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Search of human proteins with 21389431
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
(335 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 667 0.0
gi|190014581 leucine rich repeat containing 2 [Homo sapiens] 191 8e-49
gi|27545328 leucine rich repeat containing 2 [Homo sapiens] 191 8e-49
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 131 1e-30
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 116 2e-26
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 114 2e-25
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 114 2e-25
gi|45827729 scribble isoform b [Homo sapiens] 111 8e-25
gi|45827731 scribble isoform a [Homo sapiens] 111 8e-25
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 111 8e-25
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 106 3e-23
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 106 3e-23
gi|238908508 leucine-rich repeat and death domain-containing pro... 106 3e-23
gi|157743290 leucine rich repeat containing 30 [Homo sapiens] 105 7e-23
gi|63003903 leucine rich repeat containing 10 [Homo sapiens] 101 1e-21
gi|4503743 flightless I homolog [Homo sapiens] 97 3e-20
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 96 5e-20
gi|62241040 leucine rich repeat containing 8 family, member A [H... 93 3e-19
gi|187829877 leucine rich repeat containing 8 family, member A [... 93 3e-19
gi|187829871 leucine rich repeat containing 8 family, member A [... 93 3e-19
gi|197333706 leucine rich repeat containing 8 family, member D [... 91 2e-18
gi|34222199 leucine rich repeat containing 8 family, member D [H... 91 2e-18
gi|193788651 leucine rich repeat containing 69 [Homo sapiens] 91 2e-18
gi|40217803 leucine rich repeat containing 8 family, member E [H... 87 2e-17
gi|14249428 leucine-rich repeats and calponin homology (CH) doma... 87 2e-17
gi|154091020 leucine-rich repeats and calponin homology (CH) dom... 87 2e-17
gi|61742786 leucine rich repeat and death domain containing prot... 87 3e-17
gi|61742784 leucine rich repeat and death domain containing prot... 87 3e-17
gi|197333692 leucine rich repeat containing 8 family, member B [... 86 4e-17
gi|21245134 leucine rich repeat containing 8 family, member B [H... 86 4e-17
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 667 bits (1722), Expect = 0.0
Identities = 335/335 (100%), Positives = 335/335 (100%)
Query: 1 MTENVVCTGAVNAVKEVWEKRIKKLNEDLKREKEFQHKLVRIWEERVSLTKLREKVTRED 60
MTENVVCTGAVNAVKEVWEKRIKKLNEDLKREKEFQHKLVRIWEERVSLTKLREKVTRED
Sbjct: 1 MTENVVCTGAVNAVKEVWEKRIKKLNEDLKREKEFQHKLVRIWEERVSLTKLREKVTRED 60
Query: 61 GRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISE 120
GRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISE
Sbjct: 61 GRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISE 120
Query: 121 IPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTH 180
IPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTH
Sbjct: 121 IPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTH 180
Query: 181 LDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQT 240
LDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQT
Sbjct: 181 LDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQT 240
Query: 241 ISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEGTDEEEEREL 300
ISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEGTDEEEEREL
Sbjct: 241 ISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEGTDEEEEREL 300
Query: 301 FGLQFMHTYIQESRRRADHQVNGSTTLPISINTDG 335
FGLQFMHTYIQESRRRADHQVNGSTTLPISINTDG
Sbjct: 301 FGLQFMHTYIQESRRRADHQVNGSTTLPISINTDG 335
>gi|190014581 leucine rich repeat containing 2 [Homo sapiens]
Length = 371
Score = 191 bits (485), Expect = 8e-49
Identities = 108/318 (33%), Positives = 186/318 (58%), Gaps = 12/318 (3%)
Query: 10 AVNAVKEVW----EKRIKKLNEDLKREKEFQHKLVRIWE--ERVSLTKLREKVTREDGR- 62
A+ +KE W E R K + + + + F VR+ + ER +LT+ + + ++ G+
Sbjct: 39 ALEKIKEEWNFVAECRRKGIPQAVYCKNGFIDTSVRLLDKIERNTLTR-QSSLPKDRGKR 97
Query: 63 ---VILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTIS 119
+ ++ E W LP SL + L+EW + T + IP +I FQ + +LDL +N IS
Sbjct: 98 SSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQIS 157
Query: 120 EIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLT 179
+P IG L L+EL + +N +K++P EL +C +LE+L+ + N ++ +LP ELSNL ++T
Sbjct: 158 HLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVT 217
Query: 180 HLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQ 239
+D+S N F+++P+ VL M L+WLD+ SN L LP I+R++ L + L +N++T LP
Sbjct: 218 FVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPY 277
Query: 240 TISNMKNLGTLVLSNNKLQDIPVCM-EEMANLRFVNFRDNPLKLKVSLPPSEGTDEEEER 298
++ N+K L LV+S + L ++P + + L+FV+ DNP+ +E + E +R
Sbjct: 278 SMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDNPIDNAQCEDGNEIMESERDR 337
Query: 299 ELFGLQFMHTYIQESRRR 316
+ F + M YI++ + R
Sbjct: 338 QHFDKEVMKAYIEDLKER 355
>gi|27545328 leucine rich repeat containing 2 [Homo sapiens]
Length = 371
Score = 191 bits (485), Expect = 8e-49
Identities = 108/318 (33%), Positives = 186/318 (58%), Gaps = 12/318 (3%)
Query: 10 AVNAVKEVW----EKRIKKLNEDLKREKEFQHKLVRIWE--ERVSLTKLREKVTREDGR- 62
A+ +KE W E R K + + + + F VR+ + ER +LT+ + + ++ G+
Sbjct: 39 ALEKIKEEWNFVAECRRKGIPQAVYCKNGFIDTSVRLLDKIERNTLTR-QSSLPKDRGKR 97
Query: 63 ---VILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTIS 119
+ ++ E W LP SL + L+EW + T + IP +I FQ + +LDL +N IS
Sbjct: 98 SSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQIS 157
Query: 120 EIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLT 179
+P IG L L+EL + +N +K++P EL +C +LE+L+ + N ++ +LP ELSNL ++T
Sbjct: 158 HLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVT 217
Query: 180 HLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQ 239
+D+S N F+++P+ VL M L+WLD+ SN L LP I+R++ L + L +N++T LP
Sbjct: 218 FVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPY 277
Query: 240 TISNMKNLGTLVLSNNKLQDIPVCM-EEMANLRFVNFRDNPLKLKVSLPPSEGTDEEEER 298
++ N+K L LV+S + L ++P + + L+FV+ DNP+ +E + E +R
Sbjct: 278 SMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDNPIDNAQCEDGNEIMESERDR 337
Query: 299 ELFGLQFMHTYIQESRRR 316
+ F + M YI++ + R
Sbjct: 338 QHFDKEVMKAYIEDLKER 355
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 131 bits (329), Expect = 1e-30
Identities = 80/218 (36%), Positives = 120/218 (55%), Gaps = 1/218 (0%)
Query: 64 ILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPP 123
IL++ + KTLP S+ KL QL+ L ++PE + + QNL L + N + +P
Sbjct: 165 ILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPG 224
Query: 124 GIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDL 183
IG L L L +S N+I+TV ++S C +LE L L+ N + LP + L KLT L +
Sbjct: 225 SIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNM-LQQLPDSIGLLKKLTTLKV 283
Query: 184 SMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN 243
N T +P + N+ LE D N+LE LP TI + +L TL + N + LP+ I +
Sbjct: 284 DDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGS 343
Query: 244 MKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLK 281
KN+ + L +NKL+ +P + +M LR +N DN LK
Sbjct: 344 CKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLK 381
Score = 101 bits (251), Expect = 1e-21
Identities = 77/289 (26%), Positives = 133/289 (46%), Gaps = 45/289 (15%)
Query: 35 FQHKLVRIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTG 94
F+ L ++ + + +L +++ L I + LP+++ L L+E + + G
Sbjct: 44 FERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNG 103
Query: 95 LLKIPEFIGRFQNLIVLDLSRNTISEIPPG-----------------------IGLLTRL 131
+ + PE I + L +++ S N IS++P G G L +L
Sbjct: 104 VQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKL 163
Query: 132 QELILSYNKIKTVPKELSNCASLEKLELAVNR-----DICD-----------------LP 169
+ L L N +KT+PK + A LE+L+L N ++ D LP
Sbjct: 164 RILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLP 223
Query: 170 QELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWL 229
+ L L +LD+S N T+ + + ALE L + SN L+QLPD+I ++ L TL +
Sbjct: 224 GSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKV 283
Query: 230 QRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDN 278
N++T LP TI N+ L S N+L+ +P + + +LR + +N
Sbjct: 284 DDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDEN 332
Score = 95.5 bits (236), Expect = 6e-20
Identities = 64/227 (28%), Positives = 110/227 (48%), Gaps = 4/227 (1%)
Query: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPG 124
L ++ + + LP L L++ + L +P I NL LD+S+N + E P
Sbjct: 51 LYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPEN 110
Query: 125 IGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLS 184
I L + S N I +P + +L +L L + + LP L+KL L+L
Sbjct: 111 IKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLN-DAFLEFLPANFGRLVKLRILELR 169
Query: 185 MNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNM 244
N T+P ++ + LE LD+G+N+ +LP+ ++++QNL LW+ N + LP +I +
Sbjct: 170 ENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKL 229
Query: 245 KNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEG 291
K L L +S N+++ + + + L + N L+ LP S G
Sbjct: 230 KMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQ---QLPDSIG 273
Score = 48.5 bits (114), Expect = 8e-06
Identities = 32/112 (28%), Positives = 58/112 (51%), Gaps = 6/112 (5%)
Query: 170 QELSNLLKLTHLDLSMNDFTTIPLAVLNMP-ALEWLDMGSNKLEQLPDTIERMQNLHTLW 228
+E+ ++L +H L +P V N LE L + +N++E+LP + Q L L
Sbjct: 21 EEIISVLDYSHCSLQQ-----VPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLS 75
Query: 229 LQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPL 280
+ N+++ LP TI+++ NL L +S N +Q+ P ++ L + NP+
Sbjct: 76 IPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPI 127
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 116 bits (291), Expect = 2e-26
Identities = 76/232 (32%), Positives = 120/232 (51%), Gaps = 4/232 (1%)
Query: 58 REDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNT 117
RE+ + L + K LPSS+ +L QL E L+ L +P +G NL+ L LS N+
Sbjct: 98 REENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENS 157
Query: 118 ISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLK 177
++ +P + L +L+ L L +NK++ +P + SL L L NR I + +++ NL K
Sbjct: 158 LTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNR-ITTVEKDIKNLSK 216
Query: 178 LTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCL 237
L+ L + N +P + + L LD+ N+LE LP I + L LQ NE+ L
Sbjct: 217 LSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDL 276
Query: 238 PQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPS 289
P TI N+ +L L L N+L IP + + + L +N +N + +LP S
Sbjct: 277 PDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNIS---TLPES 325
Score = 95.9 bits (237), Expect = 5e-20
Identities = 70/248 (28%), Positives = 123/248 (49%), Gaps = 7/248 (2%)
Query: 48 SLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQN 107
SLT L + + +L + + + +PS + +L+ L L + + + I
Sbjct: 157 SLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSK 216
Query: 108 LIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICD 167
L +L + N I ++P IG L L L +++N+++ +PKE+ NC + L+L N ++ D
Sbjct: 217 LSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHN-ELLD 275
Query: 168 LPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDT-IERMQNLHT 226
LP + NL L+ L L N + IP ++ ALE L++ +N + LP++ + + L++
Sbjct: 276 LPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNS 335
Query: 227 LWLQRNEITCLP-QTISNMKNLGTLVLSNNKLQDIPVCMEEMAN-LRFVNFRDNPLKLKV 284
L L RN P S + +L + +N++ IP + A L +N +DN L
Sbjct: 336 LTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQL---T 392
Query: 285 SLPPSEGT 292
SLP GT
Sbjct: 393 SLPLDFGT 400
Score = 95.9 bits (237), Expect = 5e-20
Identities = 71/220 (32%), Positives = 114/220 (51%), Gaps = 8/220 (3%)
Query: 65 LKIEKEEWKTLPSSLLK-LNQLQEWQLHRTGLLKIPEFIG---RFQNLIVLDLSRNTISE 120
L +E TLP SLL L +L L R P +G +F + L++ N I++
Sbjct: 312 LNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYP--VGGPSQFSTIYSLNMEHNRINK 369
Query: 121 IPPGIGLLTR-LQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLT 179
IP GI + L +L + N++ ++P + S+ +L LA N+ + +P+++S L+ L
Sbjct: 370 IPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQ-LTKIPEDVSGLVSLE 428
Query: 180 HLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQ 239
L LS N +P + N+ L LD+ NKLE LP+ I +++L L L N++T LP+
Sbjct: 429 VLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPR 488
Query: 240 TISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNP 279
I ++ NL L L N L +P + + NL + DNP
Sbjct: 489 GIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNP 528
Score = 93.6 bits (231), Expect = 2e-19
Identities = 82/289 (28%), Positives = 129/289 (44%), Gaps = 56/289 (19%)
Query: 51 KLRE---KVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQN 107
KLRE V R D L + T+ + L++L + + ++P IG N
Sbjct: 180 KLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCN 239
Query: 108 LIV-----------------------LDLSRNTISEIPPGIGLLTRLQELILSYNKIKTV 144
LI LDL N + ++P IG L+ L L L YN++ +
Sbjct: 240 LITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAI 299
Query: 145 PKELSNCASLEKLELAVNRDICDLPQE-LSNLLKLTHLDLSMNDFTTIPLA--------- 194
P+ L+ C++LE+L L N +I LP+ LS+L+KL L L+ N F P+
Sbjct: 300 PRSLAKCSALEELNLE-NNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIY 358
Query: 195 VLNM----------------PALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLP 238
LNM L L+M N+L LP ++ L L N++T +P
Sbjct: 359 SLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIP 418
Query: 239 QTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLP 287
+ +S + +L L+LSNN L+ +P + + LR ++ +N L+ SLP
Sbjct: 419 EDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLE---SLP 464
Score = 92.0 bits (227), Expect = 6e-19
Identities = 81/325 (24%), Positives = 135/325 (41%), Gaps = 55/325 (16%)
Query: 21 RIKKLNEDLKREKEFQHKLVRIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLL 80
RI + +D+K + ++ I E ++ +L ++ + L + + + LP +
Sbjct: 203 RITTVEKDIKNLSKLS--MLSIRENKIK--QLPAEIGELCNLITLDVAHNQLEHLPKEIG 258
Query: 81 KLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNK 140
Q+ L LL +P+ IG +L L L N +S IP + + L+EL L N
Sbjct: 259 NCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNN 318
