335
            P  PEE    +  V    L +  L   T Y I +   +   P          +   +P  
Sbjct: 789  PTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEA 848

Query: 336  PPENISATRN-----GSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVT 390
              ++I           +   + WQEP+ P  G ++ Y ++Y+     E+ + +  R+   
Sbjct: 849  KADDIVGPVTHEIFENNVVHLMWQEPKEP-NGLIVLYEVSYRRYGDEELHLCVS-RKHFA 906

Query: 391  LE----LQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPA- 445
            LE    L+G  S  N +V + A + AG+G W+ P             V   +  PS  A 
Sbjct: 907  LERGCRLRGL-SPGNYSVRIRATSLAGNGSWTEPTYFY---------VTDYLDVPSNIAK 956

Query: 446  -FSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSY 504
                P  +V L +VV  +  L L       RK++             G L   Y      
Sbjct: 957  IIIGPLIFVFLFSVVIGSIYLFL-------RKRQPD-----------GPLGPLYASSNPE 998

Query: 505  SRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLN---QDDSI 561
                ++    S+ + +E +       V R K+ L + LG+G FG V EG      + ++ 
Sbjct: 999  YLSASDVFPCSVYVPDEWE-------VSREKITLLRELGQGSFGMVYEGNARDIIKGEAE 1051

Query: 562  LKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILP 621
             +VAVKT+  +   R  +E FL+EA  MK F   +V+RL+GV  +G         +V++ 
Sbjct: 1052 TRVAVKTVNESASLRERIE-FLNEASVMKGFTCHHVVRLLGVVSKGQPT------LVVME 1104

Query: 622  FMKHGDLHSFL--LYSRLGDQPVYLPT--QMLVKFMADIASGMEYLSTKRFIHRDLAARN 677
             M HGDL S+L  L     + P   P   Q +++  A+IA GM YL+ K+F+HRDLAARN
Sbjct: 1105 LMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARN 1164

Query: 678  CMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGV 737
            CM+  + +V + DFG+++ IY  DYYR+G    +PV+W+A ESL D V+T+ SD+WSFGV
Sbjct: 1165 CMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGV 1224

Query: 738  TMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFT 797
             +WEI +  + PY G+ N ++  ++  G  L QP +C + +  LM  CW+ NP+ RP+F 
Sbjct: 1225 VLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFL 1284

Query: 798  ELREDLENTL 807
            E+   L++ L
Sbjct: 1285 EIVNLLKDDL 1294


>gi|153946393 macrophage stimulating 1 receptor precursor [Homo
            sapiens]
          Length = 1400

 Score =  222 bits (566), Expect = 1e-57
 Identities = 121/299 (40%), Positives = 185/299 (61%), Gaps = 18/299 (6%)

Query: 518  ISEELKEKLRDVMVDRHKVAL--GKTLGEGEFGAVMEGQ-LNQDDSILKVAVKTMKIAIC 574
            +   L  +++DV++   +V     + +G+G FG V  G+ ++Q  + ++ A+K++   I 
Sbjct: 1062 LDSALLAEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLS-RIT 1120

Query: 575  TRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLY 634
               ++E FL E + M+  +HPNV+ LIG+            P V+LP+M HGDL  F+  
Sbjct: 1121 EMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEG-----LPHVLLPYMCHGDLLQFIR- 1174

Query: 635  SRLGDQPVYLPT-QMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGL 693
                  P   PT + L+ F   +A GMEYL+ ++F+HRDLAARNCML+E+ +V VADFGL
Sbjct: 1175 -----SPQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGL 1229

Query: 694  SKKIYNGDYY--RQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYP 751
            ++ I + +YY  +Q R A++PVKW+A+ESL    +T+KSDVWSFGV +WE+ TRG  PY 
Sbjct: 1230 ARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYR 1289

Query: 752  GVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKAL 810
             ++  ++  +L QG RL QP  C D LY +M +CWE +P  RP+F  L  ++E  + AL
Sbjct: 1290 HIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSAL 1348


>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
          Length = 2347

 Score =  219 bits (557), Expect = 1e-56
 Identities = 167/546 (30%), Positives = 263/546 (48%), Gaps = 58/546 (10%)

Query: 284  TSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISAT 343
            TS +  P +   + +L P+T Y++RV      G +S +     +T  GVP  P   I   
Sbjct: 1704 TSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENSTSLPESFKTKAGVPNKP--GIPKL 1761

Query: 344  RNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLT 403
              GS+  + W+  +A   G  + Y +    + T   L +  LR ++T     +GS S++ 
Sbjct: 1762 LEGSKNSIQWE--KAEDNGCRITYYILEIRKSTSNNLQNQNLRWKMTF----NGSCSSVC 1815

Query: 404  VC------------VAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPWW 451
                          V A    G G +S          G ++ +  +  +   P  S+   
Sbjct: 1816 TWKSKNLKGIFQFRVVAANNLGFGEYS----------GISENIILVGDDFWIPETSF--- 1862

Query: 452  YVLLGAVVAAACVLILAL-FLVHRRKKETRYGEVFEPTV--ERGELVVRYRVRKSYSRRT 508
              +L  +V    V+ + L F+ HRR K  +  +     +  E  EL     +        
Sbjct: 1863 --ILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLAN 1920

