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Search of human proteins with 21450785
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21450785 suppressor of cytokine signaling 6 [Homo sapiens]
(535 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21450785 suppressor of cytokine signaling 6 [Homo sapiens] 1082 0.0
gi|53831997 suppressor of cytokine signaling 7 [Homo sapiens] 172 5e-43
gi|21618354 suppressor of cytokine signaling 5 [Homo sapiens] 102 9e-22
gi|7662240 suppressor of cytokine signaling 5 [Homo sapiens] 102 9e-22
gi|4507263 suppressor of cytokine signaling-2 [Homo sapiens] 97 5e-20
gi|40807480 suppressor of cytokine signaling 4 [Homo sapiens] 96 6e-20
gi|18254466 suppressor of cytokine signaling 4 [Homo sapiens] 96 6e-20
gi|195976771 cytokine-inducible SH2-containing protein isoform 1... 84 3e-16
gi|21614507 cytokine-inducible SH2-containing protein isoform 2 ... 84 3e-16
gi|45439352 suppressor of cytokine signaling 3 [Homo sapiens] 65 1e-10
gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 59 1e-08
gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 59 1e-08
gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta... 58 2e-08
gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 56 9e-08
gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 55 2e-07
gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 55 2e-07
gi|4507233 suppressor of cytokine signaling 1 [Homo sapiens] 53 6e-07
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 50 4e-06
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 50 4e-06
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 50 4e-06
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 50 4e-06
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 50 4e-06
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit... 50 4e-06
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 48 3e-05
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 46 7e-05
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 46 7e-05
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 44 5e-04
gi|187475373 c-src tyrosine kinase [Homo sapiens] 43 8e-04
gi|4758078 c-src tyrosine kinase [Homo sapiens] 43 8e-04
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 43 8e-04
>gi|21450785 suppressor of cytokine signaling 6 [Homo sapiens]
Length = 535
Score = 1082 bits (2797), Expect = 0.0
Identities = 535/535 (100%), Positives = 535/535 (100%)
Query: 1 MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGED 60
MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGED
Sbjct: 1 MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGED 60
Query: 61 EKGGKNRSKSESLMGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDVRAQR 120
EKGGKNRSKSESLMGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDVRAQR
Sbjct: 61 EKGGKNRSKSESLMGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDVRAQR 120
Query: 121 PIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQS 180
PIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQS
Sbjct: 121 PIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQS 180
Query: 181 ETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSY 240
ETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSY
Sbjct: 181 ETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSY 240
Query: 241 CLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSP 300
CLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSP
Sbjct: 241 CLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSP 300
Query: 301 RAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDS 360
RAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDS
Sbjct: 301 RAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDS 360
Query: 361 VQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSL 420
VQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSL
Sbjct: 361 VQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSL 420
Query: 421 SFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGS 480
SFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGS
Sbjct: 421 SFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGS 480
Query: 481 ATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY 535
ATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY
Sbjct: 481 ATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY 535
>gi|53831997 suppressor of cytokine signaling 7 [Homo sapiens]
Length = 581
Score = 172 bits (437), Expect = 5e-43
Identities = 119/303 (39%), Positives = 159/303 (52%), Gaps = 24/303 (7%)
Query: 257 VGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTG--VMLQSPRAGHDDVPPLSPLL 314
+GG A E ++ L F S + L G T V + + G P +P
Sbjct: 251 MGGSAGRELDAGRKPKLTRTQSAFSPVSFSPLFTGETVSLVDVDISQRGLTSPHPPTPPP 310
Query: 315 PPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFD---------PNSAPGVA--RVYDSVQS 363
PP ++ + + SG T VA +F P++ P +A R +S+ S
Sbjct: 311 PPRRSLSLLDDISGTLPTSVLVAPMGSSLQSFPLPPPPPPHAPDAFPRIAPIRAAESLHS 370
Query: 364 SGPMVV---------TSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDD 414
P + +S L++L K GWYWGP+ +AE KL PDGSFLVRDSSD
Sbjct: 371 QPPQHLQCPLYRPDSSSFAASLRELEKCGWYWGPMNWEDAEMKLKGKPDGSFLVRDSSDP 430
Query: 415 RYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGH-TSIVDLIEHSIRDSENGAFCY- 472
RY+LSLSFRS G T HTR+EH G FS + P E S+V+ I+ +I S+NG F Y
Sbjct: 431 RYILSLSFRSQGITHHTRMEHYRGTFSLWCHPKFEDRCQSVVEFIKRAIMHSKNGKFLYF 490
Query: 473 SRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQE 532
RSR+PG PV+L PVSRF V+SLQ+LCRF IRQ RID I LPLP + Y+++
Sbjct: 491 LRSRVPGLPPTPVQLLYPVSRFSNVKSLQHLCRFRIRQLVRIDHIPDLPLPKPLISYIRK 550
Query: 533 KHY 535
+Y
Sbjct: 551 FYY 553
>gi|21618354 suppressor of cytokine signaling 5 [Homo sapiens]
Length = 536
Score = 102 bits (254), Expect = 9e-22
Identities = 61/165 (36%), Positives = 91/165 (55%), Gaps = 15/165 (9%)
Query: 372 LTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHT 431
L +L ++ YWG + R+EAE L P+G+FL+RDS+ + YL S+SFR + ++LH
Sbjct: 369 LVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHA 428
Query: 432 RIEHSNGRFSF-YEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNP 490
RIE N FSF P V +++ L+EH +D + F + + T+P
Sbjct: 429 RIEQWNHNFSFDAHDPCVFHSSTVTGLLEH-YKDPSSCMFFEPLLTISLNRTFPF----- 482
Query: 491 VSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY 535
SLQY+CR VI + T D I LPLP+ ++D+L+E HY
Sbjct: 483 --------SLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHY 519
>gi|7662240 suppressor of cytokine signaling 5 [Homo sapiens]
Length = 536
Score = 102 bits (254), Expect = 9e-22
Identities = 61/165 (36%), Positives = 91/165 (55%), Gaps = 15/165 (9%)
Query: 372 LTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHT 431
L +L ++ YWG + R+EAE L P+G+FL+RDS+ + YL S+SFR + ++LH
Sbjct: 369 LVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHA 428
Query: 432 RIEHSNGRFSF-YEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNP 490
RIE N FSF P V +++ L+EH +D + F + + T+P
Sbjct: 429 RIEQWNHNFSFDAHDPCVFHSSTVTGLLEH-YKDPSSCMFFEPLLTISLNRTFPF----- 482
Query: 491 VSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY 535
SLQY+CR VI + T D I LPLP+ ++D+L+E HY
Sbjct: 483 --------SLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHY 519