Query: 141 IKTVPKEL-SNCASLEKLELAVN------------------------------------- 162
I T+P+ L S+ L L LA N
Sbjct: 319 ISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRA 378
Query: 163 ----------RDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLE 212
+ LP + + L+L+ N T IP V + +LE L + +N L+
Sbjct: 379 KVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLK 438
Query: 213 QLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRF 272
+LP + ++ L L L+ N++ LP I+ +K+L LVL+NN+L +P + + NL
Sbjct: 439 KLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTH 498
Query: 273 VNFRDNPLKLKVSLPPSEGTDEEEE 297
+ +N L LP GT E E
Sbjct: 499 LGLGEN---LLTHLPEEIGTLENLE 520
Score = 64.7 bits (156), Expect = 1e-10
Identities = 45/144 (31%), Positives = 72/144 (50%)
Query: 49 LTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNL 108
LTK+ E V+ +L + K LP L L +L+E L L +P I ++L
Sbjct: 414 LTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDL 473
Query: 109 IVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDL 168
L L+ N ++ +P GIG LT L L L N + +P+E+ +LE+L L N ++ L
Sbjct: 474 QKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSL 533
Query: 169 PQELSNLLKLTHLDLSMNDFTTIP 192
P EL+ KL+ + + + +P
Sbjct: 534 PFELALCSKLSIMSIENCPLSHLP 557
Score = 58.5 bits (140), Expect = 8e-09
Identities = 43/157 (27%), Positives = 74/157 (47%), Gaps = 2/157 (1%)
Query: 63 VILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIP 122
V L + + +P + L L+ L L K+P +G + L LDL N + +P
Sbjct: 405 VELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLP 464
Query: 123 PGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLD 182
I L LQ+L+L+ N++ T+P+ + + +L L L N + LP+E+ L L L
Sbjct: 465 NEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENL-LTHLPEEIGTLENLEELY 523
Query: 183 LSMN-DFTTIPLAVLNMPALEWLDMGSNKLEQLPDTI 218
L+ N + ++P + L + + + L LP I
Sbjct: 524 LNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQI 560
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 114 bits (284), Expect = 2e-25
Identities = 68/218 (31%), Positives = 117/218 (53%), Gaps = 1/218 (0%)
Query: 64 ILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPP 123
IL++ + + K LP ++ +L QL+ L ++PE + + L + N ++ IP
Sbjct: 165 ILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPG 224
Query: 124 GIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDL 183
IG L +L L +S N I+ V + +S C +L+ L L+ N + LP+ + +L +T L +
Sbjct: 225 FIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN-SLQQLPETIGSLKNITTLKI 283
Query: 184 SMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN 243
N +P ++ + ++E LD N++E LP +I ++ NL T N + LP I +
Sbjct: 284 DENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGS 343
Query: 244 MKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLK 281
KN+ L L +NKL+ +P M +M L+ +N DN LK
Sbjct: 344 WKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381
Score = 112 bits (281), Expect = 4e-25
Identities = 66/234 (28%), Positives = 124/234 (52%), Gaps = 3/234 (1%)
Query: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPG 124
L + E+ +P L +L+ L+E+ + L IP FIG + L LD+S+N I + G
Sbjct: 189 LDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEG 248
Query: 125 IGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLS 184
I LQ+L+LS N ++ +P+ + + ++ L++ N+ + LP + L+ + LD S
Sbjct: 249 ISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQ-LMYLPDSIGGLISVEELDCS 307
Query: 185 MNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNM 244
N+ +P ++ + L N L+QLP I +N+ L+L N++ LP+ + +M
Sbjct: 308 FNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDM 367
Query: 245 KNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEGTDEEEER 298
+ L + LS+N+L+++P ++ L + DN + K +P + TD E ++
Sbjct: 368 QKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDN--QSKPLIPLQKETDSETQK 419
Score = 105 bits (261), Expect = 7e-23
Identities = 68/227 (29%), Positives = 119/227 (52%), Gaps = 4/227 (1%)
Query: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPG 124
L + + TLP+S+ L L+E + + G+ + PE I + L +++ S N IS++P G
Sbjct: 74 LSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDG 133
Query: 125 IGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLS 184
L L +L L+ ++ +P L+ LEL N+ + LP+ ++ L +L LDL
Sbjct: 134 FSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQ-LKMLPKTMNRLTQLERLDLG 192
Query: 185 MNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNM 244
N+FT +P + + L+ M +N+L +P I ++ L L + +N I + + IS
Sbjct: 193 SNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTC 252
Query: 245 KNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEG 291
+NL L+LS+N LQ +P + + N+ + +N L + LP S G
Sbjct: 253 ENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQL---MYLPDSIG 296
Score = 77.4 bits (189), Expect = 2e-14
Identities = 51/181 (28%), Positives = 86/181 (47%), Gaps = 25/181 (13%)
Query: 103 GRFQNLIVLDLSRNTISEIPPGIGLLTR-LQELILSYNKIKTVPKELSNCASLEKLELAV 161
G + + LD S ++ ++P I + L+EL L N+I+ +PK+L NC SL KL
Sbjct: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLS--- 75
Query: 162 NRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERM 221
L ND TT+P ++ N+ L LD+ N +++ P+ I+
Sbjct: 76 ---------------------LPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNC 114
Query: 222 QNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLK 281
+ L + N I+ LP S + NL L L++ L+ +P + L+ + R+N LK
Sbjct: 115 KVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLK 174
Query: 282 L 282
+
Sbjct: 175 M 175
Score = 61.2 bits (147), Expect = 1e-09
Identities = 41/139 (29%), Positives = 70/139 (50%), Gaps = 1/139 (0%)
Query: 48 SLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQN 107
SL +L E + LKI++ + LP S+ L ++E + +P IG+ N
Sbjct: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTN 323
Query: 108 LIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICD 167
L N + ++PP IG + L L NK++T+P+E+ + L+ + L+ NR + +
Sbjct: 324 LRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNR-LKN 382
Query: 168 LPQELSNLLKLTHLDLSMN 186
LP + L +LT + LS N
Sbjct: 383 LPFSFTKLQQLTAMWLSDN 401
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 114 bits (284), Expect = 2e-25
Identities = 68/218 (31%), Positives = 117/218 (53%), Gaps = 1/218 (0%)
Query: 64 ILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPP 123
IL++ + + K LP ++ +L QL+ L ++PE + + L + N ++ IP
Sbjct: 165 ILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPG 224
Query: 124 GIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDL 183
IG L +L L +S N I+ V + +S C +L+ L L+ N + LP+ + +L +T L +
Sbjct: 225 FIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN-SLQQLPETIGSLKNITTLKI 283
Query: 184 SMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN 243
N +P ++ + ++E LD N++E LP +I ++ NL T N + LP I +
Sbjct: 284 DENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGS 343
Query: 244 MKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLK 281
KN+ L L +NKL+ +P M +M L+ +N DN LK
Sbjct: 344 WKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381
Score = 112 bits (281), Expect = 4e-25
Identities = 66/234 (28%), Positives = 124/234 (52%), Gaps = 3/234 (1%)
Query: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPG 124
L + E+ +P L +L+ L+E+ + L IP FIG + L LD+S+N I + G
Sbjct: 189 LDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEG 248
Query: 125 IGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLS 184
I LQ+L+LS N ++ +P+ + + ++ L++ N+ + LP + L+ + LD S
Sbjct: 249 ISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQ-LMYLPDSIGGLISVEELDCS 307
Query: 185 MNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNM 244
N+ +P ++ + L N L+QLP I +N+ L+L N++ LP+ + +M
Sbjct: 308 FNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDM 367
Query: 245 KNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEGTDEEEER 298
+ L + LS+N+L+++P ++ L + DN + K +P + TD E ++
Sbjct: 368 QKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDN--QSKPLIPLQKETDSETQK 419
Score = 105 bits (261), Expect = 7e-23
Identities = 68/227 (29%), Positives = 119/227 (52%), Gaps = 4/227 (1%)
Query: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPG 124
L + + TLP+S+ L L+E + + G+ + PE I + L +++ S N IS++P G
Sbjct: 74 LSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDG 133
Query: 125 IGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLS 184
L L +L L+ ++ +P L+ LEL N+ + LP+ ++ L +L LDL
Sbjct: 134 FSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQ-LKMLPKTMNRLTQLERLDLG 192
Query: 185 MNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNM 244
N+FT +P + + L+ M +N+L +P I ++ L L + +N I + + IS
Sbjct: 193 SNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTC 252
Query: 245 KNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEG 291
+NL L+LS+N LQ +P + + N+ + +N L + LP S G
Sbjct: 253 ENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQL---MYLPDSIG 296
Score = 77.4 bits (189), Expect = 2e-14
Identities = 51/181 (28%), Positives = 86/181 (47%), Gaps = 25/181 (13%)
Query: 103 GRFQNLIVLDLSRNTISEIPPGIGLLTR-LQELILSYNKIKTVPKELSNCASLEKLELAV 161
G + + LD S ++ ++P I + L+EL L N+I+ +PK+L NC SL KL
Sbjct: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLS--- 75
Query: 162 NRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERM 221
L ND TT+P ++ N+ L LD+ N +++ P+ I+
Sbjct: 76 ---------------------LPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNC 114
Query: 222 QNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLK 281
+ L + N I+ LP S + NL L L++ L+ +P + L+ + R+N LK
Sbjct: 115 KVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLK 174
Query: 282 L 282
+
Sbjct: 175 M 175
Score = 61.2 bits (147), Expect = 1e-09
Identities = 41/139 (29%), Positives = 70/139 (50%), Gaps = 1/139 (0%)
Query: 48 SLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQN 107
SL +L E + LKI++ + LP S+ L ++E + +P IG+ N
Sbjct: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTN 323
Query: 108 LIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICD 167
L N + ++PP IG + L L NK++T+P+E+ + L+ + L+ NR + +
Sbjct: 324 LRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNR-LKN 382
Query: 168 LPQELSNLLKLTHLDLSMN 186
LP + L +LT + LS N
Sbjct: 383 LPFSFTKLQQLTAMWLSDN 401
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 111 bits (278), Expect = 8e-25
Identities = 64/197 (32%), Positives = 105/197 (53%), Gaps = 1/197 (0%)
Query: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPG 124
L ++ + + LP +L L++ L + ++P + F L+ LD+SRN I EIP
Sbjct: 41 LLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPES 100
Query: 125 IGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLS 184
I L+ S N + +P + SL L L + + LP ++ NL L L+L
Sbjct: 101 IKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALN-DVSLQALPGDVGNLANLVTLELR 159
Query: 185 MNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNM 244
N ++P ++ + LE LD+G N LE LPDT+ + NL LWL RN+++ LP + N+
Sbjct: 160 ENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNL 219
Query: 245 KNLGTLVLSNNKLQDIP 261
+ L L +S N+L+++P
Sbjct: 220 RRLVCLDVSENRLEELP 236
Score = 91.7 bits (226), Expect = 8e-19
Identities = 69/240 (28%), Positives = 113/240 (47%), Gaps = 4/240 (1%)
Query: 49 LTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNL 108
L++L + T+ L + + LP + L L +L L +P + L
Sbjct: 117 LSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKL 176
Query: 109 IVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDL 168
LDL N + +P +G L L+EL L N++ +P EL N L L+++ NR + +L
Sbjct: 177 EQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENR-LEEL 235
Query: 169 PQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLW 228
P EL L+ LT L LS N +P + + L L + N+L ++ + I +NL L
Sbjct: 236 PAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELI 295
Query: 229 LQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPP 288
L N + LP+++ + L L + N L+ +P + L ++ RDN L + LPP
Sbjct: 296 LTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAV---LPP 352
Score = 89.4 bits (220), Expect = 4e-18
Identities = 73/241 (30%), Positives = 115/241 (47%), Gaps = 4/241 (1%)
Query: 47 VSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQ 106
VSL L V V L++ + K+LP+SL L +L++ L L +P+ +G
Sbjct: 138 VSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALP 197
Query: 107 NLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDIC 166
NL L L RN +S +PP +G L RL L +S N+++ +P EL L L L+ N +
Sbjct: 198 NLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNL-LR 256
Query: 167 DLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHT 226
LP + L +L+ L + N + A+ + L L + N L LP ++ ++ L
Sbjct: 257 RLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTN 316
Query: 227 LWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSL 286
L + RN + LP I L L L +N+L +P + L ++ N L+ SL
Sbjct: 317 LNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQ---SL 373
Query: 287 P 287
P
Sbjct: 374 P 374
Score = 87.8 bits (216), Expect = 1e-17
Identities = 55/173 (31%), Positives = 92/173 (53%), Gaps = 2/173 (1%)
Query: 111 LDLSRNTISEIPPGIGLLTR-LQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLP 169
+D ++ +P I +R L+EL+L N+++ +PK +L KL L+ N +I LP
Sbjct: 17 VDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDN-EIQRLP 75
Query: 170 QELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWL 229
E++N ++L LD+S ND IP ++ ALE D N L +LPD ++++L L L
Sbjct: 76 PEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLAL 135
Query: 230 QRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKL 282
+ LP + N+ NL TL L N L+ +P + + L ++ N L++
Sbjct: 136 NDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEV 188
Score = 87.4 bits (215), Expect = 2e-17
Identities = 71/232 (30%), Positives = 110/232 (47%), Gaps = 15/232 (6%)
Query: 73 KTLPSSLLKLNQ-LQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRL 131
+ +P + + ++ L+E L L ++P+ R NL L LS N I +PP + +L
Sbjct: 25 QAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQL 84
Query: 132 QELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTI 191
EL +S N I +P+ + C +LE + + N + LP + L L HL L+ +
Sbjct: 85 VELDVSRNDIPEIPESIKFCKALEIADFSGN-PLSRLPDGFTQLRSLAHLALNDVSLQAL 143
