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Search of human proteins with 21361891
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21361891 SH2 domain containing 4A [Homo sapiens]
(454 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21361891 SH2 domain containing 4A [Homo sapiens] 913 0.0
gi|224591406 SH2 domain containing 4B isoform 1 [Homo sapiens] 221 8e-58
gi|224591408 SH2 domain containing 4B isoform 2 [Homo sapiens] 155 5e-38
gi|157820785 SH2 domain containing 7 [Homo sapiens] 86 7e-17
gi|14249584 hematopoietic SH2 domain containing [Homo sapiens] 79 6e-15
gi|239787762 SH2 domain protein 2A isoform 4 [Homo sapiens] 60 4e-09
gi|239787758 SH2 domain protein 2A isoform 3 [Homo sapiens] 60 4e-09
gi|239787750 SH2 domain protein 2A isoform 2 [Homo sapiens] 60 4e-09
gi|239787783 SH2 domain protein 2A isoform 2 [Homo sapiens] 60 4e-09
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 57 3e-08
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 55 1e-07
gi|239787752 SH2 domain protein 2A isoform 1 [Homo sapiens] 55 2e-07
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit... 54 4e-07
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 53 5e-07
gi|148746195 trichohyalin [Homo sapiens] 53 5e-07
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 53 7e-07
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 52 1e-06
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 52 1e-06
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 52 1e-06
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 52 1e-06
gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [... 50 4e-06
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 50 6e-06
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 50 6e-06
gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens] 50 6e-06
gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens] 50 6e-06
gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens] 50 6e-06
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 49 1e-05
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 49 1e-05
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 49 1e-05
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 49 1e-05
>gi|21361891 SH2 domain containing 4A [Homo sapiens]
Length = 454
Score = 913 bits (2359), Expect = 0.0
Identities = 454/454 (100%), Positives = 454/454 (100%)
Query: 1 MLKQILSEMYIDPDLLAELSEEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKK 60
MLKQILSEMYIDPDLLAELSEEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKK
Sbjct: 1 MLKQILSEMYIDPDLLAELSEEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKK 60
Query: 61 ENGKSVHWKLGADKEVWVWVMGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHSEE 120
ENGKSVHWKLGADKEVWVWVMGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHSEE
Sbjct: 61 ENGKSVHWKLGADKEVWVWVMGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHSEE 120
Query: 121 FTNSLKTKSQYHDLQAPDNQQTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNI 180
FTNSLKTKSQYHDLQAPDNQQTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNI
Sbjct: 121 FTNSLKTKSQYHDLQAPDNQQTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNI 180
Query: 181 QQMLADSINRMKAYAFHQKKESMKKKQDEEINQIEEERTKQICKSWKEDSEWQASLRKSK 240
QQMLADSINRMKAYAFHQKKESMKKKQDEEINQIEEERTKQICKSWKEDSEWQASLRKSK
Sbjct: 181 QQMLADSINRMKAYAFHQKKESMKKKQDEEINQIEEERTKQICKSWKEDSEWQASLRKSK 240
Query: 241 AADEKRRSLAKQAREDYKRLSLGAQKGRGGERLQSPLRVPQKPERPPLPPKPQFLNSGAY 300
AADEKRRSLAKQAREDYKRLSLGAQKGRGGERLQSPLRVPQKPERPPLPPKPQFLNSGAY
Sbjct: 241 AADEKRRSLAKQAREDYKRLSLGAQKGRGGERLQSPLRVPQKPERPPLPPKPQFLNSGAY 300
Query: 301 PQKPLRNQGVVRTLSSSAQEDIIRWFKEEQLPLRAGYQKTSDTIAPWFHGILTLKKANEL 360
PQKPLRNQGVVRTLSSSAQEDIIRWFKEEQLPLRAGYQKTSDTIAPWFHGILTLKKANEL
Sbjct: 301 PQKPLRNQGVVRTLSSSAQEDIIRWFKEEQLPLRAGYQKTSDTIAPWFHGILTLKKANEL 360
Query: 361 LLSTGMPGSFLIRVSERIKGYALSYLSEDGCKHFLIDASADAYSFLGVDQLQHATLADLV 420
LLSTGMPGSFLIRVSERIKGYALSYLSEDGCKHFLIDASADAYSFLGVDQLQHATLADLV
Sbjct: 361 LLSTGMPGSFLIRVSERIKGYALSYLSEDGCKHFLIDASADAYSFLGVDQLQHATLADLV 420
Query: 421 EYHKEEPITSLGKELLLYPCGQQDQLPDYLELFE 454
EYHKEEPITSLGKELLLYPCGQQDQLPDYLELFE
Sbjct: 421 EYHKEEPITSLGKELLLYPCGQQDQLPDYLELFE 454
>gi|224591406 SH2 domain containing 4B isoform 1 [Homo sapiens]
Length = 357
Score = 221 bits (564), Expect = 8e-58
Identities = 148/371 (39%), Positives = 206/371 (55%), Gaps = 63/371 (16%)
Query: 1 MLKQILSEMYIDPDLLAELSEEQKQILFFKMREEQIRRWKEREA--AMERKESLPVKPRP 58
ML+QIL +MYIDP+LLAELS+ QK ILF+KMREEQ+RRWKERE A+ + E L
Sbjct: 1 MLQQILHDMYIDPELLAELSDVQKHILFYKMREEQLRRWKERETWEALAQDEGLRPPKTK 60
Query: 59 KKENGKSVHWKLGADKEVWVWVMGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHS 118
+ + K + W LGAD EVWVW+MGE DKPY+ + E+IAERARL+A++EAEE +
Sbjct: 61 RAASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQKE 120
Query: 119 EEFTNSLKTKSQYHDLQAPDNQQTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSR 178
E T ++ D A + + +AEK ++E R A + EE+I
Sbjct: 121 AEIT------KKFRDALANEKARI------LAEKWKVEMEDRKAAKVLEERIHE------ 162
Query: 179 NIQQMLADSINRMKAYAFHQKKESMKKKQDEEINQIEEERTKQI----------CK-SWK 227
F +K+E +K+ +E+I EE+R K++ C+ S K
Sbjct: 163 ----------------EFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEK 206
Query: 228 EDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSLGA-QKGRGG-------ERLQSPLRV 279
E+ EW+ LR+SKAADE+R A++AR++Y+ SL A QKG E QS +
Sbjct: 207 EEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQE 266
Query: 280 PQKPERPPLPPKPQFLNSGAYPQKPLRNQGVVRTLSSSAQEDIIRWFKEEQLPLRAGYQK 339
+ P P PQ L A P + R L +++ I+RWFKEEQLP RAG+++
Sbjct: 267 ARLYHHLPDPGLPQPL---ALPVRTWE-----RPLRPVSRDVIVRWFKEEQLPRRAGFER 318
Query: 340 TSDTIAPWFHG 350
+ IAPWFHG
Sbjct: 319 NTKFIAPWFHG 329
>gi|224591408 SH2 domain containing 4B isoform 2 [Homo sapiens]
Length = 309
Score = 155 bits (393), Expect = 5e-38
Identities = 109/309 (35%), Positives = 160/309 (51%), Gaps = 66/309 (21%)
Query: 64 KSVHWKLGADKEVWVWVMGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHSEEFTN 123
K + W LGAD EVWVW+MGE DKPY+ + E+IAERARL+A++EAEE + E T
Sbjct: 17 KHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQKEAEIT- 75
Query: 124 SLKTKSQYHDLQAPDNQQTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQM 183
++ D A + + +AEK ++E R A + EE+I
Sbjct: 76 -----KKFRDALANEKARI------LAEKWKVEMEDRKAAKVLEERIHE----------- 113
Query: 184 LADSINRMKAYAFHQKKESMKKKQDEEINQIEEERTKQI----------CK-SWKEDSEW 232
F +K+E +K+ +E+I EE+R K++ C+ S KE+ EW
Sbjct: 114 -----------EFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREW 162
Query: 233 QASLRKSKAADEKRRSLAKQAREDYKRLSLGA-QKG----------RGGERLQSPLRVPQ 281
+ LR+SKAADE+R A++AR++Y+ SL A QKG G+ + R+
Sbjct: 163 EEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLYH 222
Query: 282 KPERPPLPPKPQFLNSGAYPQKPLRNQGVVRTLSSSAQEDIIRWFKEEQLPLRAGYQKTS 341
P L P+P L ++PLR +++ I+RWFKEEQLP RAG+++ +
Sbjct: 223 HLPDPGL-PQPLALPVSRTWERPLR---------PVSRDVIVRWFKEEQLPRRAGFERNT 272
Query: 342 DTIAPWFHG 350
IAPWFHG
Sbjct: 273 KFIAPWFHG 281
>gi|157820785 SH2 domain containing 7 [Homo sapiens]
Length = 451
Score = 85.9 bits (211), Expect = 7e-17
Identities = 46/122 (37%), Positives = 69/122 (56%), Gaps = 6/122 (4%)
Query: 319 QEDIIRWFKEEQLPLRAGYQKTSDTIAPWFHGILTLKKANELLLSTGMPGSFLIRVSERI 378
QE ++WF E Q P + + + PWFHG +T K+ +LL + GSFLIR+S+R
Sbjct: 27 QELALKWFMETQAP----FILQNGALPPWFHGFITRKQTEQLLRDKAL-GSFLIRLSDRA 81
Query: 379 KGYALSYLSEDGCKHFLIDASADAYSFLGVDQLQHATLADLVEYHKEEPITSLGKELLLY 438
GY LSY D C+HF+I+ + + D H+TLA+LV +++E + KE+L
Sbjct: 82 TGYILSYRGSDRCRHFVINQLRNRRYIISGDTQSHSTLAELVHHYQEAQLEPF-KEMLTA 140
Query: 439 PC 440
C
Sbjct: 141 AC 142
>gi|14249584 hematopoietic SH2 domain containing [Homo sapiens]
Length = 352
Score = 79.3 bits (194), Expect = 6e-15
Identities = 48/130 (36%), Positives = 70/130 (53%), Gaps = 8/130 (6%)
Query: 325 WFKEEQLPLRAGYQKTSDTIAPWFHGILTLKKANELLLSTGMPGSFLIRVSERIKGYALS 384
WF Q+ Q D + WFHG ++ + A LL S + GSFLIRVS GY LS
Sbjct: 17 WFVHTQMG-----QLAQDGVPEWFHGAISREDAENLLESQPL-GSFLIRVSHSHVGYTLS 70
Query: 385 YLSEDGCKHFLIDASADAYSFLGVDQLQHATLADLVEYHKEEPITSLGKELLLYPCGQQD 444
Y ++ C HF++ D + +++ H +L LV +H+++PI +ELL PC Q+D
Sbjct: 71 YKAQSSCCHFMVKLLDDGTFMIPGEKVAHTSLDALVTFHQQKPIEP-RRELLTQPCRQKD 129
Query: 445 QL-PDYLELF 453
DY +LF
Sbjct: 130 PANVDYEDLF 139
>gi|239787762 SH2 domain protein 2A isoform 4 [Homo sapiens]
Length = 361
Score = 60.1 bits (144), Expect = 4e-09
Identities = 42/130 (32%), Positives = 60/130 (46%), Gaps = 9/130 (6%)
Query: 330 QLPLRAGYQKTS-------DTIAPWFHGILTLKKANELLLSTGMPGSFLIRVSERIKGYA 382