>gi|4507263 suppressor of cytokine signaling-2 [Homo sapiens]
Length = 198
Score = 96.7 bits (239), Expect = 5e-20
Identities = 59/168 (35%), Positives = 93/168 (55%), Gaps = 17/168 (10%)
Query: 372 LTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHT 431
L + L++L + GWYWG +T EA+ KL P+G+FL+RDSS YLL++S ++ +
Sbjct: 36 LAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNL 95
Query: 432 RIEHSNGRFSFYE----QPDVEGHTSIVDLIEHSI---RDSENGAFCYSRSRLPGSATYP 484
RIE+ +G+F + ++ S+V LI++ + +D G P + T
Sbjct: 96 RIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTG------PEAPRNGTVH 149
Query: 485 VRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQE 532
+ LT P+ + SLQ+LCR I + T I LPLP ++KDYL+E
Sbjct: 150 LYLTKPL--YTSAPSLQHLCRLTINKCT--GAIWGLPLPTRLKDYLEE 193
>gi|40807480 suppressor of cytokine signaling 4 [Homo sapiens]
Length = 440
Score = 96.3 bits (238), Expect = 6e-20
Identities = 62/168 (36%), Positives = 85/168 (50%), Gaps = 15/168 (8%)
Query: 369 VTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKT 428
V L +L ++ YWG + ++ AE L P+G+FL+RDS+ + YL S+SFR + ++
Sbjct: 271 VHCLVPDLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRS 330
Query: 429 LHTRIEHSNGRFSF-YEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRL 487
LH RIE N FSF P V I L+EH +D F P T+P
Sbjct: 331 LHARIEQWNHNFSFDAHDPCVFHSPDITGLLEH-YKDPSACMFFEPLLSTPLIRTFPF-- 387
Query: 488 TNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY 535
SLQ++CR VI T D I LP+P+ MK YL+E HY
Sbjct: 388 -----------SLQHICRTVICNCTTYDGIDALPIPSSMKLYLKEYHY 424
>gi|18254466 suppressor of cytokine signaling 4 [Homo sapiens]
Length = 440
Score = 96.3 bits (238), Expect = 6e-20
Identities = 62/168 (36%), Positives = 85/168 (50%), Gaps = 15/168 (8%)
Query: 369 VTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKT 428
V L +L ++ YWG + ++ AE L P+G+FL+RDS+ + YL S+SFR + ++
Sbjct: 271 VHCLVPDLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRS 330
Query: 429 LHTRIEHSNGRFSF-YEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRL 487
LH RIE N FSF P V I L+EH +D F P T+P
Sbjct: 331 LHARIEQWNHNFSFDAHDPCVFHSPDITGLLEH-YKDPSACMFFEPLLSTPLIRTFPF-- 387
Query: 488 TNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY 535
SLQ++CR VI T D I LP+P+ MK YL+E HY
Sbjct: 388 -----------SLQHICRTVICNCTTYDGIDALPIPSSMKLYLKEYHY 424
>gi|195976771 cytokine-inducible SH2-containing protein isoform 1
[Homo sapiens]
Length = 275
Score = 84.0 bits (206), Expect = 3e-16
Identities = 54/179 (30%), Positives = 84/179 (46%), Gaps = 27/179 (15%)
Query: 379 LAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNG 438
L + GWYWG IT EA L +P+G+FLVRDS+ YL +LS ++ + RIE+++
Sbjct: 94 LRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADS 153
Query: 439 RF----SFYEQPDVEGHTSIVDLIEHSIRD------------SENGAFCYSRSRLPGSAT 482
F + +P + +V L++H + + A + P
Sbjct: 154 SFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMPKEDAPSDPA 213
Query: 483 YP---------VRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQE 532
P ++L P R RSLQ+LCR VI + + + LPLP +M DYL++
Sbjct: 214 LPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVINRL--VADVDCLPLPRRMADYLRQ 270
>gi|21614507 cytokine-inducible SH2-containing protein isoform 2
[Homo sapiens]
Length = 258
Score = 84.0 bits (206), Expect = 3e-16
Identities = 54/179 (30%), Positives = 84/179 (46%), Gaps = 27/179 (15%)
Query: 379 LAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNG 438
L + GWYWG IT EA L +P+G+FLVRDS+ YL +LS ++ + RIE+++
Sbjct: 77 LRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADS 136
Query: 439 RF----SFYEQPDVEGHTSIVDLIEHSIRD------------SENGAFCYSRSRLPGSAT 482