Query: 192 PLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLV 251
P V N+ L L++ N L+ LP ++ + L L L N++ LP T+ + NL L
Sbjct: 144 PGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELW 203
Query: 252 LSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEGTDEEEERELFGL 303
L N+L +P E+ NLR + V L SE EE EL GL
Sbjct: 204 LDRNQLSALP---PELGNLRRL----------VCLDVSENRLEELPAELGGL 242
Score = 87.4 bits (215), Expect = 2e-17
Identities = 73/250 (29%), Positives = 112/250 (44%), Gaps = 27/250 (10%)
Query: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPG 124
L + E + LP + QL E + R + +IPE I + L + D S N +S +P G
Sbjct: 64 LGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDG 123
Query: 125 -----------------------IGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAV 161
+G L L L L N +K++P LS LE+L+L
Sbjct: 124 FTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGG 183
Query: 162 NRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERM 221
N D+ LP L L L L L N + +P + N+ L LD+ N+LE+LP + +
Sbjct: 184 N-DLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGL 242
Query: 222 QNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLK 281
L L L +N + LP I +K L L + N+L ++ + + NL + +N
Sbjct: 243 VLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTEN--- 299
Query: 282 LKVSLPPSEG 291
L ++LP S G
Sbjct: 300 LLMALPRSLG 309
Score = 86.3 bits (212), Expect = 4e-17
Identities = 64/217 (29%), Positives = 104/217 (47%), Gaps = 25/217 (11%)
Query: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPG 124
L + + + LP +L L L+E L R L +P +G + L+ LD+S N + E+P
Sbjct: 179 LDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAE 238
Query: 125 IGLLTRLQELILSYNKIKTVP------KELS-----------------NCASLEKLELAV 161
+G L L +L+LS N ++ +P K+LS +C +L +L L
Sbjct: 239 LGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTE 298
Query: 162 NRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERM 221
N + LP+ L L KLT+L++ N +P + AL L + N+L LP +
Sbjct: 299 NL-LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHT 357
Query: 222 QNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQ 258
LH L + N + LP ++++ NL L L+ N+ Q
Sbjct: 358 TELHVLDVAGNRLQSLPFALTHL-NLKALWLAENQAQ 393
Score = 81.3 bits (199), Expect = 1e-15
Identities = 55/195 (28%), Positives = 94/195 (48%), Gaps = 2/195 (1%)
Query: 39 LVRIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKI 98
L +W +R L+ L ++ V L + + + LP+ L L L + L + L ++
Sbjct: 199 LRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRL 258
Query: 99 PEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLE 158
P+ IG+ + L +L + +N + E+ IG L ELIL+ N + +P+ L L L
Sbjct: 259 PDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLN 318
Query: 159 LAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTI 218
+ N + LP E+ + L+ L L N +P + + L LD+ N+L+ LP +
Sbjct: 319 VDRNH-LEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFAL 377
Query: 219 ERMQNLHTLWLQRNE 233
+ NL LWL N+
Sbjct: 378 THL-NLKALWLAENQ 391
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 111 bits (278), Expect = 8e-25
Identities = 64/197 (32%), Positives = 105/197 (53%), Gaps = 1/197 (0%)
Query: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPG 124
L ++ + + LP +L L++ L + ++P + F L+ LD+SRN I EIP
Sbjct: 41 LLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPES 100
Query: 125 IGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLS 184
I L+ S N + +P + SL L L + + LP ++ NL L L+L
Sbjct: 101 IKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALN-DVSLQALPGDVGNLANLVTLELR 159
Query: 185 MNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNM 244
N ++P ++ + LE LD+G N LE LPDT+ + NL LWL RN+++ LP + N+
Sbjct: 160 ENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNL 219
Query: 245 KNLGTLVLSNNKLQDIP 261
+ L L +S N+L+++P
Sbjct: 220 RRLVCLDVSENRLEELP 236
Score = 91.7 bits (226), Expect = 8e-19
Identities = 69/240 (28%), Positives = 113/240 (47%), Gaps = 4/240 (1%)
Query: 49 LTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNL 108
L++L + T+ L + + LP + L L +L L +P + L
Sbjct: 117 LSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKL 176
Query: 109 IVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDL 168
LDL N + +P +G L L+EL L N++ +P EL N L L+++ NR + +L
Sbjct: 177 EQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENR-LEEL 235
Query: 169 PQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLW 228
P EL L+ LT L LS N +P + + L L + N+L ++ + I +NL L
Sbjct: 236 PAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELI 295
Query: 229 LQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPP 288
L N + LP+++ + L L + N L+ +P + L ++ RDN L + LPP
Sbjct: 296 LTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAV---LPP 352
Score = 89.4 bits (220), Expect = 4e-18
Identities = 73/241 (30%), Positives = 115/241 (47%), Gaps = 4/241 (1%)
Query: 47 VSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQ 106
VSL L V V L++ + K+LP+SL L +L++ L L +P+ +G
Sbjct: 138 VSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALP 197
Query: 107 NLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDIC 166
NL L L RN +S +PP +G L RL L +S N+++ +P EL L L L+ N +
Sbjct: 198 NLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNL-LR 256
Query: 167 DLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHT 226
LP + L +L+ L + N + A+ + L L + N L LP ++ ++ L
Sbjct: 257 RLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTN 316
Query: 227 LWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSL 286
L + RN + LP I L L L +N+L +P + L ++ N L+ SL
Sbjct: 317 LNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQ---SL 373
Query: 287 P 287
P
Sbjct: 374 P 374
Score = 87.8 bits (216), Expect = 1e-17
Identities = 55/173 (31%), Positives = 92/173 (53%), Gaps = 2/173 (1%)
Query: 111 LDLSRNTISEIPPGIGLLTR-LQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLP 169
+D ++ +P I +R L+EL+L N+++ +PK +L KL L+ N +I LP
Sbjct: 17 VDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDN-EIQRLP 75
Query: 170 QELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWL 229
E++N ++L LD+S ND IP ++ ALE D N L +LPD ++++L L L
Sbjct: 76 PEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLAL 135
Query: 230 QRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKL 282
+ LP + N+ NL TL L N L+ +P + + L ++ N L++
Sbjct: 136 NDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEV 188
Score = 87.4 bits (215), Expect = 2e-17
Identities = 71/232 (30%), Positives = 110/232 (47%), Gaps = 15/232 (6%)
Query: 73 KTLPSSLLKLNQ-LQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRL 131
+ +P + + ++ L+E L L ++P+ R NL L LS N I +PP + +L
Sbjct: 25 QAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQL 84
Query: 132 QELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTI 191
EL +S N I +P+ + C +LE + + N + LP + L L HL L+ +
Sbjct: 85 VELDVSRNDIPEIPESIKFCKALEIADFSGN-PLSRLPDGFTQLRSLAHLALNDVSLQAL 143
Query: 192 PLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLV 251
P V N+ L L++ N L+ LP ++ + L L L N++ LP T+ + NL L
Sbjct: 144 PGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELW 203
Query: 252 LSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEGTDEEEERELFGL 303
L N+L +P E+ NLR + V L SE EE EL GL
Sbjct: 204 LDRNQLSALP---PELGNLRRL----------VCLDVSENRLEELPAELGGL 242
Score = 87.4 bits (215), Expect = 2e-17
Identities = 73/250 (29%), Positives = 112/250 (44%), Gaps = 27/250 (10%)
Query: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPG 124
L + E + LP + QL E + R + +IPE I + L + D S N +S +P G
Sbjct: 64 LGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDG 123
Query: 125 -----------------------IGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAV 161
+G L L L L N +K++P LS LE+L+L
Sbjct: 124 FTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGG 183
Query: 162 NRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERM 221
N D+ LP L L L L L N + +P + N+ L LD+ N+LE+LP + +
Sbjct: 184 N-DLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGL 242
Query: 222 QNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLK 281
L L L +N + LP I +K L L + N+L ++ + + NL + +N
Sbjct: 243 VLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTEN--- 299
Query: 282 LKVSLPPSEG 291
L ++LP S G
Sbjct: 300 LLMALPRSLG 309
Score = 86.3 bits (212), Expect = 4e-17
Identities = 64/217 (29%), Positives = 104/217 (47%), Gaps = 25/217 (11%)
Query: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPG 124
L + + + LP +L L L+E L R L +P +G + L+ LD+S N + E+P
Sbjct: 179 LDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAE 238
Query: 125 IGLLTRLQELILSYNKIKTVP------KELS-----------------NCASLEKLELAV 161
+G L L +L+LS N ++ +P K+LS +C +L +L L
Sbjct: 239 LGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTE 298
Query: 162 NRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERM 221
N + LP+ L L KLT+L++ N +P + AL L + N+L LP +
Sbjct: 299 NL-LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHT 357
Query: 222 QNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQ 258
LH L + N + LP ++++ NL L L+ N+ Q
Sbjct: 358 TELHVLDVAGNRLQSLPFALTHL-NLKALWLAENQAQ 393
Score = 81.3 bits (199), Expect = 1e-15
Identities = 55/195 (28%), Positives = 94/195 (48%), Gaps = 2/195 (1%)
Query: 39 LVRIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKI 98
L +W +R L+ L ++ V L + + + LP+ L L L + L + L ++
Sbjct: 199 LRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRL 258
Query: 99 PEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLE 158
P+ IG+ + L +L + +N + E+ IG L ELIL+ N + +P+ L L L
Sbjct: 259 PDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLN 318
Query: 159 LAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTI 218
+ N + LP E+ + L+ L L N +P + + L LD+ N+L+ LP +
Sbjct: 319 VDRNH-LEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFAL 377
Query: 219 ERMQNLHTLWLQRNE 233
+ NL LWL N+
Sbjct: 378 THL-NLKALWLAENQ 391
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 111 bits (278), Expect = 8e-25
Identities = 69/209 (33%), Positives = 114/209 (54%), Gaps = 10/209 (4%)
Query: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPG 124
L ++ + + LP +L +L++ L + ++P I F L+ LD+SRN I EIP
Sbjct: 41 LLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPES 100
Query: 125 IGLLTRLQELILSYNKIKTVPK---ELSNCASLEKLELAVNRDICDLPQELSNLLKLTHL 181
I LQ S N + +P+ EL N L ++++ LP+ + NL L L
Sbjct: 101 ISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQ----SLPENIGNLYNLASL 156
Query: 182 DLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTI 241
+L N T +P ++ + LE LD+G+N++ LP++I + +L LWL N+++ LPQ I
Sbjct: 157 ELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEI 216
Query: 242 SNMKNLGTLVLSNNKLQDIPVCMEEMANL 270
N+KNL L +S N+L+ +P EE++ L
Sbjct: 217 GNLKNLLCLDVSENRLERLP---EEISGL 242
Score = 111 bits (277), Expect = 1e-24
Identities = 72/232 (31%), Positives = 116/232 (50%), Gaps = 1/232 (0%)
Query: 49 LTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNL 108
LT+L E L + ++LP ++ L L +L L +P+ + + + L
Sbjct: 117 LTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRL 176
Query: 109 IVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDL 168
LDL N I +P IG L L++L L N++ +P+E+ N +L L+++ NR + L
Sbjct: 177 EELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENR-LERL 235
Query: 169 PQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLW 228
P+E+S L LT L +S N TIP + + L L + N+L QLP+ + ++L L
Sbjct: 236 PEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELV 295
Query: 229 LQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPL 280
L N++ LP++I +K L L NKL +P + +L RDN L
Sbjct: 296 LTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRL 347
Score = 107 bits (267), Expect = 1e-23
Identities = 71/217 (32%), Positives = 114/217 (52%), Gaps = 4/217 (1%)
Query: 75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQEL 134
LP S +L L ++ L +PE IG NL L+L N ++ +P + L RL+EL
Sbjct: 120 LPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEEL 179
Query: 135 ILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLA 194
L N+I +P+ + L+ L L N+ + +LPQE+ NL L LD+S N +P
Sbjct: 180 DLGNNEIYNLPESIGALLHLKDLWLDGNQ-LSELPQEIGNLKNLLCLDVSENRLERLPEE 238
Query: 195 VLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSN 254
+ + +L L + N LE +PD I +++ L L + +N +T LP+ + ++L LVL+
Sbjct: 239 ISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTE 298
Query: 255 NKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEG 291
N+L +P + ++ L +N N L VSLP G
Sbjct: 299 NQLLTLPKSIGKLKKLSNLNADRNKL---VSLPKEIG 332
Score = 100 bits (250), Expect = 1e-21
Identities = 68/229 (29%), Positives = 112/229 (48%), Gaps = 4/229 (1%)
Query: 63 VILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIP 122
V L + + E +P S+ LQ L ++PE QNL L ++ ++ +P
Sbjct: 85 VELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLP 144
Query: 123 PGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLD 182
IG L L L L N + +P L+ LE+L+L N +I +LP+ + LL L L
Sbjct: 145 ENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLG-NNEIYNLPESIGALLHLKDLW 203
Query: 183 LSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTIS 242
L N + +P + N+ L LD+ N+LE+LP+ I + +L L + +N + +P I
Sbjct: 204 LDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIG 263
Query: 243 NMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEG 291
+K L L + N+L +P + E +L + +N L ++LP S G
Sbjct: 264 KLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQL---LTLPKSIG 309
Score = 99.0 bits (245), Expect = 5e-21
Identities = 70/234 (29%), Positives = 116/234 (49%), Gaps = 1/234 (0%)
Query: 47 VSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQ 106
+SL L E + L++ + LP SL +L +L+E L + +PE IG
Sbjct: 138 ISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALL 197
Query: 107 NLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDIC 166
+L L L N +SE+P IG L L L +S N+++ +P+E+S SL L ++ N +
Sbjct: 198 HLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNL-LE 256
Query: 167 DLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHT 226
+P + L KL+ L + N T +P AV +L L + N+L LP +I +++ L
Sbjct: 257 TIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSN 316