Query: 509  TEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQ----LNQDDSILKV 564
                +++L   EE++         R K+ L   LG G FG V EG     L      +KV
Sbjct: 1921 ACYAIHTLPTQEEIENL---PAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKV 1977

Query: 565  AVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMK 624
            AVKT+K     + ++E FL EA  M +F+HPN+++ +GVC     +       +IL  M+
Sbjct: 1978 AVKTLKKGSTDQEKIE-FLKEAHLMSKFNHPNILKQLGVCLLNEPQ------YIILELME 2030

Query: 625  HGDLHSFLLYSRLGDQPVYLPTQM-LVKFMADIASGMEYLSTKRFIHRDLAARNCMLNEN 683
             GDL ++L  +R+      L T + LV    DI+ G  YL    FIHRDLAARNC+++  
Sbjct: 2031 GGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVK 2090

Query: 684  -----MSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVT 738
                   V + DFGL++ IY  DYYR+     +PV+W+A ESL D ++T++SDVWSFG+ 
Sbjct: 2091 DYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGIL 2150

Query: 739  MWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTE 798
            +WEI T G  PYP   N ++ +Y++ G RL+ P +C D L+ LM++CW   P  RP+F  
Sbjct: 2151 IWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHR 2210

Query: 799  LREDLE 804
            +++ L+
Sbjct: 2211 IQDQLQ 2216



 Score = 32.0 bits (71), Expect = 2.6
 Identities = 38/147 (25%), Positives = 48/147 (32%), Gaps = 34/147 (23%)

Query: 316 GPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLL---------- 365
           G SS  H LP         G P+ +S      QA V W+ P   +   ++          
Sbjct: 549 GSSSQLHPLP---------GRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFE 599

Query: 366 ---------GYRLAYQGQDTPEV---LMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAG 413
                     Y +    QD PEV    ++I        ELQ   S     V V A +   
Sbjct: 600 LGPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQ---SAMKYKVSVRASSPKR 656

Query: 414 DGPWSLPVPLEAWRPGQAQPVHQLVKE 440
            GPWS P       P    P    VKE
Sbjct: 657 PGPWSEPSVGTTLVPASEPPFIMAVKE 683


>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
          Length = 1620

 Score =  218 bits (555), Expect = 2e-56
 Identities = 134/382 (35%), Positives = 203/382 (53%), Gaps = 42/382 (10%)

Query: 453  VLLGAVVAAACVLILALFLVHRRKKETRYG---EVFEPTVERGEL-----VVRYRVRKSY 504
            V+  A+VAA  +    + +V+RRK +       E+  P  +  +L     +  Y     +
Sbjct: 1039 VVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCF 1098

Query: 505  SRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLN---QDDSI 561
            + +T+  +        +LKE      V R  + L + LG G FG V EGQ++    D S 
Sbjct: 1099 AGKTSSIS--------DLKE------VPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSP 1144

Query: 562  LKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILP 621
            L+VAVKT+   +C+  +  DFL EA+ + +F+H N++R IGV  Q   R       ++L 
Sbjct: 1145 LQVAVKTLP-EVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPR------FILLE 1197

Query: 622  FMKHGDLHSFLLYSR-LGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCML 680
             M  GDL SFL  +R    QP  L    L+    DIA G +YL    FIHRD+AARNC+L
Sbjct: 1198 LMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLL 1257

Query: 681  N---ENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGV 737
                      + DFG+++ IY   YYR+G  A +PVKW+  E+  + ++TSK+D WSFGV
Sbjct: 1258 TCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGV 1317

Query: 738  TMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFT 797
             +WEI + G  PYP   N E+ +++  G R+  P +C   +Y +M++CW+  P+DRP+F 
Sbjct: 1318 LLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFA 1377

Query: 798  ELREDLENTLKALPPAQEPDEI 819
             + E +E         Q+PD I
Sbjct: 1378 IILERIEYC------TQDPDVI 1393


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score =  216 bits (549), Expect = 1e-55
 Identities = 122/290 (42%), Positives = 173/290 (59%), Gaps = 16/290 (5%)

Query: 531 VDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMK 590
           ++R  + +   LG G++G V EG   +    L VAVKT+K       E+E+FL EA  MK
Sbjct: 237 MERTDITMKHKLGGGQYGEVYEGVWKKYS--LTVAVKTLKE---DTMEVEEFLKEAAVMK 291

Query: 591 EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLV 650
           E  HPN+++L+GVC     RE  P   +I  FM +G+L  +L      +    +   +L+
Sbjct: 292 EIKHPNLVQLLGVC----TRE--PPFYIITEFMTYGNLLDYLRECNRQE----VNAVVLL 341

Query: 651 KFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAK 710
                I+S MEYL  K FIHRDLAARNC++ EN  V VADFGLS+ +  GD Y     AK
Sbjct: 342 YMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR-LMTGDTYTAHAGAK 400

Query: 711 MPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQ 770
            P+KW A ESLA   ++ KSDVW+FGV +WEIAT G +PYPG++ S++Y+ L +  R+++
Sbjct: 401 FPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMER 460