Q RA +QKT WFHG +T ++A E LL G +L+R SE +
Sbjct: 43 QAETRAWFQKTQAHWLLQHGAAPAWFHGFITRREA-ERLLEPKPQGCYLVRFSESAVTFV 101
Query: 383 LSYLSEDGCKHFLIDASADAYSFLGVDQLQHATLADLVEYHKEEPITSLGKELLLYPCGQ 442
L+Y S C+HFL+ D + + HA L DL+ ++ P++ G E L P +
Sbjct: 102 LTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYG-ETLTEPLAR 160
Query: 443 QDQLPDYLEL 452
Q P L L
Sbjct: 161 QTPEPAGLSL 170
>gi|239787758 SH2 domain protein 2A isoform 3 [Homo sapiens]
Length = 371
Score = 60.1 bits (144), Expect = 4e-09
Identities = 42/130 (32%), Positives = 60/130 (46%), Gaps = 9/130 (6%)
Query: 330 QLPLRAGYQKTS-------DTIAPWFHGILTLKKANELLLSTGMPGSFLIRVSERIKGYA 382
Q RA +QKT WFHG +T ++A E LL G +L+R SE +
Sbjct: 53 QAETRAWFQKTQAHWLLQHGAAPAWFHGFITRREA-ERLLEPKPQGCYLVRFSESAVTFV 111
Query: 383 LSYLSEDGCKHFLIDASADAYSFLGVDQLQHATLADLVEYHKEEPITSLGKELLLYPCGQ 442
L+Y S C+HFL+ D + + HA L DL+ ++ P++ G E L P +
Sbjct: 112 LTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYG-ETLTEPLAR 170
Query: 443 QDQLPDYLEL 452
Q P L L
Sbjct: 171 QTPEPAGLSL 180
>gi|239787750 SH2 domain protein 2A isoform 2 [Homo sapiens]
Length = 389
Score = 60.1 bits (144), Expect = 4e-09
Identities = 42/130 (32%), Positives = 60/130 (46%), Gaps = 9/130 (6%)
Query: 330 QLPLRAGYQKTS-------DTIAPWFHGILTLKKANELLLSTGMPGSFLIRVSERIKGYA 382
Q RA +QKT WFHG +T ++A E LL G +L+R SE +
Sbjct: 71 QAETRAWFQKTQAHWLLQHGAAPAWFHGFITRREA-ERLLEPKPQGCYLVRFSESAVTFV 129
Query: 383 LSYLSEDGCKHFLIDASADAYSFLGVDQLQHATLADLVEYHKEEPITSLGKELLLYPCGQ 442
L+Y S C+HFL+ D + + HA L DL+ ++ P++ G E L P +
Sbjct: 130 LTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYG-ETLTEPLAR 188
Query: 443 QDQLPDYLEL 452
Q P L L
Sbjct: 189 QTPEPAGLSL 198
>gi|239787783 SH2 domain protein 2A isoform 2 [Homo sapiens]
Length = 389
Score = 60.1 bits (144), Expect = 4e-09
Identities = 42/130 (32%), Positives = 60/130 (46%), Gaps = 9/130 (6%)
Query: 330 QLPLRAGYQKTS-------DTIAPWFHGILTLKKANELLLSTGMPGSFLIRVSERIKGYA 382
Q RA +QKT WFHG +T ++A E LL G +L+R SE +
Sbjct: 71 QAETRAWFQKTQAHWLLQHGAAPAWFHGFITRREA-ERLLEPKPQGCYLVRFSESAVTFV 129
Query: 383 LSYLSEDGCKHFLIDASADAYSFLGVDQLQHATLADLVEYHKEEPITSLGKELLLYPCGQ 442
L+Y S C+HFL+ D + + HA L DL+ ++ P++ G E L P +
Sbjct: 130 LTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYG-ETLTEPLAR 188
Query: 443 QDQLPDYLEL 452
Q P L L
Sbjct: 189 QTPEPAGLSL 198
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 57.0 bits (136), Expect = 3e-08
Identities = 51/255 (20%), Positives = 117/255 (45%), Gaps = 35/255 (13%)
Query: 21 EEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGADKEVWVWV 80
+E+K KMRE++ + W++ E ++++ + W D+E +W
Sbjct: 471 QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKM---------------W----DQEERMWE 511
Query: 81 MGEHHLDKPYDVLCNEIIAERARL-KAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPDN 139
E +K E + E+ ++ + E++ E +KT +E KT Q ++ +
Sbjct: 512 QDERLREK------EERMREQKKMWQQEEKMREEKKTQEQE----KKTWDQEEKMREEER 561
Query: 140 QQTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRM---KAYAF 196
+ ++ KK+ E+EE+ + +EEK+R ++ + + +M + +
Sbjct: 562 MRERE--KKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMW 619
Query: 197 HQKKESMKKKQDEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQARED 256
Q++E ++Q+E + + EE+ +Q K W+++ + + K + +EK + ++ RE
Sbjct: 620 EQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQ 679
Query: 257 YKRLSLGAQKGRGGE 271
+++ +K R E
Sbjct: 680 EEKMQGQEEKMREQE 694
Score = 43.9 bits (102), Expect = 3e-04
Identities = 51/272 (18%), Positives = 115/272 (42%), Gaps = 15/272 (5%)
Query: 30 KMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGADKEVWVWVMGEHHLDKP 89
KM +++ R W++ E E++E + + + ++ K K ++E W E ++
Sbjct: 501 KMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEE 560
Query: 90 YDVLCNEIIAERARLKAEQEA--EEPRKTHSEEFTNSLKTKSQYHDLQAPDNQQTKDIWK 147
+ + E + EQE +E + E+ + + + + + +Q + +W+
Sbjct: 561 RMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWE 620
Query: 148 KVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRMKAYAFHQKKESMKKKQ 207
+ E+E+ Q +EEK++ ++ + + +M+ + + K ++
Sbjct: 621 Q--EEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMRE 678
Query: 208 DEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSLGAQKG 267
EE Q +EE+ ++ + + E + E++ ++ RE +R+ QK
Sbjct: 679 QEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIR--DQK- 735
Query: 268 RGGERLQSPLRVPQKPER---PPLPPKPQFLN 296
E++Q R+P+ ER P LPP N
Sbjct: 736 ---EKMQE--RLPEHEERCSEPCLPPSKVLCN 762
Score = 41.2 bits (95), Expect = 0.002
Identities = 43/210 (20%), Positives = 91/210 (43%), Gaps = 24/210 (11%)
Query: 95 NEIIAERARLKAEQEAEE--------PRKTHSEEF------TNSL-----KTKSQYHDLQ 135
N + E+ RL AE E E RK +F TN+L + + + + +
Sbjct: 189 NAELQEKLRL-AESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQE 247
Query: 136 APDNQQTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRMKAYA 195
+Q + +W++ E E R +EEK+R R ++ L + ++
Sbjct: 248 KKIRKQEEKMWRQEERLREQEGKMRE----QEEKMRRQEKRLREQEKELREQEKELREQK 303
Query: 196 FHQKKESMKKKQDEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQARE 255
+++E ++Q+E++ + EE+ +Q K W+++ ++ + ++K R ++ E
Sbjct: 304 KLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWE 363
Query: 256 DYKRLSLGAQKGRGGERLQSPLRVPQKPER 285
+RL ++ R E++ Q+ ER
Sbjct: 364 QDERLREKEERMREQEKMWEQEEKMQEEER 393
Score = 39.3 bits (90), Expect = 0.007
Identities = 50/255 (19%), Positives = 108/255 (42%), Gaps = 26/255 (10%)
Query: 30 KMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGADKEVWVWVMGEHHLDKP 89
KMRE++ + W++ E E+++ + + + + D+E +W E +K
Sbjct: 325 KMREQEEKMWRQEERLWEQEKQMREQEQKMR------------DQEERMWEQDERLREKE 372
Query: 90 YDVLCNEIIAERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPDN-QQTKDIWK- 147
+ E + E+ E+E R+ E +++ + + Q + +Q + W+
Sbjct: 373 ERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQ 432
Query: 148 --------KVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRMKAYAFHQK 199
K+ E+E++++ +EEKIR ++M R + ++
Sbjct: 433 QRLPEQKEKLWEQEKMQEQEEKIWE-QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQ 491
Query: 200 KESMKKKQDEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKR 259
+E M+ ++ + +Q EER + + +E E +K +EK R K+ +E K+
Sbjct: 492 EEKMRDQEQKMWDQ--EERMWEQDERLREKEERMREQKKMWQQEEKMRE-EKKTQEQEKK 548
Query: 260 LSLGAQKGRGGERLQ 274
+K R ER++
Sbjct: 549 TWDQEEKMREEERMR 563
Score = 37.7 bits (86), Expect = 0.022
Identities = 41/223 (18%), Positives = 90/223 (40%), Gaps = 32/223 (14%)
Query: 95 NEIIAERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDL--------QAPDNQQTKDIW 146
N I E + K + E+ R SE+ L K L Q N +++W
Sbjct: 178 NTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMW 237
Query: 147 KKVAEKEELEQGSRPAPTL---EEEKIRSLSSSSRNIQQMLADSINRMKAYAFH---QKK 200
++ E E E+ R +EE++R R ++ + R++ Q+K
Sbjct: 238 RQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEK 297
Query: 201 ESMKKK------------------QDEEINQIEEERTKQICKSWKEDSEWQASLRKSKAA 242
E ++K Q+E++ + EE+ +Q + W+++ + + +K +
Sbjct: 298 ELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQ 357
Query: 243 DEKRRSLAKQAREDYKRLSLGAQKGRGGERLQSPLRVPQKPER 285
+E+ ++ RE +R+ + E++Q R+ ++ ++
Sbjct: 358 EERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKK 400
Score = 32.7 bits (73), Expect = 0.70
Identities = 34/224 (15%), Positives = 92/224 (41%), Gaps = 16/224 (7%)
Query: 18 ELSEEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGADKEVW 77
EL E++K K+R+++ + W++ E E++ + + + K + + +E
Sbjct: 242 ELREQEK-----KIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQE 296
Query: 78 VWVMGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAP 137
+ + L + + + + E + E++ E + + + + Q + +
Sbjct: 297 KELREQKKLREQEEQMQEQ---EEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQK 353
Query: 138 DNQQTKDIWKKVAEKEELEQGSRPAPTL--------EEEKIRSLSSSSRNIQQMLADSIN 189
Q + +W++ E E+ R + EEE+IR R ++ + +
Sbjct: 354 MRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEE 413
Query: 190 RMKAYAFHQKKESMKKKQDEEINQIEEERTKQICKSWKEDSEWQ 233
+M+ + ++ K+ Q + + + +E+ +Q +E+ W+
Sbjct: 414 KMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWE 457
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 55.5 bits (132), Expect = 1e-07
Identities = 61/250 (24%), Positives = 114/250 (45%), Gaps = 36/250 (14%)
Query: 21 EEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGADKEVWVWV 80
+E+K+ K+RE++ R+ E+EA M R+E K R ++E + +K++W
Sbjct: 409 QEEKRQEEEKIREQEKRQ--EQEAKMWRQEE---KIREQEEKIRE------QEKKMWRQE 457
Query: 81 MGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPDNQ 140
H +K I E R + E+ + K H +E + K + H+ + +