F + +P + +V L++H + + A + P
Sbjct: 137 SFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMPKEDAPSDPA 196
Query: 483 YP---------VRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQE 532
P ++L P R RSLQ+LCR VI + + + LPLP +M DYL++
Sbjct: 197 LPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVINRL--VADVDCLPLPRRMADYLRQ 253
>gi|45439352 suppressor of cytokine signaling 3 [Homo sapiens]
Length = 225
Score = 65.5 bits (158), Expect = 1e-10
Identities = 54/187 (28%), Positives = 88/187 (47%), Gaps = 34/187 (18%)
Query: 376 LKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEH 435
++KL + G+YW +T EA L+ P G+FL+RDSSD R+ +LS ++ T + RI+
Sbjct: 38 VRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQC 97
Query: 436 SNGRFSFYEQP----DVEGHTSIVDLIEHSIRDSENGAFCY-------------SRSRLP 478
G FS P V ++ L+ H + +F S LP
Sbjct: 98 EGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLP 157
Query: 479 GS----ATY--------PVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKL-PLPNK 525
GS A Y P+ L+ P+S V +LQ+LCR + + +D +K+ LP
Sbjct: 158 GSPPRRAYYIYSGGEKIPLVLSRPLS--SNVATLQHLCRKTVNGH--LDSYEKVTQLPGP 213
Query: 526 MKDYLQE 532
++++L +
Sbjct: 214 IREFLDQ 220
>gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 58.9 bits (141), Expect = 1e-08
Identities = 39/114 (34%), Positives = 57/114 (50%), Gaps = 14/114 (12%)
Query: 384 WYWGPITRWEAEGKLANVPDGSFLVRDSSDD-RYLLSLSFRSHGKTLHTRIEHSNGRFSF 442
WYWG I+R E KL ++PDG+FLVRD+S + +L+ R G +I H +G++ F
Sbjct: 65 WYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGF 124
Query: 443 YEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQ 496
D S+V+LI H + S + V+L PVSR+ Q
Sbjct: 125 ---SDPLTFNSVVELINH----------YHHESLAQYNPKLDVKLMYPVSRYQQ 165
Score = 35.8 bits (81), Expect = 0.10
Identities = 25/87 (28%), Positives = 45/87 (51%), Gaps = 3/87 (3%)
Query: 374 EELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRI 433
E L ++ W+ I R +AE L PDG+FL+R+SS + + S + G+ H I
Sbjct: 348 ENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESS-KKGCYACSVVADGEVKHCVI 406
Query: 434 EHSNGRFSFYEQPDVEGHTSIVDLIEH 460
+ + F E ++ ++S+ +L+ H
Sbjct: 407 YSTARGYGFAEPYNL--YSSLKELVLH 431
>gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 58.9 bits (141), Expect = 1e-08
Identities = 39/114 (34%), Positives = 57/114 (50%), Gaps = 14/114 (12%)
Query: 384 WYWGPITRWEAEGKLANVPDGSFLVRDSSDD-RYLLSLSFRSHGKTLHTRIEHSNGRFSF 442
WYWG I+R E KL ++PDG+FLVRD+S + +L+ R G +I H +G++ F
Sbjct: 65 WYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGF 124
Query: 443 YEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQ 496
D S+V+LI H + S + V+L PVSR+ Q
Sbjct: 125 ---SDPLTFNSVVELINH----------YHHESLAQYNPKLDVKLMYPVSRYQQ 165
Score = 35.8 bits (81), Expect = 0.10
Identities = 25/87 (28%), Positives = 45/87 (51%), Gaps = 3/87 (3%)
Query: 374 EELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRI 433
E L ++ W+ I R +AE L PDG+FL+R+SS + + S + G+ H I
Sbjct: 348 ENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESS-KKGCYACSVVADGEVKHCVI 406
Query: 434 EHSNGRFSFYEQPDVEGHTSIVDLIEH 460
+ + F E ++ ++S+ +L+ H
Sbjct: 407 YSTARGYGFAEPYNL--YSSLKELVLH 431
>gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
[Homo sapiens]
Length = 728
Score = 58.2 bits (139), Expect = 2e-08
Identities = 40/114 (35%), Positives = 55/114 (48%), Gaps = 14/114 (12%)
Query: 384 WYWGPITRWEAEGKLANVPDGSFLVRD-SSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSF 442
WYWG I+R E KL + PDG+FLVRD SS + +L+ R G ++ H +G + F
Sbjct: 330 WYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGF 389
Query: 443 YEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQ 496