Query: 771 PADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEIL 820
           P  C + +Y LM  CW+ NP DRPSF E+ +  E   +    + E ++ L
Sbjct: 461 PEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKEL 510


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score =  216 bits (549), Expect = 1e-55
 Identities = 122/290 (42%), Positives = 173/290 (59%), Gaps = 16/290 (5%)

Query: 531 VDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMK 590
           ++R  + +   LG G++G V EG   +    L VAVKT+K       E+E+FL EA  MK
Sbjct: 256 MERTDITMKHKLGGGQYGEVYEGVWKKYS--LTVAVKTLKE---DTMEVEEFLKEAAVMK 310

Query: 591 EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLV 650
           E  HPN+++L+GVC     RE  P   +I  FM +G+L  +L      +    +   +L+
Sbjct: 311 EIKHPNLVQLLGVC----TRE--PPFYIITEFMTYGNLLDYLRECNRQE----VNAVVLL 360

Query: 651 KFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAK 710
                I+S MEYL  K FIHRDLAARNC++ EN  V VADFGLS+ +  GD Y     AK
Sbjct: 361 YMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR-LMTGDTYTAHAGAK 419

Query: 711 MPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQ 770
            P+KW A ESLA   ++ KSDVW+FGV +WEIAT G +PYPG++ S++Y+ L +  R+++
Sbjct: 420 FPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMER 479

Query: 771 PADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEIL 820
           P  C + +Y LM  CW+ NP DRPSF E+ +  E   +    + E ++ L
Sbjct: 480 PEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKEL 529


>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
          Length = 1124

 Score =  213 bits (543), Expect = 5e-55
 Identities = 178/615 (28%), Positives = 288/615 (46%), Gaps = 79/615 (12%)

Query: 218  TATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPD 277
            TA+I + P  PR L+L+ +  T L + W P    I+P          S+D   ++  E  
Sbjct: 538  TASIGLPP--PRGLNLLPKSQTTLNLTWQP----IFPS---------SEDDFYVEV-ERR 581

Query: 278  PPEEPLTSQASVPPH--QLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLG 335
              ++       VP +   + L +LHP   Y +R A  +++    W+  L   T   +   
Sbjct: 582  SVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVR-ARVNTKAQGEWSEDLTAWTLSDILPP 640

Query: 336  PPENISATR-NGSQAFVHWQEPRA-PLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLEL 393
             PENI  +    S A + W       +    + Y++  + +D     +D+ ++     + 
Sbjct: 641  QPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQH---VDVKIKNATITQY 697

Query: 394  QGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPV--HQLVKEPSTPA-FSWPW 450
            Q  G        V  +     G               + P   H+LV  P + A      
Sbjct: 698  QLKGLEPETAYQVDIFAENNIG--------------SSNPAFSHELVTLPESQAPADLGG 743

Query: 451  WYVLLGAVVAAA---CVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRR 507
              +LL A++ +A   C+ +L  FL+  + K           V+R        VR+  + +
Sbjct: 744  GKMLLIAILGSAGMTCLTVLLAFLIILQLKRAN--------VQRRMAQAFQNVREEPAVQ 795

Query: 508  TTEATLNSLGISEELKEKLRDVM---VDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKV 564
                TL    ++ ++K      +   +D + +     +GEG FG V++ ++ +D   +  
Sbjct: 796  FNSGTL---ALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDA 852

Query: 565  AVKTMKIAICTRSELEDFLSEA-VCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFM 623
            A+K MK    ++ +  DF  E  V  K   HPN++ L+G C      E      + + + 
Sbjct: 853  AIKRMK-EYASKDDHRDFAGELEVLCKLGHHPNIINLLGAC------EHRGYLYLAIEYA 905

Query: 624  KHGDLHSFLLYSR-LGDQPVY---------LPTQMLVKFMADIASGMEYLSTKRFIHRDL 673
             HG+L  FL  SR L   P +         L +Q L+ F AD+A GM+YLS K+FIHRDL
Sbjct: 906  PHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDL 965

Query: 674  AARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVW 733
            AARN ++ EN    +ADFGLS+     + Y +  + ++PV+W+AIESL   VYT+ SDVW
Sbjct: 966  AARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVW 1022

Query: 734  SFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDR 793
            S+GV +WEI + G TPY G+  +E+Y+ L QG RL++P +C D +Y LM +CW   P +R
Sbjct: 1023 SYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYER 1082

Query: 794  PSFTELREDLENTLK 808
            PSF ++   L   L+
Sbjct: 1083 PSFAQILVSLNRMLE 1097


>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
          Length = 1074

 Score =  213 bits (542), Expect = 6e-55
 Identities = 123/334 (36%), Positives = 188/334 (56%), Gaps = 29/334 (8%)

Query: 527 RDVMVDRHKVALGKTLGEGEFGAVMEG-QLNQDDSILKVAVKTMKIAICTRSEL-EDFLS 584
           RD  + R ++ LG+ +GEG+FG V +G  ++ ++  L VA+KT K   CT   + E FL 
Sbjct: 435 RDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKN--CTSDSVREKFLQ 492