Sbjct: 458 EKIHEQEK--------IREEEKRQEQEEMWRQEEKIHEQE--EIWRQKEKMHEQEEKIRK 507
Query: 141 QTKDIWK---KVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQM-----LADSINRM- 191
Q + +W+ K+ E+EE + +EEKIR R ++M + + R
Sbjct: 508 QEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQE 567
Query: 192 ---KAYAFHQKKESMKKK---QDEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEK 245
K + +K ++K Q+E+I + EE+R +Q K WK++ + + K + +EK
Sbjct: 568 QEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEK 627
Query: 246 RRSLAKQARE 255
R ++ RE
Sbjct: 628 IREQEEKIRE 637
Score = 52.0 bits (123), Expect = 1e-06
Identities = 57/287 (19%), Positives = 120/287 (41%), Gaps = 35/287 (12%)
Query: 3 KQILSEMYIDPDLLAELSEEQKQILFFKMREEQIRR-----WKEREAAMERKESLPVKPR 57
+Q EM+ + + E E +Q +EE+IR+ W++ E E++E + R
Sbjct: 472 RQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKI----R 527
Query: 58 PKKENGKSVHWKLGADKEVWVWVMGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTH 117
++E K+ +E+W H +K ++ E R + E + +
Sbjct: 528 EQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWE--------EEKRQEQEDKMWRQEEKI 579
Query: 118 SEEFTNSLKTKSQYHDLQAPDNQQTKDIWK---KVAEKEELEQGSRPAPTLEEEKIRSLS 174
E+ + + + + + +Q + +WK K+ E+EE Q +EEKIR
Sbjct: 580 REQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQE 639
Query: 175 SSSRNIQQMLADSINRM--KAYAFHQKKESMKKK-------------QDEEINQIEEERT 219
++ ++ + + +M + +++E+M ++ Q+E+I + EE
Sbjct: 640 EMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQ 699
Query: 220 KQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSLGAQK 266
+Q K W+++ + K + +EK R ++ E RL +K
Sbjct: 700 EQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 746
Score = 45.1 bits (105), Expect = 1e-04
Identities = 45/192 (23%), Positives = 84/192 (43%), Gaps = 20/192 (10%)
Query: 100 ERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPDN--------QQTKDIWK---K 148
ERA+L Q+ + H + S+ K Q Q +N QQ + +W+ K
Sbjct: 252 ERAKLLLPQQQLQAEADHLGKELQSVSAKLQ---AQVEENELWNRLNQQQEEKMWRQEEK 308
Query: 149 VAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRMKAY-AFHQKKESMKKKQ 207
+ E EE Q +EEKIR R ++M+ + +M+ +KE ++Q
Sbjct: 309 IQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ 368
Query: 208 DEEINQIEEERTKQICKSWKEDSEWQASLRKSKAAD-----EKRRSLAKQAREDYKRLSL 262
+E + + EE+ +Q W+++ + + K + E++R ++ RE KR
Sbjct: 369 EEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 428
Query: 263 GAQKGRGGERLQ 274
A+ R E+++
Sbjct: 429 EAKMWRQEEKIR 440
Score = 43.1 bits (100), Expect = 5e-04
Identities = 47/245 (19%), Positives = 106/245 (43%), Gaps = 9/245 (3%)
Query: 30 KMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGADKEVWVWVMGEHHLDKP 89
K+RE++ + W++ E E+++ + R ++E K+ +E+W H ++
Sbjct: 445 KIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEK 504
Query: 90 YDVLCNEIIAERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPDNQQTKD-IWKK 148
+ E R K ++ E+ R+ + + K + Q + + ++ IW++
Sbjct: 505 --IRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEE 562
Query: 149 VAEKEELEQGSRPAPTLEEEKIRSLSSSS-RNIQQMLADSINRMKAYAFHQKKESMKKKQ 207
+E+ ++ R +EEKIR R +++ R + K+E ++Q
Sbjct: 563 EKRQEQEDKMWR-----QEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQ 617
Query: 208 DEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSLGAQKG 267
+E+I + EE+ +Q K +++ Q K +EK ++ +E + + +K
Sbjct: 618 EEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKI 677
Query: 268 RGGER 272
R E+
Sbjct: 678 REQEK 682
Score = 38.9 bits (89), Expect = 0.010
Identities = 47/249 (18%), Positives = 107/249 (42%), Gaps = 23/249 (9%)
Query: 14 DLLAELSEEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGAD 73
+L L+++Q++ ++ +EE+I+ W+E+ E K R ++E + K+
Sbjct: 289 ELWNRLNQQQEEKMW--RQEEKIQEWEEKIQEQEEKI------REQEEKIREQEEKMRRQ 340
Query: 74 KEVWVWVMGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHSEEFTNS----LKTKS 129
+E+ +W E + + +++ + R + + E EE + E + +
Sbjct: 341 EEM-MWEK-EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE 398
Query: 130 QYHDLQAPDNQQTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSIN 189
+ H+ + Q+ K ++ ++E Q +EEKIR R ++
Sbjct: 399 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEK------- 451
Query: 190 RMKAYAFHQKKESMKKKQDEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSL 249
K + +K +K ++EE Q +EE +Q K +++ W+ + + ++ R+
Sbjct: 452 --KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQE 509
Query: 250 AKQAREDYK 258
K R++ K
Sbjct: 510 EKVWRQEEK 518
>gi|239787752 SH2 domain protein 2A isoform 1 [Homo sapiens]
Length = 399
Score = 54.7 bits (130), Expect = 2e-07
Identities = 41/139 (29%), Positives = 59/139 (42%), Gaps = 17/139 (12%)
Query: 330 QLPLRAGYQKTS-------DTIAPWFHGILTLK---------KANELLLSTGMPGSFLIR 373
Q RA +QKT WFHG +T + + E LL G +L+R
Sbjct: 71 QAETRAWFQKTQAHWLLQHGAAPAWFHGFITRRVRPPLSVTHREAERLLEPKPQGCYLVR 130
Query: 374 VSERIKGYALSYLSEDGCKHFLIDASADAYSFLGVDQLQHATLADLVEYHKEEPITSLGK 433
SE + L+Y S C+HFL+ D + + HA L DL+ ++ P++ G
Sbjct: 131 FSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYG- 189
Query: 434 ELLLYPCGQQDQLPDYLEL 452
E L P +Q P L L
Sbjct: 190 ETLTEPLARQTPEPAGLSL 208
>gi|158631203 dual adaptor of phosphotyrosine and
3-phosphoinositides [Homo sapiens]
Length = 280
Score = 53.5 bits (127), Expect = 4e-07
Identities = 30/83 (36%), Positives = 49/83 (59%), Gaps = 4/83 (4%)
Query: 347 WFHGILTLKKANELLLSTGMPGSFLIRVSERIKG-YALSYLSEDGCKHFLIDASADAYSF 405
W+HG LT A LLLS G GS+L+R S G Y+LS ++D KHF ++ + ++ F
Sbjct: 35 WYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTGYSFKF 94
Query: 406 LGVDQLQHATLADLVEYHKEEPI 428
G ++ ++L D V++ +P+
Sbjct: 95 -GFNEF--SSLKDFVKHFANQPL 114
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 53.1 bits (126), Expect = 5e-07
Identities = 53/264 (20%), Positives = 116/264 (43%), Gaps = 19/264 (7%)
Query: 21 EEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGADK---EVW 77
EE+ Q K+RE++ + +E+E M R+E + + K + + W+ E
Sbjct: 313 EEKIQEQEEKIREQE-EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEM 371
Query: 78 VWVMGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAP 137
+W E + + E I E+ + E+E ++ E+ + + + + +
Sbjct: 372 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 431
Query: 138 DNQQTKDIWK---KVAEKEELEQGSRPAPTLE----EEKIRSLSSSSRNIQQMLADSINR 190
+Q K +W+ K+ E+E++ + + E EEKIR R ++M R
Sbjct: 432 IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIR 491
Query: 191 MKAYAFHQKKESMKKKQDEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLA 250
K+E +Q+E+++ EE+ +Q K W+++ + + K + +EK R
Sbjct: 492 --------KQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQE 543
Query: 251 KQAREDYKRLSLGAQKGRGGERLQ 274
+ +E +++ +K + E+++
Sbjct: 544 EMMQEQEEKMGEQEEKMQEQEKMR 567
Score = 52.4 bits (124), Expect = 8e-07
Identities = 46/267 (17%), Positives = 120/267 (44%), Gaps = 13/267 (4%)
Query: 21 EEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGADKEVWVWV 80
EE+K K +E++ + W++ E E++E + + + + +H + +E
Sbjct: 401 EEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREE----- 455
Query: 81 MGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPDNQ 140
E ++ E I E+ + ++E ++ ++ + + + HD + +
Sbjct: 456 --EKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIRE 513
Query: 141 QTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRMKAYAFHQKK 200
Q + +W++ + E E+ R +EEKIR + ++ + + +M+ +++
Sbjct: 514 QEEKMWRQEEKIREQEEKIRE----QEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQ 569
Query: 201 ESMKKKQDEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRL 260
E ++Q+E+I + +E+ +Q K W+++ + + + +EK ++ E +++
Sbjct: 570 EEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKM 629
Query: 261 SLGAQKGRGGER--LQSPLRVPQKPER 285
+K R E + +R+ Q+ E+
Sbjct: 630 QEQEEKMRRQEEKMWEQEVRLRQQEEK 656
Score = 44.7 bits (104), Expect = 2e-04
Identities = 45/217 (20%), Positives = 94/217 (43%), Gaps = 18/217 (8%)
Query: 18 ELSEEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGADKEVW 77
E EQ++I + R+EQ W++ E E++E K + ++ K+ +E
Sbjct: 444 EKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQE------KIRKQEEK- 496
Query: 78 VWVMGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRK-----THSEEFTNSLKTKSQYH 132
VW E D+ + E R K ++ E+ R+ EE + K
Sbjct: 497 VWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQ 556
Query: 133 DLQAPDNQQTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRMK 192
+ + + ++ + +K+ E+EE + + +EEKI R ++M+ + +M
Sbjct: 557 EEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKM- 615
Query: 193 AYAFHQKKESMKKKQDEEINQIEEERTKQICKSWKED 229
++E +Q+E++ + EE+ +Q K W+++
Sbjct: 616 -----WEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 647