E S+VDLI H + S +A RL PVS++ Q
Sbjct: 390 SEPLT---FCSVVDLINHYRHE----------SLAQYNAKLDTRLLYPVSKYQQ 430
Score = 43.5 bits (101), Expect = 5e-04
Identities = 34/117 (29%), Positives = 55/117 (47%), Gaps = 7/117 (5%)
Query: 374 EELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRI 433
++L ++ WY G I R +AE L+ DG+FL+R+SS R + S G T H I
Sbjct: 612 DDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESS-QRGCYACSVVVDGDTKHCVI 670
Query: 434 EHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNP 490
+ F F E ++ G S+ +L+ H ++ + L + +PVR P
Sbjct: 671 YRTATGFGFAEPYNLYG--SLKELVLH----YQHASLVQHNDALTVTLAHPVRAPGP 721
>gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 2 [Homo sapiens]
Length = 454
Score = 55.8 bits (133), Expect = 9e-08
Identities = 46/166 (27%), Positives = 75/166 (45%), Gaps = 21/166 (12%)
Query: 332 TEAHVAESMRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITR 391
T+ + + ++ DP + P +V ++G SL + WYWG I+R
Sbjct: 18 TDINCGTDLMFYIEMDPPALPPKPPKPTTVANNGMNNNMSLQDA-------EWYWGDISR 70
Query: 392 WEAEGKLANVPDGSFLVRDSSDDRY-LLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEG 450
E KL + DG+FLVRD+S + +L+ R G +I H +G++ F D
Sbjct: 71 EEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGF---SDPLT 127
Query: 451 HTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQ 496
+S+V+LI H N + +L V+L PVS++ Q
Sbjct: 128 FSSVVELINH----YRNESLAQYNPKL------DVKLLYPVSKYQQ 163
Score = 30.8 bits (68), Expect = 3.2
Identities = 25/87 (28%), Positives = 43/87 (49%), Gaps = 3/87 (3%)
Query: 374 EELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRI 433
E+L ++ W G R +AE L DG+FLVR+SS + + S G+ H I
Sbjct: 344 EDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESS-KQGCYACSVVVDGEVKHCVI 402
Query: 434 EHSNGRFSFYEQPDVEGHTSIVDLIEH 460
+ + F E ++ ++S+ +L+ H
Sbjct: 403 NKTATGYGFAEPYNL--YSSLKELVLH 427
>gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 3 [Homo sapiens]
Length = 424
Score = 55.1 bits (131), Expect = 2e-07
Identities = 38/114 (33%), Positives = 57/114 (50%), Gaps = 14/114 (12%)
Query: 384 WYWGPITRWEAEGKLANVPDGSFLVRDSSDDRY-LLSLSFRSHGKTLHTRIEHSNGRFSF 442
WYWG I+R E KL + DG+FLVRD+S + +L+ R G +I H +G++ F
Sbjct: 33 WYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGF 92
Query: 443 YEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQ 496
D +S+V+LI H N + +L V+L PVS++ Q
Sbjct: 93 ---SDPLTFSSVVELINH----YRNESLAQYNPKL------DVKLLYPVSKYQQ 133
Score = 30.8 bits (68), Expect = 3.2
Identities = 25/87 (28%), Positives = 43/87 (49%), Gaps = 3/87 (3%)
Query: 374 EELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRI 433
E+L ++ W G R +AE L DG+FLVR+SS + + S G+ H I
Sbjct: 314 EDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESS-KQGCYACSVVVDGEVKHCVI 372
Query: 434 EHSNGRFSFYEQPDVEGHTSIVDLIEH 460
+ + F E ++ ++S+ +L+ H
Sbjct: 373 NKTATGYGFAEPYNL--YSSLKELVLH 397
>gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 1 [Homo sapiens]
Length = 724
Score = 55.1 bits (131), Expect = 2e-07
Identities = 38/114 (33%), Positives = 57/114 (50%), Gaps = 14/114 (12%)
Query: 384 WYWGPITRWEAEGKLANVPDGSFLVRDSSDDRY-LLSLSFRSHGKTLHTRIEHSNGRFSF 442
WYWG I+R E KL + DG+FLVRD+S + +L+ R G +I H +G++ F
Sbjct: 333 WYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGF 392
Query: 443 YEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQ 496
D +S+V+LI H N + +L V+L PVS++ Q
Sbjct: 393 ---SDPLTFSSVVELINH----YRNESLAQYNPKL------DVKLLYPVSKYQQ 433
Score = 30.8 bits (68), Expect = 3.2
Identities = 25/87 (28%), Positives = 43/87 (49%), Gaps = 3/87 (3%)
Query: 374 EELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRI 433