Query: 585 EAVCMKEFDHPNVMRLIGVCFQGSERESFPAPV-VILPFMKHGDLHSFLLYSRLGDQPVY 643
           EA+ M++FDHP++++LIGV  +         PV +I+     G+L SFL   +       
Sbjct: 493 EALTMRQFDHPHIVKLIGVITEN--------PVWIIMELCTLGELRSFLQVRKYS----- 539

Query: 644 LPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYY 703
           L    L+ +   +++ + YL +KRF+HRD+AARN +++ N  V + DFGLS+ + +  YY
Sbjct: 540 LDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYY 599

Query: 704 RQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLR 763
           +  +  K+P+KW+A ES+  R +TS SDVW FGV MWEI   G  P+ GV+N+++   + 
Sbjct: 600 KASK-GKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIE 658

Query: 764 QGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEIL--- 820
            G RL  P +C   LY+LM++CW  +P  RP FTEL+  L   L+     QE    +   
Sbjct: 659 NGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESR 718

Query: 821 ---YVNMDEGGGYPEPPGAAGGADPPTQPDPKDS 851
               V+ D GG    PP  +     P  P P+ S
Sbjct: 719 RQATVSWDSGGSDEAPPKPS----RPGYPSPRSS 748


>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
          Length = 1052

 Score =  213 bits (542), Expect = 6e-55
 Identities = 123/334 (36%), Positives = 188/334 (56%), Gaps = 29/334 (8%)

Query: 527 RDVMVDRHKVALGKTLGEGEFGAVMEG-QLNQDDSILKVAVKTMKIAICTRSEL-EDFLS 584
           RD  + R ++ LG+ +GEG+FG V +G  ++ ++  L VA+KT K   CT   + E FL 
Sbjct: 413 RDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKN--CTSDSVREKFLQ 470

Query: 585 EAVCMKEFDHPNVMRLIGVCFQGSERESFPAPV-VILPFMKHGDLHSFLLYSRLGDQPVY 643
           EA+ M++FDHP++++LIGV  +         PV +I+     G+L SFL   +       
Sbjct: 471 EALTMRQFDHPHIVKLIGVITEN--------PVWIIMELCTLGELRSFLQVRKYS----- 517

Query: 644 LPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYY 703
           L    L+ +   +++ + YL +KRF+HRD+AARN +++ N  V + DFGLS+ + +  YY
Sbjct: 518 LDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYY 577

Query: 704 RQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLR 763
           +  +  K+P+KW+A ES+  R +TS SDVW FGV MWEI   G  P+ GV+N+++   + 
Sbjct: 578 KASK-GKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIE 636

Query: 764 QGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEIL--- 820
            G RL  P +C   LY+LM++CW  +P  RP FTEL+  L   L+     QE    +   
Sbjct: 637 NGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESR 696

Query: 821 ---YVNMDEGGGYPEPPGAAGGADPPTQPDPKDS 851
               V+ D GG    PP  +     P  P P+ S
Sbjct: 697 RQATVSWDSGGSDEAPPKPS----RPGYPSPRSS 726


>gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precursor
           [Homo sapiens]
          Length = 864

 Score =  213 bits (541), Expect = 8e-55
 Identities = 139/396 (35%), Positives = 213/396 (53%), Gaps = 25/396 (6%)

Query: 453 VLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEAT 512
           VL+ AVVA + + +L +  V    K+ ++  + E  +   EL +  ++R S  R      
Sbjct: 426 VLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELS-KLRTSAIRTAPNPY 484

Query: 513 LNSLGISEELKEKLRDVM--VDRHKVALGKTLGEGEFGAVMEGQ---LNQDDSILKVAVK 567
              +G+       L   +  V    V L + LG G FG V EG    L  D S L+VA+K
Sbjct: 485 YCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIK 544

Query: 568 TMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGD 627
           T+   +C+  +  DFL EA+ + +F H N++R +G+  + + R      +++L  M  GD
Sbjct: 545 TLP-ELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPR------LILLELMSGGD 597

Query: 628 LHSFLLYSR--LGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLN---E 682
           + SFL +SR  LG QP  L  + L++   DIA G  YL    FIHRD+AARNC+L+    
Sbjct: 598 MKSFLRHSRPHLG-QPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGP 656

Query: 683 NMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEI 742
           +    + DFG+++ IY   YYR+G  A +PVKW+  E+  + ++TSK+D WSFGV +WEI
Sbjct: 657 SRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEI 716

Query: 743 ATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELRED 802
            + G  PYPG  N E+ D++  G R+  P  C   +Y +M++CW+  P+ RPSF  + E 
Sbjct: 717 FSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILER 776

Query: 803 LENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAG 838
           L+         Q+PD +  +   E G  PE  G +G
Sbjct: 777 LQYC------TQDPDVLNSLLPMELGPTPEEEGTSG 806


>gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precursor
           [Homo sapiens]
          Length = 803

 Score =  213 bits (541), Expect = 8e-55
 Identities = 139/396 (35%), Positives = 213/396 (53%), Gaps = 25/396 (6%)

Query: 453 VLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEAT 512
           VL+ AVVA + + +L +  V    K+ ++  + E  +   EL +  ++R S  R      
Sbjct: 365 VLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELS-KLRTSAIRTAPNPY 423