Query: 227 LWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPL 280
L RN++ LP+ I +L + +N+L IP + + L ++ N L
Sbjct: 317 LNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRL 370
Score = 95.9 bits (237), Expect = 5e-20
Identities = 63/216 (29%), Positives = 108/216 (50%), Gaps = 1/216 (0%)
Query: 49 LTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNL 108
LT L + +T+ L + E LP S+ L L++ L L ++P+ IG +NL
Sbjct: 163 LTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNL 222
Query: 109 IVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDL 168
+ LD+S N + +P I LT L +L++S N ++T+P + L L++ NR + L
Sbjct: 223 LCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNR-LTQL 281
Query: 169 PQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLW 228
P+ + LT L L+ N T+P ++ + L L+ NKL LP I +L
Sbjct: 282 PEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFC 341
Query: 229 LQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCM 264
++ N +T +P +S L L ++ N+L +P+ +
Sbjct: 342 VRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSL 377
Score = 85.5 bits (210), Expect = 6e-17
Identities = 51/161 (31%), Positives = 88/161 (54%), Gaps = 4/161 (2%)
Query: 131 LQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTT 190
L+EL+L N+++ +P++ L KL L+ N +I LP E++N ++L LD+S N+
Sbjct: 38 LEELLLDANQLRELPEQFFQLVKLRKLGLSDN-EIQRLPPEIANFMQLVELDVSRNEIPE 96
Query: 191 IPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTL 250
IP ++ AL+ D N L +LP++ +QNL L + + LP+ I N+ NL +L
Sbjct: 97 IPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASL 156
Query: 251 VLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEG 291
L N L +P + ++ L ++ +N + +LP S G
Sbjct: 157 ELRENLLTYLPDSLTQLRRLEELDLGNNEI---YNLPESIG 194
Score = 84.7 bits (208), Expect = 1e-16
Identities = 54/178 (30%), Positives = 101/178 (56%), Gaps = 2/178 (1%)
Query: 95 LLKIPEFIGRF-QNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCAS 153
L+ +PE I R+ ++L L L N + E+P L +L++L LS N+I+ +P E++N
Sbjct: 24 LVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQ 83
Query: 154 LEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQ 213
L +L+++ N +I ++P+ +S L D S N T +P + + L L + L+
Sbjct: 84 LVELDVSRN-EIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQS 142
Query: 214 LPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLR 271
LP+ I + NL +L L+ N +T LP +++ ++ L L L NN++ ++P + + +L+
Sbjct: 143 LPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLK 200
Score = 84.3 bits (207), Expect = 1e-16
Identities = 51/192 (26%), Positives = 95/192 (49%), Gaps = 2/192 (1%)
Query: 42 IWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEF 101
+W + L++L +++ + L + + + LP + L L + + + L IP+
Sbjct: 202 LWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDG 261
Query: 102 IGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAV 161
IG+ + L +L + +N ++++P +G L EL+L+ N++ T+PK + L L
Sbjct: 262 IGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADR 321
Query: 162 NRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERM 221
N+ + LP+E+ LT + N T IP V L LD+ N+L LP ++ +
Sbjct: 322 NK-LVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTAL 380
Query: 222 QNLHTLWLQRNE 233
+ L LWL N+
Sbjct: 381 K-LKALWLSDNQ 391
Score = 67.8 bits (164), Expect = 1e-11
Identities = 43/138 (31%), Positives = 76/138 (55%), Gaps = 2/138 (1%)
Query: 144 VPKELSNCA-SLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALE 202
VP+E+ A SLE+L L N+ + +LP++ L+KL L LS N+ +P + N L
Sbjct: 27 VPEEIYRYARSLEELLLDANQ-LRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLV 85
Query: 203 WLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPV 262
LD+ N++ ++P++I + L N +T LP++ ++NL L +++ LQ +P
Sbjct: 86 ELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPE 145
Query: 263 CMEEMANLRFVNFRDNPL 280
+ + NL + R+N L
Sbjct: 146 NIGNLYNLASLELRENLL 163
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 106 bits (265), Expect = 3e-23
Identities = 74/240 (30%), Positives = 116/240 (48%), Gaps = 28/240 (11%)
Query: 82 LNQLQEWQLHRTGLLKIPEFIGR-FQNLIVLDLSRNTISEIPPGIG-------------- 126
L ++ L GL ++PE +G +L VL L RN + +PP +
Sbjct: 62 LGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHN 121
Query: 127 -----------LLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNL 175
L L++L LS+N++ +P +L A LE+L+++ NR + LP LS L
Sbjct: 122 RLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNR-LAHLPDSLSCL 180
Query: 176 LKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEIT 235
+L LD+ N T P +L + ALE LD+ SN+L LP+ I ++ L LWL E+
Sbjct: 181 SRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELG 240
Query: 236 CLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPL-KLKVSLPPSEGTDE 294
LP + +L +L+L NN LQ +P + L+ +N N + +L P G +E
Sbjct: 241 TLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEE 300
Score = 99.0 bits (245), Expect = 5e-21
Identities = 69/206 (33%), Positives = 102/206 (49%), Gaps = 1/206 (0%)
Query: 75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQEL 134
LP SL L++L+ + L P + + L LD+S N + +P I L L+ L
Sbjct: 173 LPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKIL 232
Query: 135 ILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLA 194
LS ++ T+P ASLE L L N + LP + S L +L L+LS N F P A
Sbjct: 233 WLSGAELGTLPAGFCELASLESLMLD-NNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAA 291
Query: 195 VLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSN 254
+L + LE L + N+L +P I + L TLWL N I LP +I + L LVL
Sbjct: 292 LLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQG 351
Query: 255 NKLQDIPVCMEEMANLRFVNFRDNPL 280
N++ +P +++ + +DNPL
Sbjct: 352 NQIAVLPDHFGQLSRVGLWKIKDNPL 377
Score = 84.7 bits (208), Expect = 1e-16
Identities = 60/203 (29%), Positives = 96/203 (47%), Gaps = 3/203 (1%)
Query: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPG 124
L ++ + P LL+L L+E + L +PE I + L +L LS + +P G
Sbjct: 186 LDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAG 245
Query: 125 IGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLS 184
L L+ L+L N ++ +P + S L+ L L+ N + P L L L L LS
Sbjct: 246 FCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNL-FEEFPAALLPLAGLEELYLS 304
Query: 185 MNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNM 244
N T++P + + L L + +N++ LPD+I + L L LQ N+I LP +
Sbjct: 305 RNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQL 364
Query: 245 KNLGTLVLSNNKLQDIP--VCME 265
+G + +N L P VCM+
Sbjct: 365 SRVGLWKIKDNPLIQPPYEVCMK 387
Score = 62.8 bits (151), Expect = 4e-10
Identities = 56/178 (31%), Positives = 80/178 (44%), Gaps = 7/178 (3%)
Query: 21 RIKKLNEDLKREKEFQHKL---VRIWEERVSLTKLR---EKVTREDGRVILKIEKEEWKT 74
R++ L+ D + F +L V + E VS +LR E ++ IL + E T
Sbjct: 182 RLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGT 241
Query: 75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQEL 134
LP+ +L L+ L GL +P Q L +L+LS N E P + L L+EL
Sbjct: 242 LPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEEL 301
Query: 135 ILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIP 192
LS N++ +VP +S L L L NR I LP + L L L L N +P
Sbjct: 302 YLSRNQLTSVPSLISGLGRLLTLWLDNNR-IRYLPDSIVELTGLEELVLQGNQIAVLP 358
Score = 36.2 bits (82), Expect = 0.042
Identities = 25/87 (28%), Positives = 48/87 (55%), Gaps = 3/87 (3%)
Query: 197 NMPALEWLDMGSNKLEQLPDTI-ERMQNLHTLWLQRNEITCLPQTISNM-KNLGTLVLSN 254
N+ +E L++G+N LE++P+ + + +L L L+RN LP ++ + +L L +S+
Sbjct: 61 NLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSH 120
Query: 255 NKLQDIPV-CMEEMANLRFVNFRDNPL 280
N+L + + + LR +N N L
Sbjct: 121 NRLTALGAEVVSALRELRKLNLSHNQL 147
Score = 28.9 bits (63), Expect = 6.8
Identities = 22/109 (20%), Positives = 48/109 (44%), Gaps = 6/109 (5%)
Query: 20 KRIKKLNEDLKREKEFQHKLV------RIWEERVSLTKLREKVTREDGRVILKIEKEEWK 73
+R+K LN +EF L+ ++ R LT + ++ + L ++ +
Sbjct: 273 QRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIR 332
Query: 74 TLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIP 122
LP S+++L L+E L + +P+ G+ + + + N + + P
Sbjct: 333 YLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPP 381
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 106 bits (265), Expect = 3e-23
Identities = 86/306 (28%), Positives = 147/306 (48%), Gaps = 37/306 (12%)
Query: 24 KLNEDLKRE--KEFQHKLVRIWEERVSLTKL-----REKVTREDGRV-----ILKIEKEE 71
++N D+ E + W E+ LTKL + + +D R+ +L I +
Sbjct: 57 RINVDIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQ 116
Query: 72 WKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRL 131
+LPS++ +L LQ+ + L +PE I +NL L L N ++ I G L+ L
Sbjct: 117 LTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNL 176
Query: 132 QELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTI 191
++L LS N + TVP S+ +SL +L L+ N ++ LP E++ + +L HLD + N TI
Sbjct: 177 EDLDLSNNHLTTVPASFSSLSSLVRLNLSSN-ELKSLPAEINRMKRLKHLDCNSNLLETI 235
Query: 192 PLAVLNMPALEWLDMGSNKLEQLP-----------------------DTIERMQNLHTLW 228
P + M +LE L + NKL LP + ++ + ++ L
Sbjct: 236 PPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLD 295
Query: 229 LQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPP 288
L+ N++ +P I +++L L LSNN + +P + + +L+F+ NPL+
Sbjct: 296 LRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREII 354
Query: 289 SEGTDE 294
S+GT E
Sbjct: 355 SKGTQE 360
Score = 82.0 bits (201), Expect = 7e-16
Identities = 61/194 (31%), Positives = 96/194 (49%), Gaps = 10/194 (5%)
Query: 94 GLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCAS 153
GLLK G+ L+LS +SE+P + + + N +
Sbjct: 30 GLLKAARKSGQ------LNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTD 83
Query: 154 LEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQ 213
L KL ++ N+ + L +L L LT LD+ N T++P A+ + L+ L++ NKL+
Sbjct: 84 LTKLIISNNK-LQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKI 142
Query: 214 LPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFV 273
LP+ I ++NL L+LQ NE+TC+ + + NL L LSNN L +P +++L +
Sbjct: 143 LPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRL 202
Query: 274 NFRDNPLKLKVSLP 287
N N LK SLP
Sbjct: 203 NLSSNELK---SLP 213
Score = 73.9 bits (180), Expect = 2e-13
Identities = 63/223 (28%), Positives = 108/223 (48%), Gaps = 25/223 (11%)
Query: 49 LTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNL 108
L LR K+ ++DG + E TLPS +H LKI ++ + L
Sbjct: 362 LKYLRSKI-KDDGPSQSESATETAMTLPSE-------SRVNIHAIITLKILDYSDKQATL 413
Query: 109 IV--------------LDLSRNTISEIPPG-IGLLTRLQELILSYNKIKTVPKELSNCAS 153
I ++ S+N + EIP + L + ++ LS+NK+ + EL
Sbjct: 414 IPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQK 473
Query: 154 LEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQ 213
L L+L N + LP+E+ +L++L ++LS N F +P + + LE + + +N++
Sbjct: 474 LTFLDLR-NNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGS 532
Query: 214 L-PDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNN 255
+ P ++ M+NL TL LQ N++ +P + N NL TL+L N
Sbjct: 533 VDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
Score = 65.1 bits (157), Expect = 9e-11
Identities = 47/178 (26%), Positives = 91/178 (51%), Gaps = 9/178 (5%)
Query: 119 SEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVN---RDICDLPQELSNL 175
SE I + L+ L S + +P E+ + + ++N +C++P+ + L
Sbjct: 389 SESRVNIHAIITLKILDYSDKQATLIPDEVFDAVK-SNIVTSINFSKNQLCEIPKRMVEL 447
Query: 176 LKL-THLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEI 234
++ + +DLS N + I L + + L +LD+ +N L LP+ +E + L T+ L N
Sbjct: 448 KEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRF 507
Query: 235 TCLPQTISNMKNLGTLVLSNNKLQDI-PVCMEEMANLRFVNFRDNPLKLKVSLPPSEG 291
LP+ + + L T+++SNN++ + P M+ M NL ++ ++N L + +PP G
Sbjct: 508 KMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDL---LQIPPELG 562
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 106 bits (264), Expect = 3e-23
Identities = 76/265 (28%), Positives = 135/265 (50%), Gaps = 9/265 (3%)
Query: 21 RIKKLNEDLKREKEFQHKLVRIWEERVS------LTKLREKVTREDGRVILKIEKEEWKT 74
+IK+L + + HK+ E R+ L + EK++ L + +
Sbjct: 350 KIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTE 409
Query: 75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQEL 134
LP + KLN L++ ++R ++KI + I N+ L+ S N I+++P I ++ ++
Sbjct: 410 LPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKI 469
Query: 135 ILSYNKIKTVPKELSNCASLEKLELAVNRD-ICDLPQELSNLLKLTHLDLSMNDFTTIPL 193
LSYNKI P L CA L+VN + I ++P ++S +L HL+LS N
Sbjct: 470 ELSYNKIMYFP--LGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSE 527
Query: 194 AVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLS 253
++ L++LD+G N+++++P +I M +LH L L N+ P+ + ++NL L LS
Sbjct: 528 HFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLS 587
Query: 254 NNKLQDIPVCMEEMANLRFVNFRDN 278
N+LQ I + + ++ +NF N
Sbjct: 588 ENQLQKISSDICNLKGIQKLNFSSN 612
Score = 103 bits (258), Expect = 2e-22
Identities = 75/246 (30%), Positives = 116/246 (47%), Gaps = 25/246 (10%)
Query: 60 DGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTIS 119
D L + +P + QL +L LL E NL LDL +N I
Sbjct: 487 DSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIK 546
Query: 120 EIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNR------DICDL----- 168
+IP I + L LIL NK +T P+EL +L+ L+L+ N+ DIC+L
Sbjct: 547 KIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQK 606
Query: 169 -----------PQELSNLLKLTHLDLSM---NDFTTIPLAVLNMPALEWLDMGSNKLEQL 214
P EL L L L++S T +P + NM L+ LD+ +N + ++
Sbjct: 607 LNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREI 666
Query: 215 PDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVN 274
P I ++NL +L N+I+ LP ++ ++ +L L LS N L +P + + +L+ +N
Sbjct: 667 PRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEIN 726
Query: 275 FRDNPL 280
F DNPL
Sbjct: 727 FDDNPL 732
Score = 101 bits (252), Expect = 8e-22
Identities = 76/239 (31%), Positives = 115/239 (48%), Gaps = 10/239 (4%)
Query: 52 LREKVTREDGRVILKIEKEEWKTLPSSLLKLNQ---------LQEWQLHRTGLLKIPEFI 102
L K +E + ILKI+ ++ L + +K Q L+ L GL +P I
Sbjct: 148 LEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEI 207
Query: 103 GRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVN 162
NL +L++S N IS IP I L +++L N I+ P +L +LE L L N
Sbjct: 208 QLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKN 267
Query: 163 RDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQ 222