Score = 44.3 bits (103), Expect = 2e-04
Identities = 46/189 (24%), Positives = 87/189 (46%), Gaps = 28/189 (14%)
Query: 100 ERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPDN--------QQTKDIWK---K 148
ERA+L Q+ + H + S+ K Q Q +N QQ + +W+ K
Sbjct: 252 ERAKLLLPQQQLQAEADHLGKELQSVSAKLQ---AQVEENELWNRLNQQQEEKMWRQEEK 308
Query: 149 VAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRMKAYAFHQKKESMKKKQD 208
+ E EE Q +EEKIR R ++M+ + +M+ ++E M +++
Sbjct: 309 IQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMR------RQEEMMWEKE 362
Query: 209 EEINQIEE---ERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSLGAQ 265
E++ ++EE E+ ++I + +E Q +R+ E++R ++ RE KR A+
Sbjct: 363 EKMRRLEEMMWEKEEKI-RELEEKMHEQEKIRE----QEEKRQEEEKIREQEKRQEQEAK 417
Query: 266 KGRGGERLQ 274
R E+++
Sbjct: 418 MWRQEEKIR 426
Score = 42.0 bits (97), Expect = 0.001
Identities = 47/236 (19%), Positives = 103/236 (43%), Gaps = 21/236 (8%)
Query: 40 KEREAAMERKESLPVKPRPKKE-NGKSVHWKLGADKEVWVWVMGEHHLDKPYDVLCNEII 98
KE+ A ++ K L + + + N K + KL K ++ + L D L E+
Sbjct: 220 KEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAK----LLLPQQQLQAEADHLGKELQ 275
Query: 99 AERARLKAEQEAEEP----RKTHSEEFTNSLKTKSQYHDLQAPDNQQTKDIWKKVAEKEE 154
+ A+L+A+ E E + E+ + ++ + ++ ++ +K+ E+EE
Sbjct: 276 SVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEE 335
Query: 155 LEQGSRPAPTLEEEKIR-------SLSSSSRNIQQML---ADSINRMKAYAFHQKK--ES 202
+ +EEK+R R +++M+ + I ++ Q+K E
Sbjct: 336 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQ 395
Query: 203 MKKKQDEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYK 258
+K+Q+EE + +E+R +Q K W+++ + + K + ++K ++ E K
Sbjct: 396 EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEK 451
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 53.1 bits (126), Expect = 5e-07
Identities = 57/267 (21%), Positives = 114/267 (42%), Gaps = 30/267 (11%)
Query: 21 EEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGADKEVWVWV 80
E++++ K +E+ R W +RE ER E K + K++ + +E W+ +
Sbjct: 439 EQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEE-------RRERWLKL 491
Query: 81 MGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPDNQ 140
E ++ E ++ R + E+ E+ K EE + +S+ L+ +
Sbjct: 492 EEEERREQ------QERREQQLRREQEERREQRLKRQEEEERLQQRLRSE-QQLRREQEE 544
Query: 141 QTKDIWKKVAEKE----------ELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINR 190
+ + + K+ EK + EQ R L+ E+ R R ++ L + R
Sbjct: 545 RREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKR 604
Query: 191 MKAYAFHQKKESMKKKQDEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLA 250
+ Q++ ++ + EE EEER +Q+ KS +++ Q LR+ + ++RR
Sbjct: 605 EEVERLEQEERREQRLKREEP---EEERRQQLLKSEEQEERRQQQLRREQ---QERREQR 658
Query: 251 KQAREDYKRLSLGAQKGRGGERLQSPL 277
+ E+ +RL ++ ER + L
Sbjct: 659 LKREEEEERLEQRLKREHEEERREQEL 685
Score = 50.8 bits (120), Expect = 2e-06
Identities = 53/254 (20%), Positives = 108/254 (42%), Gaps = 22/254 (8%)
Query: 21 EEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGADKEVWVWV 80
E +K++ F + EEQ++R + + E ++ L ++ + K W W
Sbjct: 826 EREKELQFLE-EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQK-------WRWQ 877
Query: 81 MGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPDNQ 140
+ E + + + + E+ R + + EE + EE K + Q + Q + +
Sbjct: 878 LEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREERE---KRRRQEQERQYREEE 934
Query: 141 QTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRMKAYAFHQKK 200
Q + +++ +EE E+ R + K + L +Q+L + + + ++
Sbjct: 935 QLQQEEEQLL-REEREKRRRQERERQYRKDKKLQQKE---EQLLGEEPEKRR------RQ 984
Query: 201 ESMKKKQDEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRL 260
E KK ++EE Q EEE+ + + + EW+ RK ++ L ++ RE +RL
Sbjct: 985 EREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREK-RRL 1043
Query: 261 SLGAQKGRGGERLQ 274
++ R E LQ
Sbjct: 1044 QERERQYREEEELQ 1057
Score = 47.8 bits (112), Expect = 2e-05
Identities = 66/321 (20%), Positives = 136/321 (42%), Gaps = 57/321 (17%)
Query: 32 REEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGADKEVWVWVMGEHHLDKPYD 91
R+EQ R E E E++E L + R +++ +L ++ W
Sbjct: 141 RQEQERELAEGEEQSEKQERLEQRDRQRRDE------ELWRQRQEW-------------- 180
Query: 92 VLCNEIIAERARLKAEQEAEEPRKTH-SEEFTNSLKTKSQY-----HDLQAPDNQQTKDI 145
ER +AE+E + K H +EEF + + + + + QQ ++
Sbjct: 181 -------QEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRER 233
Query: 146 WKKVAEKEELEQGSRPAPTL--EEEKI--------RSLSSSSRNIQQMLADSINRMKAYA 195
+V ++EE ++ + L EEEK+ R L ++++ + R +
Sbjct: 234 QDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEE 293
Query: 196 FHQ-----KKESMKKKQDEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLA 250
Q +++ +++KQ+EE + +EER +Q + +++ + LR+ + E+RR
Sbjct: 294 EQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQ---EERREQQ 350
Query: 251 KQAREDYKRLSLGAQKGRGGERLQSPLRVPQKPERPPLPPKPQFLNSGAYPQKPLRNQGV 310
+ ++ +R ++ + ER + LR Q+ R + Q L ++ LR +
Sbjct: 351 LRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRR----EQQLRREQQ 406
Query: 311 VRTLSSSAQEDIIRWFKEEQL 331
+R +E +R +E+QL
Sbjct: 407 LRREQQLRREQQLR--REQQL 425
Score = 44.3 bits (103), Expect = 2e-04
Identities = 51/271 (18%), Positives = 115/271 (42%), Gaps = 19/271 (7%)
Query: 18 ELSEEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGADKEVW 77
EL +E++Q+L E + RR +ERE +E L + + + +++
Sbjct: 1025 ELQQEEEQLL---REEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQY- 1080
Query: 78 VWVMGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAP 137
E L + + L E +R R + E++ E + EE L + +
Sbjct: 1081 ---RKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEE--EQLLREER------- 1128
Query: 138 DNQQTKDIWKKVAEKEELEQGSRPAPTLEEEKIR--SLSSSSRNIQQMLADSINRMKAYA 195
+ ++ +++ ++ E+EE++Q E EK R L R +++ + ++
Sbjct: 1129 EKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQ 1188
Query: 196 FHQKKESMKKKQDEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQARE 255
+++E ++ ++EE Q ++ + + + + D +WQ K A + + + E
Sbjct: 1189 EKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENE 1248
Query: 256 DYKRLSLGAQKGRGGER-LQSPLRVPQKPER 285
+++L + R ++ LQ L Q+ +R
Sbjct: 1249 QFRQLEDSQLRDRQSQQDLQHLLGEQQERDR 1279
Score = 43.1 bits (100), Expect = 5e-04
Identities = 53/285 (18%), Positives = 120/285 (42%), Gaps = 13/285 (4%)
Query: 3 KQILSEMYIDPDLLAELSEEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKKEN 62
+Q L D L E + ++Q ++R ++ R+++E E ++ E ++ + +
Sbjct: 1633 EQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRK 1692
Query: 63 GKSVHWKLGADKEVWVWVMGEHHLDKPYDVLCNEIIAERARLKAEQEA----EEPRKTHS 118
+ +L + ++ E L + ++ E+ R + EQE E RK
Sbjct: 1693 FREEEQQLRRQERERKFLQEEQQLRRQ-ELERKFREEEQLRQETEQEQLRRQERYRKILE 1751
Query: 119 EEFTNSLKTKSQYHDLQAPDNQQTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSR 178
EE + + Q + + ++ ++ E+++L EEE++R +
Sbjct: 1752 EEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQ-EREEQ 1810
Query: 179 NIQQMLADSINRMKAYAFHQKKESMKKKQDEEINQIEEERTKQICKSWKEDSE-WQASLR 237
++ D R + +++ + +Q+ + EE+ KS +E+ E WQ +
Sbjct: 1811 QLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQ 1870
Query: 238 KSKAADEKR---RSLAKQAREDYKRLSLG---AQKGRGGERLQSP 276
K + E++ + +Q +E+ + +G +Q+G+G RL P
Sbjct: 1871 KRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEP 1915
Score = 42.0 bits (97), Expect = 0.001
Identities = 55/293 (18%), Positives = 114/293 (38%), Gaps = 23/293 (7%)
Query: 21 EEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGADKEVWVWV 80
EE ++ + EEQ+R+ + +E ER+E + R ++E + + K ++
Sbjct: 263 EEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRRE--QQLRRKQEEERREQQEE 320
Query: 81 MGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPDNQ 140
E + E ++ R + E+ E+ + EE + + + + +
Sbjct: 321 RREQQERREQQ---EERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQL 377
Query: 141 QTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRMKAYAFHQKK 200
+ + ++ + +Q R E+++R R Q + R + H++K
Sbjct: 378 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQK 437
Query: 201 ESMKK----------------KQDEEINQIEEERTKQICKSWKEDS--EWQASLRKSKAA 242
++ K++EE + E+ER KQ K +E+ E L + +
Sbjct: 438 HEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERR 497
Query: 243 DEKRRSLAKQAREDYKRLSLGAQKGRGGERLQSPLRVPQKPERPPLPPKPQFL 295
+++ R + RE +R ++ ERLQ LR Q+ R + Q L
Sbjct: 498 EQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLL 550
Score = 42.0 bits (97), Expect = 0.001
Identities = 50/243 (20%), Positives = 99/243 (40%), Gaps = 48/243 (19%)
Query: 20 SEEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGADKEVWVW 79
SE+Q + + RE+ ++R +E+ ER+E R K+E