Query: 513 LNSLGISEELKEKLRDVM--VDRHKVALGKTLGEGEFGAVMEGQ---LNQDDSILKVAVK 567
              +G+       L   +  V    V L + LG G FG V EG    L  D S L+VA+K
Sbjct: 424 YCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIK 483

Query: 568 TMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGD 627
           T+   +C+  +  DFL EA+ + +F H N++R +G+  + + R      +++L  M  GD
Sbjct: 484 TLP-ELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPR------LILLELMSGGD 536

Query: 628 LHSFLLYSR--LGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLN---E 682
           + SFL +SR  LG QP  L  + L++   DIA G  YL    FIHRD+AARNC+L+    
Sbjct: 537 MKSFLRHSRPHLG-QPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGP 595

Query: 683 NMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEI 742
           +    + DFG+++ IY   YYR+G  A +PVKW+  E+  + ++TSK+D WSFGV +WEI
Sbjct: 596 SRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEI 655

Query: 743 ATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELRED 802
            + G  PYPG  N E+ D++  G R+  P  C   +Y +M++CW+  P+ RPSF  + E 
Sbjct: 656 FSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILER 715

Query: 803 LENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAG 838
           L+         Q+PD +  +   E G  PE  G +G
Sbjct: 716 LQYC------TQDPDVLNSLLPMELGPTPEEEGTSG 745


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score =  212 bits (539), Expect = 1e-54
 Identities = 119/275 (43%), Positives = 166/275 (60%), Gaps = 18/275 (6%)

Query: 531 VDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMK 590
           ++R  + +   LG G++G V  G   +    L VAVKT+K       E+E+FL EA  MK
Sbjct: 268 MERTDITMKHKLGGGQYGEVYVGVWKKYS--LTVAVKTLKE---DTMEVEEFLKEAAVMK 322

Query: 591 EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLV 650
           E  HPN+++L+GVC         P   ++  +M +G+L  +L      +      T +++
Sbjct: 323 EIKHPNLVQLLGVCTLE------PPFYIVTEYMPYGNLLDYLRECNREEV-----TAVVL 371

Query: 651 KFMA-DIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIA 709
            +MA  I+S MEYL  K FIHRDLAARNC++ EN  V VADFGLS+ +  GD Y     A
Sbjct: 372 LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGA 430

Query: 710 KMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLK 769
           K P+KW A ESLA   ++ KSDVW+FGV +WEIAT G +PYPG++ S++YD L +G R++
Sbjct: 431 KFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRME 490

Query: 770 QPADCLDGLYALMSRCWELNPQDRPSFTELREDLE 804
           QP  C   +Y LM  CW+ +P DRPSF E  +  E
Sbjct: 491 QPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE 525


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score =  212 bits (539), Expect = 1e-54
 Identities = 119/275 (43%), Positives = 166/275 (60%), Gaps = 18/275 (6%)

Query: 531 VDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMK 590
           ++R  + +   LG G++G V  G   +    L VAVKT+K       E+E+FL EA  MK
Sbjct: 283 MERTDITMKHKLGGGQYGEVYVGVWKKYS--LTVAVKTLKE---DTMEVEEFLKEAAVMK 337

Query: 591 EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLV 650
           E  HPN+++L+GVC         P   ++  +M +G+L  +L      +      T +++
Sbjct: 338 EIKHPNLVQLLGVCTLE------PPFYIVTEYMPYGNLLDYLRECNREEV-----TAVVL 386

Query: 651 KFMA-DIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIA 709
            +MA  I+S MEYL  K FIHRDLAARNC++ EN  V VADFGLS+ +  GD Y     A
Sbjct: 387 LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGA 445

Query: 710 KMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLK 769
           K P+KW A ESLA   ++ KSDVW+FGV +WEIAT G +PYPG++ S++YD L +G R++
Sbjct: 446 KFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRME 505

Query: 770 QPADCLDGLYALMSRCWELNPQDRPSFTELREDLE 804
           QP  C   +Y LM  CW+ +P DRPSF E  +  E
Sbjct: 506 QPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE 540


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score =  212 bits (539), Expect = 1e-54
 Identities = 119/275 (43%), Positives = 166/275 (60%), Gaps = 18/275 (6%)

Query: 531 VDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMK 590
           ++R  + +   LG G++G V  G   +    L VAVKT+K       E+E+FL EA  MK
Sbjct: 262 MERTDITMKHKLGGGQYGEVYVGVWKKYS--LTVAVKTLKE---DTMEVEEFLKEAAVMK 316

Query: 591 EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLV 650
           E  HPN+++L+GVC         P   ++  +M +G+L  +L      +      T +++
Sbjct: 317 EIKHPNLVQLLGVCTLE------PPFYIVTEYMPYGNLLDYLRECNREEV-----TAVVL 365

Query: 651 KFMA-DIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIA 709
            +MA  I+S MEYL  K FIHRDLAARNC++ EN  V VADFGLS+ +  GD Y     A
Sbjct: 366 LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGA 424

Query: 710 KMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLK 769
           K P+KW A ESLA   ++ KSDVW+FGV +WEIAT G +PYPG++ S++YD L +G R++
Sbjct: 425 KFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRME 484