+ + +P L +L L L+L N TT P A+ +P L LD+ N + LP I ++
Sbjct: 268 K-LRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELK 326
Query: 223 NLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLK 281
NL TL + N++T L I + + L L++NKL+ I +E LR + N LK
Sbjct: 327 NLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLK 385
Score = 92.8 bits (229), Expect = 4e-19
Identities = 63/220 (28%), Positives = 108/220 (49%), Gaps = 2/220 (0%)
Query: 64 ILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPP 123
IL + +P + +L +++ + + P + NL +L L +N + IP
Sbjct: 215 ILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPD 274
Query: 124 GIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDL 183
+ L L+ L L YN++ T PK L L L+L N I LP+E+ L L L +
Sbjct: 275 TLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNL-ISSLPKEIRELKNLETLLM 333
Query: 184 SMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN 243
N T + + + + ++ L + NKLE + IE + L L L +N + +P+ IS
Sbjct: 334 DHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISC 393
Query: 244 MKNLGTLVLSNNKLQDIPVCMEEMANLRFVNF-RDNPLKL 282
L L LS+NKL ++P + ++ NLR ++ R+N +K+
Sbjct: 394 CAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKI 433
Score = 90.9 bits (224), Expect = 1e-18
Identities = 74/260 (28%), Positives = 128/260 (49%), Gaps = 5/260 (1%)
Query: 64 ILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPP 123
IL ++K K +P + L+ L L ++P++I + NL L ++RN + +I
Sbjct: 376 ILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITD 435
Query: 124 GIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDL 183
I L + L S N I VP E+ NC + K+EL+ N+ I P L L L +L +
Sbjct: 436 CISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNK-IMYFPLGLCALDSLYYLSV 494
Query: 184 SMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN 243
+ N + IP+ + L L++ NKL + + NL L L +N+I +P +ISN
Sbjct: 495 NGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISN 554
Query: 244 MKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPL-KLKVSLPPSEGTDEEEERELFG 302
M +L L+L NK + P + + NL+ ++ +N L K+ + +G ++
Sbjct: 555 MISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGI---QKLNFSS 611
Query: 303 LQFMHTYIQESRRRADHQVN 322
QF+H I+ + ++ Q+N
Sbjct: 612 NQFIHFPIELCQLQSLEQLN 631
Score = 85.9 bits (211), Expect = 5e-17
Identities = 63/216 (29%), Positives = 104/216 (48%), Gaps = 6/216 (2%)
Query: 73 KTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQ 132
+ PS L L L+ L + L IP+ + + L VL+L N ++ P + L +L
Sbjct: 247 ENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLI 306
Query: 133 ELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIP 192
L L+ N I ++PKE+ +LE L + N+ + L E+ LLK+ L L+ N I
Sbjct: 307 SLDLTGNLISSLPKEIRELKNLETLLMDHNK-LTFLAVEIFQLLKIKELQLADNKLEVIS 365
Query: 193 LAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVL 252
+ N L L + N L+ +P+ I L L L N++T LP+ I + NL L +
Sbjct: 366 HKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHV 425
Query: 253 SNNKLQDIPVCMEEMANLRFVNFRDN-----PLKLK 283
+ N + I C+ + N+ + F N P+++K
Sbjct: 426 NRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIK 461
>gi|157743290 leucine rich repeat containing 30 [Homo sapiens]
Length = 301
Score = 105 bits (261), Expect = 7e-23
Identities = 68/240 (28%), Positives = 126/240 (52%), Gaps = 3/240 (1%)
Query: 75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQEL 134
+P L L+++Q+ L L +P +G+ ++VL+L N + +P + LL L+ L
Sbjct: 63 IPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVL 122
Query: 135 ILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLA 194
++ N + VP ELS C LE L L+ N + LP ++L +L L+LS N F IP+
Sbjct: 123 FVNMNCLTEVPAELSLCRKLEVLSLSHNC-LSQLPACFADLSRLRKLNLSNNFFAHIPMC 181
Query: 195 VLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSN 254
V ++ L +L +GSN+LE + ++I+ + +L + N I P+++ + +L L L+N
Sbjct: 182 VFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNN 241
Query: 255 NKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEGTDEEEERELFGLQFMHTYIQESR 314
N +Q +P + + R V NP+ + + + + E GL+ + Y+++ +
Sbjct: 242 NDIQTLPSELHLLC--RLVRIAWNPMDKGLHISHNPLSKPLPELVEGGLEMLFGYLKDKK 299
Score = 64.3 bits (155), Expect = 1e-10
Identities = 36/118 (30%), Positives = 63/118 (53%)
Query: 161 VNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIER 220
V R + D+P L L ++ L+LS N +P V + + L++ N+L+ LP +
Sbjct: 56 VTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSL 115
Query: 221 MQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDN 278
+Q L L++ N +T +P +S + L L LS+N L +P C +++ LR +N +N
Sbjct: 116 LQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNN 173
Score = 53.9 bits (128), Expect = 2e-07
Identities = 40/162 (24%), Positives = 80/162 (49%), Gaps = 1/162 (0%)
Query: 63 VILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIP 122
V+L + K+LP + L L+ ++ L ++P + + L VL LS N +S++P
Sbjct: 97 VVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLP 156
Query: 123 PGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLD 182
L+RL++L LS N +P + + L L + NR + ++ + + +L L
Sbjct: 157 ACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNR-LENIAESIQHLASLQIFI 215
Query: 183 LSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNL 224
N+ + P ++ + +LE L++ +N ++ LP + + L
Sbjct: 216 AEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRL 257
>gi|63003903 leucine rich repeat containing 10 [Homo sapiens]
Length = 277
Score = 101 bits (251), Expect = 1e-21
Identities = 62/187 (33%), Positives = 97/187 (51%), Gaps = 2/187 (1%)
Query: 95 LLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASL 154
L + P + F+ L+ L LS N ++ +PP +G L LQ L L +N K +P+ + L
Sbjct: 41 LRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQL 100
Query: 155 EKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQL 214
L L N+ +CDLP ELS L L L + N T +P V + L+ L GSN L L
Sbjct: 101 CILYLGNNK-LCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLL 159
Query: 215 PDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVN 274
P + R+Q L T+WL N +T P + +M L + + N ++ P + +++L+ V
Sbjct: 160 PGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFP-SLAHLSSLKLVI 218
Query: 275 FRDNPLK 281
+ NP +
Sbjct: 219 YDHNPCR 225
Score = 76.3 bits (186), Expect = 4e-14
Identities = 54/177 (30%), Positives = 85/177 (48%), Gaps = 13/177 (7%)
Query: 104 RFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNR 163
R QN +V DL + ++ + LS ++++ P + + L KL L+ N
Sbjct: 16 RCQNYVVRDLREMPLDKM------------VDLSGSQLRRFPLHVCSFRELVKLYLSDNH 63
Query: 164 DICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQN 223
+ LP EL L L L L N+F +P V + L L +G+NKL LP + +QN
Sbjct: 64 -LNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQN 122
Query: 224 LHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPL 280
L TLW++ N +T LP + + L TL +N L+ +P + + LR + N L
Sbjct: 123 LRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRL 179
Score = 53.1 bits (126), Expect = 3e-07
Identities = 47/211 (22%), Positives = 87/211 (41%), Gaps = 25/211 (11%)
Query: 38 KLVRIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLK 97
+LV+++ L L ++ + IL ++ +K LP + L QL L L
Sbjct: 53 ELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCD 112
Query: 98 IPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKL 157
+P + QNL L + N ++++P + L+ L+ L N ++
Sbjct: 113 LPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRL-------------- 158
Query: 158 ELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDT 217
LP +L L +L + LS N T P +L+MP LE +D+ N + P +
Sbjct: 159 ----------LPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFP-S 207
Query: 218 IERMQNLHTLWLQRNEITCLPQTISNMKNLG 248
+ + +L + N P+ ++ +G
Sbjct: 208 LAHLSSLKLVIYDHNPCRNAPKVAKGVRRVG 238
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 96.7 bits (239), Expect = 3e-20
Identities = 69/236 (29%), Positives = 115/236 (48%), Gaps = 28/236 (11%)
Query: 75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGL-LTRLQE 133
+P + KL+ L L L + P + +N++VL+LS N+I IP + + LT L
Sbjct: 96 VPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLY 155
Query: 134 LILSYNKIKTVPKELSNCASLEKLELAVN-------------------------RDICDL 168
L LS N+++++P ++ L+ L L N R +L
Sbjct: 156 LDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNL 215
Query: 169 PQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLW 228
P L L L +DLS ND T +P + +P+L L++ SN++ +L I++ ++ TL
Sbjct: 216 PTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLN 275
Query: 229 LQRNEITCLPQTISNMKNLGTLVLSNNKL--QDIPVCMEEMANLRFVNFRDNPLKL 282
L RN++T LP I + L L L++NKL +P + ++ NL +N L+L
Sbjct: 276 LSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLEL 331
Score = 90.1 bits (222), Expect = 2e-18
Identities = 64/234 (27%), Positives = 112/234 (47%), Gaps = 30/234 (12%)
Query: 76 PSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELI 135
P ++ + L+ +L+RTGL +PE + Q L L +S N ++ + + L L+ ++
Sbjct: 26 PENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIV 85
Query: 136 LSYNKIKT--VPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPL 193
N +K VP ++ L L+L+ N+ + + P+EL N + L+LS N TIP
Sbjct: 86 ARANSLKNSGVPDDIFKLDDLSVLDLSHNQ-LTECPRELENAKNMLVLNLSHNSIDTIPN 144
Query: 194 AV-LNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEI------------------ 234
+ +N+ L +LD+ N+LE LP + R+ +L TL L N +
Sbjct: 145 QLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLH 204
Query: 235 --------TCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPL 280
+ LP ++ + NL + LS N L +P C+ + +LR +N N +
Sbjct: 205 LRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQI 258
Score = 78.6 bits (192), Expect = 7e-15
Identities = 61/231 (26%), Positives = 112/231 (48%), Gaps = 13/231 (5%)
Query: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLL-----KIPEFIGRFQNLIVLDLSRNTIS 119
L + + ++LP + +L LQ L+ LL ++P + L ++ T S
Sbjct: 156 LDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTAL--QTLHLRSTQRTQS 213
Query: 120 EIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLT 179
+P + L+ L ++ LS N + VP+ L SL +L L+ N+ I +L + + +
Sbjct: 214 NLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQ-ITELSLCIDQWVHVE 272
Query: 180 HLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLE--QLPDTIERMQNLHTLWLQRNEITCL 237
L+LS N T++P A+ + L+ L + SNKL+ LP I ++ NL N + +
Sbjct: 273 TLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELV 332
Query: 238 PQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPP 288
P+++ L LVL+ N L +P + + + ++ R+NP + +PP
Sbjct: 333 PESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENP---NLVMPP 380
Score = 73.2 bits (178), Expect = 3e-13
Identities = 56/169 (33%), Positives = 94/169 (55%), Gaps = 11/169 (6%)
Query: 126 GLLTRLQELILSYNKIKT--VPKELSNCASLEKLELAVNRD-ICDLPQELSNLLKLTHLD 182
G+L ++ + LS N K P+ + SL L+L NR +C LP+EL+ L KL HL
Sbjct: 5 GVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKL--NRTGLCYLPEELAALQKLEHLS 62
Query: 183 LSMNDFTTIPLAVLNMPALEWLDMGSNKLEQ--LPDTIERMQNLHTLWLQRNEITCLPQT 240
+S N+ TT+ + ++P+L + +N L+ +PD I ++ +L L L N++T P+
Sbjct: 63 VSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRE 122
Query: 241 ISNMKNLGTLVLSNNKLQDIP-VCMEEMANLRFVNFRDNPLKLKVSLPP 288
+ N KN+ L LS+N + IP + +L +++ +N L+ SLPP
Sbjct: 123 LENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLE---SLPP 168
Score = 48.1 bits (113), Expect = 1e-05
Identities = 28/125 (22%), Positives = 65/125 (52%), Gaps = 2/125 (1%)
Query: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLL--KIPEFIGRFQNLIVLDLSRNTISEIP 122
L + + + +LPS++ KL++L++ L+ L +P IG+ NL + N + +P
Sbjct: 274 LNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVP 333
Query: 123 PGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLD 182
+ +L++L+L+ N + T+P+ + +E L++ N ++ P+ + ++D
Sbjct: 334 ESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPADRAAEWYNID 393
Query: 183 LSMND 187
S+ +
Sbjct: 394 FSLQN 398
Score = 38.9 bits (89), Expect = 0.007
Identities = 25/92 (27%), Positives = 46/92 (50%)
Query: 62 RVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEI 121
++ L K ++ LPS + KL L+E+ L +PE + R L L L++N + +
Sbjct: 296 KLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTL 355
Query: 122 PPGIGLLTRLQELILSYNKIKTVPKELSNCAS 153
P I LT ++ L + N +P + ++ A+
Sbjct: 356 PEAIHFLTEIEVLDVRENPNLVMPPKPADRAA 387
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 95.9 bits (237), Expect = 5e-20
Identities = 77/279 (27%), Positives = 133/279 (47%), Gaps = 38/279 (13%)
Query: 64 ILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPP 123
+L + ++P S +L ++ E L L K+P I R+ +L +L L + +
Sbjct: 238 VLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRG 297
Query: 124 GIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDL 183
L L+ L LS N + P ++ +LE L L N+ I LP EL +L KL L L
Sbjct: 298 SFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNK-IGQLPSELGSLSKLKILGL 356
Query: 184 SMNDFTTIPLAVLNMPALEWLDMGSN---KLEQLPDTIERMQNLHTLWLQRNEITCLPQT 240
+ N+F + P VL++ +LE L +G + KL +P+ I ++Q+L L+++ N + LP +
Sbjct: 357 TGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVS 416
Query: 241 ISNMKNLGTLVLSNNKLQDIP--VC---------------------MEEMANLRFVNFRD 277
+ +M NL L +N L+ +P +C ++ + NL+ + D
Sbjct: 417 LGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMD 476
Query: 278 NPLKLKVSLPPSEGTDEEEERELFGLQFMHTYIQESRRR 316
NP++ PP E E G + + Y++E+R R
Sbjct: 477 NPME----EPPKEVCAE-------GNEAIWKYLKENRNR 504
Score = 95.1 bits (235), Expect = 8e-20
Identities = 69/255 (27%), Positives = 117/255 (45%), Gaps = 6/255 (2%)
Query: 64 ILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPP 123
+L + K LP ++ +L+E L R P+ + L ++DL N I IP
Sbjct: 146 LLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPE 205
Query: 124 GIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDL 183
IG LT LQ+ ++ N + +P L C+ L L+L+ N + +P+ + L K+T + L
Sbjct: 206 EIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNL-LHSIPKSFAELRKMTEIGL 264
Query: 184 SMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN 243
S N +P + +L L +G+ L +L + + NL L L +N + P I
Sbjct: 265 SGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICA 324
Query: 244 MKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEGTDEEEERELFGL 303
+KNL L L +NK+ +P + ++ L+ + N +S P + E+ G