Sbjct: 534 SEQQLRREQEERREQLLKREEEKRLEQERREQ-----RLKREQ----------------- 571
Query: 80 VMGEHHLDKPYDVLCNEIIAERARLKAEQE--AEEPRKTHSEEFTNSLKTKSQYHDLQAP 137
E D+ +L E + RLK EQE E+ K E + + Q + P
Sbjct: 572 ---EERRDQ---LLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEP 625
Query: 138 DNQQTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRMKAYAFH 197
+ ++ + + K ++E +Q R E+ ++Q L
Sbjct: 626 EEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRL------------- 672
Query: 198 QKKESMKKKQDEEINQIEEERTKQICKS----WKEDSEWQASLRKSKAADEKRRSLAKQA 253
K+E ++++++E+ + E+E+ ++ KS W+ E +A R+SK R+ ++
Sbjct: 673 -KREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRR 731
Query: 254 RED 256
R++
Sbjct: 732 RQE 734
Score = 40.8 bits (94), Expect = 0.003
Identities = 58/280 (20%), Positives = 120/280 (42%), Gaps = 48/280 (17%)
Query: 18 ELSEEQKQILFFKMREEQIRRWKEREAAMERKESL--------PVKPRPKKENGKSVHWK 69
E EE++Q L +E+ R+ + R ER+E ++ R K+E+ + +
Sbjct: 624 EPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQ 683
Query: 70 LGADKE-------------VWVWVMGEHHLDKPYDVLCNEIIAERARLKAE---QEAEEP 113
A++E W W L+ D +++ + + + + QE EE
Sbjct: 684 ELAEEEQEQARERIKSRIPKWQW-----QLESEADARQSKVYSRPRKQEGQRRRQEQEEK 738
Query: 114 RKTHSEEFTNSLKTKSQYHDLQAPDNQQTKDIWKKVAEKEELEQGSR---PAPTLEEEKI 170
R+ E + + + H Q + Q+ W+ AE E+ E+G + P L E++
Sbjct: 739 RRRRESEL--QWQEEERAHRQQQEEEQRRDFTWQWQAE-EKSERGRQRLSARPPLREQRE 795
Query: 171 RSLSSSSR--NIQQMLADSINRMKAYAFHQKKESMKKKQDEEINQIEEERTKQICKSWKE 228
R L + R Q+ L + + +++ ++++++E+ +EEE Q + ++
Sbjct: 796 RQLRAEERQQREQRFLPEEEEK-------EQRRRQRREREKELQFLEEEEQLQRRERAQQ 848
Query: 229 DSEWQASLRKSKAADEKRRSLAKQAREDYKRLSLGAQKGR 268
E + L++ D++RR +Q R+ R L ++ R
Sbjct: 849 LQEEEDGLQE----DQERRRSQEQRRDQKWRWQLEEERKR 884
Score = 39.3 bits (90), Expect = 0.007
Identities = 56/325 (17%), Positives = 137/325 (42%), Gaps = 30/325 (9%)
Query: 32 REEQIRRWKEREAAMERKESLPVKPRPKKENG-------------KSVHWKLGADKEVWV 78
+EE+ + W++RE + ++E + P+++ + + + +++
Sbjct: 239 QEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQ 298
Query: 79 WVMGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPD 138
+ E L + + E ER + +E +E R+ + + Q Q +
Sbjct: 299 RLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEE 358
Query: 139 NQQTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRMKAYAFHQ 198
++ + ++ E+E EQ R L E+ R QQ+ + R + +
Sbjct: 359 RREQQ--LRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 416
Query: 199 ----KKESMKKKQDEEINQI---EEERTKQICKSWKEDSEW-QASLRKSKAADEKRRSLA 250
+++ ++++Q+EE ++ +E R +++ + +E +W + + E+R+
Sbjct: 417 QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQL 476
Query: 251 KQAREDYKR---LSLGAQKGR-GGERLQSPLRVPQKPERPPLPPKPQFLNSGAYPQKPLR 306
K+ +E+ +R L L ++ R ER + LR Q+ R + + Q+ LR
Sbjct: 477 KRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQE---EEERLQQRLR 533
Query: 307 NQGVVRTLSSSAQEDIIRWFKEEQL 331
++ +R +E +++ +E++L
Sbjct: 534 SEQQLRREQEERREQLLKREEEKRL 558
Score = 38.9 bits (89), Expect = 0.010
Identities = 74/358 (20%), Positives = 146/358 (40%), Gaps = 40/358 (11%)
Query: 8 EMYIDPDLLAELSEEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVH 67
E + D + EE++Q+ R+E+ R+++E E + R+E +++ + H
Sbjct: 1405 EQQLRQDRDRKFREEEQQL----SRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERH 1460
Query: 68 WKLGADKEVWVWVMGE--HHLDKPYDVLCNEIIA---ERARLKAEQEA----------EE 112
K ++++ + H ++ L E ER R EQE EE
Sbjct: 1461 RKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEE 1520
Query: 113 PRKTHSEEFTNSLKTKSQYHDLQAPDNQQTKDIWKKVAEKEELEQGSRPAPT-------- 164
++ H ++ + Q Q Q+ +D +K E+E+L Q
Sbjct: 1521 EQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRK 1580
Query: 165 --LEEEKIRSLSSSSRNIQQMLADSINRMKAYAFHQKKESMKKKQDEEINQIEEERTKQI 222
LEE+K+R + ++ + R + +++ K ++DE++ Q EE+
Sbjct: 1581 FRLEEQKVRRQEQERKFMED--EQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHR 1638
Query: 223 CKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSLG-AQKGRGGERLQSPLRVPQ 281
+ ++ E + LR+ + + R ++ RE+ + L G Q+ R ER + Q
Sbjct: 1639 QERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQ 1698
Query: 282 KPERPPLPPKPQFLNSGAYPQKPLRNQGVVRTLSSSAQEDIIRWFKEEQLPLRAGYQK 339
+ R K FL ++ LR Q + R +E + + ++EQL + Y+K
Sbjct: 1699 QLRRQERERK--FLQE----EQQLRRQELERKFRE--EEQLRQETEQEQLRRQERYRK 1748
Score = 37.7 bits (86), Expect = 0.022
Identities = 63/323 (19%), Positives = 134/323 (41%), Gaps = 33/323 (10%)
Query: 14 DLLAELSEEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGAD 73
DL L E+Q+ + RE++ RRW++R+ +E L R +++ K K +
Sbjct: 1266 DLQHLLGEQQE-----RDREQERRRWQQRDRHFPEEEQL---EREEQKEAKRRDRKSQEE 1317
Query: 74 KEVWVWVMGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHD 133
K+ +L E +R R + +++ E + E L+ + +
Sbjct: 1318 KQ----------------LLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRK 1361
Query: 134 LQAPDNQQTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRMKA 193
+ + + + K + E++ L + R L+EE+ + ++Q +
Sbjct: 1362 FREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQ 1421
Query: 194 YAFHQKKESMKKKQDEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQA 253
Q+++ +++++++ + E ER K + + + E R+ + ++R
Sbjct: 1422 QLSRQERDRKFREEEQQVRRQERER-KFLEEEQQLRQERHRKFREEEQLLQEREEQQLHR 1480
Query: 254 REDYKRLSLGAQKGRGGER----LQSPLRVPQKPERPPLPPKPQFLNSGAYPQKPLRNQG 309
+E ++ Q+ R ER + LR Q+PER L + Q L+ +K L+ +
Sbjct: 1481 QERDRKFLEEEQQLRRQERDRKFREQELR-SQEPERKFLEEEQQ-LHRQQRQRKFLQEEQ 1538
Query: 310 VVRTLSSSAQ--EDIIRWFKEEQ 330
+R Q +D R F+EE+
Sbjct: 1539 QLRRQERGQQRRQDRDRKFREEE 1561
Score = 36.6 bits (83), Expect = 0.048
Identities = 62/305 (20%), Positives = 118/305 (38%), Gaps = 60/305 (19%)
Query: 1 MLKQILSEMYIDPDLLAELSEEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKK 60
+LK E L E E ++Q L + EE++ + +RE ER+E +
Sbjct: 633 LLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQ-----ELAE 687
Query: 61 ENGKSVHWKLGADKEVWVWVMGEHHLDKPYDVLCNEIIAERARLKAE---QEAEEPRKTH 117
E + ++ + W W L+ D +++ + + + + QE EE R+
Sbjct: 688 EEQEQARERIKSRIPKWQW-----QLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRR 742
Query: 118 SEEFTNSLKTKSQYHDLQAPDNQQTKDIWKKVAEKEELEQGSR---PAPTLEEEKIRSLS 174
E + + + H Q + Q+ W+ AE E+ E+G + P L E++ R L
Sbjct: 743 ESEL--QWQEEERAHRQQQEEEQRRDFTWQWQAE-EKSERGRQRLSARPPLREQRERQLR 799
Query: 175 SSSRNI------------QQMLADSINRMKAYAFHQKKESMKKKQ--------------D 208
+ R +Q R K F +++E +++++ D
Sbjct: 800 AEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQED 859
Query: 209 EEINQIEEERTKQICKSWKEDSE-------------WQASLRK-SKAADEKRRSLAKQAR 254
+E + +E+R Q + W+ + E Q LRK + E+ L ++ R
Sbjct: 860 QERRRSQEQRRDQKWR-WQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREER 918
Query: 255 EDYKR 259
E +R
Sbjct: 919 EKRRR 923
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 52.8 bits (125), Expect = 7e-07
Identities = 47/252 (18%), Positives = 107/252 (42%), Gaps = 46/252 (18%)
Query: 30 KMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGADKEVWVWVMGEHHLDKP 89
K+RE++ + W++ E E+++ + R ++E K+ +E+W
Sbjct: 492 KIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIW------------ 539
Query: 90 YDVLCNEIIAERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPDNQQTKDIWKKV 149
R + K ++ E+ RK + + + + + HD + +Q + +W++
Sbjct: 540 -----------RQKEKIHEQEEKIRKQEEKMW----RQEEKMHDQEEKIREQEEKVWRQE 584
Query: 150 AEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRM--KAYAFHQKKESMKKK- 206
+ E E+ R +EEKIR ++ ++ + + +M + +++E M+++
Sbjct: 585 EKIREQEEKIRE----QEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQE 640
Query: 207 ------------QDEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAR 254
Q+E+I + EE +Q K W+++ + K + +EK R ++
Sbjct: 641 EKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMW 700
Query: 255 EDYKRLSLGAQK 266
E RL +K
Sbjct: 701 EQEVRLRQQEEK 712
Score = 50.4 bits (119), Expect = 3e-06
Identities = 50/262 (19%), Positives = 116/262 (44%), Gaps = 30/262 (11%)
Query: 21 EEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGAD---KEVW 77
EE+ Q K+RE++ + +E+E M R+E + + K + + W+ +E
Sbjct: 374 EEKIQEQEEKIREQE-EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEM 432
Query: 78 VWVMGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAP 137
+W E + + E I E+ + E+E ++ E+ + + + + +
Sbjct: 433 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 492
Query: 138 DNQQTKDIWK---KVAEKEELEQGSRPAPTLE----EEKIRSLSSSSRNIQQMLADSINR 190
+Q + +W+ K+ E+E++ + + E EEKIR R +++
Sbjct: 493 IREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKI------- 545
Query: 191 MKAYAFHQKKESMKK------KQDEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADE 244