Query: 770 QPADCLDGLYALMSRCWELNPQDRPSFTELREDLE 804
           QP  C   +Y LM  CW+ +P DRPSF E  +  E
Sbjct: 485 QPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE 519


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score =  212 bits (539), Expect = 1e-54
 Identities = 119/275 (43%), Positives = 166/275 (60%), Gaps = 18/275 (6%)

Query: 531 VDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMK 590
           ++R  + +   LG G++G V  G   +    L VAVKT+K       E+E+FL EA  MK
Sbjct: 268 MERTDITMKHKLGGGQYGEVYVGVWKKYS--LTVAVKTLKE---DTMEVEEFLKEAAVMK 322

Query: 591 EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLV 650
           E  HPN+++L+GVC         P   ++  +M +G+L  +L      +      T +++
Sbjct: 323 EIKHPNLVQLLGVCTLE------PPFYIVTEYMPYGNLLDYLRECNREEV-----TAVVL 371

Query: 651 KFMA-DIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIA 709
            +MA  I+S MEYL  K FIHRDLAARNC++ EN  V VADFGLS+ +  GD Y     A
Sbjct: 372 LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGA 430

Query: 710 KMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLK 769
           K P+KW A ESLA   ++ KSDVW+FGV +WEIAT G +PYPG++ S++YD L +G R++
Sbjct: 431 KFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRME 490

Query: 770 QPADCLDGLYALMSRCWELNPQDRPSFTELREDLE 804
           QP  C   +Y LM  CW+ +P DRPSF E  +  E
Sbjct: 491 QPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE 525


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score =  212 bits (539), Expect = 1e-54
 Identities = 119/275 (43%), Positives = 166/275 (60%), Gaps = 18/275 (6%)

Query: 531 VDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMK 590
           ++R  + +   LG G++G V  G   +    L VAVKT+K       E+E+FL EA  MK
Sbjct: 247 MERTDITMKHKLGGGQYGEVYVGVWKKYS--LTVAVKTLKE---DTMEVEEFLKEAAVMK 301

Query: 591 EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLV 650
           E  HPN+++L+GVC         P   ++  +M +G+L  +L      +      T +++
Sbjct: 302 EIKHPNLVQLLGVCTLE------PPFYIVTEYMPYGNLLDYLRECNREEV-----TAVVL 350

Query: 651 KFMA-DIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIA 709
            +MA  I+S MEYL  K FIHRDLAARNC++ EN  V VADFGLS+ +  GD Y     A
Sbjct: 351 LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGA 409

Query: 710 KMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLK 769
           K P+KW A ESLA   ++ KSDVW+FGV +WEIAT G +PYPG++ S++YD L +G R++
Sbjct: 410 KFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRME 469

Query: 770 QPADCLDGLYALMSRCWELNPQDRPSFTELREDLE 804
           QP  C   +Y LM  CW+ +P DRPSF E  +  E
Sbjct: 470 QPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE 504


>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
           [Homo sapiens]
          Length = 731

 Score =  211 bits (538), Expect = 2e-54
 Identities = 138/378 (36%), Positives = 210/378 (55%), Gaps = 31/378 (8%)

Query: 505 SRRTTEATLNSLGISE-ELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQ---LNQD-- 558
           SR ++  T    G+SE EL E  R  +  R ++ LGK LGEG FG V+  +   L++D  
Sbjct: 356 SRLSSSGTPMLAGVSEYELPEDPRWEL-PRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKP 414

Query: 559 DSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFD-HPNVMRLIGVCFQGSERESFPAPV 617
           + + KVAVK +K +  T  +L D +SE   MK    H N++ L+G C Q           
Sbjct: 415 NRVTKVAVKMLK-SDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPL------Y 467

Query: 618 VILPFMKHGDLHSFL----------LYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKR 667
           VI+ +   G+L  +L           Y+   +    L ++ LV     +A GMEYL++K+
Sbjct: 468 VIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKK 527

Query: 668 FIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYT 727
            IHRDLAARN ++ E+  + +ADFGL++ I++ DYY++    ++PVKW+A E+L DR+YT
Sbjct: 528 CIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYT 587

Query: 728 SKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWE 787
            +SDVWSFGV +WEI T G +PYPGV   E++  L++G+R+ +P++C + LY +M  CW 
Sbjct: 588 HQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH 647

Query: 788 LNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGA--AGGADPPTQ 845
             P  RP+F +L EDL+  + AL   QE  ++          +P+   +  + G D    
Sbjct: 648 AVPSQRPTFKQLVEDLDR-IVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFS 706

Query: 846 PDPKDSCSCLTAAEVHPA 863
            +P     CL     HPA
Sbjct: 707 HEPLPEEPCLPR---HPA 721


>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
           [Homo sapiens]
          Length = 733

 Score =  211 bits (538), Expect = 2e-54
 Identities = 138/378 (36%), Positives = 210/378 (55%), Gaps = 31/378 (8%)

Query: 505 SRRTTEATLNSLGISE-ELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQ---LNQD-- 558
           SR ++  T    G+SE EL E  R  +  R ++ LGK LGEG FG V+  +   L++D  
Sbjct: 358 SRLSSSGTPMLAGVSEYELPEDPRWEL-PRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKP 416