Sbjct: 325 LKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEF---LSFPEEVLSLASLEKLYIGQ 381
Query: 304 Q--FMHTYIQESRRR 316
F TY+ E R+
Sbjct: 382 DQGFKLTYVPEHIRK 396
Score = 94.0 bits (232), Expect = 2e-19
Identities = 66/247 (26%), Positives = 106/247 (42%), Gaps = 26/247 (10%)
Query: 60 DGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTIS 119
D + + +P + +L+E L + +IP+ I R +N+ VL L +N +
Sbjct: 25 DRTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLR 84
Query: 120 EIPPGIGLLTRLQELILSYNKI------------------------KTVPKEL-SNCASL 154
+ P +GLL+ L+ L LSYN I K +P + N L
Sbjct: 85 SLCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHL 144
Query: 155 EKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQL 214
E L L N C LP+E+ N KL + L N F P + + LE +D+ NK+ +
Sbjct: 145 ELLGLTGNHLKC-LPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAI 203
Query: 215 PDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVN 274
P+ I + L ++ N + LP ++ L L LS+N L IP E+ + +
Sbjct: 204 PEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIG 263
Query: 275 FRDNPLK 281
N L+
Sbjct: 264 LSGNRLE 270
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 93.2 bits (230), Expect = 3e-19
Identities = 76/238 (31%), Positives = 121/238 (50%), Gaps = 5/238 (2%)
Query: 38 KLVRIWEERVSLTKLREKVTREDGRVI-LKIEKEEWKTLP-SSLLKLNQLQEWQLHRTGL 95
K +++ + +L+KL + VT + L I E K + +SL K+ L E +L R L
Sbjct: 544 KRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDL 603
Query: 96 LKIPEFIGRFQNLIVLDLSRNTISEIPPGIGL--LTRLQELILSYNKIKTVPKELSNCAS 153
+IP I NL +DL N + I I L RL L L YN I +P ++ N +
Sbjct: 604 ERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTN 663
Query: 154 LEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQ 213
LE+L L N+ I +P +L KL +LDLS N+ T +P + + L+ L + +N++E
Sbjct: 664 LERLYLNRNK-IEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIET 722
Query: 214 LPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLR 271
LP + + + L L L N + LP + + NL + L N+L+ +PV + E L+
Sbjct: 723 LPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
Score = 87.4 bits (215), Expect = 2e-17
Identities = 71/218 (32%), Positives = 103/218 (47%), Gaps = 12/218 (5%)
Query: 75 LPSSLLKLNQ--------LQEWQLHRTGL-LKIPEFIGRFQNLIVLDLSRNTISEIPPGI 125
L S+L KL Q LQ+ ++ G L + + + NL L+L R + IP I
Sbjct: 551 LKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSI 610
Query: 126 GLLTRLQELILSYNKIKTVPKELS--NCASLEKLELAVNRDICDLPQELSNLLKLTHLDL 183
L LQE+ L N +KT+ + +S + L L+L N I +P ++ NL L L L
Sbjct: 611 FSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNH-IAYIPIQIGNLTNLERLYL 669
Query: 184 SMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN 243
+ N IP + L +LD+ N L LP I +QNL L + N I LP +
Sbjct: 670 NRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQ 729
Query: 244 MKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLK 281
+ L L L NN LQ +P + E+ NL + R N L+
Sbjct: 730 CRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLE 767
Score = 72.4 bits (176), Expect = 5e-13
Identities = 67/248 (27%), Positives = 110/248 (44%), Gaps = 31/248 (12%)
Query: 64 ILKIEKEEWKTLPSSLLKLNQLQE-WQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIP 122
+LK+E T+P S+ +L L+E W H ++ P +NL L + I EIP
Sbjct: 450 VLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIP 509
Query: 123 PGIGLLTRLQELILSYN-----------------KIKTVPKELSNCASLEKL-------- 157
I L L+EL L+ N K V + SN + L ++
Sbjct: 510 LWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHL 569
Query: 158 -ELAVNRDICDL--PQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQL 214
+L++N + L L + LT L+L D IP ++ ++ L+ +D+ N L+ +
Sbjct: 570 QKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTI 629
Query: 215 PDTI--ERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRF 272
+ I + + L L L N I +P I N+ NL L L+ NK++ IP + LR+
Sbjct: 630 EEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRY 689
Query: 273 VNFRDNPL 280
++ N L
Sbjct: 690 LDLSHNNL 697
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 93.2 bits (230), Expect = 3e-19
Identities = 76/238 (31%), Positives = 121/238 (50%), Gaps = 5/238 (2%)
Query: 38 KLVRIWEERVSLTKLREKVTREDGRVI-LKIEKEEWKTLP-SSLLKLNQLQEWQLHRTGL 95
K +++ + +L+KL + VT + L I E K + +SL K+ L E +L R L
Sbjct: 544 KRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDL 603
Query: 96 LKIPEFIGRFQNLIVLDLSRNTISEIPPGIGL--LTRLQELILSYNKIKTVPKELSNCAS 153
+IP I NL +DL N + I I L RL L L YN I +P ++ N +
Sbjct: 604 ERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTN 663
Query: 154 LEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQ 213
LE+L L N+ I +P +L KL +LDLS N+ T +P + + L+ L + +N++E
Sbjct: 664 LERLYLNRNK-IEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIET 722
Query: 214 LPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLR 271
LP + + + L L L N + LP + + NL + L N+L+ +PV + E L+
Sbjct: 723 LPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
Score = 87.4 bits (215), Expect = 2e-17
Identities = 71/218 (32%), Positives = 103/218 (47%), Gaps = 12/218 (5%)
Query: 75 LPSSLLKLNQ--------LQEWQLHRTGL-LKIPEFIGRFQNLIVLDLSRNTISEIPPGI 125
L S+L KL Q LQ+ ++ G L + + + NL L+L R + IP I
Sbjct: 551 LKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSI 610
Query: 126 GLLTRLQELILSYNKIKTVPKELS--NCASLEKLELAVNRDICDLPQELSNLLKLTHLDL 183
L LQE+ L N +KT+ + +S + L L+L N I +P ++ NL L L L
Sbjct: 611 FSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNH-IAYIPIQIGNLTNLERLYL 669
Query: 184 SMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN 243
+ N IP + L +LD+ N L LP I +QNL L + N I LP +
Sbjct: 670 NRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQ 729
Query: 244 MKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLK 281
+ L L L NN LQ +P + E+ NL + R N L+
Sbjct: 730 CRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLE 767
Score = 72.4 bits (176), Expect = 5e-13
Identities = 67/248 (27%), Positives = 110/248 (44%), Gaps = 31/248 (12%)
Query: 64 ILKIEKEEWKTLPSSLLKLNQLQE-WQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIP 122
+LK+E T+P S+ +L L+E W H ++ P +NL L + I EIP
Sbjct: 450 VLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIP 509
Query: 123 PGIGLLTRLQELILSYN-----------------KIKTVPKELSNCASLEKL-------- 157
I L L+EL L+ N K V + SN + L ++
Sbjct: 510 LWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHL 569
Query: 158 -ELAVNRDICDL--PQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQL 214
+L++N + L L + LT L+L D IP ++ ++ L+ +D+ N L+ +
Sbjct: 570 QKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTI 629
Query: 215 PDTI--ERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRF 272
+ I + + L L L N I +P I N+ NL L L+ NK++ IP + LR+
Sbjct: 630 EEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRY 689
Query: 273 VNFRDNPL 280
++ N L
Sbjct: 690 LDLSHNNL 697
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 93.2 bits (230), Expect = 3e-19
Identities = 76/238 (31%), Positives = 121/238 (50%), Gaps = 5/238 (2%)
Query: 38 KLVRIWEERVSLTKLREKVTREDGRVI-LKIEKEEWKTLP-SSLLKLNQLQEWQLHRTGL 95
K +++ + +L+KL + VT + L I E K + +SL K+ L E +L R L
Sbjct: 544 KRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDL 603
Query: 96 LKIPEFIGRFQNLIVLDLSRNTISEIPPGIGL--LTRLQELILSYNKIKTVPKELSNCAS 153
+IP I NL +DL N + I I L RL L L YN I +P ++ N +
Sbjct: 604 ERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTN 663
Query: 154 LEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQ 213
LE+L L N+ I +P +L KL +LDLS N+ T +P + + L+ L + +N++E
Sbjct: 664 LERLYLNRNK-IEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIET 722
Query: 214 LPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLR 271
LP + + + L L L N + LP + + NL + L N+L+ +PV + E L+
Sbjct: 723 LPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
Score = 87.4 bits (215), Expect = 2e-17
Identities = 71/218 (32%), Positives = 103/218 (47%), Gaps = 12/218 (5%)
Query: 75 LPSSLLKLNQ--------LQEWQLHRTGL-LKIPEFIGRFQNLIVLDLSRNTISEIPPGI 125
L S+L KL Q LQ+ ++ G L + + + NL L+L R + IP I
Sbjct: 551 LKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSI 610
Query: 126 GLLTRLQELILSYNKIKTVPKELS--NCASLEKLELAVNRDICDLPQELSNLLKLTHLDL 183
L LQE+ L N +KT+ + +S + L L+L N I +P ++ NL L L L
Sbjct: 611 FSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNH-IAYIPIQIGNLTNLERLYL 669
Query: 184 SMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN 243
+ N IP + L +LD+ N L LP I +QNL L + N I LP +
Sbjct: 670 NRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQ 729
Query: 244 MKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLK 281
+ L L L NN LQ +P + E+ NL + R N L+
Sbjct: 730 CRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLE 767
Score = 72.4 bits (176), Expect = 5e-13
Identities = 67/248 (27%), Positives = 110/248 (44%), Gaps = 31/248 (12%)
Query: 64 ILKIEKEEWKTLPSSLLKLNQLQE-WQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIP 122
+LK+E T+P S+ +L L+E W H ++ P +NL L + I EIP
Sbjct: 450 VLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIP 509
Query: 123 PGIGLLTRLQELILSYN-----------------KIKTVPKELSNCASLEKL-------- 157
I L L+EL L+ N K V + SN + L ++
Sbjct: 510 LWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHL 569
Query: 158 -ELAVNRDICDL--PQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQL 214
+L++N + L L + LT L+L D IP ++ ++ L+ +D+ N L+ +
Sbjct: 570 QKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTI 629
Query: 215 PDTI--ERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRF 272
+ I + + L L L N I +P I N+ NL L L+ NK++ IP + LR+
Sbjct: 630 EEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRY 689
Query: 273 VNFRDNPL 280
++ N L
Sbjct: 690 LDLSHNNL 697
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 90.5 bits (223), Expect = 2e-18
Identities = 77/247 (31%), Positives = 124/247 (50%), Gaps = 7/247 (2%)
Query: 29 LKREKEFQHKLVRIWEERVSLTKLREKVTREDGRVI-LKIEKEEWKTLP-SSLLKLNQLQ 86
L+ +E +H ++I + +LTK+ +T + L I + K L +SL K+ +
Sbjct: 581 LESLRELRH--LKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVA 638
Query: 87 EWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGL--LTRLQELILSYNKIKTV 144
E +L L +IP I NL LDL N I I I L RL L L +NKI T+
Sbjct: 639 ELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTI 698
Query: 145 PKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWL 204
P +++ +LE L + N+ + LP + +L KL LD+S N+ + IP+ + + L+ L
Sbjct: 699 PPSITHVKNLESLYFSNNK-LESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHL 757
Query: 205 DMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCM 264
+ NK++ LP + + L TL L +N IT LP+ + + L L L N L +P +
Sbjct: 758 HITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQL 817
Query: 265 EEMANLR 271
+ L+
Sbjct: 818 GQCRMLK 824
Score = 75.5 bits (184), Expect = 6e-14
Identities = 58/216 (26%), Positives = 105/216 (48%), Gaps = 5/216 (2%)
Query: 69 KEEWKTLPSSLLKLN-QLQEWQLHRTGL-LKIPEFIGRFQNLIVLDLSRNTISEIPPGIG 126
K +PS++ + L + +H G L + + + N+ L+L + IP I
Sbjct: 596 KSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIF 655
Query: 127 LLTRLQELILSYNKIKTVPKELS--NCASLEKLELAVNRDICDLPQELSNLLKLTHLDLS 184
L+ LQEL L N I+T+ + +S + L L+L N+ I +P ++++ L L S
Sbjct: 656 SLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNK-IVTIPPSITHVKNLESLYFS 714
Query: 185 MNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNM 244
N ++P+AV ++ L LD+ N + +P I +QNL L + N++ LP+ +
Sbjct: 715 NNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKC 774
Query: 245 KNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPL 280
L TL L N + +P + +++ L + + N L
Sbjct: 775 IKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCL 810
Score = 47.0 bits (110), Expect = 2e-05
Identities = 64/277 (23%), Positives = 106/277 (38%), Gaps = 77/277 (27%)
Query: 83 NQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIK 142
N + +LH L +P+ + +L VL L ++IP I +T LQEL L + K
Sbjct: 467 NAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAK 526
Query: 143 TVPKELSNCASLEKLELAVNRDICDLPQ-------------------------ELSNLLK 177
S + D+ ++P L +L +
Sbjct: 527 VEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRE 586
Query: 178 LTHLDL--SMNDFTTIP---------------------LAVLN----MPALEWLDMGSNK 210
L HL + ++ T +P L VLN M + L++ + +
Sbjct: 587 LRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCE 646
Query: 211 LEQLPDTIERMQNLHTLWLQRNEI---------------TCL----------PQTISNMK 245
LE++P I + NL L L+ N I TCL P +I+++K
Sbjct: 647 LERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVK 706
Query: 246 NLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKL 282
NL +L SNNKL+ +PV + + LR ++ N + +
Sbjct: 707 NLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISM 743
Score = 35.8 bits (81), Expect = 0.055
Identities = 24/93 (25%), Positives = 44/93 (47%), Gaps = 11/93 (11%)
Query: 75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQE- 133
LP L K +L+ L + + +PE +G+ L L+L N + +P +G L++
Sbjct: 767 LPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKS 826
Query: 134 -LILSYNKIKTVPKELSNCASLEKLELAVNRDI 165
L++ + T+P E+ A+N+DI
Sbjct: 827 GLVVEDHLFDTLPLEVKE---------ALNQDI 850
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 90.5 bits (223), Expect = 2e-18
Identities = 77/247 (31%), Positives = 124/247 (50%), Gaps = 7/247 (2%)
Query: 29 LKREKEFQHKLVRIWEERVSLTKLREKVTREDGRVI-LKIEKEEWKTLP-SSLLKLNQLQ 86
L+ +E +H ++I + +LTK+ +T + L I + K L +SL K+ +
Sbjct: 581 LESLRELRH--LKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVA 638
Query: 87 EWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGL--LTRLQELILSYNKIKTV 144
E +L L +IP I NL LDL N I I I L RL L L +NKI T+
Sbjct: 639 ELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTI 698
Query: 145 PKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWL 204
P +++ +LE L + N+ + LP + +L KL LD+S N+ + IP+ + + L+ L
Sbjct: 699 PPSITHVKNLESLYFSNNK-LESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHL 757
Query: 205 DMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCM 264
+ NK++ LP + + L TL L +N IT LP+ + + L L L N L +P +
Sbjct: 758 HITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQL 817
Query: 265 EEMANLR 271
+ L+
Sbjct: 818 GQCRMLK 824
Score = 75.5 bits (184), Expect = 6e-14
Identities = 58/216 (26%), Positives = 105/216 (48%), Gaps = 5/216 (2%)