H+++E ++K +Q+E+++ EE+ +Q K W+++ + + K + +E
Sbjct: 546 ------HEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEE 599
Query: 245 KRRSLAKQAREDYKRLSLGAQK 266
K R + +E +++ +K
Sbjct: 600 KIREQEEMTQEQEEKMGEQEEK 621
Score = 47.4 bits (111), Expect = 3e-05
Identities = 48/255 (18%), Positives = 108/255 (42%), Gaps = 27/255 (10%)
Query: 30 KMREEQIRRW------KEREAAMERKESLPVKPRPKKENGKSVHWKLGADKEVWVWVMGE 83
KMR ++ W +E E M +E + + ++E K + ++E +W E
Sbjct: 425 KMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE 484
Query: 84 HHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDL--QAPDNQQ 141
++ E+ R + E+ + K H +E + + + ++ Q ++
Sbjct: 485 KIREQE----------EKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIRE 534
Query: 142 TKDIWK---KVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRMKAYAFHQ 198
++IW+ K+ E+EE + +EEK+ R ++ + +++
Sbjct: 535 QEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIR------ 588
Query: 199 KKESMKKKQDEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYK 258
++E ++Q+E+I + EE +Q K +++ + K + +EK R ++ RE K
Sbjct: 589 EQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEK 648
Query: 259 RLSLGAQKGRGGERL 273
++ +K R E +
Sbjct: 649 KIREQEEKIREQEEM 663
Score = 46.2 bits (108), Expect = 6e-05
Identities = 56/276 (20%), Positives = 122/276 (44%), Gaps = 34/276 (12%)
Query: 14 DLLAELSEEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGAD 73
+L L+++Q++ ++ +EE+I+ W+E+ E K R ++E + K+
Sbjct: 350 ELWNRLNQQQEEKMW--RQEEKIQEWEEKIQEQEEKI------REQEEKIREQEEKMRRQ 401
Query: 74 KEVWVWVMGEHHLDKPYDVLCNEIIAERARLKAEQEAEEP-----RKTHSEEFTNSLKTK 128
+E+ +W E + + +++ + R + + E EE K H +E + K
Sbjct: 402 EEM-MWEK-EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEK 459
Query: 129 SQYHDL---QAPDNQQTKDIWK---KVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQ 182
Q + Q +Q +W+ K+ E+EE + +EEKI Q+
Sbjct: 460 RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHE--------QE 511
Query: 183 MLADSINRMKAYAFHQKKESMKK-----KQDEEINQIEEERTKQICKSWKEDSEWQASLR 237
+ + R + +++E +++ +Q E+I++ EE+ KQ K W+++ +
Sbjct: 512 KIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEE 571
Query: 238 KSKAADEKRRSLAKQAREDYKRLSLGAQKGRGGERL 273
K + +EK ++ RE +++ +K R E +
Sbjct: 572 KIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEM 607
Score = 44.7 bits (104), Expect = 2e-04
Identities = 44/186 (23%), Positives = 82/186 (44%), Gaps = 22/186 (11%)
Query: 100 ERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPDN--------QQTKDIWK---K 148
ERA+L Q+ + H + S+ K Q Q +N QQ + +W+ K
Sbjct: 313 ERAKLLLPQQQLQAEADHLGKELQSVSAKLQ---AQVEENELWNRLNQQQEEKMWRQEEK 369
Query: 149 VAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRMKAYAFHQKKESMKKKQD 208
+ E EE Q +EEKIR R ++M+ + +M+ ++ K ++
Sbjct: 370 IQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ 429
Query: 209 EEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSLGAQKGR 268
EE+ +EE+ +++ +E Q +R+ E++R ++ RE KR A+ R
Sbjct: 430 EEMMWEKEEKIREL----EEKMHEQEKIRE----QEEKRQEEEKIREQEKRQEQEAKMWR 481
Query: 269 GGERLQ 274
E+++
Sbjct: 482 QEEKIR 487
Score = 41.6 bits (96), Expect = 0.001
Identities = 48/236 (20%), Positives = 102/236 (43%), Gaps = 21/236 (8%)
Query: 40 KEREAAMERKESLPVKPRPKKE-NGKSVHWKLGADKEVWVWVMGEHHLDKPYDVLCNEII 98
KE+ A ++ K L + + + N K + KL K ++ + L D L E+
Sbjct: 281 KEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAK----LLLPQQQLQAEADHLGKELQ 336
Query: 99 AERARLKAEQEAEEP----RKTHSEEFTNSLKTKSQYHDLQAPDNQQTKDIWKKVAEKEE 154
+ A+L+A+ E E + E+ + ++ + ++ ++ +K+ E+EE
Sbjct: 337 SVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEE 396
Query: 155 LEQGSRPAPTLEEEKIR-------SLSSSSRNIQQML---ADSINRMKAYAFHQKK--ES 202
+ +EEK+R R ++M+ + I ++ Q+K E
Sbjct: 397 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ 456
Query: 203 MKKKQDEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYK 258
+K+Q+EE + +E+R +Q K W+++ + + K + +EK ++ E K
Sbjct: 457 EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEK 512
Score = 38.5 bits (88), Expect = 0.013
Identities = 44/218 (20%), Positives = 92/218 (42%), Gaps = 25/218 (11%)
Query: 18 ELSEEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGADKEVW 77
E EQ++I + R+EQ W++ E E++E K + ++ K +E
Sbjct: 505 EKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKI------RKQEEK 558
Query: 78 VWVMGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHS-----EEFTNSLKTK-SQY 131
+W E D+ + E R K ++ E+ R+ EE T + K +
Sbjct: 559 MWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQ 618
Query: 132 HDLQAPDNQQTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRM 191
+ ++ ++ +K+ +EE + +EEKIR ++M+ + +M
Sbjct: 619 EEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ-------EEMMQEQEEKM 671
Query: 192 KAYAFHQKKESMKKKQDEEINQIEEERTKQICKSWKED 229
++E +Q+E++ + EE+ +Q K W+++
Sbjct: 672 ------WEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 703
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 51.6 bits (122), Expect = 1e-06
Identities = 49/180 (27%), Positives = 89/180 (49%), Gaps = 12/180 (6%)
Query: 104 LKAEQEAEEP--RKTHSEEFTNSLKTKSQYHDLQAPDNQQTKDIWKKVAEKEELEQGSRP 161
L+A EAEE +K E+ T K K DL ++Q +K ++ ++ L + S
Sbjct: 980 LEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQ 1039
Query: 162 APTLEEEKIRSLSSSSRNIQQMLADSINRM-KAYAFHQKKESMKKKQDEEINQIEEERTK 220
A EEEK++SL+ + +AD +R+ K Q+ E +K++ D E ++++E+ +
Sbjct: 1040 AAE-EEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVE 1098
Query: 221 QICKS-------WKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSLGAQKGRGGERL 273
Q ++ +++ E QA+L +++ R L K RE L+ AQ+ ER+
Sbjct: 1099 QQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALA-EAQEDLESERV 1157
Score = 33.1 bits (74), Expect = 0.53
Identities = 38/170 (22%), Positives = 76/170 (44%), Gaps = 15/170 (8%)
Query: 98 IAERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPDNQQTKDIWKKVAE----KE 153
+A AR K E E EE + + + Q +QA Q K++W++V E +E
Sbjct: 1639 LAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQA----QMKELWREVEETRTSRE 1694
Query: 154 ELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRMKAYAFHQKKESMKKKQDEEINQ 213
E+ +R + E++++ L + +Q+ LA S +R + A + E + + +++
Sbjct: 1695 EIFSQNRES----EKRLKGLEAEVLRLQEELAAS-DRARRQAQQDRDEMADEVANGNLSK 1749
Query: 214 --IEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLS 261
I EE+ + + + + E + S+ +++ R L Q LS
Sbjct: 1750 AAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELS 1799
Score = 32.0 bits (71), Expect = 1.2
Identities = 41/181 (22%), Positives = 82/181 (45%), Gaps = 23/181 (12%)
Query: 103 RLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPDNQQTKDIWKKVAEKEELEQGSRPA 162
+L AE++A R E + +++ + +A T+ + ++ +EELE+ +R
Sbjct: 1480 QLLAEEKAAVLRAVEERE-----RAEAEGREREARALSLTRALEEEQEAREELERQNRAL 1534
Query: 163 PTLEEEKIRSLSSSSRNIQQMLADSINRMKAYAFHQKKESMKKKQDE----EINQIEEER 218
E + S +++ ++ + R+ A + + + + +DE E ++ E
Sbjct: 1535 RAELEALLSSKDDVGKSVHEL--ERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEV 1592
Query: 219 TKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSLGAQKGRGGERLQSPLR 278
T Q K+ + + + Q + +A +E+RR LAKQ R+ A+ R ER Q L
Sbjct: 1593 TVQALKT-QHERDLQG---RDEAGEERRRQLAKQLRD--------AEVERDEERKQRTLA 1640
Query: 279 V 279
V
Sbjct: 1641 V 1641
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 51.6 bits (122), Expect = 1e-06
Identities = 49/180 (27%), Positives = 89/180 (49%), Gaps = 12/180 (6%)
Query: 104 LKAEQEAEEP--RKTHSEEFTNSLKTKSQYHDLQAPDNQQTKDIWKKVAEKEELEQGSRP 161
L+A EAEE +K E+ T K K DL ++Q +K ++ ++ L + S
Sbjct: 972 LEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQ 1031
Query: 162 APTLEEEKIRSLSSSSRNIQQMLADSINRM-KAYAFHQKKESMKKKQDEEINQIEEERTK 220
A EEEK++SL+ + +AD +R+ K Q+ E +K++ D E ++++E+ +
Sbjct: 1032 AAE-EEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVE 1090
Query: 221 QICKS-------WKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSLGAQKGRGGERL 273
Q ++ +++ E QA+L +++ R L K RE L+ AQ+ ER+
Sbjct: 1091 QQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALA-EAQEDLESERV 1149
Score = 33.1 bits (74), Expect = 0.53
Identities = 38/170 (22%), Positives = 76/170 (44%), Gaps = 15/170 (8%)
Query: 98 IAERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPDNQQTKDIWKKVAE----KE 153
+A AR K E E EE + + + Q +QA Q K++W++V E +E
Sbjct: 1631 LAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQA----QMKELWREVEETRTSRE 1686
Query: 154 ELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRMKAYAFHQKKESMKKKQDEEINQ 213
E+ +R + E++++ L + +Q+ LA S +R + A + E + + +++
Sbjct: 1687 EIFSQNRES----EKRLKGLEAEVLRLQEELAAS-DRARRQAQQDRDEMADEVANGNLSK 1741