E+L ++ W G R +AE L DG+FLVR+SS + + S G+ H I
Sbjct: 614 EDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESS-KQGCYACSVVVDGEVKHCVI 672
Query: 434 EHSNGRFSFYEQPDVEGHTSIVDLIEH 460
+ + F E ++ ++S+ +L+ H
Sbjct: 673 NKTATGYGFAEPYNL--YSSLKELVLH 697
>gi|4507233 suppressor of cytokine signaling 1 [Homo sapiens]
Length = 211
Score = 53.1 bits (126), Expect = 6e-07
Identities = 41/148 (27%), Positives = 62/148 (41%), Gaps = 21/148 (14%)
Query: 383 GWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSF 442
G+YWGP++ A +L P G+FLVRDS +LS + R+ GR F
Sbjct: 78 GFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGR--F 135
Query: 443 YEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQY 502
+ E + +L+EH + P R+ R +VR LQ
Sbjct: 136 HLDGSRESFDCLFELLEHYV-------------------AAPRRMLGAPLRQRRVRPLQE 176
Query: 503 LCRFVIRQYTRIDLIQKLPLPNKMKDYL 530
LCR I + + ++PL ++DYL
Sbjct: 177 LCRQRIVATVGRENLARIPLNPVLRDYL 204
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 50.4 bits (119), Expect = 4e-06
Identities = 25/58 (43%), Positives = 35/58 (60%)
Query: 376 LKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRI 433
+ L K WY GP++R AE L+++ +GSFLVR+S LS+S R G+ H RI
Sbjct: 150 VNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRI 207
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 50.4 bits (119), Expect = 4e-06
Identities = 25/58 (43%), Positives = 35/58 (60%)
Query: 376 LKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRI 433
+ L K WY GP++R AE L+++ +GSFLVR+S LS+S R G+ H RI
Sbjct: 165 VNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRI 222
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 50.4 bits (119), Expect = 4e-06
Identities = 25/58 (43%), Positives = 35/58 (60%)
Query: 376 LKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRI 433
+ L K WY GP++R AE L+++ +GSFLVR+S LS+S R G+ H RI
Sbjct: 144 VNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRI 201
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 50.4 bits (119), Expect = 4e-06
Identities = 25/58 (43%), Positives = 35/58 (60%)
Query: 376 LKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRI 433
+ L K WY GP++R AE L+++ +GSFLVR+S LS+S R G+ H RI
Sbjct: 150 VNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRI 207
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 50.4 bits (119), Expect = 4e-06
Identities = 25/58 (43%), Positives = 35/58 (60%)
Query: 376 LKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRI 433
+ L K WY GP++R AE L+++ +GSFLVR+S LS+S R G+ H RI
Sbjct: 129 VNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRI 186
>gi|158631203 dual adaptor of phosphotyrosine and
3-phosphoinositides [Homo sapiens]
Length = 280
Score = 50.4 bits (119), Expect = 4e-06
Identities = 31/87 (35%), Positives = 46/87 (52%), Gaps = 5/87 (5%)
Query: 375 ELKKLAKQGWYWGPITRWEAEGKL-ANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRI 433
E + L GWY G +TR AE L +N DGS+L+RDS++ L SLS R+ H +
Sbjct: 26 EAELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHV 85
Query: 434 EHSNGRFSFYEQPDVEGHTSIVDLIEH 460
E++ F F +S+ D ++H
Sbjct: 86 EYTGYSFKF----GFNEFSSLKDFVKH 108
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 47.8 bits (112), Expect = 3e-05
Identities = 27/82 (32%), Positives = 44/82 (53%), Gaps = 1/82 (1%)
Query: 384 WYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFY 443
WY GP+ R AE LAN DG+FLVR D ++S + + + H +I + G +
Sbjct: 671 WYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRIT 730
Query: 444 EQPDVEGHTSIVDLI-EHSIRD 464
E+ G T +V+ ++S++D
Sbjct: 731 EKKAFRGLTELVEFYQQNSLKD 752
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 46.2 bits (108), Expect = 7e-05