Query: 69 KEEWKTLPSSLLKLN-QLQEWQLHRTGL-LKIPEFIGRFQNLIVLDLSRNTISEIPPGIG 126
K +PS++ + L + +H G L + + + N+ L+L + IP I
Sbjct: 596 KSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIF 655
Query: 127 LLTRLQELILSYNKIKTVPKELS--NCASLEKLELAVNRDICDLPQELSNLLKLTHLDLS 184
L+ LQEL L N I+T+ + +S + L L+L N+ I +P ++++ L L S
Sbjct: 656 SLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNK-IVTIPPSITHVKNLESLYFS 714
Query: 185 MNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNM 244
N ++P+AV ++ L LD+ N + +P I +QNL L + N++ LP+ +
Sbjct: 715 NNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKC 774
Query: 245 KNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPL 280
L TL L N + +P + +++ L + + N L
Sbjct: 775 IKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCL 810
Score = 47.0 bits (110), Expect = 2e-05
Identities = 64/277 (23%), Positives = 106/277 (38%), Gaps = 77/277 (27%)
Query: 83 NQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIK 142
N + +LH L +P+ + +L VL L ++IP I +T LQEL L + K
Sbjct: 467 NAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAK 526
Query: 143 TVPKELSNCASLEKLELAVNRDICDLPQ-------------------------ELSNLLK 177
S + D+ ++P L +L +
Sbjct: 527 VEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRE 586
Query: 178 LTHLDL--SMNDFTTIP---------------------LAVLN----MPALEWLDMGSNK 210
L HL + ++ T +P L VLN M + L++ + +
Sbjct: 587 LRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCE 646
Query: 211 LEQLPDTIERMQNLHTLWLQRNEI---------------TCL----------PQTISNMK 245
LE++P I + NL L L+ N I TCL P +I+++K
Sbjct: 647 LERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVK 706
Query: 246 NLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKL 282
NL +L SNNKL+ +PV + + LR ++ N + +
Sbjct: 707 NLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISM 743
Score = 35.8 bits (81), Expect = 0.055
Identities = 24/93 (25%), Positives = 44/93 (47%), Gaps = 11/93 (11%)
Query: 75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQE- 133
LP L K +L+ L + + +PE +G+ L L+L N + +P +G L++
Sbjct: 767 LPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKS 826
Query: 134 -LILSYNKIKTVPKELSNCASLEKLELAVNRDI 165
L++ + T+P E+ A+N+DI
Sbjct: 827 GLVVEDHLFDTLPLEVKE---------ALNQDI 850
>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
Length = 347
Score = 90.5 bits (223), Expect = 2e-18
Identities = 54/188 (28%), Positives = 98/188 (52%)
Query: 95 LLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASL 154
+ K+P +G+ L L L N I ++ P + LT+L L L N ++ VP+E+ SL
Sbjct: 26 MTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTSL 85
Query: 155 EKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQL 214
+ L L+ NR P L L L+L+ N T +P V + +L ++ + N+L +
Sbjct: 86 KNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASI 145
Query: 215 PDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVN 274
P + ++NL L L N++ C+P+ I +K L L+L+ N + +P + ++ LR ++
Sbjct: 146 PRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILD 205
Query: 275 FRDNPLKL 282
N +++
Sbjct: 206 IAGNIIQI 213
Score = 87.4 bits (215), Expect = 2e-17
Identities = 65/221 (29%), Positives = 110/221 (49%), Gaps = 3/221 (1%)
Query: 64 ILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPP 123
I+ + ++ +PS+L KL L+ L + K+ + L L+L N + E+P
Sbjct: 18 IITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPE 77
Query: 124 GIGLLTRLQELILSYNKI-KTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLD 182
+ LT L+ L LS N+I + P +L L L N + LPQE+S L LT++
Sbjct: 78 EMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLN-NNHLTQLPQEVSRLKSLTYMS 136
Query: 183 LSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTIS 242
++ N +IP + + L L + N+L +P+ I+ ++ L L L RN I LP+ +
Sbjct: 137 INYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELC 196
Query: 243 NMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLK 283
++K L L ++ N +Q P +++ LR NPL L+
Sbjct: 197 DLKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGNPLFLQ 236
Score = 63.5 bits (153), Expect = 2e-10
Identities = 44/152 (28%), Positives = 78/152 (51%), Gaps = 1/152 (0%)
Query: 76 PSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELI 135
P + L L L+ L ++P+ + R ++L + ++ N ++ IP + L L EL
Sbjct: 100 PGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQ 159
Query: 136 LSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAV 195
L+YN++ +P+E+ L+KL LA N +I LP+EL +L KL LD++ N P
Sbjct: 160 LNYNQLICIPEEIKFLKKLQKLLLARN-NIGVLPEELCDLKKLRILDIAGNIIQIFPSGF 218
Query: 196 LNMPALEWLDMGSNKLEQLPDTIERMQNLHTL 227
++ E+ G+ Q P + +N+ +L
Sbjct: 219 QDLKLREFYCEGNPLFLQQPVISTQQENVWSL 250
Score = 52.4 bits (124), Expect = 6e-07
Identities = 30/100 (30%), Positives = 51/100 (51%)
Query: 63 VILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIP 122
++L + LP + +L L ++ L IP + +NL+ L L+ N + IP
Sbjct: 110 ILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIP 169
Query: 123 PGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVN 162
I L +LQ+L+L+ N I +P+EL + L L++A N
Sbjct: 170 EEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGN 209
Score = 43.1 bits (100), Expect = 3e-04
Identities = 31/97 (31%), Positives = 50/97 (51%)
Query: 49 LTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNL 108
LT+L ++V+R + I + ++P L L L E QL+ L+ IPE I + L
Sbjct: 119 LTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKL 178
Query: 109 IVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVP 145
L L+RN I +P + L +L+ L ++ N I+ P
Sbjct: 179 QKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFP 215
>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
sapiens]
Length = 796
Score = 87.4 bits (215), Expect = 2e-17
Identities = 61/183 (33%), Positives = 94/183 (51%), Gaps = 8/183 (4%)
Query: 75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQN---LIVLDLSRNTISEIPPGIGLLTRL 131
+P ++ L LQE L L I E + FQ+ L+ L L N I+ +P + L L
Sbjct: 597 IPHAVFSLGALQELDLKDNHLRSIEEILS-FQHCRKLVTLRLWHNQIAYVPEHVRKLRSL 655
Query: 132 QELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTI 191
++L LSYNK++T+P +L C+ L L+++ N + LP E+ L L HL LS N +
Sbjct: 656 EQLYLSYNKLETLPSQLGLCSGLRLLDVSHN-GLHSLPPEVGLLQNLQHLALSYNALEAL 714
Query: 192 PLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN---MKNLG 248
P + L L +G N+L QL + ++ L L L+ N + LP+ + N +K G
Sbjct: 715 PEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAG 774
Query: 249 TLV 251
LV
Sbjct: 775 LLV 777
Score = 72.0 bits (175), Expect = 7e-13
Identities = 71/258 (27%), Positives = 111/258 (43%), Gaps = 12/258 (4%)
Query: 27 EDLKREKEFQHKLVRIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQ 86
E+L E F +L R +L LRE + +L + K S LQ
Sbjct: 510 EELHLEGLFPQELARA----ATLESLRELKQLK----VLSLRSNAGKVPASVTDVAGHLQ 561
Query: 87 EWQLHRTGLLKIP-EFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVP 145
LH G + + + L L+L + IP + L LQEL L N ++++
Sbjct: 562 RLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIE 621
Query: 146 KELS--NCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEW 203
+ LS +C L L L N+ I +P+ + L L L LS N T+P + L
Sbjct: 622 EILSFQHCRKLVTLRLWHNQ-IAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRL 680
Query: 204 LDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVC 263
LD+ N L LP + +QNL L L N + LP+ + + L TL+L +N+L +
Sbjct: 681 LDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPH 740
Query: 264 MEEMANLRFVNFRDNPLK 281
+ + L + + N L+
Sbjct: 741 VGALRALSRLELKGNRLE 758
Score = 71.2 bits (173), Expect = 1e-12
Identities = 51/172 (29%), Positives = 83/172 (48%), Gaps = 8/172 (4%)
Query: 31 REKEFQHKLVRIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQL 90
+E + + +R EE +S R+ VT L++ + +P + KL L++ L
Sbjct: 608 QELDLKDNHLRSIEEILSFQHCRKLVT-------LRLWHNQIAYVPEHVRKLRSLEQLYL 660
Query: 91 HRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSN 150
L +P +G L +LD+S N + +PP +GLL LQ L LSYN ++ +P+EL
Sbjct: 661 SYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFF 720
Query: 151 CASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALE 202
C L L L N+ + L + L L+ L+L N +P + N L+
Sbjct: 721 CRKLRTLLLGDNQ-LSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLK 771
Score = 55.8 bits (133), Expect = 5e-08
Identities = 49/171 (28%), Positives = 75/171 (43%), Gaps = 30/171 (17%)
Query: 35 FQH--KLV--RIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQL 90
FQH KLV R+W +++ + R ++ L K E TLPS L + L+ +
Sbjct: 626 FQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLE--TLPSQLGLCSGLRLLDV 683
Query: 91 HRTGLLKIPEFIGRFQNLIVLDLSRNTISEIP-----------------------PGIGL 127
GL +P +G QNL L LS N + +P P +G
Sbjct: 684 SHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGA 743
Query: 128 LTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICD-LPQELSNLLK 177
L L L L N+++ +P+EL NC L+K L V + LP E+ + ++
Sbjct: 744 LRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDTLYQGLPAEVRDKME 794
>gi|14249428 leucine-rich repeats and calponin homology (CH) domain
containing 3 [Homo sapiens]
Length = 712
Score = 87.4 bits (215), Expect = 2e-17
Identities = 71/228 (31%), Positives = 113/228 (49%), Gaps = 15/228 (6%)
Query: 90 LHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELS 149
L R L +IP F +L L+L +N I IP I L L L +S N++ T+P L
Sbjct: 89 LSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLC 148
Query: 150 NCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSN 209
N K+ +A N + LP+E+ +L L LD+S N+ TIP + N+ AL L++ N
Sbjct: 149 NLPL--KVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRN 206
Query: 210 KLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIP--VCMEEM 267
L LP+ + + L L N+IT +P N+++L T+ L NN LQ P +C++
Sbjct: 207 HLVHLPEELAELP-LIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQICIKGK 265
Query: 268 ANL-RFVNFRDNPLKLKVSLPPSEGTDEEEERELFGLQFMHTYIQESR 314
++ +++N + K+ LP + +R G H + SR
Sbjct: 266 VHIFKYLNIQ--ACKIAPDLP-------DYDRRPLGFGSCHEELYSSR 304
Score = 58.9 bits (141), Expect = 6e-09
Identities = 54/195 (27%), Positives = 94/195 (48%), Gaps = 13/195 (6%)
Query: 142 KTVPKELSNCASLEKLELAVNRDICDLPQELSN--LLKLTHLDLSMNDFTTIPLAVLNMP 199
+++ + L A L L+ R + + P+ +N L T DLS N + IP+ +
Sbjct: 47 RSLDRALEEAAVTGVLSLS-GRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFV 105
Query: 200 ALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQD 259
+LE L++ N + +P+ I +Q L L + RN+++ LP + N+ L L+ SNNKL
Sbjct: 106 SLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIASNNKLVS 164
Query: 260 IPVCMEEMANLRFVNFRDNPLKLKVSLPPSEGTDEEEERELFGLQFMHTYIQESRR---- 315
+P EE+ +LR + D ++ PS+ + E R+L + ++ E
Sbjct: 165 LP---EEIGHLRHLMELDVSCN-EIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPL 220
Query: 316 -RADHQVNGSTTLPI 329
R D N TT+P+
Sbjct: 221 IRLDFSCNKITTIPV 235
Score = 42.0 bits (97), Expect = 8e-04
Identities = 34/112 (30%), Positives = 53/112 (47%), Gaps = 11/112 (9%)
Query: 37 HKLVRIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLL 96
+KLV + EE L L E L + E +T+PS + L L++ + R L+
Sbjct: 160 NKLVSLPEEIGHLRHLME----------LDVSCNEIQTIPSQIGNLEALRDLNVRRNHLV 209
Query: 97 KIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKEL 148
+PE + LI LD S N I+ IP L LQ + L N +++ P ++
Sbjct: 210 HLPEELAELP-LIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQI 260
>gi|154091020 leucine-rich repeats and calponin homology (CH) domain
containing 2 [Homo sapiens]
Length = 765
Score = 87.0 bits (214), Expect = 2e-17
Identities = 58/179 (32%), Positives = 100/179 (55%), Gaps = 7/179 (3%)
Query: 112 DLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQE 171
DLSRN +EIP + L L+ L L +N IKT+P+ + N L L ++ N + LP+
Sbjct: 117 DLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNL-LSTLPKY 175
Query: 172 LSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQR 231
L + L L L +S N +IP + + L LD+ N+++ LP + ++ +L L ++R
Sbjct: 176 LFD-LPLKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRR 234
Query: 232 NEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSE 290
N + LP + ++ L L S NK+ +IPVC ++ +L+ + +NPL+ +PP++
Sbjct: 235 NNLHVLPDELGDLP-LVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQ----VPPAQ 288
Score = 78.2 bits (191), Expect = 1e-14
Identities = 59/216 (27%), Positives = 102/216 (47%), Gaps = 6/216 (2%)
Query: 64 ILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPP 123
IL + + + P S L + L R +IP + F L L+L N I IP
Sbjct: 92 ILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPE 151
Query: 124 GIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDL 183
I L L L +S N + T+PK L + K+ + N + +P+E+ L L LD+
Sbjct: 152 AIKNLQMLTYLNISRNLLSTLPKYLFDLPL--KVLVVSNNKLVSIPEEIGKLKDLMELDI 209
Query: 184 SMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN 243
S N+ +P + + +L L++ N L LPD + + L L N++T +P
Sbjct: 210 SCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLP-LVKLDFSCNKVTEIPVCYRK 268
Query: 244 MKNLGTLVLSNNKLQDIP--VCMEEMANL-RFVNFR 276
+ +L ++L NN LQ P +C++ ++ +++N +
Sbjct: 269 LHHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQ 304
Score = 60.8 bits (146), Expect = 2e-09
Identities = 44/131 (33%), Positives = 70/131 (53%), Gaps = 5/131 (3%)
Query: 141 IKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPA 200
++++ + L S L L+ R + D P +L T DLS N FT IP V
Sbjct: 77 VRSLDRALEEAGSSGILSLS-GRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAP 135
Query: 201 LEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDI 260
LE L++ N ++ +P+ I+ +Q L L + RN ++ LP+ + ++ L LV+SNNKL I
Sbjct: 136 LETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSI 194
Query: 261 PVCMEEMANLR 271
P EE+ L+
Sbjct: 195 P---EEIGKLK 202
Score = 48.1 bits (113), Expect = 1e-05
Identities = 50/166 (30%), Positives = 70/166 (42%), Gaps = 31/166 (18%)
Query: 37 HKLVRIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLL 96
+KLV I EE L L E L I E + LP + KL+ L+E + R L
Sbjct: 189 NKLVSIPEEIGKLKDLME----------LDISCNEIQVLPQQMGKLHSLRELNIRRNNLH 238
Query: 97 KIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKE--------- 147
+P+ +G L+ LD S N ++EIP L LQ +IL N ++ P +
Sbjct: 239 VLPDELGDLP-LVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHI 297
Query: 148 -----LSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDF 188
+ C ++K D DLP LS + L SM DF