Query: 559 DSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFD-HPNVMRLIGVCFQGSERESFPAPV 617
           + + KVAVK +K +  T  +L D +SE   MK    H N++ L+G C Q           
Sbjct: 417 NRVTKVAVKMLK-SDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPL------Y 469

Query: 618 VILPFMKHGDLHSFL----------LYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKR 667
           VI+ +   G+L  +L           Y+   +    L ++ LV     +A GMEYL++K+
Sbjct: 470 VIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKK 529

Query: 668 FIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYT 727
            IHRDLAARN ++ E+  + +ADFGL++ I++ DYY++    ++PVKW+A E+L DR+YT
Sbjct: 530 CIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYT 589

Query: 728 SKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWE 787
            +SDVWSFGV +WEI T G +PYPGV   E++  L++G+R+ +P++C + LY +M  CW 
Sbjct: 590 HQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH 649

Query: 788 LNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGA--AGGADPPTQ 845
             P  RP+F +L EDL+  + AL   QE  ++          +P+   +  + G D    
Sbjct: 650 AVPSQRPTFKQLVEDLDR-IVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFS 708

Query: 846 PDPKDSCSCLTAAEVHPA 863
            +P     CL     HPA
Sbjct: 709 HEPLPEEPCLPR---HPA 723


>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
           [Homo sapiens]
          Length = 820

 Score =  211 bits (538), Expect = 2e-54
 Identities = 138/378 (36%), Positives = 210/378 (55%), Gaps = 31/378 (8%)

Query: 505 SRRTTEATLNSLGISE-ELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQ---LNQD-- 558
           SR ++  T    G+SE EL E  R  +  R ++ LGK LGEG FG V+  +   L++D  
Sbjct: 445 SRLSSSGTPMLAGVSEYELPEDPRWEL-PRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKP 503

Query: 559 DSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFD-HPNVMRLIGVCFQGSERESFPAPV 617
           + + KVAVK +K +  T  +L D +SE   MK    H N++ L+G C Q           
Sbjct: 504 NRVTKVAVKMLK-SDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPL------Y 556

Query: 618 VILPFMKHGDLHSFL----------LYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKR 667
           VI+ +   G+L  +L           Y+   +    L ++ LV     +A GMEYL++K+
Sbjct: 557 VIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKK 616

Query: 668 FIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYT 727
            IHRDLAARN ++ E+  + +ADFGL++ I++ DYY++    ++PVKW+A E+L DR+YT
Sbjct: 617 CIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYT 676

Query: 728 SKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWE 787
            +SDVWSFGV +WEI T G +PYPGV   E++  L++G+R+ +P++C + LY +M  CW 
Sbjct: 677 HQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH 736

Query: 788 LNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGA--AGGADPPTQ 845
             P  RP+F +L EDL+  + AL   QE  ++          +P+   +  + G D    
Sbjct: 737 AVPSQRPTFKQLVEDLDR-IVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFS 795

Query: 846 PDPKDSCSCLTAAEVHPA 863
            +P     CL     HPA
Sbjct: 796 HEPLPEEPCLPR---HPA 810



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 48/224 (21%), Positives = 85/224 (37%), Gaps = 52/224 (23%)

Query: 2   AWRCPRMGRVPLAWCLALCGWACMA-----------PRGTQAEESPFVGNPGNITGARGL 50
           +W+C       L W + +    C A           P G   E   F+ +PG++      
Sbjct: 3   SWKCL------LFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLL----- 51

Query: 51  TGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLS 110
              LRC+L+   +   ++WLRDG  ++LA+S +T++   E E  D +            +
Sbjct: 52  --QLRCRLR--DDVQSINWLRDG--VQLAESNRTRITGEEVEVQDSVP-----------A 94

Query: 111 DTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVD 170
           D+G Y C+      +  +       + LP   ++ +D   ++      + +    P PV 
Sbjct: 95  DSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTK----PNPVA 150

Query: 171 LLWLQDAVPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVT 214
             W        T+P    ++ LH     KT  F C +      T
Sbjct: 151 PYW--------TSP-EKMEKKLHAVPAAKTVKFKCPSSGTPNPT 185


>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
          Length = 1072

 Score =  211 bits (538), Expect = 2e-54
 Identities = 124/329 (37%), Positives = 183/329 (55%), Gaps = 37/329 (11%)

Query: 533  RHKVALGKTLGEGEFGAVMEG---QLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCM 589
            R  + LGKTLGEGEFG V++     L        VAVK +K    + SEL D LSE   +
Sbjct: 721  RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENASPSELRDLLSEFNVL 779

Query: 590  KEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSR------LG----- 638
            K+ +HP+V++L G C Q          ++I+ + K+G L  FL  SR      LG     
Sbjct: 780  KQVNHPHVIKLYGACSQDGPL------LLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSR 833

Query: 639  -----DQPVYLPTQM--LVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADF 691
                 D P      M  L+ F   I+ GM+YL+  + +HRDLAARN ++ E   + ++DF
Sbjct: 834  NSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDF 893