Query: 214 --IEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLS 261
I EE+ + + + + E + S+ +++ R L Q LS
Sbjct: 1742 AAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELS 1791
Score = 32.0 bits (71), Expect = 1.2
Identities = 41/181 (22%), Positives = 82/181 (45%), Gaps = 23/181 (12%)
Query: 103 RLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPDNQQTKDIWKKVAEKEELEQGSRPA 162
+L AE++A R E + +++ + +A T+ + ++ +EELE+ +R
Sbjct: 1472 QLLAEEKAAVLRAVEERE-----RAEAEGREREARALSLTRALEEEQEAREELERQNRAL 1526
Query: 163 PTLEEEKIRSLSSSSRNIQQMLADSINRMKAYAFHQKKESMKKKQDE----EINQIEEER 218
E + S +++ ++ + R+ A + + + + +DE E ++ E
Sbjct: 1527 RAELEALLSSKDDVGKSVHEL--ERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEV 1584
Query: 219 TKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSLGAQKGRGGERLQSPLR 278
T Q K+ + + + Q + +A +E+RR LAKQ R+ A+ R ER Q L
Sbjct: 1585 TVQALKT-QHERDLQG---RDEAGEERRRQLAKQLRD--------AEVERDEERKQRTLA 1632
Query: 279 V 279
V
Sbjct: 1633 V 1633
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 51.6 bits (122), Expect = 1e-06
Identities = 49/180 (27%), Positives = 89/180 (49%), Gaps = 12/180 (6%)
Query: 104 LKAEQEAEEP--RKTHSEEFTNSLKTKSQYHDLQAPDNQQTKDIWKKVAEKEELEQGSRP 161
L+A EAEE +K E+ T K K DL ++Q +K ++ ++ L + S
Sbjct: 1013 LEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQ 1072
Query: 162 APTLEEEKIRSLSSSSRNIQQMLADSINRM-KAYAFHQKKESMKKKQDEEINQIEEERTK 220
A EEEK++SL+ + +AD +R+ K Q+ E +K++ D E ++++E+ +
Sbjct: 1073 AAE-EEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVE 1131
Query: 221 QICKS-------WKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSLGAQKGRGGERL 273
Q ++ +++ E QA+L +++ R L K RE L+ AQ+ ER+
Sbjct: 1132 QQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALA-EAQEDLESERV 1190
Score = 33.1 bits (74), Expect = 0.53
Identities = 38/170 (22%), Positives = 76/170 (44%), Gaps = 15/170 (8%)
Query: 98 IAERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPDNQQTKDIWKKVAE----KE 153
+A AR K E E EE + + + Q +QA Q K++W++V E +E
Sbjct: 1672 LAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQA----QMKELWREVEETRTSRE 1727
Query: 154 ELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRMKAYAFHQKKESMKKKQDEEINQ 213
E+ +R + E++++ L + +Q+ LA S +R + A + E + + +++
Sbjct: 1728 EIFSQNRES----EKRLKGLEAEVLRLQEELAAS-DRARRQAQQDRDEMADEVANGNLSK 1782
Query: 214 --IEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLS 261
I EE+ + + + + E + S+ +++ R L Q LS
Sbjct: 1783 AAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELS 1832
Score = 32.0 bits (71), Expect = 1.2
Identities = 41/181 (22%), Positives = 82/181 (45%), Gaps = 23/181 (12%)
Query: 103 RLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPDNQQTKDIWKKVAEKEELEQGSRPA 162
+L AE++A R E + +++ + +A T+ + ++ +EELE+ +R
Sbjct: 1513 QLLAEEKAAVLRAVEERE-----RAEAEGREREARALSLTRALEEEQEAREELERQNRAL 1567
Query: 163 PTLEEEKIRSLSSSSRNIQQMLADSINRMKAYAFHQKKESMKKKQDE----EINQIEEER 218
E + S +++ ++ + R+ A + + + + +DE E ++ E
Sbjct: 1568 RAELEALLSSKDDVGKSVHEL--ERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEV 1625
Query: 219 TKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSLGAQKGRGGERLQSPLR 278
T Q K+ + + + Q + +A +E+RR LAKQ R+ A+ R ER Q L
Sbjct: 1626 TVQALKT-QHERDLQG---RDEAGEERRRQLAKQLRD--------AEVERDEERKQRTLA 1673
Query: 279 V 279
V
Sbjct: 1674 V 1674
>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
Length = 1047
Score = 51.6 bits (122), Expect = 1e-06
Identities = 52/166 (31%), Positives = 73/166 (43%), Gaps = 23/166 (13%)
Query: 286 PPLPPKPQFLNSGAYPQKPLRNQGVVRTLSSSAQEDIIRWFKEE-QLPLRAGYQKTSDTI 344
PPLPP P GA + T+ D + +EE +PL T+
Sbjct: 135 PPLPPPPYLPPLGAG----------LGTVDEGDSLDGPEYEEEEVAIPL------TAPPT 178
Query: 345 APWFHGILTLKKANELLLSTGMPGSFLIRVSERIKG-YALSYLSE-DGCKHFLIDASADA 402
W+HG L A E L G GS+LIR S+R G + LS+LS+ + HF I A
Sbjct: 179 NQWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGD 238
Query: 403 YSFLGVDQLQHATLADLVEYHKEEPITSLGKELLLYPCGQQDQLPD 448
Y G + ++L+DL+ Y+ G E LLYP + + D
Sbjct: 239 YYIGG---RRFSSLSDLIGYYSHVSCLLKG-EKLLYPVAPPEPVED 280
Score = 43.1 bits (100), Expect = 5e-04
Identities = 27/100 (27%), Positives = 53/100 (53%), Gaps = 5/100 (5%)
Query: 347 WFHGILTLKKANELLLSTGMPGSFLIRVSERIKG-YALSYLSEDGCKHFLIDASADAYSF 405
WFHG ++ ++A LL++ G SFL+R S+ G Y+L + + + + F I + +
Sbjct: 351 WFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFM 410
Query: 406 LGVDQLQHATLADLVEYHKEEPITSLGKELLLYPCGQQDQ 445
+G + ++ D+++++++E I L P QDQ
Sbjct: 411 MG--GRYYNSIGDIIDHYRKEQIVE--GYYLKEPVPMQDQ 446
>gi|33356177 protein tyrosine phosphatase, non-receptor type 11
[Homo sapiens]
Length = 593
Score = 50.1 bits (118), Expect = 4e-06
Identities = 31/80 (38%), Positives = 43/80 (53%), Gaps = 3/80 (3%)
Query: 347 WFHGILTLKKANELLLSTGMPGSFLIRVSERIKG-YALSYLSEDGCKHFLIDASADAYSF 405
WFH +T +A LLL+ G+ GSFL R S+ G + LS H I + D Y
Sbjct: 6 WFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDL 65
Query: 406 LGVDQLQHATLADLVEYHKE 425
G ++ ATLA+LV+Y+ E
Sbjct: 66 YGGEKF--ATLAELVQYYME 83
Score = 45.1 bits (105), Expect = 1e-04
Identities = 37/103 (35%), Positives = 52/103 (50%), Gaps = 14/103 (13%)
Query: 347 WFHGILTLKKANELLLSTGMPGSFLIRVSERIKG-YALSYL-------SEDG---CKHFL 395
WFHG L+ K+A +LL G GSFL+R S+ G + LS S DG H +
Sbjct: 112 WFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVM 171
Query: 396 IDASADAYSFLGVDQLQHATLADLVEYHKEEP-ITSLGKELLL 437
I Y G ++ +L DLVE++K+ P + +LG L L
Sbjct: 172 IRCQELKYDVGGGERFD--SLTDLVEHYKKNPMVETLGTVLQL 212
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 49.7 bits (117), Expect = 6e-06
Identities = 48/244 (19%), Positives = 100/244 (40%), Gaps = 15/244 (6%)
Query: 30 KMREEQIRRW------KEREAAMERKESLPVKPRPKKENGKSVHWKLGADKEVWVWVMGE 83
KMR ++ W +E E M +E + + ++E K + ++E +W E
Sbjct: 331 KMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE 390
Query: 84 HHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPDNQQTK 143
++ E I E+ + EQE E E+ + + + ++ +
Sbjct: 391 KIREQ------EEKIREQEEMMQEQE--EKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIR 442
Query: 144 DIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRMKAYAFHQKKESM 203
+ KK+ E+EE + +EEK+ + + + +M+ +++
Sbjct: 443 EQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEK 502
Query: 204 K-KKQDEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSL 262
K ++Q+E+I + EE +Q K W+++ + K + +EK R ++ RE RL
Sbjct: 503 KIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQ 562
Query: 263 GAQK 266
+K
Sbjct: 563 QEEK 566
Score = 47.0 bits (110), Expect = 4e-05
Identities = 55/253 (21%), Positives = 113/253 (44%), Gaps = 26/253 (10%)
Query: 18 ELSEEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGA---DK 74
+L E +K + ++E ++R ER + ++ L + + +SV KL A +
Sbjct: 219 QLVESEKSEIQLNVKE--LKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEEN 276
Query: 75 EVWVWVMGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDL 134
E+W + + +K + E I ER E++ +E + E+ + + +
Sbjct: 277 ELWNR-LNQQQEEKMWRQ--EEKIQER-----EEKIQEQEEKIREQEEKMRRQEEMMWEK 328
Query: 135 QAPDNQQTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRMKAY 194
+ +Q + +W+K + ELE+ E+EKIR R ++ + + R +
Sbjct: 329 EEKMRRQEEMMWEKEEKIRELEEKMH-----EQEKIRE-QEEKRQEEEKIREQEKRQEQE 382
Query: 195 AFHQKKESMKKKQDEEI-------NQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRR 247
A ++E ++Q+E+I + EE+ +Q K W+++ E Q K + +EK R
Sbjct: 383 AKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIR 442
Query: 248 SLAKQAREDYKRL 260
K+ RE +++
Sbjct: 443 EQEKKIREQEEKI 455
Score = 45.4 bits (106), Expect = 1e-04
Identities = 50/267 (18%), Positives = 114/267 (42%), Gaps = 18/267 (6%)
Query: 11 IDPDLLAELSEEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKL 70
+ L A++ E + + +EE++ W++ E ER+E + + +E + +
Sbjct: 265 VSAKLQAQVEENELWNRLNQQQEEKM--WRQEEKIQEREEKIQEQEEKIREQEEKMR--- 319
Query: 71 GADKEVWVWVMGEHHLDKPYDVLCN--EIIAERARLKAEQEA--EEPRKTHSEEFTNSLK 126
+E +W E + + +++ E I E EQE E+ K EE +
Sbjct: 320 --RQEEMMWEK-EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQE 376
Query: 127 TKSQYHDLQAPDNQQTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLAD 186
+ + ++ ++ +K+ E+EE+ Q +EEK+ + ++ +
Sbjct: 377 KRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRR 436
Query: 187 SINRMKAYAFHQKKESMKKKQDEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKR 246
+++ ++E ++Q+E+I + EE +Q K +++ + K + +EK
Sbjct: 437 QEEKIR------EQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKM 490
Query: 247 RSLAKQAREDYKRLSLGAQKGRGGERL 273
R ++ RE K++ +K R E +
Sbjct: 491 RRQEEKIREQEKKIREQEEKIREQEEM 517