Sbjct: 298 FKYLNIQACCRMDK-----KPDSLDLP-SLSKRMPSQPLTDSMEDF 337
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 86.7 bits (213), Expect = 3e-17
Identities = 63/223 (28%), Positives = 112/223 (50%), Gaps = 13/223 (5%)
Query: 75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLD---------LSRNTISEIPPGI 125
L L+L+ ++ QL L ++P+ + ++L++ R ++ +P G+
Sbjct: 62 LQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGL 121
Query: 126 GLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSM 185
L L L LS+N ++T+P + L L L+ N + +LP+ L L LT L ++
Sbjct: 122 SGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNC-LSELPEALGALPALTFLTVTH 180
Query: 186 NDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMK 245
N T+P A+ + L+ LD+ N L+ LP I + +L L L N + LP +++ ++
Sbjct: 181 NRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLR 240
Query: 246 NLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPP 288
+L LVL +N L +P + + L ++ RDN L+ LPP
Sbjct: 241 SLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLR---DLPP 280
Score = 82.8 bits (203), Expect = 4e-16
Identities = 50/143 (34%), Positives = 76/143 (53%), Gaps = 1/143 (0%)
Query: 73 KTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQ 132
+TLP+ +L++ L L L ++PE +G L L ++ N + +PP +G L+ LQ
Sbjct: 138 ETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQ 197
Query: 133 ELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIP 192
L LS N + T+P E+ SL +L LA NR + LP L+ L L L L N ++P
Sbjct: 198 RLDLSQNLLDTLPPEIGGLGSLLELNLASNR-LQSLPASLAGLRSLRLLVLHSNLLASVP 256
Query: 193 LAVLNMPALEWLDMGSNKLEQLP 215
+ +P L LD+ N+L LP
Sbjct: 257 ADLARLPLLTRLDLRDNQLRDLP 279
Score = 55.1 bits (131), Expect = 9e-08
Identities = 38/124 (30%), Positives = 64/124 (51%), Gaps = 1/124 (0%)
Query: 49 LTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNL 108
L++L E + L + +TLP +L L+ LQ L + L +P IG +L
Sbjct: 160 LSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSL 219
Query: 109 IVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDL 168
+ L+L+ N + +P + L L+ L+L N + +VP +L+ L +L+L N+ + DL
Sbjct: 220 LELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQ-LRDL 278
Query: 169 PQEL 172
P EL
Sbjct: 279 PPEL 282
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 86.7 bits (213), Expect = 3e-17
Identities = 63/223 (28%), Positives = 112/223 (50%), Gaps = 13/223 (5%)
Query: 75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLD---------LSRNTISEIPPGI 125
L L+L+ ++ QL L ++P+ + ++L++ R ++ +P G+
Sbjct: 62 LQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGL 121
Query: 126 GLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSM 185
L L L LS+N ++T+P + L L L+ N + +LP+ L L LT L ++
Sbjct: 122 SGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNC-LSELPEALGALPALTFLTVTH 180
Query: 186 NDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMK 245
N T+P A+ + L+ LD+ N L+ LP I + +L L L N + LP +++ ++
Sbjct: 181 NRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLR 240
Query: 246 NLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPP 288
+L LVL +N L +P + + L ++ RDN L+ LPP
Sbjct: 241 SLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLR---DLPP 280
Score = 82.8 bits (203), Expect = 4e-16
Identities = 50/143 (34%), Positives = 76/143 (53%), Gaps = 1/143 (0%)
Query: 73 KTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQ 132
+TLP+ +L++ L L L ++PE +G L L ++ N + +PP +G L+ LQ
Sbjct: 138 ETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQ 197
Query: 133 ELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIP 192
L LS N + T+P E+ SL +L LA NR + LP L+ L L L L N ++P
Sbjct: 198 RLDLSQNLLDTLPPEIGGLGSLLELNLASNR-LQSLPASLAGLRSLRLLVLHSNLLASVP 256
Query: 193 LAVLNMPALEWLDMGSNKLEQLP 215
+ +P L LD+ N+L LP
Sbjct: 257 ADLARLPLLTRLDLRDNQLRDLP 279
Score = 55.1 bits (131), Expect = 9e-08
Identities = 38/124 (30%), Positives = 64/124 (51%), Gaps = 1/124 (0%)
Query: 49 LTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNL 108
L++L E + L + +TLP +L L+ LQ L + L +P IG +L
Sbjct: 160 LSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSL 219
Query: 109 IVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDL 168
+ L+L+ N + +P + L L+ L+L N + +VP +L+ L +L+L N+ + DL
Sbjct: 220 LELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQ-LRDL 278
Query: 169 PQEL 172
P EL
Sbjct: 279 PPEL 282
>gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
Length = 803
Score = 86.3 bits (212), Expect = 4e-17
Identities = 60/199 (30%), Positives = 91/199 (45%), Gaps = 26/199 (13%)
Query: 75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIG--RFQNLIVLDLSRNTISEIPPGIGLLTRLQ 132
+P S+ LN L E L L + E I QNL L L N I+ IP IG L+ L+
Sbjct: 600 IPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLE 659
Query: 133 ELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIP 192
+L L +N I+ +P +L C KL +LDLS N T IP
Sbjct: 660 QLSLDHNNIENLPLQLFLCT------------------------KLHYLDLSYNHLTFIP 695
Query: 193 LAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVL 252
+ + L++ + +N +E LPD + + + L L L +N + L + + NL L L
Sbjct: 696 EEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLEL 755
Query: 253 SNNKLQDIPVCMEEMANLR 271
N L+ +P +E +L+
Sbjct: 756 IGNYLETLPPELEGCQSLK 774
Score = 76.6 bits (187), Expect = 3e-14
Identities = 63/210 (30%), Positives = 99/210 (47%), Gaps = 7/210 (3%)
Query: 82 LNQLQEWQLHRTGL-LKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNK 140
L LQ+ L G L + + + NL L+L + IP I L L EL L N
Sbjct: 560 LPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENN 619
Query: 141 IKTVPKELS--NCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNM 198
+KTV + +S + +L L+L N +I +P ++ L L L L N+ +PL +
Sbjct: 620 LKTVEEIISFQHLQNLSCLKLWHN-NIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLC 678
Query: 199 PALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQ 258
L +LD+ N L +P+ I+ + NL + N I LP + K L L+L N L
Sbjct: 679 TKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLM 738
Query: 259 DIPVCMEEMANLRFVNFRDNPLKLKVSLPP 288
++ + E++NL + N L+ +LPP
Sbjct: 739 NLSPHVGELSNLTHLELIGNYLE---TLPP 765
Score = 47.8 bits (112), Expect = 1e-05
Identities = 62/271 (22%), Positives = 116/271 (42%), Gaps = 65/271 (23%)
Query: 71 EW--KTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLL 128
EW + L S L+K N + +LH L +P+ + + VL L ++P + L
Sbjct: 404 EWTVEKLKSKLVK-NAQDKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQL 462
Query: 129 TRLQE------------------------LILSYNKIKTVPKELSNCASLEKLELAVNRD 164
L+E L L + ++ +P+ + + +L++L L+
Sbjct: 463 VNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSG--- 519
Query: 165 ICDLPQELSNL----------LKLTHLDLSMNDFTTI------------------PLAVL 196
C LP++LS + L+ +L S++ + L VL
Sbjct: 520 -CVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVL 578
Query: 197 N----MPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTIS--NMKNLGTL 250
N M L+ L++ S LE++P +I + NLH L L+ N + + + IS +++NL L
Sbjct: 579 NNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCL 638
Query: 251 VLSNNKLQDIPVCMEEMANLRFVNFRDNPLK 281
L +N + IP + ++NL ++ N ++
Sbjct: 639 KLWHNNIAYIPAQIGALSNLEQLSLDHNNIE 669
Score = 46.2 bits (108), Expect = 4e-05
Identities = 28/104 (26%), Positives = 56/104 (53%), Gaps = 1/104 (0%)
Query: 75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQEL 134
+P + L+ LQ + + + +P+ + + + L L L +N++ + P +G L+ L L
Sbjct: 694 IPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHL 753
Query: 135 ILSYNKIKTVPKELSNCASLEKLELAVNRDICD-LPQELSNLLK 177
L N ++T+P EL C SL++ L V ++ + LP ++ L+
Sbjct: 754 ELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPLPVTERLQ 797
Score = 45.4 bits (106), Expect = 7e-05
Identities = 38/133 (28%), Positives = 57/133 (42%), Gaps = 3/133 (2%)
Query: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPG 124
L ++ + LP L +L L L IPE I NL ++ N I +P G
Sbjct: 661 LSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDG 720
Query: 125 IGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNL--LKLTHLD 182
+ +LQ L+L N + + + ++L LEL + + LP EL LK L
Sbjct: 721 LFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLEL-IGNYLETLPPELEGCQSLKRNCLI 779
Query: 183 LSMNDFTTIPLAV 195
+ N T+PL V
Sbjct: 780 VEENLLNTLPLPV 792
Score = 34.3 bits (77), Expect = 0.16
Identities = 44/170 (25%), Positives = 75/170 (44%), Gaps = 14/170 (8%)
Query: 136 LSYNKIKTVPKELSNCASLEKLELAVNRDICD-----------LPQELSNLLKLTHLDLS 184
+S NK+K + L+N ++EKL+ + ++ D LP + L ++ L L
Sbjct: 391 VSENKLKQI--NLNNEWTVEKLKSKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLE 448
Query: 185 MNDFTTIPLAVLNMPALEWLDM-GSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN 243
+ +P AV + L+ L + S+ + P +NL L L+ E+ +P+ + +
Sbjct: 449 LIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFH 508
Query: 244 MKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEGTD 293
+KNL L LS L + M+ N R LK +S P TD
Sbjct: 509 LKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTD 558
>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
sapiens]
Length = 803
Score = 86.3 bits (212), Expect = 4e-17
Identities = 60/199 (30%), Positives = 91/199 (45%), Gaps = 26/199 (13%)
Query: 75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIG--RFQNLIVLDLSRNTISEIPPGIGLLTRLQ 132
+P S+ LN L E L L + E I QNL L L N I+ IP IG L+ L+
Sbjct: 600 IPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLE 659
Query: 133 ELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIP 192
+L L +N I+ +P +L C KL +LDLS N T IP
Sbjct: 660 QLSLDHNNIENLPLQLFLCT------------------------KLHYLDLSYNHLTFIP 695
Query: 193 LAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVL 252
+ + L++ + +N +E LPD + + + L L L +N + L + + NL L L
Sbjct: 696 EEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLEL 755
Query: 253 SNNKLQDIPVCMEEMANLR 271
N L+ +P +E +L+
Sbjct: 756 IGNYLETLPPELEGCQSLK 774
Score = 76.6 bits (187), Expect = 3e-14
Identities = 63/210 (30%), Positives = 99/210 (47%), Gaps = 7/210 (3%)
Query: 82 LNQLQEWQLHRTGL-LKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNK 140
L LQ+ L G L + + + NL L+L + IP I L L EL L N
Sbjct: 560 LPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENN 619
Query: 141 IKTVPKELS--NCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNM 198
+KTV + +S + +L L+L N +I +P ++ L L L L N+ +PL +
Sbjct: 620 LKTVEEIISFQHLQNLSCLKLWHN-NIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLC 678
Query: 199 PALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQ 258
L +LD+ N L +P+ I+ + NL + N I LP + K L L+L N L
Sbjct: 679 TKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLM 738
Query: 259 DIPVCMEEMANLRFVNFRDNPLKLKVSLPP 288
++ + E++NL + N L+ +LPP
Sbjct: 739 NLSPHVGELSNLTHLELIGNYLE---TLPP 765
Score = 47.8 bits (112), Expect = 1e-05
Identities = 62/271 (22%), Positives = 116/271 (42%), Gaps = 65/271 (23%)
Query: 71 EW--KTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLL 128
EW + L S L+K N + +LH L +P+ + + VL L ++P + L
Sbjct: 404 EWTVEKLKSKLVK-NAQDKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQL 462
Query: 129 TRLQE------------------------LILSYNKIKTVPKELSNCASLEKLELAVNRD 164
L+E L L + ++ +P+ + + +L++L L+
Sbjct: 463 VNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSG--- 519
Query: 165 ICDLPQELSNL----------LKLTHLDLSMNDFTTI------------------PLAVL 196
C LP++LS + L+ +L S++ + L VL
Sbjct: 520 -CVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVL 578
Query: 197 N----MPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTIS--NMKNLGTL 250
N M L+ L++ S LE++P +I + NLH L L+ N + + + IS +++NL L
Sbjct: 579 NNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCL 638
Query: 251 VLSNNKLQDIPVCMEEMANLRFVNFRDNPLK 281
L +N + IP + ++NL ++ N ++
Sbjct: 639 KLWHNNIAYIPAQIGALSNLEQLSLDHNNIE 669
Score = 46.2 bits (108), Expect = 4e-05
Identities = 28/104 (26%), Positives = 56/104 (53%), Gaps = 1/104 (0%)
Query: 75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQEL 134
+P + L+ LQ + + + +P+ + + + L L L +N++ + P +G L+ L L
Sbjct: 694 IPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHL 753
Query: 135 ILSYNKIKTVPKELSNCASLEKLELAVNRDICD-LPQELSNLLK 177
L N ++T+P EL C SL++ L V ++ + LP ++ L+
Sbjct: 754 ELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPLPVTERLQ 797
Score = 45.4 bits (106), Expect = 7e-05
Identities = 38/133 (28%), Positives = 57/133 (42%), Gaps = 3/133 (2%)
Query: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPG 124
L ++ + LP L +L L L IPE I NL ++ N I +P G
Sbjct: 661 LSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDG 720
Query: 125 IGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNL--LKLTHLD 182
+ +LQ L+L N + + + ++L LEL + + LP EL LK L
Sbjct: 721 LFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLEL-IGNYLETLPPELEGCQSLKRNCLI 779
Query: 183 LSMNDFTTIPLAV 195
+ N T+PL V
Sbjct: 780 VEENLLNTLPLPV 792
Score = 34.3 bits (77), Expect = 0.16
Identities = 44/170 (25%), Positives = 75/170 (44%), Gaps = 14/170 (8%)
Query: 136 LSYNKIKTVPKELSNCASLEKLELAVNRDICD-----------LPQELSNLLKLTHLDLS 184
+S NK+K + L+N ++EKL+ + ++ D LP + L ++ L L
Sbjct: 391 VSENKLKQI--NLNNEWTVEKLKSKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLE 448
Query: 185 MNDFTTIPLAVLNMPALEWLDM-GSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN 243
+ +P AV + L+ L + S+ + P +NL L L+ E+ +P+ + +
Sbjct: 449 LIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFH 508
Query: 244 MKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEGTD 293
+KNL L LS L + M+ N R LK +S P TD
Sbjct: 509 LKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTD 558
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,664,757
Number of Sequences: 37866
Number of extensions: 554693
Number of successful extensions: 3926
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 125
Number of HSP's successfully gapped in prelim test: 200
Number of HSP's that attempted gapping in prelim test: 2206
Number of HSP's gapped (non-prelim): 955
length of query: 335
length of database: 18,247,518
effective HSP length: 103
effective length of query: 232
effective length of database: 14,347,320
effective search space: 3328578240
effective search space used: 3328578240
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.