Query: 692  GLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYP 751
            GLS+ +Y  D Y +    ++PVKW+AIESL D +YT++SDVWSFGV +WEI T G  PYP
Sbjct: 894  GLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYP 953

Query: 752  GVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKA-- 809
            G+    +++ L+ G+R+++P +C + +Y LM +CW+  P  RP F ++ +DLE  +    
Sbjct: 954  GIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRR 1013

Query: 810  ----LPPAQEPDEILYVNMDEGGGYPEPP 834
                L  +   D ++Y   D+G    E P
Sbjct: 1014 DYLDLAASTPSDSLIY---DDGLSEEETP 1039


>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
          Length = 1114

 Score =  211 bits (538), Expect = 2e-54
 Identities = 124/329 (37%), Positives = 183/329 (55%), Gaps = 37/329 (11%)

Query: 533  RHKVALGKTLGEGEFGAVMEG---QLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCM 589
            R  + LGKTLGEGEFG V++     L        VAVK +K    + SEL D LSE   +
Sbjct: 721  RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENASPSELRDLLSEFNVL 779

Query: 590  KEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSR------LG----- 638
            K+ +HP+V++L G C Q          ++I+ + K+G L  FL  SR      LG     
Sbjct: 780  KQVNHPHVIKLYGACSQDGPL------LLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSR 833

Query: 639  -----DQPVYLPTQM--LVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADF 691
                 D P      M  L+ F   I+ GM+YL+  + +HRDLAARN ++ E   + ++DF
Sbjct: 834  NSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDF 893

Query: 692  GLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYP 751
            GLS+ +Y  D Y +    ++PVKW+AIESL D +YT++SDVWSFGV +WEI T G  PYP
Sbjct: 894  GLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYP 953

Query: 752  GVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKA-- 809
            G+    +++ L+ G+R+++P +C + +Y LM +CW+  P  RP F ++ +DLE  +    
Sbjct: 954  GIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRR 1013

Query: 810  ----LPPAQEPDEILYVNMDEGGGYPEPP 834
                L  +   D ++Y   D+G    E P
Sbjct: 1014 DYLDLAASTPSDSLIY---DDGLSEEETP 1039


>gi|105990522 fibroblast growth factor receptor 1 isoform 1
           precursor [Homo sapiens]
          Length = 822

 Score =  211 bits (538), Expect = 2e-54
 Identities = 138/378 (36%), Positives = 210/378 (55%), Gaps = 31/378 (8%)

Query: 505 SRRTTEATLNSLGISE-ELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQ---LNQD-- 558
           SR ++  T    G+SE EL E  R  +  R ++ LGK LGEG FG V+  +   L++D  
Sbjct: 447 SRLSSSGTPMLAGVSEYELPEDPRWEL-PRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKP 505

Query: 559 DSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFD-HPNVMRLIGVCFQGSERESFPAPV 617
           + + KVAVK +K +  T  +L D +SE   MK    H N++ L+G C Q           
Sbjct: 506 NRVTKVAVKMLK-SDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPL------Y 558

Query: 618 VILPFMKHGDLHSFL----------LYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKR 667
           VI+ +   G+L  +L           Y+   +    L ++ LV     +A GMEYL++K+
Sbjct: 559 VIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKK 618

Query: 668 FIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYT 727
            IHRDLAARN ++ E+  + +ADFGL++ I++ DYY++    ++PVKW+A E+L DR+YT
Sbjct: 619 CIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYT 678

Query: 728 SKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWE 787
            +SDVWSFGV +WEI T G +PYPGV   E++  L++G+R+ +P++C + LY +M  CW 
Sbjct: 679 HQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH 738

Query: 788 LNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGA--AGGADPPTQ 845
             P  RP+F +L EDL+  + AL   QE  ++          +P+   +  + G D    
Sbjct: 739 AVPSQRPTFKQLVEDLDR-IVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFS 797

Query: 846 PDPKDSCSCLTAAEVHPA 863
            +P     CL     HPA
Sbjct: 798 HEPLPEEPCLPR---HPA 812



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 32/128 (25%), Positives = 55/128 (42%), Gaps = 39/128 (30%)

Query: 2   AWRCPRMGRVPLAWCLALCGWACMA-----------PRGTQAEESPFVGNPGNITGARGL 50
           +W+C       L W + +    C A           P G   E   F+ +PG++      
Sbjct: 3   SWKCL------LFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLL----- 51

Query: 51  TGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLS 110
              LRC+L+   +   ++WLRDG  ++LA+S +T++   E E  D +            +
Sbjct: 52  --QLRCRLR--DDVQSINWLRDG--VQLAESNRTRITGEEVEVQDSVP-----------A 94

Query: 111 DTGQYQCL 118
           D+G Y C+
Sbjct: 95  DSGLYACV 102


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.424 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,715,021
Number of Sequences: 37866
Number of extensions: 2293396
Number of successful extensions: 12449
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 594
Number of HSP's successfully gapped in prelim test: 460
Number of HSP's that attempted gapping in prelim test: 8871
Number of HSP's gapped (non-prelim): 2640
length of query: 894
length of database: 18,247,518
effective HSP length: 111
effective length of query: 783
effective length of database: 14,044,392
effective search space: 10996758936
effective search space used: 10996758936
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.