Score = 42.0 bits (97), Expect = 0.001
Identities = 42/235 (17%), Positives = 107/235 (45%), Gaps = 33/235 (14%)
Query: 21 EEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGADKEVWVWV 80
EE+K K +E++ + W++ E E++E + R ++E + K+G +E +W
Sbjct: 368 EEEKIREQEKRQEQEAKMWRQEEKIREQEEKI----REQEEMMQEQEEKMGEQEEK-MWE 422
Query: 81 MGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPDNQ 140
E ++ E+ R + E+ E+ +K +E K + Q +Q + +
Sbjct: 423 QEEEMQEQE----------EKMRRQEEKIREQEKKIREQEE----KIREQEEMMQEQEEK 468
Query: 141 QTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRMKAYAFHQKK 200
+ K ++ ++++ +EEK+R R ++ + + +++ ++
Sbjct: 469 MGEQEGKMCEQEAKMQE--------QEEKMRRQEEKIREQEKKIREQEEKIR------EQ 514
Query: 201 ESMKKKQDEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQARE 255
E M ++Q+E++ + EE+ +Q K +++ + + K + + + R ++ +E
Sbjct: 515 EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 49.7 bits (117), Expect = 6e-06
Identities = 56/274 (20%), Positives = 118/274 (43%), Gaps = 30/274 (10%)
Query: 21 EEQKQILFFKMREE-QIRRWKEREAAMERKESLPVK-PRPKKENGKSVHWK--------- 69
+++K+ + KM E Q ++ +R+ ++KE L + R +N + + K
Sbjct: 674 QQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQ 733
Query: 70 -LGADKEVWVWVMGEHHLDKPYDVLCNEI-----IAERARLKAEQEAEEPRKTHSEEFTN 123
L D+E +W M EH L + + ++ ++ + L+ ++ E + +++
Sbjct: 734 ELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIE 793
Query: 124 SLKTKSQYHDLQAPDNQQTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLS-------SS 176
LK + Q + P Q+++ + K+ L + + EKI+ S S
Sbjct: 794 QLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKS 853
Query: 177 SRNIQQMLADSINRMKAYAFHQKKESMKKKQDEEINQIEEERTKQICKSWKED-----SE 231
R QQ ++ R +++ Q+E+ + + E T+++ K+ E E
Sbjct: 854 ERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHETQKL-KALDESHNQNLKE 912
Query: 232 WQASLRKSKAADEKRRSLAKQAREDYKRLSLGAQ 265
W+ LR K A E+ + K+ +E + +LS A+
Sbjct: 913 WRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAE 946
Score = 35.8 bits (81), Expect = 0.082
Identities = 36/151 (23%), Positives = 65/151 (43%), Gaps = 9/151 (5%)
Query: 105 KAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPDNQQTKDIWKKVAEKEELEQGSRPAPT 164
K E + E+ K +E + K K +L+ + QQ + + K E++ + A
Sbjct: 586 KHELQLEQMHKRFEQEI--NAKKKFFDTELENLERQQKQQVEKM--EQDHAVRRREEARR 641
Query: 165 LEEEKIRSLSSSSRNIQQMLADSINRMKAYAFHQKKESMKKKQDEEINQIEEERTKQICK 224
+ E+ R + ++ M + N ++ Q+KESMK+K EE Q ++ +
Sbjct: 642 IRLEQDRDYTRFQEQLKLMKKEVKNEVEKLPRQQRKESMKQKM-EEHTQKKQLLDRDFVA 700
Query: 225 SWKEDSEWQASLRKSKAADEKRRSLAKQARE 255
KED E L + + RR + + RE
Sbjct: 701 KQKEDLE----LAMKRLTTDNRREICDKERE 727
>gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]
Length = 2817
Score = 49.7 bits (117), Expect = 6e-06
Identities = 47/191 (24%), Positives = 89/191 (46%), Gaps = 31/191 (16%)
Query: 159 SRPAPTLEEEKIRSLSSSSRNI-------QQMLADSINRMKAYAFHQK----KESMKKKQ 207
SRP+ +E+EK RSL +++ Q L + R + + ++ +E++ ++
Sbjct: 2567 SRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQR 2626
Query: 208 DEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSLGAQKG 267
+EE+ Q +++ K+ + ++ +Q L + +AA ++ +Q R + +RLS Q
Sbjct: 2627 EEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLS-QRQTE 2685
Query: 268 RGGERLQSP----LRVPQ---KPERPPLPPKPQFLNSGAYPQK----PLRN--------Q 308
R ++ P +R+P PE PP P P SG+ + P RN +
Sbjct: 2686 RDLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSIAKSGSLDSELSVSPKRNSISRTHKDK 2745
Query: 309 GVVRTLSSSAQ 319
G LSS++Q
Sbjct: 2746 GPFHILSSTSQ 2756
>gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]
Length = 1058
Score = 49.7 bits (117), Expect = 6e-06
Identities = 47/191 (24%), Positives = 89/191 (46%), Gaps = 31/191 (16%)
Query: 159 SRPAPTLEEEKIRSLSSSSRNI-------QQMLADSINRMKAYAFHQK----KESMKKKQ 207
SRP+ +E+EK RSL +++ Q L + R + + ++ +E++ ++
Sbjct: 808 SRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQR 867
Query: 208 DEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSLGAQKG 267
+EE+ Q +++ K+ + ++ +Q L + +AA ++ +Q R + +RLS Q
Sbjct: 868 EEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLS-QRQTE 926
Query: 268 RGGERLQSP----LRVPQ---KPERPPLPPKPQFLNSGAYPQK----PLRN--------Q 308
R ++ P +R+P PE PP P P SG+ + P RN +
Sbjct: 927 RDLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSIAKSGSLDSELSVSPKRNSISRTHKDK 986
Query: 309 GVVRTLSSSAQ 319
G LSS++Q
Sbjct: 987 GPFHILSSTSQ 997
>gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]
Length = 2813
Score = 49.7 bits (117), Expect = 6e-06
Identities = 47/191 (24%), Positives = 89/191 (46%), Gaps = 31/191 (16%)
Query: 159 SRPAPTLEEEKIRSLSSSSRNI-------QQMLADSINRMKAYAFHQK----KESMKKKQ 207
SRP+ +E+EK RSL +++ Q L + R + + ++ +E++ ++
Sbjct: 2563 SRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQR 2622
Query: 208 DEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSLGAQKG 267
+EE+ Q +++ K+ + ++ +Q L + +AA ++ +Q R + +RLS Q
Sbjct: 2623 EEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLS-QRQTE 2681
Query: 268 RGGERLQSP----LRVPQ---KPERPPLPPKPQFLNSGAYPQK----PLRN--------Q 308
R ++ P +R+P PE PP P P SG+ + P RN +
Sbjct: 2682 RDLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSIAKSGSLDSELSVSPKRNSISRTHKDK 2741
Query: 309 GVVRTLSSSAQ 319
G LSS++Q
Sbjct: 2742 GPFHILSSTSQ 2752
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 48.5 bits (114), Expect = 1e-05
Identities = 34/107 (31%), Positives = 54/107 (50%), Gaps = 4/107 (3%)
Query: 346 PWFHGILTLKKANELLLSTGMPGSFLIRVSERIKG-YALSYLSEDGCKHFLIDASADAYS 404
PWF G + KA E+L G+FLIR SE G ++LS + +HF +
Sbjct: 59 PWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKY 118
Query: 405 FLGVDQLQHATLADLVEYHKEEPITSLGKELLLYPCGQQDQLPDYLE 451
FL V ++ +L +LV+YH+ + S +++ L Q Q P Y++
Sbjct: 119 FLWV--VKFNSLNELVDYHRSTSV-SRNQQIFLRDIEQVPQQPTYVQ 162
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 48.5 bits (114), Expect = 1e-05
Identities = 32/114 (28%), Positives = 52/114 (45%), Gaps = 11/114 (9%)
Query: 347 WFHGILTLKKANELLLSTGMPGSFLIRVSERIKGYALSYLSEDGCKHFLIDASADAYSFL 406
W+H LT +A +L+ G+FL+R YA+S+ +E KH + L
Sbjct: 668 WYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTV-ML 726
Query: 407 GVDQLQHATLADLVEYHKEEPITSLGKELLLYPCGQQ------DQLPDYLELFE 454
G + +L DL+ Y+++ P+ K L YP ++ PDY L+E
Sbjct: 727 GNSEFD--SLVDLISYYEKHPL--YRKMKLRYPINEEALEKIGTAEPDYGALYE 776
>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
Length = 1290
Score = 48.5 bits (114), Expect = 1e-05
Identities = 32/114 (28%), Positives = 52/114 (45%), Gaps = 11/114 (9%)
Query: 347 WFHGILTLKKANELLLSTGMPGSFLIRVSERIKGYALSYLSEDGCKHFLIDASADAYSFL 406
W+H LT +A +L+ G+FL+R YA+S+ +E KH + L
Sbjct: 668 WYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTV-ML 726
Query: 407 GVDQLQHATLADLVEYHKEEPITSLGKELLLYPCGQQ------DQLPDYLELFE 454
G + +L DL+ Y+++ P+ K L YP ++ PDY L+E
Sbjct: 727 GNSEFD--SLVDLISYYEKHPL--YRKMKLRYPINEEALEKIGTAEPDYGALYE 776
>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
Length = 870
Score = 48.5 bits (114), Expect = 1e-05
Identities = 37/104 (35%), Positives = 52/104 (50%), Gaps = 6/104 (5%)
Query: 347 WFHGILTLKKANELLLSTGMPGSFLIRVSERIKG-YALSYLSE-DGCKHFLIDASADAYS 404
W+HG L A E L G GS+LIR S+R G + LS+LS+ + HF I A Y
Sbjct: 4 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY 63
Query: 405 FLGVDQLQHATLADLVEYHKEEPITSLGKELLLYPCGQQDQLPD 448
G + ++L+DL+ Y+ G E LLYP + + D
Sbjct: 64 IGG---RRFSSLSDLIGYYSHVSCLLKG-EKLLYPVAPPEPVED 103
Score = 43.1 bits (100), Expect = 5e-04
Identities = 27/100 (27%), Positives = 53/100 (53%), Gaps = 5/100 (5%)
Query: 347 WFHGILTLKKANELLLSTGMPGSFLIRVSERIKG-YALSYLSEDGCKHFLIDASADAYSF 405
WFHG ++ ++A LL++ G SFL+R S+ G Y+L + + + + F I + +
Sbjct: 174 WFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFM 233
Query: 406 LGVDQLQHATLADLVEYHKEEPITSLGKELLLYPCGQQDQ 445
+G + ++ D+++++++E I L P QDQ
Sbjct: 234 MG--GRYYNSIGDIIDHYRKEQIVE--GYYLKEPVPMQDQ 269
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.374
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,522,512
Number of Sequences: 37866
Number of extensions: 912061
Number of successful extensions: 7506
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 110
Number of HSP's successfully gapped in prelim test: 621
Number of HSP's that attempted gapping in prelim test: 5586
Number of HSP's gapped (non-prelim): 1742
length of query: 454
length of database: 18,247,518
effective HSP length: 106
effective length of query: 348
effective length of database: 14,233,722
effective search space: 4953335256
effective search space used: 4953335256
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.