Identities = 24/58 (41%), Positives = 33/58 (56%)
Query: 376 LKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRI 433
+ L K WY GP++R AE L++ +GSFLVR+S S+S R G+ H RI
Sbjct: 119 VNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRI 176
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 46.2 bits (108), Expect = 7e-05
Identities = 24/58 (41%), Positives = 33/58 (56%)
Query: 376 LKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRI 433
+ L K WY GP++R AE L++ +GSFLVR+S S+S R G+ H RI
Sbjct: 138 VNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRI 195
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 43.5 bits (101), Expect = 5e-04
Identities = 28/82 (34%), Positives = 40/82 (48%), Gaps = 5/82 (6%)
Query: 384 WYWGPITRWEAEGKLANVP-DGSFLVRD-SSDDRYLLSLSFRSHGKTLHTRIEHSNGRFS 441
WY+ ++R EAE L +P DG+FL+R D Y +++FR+ GK H RI F
Sbjct: 646 WYYDSLSRGEAEDMLMRIPRDGAFLIRKREGSDSY--AITFRARGKVKHCRINRDGRHFV 703
Query: 442 FYEQPDVEGHTSIVDLIE-HSI 462
E +V E HS+
Sbjct: 704 LGTSAYFESLVELVSYYEKHSL 725
Score = 32.3 bits (72), Expect = 1.1
Identities = 29/91 (31%), Positives = 43/91 (47%), Gaps = 15/91 (16%)
Query: 403 DGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHS--NGRFSFYEQPDVEGHTSIVDLIEH 460
DG+FLVR+S +LSF G+ H RI + G +Y ++ +SI LI+H
Sbjct: 558 DGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYYLTDNLT-FSSIYALIQH 616
Query: 461 SIRDSENGAFCYSRSRLPGSATYPVRLTNPV 491
Y + L A + +RLT+PV
Sbjct: 617 -----------YRETHL-RCAEFELRLTDPV 635
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 42.7 bits (99), Expect = 8e-04
Identities = 29/89 (32%), Positives = 45/89 (50%), Gaps = 3/89 (3%)
Query: 378 KLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSN 437
KL+ W+ G ITR +AE L G FLVR+S++ +L GK H RI +
Sbjct: 76 KLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHA 135
Query: 438 GRFSFYEQPDVEGHTSIVDLIEHSIRDSE 466
+ S E+ E +++ L+EH D++
Sbjct: 136 SKLSIDEEVYFE---NLMQLVEHYTSDAD 161
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 42.7 bits (99), Expect = 8e-04
Identities = 29/89 (32%), Positives = 45/89 (50%), Gaps = 3/89 (3%)
Query: 378 KLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSN 437
KL+ W+ G ITR +AE L G FLVR+S++ +L GK H RI +
Sbjct: 76 KLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHA 135
Query: 438 GRFSFYEQPDVEGHTSIVDLIEHSIRDSE 466
+ S E+ E +++ L+EH D++
Sbjct: 136 SKLSIDEEVYFE---NLMQLVEHYTSDAD 161
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 42.7 bits (99), Expect = 8e-04
Identities = 31/96 (32%), Positives = 49/96 (51%), Gaps = 9/96 (9%)
Query: 378 KLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSS--DDRYLLSLSFRSHGKTLHTRIEH 435
KL+ W+ G I+ EA +L DG FLVR+S+ Y+L +SF +H R+ H
Sbjct: 75 KLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGR--DVIHYRVLH 132
Query: 436 SNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFC 471
+G + E +++D++EH +D GA C
Sbjct: 133 RDGHLTIDE---AVFFCNLMDMVEHYSKD--KGAIC 163
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,458,050
Number of Sequences: 37866
Number of extensions: 1024693
Number of successful extensions: 2708
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 61
Number of HSP's successfully gapped in prelim test: 91
Number of HSP's that attempted gapping in prelim test: 2577
Number of HSP's gapped (non-prelim): 195
length of query: 535
length of database: 18,247,518
effective HSP length: 107
effective length of query: 428
effective length of database: 14,195,856
effective search space: 6075826368
effective search space used: 6075826368
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.